SRPK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein kinase similar to a protein kinase which is specific for the SR (serine/arginine-rich domain) family of splicing factors. A highly similar protein has been shown to play a role in muscle development in mice. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)7.46904695
2actin-myosin filament sliding (GO:0033275)7.46904695
3cytidine catabolic process (GO:0006216)7.03052546
4cytidine deamination (GO:0009972)7.03052546
5cytidine metabolic process (GO:0046087)7.03052546
6response to muscle activity (GO:0014850)6.60632413
7sarcomere organization (GO:0045214)6.54657452
8skeletal muscle fiber development (GO:0048741)6.53087040
9actin-mediated cell contraction (GO:0070252)6.19870943
10cardiac myofibril assembly (GO:0055003)6.10927945
11myofibril assembly (GO:0030239)5.97099425
12myotube cell development (GO:0014904)5.96488526
13axon ensheathment in central nervous system (GO:0032291)5.77235569
14central nervous system myelination (GO:0022010)5.77235569
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.68855476
16pyrimidine ribonucleoside catabolic process (GO:0046133)5.48814436
17skeletal muscle adaptation (GO:0043501)5.31364901
18B cell receptor signaling pathway (GO:0050853)5.14505530
19muscle fiber development (GO:0048747)5.13965648
20regulation of skeletal muscle contraction (GO:0014819)5.11614169
21negative regulation of protein localization to cell surface (GO:2000009)5.01775062
22regulation of relaxation of muscle (GO:1901077)5.01512003
23negative regulation of potassium ion transmembrane transport (GO:1901380)4.98839603
24cardiac muscle contraction (GO:0060048)4.94426554
25actin filament-based movement (GO:0030048)4.86704251
26striated muscle atrophy (GO:0014891)4.83529439
27creatine metabolic process (GO:0006600)4.82352009
28striated muscle contraction (GO:0006941)4.66898793
29sarcoplasmic reticulum calcium ion transport (GO:0070296)4.61602917
30cardiac muscle tissue morphogenesis (GO:0055008)4.52875452
31adult heart development (GO:0007512)4.49518884
32* skeletal muscle tissue development (GO:0007519)4.41333999
33striated muscle adaptation (GO:0014888)4.40811651
34regulation of cell communication by electrical coupling (GO:0010649)4.40086764
35skeletal muscle contraction (GO:0003009)4.37204341
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.35386643
37muscle cell fate commitment (GO:0042693)4.34462681
38actomyosin structure organization (GO:0031032)4.34388345
39myelination (GO:0042552)4.32445170
40ensheathment of neurons (GO:0007272)4.32428604
41axon ensheathment (GO:0008366)4.32428604
42glycogen catabolic process (GO:0005980)4.32265000
43muscle atrophy (GO:0014889)4.29727369
44positive regulation of myotube differentiation (GO:0010831)4.25616559
45regulation of actin filament-based movement (GO:1903115)4.21400277
46muscle cell cellular homeostasis (GO:0046716)4.18775461
47response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.16055336
48regulation of sarcomere organization (GO:0060297)4.15949475
49skeletal muscle tissue regeneration (GO:0043403)4.14208045
50muscle organ development (GO:0007517)4.11177094
51ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.10971635
52muscle structure development (GO:0061061)4.09047003
53muscle tissue morphogenesis (GO:0060415)4.08987271
54glucan catabolic process (GO:0009251)3.99673802
55cardiac muscle cell development (GO:0055013)3.98397514
56glucan biosynthetic process (GO:0009250)3.97301300
57glycogen biosynthetic process (GO:0005978)3.97301300
58striated muscle cell development (GO:0055002)3.97146923
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.91191778
60cardiac muscle hypertrophy (GO:0003300)3.90772830
61mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.87171053
62regulation of striated muscle contraction (GO:0006942)3.86439095
63neuromuscular synaptic transmission (GO:0007274)3.82226512
64fatty acid elongation (GO:0030497)3.80460536
65regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.76028617
66regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.75960221
67neuronal action potential propagation (GO:0019227)3.75665665
68striated muscle hypertrophy (GO:0014897)3.74343987
69cellular response to zinc ion (GO:0071294)3.71965562
70cellular polysaccharide catabolic process (GO:0044247)3.70512845
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.69107089
72cardiac cell development (GO:0055006)3.65948346
73plasma membrane repair (GO:0001778)3.59579334
74response to inactivity (GO:0014854)3.58920295
75regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.58856109
76myoblast fusion (GO:0007520)3.54995691
77muscle adaptation (GO:0043500)3.53651651
78cellular response to epinephrine stimulus (GO:0071872)3.53307229
79positive regulation of myoblast differentiation (GO:0045663)3.52629600
80heart process (GO:0003015)3.51734745
81heart contraction (GO:0060047)3.51734745
82response to activity (GO:0014823)3.50531422
83response to epinephrine (GO:0071871)3.47769949
84regulation of cardioblast differentiation (GO:0051890)3.46627324
85ATP synthesis coupled proton transport (GO:0015986)3.46448460
86energy coupled proton transport, down electrochemical gradient (GO:0015985)3.46448460
872-oxoglutarate metabolic process (GO:0006103)3.43855098
88muscle cell development (GO:0055001)3.39635732
89polysaccharide catabolic process (GO:0000272)3.34214350
90myotube differentiation (GO:0014902)3.30465332
91negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.30014449
92negative regulation of calcium ion transmembrane transport (GO:1903170)3.30014449
93muscle organ morphogenesis (GO:0048644)3.29860253
94regulation of muscle system process (GO:0090257)3.29678958
95carnitine shuttle (GO:0006853)3.28836261
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27735544
97heart trabecula formation (GO:0060347)3.27328001
98regulation of the force of heart contraction (GO:0002026)3.24823710
99muscle hypertrophy (GO:0014896)3.24777666
100regulation of muscle contraction (GO:0006937)3.22627967
101NADH metabolic process (GO:0006734)3.22174900
102ubiquinone biosynthetic process (GO:0006744)3.18857048
103synaptic transmission, cholinergic (GO:0007271)3.16725950
104positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.16250039
105substantia nigra development (GO:0021762)3.15550505
106* striated muscle tissue development (GO:0014706)3.15065290
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.11754647
108muscle contraction (GO:0006936)3.11443148
109regulation of myoblast differentiation (GO:0045661)3.11334539
110regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10934824
111regulation of skeletal muscle cell differentiation (GO:2001014)3.10296223
112respiratory electron transport chain (GO:0022904)3.10110899
113activated T cell proliferation (GO:0050798)3.09235660
114syncytium formation by plasma membrane fusion (GO:0000768)3.09065194
115regulation of ATPase activity (GO:0043462)3.08200494
116regulation of ATP catabolic process (GO:1903289)3.08200494
117negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.05697033
118muscle hypertrophy in response to stress (GO:0003299)3.05624949
119cardiac muscle adaptation (GO:0014887)3.05624949
120cardiac muscle hypertrophy in response to stress (GO:0014898)3.05624949
121negative regulation of potassium ion transport (GO:0043267)3.05428012
122response to redox state (GO:0051775)3.05225593
123negative regulation of neurotransmitter secretion (GO:0046929)3.04578451
124tricarboxylic acid cycle (GO:0006099)3.03503370
125regulation of membrane repolarization (GO:0060306)3.03018927
126L-amino acid import (GO:0043092)3.02593635
127electron transport chain (GO:0022900)2.99109160
128regulation of calcium ion transmembrane transport (GO:1903169)2.97902165
129regulation of calcium ion transmembrane transporter activity (GO:1901019)2.97902165
130regulation of collateral sprouting (GO:0048670)2.97525209
131regulation of action potential (GO:0098900)2.96680034
132positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.96423760
133myelin maintenance (GO:0043217)2.94962174
134peripheral nervous system axon ensheathment (GO:0032292)2.93480718
135myelination in peripheral nervous system (GO:0022011)2.93480718
136locomotory exploration behavior (GO:0035641)2.92161407
137regulation of cardiac muscle cell differentiation (GO:2000725)2.88308061
138actin filament depolymerization (GO:0030042)2.87853314
139membrane tubulation (GO:0097320)2.86859689
140ventricular cardiac muscle cell action potential (GO:0086005)2.83315068
141L-glutamate transport (GO:0015813)2.80630803
142muscle system process (GO:0003012)2.79656306
143regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.77282350
144regulation of B cell receptor signaling pathway (GO:0050855)2.76840258
145eye photoreceptor cell differentiation (GO:0001754)2.71981587
146photoreceptor cell differentiation (GO:0046530)2.71981587
147regulation of cardiac muscle contraction (GO:0055117)2.70252749
148cellular response to catecholamine stimulus (GO:0071870)2.70012434
149cellular response to monoamine stimulus (GO:0071868)2.70012434
150B cell proliferation (GO:0042100)2.69056882
151acidic amino acid transport (GO:0015800)2.67923109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99637362
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.68633576
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.62489211
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34179126
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.17601088
6EZH2_22144423_ChIP-Seq_EOC_Human3.00916719
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.87841111
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.68528646
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.46299344
10AR_21572438_ChIP-Seq_LNCaP_Human2.39201650
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37612985
12MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.35516138
13TBX20_22328084_ChIP-Seq_HEART_Mouse2.34153871
14TBX20_22080862_ChIP-Seq_HEART_Mouse2.34153871
15SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.27600855
16VDR_22108803_ChIP-Seq_LS180_Human2.18459437
17CTCF_27219007_Chip-Seq_Bcells_Human2.14545227
18DROSHA_22980978_ChIP-Seq_HELA_Human2.10743360
19RUNX_20019798_ChIP-Seq_JUKART_Human2.07883655
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.05958971
21TAF15_26573619_Chip-Seq_HEK293_Human2.01970224
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93173966
23BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.92273191
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71556956
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69378256
26GBX2_23144817_ChIP-Seq_PC3_Human1.66116029
27IGF1R_20145208_ChIP-Seq_DFB_Human1.63824252
28NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.63352918
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61423088
30CTNNB1_20460455_ChIP-Seq_HCT116_Human1.60669182
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57516836
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54157978
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51256270
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50487723
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49998108
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.49307322
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.46152707
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44993432
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43622708
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42414206
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42224993
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.40857986
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.40733694
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38071625
45SA1_27219007_Chip-Seq_Bcells_Human1.37413932
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35266710
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33249187
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31650272
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.30385197
50P68_20966046_ChIP-Seq_HELA_Human1.29372349
51ER_23166858_ChIP-Seq_MCF-7_Human1.27731977
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27316590
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.25822551
54SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25466663
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24611922
56E2F1_20622854_ChIP-Seq_HELA_Human1.24337916
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24328220
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22915312
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22420309
60PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20543489
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20157479
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20067767
63KDM2B_26808549_Chip-Seq_DND41_Human1.19822019
64MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19370370
65AHR_22903824_ChIP-Seq_MCF-7_Human1.19217572
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.18884064
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18721281
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18721281
69CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18252798
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17835760
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17407776
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17255843
73SPI1_23127762_ChIP-Seq_K562_Human1.15968029
74P53_21459846_ChIP-Seq_SAOS-2_Human1.15769444
75MYC_27129775_Chip-Seq_CORNEA_Mouse1.15403320
76NANOG_20526341_ChIP-Seq_ESCs_Human1.14515669
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.14423340
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14342668
79OCT4_19829295_ChIP-Seq_ESCs_Human1.14289642
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.12436475
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12255219
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12066217
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11906905
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11892914
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11085587
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10849458
87MYC_19829295_ChIP-Seq_ESCs_Human1.10440368
88SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09695544
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09552878
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09307102
91VDR_24787735_ChIP-Seq_THP-1_Human1.08983110
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.08195272
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.06863200
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06670753
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05585837
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.05580435
97TBL1_22424771_ChIP-Seq_293T_Human1.05015777
98TCF4_23295773_ChIP-Seq_U87_Human1.04954360
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.04931445
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04846715
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04372728
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04035404
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.03421455
104SMRT_27268052_Chip-Seq_Bcells_Human1.03226479
105TP53_16413492_ChIP-PET_HCT116_Human1.03136772
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03124597
107ZNF274_21170338_ChIP-Seq_K562_Hela1.02795716
108BCL6_27268052_Chip-Seq_Bcells_Human1.02448881
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01709318
110TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00284259
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00176332
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99918136
113SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99732575
114KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98221037
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98052062
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97837666
117SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97295027
118LXR_22292898_ChIP-Seq_THP-1_Human0.96908086
119BCAT_22108803_ChIP-Seq_LS180_Human0.96545278
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96401729
121TAF2_19829295_ChIP-Seq_ESCs_Human0.96392697
122GATA1_19941826_ChIP-Seq_K562_Human0.96235685
123GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95936003
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95901988
125CTCF_26484167_Chip-Seq_Bcells_Mouse0.95752589
126CTCF_21964334_Chip-Seq_Bcells_Human0.95673863
127PHF8_20622854_ChIP-Seq_HELA_Human0.95655349
128IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94836846
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94520793
130FOXH1_21741376_ChIP-Seq_ESCs_Human0.94303011
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94021307
132SMAD4_21799915_ChIP-Seq_A2780_Human0.93807324
133P300_19829295_ChIP-Seq_ESCs_Human0.93745784
134RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93656537
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92915082
136GATA3_21867929_ChIP-Seq_CD8_Mouse0.92282373
137LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92268764
138TP53_23651856_ChIP-Seq_MEFs_Mouse0.91949403
139IRF8_27001747_Chip-Seq_BMDM_Mouse0.91505286
140BCOR_27268052_Chip-Seq_Bcells_Human0.90926086
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.90912702
142EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90846177
143RAC3_21632823_ChIP-Seq_H3396_Human0.90254986
144SPI1_20517297_ChIP-Seq_HL60_Human0.90182690
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89655149
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89243535
147SOX9_26525672_Chip-Seq_HEART_Mouse0.88962194
148VDR_21846776_ChIP-Seq_THP-1_Human0.88763469
149SMC4_20622854_ChIP-Seq_HELA_Human0.88762125
150EZH2_27304074_Chip-Seq_ESCs_Mouse0.88509724
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.88007495
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87279808
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.87256493
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87165440
155NFYB_21822215_ChIP-Seq_K562_Human0.87122794
156STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.87114818
157* TP63_22573176_ChIP-Seq_HFKS_Human0.86585843
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86410817
159TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86364734
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.86304085
161SMAD4_21741376_ChIP-Seq_EPCs_Human0.86075028
162STAT3_23295773_ChIP-Seq_U87_Human0.86050833
163OCT4_20526341_ChIP-Seq_ESCs_Human0.85904244
164NFYA_21822215_ChIP-Seq_K562_Human0.85709700
165GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85060810
166SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84934341
167FOXA2_19822575_ChIP-Seq_HepG2_Human0.84732142
168TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84436544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration4.61353955
2MP0000751_myopathy4.46412184
3MP0004036_abnormal_muscle_relaxation4.31961317
4MP0002837_dystrophic_cardiac_calcinosis4.29345865
5MP0004084_abnormal_cardiac_muscle4.22123535
6MP0004145_abnormal_muscle_electrophysio3.88233487
7MP0003646_muscle_fatigue3.80161672
8MP0005330_cardiomyopathy3.24169474
9MP0004215_abnormal_myocardial_fiber3.12731121
10MP0003950_abnormal_plasma_membrane3.04552752
11MP0000747_muscle_weakness2.83639720
12* MP0004087_abnormal_muscle_fiber2.82577333
13MP0000920_abnormal_myelination2.80020209
14MP0004510_myositis2.73378671
15MP0002106_abnormal_muscle_physiology2.65877433
16MP0005620_abnormal_muscle_contractility2.46717309
17MP0002972_abnormal_cardiac_muscle2.39202740
18MP0002269_muscular_atrophy2.32991053
19MP0003137_abnormal_impulse_conducting2.22858465
20MP0005369_muscle_phenotype2.12341978
21* MP0000759_abnormal_skeletal_muscle2.07483402
22MP0010630_abnormal_cardiac_muscle2.03085312
23MP0008775_abnormal_heart_ventricle1.95841636
24MP0001790_abnormal_immune_system1.95149803
25MP0005387_immune_system_phenotype1.95149803
26MP0003690_abnormal_glial_cell1.88780748
27MP0001800_abnormal_humoral_immune1.85187093
28MP0000750_abnormal_muscle_regeneration1.83207398
29MP0004484_altered_response_of1.72737039
30MP0005385_cardiovascular_system_phenoty1.65312636
31MP0001544_abnormal_cardiovascular_syste1.65312636
32MP0004130_abnormal_muscle_cell1.63667013
33MP0004085_abnormal_heartbeat1.61638105
34MP0001835_abnormal_antigen_presentation1.58479956
35MP0003828_pulmonary_edema1.53549303
36MP0006138_congestive_heart_failure1.49050249
37MP0001529_abnormal_vocalization1.43723858
38MP0006036_abnormal_mitochondrial_physio1.38124525
39MP0005451_abnormal_body_composition1.37666920
40MP0003221_abnormal_cardiomyocyte_apopto1.36431099
41MP0004233_abnormal_muscle_weight1.32812109
42MP0000733_abnormal_muscle_development1.28136380
43MP0002127_abnormal_cardiovascular_syste1.21180441
44MP0002332_abnormal_exercise_endurance1.20723494
45MP0003880_abnormal_central_pattern1.20266630
46MP0002452_abnormal_antigen_presenting1.12562356
47MP0001986_abnormal_taste_sensitivity1.11014521
48MP0002272_abnormal_nervous_system1.10917355
49MP0004134_abnormal_chest_morphology1.05196263
50MP0000013_abnormal_adipose_tissue1.02382130
51MP0004270_analgesia1.02304004
52MP0004142_abnormal_muscle_tone1.01682541
53MP0004147_increased_porphyrin_level1.01515970
54MP0008569_lethality_at_weaning0.99400010
55MP0001905_abnormal_dopamine_level0.98055375
56MP0005171_absent_coat_pigmentation0.96948100
57MP0002064_seizures0.96132886
58MP0003634_abnormal_glial_cell0.95073992
59MP0000685_abnormal_immune_system0.94462327
60MP0004742_abnormal_vestibular_system0.94219543
61MP0004043_abnormal_pH_regulation0.93352400
62MP0005423_abnormal_somatic_nervous0.93154377
63MP0005000_abnormal_immune_tolerance0.90852681
64MP0001486_abnormal_startle_reflex0.90595321
65MP0003136_yellow_coat_color0.90267308
66MP0003806_abnormal_nucleotide_metabolis0.88331114
67MP0002971_abnormal_brown_adipose0.85598473
68MP0003879_abnormal_hair_cell0.84764044
69MP0002638_abnormal_pupillary_reflex0.82773424
70MP0005310_abnormal_salivary_gland0.82042629
71MP0002723_abnormal_immune_serum0.81384286
72MP0004185_abnormal_adipocyte_glucose0.81244142
73MP0002933_joint_inflammation0.81081178
74MP0002108_abnormal_muscle_morphology0.80865688
75MP0000266_abnormal_heart_morphology0.78638657
76MP0009046_muscle_twitch0.78509524
77MP0002822_catalepsy0.78432132
78MP0002420_abnormal_adaptive_immunity0.78352704
79MP0002229_neurodegeneration0.77866572
80MP0005623_abnormal_meninges_morphology0.76606850
81MP0009780_abnormal_chondrocyte_physiolo0.76355703
82MP0005551_abnormal_eye_electrophysiolog0.74551442
83MP0003303_peritoneal_inflammation0.74273531
84MP0000372_irregular_coat_pigmentation0.74173618
85MP0003172_abnormal_lysosome_physiology0.72744384
86MP0000003_abnormal_adipose_tissue0.69979764
87MP0002734_abnormal_mechanical_nocicepti0.69553792
88MP0001819_abnormal_immune_cell0.69542871
89MP0002234_abnormal_pharynx_morphology0.69443236
90MP0006035_abnormal_mitochondrial_morpho0.68824900
91MP0002067_abnormal_sensory_capabilities0.67399919
92MP0009745_abnormal_behavioral_response0.66877940
93MP0005375_adipose_tissue_phenotype0.66277817
94MP0001440_abnormal_grooming_behavior0.63871892
95MP0005666_abnormal_adipose_tissue0.63844179
96MP0004924_abnormal_behavior0.63536340
97MP0005386_behavior/neurological_phenoty0.63536340
98MP0005670_abnormal_white_adipose0.63120820
99MP0006276_abnormal_autonomic_nervous0.62291951
100MP0005671_abnormal_response_to0.61423156
101MP0005083_abnormal_biliary_tract0.61154377
102MP0003045_fibrosis0.61047427
103MP0000716_abnormal_immune_system0.60965984
104MP0001485_abnormal_pinna_reflex0.60759832
105MP0006072_abnormal_retinal_apoptosis0.60299920
106MP0001502_abnormal_circadian_rhythm0.59632024
107MP0000689_abnormal_spleen_morphology0.59238495
108MP0008874_decreased_physiological_sensi0.59149086
109MP0005167_abnormal_blood-brain_barrier0.58599246
110MP0004885_abnormal_endolymph0.58584983
111MP0005409_darkened_coat_color0.58163285
112MP0001661_extended_life_span0.54771338
113MP0003632_abnormal_nervous_system0.54670804
114MP0005266_abnormal_metabolism0.54617532
115MP0002398_abnormal_bone_marrow0.54001795
116MP0001968_abnormal_touch/_nociception0.52855131
117MP0002066_abnormal_motor_capabilities/c0.52422553
118MP0003635_abnormal_synaptic_transmissio0.52283614
119MP0001299_abnormal_eye_distance/0.49142866
120MP0002078_abnormal_glucose_homeostasis0.47482465
121MP0005332_abnormal_amino_acid0.46518568
122MP0000230_abnormal_systemic_arterial0.45869519
123MP0002249_abnormal_larynx_morphology0.41698504
124MP0008872_abnormal_physiological_respon0.40031093
125MP0005535_abnormal_body_temperature0.39523112
126MP0005452_abnormal_adipose_tissue0.36416349
127MP0008875_abnormal_xenobiotic_pharmacok0.33202478
128MP0002114_abnormal_axial_skeleton0.32929547
129MP0005584_abnormal_enzyme/coenzyme_acti0.32813233
130MP0001943_abnormal_respiration0.31946200
131MP0002735_abnormal_chemical_nociception0.31667010
132MP0001346_abnormal_lacrimal_gland0.31650033
133MP0005376_homeostasis/metabolism_phenot0.28191880
134MP0003948_abnormal_gas_homeostasis0.27837524
135MP0009250_abnormal_appendicular_skeleto0.27577302
136MP0001984_abnormal_olfaction0.27145361
137MP0005253_abnormal_eye_physiology0.26935680
138MP0001970_abnormal_pain_threshold0.26847947

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.11151739
2Gastrointestinal stroma tumor (HP:0100723)6.08170897
3Muscle hypertrophy of the lower extremities (HP:0008968)5.95792955
4Calf muscle hypertrophy (HP:0008981)5.87108287
5Ulnar deviation of the wrist (HP:0003049)5.66200461
6Sudden death (HP:0001699)5.58506998
7Exercise-induced muscle cramps (HP:0003710)5.46742421
8Muscle fiber inclusion bodies (HP:0100299)4.93408206
9Calcaneovalgus deformity (HP:0001848)4.86484667
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.80654993
11Hyporeflexia of lower limbs (HP:0002600)4.78309760
12Agammaglobulinemia (HP:0004432)4.73108943
13Abnormality of the calf musculature (HP:0001430)4.60676607
14Muscle fiber splitting (HP:0003555)4.57897347
15Nemaline bodies (HP:0003798)4.49234187
16EMG: myopathic abnormalities (HP:0003458)4.44680029
17Deformed tarsal bones (HP:0008119)4.39260267
18Subaortic stenosis (HP:0001682)4.37588120
19Abnormality of the left ventricular outflow tract (HP:0011103)4.37588120
20Absent phalangeal crease (HP:0006109)4.34497419
21Fetal akinesia sequence (HP:0001989)4.28434995
22Ventricular tachycardia (HP:0004756)4.21196459
23Type 1 muscle fiber predominance (HP:0003803)4.12864156
24Popliteal pterygium (HP:0009756)3.75636831
25Atrial fibrillation (HP:0005110)3.66267822
26Abnormal finger flexion creases (HP:0006143)3.59789301
27Centrally nucleated skeletal muscle fibers (HP:0003687)3.56111774
28Round ear (HP:0100830)3.54922717
29Myoglobinuria (HP:0002913)3.52506063
30Difficulty running (HP:0009046)3.49675029
31Lipoatrophy (HP:0100578)3.39180207
32Degeneration of the lateral corticospinal tracts (HP:0002314)3.32120202
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.32120202
34Primary atrial arrhythmia (HP:0001692)3.30981885
35Fatigable weakness (HP:0003473)3.19568845
36Abnormality of the neuromuscular junction (HP:0003398)3.19568845
37Supraventricular tachycardia (HP:0004755)3.14766325
38Supraventricular arrhythmia (HP:0005115)3.04913024
39Frequent falls (HP:0002359)3.04863003
40Recurrent sinusitis (HP:0011108)3.04583783
41Small epiphyses (HP:0010585)3.04307145
42Distal lower limb muscle weakness (HP:0009053)3.02238873
43Weak cry (HP:0001612)3.02144831
44Type 2 muscle fiber atrophy (HP:0003554)3.00043588
45Areflexia of lower limbs (HP:0002522)2.99414270
46Prolonged QT interval (HP:0001657)2.99286317
47Sensory axonal neuropathy (HP:0003390)2.98077129
48Dilated cardiomyopathy (HP:0001644)2.94746796
49Distal arthrogryposis (HP:0005684)2.93428998
50Rhabdomyolysis (HP:0003201)2.91400863
51Neck muscle weakness (HP:0000467)2.90013104
52Verrucae (HP:0200043)2.88969802
53Papilloma (HP:0012740)2.88969802
54Amniotic constriction ring (HP:0009775)2.82550135
55Abnormality of placental membranes (HP:0011409)2.82550135
56Scapular winging (HP:0003691)2.78858542
57Asymmetric septal hypertrophy (HP:0001670)2.78291643
58Syncope (HP:0001279)2.71910966
59Bulbar palsy (HP:0001283)2.70600581
60Abnormality of the calcaneus (HP:0008364)2.69490621
61Muscle fiber atrophy (HP:0100295)2.66448515
62Emphysema (HP:0002097)2.61607302
63Muscle stiffness (HP:0003552)2.60472510
64Myopathic facies (HP:0002058)2.60242399
65Hip contracture (HP:0003273)2.55303472
66Myotonia (HP:0002486)2.54028631
67Ventricular arrhythmia (HP:0004308)2.52392855
68Cellulitis (HP:0100658)2.51171575
69Aplasia of the musculature (HP:0100854)2.50051086
70Gowers sign (HP:0003391)2.49094572
71Recurrent bronchitis (HP:0002837)2.47803735
72Abnormality of glycolysis (HP:0004366)2.44040840
73Increased serum pyruvate (HP:0003542)2.44040840
74Mildly elevated creatine phosphokinase (HP:0008180)2.44024509
75Rimmed vacuoles (HP:0003805)2.43674447
76Pheochromocytoma (HP:0002666)2.42873402
77Neuroendocrine neoplasm (HP:0100634)2.38354529
78Increased variability in muscle fiber diameter (HP:0003557)2.36227713
79Restrictive lung disease (HP:0002091)2.35885875
80Abnormality of skeletal muscle fiber size (HP:0012084)2.35745074
81Acute necrotizing encephalopathy (HP:0006965)2.31687484
82Lymphopenia (HP:0001888)2.25351334
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.24399249
84Hypoplastic ischia (HP:0003175)2.22405980
85Colitis (HP:0002583)2.22045346
86Increased connective tissue (HP:0009025)2.21382341
87Abnormality of the foot musculature (HP:0001436)2.20863633
88Facial diplegia (HP:0001349)2.19693770
89Limb-girdle muscle atrophy (HP:0003797)2.17995446
90Abnormal mitochondria in muscle tissue (HP:0008316)2.15340808
91Metatarsus adductus (HP:0001840)2.14060118
92Bundle branch block (HP:0011710)2.12753254
93Abnormality of the corticospinal tract (HP:0002492)2.10475196
94Left ventricular hypertrophy (HP:0001712)2.09234793
95Heart block (HP:0012722)2.09211577
96Hyperkalemia (HP:0002153)2.08425953
97Generalized muscle weakness (HP:0003324)2.07450456
98Abnormality of cells of the lymphoid lineage (HP:0012140)2.07237139
99Long clavicles (HP:0000890)2.07070646
100Foot dorsiflexor weakness (HP:0009027)2.06701466
101Mitochondrial inheritance (HP:0001427)2.04126376
102Chronic sinusitis (HP:0011109)2.03962364
103Premature skin wrinkling (HP:0100678)2.02542413
104Cerebral hemorrhage (HP:0001342)2.01941869
105Progressive macrocephaly (HP:0004481)2.00834358
106Abnormal EKG (HP:0003115)1.99474727
107Respiratory insufficiency due to muscle weakness (HP:0002747)1.97831161
108Steppage gait (HP:0003376)1.97396137
109Atrioventricular block (HP:0001678)1.96876446
110Recurrent pneumonia (HP:0006532)1.96413319
111Palpitations (HP:0001962)1.96038656
112Double outlet right ventricle (HP:0001719)1.95907971
113Congenital malformation of the right heart (HP:0011723)1.95907971
114Distal lower limb amyotrophy (HP:0008944)1.94305562
115Leukodystrophy (HP:0002415)1.93435088
116Slender build (HP:0001533)1.92974670
117Muscular dystrophy (HP:0003560)1.92898358
118Nonprogressive disorder (HP:0003680)1.92429921
119Akinesia (HP:0002304)1.91288336
120Progressive muscle weakness (HP:0003323)1.90472238
121EMG: neuropathic changes (HP:0003445)1.89269928
122Abnormality of the shoulder girdle musculature (HP:0001435)1.88727975
123Proximal amyotrophy (HP:0007126)1.88168054
124Easy fatigability (HP:0003388)1.87859589
125Increased CSF lactate (HP:0002490)1.86789527
126Abnormality of the ischium (HP:0003174)1.86330055
127Hepatocellular necrosis (HP:0001404)1.85801414
128Recurrent lower respiratory tract infections (HP:0002783)1.84629198
129Peripheral hypomyelination (HP:0007182)1.84067889
130Waddling gait (HP:0002515)1.83499668
131Abnormal atrioventricular conduction (HP:0005150)1.82696300
132Abnormality of the tricuspid valve (HP:0001702)1.82217427
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80545300
134Absent epiphyses (HP:0010577)1.80545300
135Breech presentation (HP:0001623)1.79694497
136IgA deficiency (HP:0002720)1.79301044
137Malignant hyperthermia (HP:0002047)1.76971460
138Atonic seizures (HP:0010819)1.76600887
139Difficulty climbing stairs (HP:0003551)1.75930757
140Spinal rigidity (HP:0003306)1.70438611
141Limited hip movement (HP:0008800)1.70084106
142Thin ribs (HP:0000883)1.63483127
143Ulnar deviation of finger (HP:0009465)1.61009552
144Exercise intolerance (HP:0003546)1.58707218
145Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.53421523
146Aplasia/Hypoplasia involving the musculature (HP:0001460)1.50275440
147Lower limb amyotrophy (HP:0007210)1.46615136
148Pterygium (HP:0001059)1.44343814
149Symphalangism affecting the phalanges of the hand (HP:0009773)1.42279146
150Adducted thumb (HP:0001181)1.41991645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.44436664
2STK393.73255242
3MAP4K13.48363987
4TTN3.38662463
5PHKG22.94076975
6PHKG12.94076975
7PKN12.61662177
8TNIK2.48503680
9PINK12.47088553
10EPHB12.34871265
11OXSR12.12532936
12MAPKAPK32.05153038
13CSF1R1.89872054
14PRPF4B1.88161397
15DMPK1.83484987
16PIK3CA1.79730884
17FES1.77929682
18MYLK1.73958903
19PRKCQ1.67653174
20MUSK1.67209600
21CLK11.61041650
22WNK11.51109169
23CDC42BPA1.49947718
24MAP3K131.49571536
25PRKCH1.43944303
26ROCK21.39812887
27PIK3CG1.37237221
28MAP2K61.32504773
29MAPK121.30721574
30SYK1.26103332
31PRKD11.22188281
32BLK1.19537643
33UHMK11.19503457
34BTK1.19022133
35MARK11.17580565
36WNK41.15986463
37CSK1.13971997
38CCNB11.13652845
39EEF2K1.13020972
40ICK1.10198895
41PBK1.09910154
42PAK31.08412606
43STK241.05684119
44ROCK11.04874131
45LYN1.03129429
46CAMK2D1.02985925
47BCR1.02422567
48NME11.01248081
49FRK0.99299890
50TYRO30.99038251
51FGFR20.97266079
52MAP3K100.91869218
53CAMK2G0.89702826
54MAP2K40.89247572
55BRD40.88901643
56MOS0.87280507
57PRKAA10.87078287
58MAP3K70.86077335
59MAPK150.84613474
60STK40.84472936
61DAPK20.81444398
62MAPK70.81189117
63BCKDK0.80375907
64IRAK40.78714828
65GRK70.75809899
66LIMK10.74026086
67PDK10.73525025
68IRAK20.73038833
69INSRR0.72676904
70ITK0.69500693
71PDPK10.68263090
72FGR0.67939369
73CSNK1G30.67889524
74CSNK1A1L0.67347786
75FYN0.64266718
76MAPK130.63882898
77MST40.62941947
78GRK60.62043224
79CAMK10.61979364
80LMTK20.61646980
81TRIB30.60711525
82MAPK110.60187134
83TIE10.59858248
84MAP2K10.58816918
85TLK10.58628606
86PRKG10.58100093
87NEK60.57752141
88HCK0.57513038
89AKT20.57140545
90MAP4K20.57067632
91STK100.56934074
92INSR0.56661568
93CAMK40.56013259
94SGK2230.55621253
95SGK4940.55621253
96PRKCE0.55014912
97DYRK1B0.54396216
98NEK10.53132606
99EPHA40.52798323
100GRK10.50820334
101TNK20.49389312
102MARK30.49180821
103JAK10.49127038
104LRRK20.47272932
105CAMK2B0.47176255
106PAK60.46572635
107CSNK1D0.46098240
108IRAK10.45992097
109NEK90.45557943
110ERN10.44835478
111RIPK40.44208668
112PRKAA20.43993300
113PRKD20.43897804
114LCK0.43689240
115PKN20.43643213
116ERBB30.43544455
117ZAK0.43327262
118ADRBK20.43289651
119CSNK1G10.43096482
120MARK20.42595836
121MET0.40748240
122PDK20.40597198
123CAMK2A0.40361398
124PRKACB0.40240499
125PTK2B0.39586324
126SIK10.38504002
127PDK40.38241674
128PDK30.38241674
129PRKACA0.38074110
130TRPM70.37010783
131MAPK40.36941724
132MELK0.36516372
133ILK0.35475846
134PRKD30.34890353
135MAP2K30.34472050
136RPS6KA30.31861711
137SGK10.28681452
138STK110.24063982
139NTRK30.23500255
140MAPK100.21841315
141WNK30.21106459
142TBK10.19680561
143PRKACG0.18683239
144RPS6KA60.17791133
145MAPKAPK50.17263984
146BMPR1B0.17029974
147DAPK30.16936188
148RPS6KB10.16902016
149ADRBK10.15479544
150SIK20.15361721
151MAPK80.14886181
152RPS6KA10.14002817
153PRKCA0.11170185
154SGK30.10665190
155RPS6KL10.09453843
156RPS6KC10.09453843
157PRKCI0.09423994
158SGK20.08334374
159MAPK90.07578196

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.06725760
2B cell receptor signaling pathway_Homo sapiens_hsa046623.61377595
3Primary immunodeficiency_Homo sapiens_hsa053403.48784022
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.24510682
5Dilated cardiomyopathy_Homo sapiens_hsa054143.18069177
6Oxidative phosphorylation_Homo sapiens_hsa001903.16187501
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.03757641
8Parkinsons disease_Homo sapiens_hsa050122.91731578
9Circadian rhythm_Homo sapiens_hsa047102.66182334
10Fatty acid elongation_Homo sapiens_hsa000622.56070451
11Alzheimers disease_Homo sapiens_hsa050102.45423377
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18940571
13Arginine and proline metabolism_Homo sapiens_hsa003302.09806123
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98878975
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.90520099
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85102252
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81345162
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79567357
19Viral myocarditis_Homo sapiens_hsa054161.77533872
20Propanoate metabolism_Homo sapiens_hsa006401.73889792
21Nitrogen metabolism_Homo sapiens_hsa009101.71210620
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54340070
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53361654
24Fructose and mannose metabolism_Homo sapiens_hsa000511.53106156
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.52106441
26Ether lipid metabolism_Homo sapiens_hsa005651.50792278
27Huntingtons disease_Homo sapiens_hsa050161.46836910
28Arginine biosynthesis_Homo sapiens_hsa002201.45629610
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43997659
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42406567
31Oxytocin signaling pathway_Homo sapiens_hsa049211.29637744
32Hematopoietic cell lineage_Homo sapiens_hsa046401.28336688
33Phototransduction_Homo sapiens_hsa047441.24364021
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23045666
35Glutamatergic synapse_Homo sapiens_hsa047241.21278548
36Steroid biosynthesis_Homo sapiens_hsa001001.19237263
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14373489
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.10984097
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09176126
40Axon guidance_Homo sapiens_hsa043601.07348966
41Renal cell carcinoma_Homo sapiens_hsa052111.06669686
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05754771
43Carbon metabolism_Homo sapiens_hsa012001.01496833
44Fatty acid metabolism_Homo sapiens_hsa012120.99772204
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96165835
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95916706
47Tight junction_Homo sapiens_hsa045300.93727670
48Sulfur relay system_Homo sapiens_hsa041220.93280872
49Calcium signaling pathway_Homo sapiens_hsa040200.93121955
50Pentose phosphate pathway_Homo sapiens_hsa000300.92173702
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.90389231
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.89195262
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86938147
54Cholinergic synapse_Homo sapiens_hsa047250.86892044
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86789356
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.85135185
57Morphine addiction_Homo sapiens_hsa050320.84044013
58Platelet activation_Homo sapiens_hsa046110.84016943
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83523829
60Butanoate metabolism_Homo sapiens_hsa006500.82756880
61Amphetamine addiction_Homo sapiens_hsa050310.82035206
62Focal adhesion_Homo sapiens_hsa045100.81132472
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81062185
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80160417
65Gastric acid secretion_Homo sapiens_hsa049710.78620903
66Renin secretion_Homo sapiens_hsa049240.78538375
67Linoleic acid metabolism_Homo sapiens_hsa005910.78416091
68Phenylalanine metabolism_Homo sapiens_hsa003600.76902131
69Circadian entrainment_Homo sapiens_hsa047130.76824634
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76276550
71Fatty acid degradation_Homo sapiens_hsa000710.76229255
72T cell receptor signaling pathway_Homo sapiens_hsa046600.75954221
73GABAergic synapse_Homo sapiens_hsa047270.74824854
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73112194
75Tryptophan metabolism_Homo sapiens_hsa003800.72898143
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72796261
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71888591
78Non-homologous end-joining_Homo sapiens_hsa034500.71360164
79Biosynthesis of amino acids_Homo sapiens_hsa012300.71247999
80Pyruvate metabolism_Homo sapiens_hsa006200.68765662
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68133774
82ABC transporters_Homo sapiens_hsa020100.67775804
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67567192
84MAPK signaling pathway_Homo sapiens_hsa040100.66988000
85Long-term depression_Homo sapiens_hsa047300.66553408
86Insulin resistance_Homo sapiens_hsa049310.66544894
87beta-Alanine metabolism_Homo sapiens_hsa004100.66076401
88Serotonergic synapse_Homo sapiens_hsa047260.63816471
89Peroxisome_Homo sapiens_hsa041460.63493712
90Starch and sucrose metabolism_Homo sapiens_hsa005000.63034695
91Choline metabolism in cancer_Homo sapiens_hsa052310.61764875
92Lysine degradation_Homo sapiens_hsa003100.61743090
93Ovarian steroidogenesis_Homo sapiens_hsa049130.60112332
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.59765315
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59451301
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59280060
97GnRH signaling pathway_Homo sapiens_hsa049120.58263861
98Regulation of autophagy_Homo sapiens_hsa041400.57320875
99Salivary secretion_Homo sapiens_hsa049700.56720154
100Glucagon signaling pathway_Homo sapiens_hsa049220.55600999
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.54317056
102Type II diabetes mellitus_Homo sapiens_hsa049300.52756792
103Chemokine signaling pathway_Homo sapiens_hsa040620.51684125
104Osteoclast differentiation_Homo sapiens_hsa043800.51640043
105Endocytosis_Homo sapiens_hsa041440.50124571
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48877749
107Dopaminergic synapse_Homo sapiens_hsa047280.48812064
108Olfactory transduction_Homo sapiens_hsa047400.48675043
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47540018
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.47043081
111Pancreatic secretion_Homo sapiens_hsa049720.46600611
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45623875
113Taste transduction_Homo sapiens_hsa047420.43741223
114Histidine metabolism_Homo sapiens_hsa003400.40975242
115cAMP signaling pathway_Homo sapiens_hsa040240.39619033
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37571289
117Collecting duct acid secretion_Homo sapiens_hsa049660.37162356
118Insulin signaling pathway_Homo sapiens_hsa049100.36423783
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36119623
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34809298
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34646021
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32437888
123Insulin secretion_Homo sapiens_hsa049110.32432266
124Nicotine addiction_Homo sapiens_hsa050330.32237699
125AMPK signaling pathway_Homo sapiens_hsa041520.32004837
126Ras signaling pathway_Homo sapiens_hsa040140.29400071
127VEGF signaling pathway_Homo sapiens_hsa043700.29398754
128Proteoglycans in cancer_Homo sapiens_hsa052050.29370989
129Long-term potentiation_Homo sapiens_hsa047200.28977866
130PPAR signaling pathway_Homo sapiens_hsa033200.28805953
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28743872
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27985475
133ErbB signaling pathway_Homo sapiens_hsa040120.27203428
134ECM-receptor interaction_Homo sapiens_hsa045120.26986317
135Salmonella infection_Homo sapiens_hsa051320.26249200
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26153367
137HIF-1 signaling pathway_Homo sapiens_hsa040660.25654124
138Melanogenesis_Homo sapiens_hsa049160.25348180
139Purine metabolism_Homo sapiens_hsa002300.24726131
140Caffeine metabolism_Homo sapiens_hsa002320.24257817
141Metabolic pathways_Homo sapiens_hsa011000.23367776
142FoxO signaling pathway_Homo sapiens_hsa040680.23125678
143Inositol phosphate metabolism_Homo sapiens_hsa005620.22651708
144Sphingolipid metabolism_Homo sapiens_hsa006000.22474340
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.22014417

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