SRPRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.41119000
2Golgi transport vesicle coating (GO:0048200)6.41119000
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.05985229
4retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.87420619
5COPII vesicle coating (GO:0048208)3.70592517
6protein retention in ER lumen (GO:0006621)3.64230650
7negative regulation of erythrocyte differentiation (GO:0045647)3.61430553
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.47221445
9protein localization to endosome (GO:0036010)3.44152759
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.43102090
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36129910
12positive regulation of nuclease activity (GO:0032075)3.32425046
13vesicle coating (GO:0006901)3.30097851
14mannose metabolic process (GO:0006013)3.26481836
15endoplasmic reticulum unfolded protein response (GO:0030968)3.19256907
16skin morphogenesis (GO:0043589)3.14860919
17antigen processing and presentation of endogenous antigen (GO:0019883)3.14220365
18pinocytosis (GO:0006907)3.11940582
19ER-nucleus signaling pathway (GO:0006984)2.99625397
20cellular response to unfolded protein (GO:0034620)2.98940710
21regulation of nuclease activity (GO:0032069)2.98767363
22proline biosynthetic process (GO:0006561)2.88160371
23protein maturation by protein folding (GO:0022417)2.85065735
24regulation of histone H3-K27 methylation (GO:0061085)2.84970552
25regulation of cholesterol homeostasis (GO:2000188)2.80914650
26cellular response to topologically incorrect protein (GO:0035967)2.74274090
27regulation of early endosome to late endosome transport (GO:2000641)2.66603658
28embryonic process involved in female pregnancy (GO:0060136)2.65320069
29positive regulation of gamma-delta T cell activation (GO:0046645)2.59753113
30regulation of extracellular matrix disassembly (GO:0010715)2.59409064
31pentose-phosphate shunt (GO:0006098)2.58588102
32NIK/NF-kappaB signaling (GO:0038061)2.57619810
33stress fiber assembly (GO:0043149)2.55991169
34response to endoplasmic reticulum stress (GO:0034976)2.51187412
35regulation of glucose import in response to insulin stimulus (GO:2001273)2.49698081
36basement membrane organization (GO:0071711)2.49238464
37response to laminar fluid shear stress (GO:0034616)2.46938411
38cell-substrate junction assembly (GO:0007044)2.46696669
39hypotonic response (GO:0006971)2.44867348
40barbed-end actin filament capping (GO:0051016)2.44462491
41glucose 6-phosphate metabolic process (GO:0051156)2.43603692
42regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42894604
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41620815
44regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.39730802
45positive regulation of extracellular matrix organization (GO:1903055)2.39688256
46desmosome organization (GO:0002934)2.39243310
47maternal placenta development (GO:0001893)2.39020269
48negative regulation of cell size (GO:0045792)2.38916151
49hemidesmosome assembly (GO:0031581)2.38146716
50iron ion import (GO:0097286)2.36750425
51endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.35793722
52response to peptidoglycan (GO:0032494)2.34925482
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.34668785
54ER overload response (GO:0006983)2.33646121
55negative regulation of cell killing (GO:0031342)2.33429578
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33429578
57hyaluronan catabolic process (GO:0030214)2.32006075
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.31226381
59glucose catabolic process (GO:0006007)2.29947978
60positive regulation of Cdc42 GTPase activity (GO:0043089)2.28534155
61cellular response to interleukin-4 (GO:0071353)2.28292892
62positive regulation of blood vessel endothelial cell migration (GO:0043536)2.27230446
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.26703062
64NADH metabolic process (GO:0006734)2.26635452
65lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25456270
66response to muramyl dipeptide (GO:0032495)2.24765189
67modulation by symbiont of host cellular process (GO:0044068)2.24716630
68response to thyroid hormone (GO:0097066)2.24080474
69regulation of defense response to virus by virus (GO:0050690)2.22170167
70cell-substrate adherens junction assembly (GO:0007045)2.21281542
71focal adhesion assembly (GO:0048041)2.21281542
723-UTR-mediated mRNA stabilization (GO:0070935)2.20996174
73response to unfolded protein (GO:0006986)2.20288602
74protein carboxylation (GO:0018214)2.19784992
75peptidyl-glutamic acid carboxylation (GO:0017187)2.19784992
76membrane raft organization (GO:0031579)2.19061089
77peptidyl-proline hydroxylation (GO:0019511)2.18297028
78negative regulation of necroptotic process (GO:0060546)2.17763709
79activation of Rac GTPase activity (GO:0032863)2.17049923
80negative regulation of protein localization to plasma membrane (GO:1903077)2.16389115
81detection of bacterium (GO:0016045)2.15916106
82intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.15832878
83negative regulation of fatty acid biosynthetic process (GO:0045717)2.15454844
84glycosphingolipid catabolic process (GO:0046479)2.15422562
85protein hydroxylation (GO:0018126)2.14851666
86positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.13779159
87glycolipid catabolic process (GO:0019377)2.12652180
88cell adhesion mediated by integrin (GO:0033627)2.11749553
89regulation of gamma-delta T cell differentiation (GO:0045586)2.11467689
90oxaloacetate metabolic process (GO:0006107)2.10411234
91branching involved in mammary gland duct morphogenesis (GO:0060444)2.10283797
92regulation of necroptotic process (GO:0060544)2.10282408
93detection of other organism (GO:0098543)2.09944250
94negative regulation of fatty acid transport (GO:2000192)2.09927641
95NADPH regeneration (GO:0006740)2.09176687
96negative regulation of fibrinolysis (GO:0051918)2.08771465
97regulation of gamma-delta T cell activation (GO:0046643)2.08637779
98membrane protein ectodomain proteolysis (GO:0006509)2.07802540
99maintenance of protein localization in organelle (GO:0072595)2.07041310
100germinal center formation (GO:0002467)2.06915330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.27702675
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79124725
3MYC_22102868_ChIP-Seq_BL_Human2.57369730
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.57282160
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47278450
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.38366535
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28440730
8VDR_21846776_ChIP-Seq_THP-1_Human2.25830954
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06252064
10LXR_22292898_ChIP-Seq_THP-1_Human2.03263556
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98674314
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93664938
13RACK7_27058665_Chip-Seq_MCF-7_Human1.90473228
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89307418
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88780471
16CLOCK_20551151_ChIP-Seq_293T_Human1.88419005
17ZNF263_19887448_ChIP-Seq_K562_Human1.87971522
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82542666
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80235715
20TCF7_22412390_ChIP-Seq_EML_Mouse1.74996982
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.74664539
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71930651
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71491649
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69412523
25MAF_26560356_Chip-Seq_TH1_Human1.67897967
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64364247
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61252667
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58171172
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.56150067
30VDR_24763502_ChIP-Seq_THP-1_Human1.53341766
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.51623766
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51433294
33RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49665455
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47498990
35KDM2B_26808549_Chip-Seq_DND41_Human1.46727459
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45984971
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.44576965
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42506464
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41996260
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40425272
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.40206751
42NCOR1_26117541_ChIP-Seq_K562_Human1.40060225
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37264399
44ATF3_27146783_Chip-Seq_COLON_Human1.36842579
45UTX_26944678_Chip-Seq_JUKART_Human1.36659455
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34898963
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32786525
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32299796
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31968139
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31792925
51MAF_26560356_Chip-Seq_TH2_Human1.31388913
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30247905
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29551999
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26777193
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.25628603
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25368279
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24866647
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24057962
59ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21986179
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21890956
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21029734
62SPI1_23127762_ChIP-Seq_K562_Human1.20648554
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20513735
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19764991
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19090172
66TFEB_21752829_ChIP-Seq_HELA_Human1.17954842
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17181495
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14843523
69SPI1_23547873_ChIP-Seq_NB4_Human1.14435625
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14067767
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13378276
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12627215
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10756634
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08712253
75GATA1_19941826_ChIP-Seq_K562_Human1.08563040
76MYB_26560356_Chip-Seq_TH1_Human1.07614328
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07397606
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07130692
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06859650
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06809272
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.06644223
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04207639
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04053018
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.03669747
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03213762
86E2F7_22180533_ChIP-Seq_HELA_Human1.02562126
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02102147
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.00855881
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.00616932
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00589270
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00397546
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99769198
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99515699
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99515699
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.98560127
96ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98024600
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.97754769
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97588994
99IRF8_27001747_Chip-Seq_BMDM_Mouse0.96568710
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96331226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.23228293
2MP0003705_abnormal_hypodermis_morpholog3.12999775
3MP0005451_abnormal_body_composition2.89687938
4MP0005058_abnormal_lysosome_morphology2.78099212
5MP0003436_decreased_susceptibility_to2.77653194
6MP0003191_abnormal_cellular_cholesterol2.75770506
7MP0009840_abnormal_foam_cell2.74061608
8MP0003300_gastrointestinal_ulcer2.56586679
9MP0003566_abnormal_cell_adhesion2.36070635
10MP0002877_abnormal_melanocyte_morpholog1.94515450
11MP0010234_abnormal_vibrissa_follicle1.83385836
12MP0003303_peritoneal_inflammation1.83373372
13MP0004947_skin_inflammation1.82750232
14MP0008260_abnormal_autophagy1.82458150
15MP0003172_abnormal_lysosome_physiology1.73453022
16MP0000685_abnormal_immune_system1.67908896
17MP0005464_abnormal_platelet_physiology1.66804304
18MP0003763_abnormal_thymus_physiology1.65760108
19MP0000858_altered_metastatic_potential1.60631529
20MP0001835_abnormal_antigen_presentation1.51992069
21MP0004233_abnormal_muscle_weight1.50631471
22MP0001533_abnormal_skeleton_physiology1.49276765
23MP0002060_abnormal_skin_morphology1.48907751
24MP0003091_abnormal_cell_migration1.48817746
25MP0005000_abnormal_immune_tolerance1.48809854
26MP0005023_abnormal_wound_healing1.46777509
27MP0009333_abnormal_splenocyte_physiolog1.46513917
28MP0002139_abnormal_hepatobiliary_system1.45306953
29MP0005025_abnormal_response_to1.37298836
30MP0002419_abnormal_innate_immunity1.35569149
31MP0003453_abnormal_keratinocyte_physiol1.34428512
32MP0003279_aneurysm1.34257935
33MP0004264_abnormal_extraembryonic_tissu1.32116096
34MP0001790_abnormal_immune_system1.31153494
35MP0005387_immune_system_phenotype1.31153494
36MP0005076_abnormal_cell_differentiation1.28622802
37MP0004272_abnormal_basement_membrane1.27917979
38MP0010155_abnormal_intestine_physiology1.27496611
39MP0001958_emphysema1.27325789
40MP0005275_abnormal_skin_tensile1.27272212
41MP0003656_abnormal_erythrocyte_physiolo1.22527745
42MP0002796_impaired_skin_barrier1.22435077
43MP0001849_ear_inflammation1.21031249
44MP0010352_gastrointestinal_tract_polyps1.18496985
45MP0001873_stomach_inflammation1.16731462
46MP0005257_abnormal_intraocular_pressure1.16235849
47MP0009785_altered_susceptibility_to1.16017121
48MP0003724_increased_susceptibility_to1.12025646
49MP0004510_myositis1.11164205
50MP0002396_abnormal_hematopoietic_system1.10265689
51MP0001348_abnormal_lacrimal_gland1.09973243
52MP0002166_altered_tumor_susceptibility1.09842265
53MP0002452_abnormal_antigen_presenting1.09720760
54MP0001800_abnormal_humoral_immune1.09510251
55MP0005164_abnormal_response_to1.09446171
56MP0002998_abnormal_bone_remodeling1.09156511
57MP0002723_abnormal_immune_serum1.08483342
58MP0004782_abnormal_surfactant_physiolog1.07998842
59MP0004185_abnormal_adipocyte_glucose1.07152514
60MP0005409_darkened_coat_color1.05473451
61MP0001819_abnormal_immune_cell1.05206595
62MP0002420_abnormal_adaptive_immunity1.05071926
63MP0004858_abnormal_nervous_system1.04882859
64MP0002148_abnormal_hypersensitivity_rea1.04709242
65MP0001853_heart_inflammation1.03975970
66MP0003075_altered_response_to1.03092742
67MP0001216_abnormal_epidermal_layer1.01928602
68MP0002398_abnormal_bone_marrow1.00523053
69MP0002405_respiratory_system_inflammati1.00470959
70MP0005360_urolithiasis0.99361837
71MP0001845_abnormal_inflammatory_respons0.99031042
72MP0003045_fibrosis0.98138452
73MP0000003_abnormal_adipose_tissue0.97042593
74MP0003828_pulmonary_edema0.96801184
75MP0009278_abnormal_bone_marrow0.94226729
76MP0004808_abnormal_hematopoietic_stem0.93725289
77MP0005365_abnormal_bile_salt0.93513726
78MP0001851_eye_inflammation0.92068239
79MP0000678_abnormal_parathyroid_gland0.91891409
80MP0005621_abnormal_cell_physiology0.91367005
81MP0003868_abnormal_feces_composition0.90932633
82MP0008469_abnormal_protein_level0.90228212
83MP0009931_abnormal_skin_appearance0.90053148
84MP0000609_abnormal_liver_physiology0.89781840
85MP0001666_abnormal_nutrient_absorption0.88952447
86MP0003329_amyloid_beta_deposits0.88913702
87MP0005501_abnormal_skin_physiology0.88851054
88MP0000716_abnormal_immune_system0.86751052
89MP0002429_abnormal_blood_cell0.86711993
90MP0003795_abnormal_bone_structure0.86036866
91MP0005165_increased_susceptibility_to0.85846851
92MP0003448_altered_tumor_morphology0.85725360
93MP0000604_amyloidosis0.84877913
94MP0001243_abnormal_dermal_layer0.84097746
95MP0005390_skeleton_phenotype0.83958069
96MP0002722_abnormal_immune_system0.83786602
97MP0002896_abnormal_bone_mineralization0.78884275
98MP0005375_adipose_tissue_phenotype0.78221960
99MP0002006_tumorigenesis0.78128260
100MP0001881_abnormal_mammary_gland0.77348063

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.73369860
2Protrusio acetabuli (HP:0003179)3.56548034
3Vertebral compression fractures (HP:0002953)3.46566890
4Deep venous thrombosis (HP:0002625)2.66457588
5Dysostosis multiplex (HP:0000943)2.56317331
6Abnormal gallbladder physiology (HP:0012438)2.43763036
7Cholecystitis (HP:0001082)2.43763036
8Increased connective tissue (HP:0009025)2.38305363
9Eczematoid dermatitis (HP:0000976)2.36044328
10Cervical subluxation (HP:0003308)2.33790027
11Fragile skin (HP:0001030)2.33339327
12Distal lower limb amyotrophy (HP:0008944)2.24236094
13Blue sclerae (HP:0000592)2.23596182
14Upper limb amyotrophy (HP:0009129)2.23418209
15Distal upper limb amyotrophy (HP:0007149)2.23418209
16Cerebral aneurysm (HP:0004944)2.22889984
17Increased variability in muscle fiber diameter (HP:0003557)2.22303974
18Abnormality of skeletal muscle fiber size (HP:0012084)2.18659611
19Dilatation of the ascending aorta (HP:0005111)2.18617995
20Urinary glycosaminoglycan excretion (HP:0003541)2.18528039
21Mucopolysacchariduria (HP:0008155)2.18528039
22Abnormality of the Achilles tendon (HP:0005109)2.17452927
23Osteolytic defects of the hand bones (HP:0009699)2.16178471
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.16178471
25Interstitial pulmonary disease (HP:0006530)2.15429820
26Distal lower limb muscle weakness (HP:0009053)2.15186231
27Abnormality of macrophages (HP:0004311)2.14835081
28Achilles tendon contracture (HP:0001771)2.13544089
29Thin bony cortex (HP:0002753)2.13227167
30Abnormality of liposaccharide metabolism (HP:0010968)2.08885930
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.08885930
32Abnormality of glycolipid metabolism (HP:0010969)2.08885930
33Aneurysm (HP:0002617)2.08247021
34Broad face (HP:0000283)2.06861096
35Atrophic scars (HP:0001075)2.06658869
36Menorrhagia (HP:0000132)2.06389188
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.04659799
38Hyperacusis (HP:0010780)2.04551574
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.04492184
40Abnormality of polysaccharide metabolism (HP:0011012)2.04492184
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.04492184
42Polycythemia (HP:0001901)2.02677896
43Hemorrhage of the eye (HP:0011885)2.00758072
44J-shaped sella turcica (HP:0002680)1.98611479
45Myocardial infarction (HP:0001658)1.98111188
46Hypertensive crisis (HP:0100735)1.97588089
47Increased IgE level (HP:0003212)1.97566794
48Spinal rigidity (HP:0003306)1.97263308
49Ankle contracture (HP:0006466)1.96995836
50Fatigue (HP:0012378)1.96840429
51Wormian bones (HP:0002645)1.96706926
52Flat acetabular roof (HP:0003180)1.96164576
53Back pain (HP:0003418)1.94959443
54Spondylolisthesis (HP:0003302)1.94131584
55Abnormality of the distal phalanges of the toes (HP:0010182)1.94008125
56Loss of speech (HP:0002371)1.92505829
57Abnormality of complement system (HP:0005339)1.91220126
58Cellulitis (HP:0100658)1.90927362
59Hand muscle atrophy (HP:0009130)1.88064658
60Mitral stenosis (HP:0001718)1.87771216
61Aortic dissection (HP:0002647)1.86606532
62Abnormality of oral frenula (HP:0000190)1.85679184
63Aortic aneurysm (HP:0004942)1.84100242
64Ankyloglossia (HP:0010296)1.83062249
65Disproportionate tall stature (HP:0001519)1.82715522
66Vascular tortuosity (HP:0004948)1.82332882
67Short nail (HP:0001799)1.82017723
68Emphysema (HP:0002097)1.81297066
69Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81044601
70Abnormality of the common coagulation pathway (HP:0010990)1.80941119
71Biconcave vertebral bodies (HP:0004586)1.80119086
72Epistaxis (HP:0000421)1.79950735
73Purpura (HP:0000979)1.79585840
74Arterial tortuosity (HP:0005116)1.78897532
75Gingival bleeding (HP:0000225)1.78859998
76Systemic lupus erythematosus (HP:0002725)1.75584741
77Nonimmune hydrops fetalis (HP:0001790)1.72711285
78Peritonitis (HP:0002586)1.72362688
79Cardiovascular calcification (HP:0011915)1.70728273
80Impaired platelet aggregation (HP:0003540)1.70133208
81Abnormal platelet function (HP:0011869)1.70133208
82Gastrointestinal stroma tumor (HP:0100723)1.69400100
83Increased serum ferritin (HP:0003281)1.69038619
84Exercise-induced myalgia (HP:0003738)1.69007954
85Xanthomatosis (HP:0000991)1.68051250
86Petechiae (HP:0000967)1.68028758
87Trismus (HP:0000211)1.67393342
88Vacuolated lymphocytes (HP:0001922)1.66642631
89Long palpebral fissure (HP:0000637)1.66007643
90Reticulocytosis (HP:0001923)1.65375844
91Asymmetric septal hypertrophy (HP:0001670)1.64395427
92Bladder diverticulum (HP:0000015)1.64290151
93Elbow flexion contracture (HP:0002987)1.62873468
94Bone pain (HP:0002653)1.62540008
95Mildly elevated creatine phosphokinase (HP:0008180)1.61930448
96Abnormality of the acetabulum (HP:0003170)1.61428734
97Vascular calcification (HP:0004934)1.60577447
98Orthostatic hypotension (HP:0001278)1.60258295
99Mitral regurgitation (HP:0001653)1.59954697
100Sparse lateral eyebrow (HP:0005338)1.59583724

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.50127305
2TRIB33.81266758
3PRPF4B3.11275534
4IRAK32.79952505
5SIK12.48651904
6SMG12.46171340
7EEF2K2.08507899
8CDK122.04183001
9ICK2.01171531
10FGFR41.96994593
11EPHA21.91678227
12EPHB11.73232688
13MAP2K31.65053145
14RIPK41.58399018
15MAP3K131.58140999
16MST1R1.56676004
17MAP4K11.55949379
18MAP3K141.54582298
19NME21.53548851
20TYK21.53020659
21PAK41.48185088
22ZAP701.47463825
23TBK11.47291230
24TESK11.45833596
25PKN21.41944901
26TESK21.41752491
27MAP3K31.40296621
28SCYL21.38410506
29TTN1.36572175
30PDGFRA1.36312486
31RIPK11.33163168
32TAOK21.30481243
33IRAK41.23863541
34KSR21.22404841
35LMTK21.21337325
36ARAF1.19858109
37MAPKAPK31.10437061
38SIK31.10265266
39PRKD21.08898653
40MAP3K11.04293988
41EIF2AK11.02486248
42JAK31.02151195
43JAK11.00342783
44PTK20.98093963
45TRPM70.93675600
46CDC42BPA0.91278968
47MTOR0.89659102
48MAPK110.89586794
49PDPK10.84780100
50PTK60.83776702
51PIM20.82152756
52LRRK20.78205132
53GRK60.75750164
54HIPK20.74053490
55NEK90.71423992
56MAP3K110.71150738
57STK100.68674131
58MAP3K80.67564255
59MYLK0.67198930
60FGFR30.65880571
61TGFBR20.65826602
62CSK0.63642263
63MAP3K20.63097806
64BTK0.62960745
65BMX0.61885059
66ILK0.61766493
67MOS0.58153010
68TAOK10.55991731
69MARK20.55939134
70RPS6KB20.55053169
71PDK10.54194805
72HCK0.53574349
73MAPKAPK20.53199316
74IKBKE0.52519659
75IRAK20.50399791
76CDK40.49931121
77RET0.49771291
78CLK10.48980603
79CDK90.48903604
80MAP3K60.48600335
81PIK3CG0.48007148
82MET0.47673958
83JAK20.47256220
84RAF10.46783264
85PAK20.46669000
86PRKG20.45769482
87BLK0.45241150
88DDR20.44731218
89RPS6KA20.44107626
90CSF1R0.42501876
91PDGFRB0.41869104
92MAPK120.41826768
93MAP2K20.41663558
94IRAK10.40844981
95STK380.40436959
96CDK60.39933654
97IKBKB0.37728728
98NTRK10.37296747
99CDK70.35443621
100MAP3K100.34977430

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.36010308
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.40004391
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.12178786
4Acute myeloid leukemia_Homo sapiens_hsa052212.08413349
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.05866699
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.98703980
7Chronic myeloid leukemia_Homo sapiens_hsa052201.84788762
8Pentose phosphate pathway_Homo sapiens_hsa000301.63222157
9B cell receptor signaling pathway_Homo sapiens_hsa046621.58865879
10Pancreatic cancer_Homo sapiens_hsa052121.55575494
11Fructose and mannose metabolism_Homo sapiens_hsa000511.50599086
12Non-small cell lung cancer_Homo sapiens_hsa052231.50449146
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48996440
14Osteoclast differentiation_Homo sapiens_hsa043801.40718683
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36539899
16Influenza A_Homo sapiens_hsa051641.36484364
17Prion diseases_Homo sapiens_hsa050201.34631971
18Lysosome_Homo sapiens_hsa041421.34433003
19Galactose metabolism_Homo sapiens_hsa000521.33682816
20VEGF signaling pathway_Homo sapiens_hsa043701.32481538
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32168240
22Leishmaniasis_Homo sapiens_hsa051401.31621829
23Toxoplasmosis_Homo sapiens_hsa051451.31255456
24Bladder cancer_Homo sapiens_hsa052191.30877373
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.30770093
26N-Glycan biosynthesis_Homo sapiens_hsa005101.26320596
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26080825
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26072448
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.23493973
30Measles_Homo sapiens_hsa051621.22612213
31Hepatitis B_Homo sapiens_hsa051611.22531038
32Hepatitis C_Homo sapiens_hsa051601.22381239
33Complement and coagulation cascades_Homo sapiens_hsa046101.20973094
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.18016431
35Thyroid cancer_Homo sapiens_hsa052161.17317559
36TNF signaling pathway_Homo sapiens_hsa046681.16643790
37Shigellosis_Homo sapiens_hsa051311.14716586
38Apoptosis_Homo sapiens_hsa042101.11950844
39Renal cell carcinoma_Homo sapiens_hsa052111.11391394
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08982433
41Amoebiasis_Homo sapiens_hsa051461.08544660
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.04786631
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04060356
44Small cell lung cancer_Homo sapiens_hsa052221.02857045
45Focal adhesion_Homo sapiens_hsa045101.01894690
46Vibrio cholerae infection_Homo sapiens_hsa051101.00850428
47Insulin resistance_Homo sapiens_hsa049310.97872173
48Biosynthesis of amino acids_Homo sapiens_hsa012300.97016376
49Herpes simplex infection_Homo sapiens_hsa051680.95286762
50Tuberculosis_Homo sapiens_hsa051520.92297446
51T cell receptor signaling pathway_Homo sapiens_hsa046600.91555865
52Pertussis_Homo sapiens_hsa051330.87840311
53Malaria_Homo sapiens_hsa051440.86552037
54Viral myocarditis_Homo sapiens_hsa054160.86464469
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.86198881
56Carbon metabolism_Homo sapiens_hsa012000.86173344
57Insulin signaling pathway_Homo sapiens_hsa049100.86043891
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85959052
59Staphylococcus aureus infection_Homo sapiens_hsa051500.85852720
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.85224155
61Prostate cancer_Homo sapiens_hsa052150.84961623
62mTOR signaling pathway_Homo sapiens_hsa041500.84911323
63Endometrial cancer_Homo sapiens_hsa052130.84908002
64Prolactin signaling pathway_Homo sapiens_hsa049170.84254964
65Proteoglycans in cancer_Homo sapiens_hsa052050.83195792
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.81257086
67Endocytosis_Homo sapiens_hsa041440.80684419
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80133017
69Legionellosis_Homo sapiens_hsa051340.79825007
70Phenylalanine metabolism_Homo sapiens_hsa003600.79529230
71Notch signaling pathway_Homo sapiens_hsa043300.78207643
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76333875
73HIF-1 signaling pathway_Homo sapiens_hsa040660.72745538
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71721315
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70814875
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70803919
77ECM-receptor interaction_Homo sapiens_hsa045120.69985820
78Antigen processing and presentation_Homo sapiens_hsa046120.69368294
79Platelet activation_Homo sapiens_hsa046110.68505715
80Salmonella infection_Homo sapiens_hsa051320.68378665
81Viral carcinogenesis_Homo sapiens_hsa052030.67967711
82HTLV-I infection_Homo sapiens_hsa051660.67367070
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64819062
84Phagosome_Homo sapiens_hsa041450.64102817
85Allograft rejection_Homo sapiens_hsa053300.62365492
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59475398
87Glioma_Homo sapiens_hsa052140.57865396
88Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57106794
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56973800
90Primary immunodeficiency_Homo sapiens_hsa053400.55936743
91Epstein-Barr virus infection_Homo sapiens_hsa051690.55589887
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55512380
93Hematopoietic cell lineage_Homo sapiens_hsa046400.54522515
94Inositol phosphate metabolism_Homo sapiens_hsa005620.53445170
95Chemokine signaling pathway_Homo sapiens_hsa040620.52255825
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.52252793
97AMPK signaling pathway_Homo sapiens_hsa041520.51912605
98Autoimmune thyroid disease_Homo sapiens_hsa053200.51640280
99Arginine biosynthesis_Homo sapiens_hsa002200.51507520
100ErbB signaling pathway_Homo sapiens_hsa040120.50098838

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