SRPX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)9.05756009
2collagen fibril organization (GO:0030199)8.53960718
3protein heterotrimerization (GO:0070208)7.74727066
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)7.64775103
5chondrocyte development (GO:0002063)6.80450008
6bone trabecula formation (GO:0060346)6.17268905
7collagen catabolic process (GO:0030574)5.93319241
8collagen metabolic process (GO:0032963)5.88597825
9cartilage condensation (GO:0001502)5.66706293
10cell aggregation (GO:0098743)5.66706293
11multicellular organismal macromolecule metabolic process (GO:0044259)5.55425716
12multicellular organismal catabolic process (GO:0044243)5.48190292
13multicellular organismal metabolic process (GO:0044236)5.27596386
14skin morphogenesis (GO:0043589)5.24859719
15extracellular fibril organization (GO:0043206)5.04228955
16chondrocyte proliferation (GO:0035988)4.79834704
17extracellular matrix disassembly (GO:0022617)4.77648429
18positive regulation of extracellular matrix organization (GO:1903055)4.73947208
19endodermal cell differentiation (GO:0035987)4.69242985
20barbed-end actin filament capping (GO:0051016)4.45830481
21fibril organization (GO:0097435)4.39463227
22notochord development (GO:0030903)4.34641813
23sequestering of extracellular ligand from receptor (GO:0035581)4.34208059
24endothelial cell morphogenesis (GO:0001886)4.26274731
25vascular endothelial growth factor signaling pathway (GO:0038084)4.21088502
26peptidyl-proline hydroxylation (GO:0019511)4.17786059
27protein retention in ER lumen (GO:0006621)4.09335425
28keratan sulfate biosynthetic process (GO:0018146)4.09113145
29endocardial cushion morphogenesis (GO:0003203)4.06075025
30extracellular matrix assembly (GO:0085029)4.04254699
31maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.02897336
32cell adhesion mediated by integrin (GO:0033627)4.00036695
33limb bud formation (GO:0060174)3.96468520
34type B pancreatic cell proliferation (GO:0044342)3.93093619
35cartilage development (GO:0051216)3.92855755
36extracellular matrix organization (GO:0030198)3.85760514
37extracellular structure organization (GO:0043062)3.84287856
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.82798282
39positive regulation of cartilage development (GO:0061036)3.80692909
40regulation of extracellular matrix disassembly (GO:0010715)3.77644056
41negative regulation of chondrocyte differentiation (GO:0032331)3.77437075
42substrate-dependent cell migration (GO:0006929)3.75837900
43endochondral ossification (GO:0001958)3.72535747
44replacement ossification (GO:0036075)3.72535747
45embryonic skeletal joint morphogenesis (GO:0060272)3.70906452
46chondroitin sulfate biosynthetic process (GO:0030206)3.70279689
47dermatan sulfate biosynthetic process (GO:0030208)3.68639378
48mesenchyme morphogenesis (GO:0072132)3.67167572
49wound healing, spreading of epidermal cells (GO:0035313)3.64162710
50short-term memory (GO:0007614)3.58947963
51regulation of gonadotropin secretion (GO:0032276)3.58806648
52protein maturation by protein folding (GO:0022417)3.56841963
53cellular response to BMP stimulus (GO:0071773)3.56309160
54response to BMP (GO:0071772)3.56309160
55tooth mineralization (GO:0034505)3.54039405
56negative regulation of fatty acid transport (GO:2000192)3.53808113
57regulation of integrin-mediated signaling pathway (GO:2001044)3.53292184
58hemidesmosome assembly (GO:0031581)3.53198912
59regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.52789207
60negative regulation of cartilage development (GO:0061037)3.50185933
61keratan sulfate metabolic process (GO:0042339)3.50019256
62positive regulation of chondrocyte differentiation (GO:0032332)3.49259871
63protein hydroxylation (GO:0018126)3.47200144
64skeletal system development (GO:0001501)3.43381726
65response to gravity (GO:0009629)3.40768112
66regulation of cartilage development (GO:0061035)3.40766639
67regulation of chondrocyte differentiation (GO:0032330)3.40435794
68kidney mesenchyme development (GO:0072074)3.40147574
69adhesion of symbiont to host (GO:0044406)3.39663827
70protein localization to endosome (GO:0036010)3.31808054
71dermatan sulfate metabolic process (GO:0030205)3.31649776
72positive regulation of blood vessel endothelial cell migration (GO:0043536)3.30845479
73glycosaminoglycan catabolic process (GO:0006027)3.30282163
74proteoglycan metabolic process (GO:0006029)3.28809600
75negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.24896950
76peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.24618146
77metanephric mesenchyme development (GO:0072075)3.24330672
78venous blood vessel morphogenesis (GO:0048845)3.24286210
79chondrocyte differentiation (GO:0002062)3.23834031
80negative regulation of smooth muscle cell migration (GO:0014912)3.21283580
81muscle cell migration (GO:0014812)3.19346743
82cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.17309411
83axon extension involved in axon guidance (GO:0048846)3.16375698
84neuron projection extension involved in neuron projection guidance (GO:1902284)3.16375698
85endothelial cell chemotaxis (GO:0035767)3.15108148
86basement membrane organization (GO:0071711)3.15007020
87apoptotic cell clearance (GO:0043277)3.13832089
88ossification (GO:0001503)3.13810118
89blood vessel maturation (GO:0001955)3.13456302
90regulation of plasminogen activation (GO:0010755)3.11986216
91cell-substrate junction assembly (GO:0007044)3.11235428
92glycosaminoglycan biosynthetic process (GO:0006024)3.11126175
93regulation of extracellular matrix organization (GO:1903053)3.09913791
94aminoglycan catabolic process (GO:0006026)3.09867371
95positive regulation of astrocyte differentiation (GO:0048711)3.09260871
96cell proliferation involved in kidney development (GO:0072111)3.07999659
97positive regulation of endothelial cell apoptotic process (GO:2000353)3.07844576
98aminoglycan biosynthetic process (GO:0006023)3.06241180
99mesenchymal-epithelial cell signaling (GO:0060638)3.04744264
100negative regulation of focal adhesion assembly (GO:0051895)3.04635539
101negative regulation of cell junction assembly (GO:1901889)3.04635539
102negative regulation of adherens junction organization (GO:1903392)3.04635539
103positive regulation of epithelial to mesenchymal transition (GO:0010718)3.04598113
104sulfur compound catabolic process (GO:0044273)3.04518276
105positive regulation of receptor recycling (GO:0001921)3.03449421
106lymphangiogenesis (GO:0001946)3.03024423
107positive regulation of osteoblast proliferation (GO:0033690)2.99878639
108protein trimerization (GO:0070206)2.99839919
109extracellular regulation of signal transduction (GO:1900115)2.99709093
110extracellular negative regulation of signal transduction (GO:1900116)2.99709093
111glomerular basement membrane development (GO:0032836)2.98874141
112cellular response to vitamin (GO:0071295)2.97861763
113craniofacial suture morphogenesis (GO:0097094)2.94236682
114positive regulation of p38MAPK cascade (GO:1900745)2.94089658
115virion attachment to host cell (GO:0019062)2.93892148
116adhesion of symbiont to host cell (GO:0044650)2.93892148
117iron ion import (GO:0097286)2.92197448
118negative regulation of homotypic cell-cell adhesion (GO:0034111)2.91683347
119negative regulation of gluconeogenesis (GO:0045721)2.90716786
120nucleotide-sugar biosynthetic process (GO:0009226)2.90611096
121cardiac epithelial to mesenchymal transition (GO:0060317)2.88121594
122substrate adhesion-dependent cell spreading (GO:0034446)2.87829637
123vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.87619421
124sprouting angiogenesis (GO:0002040)2.86919982
125negative regulation of catenin import into nucleus (GO:0035414)2.86056704
126positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.82264639
127negative regulation of smooth muscle cell differentiation (GO:0051151)2.81451121
128smooth muscle tissue development (GO:0048745)2.80701935
129hyaluronan catabolic process (GO:0030214)2.80421584
130Golgi transport vesicle coating (GO:0048200)2.80268692
131COPI coating of Golgi vesicle (GO:0048205)2.80268692
132wound healing, spreading of cells (GO:0044319)2.78661911
133trabecula formation (GO:0060343)2.78489046
134cell migration involved in sprouting angiogenesis (GO:0002042)2.78411827
135positive regulation of stem cell differentiation (GO:2000738)2.78266916
136epithelial to mesenchymal transition (GO:0001837)2.77834892
137endothelial cell proliferation (GO:0001935)2.77187848
138cortical actin cytoskeleton organization (GO:0030866)2.76820185
139stress fiber assembly (GO:0043149)2.75788328
140cell migration involved in heart development (GO:0060973)2.75295951
141regulation of biomineral tissue development (GO:0070167)2.75180589
142positive regulation of endothelial cell migration (GO:0010595)2.75144345
143planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73373793
144retina vasculature morphogenesis in camera-type eye (GO:0061299)2.73370434
145regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.72420732
146low-density lipoprotein particle clearance (GO:0034383)2.72309786
147G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.72104791
148glial cell migration (GO:0008347)2.71129010
149negative regulation of nitric-oxide synthase activity (GO:0051001)2.70909965
150regulation of axon extension involved in axon guidance (GO:0048841)2.70170335
151endocardial cushion development (GO:0003197)2.66424779
152regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.62478703
153dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61524685
154membrane raft organization (GO:0031579)2.60372484
155cortical cytoskeleton organization (GO:0030865)2.59978589
156hypotonic response (GO:0006971)2.58828147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.30942995
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.18219814
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.20794384
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.60674472
5AR_21572438_ChIP-Seq_LNCaP_Human2.91061659
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.81050283
7* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.67158927
8CJUN_26792858_Chip-Seq_BT549_Human2.65613393
9CLOCK_20551151_ChIP-Seq_293T_Human2.58605702
10* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.47556853
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.47550103
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.45807153
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43589300
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.33509971
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.23617463
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.19830458
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18388335
18CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.16440517
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01180565
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.93345833
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91731021
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91731021
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89883166
24EP300_21415370_ChIP-Seq_HL-1_Mouse1.84140305
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83621147
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.80978532
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78592369
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.77079554
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.77079554
30BRD4_25478319_ChIP-Seq_HGPS_Human1.76782592
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72616802
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69276253
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67056684
34TP53_18474530_ChIP-ChIP_U2OS_Human1.65706693
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60640467
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60396658
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59992311
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52514171
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49109379
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.48144288
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48018776
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47237968
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46762210
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44786063
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43085353
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40442058
47SOX2_20726797_ChIP-Seq_SW620_Human1.40032585
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38809375
49JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37203748
50TP53_22127205_ChIP-Seq_IMR90_Human1.36141765
51NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.35339668
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34832128
53TP53_23651856_ChIP-Seq_MEFs_Mouse1.34569382
54MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.33761093
55LXR_22292898_ChIP-Seq_THP-1_Human1.33077868
56RACK7_27058665_Chip-Seq_MCF-7_Human1.30656461
57SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29094054
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27696884
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27533855
60GATA1_22025678_ChIP-Seq_K562_Human1.26019092
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.25025541
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24015182
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23491246
64ATF3_27146783_Chip-Seq_COLON_Human1.23401036
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23166957
66ZNF263_19887448_ChIP-Seq_K562_Human1.23033443
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22372941
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19893813
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19741645
70TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19377983
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.18408994
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.16817060
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.16817060
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15054803
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15054803
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14028272
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13905963
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13819403
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.13678176
80SA1_22415368_ChIP-Seq_MEFs_Mouse1.13287068
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12724542
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12144973
83RXR_22108803_ChIP-Seq_LS180_Human1.11848470
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11810269
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11383725
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11008000
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.10439995
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08669413
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08619334
90PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.07088826
91ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05467250
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04562670
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04523879
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03622865
95SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03533153
96UBF1/2_26484160_Chip-Seq_HMECs_Human1.03131007
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.02251513
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.00287625
99TP53_16413492_ChIP-PET_HCT116_Human0.99875547
100VDR_24787735_ChIP-Seq_THP-1_Human0.99653807
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99094481
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98582562
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97415055
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96681446
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96590001
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.95148699
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94768452
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94429735
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93623337
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93490767
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92871203
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.92066682
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91676398
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.90577125
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89178080
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.89133205
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89102730
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.89036832
119EGR1_19032775_ChIP-ChIP_M12_Human0.87493516
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.86690670
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86520394
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.85411760
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84549859
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83003892
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79634168
126TP63_23658742_ChIP-Seq_EP156T_Human0.79156702
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78945758
128KDM2B_26808549_Chip-Seq_K562_Human0.78907865
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78810805
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78076699
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77667644
132CSB_26484114_Chip-Seq_FIBROBLAST_Human0.77510117
133TCF4_18268006_ChIP-ChIP_LS174T_Human0.76708955
134RING1B_27294783_Chip-Seq_ESCs_Mouse0.75756068
135* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.75521573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.97981892
2MP0005503_abnormal_tendon_morphology7.32709051
3MP0005275_abnormal_skin_tensile5.94047550
4MP0004134_abnormal_chest_morphology3.04220382
5MP0003279_aneurysm3.02711748
6MP0004272_abnormal_basement_membrane2.88683296
7MP0002933_joint_inflammation2.87500743
8MP0009250_abnormal_appendicular_skeleto2.77712650
9MP0001958_emphysema2.77551975
10MP0005508_abnormal_skeleton_morphology2.71766824
11MP0003705_abnormal_hypodermis_morpholog2.66437617
12MP0002282_abnormal_trachea_morphology2.66086934
13MP0006054_spinal_hemorrhage2.45849341
14MP0001542_abnormal_bone_strength2.38472230
15MP0002877_abnormal_melanocyte_morpholog2.37401467
16MP0002108_abnormal_muscle_morphology2.32916263
17MP0000163_abnormal_cartilage_morphology2.26808427
18MP0005257_abnormal_intraocular_pressure2.12371665
19MP0003950_abnormal_plasma_membrane2.12342523
20MP0002896_abnormal_bone_mineralization2.08684818
21MP0009384_cardiac_valve_regurgitation2.08063332
22MP0002115_abnormal_skeleton_extremities2.07217821
23MP0000751_myopathy1.97519360
24MP0005390_skeleton_phenotype1.87845875
25MP0002060_abnormal_skin_morphology1.83234164
26MP0005171_absent_coat_pigmentation1.77734647
27MP0002113_abnormal_skeleton_development1.65937383
28MP0001299_abnormal_eye_distance/1.65165640
29MP0009780_abnormal_chondrocyte_physiolo1.62509313
30MP0004858_abnormal_nervous_system1.62195087
31MP0003385_abnormal_body_wall1.58271166
32MP0003283_abnormal_digestive_organ1.50561381
33MP0000762_abnormal_tongue_morphology1.46276502
34MP0001533_abnormal_skeleton_physiology1.43811173
35MP0003566_abnormal_cell_adhesion1.43368488
36MP0004233_abnormal_muscle_weight1.42416095
37MP0002109_abnormal_limb_morphology1.38463899
38MP0005023_abnormal_wound_healing1.37125498
39MP0001270_distended_abdomen1.36661850
40MP0001243_abnormal_dermal_layer1.35083445
41MP0005670_abnormal_white_adipose1.34916623
42MP0003646_muscle_fatigue1.32440091
43MP0010030_abnormal_orbit_morphology1.30067505
44MP0002295_abnormal_pulmonary_circulatio1.28661379
45MP0002089_abnormal_postnatal_growth/wei1.27236316
46MP0003795_abnormal_bone_structure1.22784644
47MP0002998_abnormal_bone_remodeling1.20864531
48MP0005165_increased_susceptibility_to1.19417004
49MP0001661_extended_life_span1.18260181
50MP0003123_paternal_imprinting1.17561604
51MP0003755_abnormal_palate_morphology1.15744411
52MP0003942_abnormal_urinary_system1.13693421
53MP0000343_altered_response_to1.13113868
54MP0000013_abnormal_adipose_tissue1.12528900
55MP0003828_pulmonary_edema1.12506336
56MP0001849_ear_inflammation1.12307083
57MP0000049_abnormal_middle_ear1.11650945
58MP0000534_abnormal_ureter_morphology1.09766322
59MP0002116_abnormal_craniofacial_bone1.08838313
60MP0002932_abnormal_joint_morphology1.08345005
61MP0005623_abnormal_meninges_morphology1.07223947
62MP0002249_abnormal_larynx_morphology1.05591871
63MP0005197_abnormal_uvea_morphology1.04365510
64MP0004510_myositis1.02259366
65MP0000767_abnormal_smooth_muscle0.99874030
66MP0000432_abnormal_head_morphology0.99549055
67MP0005330_cardiomyopathy0.98384071
68MP0003122_maternal_imprinting0.96372969
69MP0003935_abnormal_craniofacial_develop0.93557723
70MP0009840_abnormal_foam_cell0.92752366
71MP0008775_abnormal_heart_ventricle0.90562287
72MP0005058_abnormal_lysosome_morphology0.90110055
73MP0001915_intracranial_hemorrhage0.89667538
74MP0010352_gastrointestinal_tract_polyps0.89160091
75MP0000428_abnormal_craniofacial_morphol0.89132762
76MP0003191_abnormal_cellular_cholesterol0.88312667
77MP0002111_abnormal_tail_morphology0.85936296
78MP0003045_fibrosis0.82308743
79MP0004185_abnormal_adipocyte_glucose0.82307893
80MP0000733_abnormal_muscle_development0.82248748
81MP0002114_abnormal_axial_skeleton0.79866601
82MP0002233_abnormal_nose_morphology0.79692511
83MP0003091_abnormal_cell_migration0.79676934
84MP0000462_abnormal_digestive_system0.79331495
85MP0004036_abnormal_muscle_relaxation0.79050784
86MP0005164_abnormal_response_to0.76885604
87MP0000747_muscle_weakness0.75909530
88MP0002972_abnormal_cardiac_muscle0.75832067
89MP0009053_abnormal_anal_canal0.74871784
90MP0003937_abnormal_limbs/digits/tail_de0.74212628
91MP0010368_abnormal_lymphatic_system0.73831987
92MP0005369_muscle_phenotype0.71704186
93MP0005595_abnormal_vascular_smooth0.70513770
94MP0003300_gastrointestinal_ulcer0.69738725
95MP0000749_muscle_degeneration0.69362135
96MP0000249_abnormal_blood_vessel0.68826923
97MP0000467_abnormal_esophagus_morphology0.68167887
98MP0002909_abnormal_adrenal_gland0.68039651
99MP0000003_abnormal_adipose_tissue0.67674753
100MP0001879_abnormal_lymphatic_vessel0.67179491
101MP0003115_abnormal_respiratory_system0.66827855
102MP0005193_abnormal_anterior_eye0.66560580
103MP0002837_dystrophic_cardiac_calcinosis0.65503440
104MP0000750_abnormal_muscle_regeneration0.65322217
105MP0004484_altered_response_of0.65071631
106MP0003941_abnormal_skin_development0.64987029
107MP0005620_abnormal_muscle_contractility0.64874935
108MP0002925_abnormal_cardiovascular_devel0.64765301
109MP0002269_muscular_atrophy0.64554125
110MP0002168_other_aberrant_phenotype0.63784372
111MP0003329_amyloid_beta_deposits0.63278097
112MP0004084_abnormal_cardiac_muscle0.62055117
113MP0005388_respiratory_system_phenotype0.61061719
114MP0002133_abnormal_respiratory_system0.61061719
115MP0003448_altered_tumor_morphology0.60951990
116MP0001175_abnormal_lung_morphology0.60334404
117MP0001177_atelectasis0.59582466
118MP0002938_white_spotting0.58962781
119MP0000858_altered_metastatic_potential0.57780666
120MP0002128_abnormal_blood_circulation0.56798124
121MP0000759_abnormal_skeletal_muscle0.56440316
122MP0005375_adipose_tissue_phenotype0.54806824
123MP0005076_abnormal_cell_differentiation0.51533830
124MP0008004_abnormal_stomach_pH0.51447111
125MP0004087_abnormal_muscle_fiber0.48372158
126MP0000516_abnormal_urinary_system0.47922366
127MP0005367_renal/urinary_system_phenotyp0.47922366
128MP0010771_integument_phenotype0.47691158
129MP0006138_congestive_heart_failure0.47657633
130MP0001614_abnormal_blood_vessel0.47304416
131MP0000566_synostosis0.46938317

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.61814078
2Protrusio acetabuli (HP:0003179)6.01769987
3Irregular epiphyses (HP:0010582)5.77153744
4Premature rupture of membranes (HP:0001788)5.47093985
5Vitreoretinal degeneration (HP:0000655)5.09161730
6Hypoplastic ischia (HP:0003175)5.06086648
7Neonatal short-limb short stature (HP:0008921)5.04919824
8Cupped ribs (HP:0000887)4.66797466
9Small epiphyses (HP:0010585)4.65500695
10Abnormality of the ischium (HP:0003174)4.47955822
11Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.19952176
12Arterial tortuosity (HP:0005116)4.09539917
13Abnormal tarsal ossification (HP:0008369)3.91104787
14Osteoarthritis (HP:0002758)3.86921112
15Flat capital femoral epiphysis (HP:0003370)3.68770043
16Follicular hyperkeratosis (HP:0007502)3.66467245
17Mild short stature (HP:0003502)3.63796248
18Cervical subluxation (HP:0003308)3.62082143
19Ankle contracture (HP:0006466)3.61459629
20Aortic dissection (HP:0002647)3.56906967
21Delayed epiphyseal ossification (HP:0002663)3.53006207
22Soft skin (HP:0000977)3.47669309
23Flat acetabular roof (HP:0003180)3.37014527
24Genu varum (HP:0002970)3.29233878
25Increased variability in muscle fiber diameter (HP:0003557)3.28316398
26Atrophic scars (HP:0001075)3.16741196
27Metaphyseal cupping (HP:0003021)3.12846693
28Type 1 muscle fiber predominance (HP:0003803)3.05467998
29Abnormal foot bone ossification (HP:0010675)3.03185690
30Flattened epiphyses (HP:0003071)3.00247619
31Broad metatarsal (HP:0001783)2.98818611
32Coxa vara (HP:0002812)2.94596324
33Abnormality of the vertebral endplates (HP:0005106)2.92324366
34Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.92239972
35Abnormality of femoral epiphyses (HP:0006499)2.92239972
36Abnormality of the phalanges of the 2nd finger (HP:0009541)2.91601698
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.90800581
38Osteolytic defects of the hand bones (HP:0009699)2.90800581
39Abnormality of dentin (HP:0010299)2.87618706
40Bladder diverticulum (HP:0000015)2.86334080
41Platyspondyly (HP:0000926)2.86242558
42Thoracolumbar scoliosis (HP:0002944)2.85036383
43Wrist flexion contracture (HP:0001239)2.84814204
44Wormian bones (HP:0002645)2.84392851
45Abnormality of skeletal muscle fiber size (HP:0012084)2.83546192
46Genu recurvatum (HP:0002816)2.80136932
47Short nail (HP:0001799)2.73692794
48Biconcave vertebral bodies (HP:0004586)2.72324516
49Beaking of vertebral bodies (HP:0004568)2.71006218
50Shallow orbits (HP:0000586)2.70062306
51Mitral valve prolapse (HP:0001634)2.66516605
52Limited hip movement (HP:0008800)2.65154571
53Mesomelia (HP:0003027)2.64836562
54Metaphyseal dysplasia (HP:0100255)2.63644188
55Spondylolisthesis (HP:0003302)2.62844489
56Absent epiphyses (HP:0010577)2.62644115
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.62644115
58Aortic aneurysm (HP:0004942)2.60768518
59Abnormality of the acetabulum (HP:0003170)2.60065351
60Blue sclerae (HP:0000592)2.59767431
61Elbow flexion contracture (HP:0002987)2.59376430
62Irregular vertebral endplates (HP:0003301)2.58390141
63Abnormality of the epiphysis of the femoral head (HP:0010574)2.55246724
64Hip contracture (HP:0003273)2.55125751
65Arthropathy (HP:0003040)2.53365648
66Generalized amyotrophy (HP:0003700)2.51881873
67Peritonitis (HP:0002586)2.51555277
68Ovoid vertebral bodies (HP:0003300)2.50538572
69Short femoral neck (HP:0100864)2.49902322
70Absent frontal sinuses (HP:0002688)2.49812469
71Slender build (HP:0001533)2.48786650
72Abnormality of carpal bone ossification (HP:0006257)2.48589242
73Abnormal vertebral ossification (HP:0100569)2.48324299
74Ectopia lentis (HP:0001083)2.45383151
75Vertebral compression fractures (HP:0002953)2.45233955
76Spinal rigidity (HP:0003306)2.43849057
77Dilatation of the ascending aorta (HP:0005111)2.38430052
78Fragile skin (HP:0001030)2.37845782
79Distal lower limb muscle weakness (HP:0009053)2.36395219
80Mitral regurgitation (HP:0001653)2.35984836
81Abnormality of the pubic bones (HP:0003172)2.35508092
82Abnormality of the femoral head (HP:0003368)2.34198769
83Aneurysm (HP:0002617)2.33028271
84Abnormality of the 2nd finger (HP:0004100)2.32167455
85Limited elbow extension (HP:0001377)2.30746037
86Metaphyseal irregularity (HP:0003025)2.29543990
87Wide anterior fontanel (HP:0000260)2.27764534
88Upper limb amyotrophy (HP:0009129)2.26384822
89Distal upper limb amyotrophy (HP:0007149)2.26384822
90Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.25887952
91Broad long bones (HP:0005622)2.25182969
92Lumbar hyperlordosis (HP:0002938)2.24944853
93Protuberant abdomen (HP:0001538)2.24519788
94Increased connective tissue (HP:0009025)2.23990437
95Bowel diverticulosis (HP:0005222)2.22390431
96Natal tooth (HP:0000695)2.21240709
97Ulnar bowing (HP:0003031)2.20873080
98Aortic regurgitation (HP:0001659)2.20600883
99Cerebral aneurysm (HP:0004944)2.20370899
100Hypoventilation (HP:0002791)2.18151838
101Hypoplasia of the iris (HP:0007676)2.17079363
102Overgrowth (HP:0001548)2.16284931
103Mitral stenosis (HP:0001718)2.15886854
104Spinal cord compression (HP:0002176)2.15774295
105Thin ribs (HP:0000883)2.15273583
106Reduced subcutaneous adipose tissue (HP:0003758)2.15204921
107Abnormality of the proximal phalanges of the hand (HP:0009834)2.14696766
108Abnormal ossification of hand bones (HP:0005921)2.14529769
109Joint laxity (HP:0001388)2.13293319
110Aortic valve stenosis (HP:0001650)2.12912570
111Abnormal hand bone ossification (HP:0010660)2.12216716
112Exostoses (HP:0100777)2.11568383
113Hypoplasia of the odontoid process (HP:0003311)2.08373693
114Hand muscle atrophy (HP:0009130)2.06400150
115Delayed cranial suture closure (HP:0000270)2.05647404
116Achilles tendon contracture (HP:0001771)2.05003108
117Hyperextensible skin (HP:0000974)2.04458118
118Protruding ear (HP:0000411)2.02628166
119Mildly elevated creatine phosphokinase (HP:0008180)2.01111483
120Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.99807154
121Limb-girdle muscle weakness (HP:0003325)1.98755257
122Joint stiffness (HP:0001387)1.97509906
123Broad phalanx (HP:0006009)1.97107195
124Waddling gait (HP:0002515)1.97081815
125Broad ribs (HP:0000885)1.95917305
126Decreased skull ossification (HP:0004331)1.95451320
127Abnormal delivery (HP:0001787)1.93291239
128Abnormality of complement system (HP:0005339)1.92592374
129Thin skin (HP:0000963)1.92551168
130Vascular tortuosity (HP:0004948)1.91188270
131Pulmonary artery stenosis (HP:0004415)1.88135007
132Distal lower limb amyotrophy (HP:0008944)1.88089536
133Disproportionate tall stature (HP:0001519)1.86406663
134Round ear (HP:0100830)1.85690016
135Inguinal hernia (HP:0000023)1.81858792
136Abnormality of skull ossification (HP:0002703)1.80087560
137Asymmetric septal hypertrophy (HP:0001670)1.78852210
138Venous abnormality (HP:0002624)1.78352320
139Cardiovascular calcification (HP:0011915)1.77271357
140Osteopenia (HP:0000938)1.76825477
141Striae distensae (HP:0001065)1.74933994
142Acanthosis nigricans (HP:0000956)1.72904167
143Abnormality of the Achilles tendon (HP:0005109)1.72550087
144Long toe (HP:0010511)1.72302944
145Delayed closure of the anterior fontanelle (HP:0001476)1.72270592
146Breech presentation (HP:0001623)1.72083777
147Glucose intolerance (HP:0000833)1.70521070
148Coronal craniosynostosis (HP:0004440)1.67137698
149Back pain (HP:0003418)1.66986142
150Abnormality of the umbilical cord (HP:0010881)1.65989417
151Short clavicles (HP:0000894)1.64820457
152Limb-girdle muscle atrophy (HP:0003797)1.64099437
153Camptodactyly of toe (HP:0001836)1.63348689
154Narrow nasal bridge (HP:0000446)1.62769344
155Bradycardia (HP:0001662)1.61920873
156Spinal cord lesions (HP:0100561)1.61304669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.23090540
2MAP3K34.66025270
3LATS13.26249494
4STK38L3.24251838
5EPHA32.83061551
6TRIB32.81940906
7SIK12.58854910
8NME12.50514669
9MOS2.47486224
10STK242.41852911
11TTN2.39282509
12PDGFRA2.33663779
13EPHB22.23107305
14ERBB42.12823012
15ERN11.99469204
16LATS21.96501429
17PRKG21.85191716
18PRPF4B1.83974415
19ARAF1.80212610
20TGFBR21.77185142
21NUAK11.69905516
22STK31.67256864
23PRKD31.63067084
24MET1.56082634
25FER1.44136307
26TAOK21.42562638
27PIK3CA1.41653313
28ERBB31.38594279
29IRAK31.27644192
30MYLK1.26315350
31ROCK11.25881391
32PLK21.22318323
33RPS6KA41.19426577
34FLT31.18029081
35TRPM71.17315373
36DMPK1.13815229
37PAK21.12447275
38PAK61.11478714
39FGFR21.08847091
40EPHA21.07645352
41MAPK71.06356243
42MAPKAPK31.05896089
43MAP3K61.01930213
44STK380.98417574
45ICK0.98105127
46NEK90.98088387
47EPHB10.97310754
48PRKCH0.96756757
49FGFR10.96630275
50PDGFRB0.95232827
51PTK2B0.94813430
52TESK20.93907709
53PKN20.93752393
54PRKD20.93222260
55PIM20.92495146
56BMX0.89712391
57KDR0.88811860
58FGFR30.87143820
59CAMK1D0.86839703
60GRK50.84064269
61GSK3A0.82372307
62RIPK10.80848315
63LIMK10.80057374
64PTK20.79304872
65NME20.79164747
66PDK20.77509614
67FRK0.75189671
68ILK0.73385299
69DAPK30.70511569
70DYRK1A0.66883609
71RPS6KA20.66438043
72PTK60.65119282
73PIK3CG0.64288298
74MST1R0.64174636
75MST40.61150579
76LMTK20.60760040
77PAK10.59560133
78MAPK120.59170687
79CLK10.58089444
80MAP3K120.58007431
81LRRK20.55879214
82BRAF0.53354098
83MAPK40.51702991
84SCYL20.51304687
85INSR0.50082958
86TGFBR10.48364301
87ROCK20.48141422
88TIE10.47452724
89EEF2K0.47369857
90MTOR0.47064198
91NEK10.46812330
92CAMK1G0.45875902
93CSK0.45581332
94TESK10.45369913
95JAK10.45028899
96ADRBK10.44652071
97CAMKK20.44525121
98STK100.42911516
99ZAP700.42877669
100PRKD10.42753371
101PAK30.41068871
102CDK80.40978451
103CDK60.40659355
104PHKG20.40364793
105PHKG10.40364793
106MAP2K30.40070988
107CAMK2G0.39229158
108FGFR40.38888349
109RET0.38605829
110NTRK10.38260545
111MKNK20.37991576
112OBSCN0.37582689
113PRKCE0.37259403
114CDC42BPA0.37033933
115IGF1R0.36432958
116KSR20.36180226
117NLK0.35829978
118SMG10.35000988
119MUSK0.34868174
120CDK150.34336373
121MAP3K80.34294810
122MAPKAPK20.33224473
123PAK40.32724571
124SRC0.32564791
125CDK11A0.32141467
126CDK140.30582666
127CDK180.30510191
128TAOK10.30241492
129MAPK10.30165371
130STK390.29615536
131MAP2K10.29221133
132WNK10.29027002
133ABL20.25598962
134ABL10.25594157
135ZAK0.24968556
136EIF2AK20.24619292
137MAPK30.24368376
138KIT0.23895037
139PBK0.22473187

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045126.68875531
2Protein digestion and absorption_Homo sapiens_hsa049745.29639803
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.83446064
4Focal adhesion_Homo sapiens_hsa045103.39682188
5Malaria_Homo sapiens_hsa051442.74974045
6TGF-beta signaling pathway_Homo sapiens_hsa043502.21292833
7PI3K-Akt signaling pathway_Homo sapiens_hsa041512.06105854
8Proteoglycans in cancer_Homo sapiens_hsa052051.95021957
9Basal cell carcinoma_Homo sapiens_hsa052171.94059860
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.87674883
11Amoebiasis_Homo sapiens_hsa051461.85694556
12Hedgehog signaling pathway_Homo sapiens_hsa043401.85142791
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81533890
14Dilated cardiomyopathy_Homo sapiens_hsa054141.72573026
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69819503
16Prion diseases_Homo sapiens_hsa050201.68035406
17Hippo signaling pathway_Homo sapiens_hsa043901.60284843
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57929429
19Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.40150793
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39401547
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33395700
22Adherens junction_Homo sapiens_hsa045201.26825064
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23136530
24Small cell lung cancer_Homo sapiens_hsa052221.09185942
25Renin-angiotensin system_Homo sapiens_hsa046141.08378755
26Wnt signaling pathway_Homo sapiens_hsa043101.07785369
27Sphingolipid metabolism_Homo sapiens_hsa006001.05830920
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03728482
29Protein export_Homo sapiens_hsa030601.03421302
30Pentose phosphate pathway_Homo sapiens_hsa000301.02637530
31Starch and sucrose metabolism_Homo sapiens_hsa005000.98980693
32MicroRNAs in cancer_Homo sapiens_hsa052060.98969110
33Bladder cancer_Homo sapiens_hsa052190.97164437
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95679012
35Platelet activation_Homo sapiens_hsa046110.91858414
36Sulfur relay system_Homo sapiens_hsa041220.87971564
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.84387730
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84204743
39Phagosome_Homo sapiens_hsa041450.84187295
40Shigellosis_Homo sapiens_hsa051310.83987078
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83847124
42Glutathione metabolism_Homo sapiens_hsa004800.83022260
43Sulfur metabolism_Homo sapiens_hsa009200.82610707
44Pathways in cancer_Homo sapiens_hsa052000.82392382
45Melanoma_Homo sapiens_hsa052180.82373449
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.81232046
47Thyroid hormone synthesis_Homo sapiens_hsa049180.81184814
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80716524
49Fatty acid elongation_Homo sapiens_hsa000620.80411779
50Prostate cancer_Homo sapiens_hsa052150.80190460
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79987264
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78433221
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77537843
54N-Glycan biosynthesis_Homo sapiens_hsa005100.77058338
55Melanogenesis_Homo sapiens_hsa049160.76854096
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75347711
57Endocytosis_Homo sapiens_hsa041440.74687372
58Pertussis_Homo sapiens_hsa051330.74359823
59Ovarian steroidogenesis_Homo sapiens_hsa049130.72804603
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72491375
61Complement and coagulation cascades_Homo sapiens_hsa046100.72488240
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72248275
63Axon guidance_Homo sapiens_hsa043600.68503893
64Other glycan degradation_Homo sapiens_hsa005110.67875645
65Insulin resistance_Homo sapiens_hsa049310.66491457
66Arginine and proline metabolism_Homo sapiens_hsa003300.64606240
67Thyroid cancer_Homo sapiens_hsa052160.64016396
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63115374
69Viral myocarditis_Homo sapiens_hsa054160.62643740
70Tyrosine metabolism_Homo sapiens_hsa003500.62468103
71Rap1 signaling pathway_Homo sapiens_hsa040150.61034035
72Toxoplasmosis_Homo sapiens_hsa051450.60346473
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59208100
74Arachidonic acid metabolism_Homo sapiens_hsa005900.58501866
75p53 signaling pathway_Homo sapiens_hsa041150.58468485
76Folate biosynthesis_Homo sapiens_hsa007900.56991873
77Biosynthesis of amino acids_Homo sapiens_hsa012300.53569524
78TNF signaling pathway_Homo sapiens_hsa046680.52981702
79Lysine degradation_Homo sapiens_hsa003100.52387549
80HTLV-I infection_Homo sapiens_hsa051660.52187686
81Chronic myeloid leukemia_Homo sapiens_hsa052200.51779114
82Steroid biosynthesis_Homo sapiens_hsa001000.51706629
83HIF-1 signaling pathway_Homo sapiens_hsa040660.51464284
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.51460137
85Galactose metabolism_Homo sapiens_hsa000520.51290853
86Gap junction_Homo sapiens_hsa045400.50190379
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.49477274
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49256207
89Endometrial cancer_Homo sapiens_hsa052130.49194211
90PPAR signaling pathway_Homo sapiens_hsa033200.48907348
91Salmonella infection_Homo sapiens_hsa051320.48813608
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48461423
93Fructose and mannose metabolism_Homo sapiens_hsa000510.48319183
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47777999
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46902370
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46214499
97AMPK signaling pathway_Homo sapiens_hsa041520.46158975
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44656130
99Glioma_Homo sapiens_hsa052140.44491746
100Vibrio cholerae infection_Homo sapiens_hsa051100.43834107
101Notch signaling pathway_Homo sapiens_hsa043300.43328564
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43064938
103Pancreatic cancer_Homo sapiens_hsa052120.43056584
104VEGF signaling pathway_Homo sapiens_hsa043700.41878045
105Tight junction_Homo sapiens_hsa045300.40997235
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.40542335
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39146093
108Apoptosis_Homo sapiens_hsa042100.38282289
109Carbon metabolism_Homo sapiens_hsa012000.37940850
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.37667186
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.37368883
112Renal cell carcinoma_Homo sapiens_hsa052110.36447160
113Ras signaling pathway_Homo sapiens_hsa040140.36418877
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32655847
115cAMP signaling pathway_Homo sapiens_hsa040240.29689628
116Renin secretion_Homo sapiens_hsa049240.29562237
117Estrogen signaling pathway_Homo sapiens_hsa049150.29422043
118Hepatitis B_Homo sapiens_hsa051610.29394311
119Oxytocin signaling pathway_Homo sapiens_hsa049210.28954076
120Lysosome_Homo sapiens_hsa041420.28019807
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27247293
122FoxO signaling pathway_Homo sapiens_hsa040680.27062259
123Osteoclast differentiation_Homo sapiens_hsa043800.26747674
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26136648
125Olfactory transduction_Homo sapiens_hsa047400.23620637
126Legionellosis_Homo sapiens_hsa051340.23195218
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.22897419
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21079296
129Insulin signaling pathway_Homo sapiens_hsa049100.20671808
130GnRH signaling pathway_Homo sapiens_hsa049120.20626736

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