ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	substrate-independent telencephalic tangential migration (GO:0021826)	7.03269313
2	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	7.03269313
3	behavioral response to nicotine (GO:0035095)	4.91377192
4	epithelial cilium movement (GO:0003351)	4.47034429
5	response to parathyroid hormone (GO:0071107)	4.36064685
6	left/right pattern formation (GO:0060972)	4.29964155
7	GTP biosynthetic process (GO:0006183)	4.18963669
8	neuron recognition (GO:0008038)	4.16647749
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.15851494
10	axonal fasciculation (GO:0007413)	3.99320294
11	dendritic spine morphogenesis (GO:0060997)	3.98972191
12	cilium movement (GO:0003341)	3.97616911
13	body morphogenesis (GO:0010171)	3.92254367
14	pyrimidine nucleobase catabolic process (GO:0006208)	3.84990660
15	spinal cord association neuron differentiation (GO:0021527)	3.83989895
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.82959947
17	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.82719837
18	axonemal dynein complex assembly (GO:0070286)	3.81572979
19	auditory behavior (GO:0031223)	3.52292916
20	positive regulation of gastrulation (GO:2000543)	3.52244376
21	UTP metabolic process (GO:0046051)	3.52071717
22	mechanosensory behavior (GO:0007638)	3.51630227
23	UTP biosynthetic process (GO:0006228)	3.50595412
24	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.50568287
25	ATP synthesis coupled proton transport (GO:0015986)	3.48195817
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.48195817
27	neurofilament cytoskeleton organization (GO:0060052)	3.44734915
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.44192590
29	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.43862177
30	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.37453631
31	response to histamine (GO:0034776)	3.36882969
32	tachykinin receptor signaling pathway (GO:0007217)	3.35878944
33	regulation of cilium movement (GO:0003352)	3.34337956
34	embryonic body morphogenesis (GO:0010172)	3.28932631
35	presynaptic membrane organization (GO:0097090)	3.28698677
36	behavioral response to ethanol (GO:0048149)	3.27748474
37	axon extension (GO:0048675)	3.26776855
38	cell proliferation in forebrain (GO:0021846)	3.23961378
39	receptor recycling (GO:0001881)	3.22748363
40	auditory receptor cell differentiation (GO:0042491)	3.20472857
41	ganglion development (GO:0061548)	3.19570932
42	retinal ganglion cell axon guidance (GO:0031290)	3.10427240
43	membrane repolarization during action potential (GO:0086011)	3.10209641
44	regulation of synapse structural plasticity (GO:0051823)	3.09190475
45	CTP metabolic process (GO:0046036)	3.08936464
46	CTP biosynthetic process (GO:0006241)	3.08936464
47	axon ensheathment in central nervous system (GO:0032291)	3.07524119
48	central nervous system myelination (GO:0022010)	3.07524119
49	adult walking behavior (GO:0007628)	3.04454500
50	protein polyglutamylation (GO:0018095)	2.99156922
51	chaperone-mediated protein transport (GO:0072321)	2.99045247
52	neuronal ion channel clustering (GO:0045161)	2.98039135
53	viral transcription (GO:0019083)	2.94782841
54	cerebral cortex radially oriented cell migration (GO:0021799)	2.94659629
55	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.92117650
56	locomotory exploration behavior (GO:0035641)	2.91523618
57	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.91151572
58	nucleobase catabolic process (GO:0046113)	2.91113024
59	cell migration in hindbrain (GO:0021535)	2.91000346
60	translational termination (GO:0006415)	2.90358175
61	regulation of membrane repolarization (GO:0060306)	2.88093105
62	parturition (GO:0007567)	2.86984532
63	postsynaptic membrane organization (GO:0001941)	2.85205924
64	protein localization to synapse (GO:0035418)	2.84881650
65	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.83254542
66	neuron migration (GO:0001764)	2.82751869
67	intraciliary transport (GO:0042073)	2.81373917
68	transmission of nerve impulse (GO:0019226)	2.81200483
69	exploration behavior (GO:0035640)	2.79502984
70	membrane repolarization (GO:0086009)	2.79211673
71	establishment of mitochondrion localization (GO:0051654)	2.78754843
72	nonmotile primary cilium assembly (GO:0035058)	2.76228432
73	regulation of microtubule-based movement (GO:0060632)	2.75303597
74	spinal cord development (GO:0021510)	2.74668721
75	head development (GO:0060322)	2.72701825
76	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.71694770
77	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.71229469
78	forebrain neuron differentiation (GO:0021879)	2.70229038
79	central nervous system projection neuron axonogenesis (GO:0021952)	2.67817698
80	synapse assembly (GO:0007416)	2.67461546
81	positive regulation of growth hormone secretion (GO:0060124)	2.66554611
82	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.65672013
83	neuronal stem cell maintenance (GO:0097150)	2.64107359
84	mitochondrion transport along microtubule (GO:0047497)	2.63645312
85	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.63645312
86	ovulation cycle (GO:0042698)	2.63467363
87	inner ear receptor cell development (GO:0060119)	2.63040840
88	short-term memory (GO:0007614)	2.61579574
89	neuron projection extension (GO:1990138)	2.61463442
90	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61122305
91	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.60845979
92	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.60635437
93	genetic imprinting (GO:0071514)	2.60625232
94	negative regulation of Ras GTPase activity (GO:0034261)	2.58387098
95	retina layer formation (GO:0010842)	2.57480396
96	regulation of receptor binding (GO:1900120)	2.57348460
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.57292392
98	protein neddylation (GO:0045116)	2.57077940
99	regulation of potassium ion transmembrane transport (GO:1901379)	2.57064391
100	synaptic vesicle maturation (GO:0016188)	2.56767671

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.32952359
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.90245154
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.70638126
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.35163555
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	3.03497485
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.02191250
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.85783190
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.61299538
9	REST_21632747_ChIP-Seq_MESCs_Mouse	2.60603216
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.55756706
11	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.43093587
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.33076432
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.30835030
14	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.28157953
15	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.28157953
16	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.26427055
17	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.26014734
18	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.25698404
19	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.25525529
20	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.24816308
21	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.09408906
22	RNF2_27304074_Chip-Seq_NSC_Mouse	2.07842872
23	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.05235225
24	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.02581631
25	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.93372369
26	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.86215587
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.86215587
28	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.84678786
29	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.82840736
30	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.82339634
31	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.72670797
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69405687
33	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.68344453
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62769343
35	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.57107911
36	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.53878506
37	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.53125434
38	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.49098109
39	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42630193
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41348116
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38212658
42	ZNF274_21170338_ChIP-Seq_K562_Hela	1.33723033
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.33316307
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.32935182
45	CTCF_27219007_Chip-Seq_Bcells_Human	1.31929949
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29488179
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26177050
48	VDR_22108803_ChIP-Seq_LS180_Human	1.24753451
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.23106875
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22900710
51	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.21260930
52	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.19521955
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18302305
54	FUS_26573619_Chip-Seq_HEK293_Human	1.17179878
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15605194
56	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.14567124
57	GBX2_23144817_ChIP-Seq_PC3_Human	1.14004982
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13376202
59	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.13009870
60	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.11083649
61	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10302675
62	DROSHA_22980978_ChIP-Seq_HELA_Human	1.09377981
63	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.08964207
64	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.06873128
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.04845010
66	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.04258315
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.01181434
68	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00213578
69	AR_25329375_ChIP-Seq_VCAP_Human	0.98724330
70	P300_19829295_ChIP-Seq_ESCs_Human	0.98342982
71	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.96705632
72	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95188010
73	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.94786564
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.94259677
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94062613
76	JUN_21703547_ChIP-Seq_K562_Human	0.93796326
77	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.93524677
78	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.92441615
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92395970
80	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91691103
81	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.91464040
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.89975239
83	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.89278033
84	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.88573781
85	RUNX2_22187159_ChIP-Seq_PCA_Human	0.88418265
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.88250025
87	HTT_18923047_ChIP-ChIP_STHdh_Human	0.87690961
88	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.86945079
89	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86570767
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85652931
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.84921354
92	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.84921354
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.83291884
94	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.81940933
95	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81391710
96	NCOR_22424771_ChIP-Seq_293T_Human	0.81370238
97	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.81137727
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.80495156
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.80478963
100	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.80432701

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003123_paternal_imprinting	5.14106814
2	MP0003787_abnormal_imprinting	5.02614474
3	MP0005423_abnormal_somatic_nervous	3.26257485
4	MP0003121_genomic_imprinting	3.19067549
5	MP0003880_abnormal_central_pattern	3.09871139
6	MP0003122_maternal_imprinting	2.87937417
7	MP0006292_abnormal_olfactory_placode	2.84327987
8	MP0002653_abnormal_ependyma_morphology	2.75754565
9	MP0000778_abnormal_nervous_system	2.66538345
10	MP0002822_catalepsy	2.65742653
11	MP0001188_hyperpigmentation	2.60245272
12	MP0006276_abnormal_autonomic_nervous	2.39909539
13	MP0000569_abnormal_digit_pigmentation	2.29174199
14	MP0008877_abnormal_DNA_methylation	2.27632805
15	MP0004859_abnormal_synaptic_plasticity	2.16757138
16	MP0009379_abnormal_foot_pigmentation	2.10819440
17	MP0002163_abnormal_gland_morphology	2.06449936
18	MP0002272_abnormal_nervous_system	1.90388700
19	MP0008789_abnormal_olfactory_epithelium	1.86146605
20	MP0002184_abnormal_innervation	1.80120245
21	MP0004885_abnormal_endolymph	1.76857841
22	MP0004145_abnormal_muscle_electrophysio	1.72676878
23	MP0000955_abnormal_spinal_cord	1.67350825
24	MP0009745_abnormal_behavioral_response	1.66628569
25	MP0001440_abnormal_grooming_behavior	1.66313626
26	MP0005394_taste/olfaction_phenotype	1.64808207
27	MP0005499_abnormal_olfactory_system	1.64808207
28	MP0003635_abnormal_synaptic_transmissio	1.61588161
29	MP0002160_abnormal_reproductive_system	1.59150109
30	MP0002557_abnormal_social/conspecific_i	1.58754759
31	MP0002063_abnormal_learning/memory/cond	1.54776075
32	MP0005646_abnormal_pituitary_gland	1.49296566
33	MP0002736_abnormal_nociception_after	1.49276519
34	MP0002572_abnormal_emotion/affect_behav	1.48787712
35	MP0004858_abnormal_nervous_system	1.47173718
36	MP0003011_delayed_dark_adaptation	1.45355049
37	MP0005379_endocrine/exocrine_gland_phen	1.43331776
38	MP0002733_abnormal_thermal_nociception	1.40172797
39	MP0001970_abnormal_pain_threshold	1.39502506
40	MP0004742_abnormal_vestibular_system	1.37692540
41	MP0002752_abnormal_somatic_nervous	1.36312624
42	MP0002067_abnormal_sensory_capabilities	1.36206364
43	MP0001968_abnormal_touch/_nociception	1.35494787
44	MP0001529_abnormal_vocalization	1.33154794
45	MP0002882_abnormal_neuron_morphology	1.31808673
46	MP0002638_abnormal_pupillary_reflex	1.30892700
47	MP0004142_abnormal_muscle_tone	1.29740371
48	MP0001905_abnormal_dopamine_level	1.28356128
49	MP0002734_abnormal_mechanical_nocicepti	1.26665540
50	MP0004133_heterotaxia	1.25937113
51	MP0003879_abnormal_hair_cell	1.25272753
52	MP0002064_seizures	1.24849342
53	MP0003942_abnormal_urinary_system	1.23517120
54	MP0001485_abnormal_pinna_reflex	1.23246862
55	MP0000631_abnormal_neuroendocrine_gland	1.19396220
56	MP0009046_muscle_twitch	1.18297185
57	MP0004811_abnormal_neuron_physiology	1.17109887
58	MP0005551_abnormal_eye_electrophysiolog	1.15233920
59	MP0003890_abnormal_embryonic-extraembry	1.12905010
60	MP0001486_abnormal_startle_reflex	1.12111088
61	MP0000026_abnormal_inner_ear	1.10266396
62	MP0005195_abnormal_posterior_eye	1.08729287
63	MP0005389_reproductive_system_phenotype	1.07422183
64	MP0000534_abnormal_ureter_morphology	1.06709626
65	MP0001919_abnormal_reproductive_system	1.05382548
66	MP0005645_abnormal_hypothalamus_physiol	1.04868369
67	MP0001984_abnormal_olfaction	1.04789882
68	MP0002152_abnormal_brain_morphology	1.03863922
69	MP0003315_abnormal_perineum_morphology	1.02324584
70	MP0004270_analgesia	0.96724841
71	MP0006072_abnormal_retinal_apoptosis	0.96541789
72	MP0002735_abnormal_chemical_nociception	0.95807211
73	MP0005409_darkened_coat_color	0.95228300
74	MP0001986_abnormal_taste_sensitivity	0.95214606
75	MP0005084_abnormal_gallbladder_morpholo	0.93167233
76	MP0003646_muscle_fatigue	0.92929847
77	MP0001286_abnormal_eye_development	0.92300095
78	MP0003861_abnormal_nervous_system	0.90182450
79	MP0000049_abnormal_middle_ear	0.88258134
80	MP0004924_abnormal_behavior	0.84850508
81	MP0005386_behavior/neurological_phenoty	0.84850508
82	MP0001293_anophthalmia	0.84756383
83	MP0002229_neurodegeneration	0.84025195
84	MP0001963_abnormal_hearing_physiology	0.83907257
85	MP0003119_abnormal_digestive_system	0.83076810
86	MP0002066_abnormal_motor_capabilities/c	0.81143962
87	MP0002909_abnormal_adrenal_gland	0.79060038
88	MP0000427_abnormal_hair_cycle	0.78887641
89	MP0002928_abnormal_bile_duct	0.78823450
90	MP0008569_lethality_at_weaning	0.78455922
91	MP0003878_abnormal_ear_physiology	0.78447415
92	MP0005377_hearing/vestibular/ear_phenot	0.78447415
93	MP0002234_abnormal_pharynx_morphology	0.77707571
94	MP0001879_abnormal_lymphatic_vessel	0.75370644
95	MP0001542_abnormal_bone_strength	0.75033151
96	MP0003938_abnormal_ear_development	0.74223573
97	MP0004147_increased_porphyrin_level	0.73001317
98	MP0002102_abnormal_ear_morphology	0.69924154
99	MP0002233_abnormal_nose_morphology	0.69896999
100	MP0002938_white_spotting	0.68856919

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	4.39891597
2	Abnormal ciliary motility (HP:0012262)	4.33303086
3	Abnormal hair whorl (HP:0010721)	3.79542983
4	Abnormal respiratory motile cilium physiology (HP:0012261)	3.52030322
5	Limb dystonia (HP:0002451)	3.25159937
6	Deep palmar crease (HP:0006191)	3.22908901
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.14933358
8	Absent/shortened dynein arms (HP:0200106)	3.14933358
9	Abnormal pancreas size (HP:0012094)	3.14198506
10	Osteomalacia (HP:0002749)	3.11574962
11	Polyphagia (HP:0002591)	3.00924581
12	Gait imbalance (HP:0002141)	2.96027005
13	Congenital stationary night blindness (HP:0007642)	2.91977981
14	Hepatoblastoma (HP:0002884)	2.91645120
15	Abnormality of midbrain morphology (HP:0002418)	2.90105839
16	Molar tooth sign on MRI (HP:0002419)	2.90105839
17	Nephronophthisis (HP:0000090)	2.89955747
18	Acute necrotizing encephalopathy (HP:0006965)	2.78831297
19	Progressive cerebellar ataxia (HP:0002073)	2.75945351
20	Agitation (HP:0000713)	2.75133209
21	Medial flaring of the eyebrow (HP:0010747)	2.74811810
22	Hypogonadotrophic hypogonadism (HP:0000044)	2.74035952
23	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.62993880
24	Neoplasm of the adrenal cortex (HP:0100641)	2.52119897
25	Acute encephalopathy (HP:0006846)	2.52100303
26	Abnormality of the renal medulla (HP:0100957)	2.51270500
27	Abnormality of cells of the erythroid lineage (HP:0012130)	2.49596851
28	Lissencephaly (HP:0001339)	2.47001023
29	Pachygyria (HP:0001302)	2.45465734
30	Congenital primary aphakia (HP:0007707)	2.44774283
31	Diastasis recti (HP:0001540)	2.44698967
32	Adrenal hypoplasia (HP:0000835)	2.43695201
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.41875142
34	Metaphyseal dysplasia (HP:0100255)	2.41541519
35	Abnormal respiratory motile cilium morphology (HP:0005938)	2.40512693
36	Abnormal respiratory epithelium morphology (HP:0012253)	2.40512693
37	Growth hormone deficiency (HP:0000824)	2.37256345
38	Nephrogenic diabetes insipidus (HP:0009806)	2.35744172
39	Anomalous pulmonary venous return (HP:0010772)	2.33798006
40	Sleep apnea (HP:0010535)	2.33536532
41	Septo-optic dysplasia (HP:0100842)	2.33516302
42	Progressive macrocephaly (HP:0004481)	2.32824682
43	Shawl scrotum (HP:0000049)	2.32647913
44	Pancreatic fibrosis (HP:0100732)	2.31373655
45	Hyperthyroidism (HP:0000836)	2.30936526
46	Congenital, generalized hypertrichosis (HP:0004540)	2.30897852
47	Poor coordination (HP:0002370)	2.29502714
48	Drooling (HP:0002307)	2.29165123
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.26120957
50	Broad-based gait (HP:0002136)	2.24565381
51	Rib fusion (HP:0000902)	2.21365159
52	Impulsivity (HP:0100710)	2.20304130
53	Hyperglycinemia (HP:0002154)	2.18104588
54	Thyroid-stimulating hormone excess (HP:0002925)	2.15462700
55	Spastic tetraplegia (HP:0002510)	2.14504623
56	Slow-growing hair (HP:0002217)	2.12670837
57	Abnormality of hair growth rate (HP:0011363)	2.12670837
58	Bony spicule pigmentary retinopathy (HP:0007737)	2.11514080
59	Hip dysplasia (HP:0001385)	2.10689985
60	True hermaphroditism (HP:0010459)	2.10538128
61	Chronic hepatic failure (HP:0100626)	2.10415297
62	Abnormality of the corticospinal tract (HP:0002492)	2.09182844
63	Macrocytic anemia (HP:0001972)	2.09059674
64	Reticulocytopenia (HP:0001896)	2.08623811
65	Specific learning disability (HP:0001328)	2.07829758
66	Excessive salivation (HP:0003781)	2.06966110
67	Anosmia (HP:0000458)	2.04088900
68	Oligodactyly (hands) (HP:0001180)	2.03771581
69	Poor suck (HP:0002033)	2.02177658
70	Abnormality of the labia minora (HP:0012880)	2.01320078
71	Mitochondrial inheritance (HP:0001427)	1.97243957
72	Cerebral hypomyelination (HP:0006808)	1.97050194
73	Abnormality of the pulmonary veins (HP:0011718)	1.96766461
74	Pallor (HP:0000980)	1.93832348
75	Narrow forehead (HP:0000341)	1.93408233
76	Anencephaly (HP:0002323)	1.91084869
77	Pancreatic cysts (HP:0001737)	1.89898465
78	Fetal akinesia sequence (HP:0001989)	1.89310026
79	Vaginal atresia (HP:0000148)	1.88231791
80	Genital tract atresia (HP:0001827)	1.88030057
81	Pendular nystagmus (HP:0012043)	1.87172962
82	Thickened helices (HP:0000391)	1.86399698
83	Abnormality of renal resorption (HP:0011038)	1.85494023
84	Abnormality of the aortic arch (HP:0012303)	1.82960246
85	Chorioretinal atrophy (HP:0000533)	1.79384940
86	Abnormal hemoglobin (HP:0011902)	1.75699998
87	Absent eyebrow (HP:0002223)	1.74848569
88	Morphological abnormality of the pyramidal tract (HP:0002062)	1.73662143
89	Infertility (HP:0000789)	1.71988565
90	Epileptic encephalopathy (HP:0200134)	1.71659792
91	Optic disc pallor (HP:0000543)	1.69969447
92	Abnormal number of erythroid precursors (HP:0012131)	1.67695006
93	Retinitis pigmentosa (HP:0000510)	1.67665289
94	Left ventricular hypertrophy (HP:0001712)	1.66249235
95	Abolished electroretinogram (ERG) (HP:0000550)	1.66182544
96	Focal dystonia (HP:0004373)	1.64971161
97	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.62421801
98	Abnormality of alanine metabolism (HP:0010916)	1.62421801
99	Hyperalaninemia (HP:0003348)	1.62421801
100	Short femoral neck (HP:0100864)	1.61990724

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.46977594
2	MARK1	3.34770433
3	BRAF	3.20755857
4	CASK	2.79754155
5	NTRK3	2.34610492
6	WNK4	2.15863967
7	MINK1	2.13343062
8	DYRK2	2.09232973
9	PNCK	2.05347337
10	PINK1	2.04973139
11	MAP3K4	1.99659651
12	MAPK15	1.95360285
13	MAP2K7	1.90561957
14	DMPK	1.71955257
15	SGK223	1.67210052
16	SGK494	1.67210052
17	MAP2K2	1.64418635
18	DYRK1B	1.57405450
19	ADRBK2	1.54963912
20	RPS6KA2	1.53593156
21	SGK2	1.52486264
22	PRKCG	1.50368644
23	TIE1	1.44820997
24	SIK2	1.44034149
25	DYRK3	1.43427550
26	PDK2	1.36137040
27	EPHB2	1.34639938
28	WNK3	1.32209414
29	MAP3K9	1.29117610
30	TYRO3	1.28184742
31	BMPR1B	1.24348677
32	CAMK1G	1.20995912
33	PAK3	1.19157319
34	EPHA4	1.16012206
35	NTRK2	1.15041324
36	MARK2	1.13739099
37	CAMK1D	1.08559369
38	MAPK13	1.06335589
39	TRIM28	1.06122494
40	EPHB1	1.05462019
41	CDK19	1.03638108
42	CDK5	1.01288115
43	ARAF	1.00546382
44	STK39	0.95638518
45	AKT3	0.95459519
46	RPS6KA6	0.95355862
47	SGK3	0.92416656
48	CAMKK1	0.91529738
49	DAPK2	0.89131295
50	STK11	0.86513036
51	MAP3K11	0.85900787
52	RPS6KC1	0.82268360
53	RPS6KL1	0.82268360
54	DYRK1A	0.82050122
55	PHKG1	0.81698476
56	PHKG2	0.81698476
57	TLK1	0.81521777
58	OXSR1	0.80076722
59	PIM2	0.78950074
60	CAMKK2	0.78805548
61	TAF1	0.77644528
62	GRK1	0.76423319
63	FRK	0.75744151
64	SGK1	0.71065820
65	CAMK4	0.70422481
66	ICK	0.68190857
67	PRKD3	0.68116714
68	CSNK1G2	0.66198150
69	CAMK2A	0.62903206
70	NUAK1	0.61387039
71	PRKACA	0.61055842
72	MAP2K4	0.60492535
73	CAMK1	0.59122113
74	CDK14	0.58327669
75	PIK3CA	0.55879894
76	PRKCQ	0.55788866
77	VRK1	0.54904303
78	ADRBK1	0.52928804
79	CDC7	0.49520680
80	PKN1	0.49461664
81	WNK1	0.48978589
82	TAOK3	0.48617991
83	PRKCZ	0.47496722
84	RPS6KA1	0.45044669
85	AKT1	0.45036251
86	CSNK1E	0.44657617
87	PRKG1	0.44530236
88	ZAK	0.44493366
89	NEK2	0.43002167
90	RPS6KA3	0.42688085
91	MUSK	0.42656558
92	TNIK	0.41731151
93	INSRR	0.40086326
94	ERBB2	0.37640426
95	PRKCD	0.36721012
96	CSNK1A1	0.36392124
97	PLK2	0.35280501
98	CDK15	0.35172501
99	RPS6KB1	0.34918079
100	CDK11A	0.34669175

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.58558839
2	Nicotine addiction_Homo sapiens_hsa05033	3.10742822
3	Cardiac muscle contraction_Homo sapiens_hsa04260	3.09491834
4	Ribosome_Homo sapiens_hsa03010	3.02751901
5	Parkinsons disease_Homo sapiens_hsa05012	3.01894592
6	Phototransduction_Homo sapiens_hsa04744	2.68290581
7	Alzheimers disease_Homo sapiens_hsa05010	2.15632410
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.12796194
9	Axon guidance_Homo sapiens_hsa04360	2.08213573
10	Huntingtons disease_Homo sapiens_hsa05016	1.96434873
11	Sulfur relay system_Homo sapiens_hsa04122	1.94894252
12	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.86131783
13	Morphine addiction_Homo sapiens_hsa05032	1.78063779
14	Insulin secretion_Homo sapiens_hsa04911	1.70026852
15	Cocaine addiction_Homo sapiens_hsa05030	1.68772629
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.62475929
17	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.58382692
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.57746402
19	GABAergic synapse_Homo sapiens_hsa04727	1.57537298
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56808159
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54755861
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.50920472
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47031748
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42723162
25	Olfactory transduction_Homo sapiens_hsa04740	1.39868250
26	Long-term depression_Homo sapiens_hsa04730	1.37166126
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.36650312
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.36520999
29	Basal cell carcinoma_Homo sapiens_hsa05217	1.36221018
30	Circadian entrainment_Homo sapiens_hsa04713	1.33655163
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.32570127
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.27327794
33	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.25373881
34	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.23791979
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.18627667
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16406125
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.15184188
38	Serotonergic synapse_Homo sapiens_hsa04726	1.13367304
39	Notch signaling pathway_Homo sapiens_hsa04330	1.13077514
40	Long-term potentiation_Homo sapiens_hsa04720	1.12852984
41	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.10713181
42	Taste transduction_Homo sapiens_hsa04742	1.10675741
43	Cholinergic synapse_Homo sapiens_hsa04725	1.07232563
44	RNA polymerase_Homo sapiens_hsa03020	1.04224824
45	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.02982497
46	Amphetamine addiction_Homo sapiens_hsa05031	1.00747369
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98592327
48	Caffeine metabolism_Homo sapiens_hsa00232	0.98097271
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.97393813
50	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.96218293
51	Peroxisome_Homo sapiens_hsa04146	0.95510699
52	Renin secretion_Homo sapiens_hsa04924	0.94868516
53	Protein export_Homo sapiens_hsa03060	0.94047016
54	Gap junction_Homo sapiens_hsa04540	0.86451539
55	Gastric acid secretion_Homo sapiens_hsa04971	0.86371940
56	Melanogenesis_Homo sapiens_hsa04916	0.81987272
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.77279454
58	Wnt signaling pathway_Homo sapiens_hsa04310	0.76235152
59	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.74735444
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.74364278
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73422214
62	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.71773922
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71627777
64	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.70601509
65	Retinol metabolism_Homo sapiens_hsa00830	0.66453933
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.65336111
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.65070361
68	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64479466
69	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.64434829
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.64072280
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.63701222
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.63615331
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.62678325
74	MAPK signaling pathway_Homo sapiens_hsa04010	0.62359992
75	Bile secretion_Homo sapiens_hsa04976	0.60105603
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59975703
77	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.59313535
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57777907
79	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56014181
80	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.55845670
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55351024
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.53946609
83	Salivary secretion_Homo sapiens_hsa04970	0.53397888
84	Mineral absorption_Homo sapiens_hsa04978	0.49479887
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47686758
86	Alcoholism_Homo sapiens_hsa05034	0.46922148
87	Homologous recombination_Homo sapiens_hsa03440	0.46129480
88	Pancreatic secretion_Homo sapiens_hsa04972	0.45901425
89	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.44577793
90	Ras signaling pathway_Homo sapiens_hsa04014	0.41079051
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.40351169
92	Butanoate metabolism_Homo sapiens_hsa00650	0.40038485
93	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39830232
94	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38348214
95	Melanoma_Homo sapiens_hsa05218	0.36980291
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35875964
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35364261
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34459079
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.33628538
100	Vibrio cholerae infection_Homo sapiens_hsa05110	0.32991196

SRPK2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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