SRPK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.18361390
2presynaptic membrane assembly (GO:0097105)4.90623067
3presynaptic membrane organization (GO:0097090)4.72274754
4synaptic vesicle exocytosis (GO:0016079)4.70078617
5neuron cell-cell adhesion (GO:0007158)4.69978385
6vocalization behavior (GO:0071625)4.68782661
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.67470801
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60641143
9regulation of synaptic vesicle exocytosis (GO:2000300)4.50180887
10glutamate secretion (GO:0014047)4.42999963
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40095214
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.35352970
13protein localization to synapse (GO:0035418)4.33753955
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.23778848
15regulation of glutamate receptor signaling pathway (GO:1900449)4.17119673
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.16064667
17neurotransmitter-gated ion channel clustering (GO:0072578)4.15020094
18neuronal action potential propagation (GO:0019227)4.13421423
19regulation of synaptic vesicle transport (GO:1902803)4.10938583
20synaptic vesicle maturation (GO:0016188)4.03491167
21locomotory exploration behavior (GO:0035641)3.95816184
22postsynaptic membrane organization (GO:0001941)3.91982231
23glutamate receptor signaling pathway (GO:0007215)3.90082610
24synaptic transmission, glutamatergic (GO:0035249)3.88791099
25neuron-neuron synaptic transmission (GO:0007270)3.84146783
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76723182
27regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.76123683
28pyrimidine nucleobase catabolic process (GO:0006208)3.75598735
29neurotransmitter secretion (GO:0007269)3.70740957
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.63978202
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57245460
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.54983592
33regulation of neuronal synaptic plasticity (GO:0048168)3.54709160
34cellular potassium ion homeostasis (GO:0030007)3.53647806
35sodium ion export (GO:0071436)3.47219344
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45296650
37startle response (GO:0001964)3.43038740
38synaptic vesicle endocytosis (GO:0048488)3.42739083
39neuron recognition (GO:0008038)3.42198627
40regulation of postsynaptic membrane potential (GO:0060078)3.36256545
41establishment of mitochondrion localization (GO:0051654)3.35452618
42detection of calcium ion (GO:0005513)3.34377283
43cerebellar Purkinje cell differentiation (GO:0021702)3.33674222
44long-term memory (GO:0007616)3.33648295
45long-term synaptic potentiation (GO:0060291)3.30273267
46exploration behavior (GO:0035640)3.29876598
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.22838353
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22582357
49regulation of neurotransmitter secretion (GO:0046928)3.21729116
50auditory behavior (GO:0031223)3.20124338
51positive regulation of membrane potential (GO:0045838)3.18446221
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16541131
53axonal fasciculation (GO:0007413)3.15989666
54gamma-aminobutyric acid transport (GO:0015812)3.15064926
55neuronal ion channel clustering (GO:0045161)3.14986806
56mechanosensory behavior (GO:0007638)3.14437439
57regulation of dendritic spine development (GO:0060998)3.10876093
58positive regulation of synapse maturation (GO:0090129)3.10840612
59regulation of vesicle fusion (GO:0031338)3.10349929
60positive regulation of synapse assembly (GO:0051965)3.08765353
61dendritic spine morphogenesis (GO:0060997)3.08153558
62central nervous system myelination (GO:0022010)3.07240455
63axon ensheathment in central nervous system (GO:0032291)3.07240455
64central nervous system projection neuron axonogenesis (GO:0021952)3.07112229
65neurotransmitter transport (GO:0006836)3.06808883
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05694557
67regulation of synaptic transmission, GABAergic (GO:0032228)3.05076753
68regulation of synapse structural plasticity (GO:0051823)3.04676108
69calcium ion-dependent exocytosis (GO:0017156)3.03743631
70synapse assembly (GO:0007416)3.03371548
71regulation of synaptic plasticity (GO:0048167)3.02411918
72nucleobase catabolic process (GO:0046113)3.01347643
73positive regulation of dendritic spine morphogenesis (GO:0061003)3.00713738
74membrane depolarization during action potential (GO:0086010)2.99570821
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99471760
76regulation of neurotransmitter transport (GO:0051588)2.98611861
77cerebellar granule cell differentiation (GO:0021707)2.98452808
78transmission of nerve impulse (GO:0019226)2.98371424
79protein targeting to Golgi (GO:0000042)2.97689116
80establishment of protein localization to Golgi (GO:0072600)2.96706654
81membrane depolarization (GO:0051899)2.94736607
82vesicle transport along microtubule (GO:0047496)2.93921099
83acrosome reaction (GO:0007340)2.92924106
84negative regulation of dendrite development (GO:2000171)2.92015467
85organelle transport along microtubule (GO:0072384)2.88984019
86layer formation in cerebral cortex (GO:0021819)2.88371617
87regulation of respiratory system process (GO:0044065)2.87092339
88regulation of synapse assembly (GO:0051963)2.86361429
89proline transport (GO:0015824)2.86181759
90negative regulation of dendrite morphogenesis (GO:0050774)2.85844530
91regulation of synapse maturation (GO:0090128)2.85360624
92regulation of dendritic spine morphogenesis (GO:0061001)2.83705816
93innervation (GO:0060384)2.83415307
94behavioral response to cocaine (GO:0048148)2.83334626
95positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82734525
96adult walking behavior (GO:0007628)2.82559935
97positive regulation of neurotransmitter secretion (GO:0001956)2.81817104
98positive regulation of neurotransmitter transport (GO:0051590)2.81634126
99learning (GO:0007612)2.80822557
100striatum development (GO:0021756)2.79693834
101retrograde transport, vesicle recycling within Golgi (GO:0000301)2.79577638
102L-amino acid import (GO:0043092)2.78902790
103cerebral cortex radially oriented cell migration (GO:0021799)2.78733383
104dendritic spine organization (GO:0097061)2.77986011
105establishment of vesicle localization (GO:0051650)2.77691503
106response to auditory stimulus (GO:0010996)2.77530413
107positive regulation of synaptic transmission (GO:0050806)2.77240990
108behavioral fear response (GO:0001662)2.76460443
109behavioral defense response (GO:0002209)2.76460443
110membrane hyperpolarization (GO:0060081)2.76301296
111glycosphingolipid biosynthetic process (GO:0006688)2.75767209
112C4-dicarboxylate transport (GO:0015740)2.74219787
113fear response (GO:0042596)2.73822839
114righting reflex (GO:0060013)2.73135939
115synaptic transmission (GO:0007268)2.71981389
116regulation of neurotransmitter levels (GO:0001505)2.71951184
117regulation of neurotransmitter uptake (GO:0051580)2.70917819
118potassium ion import (GO:0010107)2.70678479
119regulation of synaptic transmission (GO:0050804)2.68855504
120dendrite morphogenesis (GO:0048813)2.68746174
121mitochondrion transport along microtubule (GO:0047497)2.68132966
122establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.68132966
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68097205
124central nervous system neuron axonogenesis (GO:0021955)2.67747851
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67596635
126neurofilament cytoskeleton organization (GO:0060052)2.66456992
127regulation of respiratory gaseous exchange (GO:0043576)2.63652993
128establishment of synaptic vesicle localization (GO:0097480)2.63389479
129synaptic vesicle transport (GO:0048489)2.63389479
130response to histamine (GO:0034776)2.62931587
131negative regulation of neurotransmitter transport (GO:0051589)2.62414935
132dendrite development (GO:0016358)2.59612739

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.71913722
2* GBX2_23144817_ChIP-Seq_PC3_Human3.89510054
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59226228
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55812010
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.52058418
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50207170
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.49604984
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45428080
9TAF15_26573619_Chip-Seq_HEK293_Human2.37428518
10REST_21632747_ChIP-Seq_MESCs_Mouse2.24255839
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23748463
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.23746002
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17705328
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13510137
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13510137
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12980908
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06469284
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06206851
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04458474
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03893389
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98003132
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96854788
23* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95963198
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.94465399
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94181534
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.90733451
27SMAD4_21799915_ChIP-Seq_A2780_Human1.89370785
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87909098
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.86576020
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.82388715
31DROSHA_22980978_ChIP-Seq_HELA_Human1.80598058
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78812017
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78563791
34* P300_19829295_ChIP-Seq_ESCs_Human1.77420499
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.76658842
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76546864
37FUS_26573619_Chip-Seq_HEK293_Human1.72523318
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70231427
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69863260
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.69444741
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.67325377
42* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66770591
43AR_21572438_ChIP-Seq_LNCaP_Human1.64907645
44RNF2_27304074_Chip-Seq_NSC_Mouse1.64218542
45IGF1R_20145208_ChIP-Seq_DFB_Human1.61344591
46VDR_22108803_ChIP-Seq_LS180_Human1.53287556
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52082171
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52021570
49* PIAS1_25552417_ChIP-Seq_VCAP_Human1.50521336
50STAT3_23295773_ChIP-Seq_U87_Human1.49335135
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45624648
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43878413
53* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42900935
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42888595
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40880239
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38411092
57CBP_20019798_ChIP-Seq_JUKART_Human1.38411092
58* AR_25329375_ChIP-Seq_VCAP_Human1.37452086
59TCF4_23295773_ChIP-Seq_U87_Human1.36569974
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35630511
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.35520626
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35018605
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32901987
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29878365
65* ER_23166858_ChIP-Seq_MCF-7_Human1.27336094
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27278963
67* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26488839
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.26482619
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26353494
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26353494
71* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23957524
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23300014
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20803748
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.19807225
75SOX9_26525672_Chip-Seq_HEART_Mouse1.19202717
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18918189
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18506261
78* RUNX2_22187159_ChIP-Seq_PCA_Human1.18290085
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.18266547
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17343832
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17110908
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15382702
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15222959
84E2F1_18555785_Chip-Seq_ESCs_Mouse1.14859775
85ZNF274_21170338_ChIP-Seq_K562_Hela1.14844196
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14443819
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14187557
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14115062
89* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12953476
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11293407
91P53_22387025_ChIP-Seq_ESCs_Mouse1.10805467
92* AR_19668381_ChIP-Seq_PC3_Human1.10668308
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10545992
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09576850
95* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08659823
96* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08550600
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08308207
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.08031251
99* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07917846
100EWS_26573619_Chip-Seq_HEK293_Human1.07766967
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.07268937
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06896564
103KDM2B_26808549_Chip-Seq_REH_Human1.06694091
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.06437880
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06387815
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05741063
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04348592
108* AHR_22903824_ChIP-Seq_MCF-7_Human1.03846524
109BCAT_22108803_ChIP-Seq_LS180_Human1.03536485
110JUN_21703547_ChIP-Seq_K562_Human1.01070280
111SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00751222
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.99535739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.80216732
2MP0003880_abnormal_central_pattern4.48514269
3MP0003635_abnormal_synaptic_transmissio3.59108204
4MP0004270_analgesia3.06738746
5MP0009745_abnormal_behavioral_response3.03038941
6MP0009046_muscle_twitch2.91592838
7MP0002063_abnormal_learning/memory/cond2.87796292
8MP0002064_seizures2.72888349
9MP0003787_abnormal_imprinting2.64352793
10MP0001968_abnormal_touch/_nociception2.58394748
11MP0002572_abnormal_emotion/affect_behav2.57815137
12MP0005423_abnormal_somatic_nervous2.46912297
13MP0001486_abnormal_startle_reflex2.44218951
14MP0002272_abnormal_nervous_system2.40945839
15MP0001188_hyperpigmentation2.39590931
16MP0002734_abnormal_mechanical_nocicepti2.38637613
17MP0005646_abnormal_pituitary_gland2.26946977
18MP0002736_abnormal_nociception_after2.03351077
19MP0001984_abnormal_olfaction1.99201117
20MP0002822_catalepsy1.98319957
21MP0002735_abnormal_chemical_nociception1.97567045
22MP0002067_abnormal_sensory_capabilities1.95149774
23MP0000778_abnormal_nervous_system1.94528308
24MP0001501_abnormal_sleep_pattern1.83372447
25MP0005645_abnormal_hypothalamus_physiol1.80998755
26MP0001440_abnormal_grooming_behavior1.78754087
27MP0006276_abnormal_autonomic_nervous1.75727013
28MP0009780_abnormal_chondrocyte_physiolo1.75631118
29MP0002184_abnormal_innervation1.75325740
30MP0002557_abnormal_social/conspecific_i1.72618264
31MP0010386_abnormal_urinary_bladder1.72084741
32MP0001970_abnormal_pain_threshold1.69757383
33MP0002733_abnormal_thermal_nociception1.69446903
34MP0003122_maternal_imprinting1.68340759
35MP0008569_lethality_at_weaning1.64452480
36MP0001529_abnormal_vocalization1.64243298
37MP0004924_abnormal_behavior1.60242340
38MP0005386_behavior/neurological_phenoty1.60242340
39MP0008877_abnormal_DNA_methylation1.51943876
40MP0003879_abnormal_hair_cell1.47022504
41MP0001502_abnormal_circadian_rhythm1.45681993
42MP0006292_abnormal_olfactory_placode1.43315139
43MP0004811_abnormal_neuron_physiology1.41450033
44MP0000955_abnormal_spinal_cord1.37472404
45MP0005551_abnormal_eye_electrophysiolog1.37263363
46MP0002882_abnormal_neuron_morphology1.36951431
47MP0000569_abnormal_digit_pigmentation1.33343884
48MP0002638_abnormal_pupillary_reflex1.30866769
49MP0005410_abnormal_fertilization1.28826656
50MP0005171_absent_coat_pigmentation1.28484746
51MP0004742_abnormal_vestibular_system1.27632834
52MP0006072_abnormal_retinal_apoptosis1.23952696
53MP0005174_abnormal_tail_pigmentation1.23315181
54MP0002909_abnormal_adrenal_gland1.23284009
55MP0001905_abnormal_dopamine_level1.22211386
56MP0002066_abnormal_motor_capabilities/c1.22114185
57MP0000631_abnormal_neuroendocrine_gland1.21896274
58MP0005187_abnormal_penis_morphology1.17898111
59MP0004885_abnormal_endolymph1.17056746
60MP0003121_genomic_imprinting1.16750766
61MP0004142_abnormal_muscle_tone1.12197569
62MP0002152_abnormal_brain_morphology1.08475673
63MP0005499_abnormal_olfactory_system1.04684491
64MP0005394_taste/olfaction_phenotype1.04684491
65MP0000013_abnormal_adipose_tissue1.01585194
66MP0004145_abnormal_muscle_electrophysio1.00951504
67MP0005409_darkened_coat_color0.99773018
68MP0000015_abnormal_ear_pigmentation0.99349291
69MP0003890_abnormal_embryonic-extraembry0.99302150
70MP0003633_abnormal_nervous_system0.97757888
71MP0001963_abnormal_hearing_physiology0.95925064
72MP0000920_abnormal_myelination0.94885138
73MP0002837_dystrophic_cardiac_calcinosis0.92376813
74MP0002095_abnormal_skin_pigmentation0.90828181
75MP0002752_abnormal_somatic_nervous0.89776933
76MP0003690_abnormal_glial_cell0.89491222
77MP0000427_abnormal_hair_cycle0.89383194
78MP0003698_abnormal_male_reproductive0.88676448
79MP0002229_neurodegeneration0.88066054
80MP0002102_abnormal_ear_morphology0.87801675
81MP0003631_nervous_system_phenotype0.86599103
82MP0001177_atelectasis0.86114310
83MP0002876_abnormal_thyroid_physiology0.84784564
84MP0005253_abnormal_eye_physiology0.83023988
85MP0003183_abnormal_peptide_metabolism0.82996239
86MP0001986_abnormal_taste_sensitivity0.82449522
87MP0005075_abnormal_melanosome_morpholog0.82441344
88MP0004085_abnormal_heartbeat0.82052539
89MP0005248_abnormal_Harderian_gland0.81936230
90MP0001485_abnormal_pinna_reflex0.81314721
91MP0001929_abnormal_gametogenesis0.78641407
92MP0000751_myopathy0.77282508
93MP0002069_abnormal_eating/drinking_beha0.76712692
94MP0004043_abnormal_pH_regulation0.75161653
95MP0000026_abnormal_inner_ear0.73399246
96MP0004215_abnormal_myocardial_fiber0.73138607
97MP0004858_abnormal_nervous_system0.70642591
98MP0005379_endocrine/exocrine_gland_phen0.68487846
99MP0002751_abnormal_autonomic_nervous0.67493715
100MP0003861_abnormal_nervous_system0.66712035
101MP0004381_abnormal_hair_follicle0.66386450
102MP0003329_amyloid_beta_deposits0.66068163
103MP0003632_abnormal_nervous_system0.62190212
104MP0003634_abnormal_glial_cell0.60879749
105MP0003123_paternal_imprinting0.58919056
106MP0002234_abnormal_pharynx_morphology0.58824221
107MP0002653_abnormal_ependyma_morphology0.58735886
108MP0001664_abnormal_digestion0.57931357
109MP0010770_preweaning_lethality0.57212502
110MP0002082_postnatal_lethality0.57212502
111MP0000372_irregular_coat_pigmentation0.56931979
112MP0005195_abnormal_posterior_eye0.56573035
113MP0010769_abnormal_survival0.56122894
114MP0004484_altered_response_of0.55586494
115MP0008789_abnormal_olfactory_epithelium0.55268030
116MP0001324_abnormal_eye_pigmentation0.54856911
117MP0010768_mortality/aging0.54733517
118MP0001943_abnormal_respiration0.54626402
119MP0008995_early_reproductive_senescence0.54614509

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.22682365
2Febrile seizures (HP:0002373)4.89441319
3Epileptic encephalopathy (HP:0200134)4.81654236
4Focal seizures (HP:0007359)4.69949457
5Atonic seizures (HP:0010819)4.56680009
6Progressive cerebellar ataxia (HP:0002073)4.13907054
7Myokymia (HP:0002411)3.97672307
8Visual hallucinations (HP:0002367)3.92228205
9Hyperventilation (HP:0002883)3.60049296
10Absence seizures (HP:0002121)3.52227697
11Broad-based gait (HP:0002136)3.51311013
12Gaze-evoked nystagmus (HP:0000640)3.31815648
13Dialeptic seizures (HP:0011146)3.25634554
14Generalized tonic-clonic seizures (HP:0002069)3.24052396
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.06173872
16Absent/shortened dynein arms (HP:0200106)3.06173872
17Abnormal hair whorl (HP:0010721)3.05370606
18Ankle clonus (HP:0011448)3.03539279
19Absent speech (HP:0001344)3.02125735
20Volvulus (HP:0002580)3.01915091
21Genetic anticipation (HP:0003743)2.95764686
22Excessive salivation (HP:0003781)2.91623572
23Drooling (HP:0002307)2.91623572
24Medial flaring of the eyebrow (HP:0010747)2.87851108
25Protruding tongue (HP:0010808)2.86602769
26Amyotrophic lateral sclerosis (HP:0007354)2.76765842
27Gait imbalance (HP:0002141)2.75897970
28Urinary bladder sphincter dysfunction (HP:0002839)2.62792320
29Dysdiadochokinesis (HP:0002075)2.60502027
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.59286478
31Intention tremor (HP:0002080)2.53747072
32Impaired vibration sensation in the lower limbs (HP:0002166)2.52206297
33Congenital primary aphakia (HP:0007707)2.49559563
34Truncal ataxia (HP:0002078)2.48259838
35Progressive inability to walk (HP:0002505)2.47159527
36Cerebral hypomyelination (HP:0006808)2.39718442
37Papilledema (HP:0001085)2.33020061
38Abnormal eating behavior (HP:0100738)2.32082944
39Scanning speech (HP:0002168)2.31880023
40Inability to walk (HP:0002540)2.31814646
41Amblyopia (HP:0000646)2.30385804
42Abnormal respiratory motile cilium physiology (HP:0012261)2.30208461
43Dysmetria (HP:0001310)2.29875502
44Nephrogenic diabetes insipidus (HP:0009806)2.28848917
45Action tremor (HP:0002345)2.27318210
46Poor eye contact (HP:0000817)2.26631661
47Abnormal ciliary motility (HP:0012262)2.26476744
48Blue irides (HP:0000635)2.26340412
49Depression (HP:0000716)2.26074341
50Hemiparesis (HP:0001269)2.24700760
51Oligodactyly (hands) (HP:0001180)2.23782815
52Fetal akinesia sequence (HP:0001989)2.23415182
53Delusions (HP:0000746)2.21177705
54Epileptiform EEG discharges (HP:0011182)2.20765766
55Impaired smooth pursuit (HP:0007772)2.20488166
56Lissencephaly (HP:0001339)2.17703757
57Papillary thyroid carcinoma (HP:0002895)2.16515683
58Hemiplegia (HP:0002301)2.14377072
59Medulloblastoma (HP:0002885)2.11212008
60Supranuclear gaze palsy (HP:0000605)2.10863755
61Abnormal respiratory epithelium morphology (HP:0012253)2.09514118
62Abnormal respiratory motile cilium morphology (HP:0005938)2.09514118
63Spastic gait (HP:0002064)2.06415189
64Morphological abnormality of the pyramidal tract (HP:0002062)2.05730838
65Polyphagia (HP:0002591)2.05523872
66Abnormality of salivation (HP:0100755)2.05263992
67Limb dystonia (HP:0002451)2.05212137
68EEG with generalized epileptiform discharges (HP:0011198)2.04255401
69Genital tract atresia (HP:0001827)2.03516703
70Retinal dysplasia (HP:0007973)2.00770781
71Spastic tetraplegia (HP:0002510)1.97710183
72Split foot (HP:0001839)1.97068027
73Lower limb muscle weakness (HP:0007340)1.97048264
74Vaginal atresia (HP:0000148)1.96823807
75Nephronophthisis (HP:0000090)1.95993438
76Diplopia (HP:0000651)1.94644984
77Abnormality of binocular vision (HP:0011514)1.94644984
78Anxiety (HP:0000739)1.93839933
79Poor coordination (HP:0002370)1.92154873
80Postural instability (HP:0002172)1.92127416
81Intestinal atresia (HP:0011100)1.91885164
82Widely spaced teeth (HP:0000687)1.91705406
83Specific learning disability (HP:0001328)1.91038569
84Abnormality of the astrocytes (HP:0100707)1.90836093
85Astrocytoma (HP:0009592)1.90836093
86Failure to thrive in infancy (HP:0001531)1.90805573
87Abnormality of ocular smooth pursuit (HP:0000617)1.89671107
88Status epilepticus (HP:0002133)1.89536756
89Impaired vibratory sensation (HP:0002495)1.89474091
90Aplasia/Hypoplasia of the lens (HP:0008063)1.89112078
91Generalized hypopigmentation of hair (HP:0011358)1.88373110
92Glioma (HP:0009733)1.88036724
93Hypsarrhythmia (HP:0002521)1.83180943
94Abnormal social behavior (HP:0012433)1.82332271
95Impaired social interactions (HP:0000735)1.82332271
96Hip dysplasia (HP:0001385)1.81156981
97Aqueductal stenosis (HP:0002410)1.79970940
98Akinesia (HP:0002304)1.79769354
99Tetraplegia (HP:0002445)1.79696896
100Decreased circulating renin level (HP:0003351)1.78919088
101CNS hypomyelination (HP:0003429)1.78666412
102Abnormality of the lower motor neuron (HP:0002366)1.77869935
103Agitation (HP:0000713)1.77140877
104Urinary urgency (HP:0000012)1.76559133
105Dysmetric saccades (HP:0000641)1.74445425
106Peripheral hypomyelination (HP:0007182)1.74396875
107Inappropriate behavior (HP:0000719)1.74136202
108Molar tooth sign on MRI (HP:0002419)1.73846749
109Abnormality of midbrain morphology (HP:0002418)1.73846749
110Pancreatic fibrosis (HP:0100732)1.73643266
111Megalencephaly (HP:0001355)1.72891224
112Torticollis (HP:0000473)1.72286240
113Heterochromia iridis (HP:0001100)1.72248472
114Stereotypic behavior (HP:0000733)1.72021763
115Pheochromocytoma (HP:0002666)1.72001929
116Rhinitis (HP:0012384)1.71184210
117Abnormality of the corticospinal tract (HP:0002492)1.70946797
118Bradykinesia (HP:0002067)1.70885272
119Absent eyebrow (HP:0002223)1.70875178
120Sleep apnea (HP:0010535)1.70029164
121Paraplegia (HP:0010550)1.69617393
122Hypothermia (HP:0002045)1.69346834
123Truncal obesity (HP:0001956)1.69142809
124Tubulointerstitial nephritis (HP:0001970)1.68691782
125Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68519664
126Fair hair (HP:0002286)1.68274492
127Mutism (HP:0002300)1.65710731
128Thickened helices (HP:0000391)1.65487100
129Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65273477
130Degeneration of the lateral corticospinal tracts (HP:0002314)1.65273477
131Abnormality of the labia minora (HP:0012880)1.62350519
132Gastroesophageal reflux (HP:0002020)1.61076406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.59082639
2NTRK33.76128750
3EPHA43.32240483
4MAP3K43.04589655
5MAP2K72.99352458
6MARK12.71990404
7TNIK2.33308246
8MAP3K122.17570040
9MAP3K92.07148396
10MINK12.05632791
11NTRK22.02542365
12PRPF4B1.96429736
13TRIM281.91045941
14PLK21.88128167
15PRKD31.81120794
16AKT31.74583769
17SGK21.73867757
18MAPK131.73193228
19DAPK21.70372215
20PNCK1.62215478
21MAP2K41.62073580
22PAK61.61152188
23SGK2231.50294888
24SGK4941.50294888
25KSR11.45846458
26RIPK41.43972936
27BMPR21.38461918
28CDK51.22437301
29CCNB11.16042585
30SIK31.15032983
31CDK191.13039346
32PRKCG1.10170730
33DAPK11.10141751
34FES1.09045345
35GRK51.06290426
36STK381.05903791
37CAMKK21.04515941
38SGK31.03510962
39ERBB31.03065255
40DYRK21.02205705
41DYRK1A0.99891336
42CAMKK10.95665145
43CAMK2A0.95605608
44CSNK1G30.94515837
45EPHA30.94385409
46PLK40.90770585
47CSNK1A1L0.90245154
48UHMK10.90144178
49STK38L0.89359722
50MKNK20.88721069
51CDK30.85841151
52NEK60.85782842
53KSR20.83040189
54WNK30.82581770
55MAP4K20.82471384
56OXSR10.81645703
57NTRK10.80923430
58CSNK1G10.80691510
59INSRR0.79977785
60SGK10.79962412
61FRK0.79645989
62TNK20.79077405
63PINK10.79016204
64PRKCE0.77816314
65BRAF0.77651385
66BMPR1B0.75355055
67CAMK1G0.74918063
68MAP3K60.74485041
69BCR0.74201984
70CAMK2B0.72751125
71SIK20.71913189
72TYRO30.70123843
73CSNK1G20.69248334
74PHKG20.69053137
75PHKG10.69053137
76CDK180.67837577
77CAMK10.67527799
78ARAF0.66274580
79PTK2B0.64086341
80WNK10.64011301
81LATS20.62583486
82PRKCZ0.61179174
83CDK150.59342795
84MAP3K20.58277254
85PDK30.57316590
86PDK40.57316590
87PRKCH0.56981078
88MARK20.56261760
89MUSK0.55712609
90RAF10.53966694
91CDK80.53819240
92CDK140.52768970
93STK110.51973356
94CAMK40.51904159
95IRAK20.51724032
96PAK30.51589406
97CAMK2D0.51087073
98ERBB20.50818108
99CSNK1D0.50612834
100CDK11A0.49451202
101PLK30.48617479
102FER0.48235126
103PKN10.45022160
104MAPK100.44149227
105TAOK30.43072703
106YES10.42758314
107ADRBK20.41694535
108ROCK20.40769412
109GRK70.40339175
110RPS6KA30.39994700
111PRKG10.39082371
112GRK10.37839185
113RPS6KB10.36812758
114CDC42BPA0.36772767
115WEE10.36739212
116CSNK1E0.36226761
117FYN0.35375172
118FGFR20.35162828
119RET0.34010463
120BRSK10.33055353
121PRKACA0.32047318

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.84445982
2Synaptic vesicle cycle_Homo sapiens_hsa047213.14842525
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70223362
4Olfactory transduction_Homo sapiens_hsa047402.57852795
5Circadian entrainment_Homo sapiens_hsa047132.57688061
6Morphine addiction_Homo sapiens_hsa050322.56369400
7GABAergic synapse_Homo sapiens_hsa047272.55074832
8Long-term potentiation_Homo sapiens_hsa047202.50788881
9Glutamatergic synapse_Homo sapiens_hsa047242.46563189
10Amphetamine addiction_Homo sapiens_hsa050312.44881452
11Dopaminergic synapse_Homo sapiens_hsa047282.13366307
12Insulin secretion_Homo sapiens_hsa049112.11291989
13Taste transduction_Homo sapiens_hsa047422.08423329
14Serotonergic synapse_Homo sapiens_hsa047261.91030243
15Collecting duct acid secretion_Homo sapiens_hsa049661.89021095
16Salivary secretion_Homo sapiens_hsa049701.84100440
17Cholinergic synapse_Homo sapiens_hsa047251.76258228
18Renin secretion_Homo sapiens_hsa049241.73314002
19Long-term depression_Homo sapiens_hsa047301.73188753
20Cocaine addiction_Homo sapiens_hsa050301.68180285
21Phototransduction_Homo sapiens_hsa047441.63905477
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59306232
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55690534
24Gastric acid secretion_Homo sapiens_hsa049711.54320902
25Calcium signaling pathway_Homo sapiens_hsa040201.52007350
26Oxytocin signaling pathway_Homo sapiens_hsa049211.51272959
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40500866
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38873593
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38149909
30cAMP signaling pathway_Homo sapiens_hsa040241.30374508
31Vibrio cholerae infection_Homo sapiens_hsa051101.29559362
32GnRH signaling pathway_Homo sapiens_hsa049121.28426344
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23047011
34Axon guidance_Homo sapiens_hsa043601.17918136
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17282417
36Gap junction_Homo sapiens_hsa045401.14390370
37Type II diabetes mellitus_Homo sapiens_hsa049301.10011086
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08742399
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07448603
40Melanogenesis_Homo sapiens_hsa049161.04680140
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04669886
42Oocyte meiosis_Homo sapiens_hsa041141.04149664
43Estrogen signaling pathway_Homo sapiens_hsa049151.03522999
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.99706713
45ErbB signaling pathway_Homo sapiens_hsa040120.99673876
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99182213
47Regulation of autophagy_Homo sapiens_hsa041400.97788186
48Circadian rhythm_Homo sapiens_hsa047100.93036943
49Basal transcription factors_Homo sapiens_hsa030220.90456716
50Glioma_Homo sapiens_hsa052140.88765328
51Dorso-ventral axis formation_Homo sapiens_hsa043200.86947999
52Cardiac muscle contraction_Homo sapiens_hsa042600.82573147
53MAPK signaling pathway_Homo sapiens_hsa040100.80282179
54Fatty acid biosynthesis_Homo sapiens_hsa000610.78781751
55Type I diabetes mellitus_Homo sapiens_hsa049400.72760394
56Dilated cardiomyopathy_Homo sapiens_hsa054140.71862536
57Pancreatic secretion_Homo sapiens_hsa049720.71444399
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71313788
59Glucagon signaling pathway_Homo sapiens_hsa049220.70960231
60Choline metabolism in cancer_Homo sapiens_hsa052310.70310355
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70305002
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70280387
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69896604
64Wnt signaling pathway_Homo sapiens_hsa043100.69432783
65Thyroid hormone synthesis_Homo sapiens_hsa049180.67809670
66Ras signaling pathway_Homo sapiens_hsa040140.67371743
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.67062730
68Inositol phosphate metabolism_Homo sapiens_hsa005620.63330795
69Alcoholism_Homo sapiens_hsa050340.63213695
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61831738
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61238454
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61016071
73Ovarian steroidogenesis_Homo sapiens_hsa049130.60972106
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59292340
75Endometrial cancer_Homo sapiens_hsa052130.58962781
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55368072
77Rheumatoid arthritis_Homo sapiens_hsa053230.52748134
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52407068
79Protein export_Homo sapiens_hsa030600.52157399
80Hippo signaling pathway_Homo sapiens_hsa043900.51834996
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51322243
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50779364
83Butanoate metabolism_Homo sapiens_hsa006500.48467057
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.48029344
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47600406
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.47101069
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46680992
88mRNA surveillance pathway_Homo sapiens_hsa030150.46575927
89Rap1 signaling pathway_Homo sapiens_hsa040150.46503548
90Alzheimers disease_Homo sapiens_hsa050100.46168867
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44818453
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42866218
93Non-small cell lung cancer_Homo sapiens_hsa052230.42628116
94Oxidative phosphorylation_Homo sapiens_hsa001900.41705275
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39944027
96Fanconi anemia pathway_Homo sapiens_hsa034600.39324164
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38713074
98Renal cell carcinoma_Homo sapiens_hsa052110.38522821
99Hedgehog signaling pathway_Homo sapiens_hsa043400.37930829
100Colorectal cancer_Homo sapiens_hsa052100.37459346
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37245722
102Insulin signaling pathway_Homo sapiens_hsa049100.36369312
103Tight junction_Homo sapiens_hsa045300.36097103
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35934288
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34935541
106Melanoma_Homo sapiens_hsa052180.33788326
107Propanoate metabolism_Homo sapiens_hsa006400.32579825
108VEGF signaling pathway_Homo sapiens_hsa043700.32512125
109Huntingtons disease_Homo sapiens_hsa050160.32408378
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32206777
111Phagosome_Homo sapiens_hsa041450.32105805
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31788336
113FoxO signaling pathway_Homo sapiens_hsa040680.31644332
114Chemokine signaling pathway_Homo sapiens_hsa040620.31552012
115Endocytosis_Homo sapiens_hsa041440.31355428
116Prolactin signaling pathway_Homo sapiens_hsa049170.29989075
117mTOR signaling pathway_Homo sapiens_hsa041500.28668622

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