SRPRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.39431491
2Golgi transport vesicle coating (GO:0048200)6.39431491
3signal peptide processing (GO:0006465)5.08738310
4lactate metabolic process (GO:0006089)4.93957445
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.91532321
6nucleobase biosynthetic process (GO:0046112)4.41279816
7protein retention in ER lumen (GO:0006621)4.40775903
8DNA deamination (GO:0045006)4.26818223
9formation of translation preinitiation complex (GO:0001731)4.22596162
10purine nucleobase biosynthetic process (GO:0009113)4.14367552
11protein maturation by protein folding (GO:0022417)4.04244934
12respiratory chain complex IV assembly (GO:0008535)3.98444902
13ER overload response (GO:0006983)3.97316191
14ribosomal small subunit assembly (GO:0000028)3.93845594
15DNA strand elongation involved in DNA replication (GO:0006271)3.88636467
16DNA strand elongation (GO:0022616)3.87007478
17folic acid-containing compound biosynthetic process (GO:0009396)3.76235032
18regulation of hexokinase activity (GO:1903299)3.70000905
19regulation of glucokinase activity (GO:0033131)3.70000905
20cytochrome complex assembly (GO:0017004)3.69759697
21cullin deneddylation (GO:0010388)3.68445531
22protein deneddylation (GO:0000338)3.67262144
23GDP-mannose metabolic process (GO:0019673)3.60744017
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59888211
25* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58218195
26L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.57764168
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.54870837
28termination of RNA polymerase III transcription (GO:0006386)3.54870837
29IMP biosynthetic process (GO:0006188)3.53433430
30telomere maintenance via semi-conservative replication (GO:0032201)3.51895124
31regulation of mitochondrial translation (GO:0070129)3.50861081
32water-soluble vitamin biosynthetic process (GO:0042364)3.49759674
33proteasome assembly (GO:0043248)3.46310054
34* cotranslational protein targeting to membrane (GO:0006613)3.46107818
35* protein targeting to ER (GO:0045047)3.45443510
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42815339
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41919208
38positive regulation of protein autophosphorylation (GO:0031954)3.41338845
39ribosome biogenesis (GO:0042254)3.40848964
40GMP metabolic process (GO:0046037)3.39773750
41regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.36384972
42maturation of SSU-rRNA (GO:0030490)3.36033535
43ribosome assembly (GO:0042255)3.35899860
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35789285
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.33146803
46regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.33088076
47* protein localization to endoplasmic reticulum (GO:0070972)3.29524563
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29018658
49negative regulation of ligase activity (GO:0051352)3.29018658
50platelet dense granule organization (GO:0060155)3.27452549
51* establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26092515
52peptidyl-histidine modification (GO:0018202)3.26043522
53nucleotide-sugar biosynthetic process (GO:0009226)3.25404311
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25333688
55protein complex biogenesis (GO:0070271)3.24971851
56DNA replication initiation (GO:0006270)3.23428227
57zinc ion transport (GO:0006829)3.21456280
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.20583974
59branched-chain amino acid catabolic process (GO:0009083)3.18992430
60viral mRNA export from host cell nucleus (GO:0046784)3.18985854
61tRNA aminoacylation for protein translation (GO:0006418)3.18681328
62DNA replication checkpoint (GO:0000076)3.17640901
63rRNA methylation (GO:0031167)3.15843363
64antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15579407
65ribosomal large subunit biogenesis (GO:0042273)3.15066203
66amino acid activation (GO:0043038)3.15019542
67tRNA aminoacylation (GO:0043039)3.15019542
68rRNA modification (GO:0000154)3.11525817
69maturation of 5.8S rRNA (GO:0000460)3.10369112
70COPII vesicle coating (GO:0048208)3.09892214
71telomere maintenance via recombination (GO:0000722)3.07578271
72* translation (GO:0006412)3.07197492
73IMP metabolic process (GO:0046040)3.06974935
74negative regulation of acute inflammatory response (GO:0002674)3.05946751
75mitochondrial respiratory chain complex assembly (GO:0033108)3.05369633
76UDP-N-acetylglucosamine metabolic process (GO:0006047)3.05254917
77mannosylation (GO:0097502)3.05052589
78cellular ketone body metabolic process (GO:0046950)3.03603245
79dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.02645335
80telomere maintenance via telomere lengthening (GO:0010833)3.01588559
81folic acid metabolic process (GO:0046655)3.01278997
82ribonucleoprotein complex biogenesis (GO:0022613)3.00678217
83protein K6-linked ubiquitination (GO:0085020)3.00556424
84* positive regulation of nuclease activity (GO:0032075)2.99992989
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.99981547
86* activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.99368766
87positive regulation of actin filament depolymerization (GO:0030836)2.98879019
88guanosine-containing compound biosynthetic process (GO:1901070)2.98832406
897-methylguanosine mRNA capping (GO:0006370)2.97803562
90aldehyde catabolic process (GO:0046185)2.97377088
91protein N-linked glycosylation via asparagine (GO:0018279)2.96394070
92spliceosomal snRNP assembly (GO:0000387)2.94069085
93peptidyl-asparagine modification (GO:0018196)2.93694047
94pteridine-containing compound biosynthetic process (GO:0042559)2.92563434
95ketone body metabolic process (GO:1902224)2.92220469
96translational initiation (GO:0006413)2.91591787
97L-methionine salvage (GO:0071267)2.91375891
98L-methionine biosynthetic process (GO:0071265)2.91375891
99amino acid salvage (GO:0043102)2.91375891
100antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.91092629
101regulation of translation in response to stress (GO:0043555)2.89780147
102regulation of type B pancreatic cell apoptotic process (GO:2000674)2.89507444
103positive regulation of ligase activity (GO:0051351)2.89473691
104nucleobase-containing small molecule interconversion (GO:0015949)2.89099539
105rRNA processing (GO:0006364)2.88996029
106retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.88321494
107regulation of cellular amine metabolic process (GO:0033238)2.87925217
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86768632
109mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86538091
110RNA capping (GO:0036260)2.86454069
1117-methylguanosine RNA capping (GO:0009452)2.86454069
112regulation of cellular amino acid metabolic process (GO:0006521)2.83872500
113mitotic nuclear envelope disassembly (GO:0007077)2.83143100
114proline biosynthetic process (GO:0006561)2.82869606
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82759099
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82759099
117signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82759099
118cell cycle G1/S phase transition (GO:0044843)2.81581594
119G1/S transition of mitotic cell cycle (GO:0000082)2.81581594
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81472461
121RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81472461
122mitotic metaphase plate congression (GO:0007080)2.80708888
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80252844
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80252844
125* regulation of nuclease activity (GO:0032069)2.80213800
126positive regulation of cell cycle arrest (GO:0071158)2.79715780
127pseudouridine synthesis (GO:0001522)2.79162707
128deoxyribonucleotide biosynthetic process (GO:0009263)2.77696682
129rRNA metabolic process (GO:0016072)2.77301972
130mitotic recombination (GO:0006312)2.76941347
131translational termination (GO:0006415)2.76392460
132ER to Golgi vesicle-mediated transport (GO:0006888)2.75577365
133DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.74964596
134transcription-coupled nucleotide-excision repair (GO:0006283)2.74623020
135* endoplasmic reticulum unfolded protein response (GO:0030968)2.74567584
136signal transduction involved in DNA damage checkpoint (GO:0072422)2.74512197
137signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74512197
138negative regulation of neurological system process (GO:0031645)2.72550784
139cell redox homeostasis (GO:0045454)2.72101280
140protein N-linked glycosylation (GO:0006487)2.71756254
141regulation of ubiquitin-protein transferase activity (GO:0051438)2.70713241
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.70406201
143negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.69611704
144DNA double-strand break processing (GO:0000729)2.67803706
145regulation of ligase activity (GO:0051340)2.67136017
146inositol phosphate catabolic process (GO:0071545)2.66641204
147pteridine-containing compound metabolic process (GO:0042558)2.65946827
148tRNA metabolic process (GO:0006399)2.65682927
149nucleotide transmembrane transport (GO:1901679)2.64333950
150mitochondrial RNA metabolic process (GO:0000959)2.62626275
151positive regulation of glycolytic process (GO:0045821)2.62051858
152inositol phosphate dephosphorylation (GO:0046855)2.60095180
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.60095180
154keratinocyte development (GO:0003334)2.59417193
155somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56185571
156isotype switching (GO:0045190)2.56185571
157somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56185571
158mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.55162601
159anterograde synaptic vesicle transport (GO:0048490)2.54046657
160protein targeting to mitochondrion (GO:0006626)2.53382255
161tetrahydrofolate metabolic process (GO:0046653)2.48582418
162negative regulation of protein ubiquitination (GO:0031397)2.48565222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.15243904
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.93210573
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92848810
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76329090
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59283135
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.51777117
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.51704153
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42315852
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.32075259
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.31637139
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94139494
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90093749
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65753992
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62422086
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58556896
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52670800
17VDR_23849224_ChIP-Seq_CD4+_Human2.44268050
18* GABP_19822575_ChIP-Seq_HepG2_Human2.33784346
19XRN2_22483619_ChIP-Seq_HELA_Human2.28341097
20DCP1A_22483619_ChIP-Seq_HELA_Human2.26369244
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26265736
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21637797
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.16793954
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08103113
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06283941
26* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04324978
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00652574
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98908497
29FOXP3_21729870_ChIP-Seq_TREG_Human1.98442732
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97751046
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97211732
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94991202
33* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93757251
34* SRF_21415370_ChIP-Seq_HL-1_Mouse1.86359542
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.85527513
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83789859
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.81705377
38TTF2_22483619_ChIP-Seq_HELA_Human1.78735577
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.77518595
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75652837
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.73228742
42ZNF274_21170338_ChIP-Seq_K562_Hela1.70548747
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70387274
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.69578981
45CIITA_25753668_ChIP-Seq_RAJI_Human1.66737323
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66092247
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63726054
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.63384181
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61157797
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60642543
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60151718
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.59894448
53ELK1_19687146_ChIP-ChIP_HELA_Human1.59720710
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58676427
55TFEB_21752829_ChIP-Seq_HELA_Human1.55689585
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51169028
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.49194288
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48242741
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47624235
60MYC_22102868_ChIP-Seq_BL_Human1.47465070
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46287303
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46120761
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44368675
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42712166
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.41230938
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39069427
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.38960122
68MYC_18940864_ChIP-ChIP_HL60_Human1.36803665
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.36217146
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32943595
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32641877
72EWS_26573619_Chip-Seq_HEK293_Human1.32415707
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31878320
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31771128
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30918501
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29921049
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27293948
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.26737151
79AR_21909140_ChIP-Seq_LNCAP_Human1.25890181
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23630455
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23111850
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21841446
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21703219
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19889063
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19675047
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18584398
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17517930
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17386398
89SPI1_23547873_ChIP-Seq_NB4_Human1.17077645
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.15705671
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14623198
92FUS_26573619_Chip-Seq_HEK293_Human1.14617125
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13452043
94ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12689901
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11144772
96VDR_22108803_ChIP-Seq_LS180_Human1.09638067
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.08357874
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07890995
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05994108
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05296964
101IGF1R_20145208_ChIP-Seq_DFB_Human1.02310071
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01704032
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00597509
104* CDX2_22108803_ChIP-Seq_LS180_Human1.00509515
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98823866
106P300_19829295_ChIP-Seq_ESCs_Human0.98788591
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97273018
108TP53_22573176_ChIP-Seq_HFKS_Human0.96870060
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96745663
110CRX_20693478_ChIP-Seq_RETINA_Mouse0.96339412
111VDR_21846776_ChIP-Seq_THP-1_Human0.94645570
112ELF5_23300383_ChIP-Seq_T47D_Human0.93743000
113E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93498045
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93380583
115BRD4_25478319_ChIP-Seq_HGPS_Human0.92595386
116* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92427146
117AR_20517297_ChIP-Seq_VCAP_Human0.92259605
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91407575
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91269790
120SOX2_19829295_ChIP-Seq_ESCs_Human0.90418721
121NANOG_19829295_ChIP-Seq_ESCs_Human0.90418721
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89385679
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88812389
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88784933
125ER_23166858_ChIP-Seq_MCF-7_Human0.87992418
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87746362
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86341734
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85885821
129* FOXA1_25329375_ChIP-Seq_VCAP_Human0.85836828
130* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85836828
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85660351
132CBP_20019798_ChIP-Seq_JUKART_Human0.85660351
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85485971
134RBPJ_21746931_ChIP-Seq_IB4_Human0.85258638
135PHF8_20622853_ChIP-Seq_HELA_Human0.85249220
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.85208262
137* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83143413
138SALL4_22934838_ChIP-ChIP_CD34+_Human0.83101087
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82925800
140SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82467928
141CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82147351
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82120762
143STAT3_18555785_Chip-Seq_ESCs_Mouse0.80986136
144HTT_18923047_ChIP-ChIP_STHdh_Human0.80980651
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.80711354
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80466084
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79064198
148ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78797093
149SOX17_20123909_ChIP-Seq_XEN_Mouse0.76538036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.76540953
2MP0010234_abnormal_vibrissa_follicle3.87344263
3MP0009780_abnormal_chondrocyte_physiolo3.66801162
4MP0003195_calcinosis3.42712250
5MP0004957_abnormal_blastocyst_morpholog3.38370904
6MP0008438_abnormal_cutaneous_collagen2.88740136
7MP0003111_abnormal_nucleus_morphology2.88571467
8MP0000372_irregular_coat_pigmentation2.76777046
9MP0006054_spinal_hemorrhage2.74291329
10MP0003950_abnormal_plasma_membrane2.73968682
11MP0008007_abnormal_cellular_replicative2.60943393
12MP0003077_abnormal_cell_cycle2.58553005
13MP0005408_hypopigmentation2.57977544
14MP0005379_endocrine/exocrine_gland_phen2.49337819
15MP0010094_abnormal_chromosome_stability2.48863199
16MP0005220_abnormal_exocrine_pancreas2.43109173
17MP0002837_dystrophic_cardiac_calcinosis2.37942895
18MP0002876_abnormal_thyroid_physiology2.31276296
19MP0008932_abnormal_embryonic_tissue2.21025719
20MP0008877_abnormal_DNA_methylation2.18418088
21MP0002938_white_spotting2.04211835
22MP0006036_abnormal_mitochondrial_physio2.00215708
23MP0008058_abnormal_DNA_repair1.99866049
24MP0009333_abnormal_splenocyte_physiolog1.88198705
25MP0009697_abnormal_copulation1.83614163
26MP0002102_abnormal_ear_morphology1.80435920
27MP0005503_abnormal_tendon_morphology1.75629045
28MP0003123_paternal_imprinting1.75544768
29MP0002396_abnormal_hematopoietic_system1.71402490
30MP0005332_abnormal_amino_acid1.70722530
31MP0001661_extended_life_span1.70059060
32MP0001542_abnormal_bone_strength1.67376733
33MP0002090_abnormal_vision1.67299601
34MP0000678_abnormal_parathyroid_gland1.66946852
35MP0000516_abnormal_urinary_system1.65143020
36MP0005367_renal/urinary_system_phenotyp1.65143020
37MP0002877_abnormal_melanocyte_morpholog1.62274518
38MP0005075_abnormal_melanosome_morpholog1.61226234
39MP0002933_joint_inflammation1.59939639
40MP0001944_abnormal_pancreas_morphology1.58238035
41MP0002254_reproductive_system_inflammat1.57314206
42MP0000427_abnormal_hair_cycle1.56242510
43MP0005257_abnormal_intraocular_pressure1.56175845
44MP0008875_abnormal_xenobiotic_pharmacok1.51880607
45MP0000490_abnormal_crypts_of1.51346123
46MP0005058_abnormal_lysosome_morphology1.50017185
47MP0000015_abnormal_ear_pigmentation1.49643800
48MP0001730_embryonic_growth_arrest1.47696488
49MP0003786_premature_aging1.45049295
50MP0000350_abnormal_cell_proliferation1.39436966
51MP0003868_abnormal_feces_composition1.39252010
52MP0002693_abnormal_pancreas_physiology1.37960244
53MP0010386_abnormal_urinary_bladder1.36247729
54MP0005084_abnormal_gallbladder_morpholo1.35655211
55MP0002909_abnormal_adrenal_gland1.34363778
56MP0008057_abnormal_DNA_replication1.32631790
57MP0004272_abnormal_basement_membrane1.32054051
58MP0002166_altered_tumor_susceptibility1.30917343
59MP0000569_abnormal_digit_pigmentation1.30162087
60MP0008260_abnormal_autophagy1.29926180
61MP0001764_abnormal_homeostasis1.28381879
62MP0000858_altered_metastatic_potential1.27107596
63MP0003718_maternal_effect1.26774073
64MP0000358_abnormal_cell_content/1.26266234
65MP0005395_other_phenotype1.24594169
66MP0010352_gastrointestinal_tract_polyps1.23859258
67MP0010678_abnormal_skin_adnexa1.23838027
68MP0002080_prenatal_lethality1.23035065
69MP0006072_abnormal_retinal_apoptosis1.22819630
70MP0001697_abnormal_embryo_size1.22294386
71MP0010030_abnormal_orbit_morphology1.21805170
72MP0006035_abnormal_mitochondrial_morpho1.21382126
73MP0005174_abnormal_tail_pigmentation1.16495832
74MP0003941_abnormal_skin_development1.16101872
75MP0000538_abnormal_urinary_bladder1.15948506
76MP0005636_abnormal_mineral_homeostasis1.15657815
77MP0002060_abnormal_skin_morphology1.15646385
78MP0003011_delayed_dark_adaptation1.13765119
79MP0005645_abnormal_hypothalamus_physiol1.12114067
80MP0001533_abnormal_skeleton_physiology1.11843738
81MP0003186_abnormal_redox_activity1.11825507
82MP0002006_tumorigenesis1.08701436
83MP0003566_abnormal_cell_adhesion1.07729706
84MP0001672_abnormal_embryogenesis/_devel1.07108134
85MP0005380_embryogenesis_phenotype1.07108134
86MP0003984_embryonic_growth_retardation1.06425725
87MP0000465_gastrointestinal_hemorrhage1.05449596
88MP0005390_skeleton_phenotype1.05135958
89MP0000313_abnormal_cell_death1.04230985
90MP0002088_abnormal_embryonic_growth/wei1.02872824
91MP0005508_abnormal_skeleton_morphology1.01572072
92MP0004808_abnormal_hematopoietic_stem0.99131059
93MP0002019_abnormal_tumor_incidence0.98404964
94MP0001666_abnormal_nutrient_absorption0.98047528
95MP0005365_abnormal_bile_salt0.97870122
96MP0002168_other_aberrant_phenotype0.97776910
97MP0000371_diluted_coat_color0.97343981
98MP0005023_abnormal_wound_healing0.96934513
99MP0004782_abnormal_surfactant_physiolog0.96331445
100MP0005253_abnormal_eye_physiology0.95965217
101MP0003795_abnormal_bone_structure0.95332455
102MP0005551_abnormal_eye_electrophysiolog0.94356551
103MP0000013_abnormal_adipose_tissue0.93113345
104MP0002295_abnormal_pulmonary_circulatio0.93071782
105MP0002089_abnormal_postnatal_growth/wei0.92635342
106MP0003724_increased_susceptibility_to0.92281213
107MP0004264_abnormal_extraembryonic_tissu0.91854883
108MP0001984_abnormal_olfaction0.91836003
109MP0004134_abnormal_chest_morphology0.91327538
110MP0009384_cardiac_valve_regurgitation0.91320180
111MP0000613_abnormal_salivary_gland0.91087657
112MP0003436_decreased_susceptibility_to0.90636944
113MP0003646_muscle_fatigue0.90607574
114MP0001835_abnormal_antigen_presentation0.89365918
115MP0008872_abnormal_physiological_respon0.87020716
116MP0000647_abnormal_sebaceous_gland0.86842038
117MP0005389_reproductive_system_phenotype0.86808831
118MP0003119_abnormal_digestive_system0.86435510
119MP0003279_aneurysm0.86291113
120MP0002085_abnormal_embryonic_tissue0.86193844
121MP0002139_abnormal_hepatobiliary_system0.85879095
122MP0005275_abnormal_skin_tensile0.83769853
123MP0000681_abnormal_thyroid_gland0.83711442
124MP0002095_abnormal_skin_pigmentation0.83182473
125MP0005410_abnormal_fertilization0.83104818
126MP0003252_abnormal_bile_duct0.83013393
127MP0009672_abnormal_birth_weight0.82816005
128MP0000163_abnormal_cartilage_morphology0.82085610
129MP0004043_abnormal_pH_regulation0.82019612
130MP0002160_abnormal_reproductive_system0.80351980
131MP0010307_abnormal_tumor_latency0.79366322
132MP0002113_abnormal_skeleton_development0.79241294
133MP0002896_abnormal_bone_mineralization0.79123503
134MP0002111_abnormal_tail_morphology0.78556282
135MP0009046_muscle_twitch0.78308750
136MP0003656_abnormal_erythrocyte_physiolo0.77014695
137MP0002210_abnormal_sex_determination0.76831812
138MP0002084_abnormal_developmental_patter0.75540402
139MP0004197_abnormal_fetal_growth/weight/0.75144181
140MP0005171_absent_coat_pigmentation0.74900082
141MP0005384_cellular_phenotype0.74811300
142MP0002282_abnormal_trachea_morphology0.73377720
143MP0005646_abnormal_pituitary_gland0.72756701
144MP0000639_abnormal_adrenal_gland0.71920413
145MP0000689_abnormal_spleen_morphology0.71856067
146MP0001145_abnormal_male_reproductive0.71407262
147MP0009840_abnormal_foam_cell0.70887050
148MP0001243_abnormal_dermal_layer0.70553849
149MP0002163_abnormal_gland_morphology0.70451069
150MP0002398_abnormal_bone_marrow0.69638688
151MP0002086_abnormal_extraembryonic_tissu0.69543922
152MP0002234_abnormal_pharynx_morphology0.69110212
153MP0001756_abnormal_urination0.69060776
154MP0005397_hematopoietic_system_phenotyp0.68985520
155MP0001545_abnormal_hematopoietic_system0.68985520
156MP0002429_abnormal_blood_cell0.68734857
157MP0001929_abnormal_gametogenesis0.68525823
158MP0005621_abnormal_cell_physiology0.68300584
159MP0003806_abnormal_nucleotide_metabolis0.68120122
160MP0001879_abnormal_lymphatic_vessel0.67989670
161MP0004147_increased_porphyrin_level0.67783087
162MP0002132_abnormal_respiratory_system0.66999630
163MP0010329_abnormal_lipoprotein_level0.66832775
164MP0003763_abnormal_thymus_physiology0.66074264
165MP0002722_abnormal_immune_system0.66022010
166MP0001881_abnormal_mammary_gland0.65793456
167MP0003283_abnormal_digestive_organ0.65734669
168MP0001119_abnormal_female_reproductive0.65590289
169MP0000428_abnormal_craniofacial_morphol0.65545427
170MP0001986_abnormal_taste_sensitivity0.63241567

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)4.14894572
2Degeneration of anterior horn cells (HP:0002398)4.08348287
3Abnormality of the anterior horn cell (HP:0006802)4.08348287
4Hypoglycemic coma (HP:0001325)4.05955334
5Premature rupture of membranes (HP:0001788)4.05876122
6Type I transferrin isoform profile (HP:0003642)3.95188812
7Rough bone trabeculation (HP:0100670)3.89594669
8Hyperinsulinemic hypoglycemia (HP:0000825)3.76198109
9Progressive macrocephaly (HP:0004481)3.75461458
10Acute necrotizing encephalopathy (HP:0006965)3.71096785
11Protrusio acetabuli (HP:0003179)3.68982672
12Abnormal protein glycosylation (HP:0012346)3.64363078
13Abnormal glycosylation (HP:0012345)3.64363078
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.64363078
15Abnormal protein N-linked glycosylation (HP:0012347)3.64363078
16Ketoacidosis (HP:0001993)3.57486709
17Acute encephalopathy (HP:0006846)3.52313149
18Increased CSF lactate (HP:0002490)3.45524496
19Aplastic anemia (HP:0001915)3.32026093
20Mitochondrial inheritance (HP:0001427)3.29150331
21Symptomatic seizures (HP:0011145)3.28564504
22Abnormal mitochondria in muscle tissue (HP:0008316)3.25658983
23Abnormality of the pancreatic islet cells (HP:0006476)3.21207633
24Abnormality of endocrine pancreas physiology (HP:0012093)3.21207633
25Hypokinesia (HP:0002375)3.17318768
26Vertebral compression fractures (HP:0002953)3.16245159
27Cerebral hypomyelination (HP:0006808)3.15296863
28Cutaneous melanoma (HP:0012056)3.09916657
29Hyperglycemia (HP:0003074)3.06031940
30Cervical subluxation (HP:0003308)3.05325671
31Abnormality of methionine metabolism (HP:0010901)3.02034116
32Abnormality of glycolysis (HP:0004366)2.99273953
33Beaking of vertebral bodies (HP:0004568)2.96446638
34Metaphyseal dysplasia (HP:0100255)2.94491807
35Abnormal trabecular bone morphology (HP:0100671)2.93677014
36Birth length less than 3rd percentile (HP:0003561)2.89149594
37Flat capital femoral epiphysis (HP:0003370)2.86043982
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86025350
39Irregular epiphyses (HP:0010582)2.83316389
40Increased hepatocellular lipid droplets (HP:0006565)2.81770488
41Reduced antithrombin III activity (HP:0001976)2.80690579
42Cerebral edema (HP:0002181)2.80328700
43Neoplasm of the adrenal cortex (HP:0100641)2.80176173
44Sensory axonal neuropathy (HP:0003390)2.76877320
45Secondary amenorrhea (HP:0000869)2.75868398
46Carpal bone hypoplasia (HP:0001498)2.73986798
47Lipid accumulation in hepatocytes (HP:0006561)2.72616754
48Methylmalonic acidemia (HP:0002912)2.64599899
49Poor head control (HP:0002421)2.63890570
50Biconcave vertebral bodies (HP:0004586)2.62023867
51Hypoplasia of the pons (HP:0012110)2.61005044
52Abnormality of the umbilical cord (HP:0010881)2.58739971
53Large for gestational age (HP:0001520)2.58180478
54Hamartoma of the eye (HP:0010568)2.57631807
55Increased serum pyruvate (HP:0003542)2.57482138
56Increased serum lactate (HP:0002151)2.56391020
57Hypothermia (HP:0002045)2.52473918
58Neoplasm of the adrenal gland (HP:0100631)2.52386348
59Abnormality of the pons (HP:0007361)2.51334719
60Microretrognathia (HP:0000308)2.50561828
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49581432
62Pancreatic islet-cell hyperplasia (HP:0004510)2.49339648
63Soft skin (HP:0000977)2.46145840
6411 pairs of ribs (HP:0000878)2.41393560
65Trismus (HP:0000211)2.41084956
66Methylmalonic aciduria (HP:0012120)2.40741212
67Respiratory failure (HP:0002878)2.40637424
68Albinism (HP:0001022)2.33361098
69Lactic acidosis (HP:0003128)2.33272229
70Hypobetalipoproteinemia (HP:0003563)2.33200830
71Conjunctival hamartoma (HP:0100780)2.31132332
72Renal Fanconi syndrome (HP:0001994)2.30758443
73Slender long bone (HP:0003100)2.28209397
74Thrombocytosis (HP:0001894)2.27567091
75Ependymoma (HP:0002888)2.25807959
76Oral leukoplakia (HP:0002745)2.25525794
77Nonimmune hydrops fetalis (HP:0001790)2.25411786
78Ketosis (HP:0001946)2.24683474
79Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.23975287
80Absent epiphyses (HP:0010577)2.23975287
81Breast carcinoma (HP:0003002)2.18777061
82Premature graying of hair (HP:0002216)2.16304846
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15832148
84Multiple enchondromatosis (HP:0005701)2.15681038
85Irregular vertebral endplates (HP:0003301)2.13053987
86Small epiphyses (HP:0010585)2.12756149
87Abnormality of subcutaneous fat tissue (HP:0001001)2.12249889
88Abnormal pancreas size (HP:0012094)2.11144824
89Delayed gross motor development (HP:0002194)2.10710941
90Decreased activity of mitochondrial respiratory chain (HP:0008972)2.10552938
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.10552938
92Patent foramen ovale (HP:0001655)2.10362060
93Megaloblastic anemia (HP:0001889)2.09299083
94Hypoplasia of the fovea (HP:0007750)2.08668800
95Aplasia/Hypoplasia of the fovea (HP:0008060)2.08668800
96Abnormality of vitamin B metabolism (HP:0004340)2.06757914
97Abnormality of the metopic suture (HP:0005556)2.04862390
98Sparse eyelashes (HP:0000653)2.04618960
99Molar tooth sign on MRI (HP:0002419)2.03729128
100Abnormality of midbrain morphology (HP:0002418)2.03729128
101Muscular hypotonia of the trunk (HP:0008936)2.03524646
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03036010
103Diminished movement (HP:0002374)2.01685604
104Lethargy (HP:0001254)2.01433050
105Abnormality of the distal phalanges of the toes (HP:0010182)2.01137181
106Abnormality of the calcaneus (HP:0008364)2.01043127
107Postnatal microcephaly (HP:0005484)1.99990580
108Abnormality of dentin (HP:0010299)1.99873471
109Joint stiffness (HP:0001387)1.99634179
110Breast hypoplasia (HP:0003187)1.99489517
111Adrenal hypoplasia (HP:0000835)1.99399917
112Delayed epiphyseal ossification (HP:0002663)1.99051869
113Selective tooth agenesis (HP:0001592)1.98717563
114Reticulocytopenia (HP:0001896)1.98186710
115Hepatic necrosis (HP:0002605)1.97025286
116Short nail (HP:0001799)1.97023663
117Hepatocellular necrosis (HP:0001404)1.96443336
118Microvesicular hepatic steatosis (HP:0001414)1.95216215
119Amniotic constriction ring (HP:0009775)1.95194541
120Abnormality of placental membranes (HP:0011409)1.95194541
121Abnormality of the acetabulum (HP:0003170)1.94634811
122Spastic paraparesis (HP:0002313)1.90314331
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89822350
124Abnormality of alanine metabolism (HP:0010916)1.89822350
125Hyperalaninemia (HP:0003348)1.89822350
126Posterior subcapsular cataract (HP:0007787)1.89411317
127Steatorrhea (HP:0002570)1.88386546
128Epiphyseal dysplasia (HP:0002656)1.88094971
129Glossoptosis (HP:0000162)1.87725896
130Flattened epiphyses (HP:0003071)1.87692383
131Astrocytoma (HP:0009592)1.87482233
132Abnormality of the astrocytes (HP:0100707)1.87482233
133Bone marrow hypocellularity (HP:0005528)1.87278467
134Progressive muscle weakness (HP:0003323)1.86816682
135Entropion (HP:0000621)1.86301957
136Abnormal number of erythroid precursors (HP:0012131)1.85891002
137CNS demyelination (HP:0007305)1.85492479
138Abnormality of urine glucose concentration (HP:0011016)1.84576051
139Glycosuria (HP:0003076)1.84576051
140Pancreatic cysts (HP:0001737)1.84466882
141Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84246262
142Neoplasm of the pancreas (HP:0002894)1.84156571
143Exercise intolerance (HP:0003546)1.82388782
144Broad face (HP:0000283)1.81038598
145Platyspondyly (HP:0000926)1.80934844
146Metaphyseal cupping (HP:0003021)1.80684772
147Abnormality of the intrinsic pathway (HP:0010989)1.80566394
148Spinal muscular atrophy (HP:0007269)1.78658496
149Insulin-resistant diabetes mellitus (HP:0000831)1.78646386
150Aplasia/Hypoplasia of the patella (HP:0006498)1.78544897
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.78542281
152Patellar aplasia (HP:0006443)1.78515830
153Abnormal foot bone ossification (HP:0010675)1.78149612
154Pancreatic fibrosis (HP:0100732)1.76606345
155Abnormality of the vertebral endplates (HP:0005106)1.76466398
156Patchy hypopigmentation of hair (HP:0011365)1.76424401
157Abnormal rod and cone electroretinograms (HP:0008323)1.76394632
158Decreased skull ossification (HP:0004331)1.76175514
159Muscle fibrillation (HP:0010546)1.75916991
160Prominent metopic ridge (HP:0005487)1.75470239
161Generalized aminoaciduria (HP:0002909)1.75049391
162Poor suck (HP:0002033)1.74717432
163Renal cortical cysts (HP:0000803)1.74662959
164Glioma (HP:0009733)1.73567060
165Ankle contracture (HP:0006466)1.73426059
166Aplasia/hypoplasia of the uterus (HP:0008684)1.72974658
167Enlarged penis (HP:0000040)1.72966607
168Aseptic necrosis (HP:0010885)1.72699796
169Abnormal tarsal ossification (HP:0008369)1.71865899
170Colon cancer (HP:0003003)1.70692531
171Opisthotonus (HP:0002179)1.70318487
172Popliteal pterygium (HP:0009756)1.70209026
173Late onset (HP:0003584)1.69536329
174Hypomagnesemia (HP:0002917)1.69500910
175Ureteral duplication (HP:0000073)1.69168481
176Tongue fasciculations (HP:0001308)1.68628812
177Abnormality of the renal cortex (HP:0011035)1.68350026
178Dicarboxylic aciduria (HP:0003215)1.67850208
179Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67850208
180Abnormality of sulfur amino acid metabolism (HP:0004339)1.66992040
181Stillbirth (HP:0003826)1.66948922
182Abnormality of cells of the erythroid lineage (HP:0012130)1.65786263
183IgM deficiency (HP:0002850)1.64901167
184Aortic dissection (HP:0002647)1.64388279

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.75670891
2BUB14.21635459
3EIF2AK14.08643713
4NME23.94842576
5MST43.81474937
6EIF2AK33.43296110
7NUAK12.95429350
8TRIM282.94141065
9WEE12.69464680
10VRK22.67016115
11PASK2.58875306
12STK162.55040116
13ERN12.45445914
14IRAK32.41138375
15TSSK62.27916185
16MAP3K122.10804869
17FLT32.08453788
18PIM21.93849714
19PLK21.91734162
20RPS6KA41.91602089
21BRSK21.84783789
22PLK41.84403178
23BMPR1B1.79204046
24MAP4K21.79186124
25TESK21.76971588
26CDK81.74671602
27BCKDK1.73228477
28SRPK11.66748810
29SCYL21.62088918
30CDC71.59192823
31FER1.53447684
32EPHA21.49298203
33STK391.48627920
34FGFR21.48340204
35PBK1.48325215
36NEK21.43432536
37TAF11.41183009
38TESK11.41097849
39TLK11.40056684
40GRK11.36239538
41PAK31.35562135
42IRAK41.34410851
43BCR1.34134831
44ZAP701.33134974
45VRK11.33027422
46DYRK31.25517912
47TTK1.23829639
48TGFBR11.22943974
49PLK11.22020370
50WNK31.20828518
51ACVR1B1.20477706
52SIK31.19016173
53ZAK1.14594854
54MST1R1.12270668
55MAP3K31.06849263
56CDK71.05714686
57BRSK11.04572073
58PLK31.04025137
59CSNK1G11.01993371
60NEK11.01800149
61STK38L0.98223737
62BRAF0.98144119
63PHKG10.96274655
64PHKG20.96274655
65CSNK1G30.96188686
66NLK0.95047183
67KDR0.94103627
68NEK90.93372033
69MYLK0.92970135
70OXSR10.91907314
71AURKB0.91049519
72AURKA0.90517476
73MKNK10.90117811
74ATR0.85926638
75CHEK20.85815822
76STK240.84868778
77INSRR0.83511039
78MAPKAPK50.81882690
79MAP3K80.81267776
80PAK40.79022090
81IRAK10.78689075
82PRKD30.77158381
83MAP3K110.75094997
84PRKCE0.73949390
85CSNK1G20.73489852
86PRKCI0.73265803
87TRIB30.71467993
88CDK40.70989408
89TRPM70.68761085
90MKNK20.68409558
91NME10.68291185
92BTK0.67818065
93EIF2AK20.67655939
94ADRBK20.66783688
95JAK30.66518336
96DAPK10.66143563
97PAK10.65344834
98CSNK1A1L0.64766915
99ILK0.64095759
100LIMK10.63342196
101AKT30.62692451
102MAP3K20.60915081
103PDK30.60838516
104PDK40.60838516
105MAPKAPK30.59397110
106PNCK0.58985744
107RPS6KB20.58450859
108DYRK20.58441572
109CSNK2A10.57038280
110STK100.53819525
111TEC0.52045570
112PDK20.51442952
113CHEK10.49408144
114PKN20.48367996
115MET0.48187919
116STK30.47823156
117HIPK20.46672968
118CSNK2A20.45750276
119PTK20.45062357
120PINK10.44709318
121PIM10.44675039
122KIT0.44587935
123ABL20.42741752
124CAMK2D0.41536316
125ERBB30.40742623
126EEF2K0.39834217
127MAP2K20.39784385
128MAP4K10.39282749
129PAK20.39027949
130TBK10.38711242
131PTK2B0.38543807
132GRK50.37869291
133LRRK20.37390718
134TNIK0.35983269
135GSK3A0.35643999
136TGFBR20.35582632
137LMTK20.35482915
138RPS6KA50.34931204
139MUSK0.33141695
140CSF1R0.32910200
141FGFR10.32906950
142CAMKK20.32459824
143ROCK10.31785596
144CCNB10.31562233
145IRAK20.31358211
146CDK20.31218072
147ERBB40.30663345
148MAPKAPK20.30095471
149TAOK30.27499144
150ATM0.27304077

Predicted pathways (KEGG)

RankGene SetZ-score
1* Protein export_Homo sapiens_hsa030604.30144074
2DNA replication_Homo sapiens_hsa030303.59095712
3Proteasome_Homo sapiens_hsa030503.52764942
4RNA polymerase_Homo sapiens_hsa030203.37271020
5Mismatch repair_Homo sapiens_hsa034302.82237008
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.81194743
7Ribosome_Homo sapiens_hsa030102.68008251
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.60186375
9Fatty acid elongation_Homo sapiens_hsa000622.54007780
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42041448
11Base excision repair_Homo sapiens_hsa034102.41243330
12Pyrimidine metabolism_Homo sapiens_hsa002402.39860269
13RNA transport_Homo sapiens_hsa030132.37860749
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27556208
15N-Glycan biosynthesis_Homo sapiens_hsa005102.23403195
16Spliceosome_Homo sapiens_hsa030402.23229956
17Oxidative phosphorylation_Homo sapiens_hsa001902.19373526
18Homologous recombination_Homo sapiens_hsa034402.18803823
19Nucleotide excision repair_Homo sapiens_hsa034202.13650724
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08955346
21Maturity onset diabetes of the young_Homo sapiens_hsa049502.08075795
22One carbon pool by folate_Homo sapiens_hsa006702.07005959
23Propanoate metabolism_Homo sapiens_hsa006401.98288881
24Cell cycle_Homo sapiens_hsa041101.85014607
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.80097330
26Butanoate metabolism_Homo sapiens_hsa006501.79917553
27Folate biosynthesis_Homo sapiens_hsa007901.79807040
28Basal transcription factors_Homo sapiens_hsa030221.59866344
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59582396
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47650690
31Other glycan degradation_Homo sapiens_hsa005111.40757851
32Purine metabolism_Homo sapiens_hsa002301.37862761
33Antigen processing and presentation_Homo sapiens_hsa046121.32979949
34Steroid biosynthesis_Homo sapiens_hsa001001.31782826
35Selenocompound metabolism_Homo sapiens_hsa004501.25497627
36Fatty acid metabolism_Homo sapiens_hsa012121.20849255
37p53 signaling pathway_Homo sapiens_hsa041151.18517343
38RNA degradation_Homo sapiens_hsa030181.17348507
39Legionellosis_Homo sapiens_hsa051341.16871961
40Vitamin B6 metabolism_Homo sapiens_hsa007501.14802188
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.12205886
42Fanconi anemia pathway_Homo sapiens_hsa034601.11716039
43Sulfur relay system_Homo sapiens_hsa041221.10149389
44Peroxisome_Homo sapiens_hsa041461.09662301
45Pyruvate metabolism_Homo sapiens_hsa006201.09471229
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09035291
47Tryptophan metabolism_Homo sapiens_hsa003801.07133369
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03995779
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03811887
50Lysosome_Homo sapiens_hsa041421.03498519
51Epstein-Barr virus infection_Homo sapiens_hsa051691.03319544
52Alzheimers disease_Homo sapiens_hsa050101.02410402
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98846327
54Collecting duct acid secretion_Homo sapiens_hsa049660.96760271
55Galactose metabolism_Homo sapiens_hsa000520.96434786
56Pentose phosphate pathway_Homo sapiens_hsa000300.93103347
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91815415
58Fatty acid degradation_Homo sapiens_hsa000710.91022008
59Vibrio cholerae infection_Homo sapiens_hsa051100.90544897
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88973772
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88894741
62Non-homologous end-joining_Homo sapiens_hsa034500.86772842
63Regulation of autophagy_Homo sapiens_hsa041400.86517352
64mRNA surveillance pathway_Homo sapiens_hsa030150.86494181
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85627794
66Caffeine metabolism_Homo sapiens_hsa002320.84809407
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75592163
68Sulfur metabolism_Homo sapiens_hsa009200.74306245
69Fructose and mannose metabolism_Homo sapiens_hsa000510.72897751
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.72550680
71beta-Alanine metabolism_Homo sapiens_hsa004100.69886074
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69314655
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66583573
74Sphingolipid metabolism_Homo sapiens_hsa006000.66437403
75Biosynthesis of amino acids_Homo sapiens_hsa012300.65695447
76Thyroid cancer_Homo sapiens_hsa052160.64603460
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64331802
78Viral carcinogenesis_Homo sapiens_hsa052030.62826598
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62564841
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62223070
81Protein digestion and absorption_Homo sapiens_hsa049740.62192857
82Chemical carcinogenesis_Homo sapiens_hsa052040.60867734
83Herpes simplex infection_Homo sapiens_hsa051680.60372047
84Mineral absorption_Homo sapiens_hsa049780.59399166
85HTLV-I infection_Homo sapiens_hsa051660.58751594
86Nitrogen metabolism_Homo sapiens_hsa009100.58632468
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.57297470
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55413588
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.53449281
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52635782
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52356726
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.48601003
93Type I diabetes mellitus_Homo sapiens_hsa049400.47399601
94Circadian rhythm_Homo sapiens_hsa047100.46139525
95Phototransduction_Homo sapiens_hsa047440.46094230
96Bladder cancer_Homo sapiens_hsa052190.45341224
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45312320
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45253069
99Retinol metabolism_Homo sapiens_hsa008300.45000910
100Phagosome_Homo sapiens_hsa041450.41863559
101Metabolic pathways_Homo sapiens_hsa011000.41258224
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39750152
103Shigellosis_Homo sapiens_hsa051310.39601837
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39180485
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.39086112
106Glutathione metabolism_Homo sapiens_hsa004800.38191879
107Apoptosis_Homo sapiens_hsa042100.37901927
108Vitamin digestion and absorption_Homo sapiens_hsa049770.36137462
109Measles_Homo sapiens_hsa051620.35760705
110Arachidonic acid metabolism_Homo sapiens_hsa005900.35574185
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33292634
112Small cell lung cancer_Homo sapiens_hsa052220.32787405
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32056887
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31893462
115Fat digestion and absorption_Homo sapiens_hsa049750.31592513
116Renin-angiotensin system_Homo sapiens_hsa046140.31459267
117Arginine and proline metabolism_Homo sapiens_hsa003300.30713140
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30381838
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30361478
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29686042
121Hepatitis B_Homo sapiens_hsa051610.28627423
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28130956
123Carbon metabolism_Homo sapiens_hsa012000.28085443
124Huntingtons disease_Homo sapiens_hsa050160.27672532
125Starch and sucrose metabolism_Homo sapiens_hsa005000.27300517
126Parkinsons disease_Homo sapiens_hsa050120.26917316
127Oocyte meiosis_Homo sapiens_hsa041140.26895058
128ECM-receptor interaction_Homo sapiens_hsa045120.26529458
129Insulin secretion_Homo sapiens_hsa049110.26268057
130Ether lipid metabolism_Homo sapiens_hsa005650.26082710
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25301322
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24943319
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.24510434
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22134323
135Prostate cancer_Homo sapiens_hsa052150.20244094
1362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.19760506
137Systemic lupus erythematosus_Homo sapiens_hsa053220.19616590
138Malaria_Homo sapiens_hsa051440.19393718
139HIF-1 signaling pathway_Homo sapiens_hsa040660.18251749
140Primary immunodeficiency_Homo sapiens_hsa053400.17473006
141TGF-beta signaling pathway_Homo sapiens_hsa043500.17107399
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.16773242

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