SRPK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.73954926
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.45657224
3CENP-A containing nucleosome assembly (GO:0034080)4.21620876
4mitotic metaphase plate congression (GO:0007080)4.18925567
5chromatin remodeling at centromere (GO:0031055)4.15712704
6ribosome assembly (GO:0042255)4.11373319
7kinetochore organization (GO:0051383)4.09628598
8DNA topological change (GO:0006265)4.05460722
9DNA replication checkpoint (GO:0000076)4.01166379
10DNA replication initiation (GO:0006270)3.98025916
11ribosomal small subunit assembly (GO:0000028)3.95677234
12telomere maintenance via semi-conservative replication (GO:0032201)3.95659157
13regulation of translational fidelity (GO:0006450)3.93771009
14DNA strand elongation involved in DNA replication (GO:0006271)3.92777882
15non-recombinational repair (GO:0000726)3.86962833
16double-strand break repair via nonhomologous end joining (GO:0006303)3.86962833
17proteasome assembly (GO:0043248)3.84615029
18nuclear pore complex assembly (GO:0051292)3.83711271
19formation of translation preinitiation complex (GO:0001731)3.81940457
20DNA strand elongation (GO:0022616)3.80427329
21telomere maintenance via recombination (GO:0000722)3.77683238
22kinetochore assembly (GO:0051382)3.72311859
23metaphase plate congression (GO:0051310)3.72208082
24meiotic chromosome segregation (GO:0045132)3.72111826
25nuclear pore organization (GO:0006999)3.71334532
26regulation of chromosome segregation (GO:0051983)3.70034386
27positive regulation of chromosome segregation (GO:0051984)3.66443918
28nucleobase biosynthetic process (GO:0046112)3.62212415
29mitotic recombination (GO:0006312)3.61876697
30DNA replication-independent nucleosome assembly (GO:0006336)3.61585664
31DNA replication-independent nucleosome organization (GO:0034724)3.61585664
32purine nucleobase biosynthetic process (GO:0009113)3.59785535
33histone exchange (GO:0043486)3.57609771
34DNA duplex unwinding (GO:0032508)3.57200055
35protein K6-linked ubiquitination (GO:0085020)3.56488928
36chromosome condensation (GO:0030261)3.54601801
37heterochromatin organization (GO:0070828)3.54491412
38regulation of mitotic spindle organization (GO:0060236)3.54290794
39establishment of chromosome localization (GO:0051303)3.52346284
40maturation of 5.8S rRNA (GO:0000460)3.51615717
41protein localization to kinetochore (GO:0034501)3.49609453
42IMP biosynthetic process (GO:0006188)3.49277088
43regulation of sister chromatid cohesion (GO:0007063)3.49240837
44DNA geometric change (GO:0032392)3.46740566
45establishment of viral latency (GO:0019043)3.44676558
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.44116624
47regulation of centriole replication (GO:0046599)3.41696503
48mitotic spindle assembly checkpoint (GO:0007094)3.40453225
49* chromosome segregation (GO:0007059)3.39696587
50maturation of SSU-rRNA (GO:0030490)3.38689561
51regulation of DNA endoreduplication (GO:0032875)3.35332372
52telomere maintenance via telomere lengthening (GO:0010833)3.30778540
53DNA ligation (GO:0006266)3.28529867
54attachment of spindle microtubules to kinetochore (GO:0008608)3.27588258
55folic acid-containing compound biosynthetic process (GO:0009396)3.27427734
56mitotic nuclear envelope disassembly (GO:0007077)3.27037929
57* DNA conformation change (GO:0071103)3.26839638
58microtubule depolymerization (GO:0007019)3.23721984
59mitotic sister chromatid segregation (GO:0000070)3.23090480
60nuclear envelope organization (GO:0006998)3.21605560
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.20002870
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19154660
63regulation of mitotic spindle checkpoint (GO:1903504)3.19154660
64regulation of centrosome cycle (GO:0046605)3.18136865
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.17928101
66DNA deamination (GO:0045006)3.17540888
67chromatin assembly or disassembly (GO:0006333)3.17086612
68cellular protein complex localization (GO:0034629)3.16473820
69protein localization to chromosome, centromeric region (GO:0071459)3.16248501
70protein complex localization (GO:0031503)3.14973549
71protein localization to chromosome (GO:0034502)3.14206186
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13906725
73mitotic G2/M transition checkpoint (GO:0044818)3.11669688
74pore complex assembly (GO:0046931)3.11545896
75* DNA packaging (GO:0006323)3.10521666
76regulation of RNA export from nucleus (GO:0046831)3.09981136
77spindle checkpoint (GO:0031577)3.09676611
78pre-miRNA processing (GO:0031054)3.08600796
79ribosome biogenesis (GO:0042254)3.04830110
80regulation of nuclear cell cycle DNA replication (GO:0033262)3.04141969
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.02873553
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.02873553
83positive regulation of mitotic sister chromatid separation (GO:1901970)3.02873553
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.02553994
85RNA-dependent DNA replication (GO:0006278)3.02364842
86DNA replication-dependent nucleosome organization (GO:0034723)3.01708952
87DNA replication-dependent nucleosome assembly (GO:0006335)3.01708952
88rRNA modification (GO:0000154)3.00176326
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99687553
90DNA synthesis involved in DNA repair (GO:0000731)2.98596448
91transcription elongation from RNA polymerase I promoter (GO:0006362)2.98278578
92transcription-coupled nucleotide-excision repair (GO:0006283)2.97430491
93membrane disassembly (GO:0030397)2.97292091
94nuclear envelope disassembly (GO:0051081)2.97292091
95tRNA aminoacylation for protein translation (GO:0006418)2.96637577
96termination of RNA polymerase I transcription (GO:0006363)2.96395942
97DNA double-strand break processing (GO:0000729)2.96277763
98mismatch repair (GO:0006298)2.95932971
99viral mRNA export from host cell nucleus (GO:0046784)2.95927019
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95506168
101positive regulation of cell cycle checkpoint (GO:1901978)2.94851032
102ribosomal large subunit biogenesis (GO:0042273)2.92273556
103IMP metabolic process (GO:0046040)2.90793340
104mitotic sister chromatid cohesion (GO:0007064)2.90572053
105negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89954133
106negative regulation of sister chromatid segregation (GO:0033046)2.89954133
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.89954133
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89954133
109histone H2A acetylation (GO:0043968)2.89090210
110regulation of spindle organization (GO:0090224)2.89051772
111mitotic spindle checkpoint (GO:0071174)2.88772758
112telomere maintenance (GO:0000723)2.88757700
113DNA catabolic process, exonucleolytic (GO:0000738)2.88509065
114ribonucleoprotein complex biogenesis (GO:0022613)2.88271539
115negative regulation of chromosome segregation (GO:0051985)2.87546968
1167-methylguanosine mRNA capping (GO:0006370)2.87483781
117transcription from RNA polymerase I promoter (GO:0006360)2.87402965
1187-methylguanosine RNA capping (GO:0009452)2.86722642
119RNA capping (GO:0036260)2.86722642
120regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86531404
121telomere organization (GO:0032200)2.85822445
122DNA-dependent DNA replication (GO:0006261)2.85674829
123mitotic chromosome condensation (GO:0007076)2.84684099
124DNA replication (GO:0006260)2.84439177
125ATP-dependent chromatin remodeling (GO:0043044)2.83921865
126intra-S DNA damage checkpoint (GO:0031573)2.83745375
127negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83682132
128sister chromatid segregation (GO:0000819)2.82339267
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81762646
130spliceosomal snRNP assembly (GO:0000387)2.80604131
131transcription initiation from RNA polymerase I promoter (GO:0006361)2.80263241
132replication fork processing (GO:0031297)2.79272094
133spindle assembly checkpoint (GO:0071173)2.79184905
134sister chromatid cohesion (GO:0007062)2.78641451
135pseudouridine synthesis (GO:0001522)2.77901918
136DNA unwinding involved in DNA replication (GO:0006268)2.77548962
137somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77446328
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.77446328
139inner cell mass cell proliferation (GO:0001833)2.77435228
140regulation of mitotic sister chromatid separation (GO:0010965)2.77350708
141regulation of mitotic sister chromatid segregation (GO:0033047)2.77350708
142regulation of sister chromatid segregation (GO:0033045)2.77350708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.96534101
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.23630054
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.64536879
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62475595
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.59065054
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.46013803
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.21299168
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76562971
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.66987179
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.64882062
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57158852
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54662132
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45871986
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43372491
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42656670
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41100823
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.39054039
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.38163638
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.33918854
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.28028020
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26836129
22VDR_23849224_ChIP-Seq_CD4+_Human2.22863959
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20097989
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19444548
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.16396011
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14204225
27E2F1_21310950_ChIP-Seq_MCF-7_Human2.11248929
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.08847200
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07368050
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06735384
31FOXP3_21729870_ChIP-Seq_TREG_Human2.04131736
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01688039
33* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95261267
34ELK1_19687146_ChIP-ChIP_HELA_Human1.93505147
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87227054
36* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.84074071
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79853899
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76227226
39AR_21909140_ChIP-Seq_LNCAP_Human1.75481201
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.73681844
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73264017
42* XRN2_22483619_ChIP-Seq_HELA_Human1.72751835
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69310234
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66530550
45TTF2_22483619_ChIP-Seq_HELA_Human1.65969845
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65941203
47DCP1A_22483619_ChIP-Seq_HELA_Human1.64234775
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63491912
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60144556
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.58793663
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51153560
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.50736259
53* GABP_19822575_ChIP-Seq_HepG2_Human1.47986436
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.47029835
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44291912
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.39345623
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35589012
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32729632
59MYC_18940864_ChIP-ChIP_HL60_Human1.32354650
60CIITA_25753668_ChIP-Seq_RAJI_Human1.32213058
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29691126
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28372563
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27830323
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26888002
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23865315
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18046888
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17318599
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17243040
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15412515
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13129475
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12068057
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10694179
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.10017881
74KDM5A_27292631_Chip-Seq_BREAST_Human1.10003266
75IRF1_19129219_ChIP-ChIP_H3396_Human1.09892804
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08448993
77CHD1_26751641_Chip-Seq_LNCaP_Human1.06473754
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01083738
79* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01046714
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99864036
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99545467
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99481053
83EGR1_19374776_ChIP-ChIP_THP-1_Human0.97547715
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97430207
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93746553
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91999206
87* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90080895
88EWS_26573619_Chip-Seq_HEK293_Human0.89998450
89STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87600823
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86605278
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86308718
92SPI1_23547873_ChIP-Seq_NB4_Human0.84400226
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83232072
94* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81710138
95* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81651697
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.81017841
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81014448
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.80775509
99ZNF263_19887448_ChIP-Seq_K562_Human0.80128665
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79673955
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77756225
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77243529
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.75506726
104SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74395006
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73969264
106FUS_26573619_Chip-Seq_HEK293_Human0.73212332
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.73185623
108* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71566222
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.69241384
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.69141634
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68625011
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65857955
113STAT4_19710469_ChIP-ChIP_TH1__Mouse0.64966552
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.64385968
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.64281997
116TFEB_21752829_ChIP-Seq_HELA_Human0.63350400
117MYC_22102868_ChIP-Seq_BL_Human0.63248807
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.63204722
119* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.62943997
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.62039589

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.23169232
2MP0003693_abnormal_embryo_hatching4.18353838
3MP0008057_abnormal_DNA_replication4.02767778
4MP0008058_abnormal_DNA_repair3.60296170
5MP0003111_abnormal_nucleus_morphology3.55612257
6MP0008877_abnormal_DNA_methylation3.31028017
7MP0003077_abnormal_cell_cycle3.29533461
8MP0004957_abnormal_blastocyst_morpholog3.09616815
9MP0006292_abnormal_olfactory_placode3.00915946
10MP0008007_abnormal_cellular_replicative2.82189174
11MP0002396_abnormal_hematopoietic_system2.65029228
12MP0010352_gastrointestinal_tract_polyps2.50683196
13MP0003786_premature_aging2.20090836
14MP0008932_abnormal_embryonic_tissue2.17394600
15MP0001188_hyperpigmentation2.15689090
16MP0000566_synostosis2.06274307
17MP0002877_abnormal_melanocyte_morpholog1.87308522
18MP0003123_paternal_imprinting1.83948264
19MP0003763_abnormal_thymus_physiology1.80727151
20MP0003718_maternal_effect1.73642695
21MP0005075_abnormal_melanosome_morpholog1.70492017
22MP0003315_abnormal_perineum_morphology1.70129136
23MP0000015_abnormal_ear_pigmentation1.69711886
24MP0005409_darkened_coat_color1.65475750
25MP0010234_abnormal_vibrissa_follicle1.64188513
26MP0004808_abnormal_hematopoietic_stem1.64042958
27MP0000350_abnormal_cell_proliferation1.61100471
28MP0003136_yellow_coat_color1.60066760
29MP0002210_abnormal_sex_determination1.59700509
30MP0000490_abnormal_crypts_of1.55928154
31MP0004381_abnormal_hair_follicle1.52101558
32MP0003121_genomic_imprinting1.51749916
33MP0003941_abnormal_skin_development1.48987535
34MP0009697_abnormal_copulation1.45734287
35MP0001929_abnormal_gametogenesis1.41500308
36MP0001730_embryonic_growth_arrest1.39588366
37MP0003787_abnormal_imprinting1.39326731
38MP0003221_abnormal_cardiomyocyte_apopto1.38017235
39MP0005076_abnormal_cell_differentiation1.37863562
40MP0005174_abnormal_tail_pigmentation1.37815110
41MP0002095_abnormal_skin_pigmentation1.36683607
42MP0002160_abnormal_reproductive_system1.34563308
43MP0005408_hypopigmentation1.34247661
44MP0000537_abnormal_urethra_morphology1.31796679
45MP0001145_abnormal_male_reproductive1.25565128
46MP0010307_abnormal_tumor_latency1.25257014
47MP0009333_abnormal_splenocyte_physiolog1.24295858
48MP0001119_abnormal_female_reproductive1.22924010
49MP0002009_preneoplasia1.20528075
50MP0009379_abnormal_foot_pigmentation1.19143358
51MP0004185_abnormal_adipocyte_glucose1.18765341
52MP0001672_abnormal_embryogenesis/_devel1.18226656
53MP0005380_embryogenesis_phenotype1.18226656
54MP0000653_abnormal_sex_gland1.17942187
55MP0006035_abnormal_mitochondrial_morpho1.17526627
56MP0003806_abnormal_nucleotide_metabolis1.17418143
57MP0000372_irregular_coat_pigmentation1.15056340
58MP0000516_abnormal_urinary_system1.14498283
59MP0005367_renal/urinary_system_phenotyp1.14498283
60MP0001697_abnormal_embryo_size1.14145520
61MP0002697_abnormal_eye_size1.12156290
62MP0004233_abnormal_muscle_weight1.10657894
63MP0000313_abnormal_cell_death1.10299541
64MP0004264_abnormal_extraembryonic_tissu1.04828227
65MP0005389_reproductive_system_phenotype1.03828442
66MP0008789_abnormal_olfactory_epithelium1.03017910
67MP0003890_abnormal_embryonic-extraembry1.02895552
68MP0003943_abnormal_hepatobiliary_system1.00715972
69MP0000703_abnormal_thymus_morphology1.00301244
70MP0000358_abnormal_cell_content/1.00019997
71MP0003566_abnormal_cell_adhesion0.99949050
72MP0002102_abnormal_ear_morphology0.99860173
73MP0002085_abnormal_embryonic_tissue0.99580231
74MP0002938_white_spotting0.99279020
75MP0005501_abnormal_skin_physiology0.98409368
76MP0002398_abnormal_bone_marrow0.97906424
77MP0003984_embryonic_growth_retardation0.97870367
78MP0002019_abnormal_tumor_incidence0.97688612
79MP0001293_anophthalmia0.97669065
80MP0003698_abnormal_male_reproductive0.97571252
81MP0002796_impaired_skin_barrier0.95867016
82MP0000428_abnormal_craniofacial_morphol0.94988460
83MP0002088_abnormal_embryonic_growth/wei0.94381404
84MP0003705_abnormal_hypodermis_morpholog0.93935742
85MP0004782_abnormal_surfactant_physiolog0.93290363
86MP0004197_abnormal_fetal_growth/weight/0.92479986
87MP0002080_prenatal_lethality0.92228544
88MP0002111_abnormal_tail_morphology0.91856392
89MP0003385_abnormal_body_wall0.90468910
90MP0001919_abnormal_reproductive_system0.90350234
91MP0002234_abnormal_pharynx_morphology0.90173252
92MP0005451_abnormal_body_composition0.89816574
93MP0005384_cellular_phenotype0.89093774
94MP0002092_abnormal_eye_morphology0.88216449
95MP0003937_abnormal_limbs/digits/tail_de0.87493146
96MP0005671_abnormal_response_to0.86951001
97MP0005621_abnormal_cell_physiology0.86668141
98MP0002132_abnormal_respiratory_system0.85910392
99MP0001545_abnormal_hematopoietic_system0.85653206
100MP0005397_hematopoietic_system_phenotyp0.85653206
101MP0003567_abnormal_fetal_cardiomyocyte0.85267686
102MP0001286_abnormal_eye_development0.84322268
103MP0002233_abnormal_nose_morphology0.84265629
104MP0002084_abnormal_developmental_patter0.84242364
105MP0010030_abnormal_orbit_morphology0.83719095
106MP0000049_abnormal_middle_ear0.82637860
107MP0009053_abnormal_anal_canal0.81899967
108MP0002177_abnormal_outer_ear0.81744923
109MP0002277_abnormal_respiratory_mucosa0.81342511
110MP0009672_abnormal_birth_weight0.80302776
111MP0002751_abnormal_autonomic_nervous0.79950734
112MP0005171_absent_coat_pigmentation0.79764248
113MP0001186_pigmentation_phenotype0.79148372
114MP0008995_early_reproductive_senescence0.78618173
115MP0002722_abnormal_immune_system0.78584594
116MP0000689_abnormal_spleen_morphology0.78062232
117MP0002086_abnormal_extraembryonic_tissu0.76701753
118MP0001915_intracranial_hemorrhage0.76532619
119MP0005394_taste/olfaction_phenotype0.76378141
120MP0005499_abnormal_olfactory_system0.76378141
121MP0003950_abnormal_plasma_membrane0.76375111
122MP0003115_abnormal_respiratory_system0.75282270
123MP0003938_abnormal_ear_development0.74571860
124MP0005410_abnormal_fertilization0.73924981
125MP0003119_abnormal_digestive_system0.71621386
126MP0003936_abnormal_reproductive_system0.70833429
127MP0000647_abnormal_sebaceous_gland0.70800006
128MP0002006_tumorigenesis0.70417248
129MP0003699_abnormal_female_reproductive0.68827663
130MP0002075_abnormal_coat/hair_pigmentati0.68311684
131MP0002060_abnormal_skin_morphology0.68292843
132MP0000432_abnormal_head_morphology0.68056703
133MP0003861_abnormal_nervous_system0.67234238
134MP0002163_abnormal_gland_morphology0.67025206
135MP0001216_abnormal_epidermal_layer0.67000920
136MP0003935_abnormal_craniofacial_develop0.66785395
137MP0009703_decreased_birth_body0.66448172
138MP0002429_abnormal_blood_cell0.66057535
139MP0005395_other_phenotype0.65618476
140MP0000716_abnormal_immune_system0.65239042
141MP0001661_extended_life_span0.64829209
142MP0000762_abnormal_tongue_morphology0.58292299
143MP0010678_abnormal_skin_adnexa0.58008683
144MP0003755_abnormal_palate_morphology0.57333211
145MP0000579_abnormal_nail_morphology0.57268451
146MP0001346_abnormal_lacrimal_gland0.56942452

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.90461371
2Birth length less than 3rd percentile (HP:0003561)4.70946397
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.67177379
4Increased nuchal translucency (HP:0010880)3.37352953
5Meckel diverticulum (HP:0002245)3.34707189
6Abnormality of the preputium (HP:0100587)3.25192884
7Abnormality of chromosome stability (HP:0003220)3.23061256
8Abnormality of the ileum (HP:0001549)3.17815223
9Ectopic kidney (HP:0000086)3.13776628
10Abnormal lung lobation (HP:0002101)3.09416790
11Breast hypoplasia (HP:0003187)3.07397581
12Patellar aplasia (HP:0006443)3.07154234
1311 pairs of ribs (HP:0000878)3.01643387
14Aplasia/Hypoplasia of the uvula (HP:0010293)2.93098136
15Reticulocytopenia (HP:0001896)2.91311218
16Aplasia/Hypoplasia of the patella (HP:0006498)2.90770974
17Impulsivity (HP:0100710)2.87464417
18Nephroblastoma (Wilms tumor) (HP:0002667)2.86061002
19Abnormality of glycolysis (HP:0004366)2.83300004
20Myelodysplasia (HP:0002863)2.80152086
21Deviation of the thumb (HP:0009603)2.73739517
22Cortical dysplasia (HP:0002539)2.68654922
23Proximal placement of thumb (HP:0009623)2.68557330
24Degeneration of anterior horn cells (HP:0002398)2.67230718
25Abnormality of the anterior horn cell (HP:0006802)2.67230718
26Embryonal renal neoplasm (HP:0011794)2.66978520
27Supernumerary spleens (HP:0009799)2.66489762
28Increased serum pyruvate (HP:0003542)2.63033909
29Aplastic anemia (HP:0001915)2.62813613
30Duodenal stenosis (HP:0100867)2.51763380
31Small intestinal stenosis (HP:0012848)2.51763380
32Carpal bone hypoplasia (HP:0001498)2.51249251
33Multiple enchondromatosis (HP:0005701)2.47696803
34Cafe-au-lait spot (HP:0000957)2.35324855
35Clubbing of toes (HP:0100760)2.35162364
36Absent thumb (HP:0009777)2.34962851
37Type I transferrin isoform profile (HP:0003642)2.34847255
38Short middle phalanx of the 5th finger (HP:0004220)2.34704617
39Abnormality of methionine metabolism (HP:0010901)2.30818390
40Absent radius (HP:0003974)2.30299901
41Abnormality of the fingertips (HP:0001211)2.29453443
42Bone marrow hypocellularity (HP:0005528)2.28755059
43Rhabdomyosarcoma (HP:0002859)2.28596470
44Acute myeloid leukemia (HP:0004808)2.27409401
45Ankyloglossia (HP:0010296)2.24101998
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23890641
47Overlapping toe (HP:0001845)2.22369098
48Abnormality of the duodenum (HP:0002246)2.21888538
49Embryonal neoplasm (HP:0002898)2.21122246
50Sloping forehead (HP:0000340)2.18875470
51Medulloblastoma (HP:0002885)2.18839747
52Triphalangeal thumb (HP:0001199)2.17464864
53Abnormal number of erythroid precursors (HP:0012131)2.17101626
54Aplasia involving forearm bones (HP:0009822)2.15120673
55Absent forearm bone (HP:0003953)2.15120673
56Type 2 muscle fiber atrophy (HP:0003554)2.14517176
57Missing ribs (HP:0000921)2.13846890
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.13070310
59Abnormal foot bone ossification (HP:0010675)2.12658458
60Short thumb (HP:0009778)2.10082534
61Colon cancer (HP:0003003)2.09291148
62Choanal atresia (HP:0000453)2.07521659
63Progressive external ophthalmoplegia (HP:0000590)2.06923024
64Abnormality of the renal collecting system (HP:0004742)2.06424231
65Premature graying of hair (HP:0002216)2.05360779
66Intestinal fistula (HP:0100819)2.04300051
67Horseshoe kidney (HP:0000085)2.03301040
68Duplicated collecting system (HP:0000081)2.03057963
69Abnormality of the labia minora (HP:0012880)2.02648486
70Neoplasm of the colon (HP:0100273)2.01801386
71True hermaphroditism (HP:0010459)2.01322275
72Abnormality of cells of the erythroid lineage (HP:0012130)2.00871731
73Selective tooth agenesis (HP:0001592)2.00393684
74Insidious onset (HP:0003587)2.00022381
75Termporal pattern (HP:0011008)2.00022381
76Oral leukoplakia (HP:0002745)1.99294736
77Lip pit (HP:0100267)1.96227696
78Optic nerve coloboma (HP:0000588)1.95794735
79Abnormality of cochlea (HP:0000375)1.94264300
80Progressive muscle weakness (HP:0003323)1.93684901
81Volvulus (HP:0002580)1.93533766
82Microglossia (HP:0000171)1.93509854
83Abnormality of the carotid arteries (HP:0005344)1.93094819
84Cholecystitis (HP:0001082)1.92235197
85Abnormal gallbladder physiology (HP:0012438)1.92235197
86Abnormality of DNA repair (HP:0003254)1.91399698
87Cleft eyelid (HP:0000625)1.90351008
88High anterior hairline (HP:0009890)1.89296474
89Gastrointestinal carcinoma (HP:0002672)1.88745489
90Malignant gastrointestinal tract tumors (HP:0006749)1.88745489
91Facial cleft (HP:0002006)1.88516624
92Macrocytic anemia (HP:0001972)1.87982392
93Abnormal spermatogenesis (HP:0008669)1.87436996
94Pancreatic fibrosis (HP:0100732)1.85895343
95Septate vagina (HP:0001153)1.85689543
96Sandal gap (HP:0001852)1.85653913
97Pancreatic islet-cell hyperplasia (HP:0004510)1.84514342
98Hypoplasia of the radius (HP:0002984)1.82074547
99Muscle fiber atrophy (HP:0100295)1.79507704
100Leiomyosarcoma (HP:0100243)1.79416253
101Uterine leiomyosarcoma (HP:0002891)1.79416253
102Premature ovarian failure (HP:0008209)1.78501533
103Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.78388779
104Preaxial hand polydactyly (HP:0001177)1.77779394
105Atresia of the external auditory canal (HP:0000413)1.73866763
106Anal stenosis (HP:0002025)1.73826105
107Rough bone trabeculation (HP:0100670)1.73653442
108Orthostatic hypotension (HP:0001278)1.72436729
109Spastic diplegia (HP:0001264)1.72417890
110Abnormal umbilical cord blood vessels (HP:0011403)1.71873307
111Single umbilical artery (HP:0001195)1.71873307
112Abnormality of the fetal cardiovascular system (HP:0010948)1.71873307
113Ependymoma (HP:0002888)1.71661650
114Microvesicular hepatic steatosis (HP:0001414)1.71250713
115Arteriovenous malformation (HP:0100026)1.71172201
116Lymphoma (HP:0002665)1.70965434
117Thrombocytosis (HP:0001894)1.70426937
118Pulmonary fibrosis (HP:0002206)1.70222725
119Uterine neoplasm (HP:0010784)1.69878671
120Pallor (HP:0000980)1.69678320
121Papillary thyroid carcinoma (HP:0002895)1.68648633
122Poikiloderma (HP:0001029)1.68595492
123Rectovaginal fistula (HP:0000143)1.68409466
124Rectal fistula (HP:0100590)1.68409466
125Pancreatic cysts (HP:0001737)1.68222279
126Abnormal protein glycosylation (HP:0012346)1.67665625
127Abnormal glycosylation (HP:0012345)1.67665625
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67665625
129Abnormal protein N-linked glycosylation (HP:0012347)1.67665625
130Abnormal number of incisors (HP:0011064)1.66484843
131Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65800130
132Diastasis recti (HP:0001540)1.65709948
133IgM deficiency (HP:0002850)1.65334194
134Median cleft lip (HP:0000161)1.64901380
135Neuroblastoma (HP:0003006)1.64757737
136Primitive neuroectodermal tumor (HP:0030065)1.64757737
137Neuroblastic tumors (HP:0004376)1.64757737
138Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.64757737
139Tracheoesophageal fistula (HP:0002575)1.64678067
140Abnormality of the columella (HP:0009929)1.63279225
141Capillary hemangiomas (HP:0005306)1.61928299
142Secondary amenorrhea (HP:0000869)1.61751567
143Biliary tract neoplasm (HP:0100574)1.61430061
144Pancytopenia (HP:0001876)1.61273701
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61255020
146Neoplasm of the small intestine (HP:0100833)1.61021676
147Cellular immunodeficiency (HP:0005374)1.61005762
148Severe visual impairment (HP:0001141)1.60983784
149Microretrognathia (HP:0000308)1.60908801
150Squamous cell carcinoma (HP:0002860)1.60165452
151Adrenal hypoplasia (HP:0000835)1.59851002
152Megaloblastic anemia (HP:0001889)1.59495677
153Absent/shortened dynein arms (HP:0200106)1.59444053
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.59444053
155Ovarian neoplasm (HP:0100615)1.58489015
156Hypoplastic pelvis (HP:0008839)1.58217020
157Abnormality of homocysteine metabolism (HP:0010919)1.58051732
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.57515179
159Intestinal atresia (HP:0011100)1.56034546
160Deep philtrum (HP:0002002)1.55201947
161Supernumerary bones of the axial skeleton (HP:0009144)1.53394766
162Agnosia (HP:0010524)1.53359502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.76088744
2BUB13.25304391
3PBK3.19661205
4WEE13.06355483
5MKNK12.93740722
6PLK42.87582616
7MKNK22.86684712
8EIF2AK12.76790252
9TSSK62.31477013
10* SRPK12.30696922
11CASK2.29003816
12MUSK2.20711059
13BRSK22.13440180
14VRK12.09472107
15AKT32.07380014
16ZAK2.05839926
17TXK2.02706722
18PLK31.89924927
19TTK1.83849922
20EIF2AK21.79217013
21PLK11.74340185
22EIF2AK31.74255439
23ATR1.67921800
24STK161.65692001
25TLK11.64856299
26NEK21.63136426
27STK38L1.62437696
28SCYL21.55660264
29ACVR1B1.54283563
30VRK21.53640239
31MST1R1.49589474
32TAF11.47583733
33CDK71.43453337
34CHEK21.42531701
35SMG11.41095388
36CCNB11.37235073
37TRIM281.36361272
38CLK11.35507335
39EEF2K1.34941146
40AURKB1.31278974
41LATS11.26667730
42ICK1.23645771
43PASK1.23022996
44MAP3K101.21843872
45NEK61.21191211
46PNCK1.21168926
47BRSK11.15713279
48IRAK41.13894097
49MAP3K81.09574884
50CDK81.09022479
51CHEK11.06238911
52MET1.05940771
53ATM1.05393995
54NME21.04121576
55PIM11.03129171
56STK41.02345600
57BRD41.01678408
58PAK41.00871603
59ALK0.99514761
60TEC0.98929492
61IRAK30.96716587
62BMPR20.95893093
63STK240.95001592
64MAP3K140.92458831
65NUAK10.91280386
66SGK20.87345621
67ERBB40.87095809
68AURKA0.85678457
69BCR0.83396943
70BRAF0.80982835
71TGFBR10.80843731
72CDK60.80235735
73YES10.79644465
74ERBB30.78631152
75EPHA20.77948886
76MST40.73877064
77CDK20.73287572
78BMPR1B0.73225682
79RPS6KB20.70948821
80CDK120.70445897
81MAP4K10.68095047
82RAF10.67397865
83STK100.66949916
84* CSNK2A10.66142642
85LATS20.64542502
86NEK90.64224927
87NME10.64061820
88CDK10.62899706
89FGFR10.60992007
90CDK40.59028724
91* CSNK2A20.59005564
92CSNK1E0.58983303
93KSR10.58978723
94STK30.58755999
95PLK20.57873032
96CDK30.57482193
97CHUK0.56545053
98MELK0.55018360
99STK390.53344367
100SIK30.52515567
101NEK10.51494368
102MAP3K20.50703186
103RPS6KA40.49905994
104RPS6KB10.48715570
105BTK0.48633275
106SGK30.48202164
107CDK90.46200723
108IKBKB0.46075039
109GRK10.44029837
110PDK20.43906693
111NLK0.42887845
112DYRK30.42376036
113IKBKE0.41731204
114PRKDC0.40894364
115JAK30.39649683
116TESK10.39472085
117MAPK130.37992874
118KSR20.37748193
119MTOR0.36079606
120PIM20.36003107
121RPS6KA60.35325754
122TRPM70.34931086
123RPS6KA50.34910482
124PRPF4B0.33939297
125PRKCI0.33079598
126CDK180.32540663
127MAP2K60.32319081
128MAPK140.32260304
129CAMK1G0.32195318
130MAP3K60.31076696
131WNK10.30818446
132MAP2K30.30587948
133KIT0.30518650
134MINK10.30278504
135RPS6KL10.29828928
136RPS6KC10.29828928
137CSNK1A1L0.29188379
138CDK140.27670264
139CDK150.27409539
140TNIK0.26603729
141CDK11A0.26493036

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.34759536
2Mismatch repair_Homo sapiens_hsa034303.85230893
3Homologous recombination_Homo sapiens_hsa034403.56644702
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50648025
5RNA polymerase_Homo sapiens_hsa030203.32716395
6Base excision repair_Homo sapiens_hsa034103.07377476
7Fanconi anemia pathway_Homo sapiens_hsa034603.03149794
8Spliceosome_Homo sapiens_hsa030402.99609053
9RNA transport_Homo sapiens_hsa030132.77581350
10Cell cycle_Homo sapiens_hsa041102.75611434
11Nucleotide excision repair_Homo sapiens_hsa034202.72983952
12Basal transcription factors_Homo sapiens_hsa030222.63227979
13Non-homologous end-joining_Homo sapiens_hsa034502.58403389
14Proteasome_Homo sapiens_hsa030502.52360853
15Ribosome_Homo sapiens_hsa030102.49854006
16RNA degradation_Homo sapiens_hsa030182.36131600
17Pyrimidine metabolism_Homo sapiens_hsa002402.27523338
18One carbon pool by folate_Homo sapiens_hsa006702.19605056
19mRNA surveillance pathway_Homo sapiens_hsa030151.84009286
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79187288
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66501015
22Biosynthesis of amino acids_Homo sapiens_hsa012301.54913829
23p53 signaling pathway_Homo sapiens_hsa041151.54233644
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53485512
25Purine metabolism_Homo sapiens_hsa002301.49480854
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23704581
27Epstein-Barr virus infection_Homo sapiens_hsa051691.18672499
28Pyruvate metabolism_Homo sapiens_hsa006201.17487578
29Carbon metabolism_Homo sapiens_hsa012001.12471770
30Protein export_Homo sapiens_hsa030601.10653461
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08357356
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05343809
33* Herpes simplex infection_Homo sapiens_hsa051681.04409361
34Primary immunodeficiency_Homo sapiens_hsa053400.97490961
35Oocyte meiosis_Homo sapiens_hsa041140.93747207
36Steroid biosynthesis_Homo sapiens_hsa001000.93395067
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93194624
38Measles_Homo sapiens_hsa051620.90968142
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89634324
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89398241
41Pentose phosphate pathway_Homo sapiens_hsa000300.87069178
42Thyroid cancer_Homo sapiens_hsa052160.86144284
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83941817
44Lysine degradation_Homo sapiens_hsa003100.81549501
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80975055
46Arachidonic acid metabolism_Homo sapiens_hsa005900.80427049
47Folate biosynthesis_Homo sapiens_hsa007900.80318897
48Adherens junction_Homo sapiens_hsa045200.78930712
49Antigen processing and presentation_Homo sapiens_hsa046120.78744179
50Systemic lupus erythematosus_Homo sapiens_hsa053220.76569133
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.76535480
52Vitamin B6 metabolism_Homo sapiens_hsa007500.76299979
53Chronic myeloid leukemia_Homo sapiens_hsa052200.75589504
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.74916841
55Propanoate metabolism_Homo sapiens_hsa006400.74318057
56Viral carcinogenesis_Homo sapiens_hsa052030.72906290
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72396825
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71861360
59HTLV-I infection_Homo sapiens_hsa051660.71531903
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70009198
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68256940
62Pancreatic cancer_Homo sapiens_hsa052120.68067799
63MicroRNAs in cancer_Homo sapiens_hsa052060.67966888
64Allograft rejection_Homo sapiens_hsa053300.67449138
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64058018
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.58888001
67Non-small cell lung cancer_Homo sapiens_hsa052230.58853203
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56126747
69Autoimmune thyroid disease_Homo sapiens_hsa053200.55811846
70Hematopoietic cell lineage_Homo sapiens_hsa046400.55368654
71Huntingtons disease_Homo sapiens_hsa050160.54679353
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51310662
73Influenza A_Homo sapiens_hsa051640.50603665
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.49572827
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49291703
76N-Glycan biosynthesis_Homo sapiens_hsa005100.49066600
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48852608
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48257868
79Phototransduction_Homo sapiens_hsa047440.46666482
80Fatty acid elongation_Homo sapiens_hsa000620.46471296
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46241225
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44540220
83Small cell lung cancer_Homo sapiens_hsa052220.43348643
84Arginine biosynthesis_Homo sapiens_hsa002200.42347578
85Graft-versus-host disease_Homo sapiens_hsa053320.41139062
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40952831
87Bladder cancer_Homo sapiens_hsa052190.40416666
88Sulfur relay system_Homo sapiens_hsa041220.39773193
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.39703108
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39011695
91Basal cell carcinoma_Homo sapiens_hsa052170.38004509
92Prostate cancer_Homo sapiens_hsa052150.37829384
93TGF-beta signaling pathway_Homo sapiens_hsa043500.37775409
94Glutathione metabolism_Homo sapiens_hsa004800.37166041
95Galactose metabolism_Homo sapiens_hsa000520.37057949
96Endometrial cancer_Homo sapiens_hsa052130.36936189
97Legionellosis_Homo sapiens_hsa051340.36425753
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.35875490
99Asthma_Homo sapiens_hsa053100.35670096
100Fructose and mannose metabolism_Homo sapiens_hsa000510.35077004
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34713636
102Hepatitis B_Homo sapiens_hsa051610.34437817
103Sphingolipid metabolism_Homo sapiens_hsa006000.34274094
104T cell receptor signaling pathway_Homo sapiens_hsa046600.32246509
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31763003
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31038150
107Wnt signaling pathway_Homo sapiens_hsa043100.30464647
108Acute myeloid leukemia_Homo sapiens_hsa052210.30240832
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30054595
110Renal cell carcinoma_Homo sapiens_hsa052110.29190879
111Linoleic acid metabolism_Homo sapiens_hsa005910.28919978
112Fatty acid metabolism_Homo sapiens_hsa012120.26889331
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26427354
114HIF-1 signaling pathway_Homo sapiens_hsa040660.25405494
115Pathways in cancer_Homo sapiens_hsa052000.24562380
116Fatty acid biosynthesis_Homo sapiens_hsa000610.24066195
117Apoptosis_Homo sapiens_hsa042100.22824229
118Colorectal cancer_Homo sapiens_hsa052100.22637453
119Ether lipid metabolism_Homo sapiens_hsa005650.22586569
120Proteoglycans in cancer_Homo sapiens_hsa052050.22467200
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22362632
122Alcoholism_Homo sapiens_hsa050340.22052715
123Melanoma_Homo sapiens_hsa052180.21724264
124Glioma_Homo sapiens_hsa052140.21462015
125Parkinsons disease_Homo sapiens_hsa050120.20871623
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.19940815
127Notch signaling pathway_Homo sapiens_hsa043300.19766860
128ErbB signaling pathway_Homo sapiens_hsa040120.19063431
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18892608
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18718371
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17922985
132Hippo signaling pathway_Homo sapiens_hsa043900.16892361
133Selenocompound metabolism_Homo sapiens_hsa004500.15583062
134FoxO signaling pathway_Homo sapiens_hsa040680.15078702
135Circadian rhythm_Homo sapiens_hsa047100.14516446
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14474387
137Leishmaniasis_Homo sapiens_hsa051400.14281695
138Metabolic pathways_Homo sapiens_hsa011000.13815636
139Shigellosis_Homo sapiens_hsa051310.12493915
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.10727958
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10643413

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