SRR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.00787018
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.00787018
3L-phenylalanine metabolic process (GO:0006558)5.68247023
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.68247023
5aromatic amino acid family catabolic process (GO:0009074)5.51579173
6indole-containing compound catabolic process (GO:0042436)5.09731558
7indolalkylamine catabolic process (GO:0046218)5.09731558
8tryptophan catabolic process (GO:0006569)5.09731558
9bile acid biosynthetic process (GO:0006699)4.88405211
10kynurenine metabolic process (GO:0070189)4.86045271
11tryptophan metabolic process (GO:0006568)4.73984746
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70224551
13glyoxylate metabolic process (GO:0046487)4.57352398
14protein-cofactor linkage (GO:0018065)4.48192282
15alpha-linolenic acid metabolic process (GO:0036109)4.38694783
16cysteine metabolic process (GO:0006534)4.36521373
17high-density lipoprotein particle remodeling (GO:0034375)4.24635015
18cellular ketone body metabolic process (GO:0046950)4.21036935
19urea metabolic process (GO:0019627)4.17644536
20urea cycle (GO:0000050)4.17644536
21sulfur amino acid catabolic process (GO:0000098)4.14550412
22protein neddylation (GO:0045116)4.14287782
23bile acid metabolic process (GO:0008206)4.12849714
24lysine catabolic process (GO:0006554)4.07960012
25lysine metabolic process (GO:0006553)4.07960012
26positive regulation of mitochondrial fission (GO:0090141)4.00831707
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.00209479
28serine family amino acid catabolic process (GO:0009071)3.97995745
29glutamate metabolic process (GO:0006536)3.95918796
30regulation of fibrinolysis (GO:0051917)3.95539088
31aromatic amino acid family metabolic process (GO:0009072)3.94420828
32cullin deneddylation (GO:0010388)3.93573374
33negative regulation of fibrinolysis (GO:0051918)3.92511585
34dicarboxylic acid biosynthetic process (GO:0043650)3.92426197
35presynaptic membrane assembly (GO:0097105)3.90870217
36protein deneddylation (GO:0000338)3.83360528
37homocysteine metabolic process (GO:0050667)3.83331071
38chaperone-mediated protein transport (GO:0072321)3.82092763
39complement activation, alternative pathway (GO:0006957)3.81999722
40nitrogen cycle metabolic process (GO:0071941)3.81991484
41alpha-amino acid catabolic process (GO:1901606)3.80795414
42regulation of protein activation cascade (GO:2000257)3.79151418
43postsynaptic membrane organization (GO:0001941)3.74640053
44benzene-containing compound metabolic process (GO:0042537)3.74583798
45cellular glucuronidation (GO:0052695)3.74531178
46amino-acid betaine metabolic process (GO:0006577)3.73572593
47peptidyl-glutamic acid carboxylation (GO:0017187)3.72931655
48protein carboxylation (GO:0018214)3.72931655
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.72185290
50regulation of cholesterol esterification (GO:0010872)3.71267189
51mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69635597
52coenzyme catabolic process (GO:0009109)3.69325803
53tyrosine metabolic process (GO:0006570)3.67418732
54reverse cholesterol transport (GO:0043691)3.67364925
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.65596393
56ketone body metabolic process (GO:1902224)3.63079147
57drug catabolic process (GO:0042737)3.61765335
58indolalkylamine metabolic process (GO:0006586)3.59202432
59cellular amino acid catabolic process (GO:0009063)3.59177176
60protein-lipid complex remodeling (GO:0034368)3.57196203
61macromolecular complex remodeling (GO:0034367)3.57196203
62plasma lipoprotein particle remodeling (GO:0034369)3.57196203
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55017024
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.55017024
65NADH dehydrogenase complex assembly (GO:0010257)3.55017024
66protein complex biogenesis (GO:0070271)3.52909270
67regulation of complement activation (GO:0030449)3.52655818
68cellular modified amino acid catabolic process (GO:0042219)3.51342221
69response to nitrosative stress (GO:0051409)3.49311588
70amine catabolic process (GO:0009310)3.47884648
71cellular biogenic amine catabolic process (GO:0042402)3.47884648
72nonmotile primary cilium assembly (GO:0035058)3.45979622
73triglyceride homeostasis (GO:0070328)3.44904509
74acylglycerol homeostasis (GO:0055090)3.44904509
75short-chain fatty acid metabolic process (GO:0046459)3.43018894
76regulation of cilium movement (GO:0003352)3.42350277
77energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42216988
78ATP synthesis coupled proton transport (GO:0015986)3.42216988
79regulation of triglyceride catabolic process (GO:0010896)3.42062334
80uronic acid metabolic process (GO:0006063)3.41547417
81glucuronate metabolic process (GO:0019585)3.41547417
82regulation of bile acid biosynthetic process (GO:0070857)3.40103100
83presynaptic membrane organization (GO:0097090)3.36666308
84negative regulation of cholesterol transport (GO:0032375)3.35022855
85negative regulation of sterol transport (GO:0032372)3.35022855
86pyrimidine nucleobase catabolic process (GO:0006208)3.32533601
87exogenous drug catabolic process (GO:0042738)3.31841898
88protein polyglutamylation (GO:0018095)3.30557674
89drug transmembrane transport (GO:0006855)3.30476430
90bile acid and bile salt transport (GO:0015721)3.29734196
91phospholipid efflux (GO:0033700)3.26881456
92neuron cell-cell adhesion (GO:0007158)3.26095371
93intraciliary transport (GO:0042073)3.24630434
94mitochondrial respiratory chain complex assembly (GO:0033108)3.24086477
95cholesterol efflux (GO:0033344)3.22489313
96arginine metabolic process (GO:0006525)3.21763140
97aspartate family amino acid catabolic process (GO:0009068)3.20969198
98negative regulation of lipase activity (GO:0060192)3.20621925
99acetyl-CoA metabolic process (GO:0006084)3.20486413
100epithelial cilium movement (GO:0003351)3.19230638
101indole-containing compound metabolic process (GO:0042430)3.17123904
102water-soluble vitamin biosynthetic process (GO:0042364)3.14730157
103organic acid catabolic process (GO:0016054)3.14415067
104carboxylic acid catabolic process (GO:0046395)3.14415067
105xenobiotic catabolic process (GO:0042178)3.13792419
106RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.12615835
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.12615835
108ethanol oxidation (GO:0006069)3.11219348
109sequestering of actin monomers (GO:0042989)3.09150324
110neurotransmitter-gated ion channel clustering (GO:0072578)3.08445582
111respiratory electron transport chain (GO:0022904)3.07433420
112retinal ganglion cell axon guidance (GO:0031290)3.07210296
113negative regulation of telomere maintenance (GO:0032205)3.06328443
114low-density lipoprotein particle remodeling (GO:0034374)3.05082063
115electron transport chain (GO:0022900)3.04061409
116DNA damage response, detection of DNA damage (GO:0042769)3.02365651
117cilium morphogenesis (GO:0060271)3.01443849
118urate metabolic process (GO:0046415)2.99947438
119* serine family amino acid metabolic process (GO:0009069)2.98533066
120plasma lipoprotein particle clearance (GO:0034381)2.98158935
121flavonoid metabolic process (GO:0009812)2.97041478
122imidazole-containing compound metabolic process (GO:0052803)2.95947711
123phospholipid homeostasis (GO:0055091)2.95133236
124nucleobase catabolic process (GO:0046113)2.94701398
125monocarboxylic acid catabolic process (GO:0072329)2.94201939
126resolution of meiotic recombination intermediates (GO:0000712)2.93370160
1272-oxoglutarate metabolic process (GO:0006103)2.91408677
128dicarboxylic acid catabolic process (GO:0043649)2.86949437
129very long-chain fatty acid metabolic process (GO:0000038)2.86845247
130cofactor catabolic process (GO:0051187)2.85910823
131positive regulation of lipid catabolic process (GO:0050996)2.85412036
132C4-dicarboxylate transport (GO:0015740)2.85086044
133axoneme assembly (GO:0035082)2.85057780
134NAD biosynthetic process (GO:0009435)2.83913710
135fatty acid beta-oxidation (GO:0006635)2.79511698
136cytolysis (GO:0019835)2.79067313
137fatty acid oxidation (GO:0019395)2.78424536
138transmission of nerve impulse (GO:0019226)2.76988106
139carnitine metabolic process (GO:0009437)2.76397592
140cilium movement (GO:0003341)2.75551317
141chromatin remodeling at centromere (GO:0031055)2.75168292
142mechanosensory behavior (GO:0007638)2.75114995
143epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74231592
144ubiquinone metabolic process (GO:0006743)2.73428836
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71741994
146DNA double-strand break processing (GO:0000729)2.69607314
147replication fork processing (GO:0031297)2.66961893
148cell proliferation in forebrain (GO:0021846)2.65382918
149ubiquinone biosynthetic process (GO:0006744)2.63367101
150establishment of mitochondrion localization (GO:0051654)2.58539502
151axonal fasciculation (GO:0007413)2.58098813
152auditory behavior (GO:0031223)2.57546802
153platelet dense granule organization (GO:0060155)2.57271887
154gamma-aminobutyric acid transport (GO:0015812)2.57046085
155anterograde synaptic vesicle transport (GO:0048490)2.56553489
156GTP biosynthetic process (GO:0006183)2.55684928
157somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55287886
158somatic hypermutation of immunoglobulin genes (GO:0016446)2.55287886
159regulation of development, heterochronic (GO:0040034)2.53149875
160neuron recognition (GO:0008038)2.51162766
161CENP-A containing nucleosome assembly (GO:0034080)2.49734606
162behavioral response to ethanol (GO:0048149)2.49587536
163respiratory chain complex IV assembly (GO:0008535)2.47883244
164anterograde axon cargo transport (GO:0008089)2.46592418
165protein localization to synapse (GO:0035418)2.46325643
166proteasome assembly (GO:0043248)2.46182467
167cilium organization (GO:0044782)2.43919013
168regulation of telomere maintenance (GO:0032204)2.43684915
169regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43649585
170regulation of mitochondrial fission (GO:0090140)2.43195419
171cilium assembly (GO:0042384)2.42156308
172behavioral response to nicotine (GO:0035095)2.41827082
173nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.41682776
174regulation of timing of cell differentiation (GO:0048505)2.39222097
175L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.35693134
176limb bud formation (GO:0060174)2.35653990
177cerebral cortex radially oriented cell migration (GO:0021799)2.33809405
178preassembly of GPI anchor in ER membrane (GO:0016254)2.32947618
179C-terminal protein lipidation (GO:0006501)2.32333618
180response to auditory stimulus (GO:0010996)2.32253550
181exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32137386
182axonemal dynein complex assembly (GO:0070286)2.28216268
183kinetochore assembly (GO:0051382)2.27300444
184regulation of microtubule-based movement (GO:0060632)2.26908716
185positive regulation of synapse assembly (GO:0051965)2.26128437
186brain morphogenesis (GO:0048854)2.25801020
187aldehyde catabolic process (GO:0046185)2.25270123
188short-term memory (GO:0007614)2.24246264
189purine nucleoside triphosphate biosynthetic process (GO:0009145)2.23922787
190intracellular protein transmembrane import (GO:0044743)2.23857071
191GPI anchor metabolic process (GO:0006505)2.23279048
192calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.22584876
193cytochrome complex assembly (GO:0017004)2.22540380
194synapse assembly (GO:0007416)2.22520125
195purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.20481383
196protein localization to cilium (GO:0061512)2.19026581
197kinetochore organization (GO:0051383)2.18113817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.36193904
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.53160615
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.60236712
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59287786
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.53105821
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30922591
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17137296
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.15291148
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.13217897
10ZNF274_21170338_ChIP-Seq_K562_Hela3.05703341
11GBX2_23144817_ChIP-Seq_PC3_Human3.00571183
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.87691432
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80399576
14EZH2_22144423_ChIP-Seq_EOC_Human2.69908634
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69413282
16IGF1R_20145208_ChIP-Seq_DFB_Human2.50148849
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.40932970
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.18539553
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14765761
20FUS_26573619_Chip-Seq_HEK293_Human2.14269300
21EWS_26573619_Chip-Seq_HEK293_Human2.11486993
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05631053
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04342603
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04201665
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01851556
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96754816
27TAF15_26573619_Chip-Seq_HEK293_Human1.89583812
28ELK1_19687146_ChIP-ChIP_HELA_Human1.87523991
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.82893850
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.76357764
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75002937
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74298298
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69347167
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69155058
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67329597
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66393302
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66338638
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65244153
39VDR_22108803_ChIP-Seq_LS180_Human1.64274674
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61488916
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61023191
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61023191
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59486354
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56650846
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56436860
46REST_21632747_ChIP-Seq_MESCs_Mouse1.55430623
47DROSHA_22980978_ChIP-Seq_HELA_Human1.55408743
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.55380618
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55284057
50MYC_18940864_ChIP-ChIP_HL60_Human1.50262598
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49780879
52IRF1_19129219_ChIP-ChIP_H3396_Human1.49520848
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47691079
54VDR_23849224_ChIP-Seq_CD4+_Human1.47439780
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.43431266
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.39971892
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39513090
58AR_21572438_ChIP-Seq_LNCaP_Human1.36413307
59CBP_20019798_ChIP-Seq_JUKART_Human1.36245673
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36245673
61RNF2_27304074_Chip-Seq_NSC_Mouse1.35540294
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34452936
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33210788
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32481931
65HTT_18923047_ChIP-ChIP_STHdh_Human1.32095554
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.32072346
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.31567051
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31067602
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.30781083
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30700958
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29387184
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.28958077
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27949039
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27772634
75* SMAD4_21799915_ChIP-Seq_A2780_Human1.25426254
76TP53_22573176_ChIP-Seq_HFKS_Human1.23438386
77* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22373901
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.20042210
79P300_19829295_ChIP-Seq_ESCs_Human1.18857822
80* SRF_21415370_ChIP-Seq_HL-1_Mouse1.17796846
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17733489
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16726420
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.15527807
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15340344
85GABP_19822575_ChIP-Seq_HepG2_Human1.14858913
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14099287
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.13662107
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13118068
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12798419
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12420196
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11891771
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10982437
93ER_23166858_ChIP-Seq_MCF-7_Human1.10640857
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09229913
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.08440016
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07181582
97FOXP3_21729870_ChIP-Seq_TREG_Human1.06243136
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05976024
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05625279
100NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05625279
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04725905
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04211724
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04159350
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03936447
105AR_25329375_ChIP-Seq_VCAP_Human1.03452839
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02683382
107HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02279767
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01145307
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01008052
110SMAD3_21741376_ChIP-Seq_EPCs_Human0.99876782
111SOX2_21211035_ChIP-Seq_LN229_Gbm0.98624271
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96992769
113JUN_21703547_ChIP-Seq_K562_Human0.96962326
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96759519
115BCAT_22108803_ChIP-Seq_LS180_Human0.96661347
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94985955
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94942608
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94858803
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94539096
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93886874
121TCF4_22108803_ChIP-Seq_LS180_Human0.93677187
122TAL1_26923725_Chip-Seq_HPCs_Mouse0.93136686
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.92995436
124STAT3_23295773_ChIP-Seq_U87_Human0.92871297
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92737626
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91959885
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91959885
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91529233
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88999702
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88021316
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.87358271
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86936911
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86426173
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85682453
135PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85540915
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84557004
137HNF4A_19822575_ChIP-Seq_HepG2_Human0.84517399
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.84487743
139AHR_22903824_ChIP-Seq_MCF-7_Human0.83866079
140AR_19668381_ChIP-Seq_PC3_Human0.83104167
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82832806
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.81180328
143TCF4_23295773_ChIP-Seq_U87_Human0.80821003
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.80791382
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.79293432
146KDM2B_26808549_Chip-Seq_REH_Human0.77601557
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76343390
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75711132
149AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75252613
150DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75097088
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.74306530
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.73662745
153PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73289951
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.73260515
155* RUNX2_22187159_ChIP-Seq_PCA_Human0.72894401
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.72473221
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.72023175
158P53_22387025_ChIP-Seq_ESCs_Mouse0.71883937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.74589358
2MP0005360_urolithiasis6.32447365
3MP0005085_abnormal_gallbladder_physiolo5.23304700
4MP0005365_abnormal_bile_salt5.13664400
5MP0008875_abnormal_xenobiotic_pharmacok4.73529374
6MP0001529_abnormal_vocalization3.50700571
7MP0003252_abnormal_bile_duct3.31036617
8MP0010329_abnormal_lipoprotein_level2.97720392
9MP0004859_abnormal_synaptic_plasticity2.82487411
10MP0003195_calcinosis2.64906474
11MP0006292_abnormal_olfactory_placode2.57239512
12* MP0005332_abnormal_amino_acid2.52629374
13MP0003806_abnormal_nucleotide_metabolis2.46859765
14MP0003880_abnormal_central_pattern2.27852946
15MP0003136_yellow_coat_color2.10846854
16MP0002822_catalepsy2.00415947
17MP0005083_abnormal_biliary_tract1.93136394
18MP0004019_abnormal_vitamin_homeostasis1.92472083
19MP0009840_abnormal_foam_cell1.91323904
20MP0001666_abnormal_nutrient_absorption1.89433654
21MP0008058_abnormal_DNA_repair1.86803663
22* MP0003635_abnormal_synaptic_transmissio1.85073211
23MP0008789_abnormal_olfactory_epithelium1.82523149
24MP0002102_abnormal_ear_morphology1.80298452
25MP0003122_maternal_imprinting1.79683400
26MP0002118_abnormal_lipid_homeostasis1.79155658
27MP0006072_abnormal_retinal_apoptosis1.76882697
28MP0009745_abnormal_behavioral_response1.76857515
29MP0003121_genomic_imprinting1.71910555
30MP0002653_abnormal_ependyma_morphology1.71293760
31MP0000569_abnormal_digit_pigmentation1.70468626
32MP0004270_analgesia1.66512523
33* MP0002063_abnormal_learning/memory/cond1.65970042
34MP0000049_abnormal_middle_ear1.65121916
35MP0005394_taste/olfaction_phenotype1.64992658
36MP0005499_abnormal_olfactory_system1.64992658
37MP0002938_white_spotting1.59132061
38MP0002234_abnormal_pharynx_morphology1.57452353
39MP0002064_seizures1.53215816
40MP0005253_abnormal_eye_physiology1.51074306
41MP0003868_abnormal_feces_composition1.51069438
42MP0002138_abnormal_hepatobiliary_system1.51056822
43MP0000631_abnormal_neuroendocrine_gland1.48552335
44MP0002876_abnormal_thyroid_physiology1.47989007
45MP0005584_abnormal_enzyme/coenzyme_acti1.47953694
46MP0009780_abnormal_chondrocyte_physiolo1.46750651
47MP0008877_abnormal_DNA_methylation1.44075258
48MP0005646_abnormal_pituitary_gland1.43122674
49MP0003329_amyloid_beta_deposits1.43099688
50MP0004133_heterotaxia1.42772841
51MP0004043_abnormal_pH_regulation1.42735141
52MP0003191_abnormal_cellular_cholesterol1.40612850
53MP0001293_anophthalmia1.37049900
54MP0000955_abnormal_spinal_cord1.34413219
55MP0000609_abnormal_liver_physiology1.34313912
56MP0000566_synostosis1.33523816
57MP0002184_abnormal_innervation1.32478198
58MP0005319_abnormal_enzyme/_coenzyme1.31505565
59MP0001968_abnormal_touch/_nociception1.30943352
60* MP0002572_abnormal_emotion/affect_behav1.30271970
61MP0002233_abnormal_nose_morphology1.26701106
62MP0002163_abnormal_gland_morphology1.25758275
63MP0003787_abnormal_imprinting1.24465945
64MP0001764_abnormal_homeostasis1.23802168
65MP0001486_abnormal_startle_reflex1.23745165
66MP0000372_irregular_coat_pigmentation1.23649803
67MP0000026_abnormal_inner_ear1.22747885
68MP0001485_abnormal_pinna_reflex1.21327197
69MP0003755_abnormal_palate_morphology1.20903016
70MP0009046_muscle_twitch1.18259253
71MP0010094_abnormal_chromosome_stability1.18169985
72MP0001984_abnormal_olfaction1.16729715
73MP0005171_absent_coat_pigmentation1.15664618
74MP0005535_abnormal_body_temperature1.15579534
75MP0003690_abnormal_glial_cell1.14640615
76MP0005248_abnormal_Harderian_gland1.14110246
77MP0003937_abnormal_limbs/digits/tail_de1.13980878
78MP0002272_abnormal_nervous_system1.12994364
79MP0002752_abnormal_somatic_nervous1.11769068
80MP0000604_amyloidosis1.10614197
81MP0001963_abnormal_hearing_physiology1.10299140
82MP0000516_abnormal_urinary_system1.09599119
83MP0005367_renal/urinary_system_phenotyp1.09599119
84MP0002751_abnormal_autonomic_nervous1.08789288
85MP0009697_abnormal_copulation1.08690696
86MP0002882_abnormal_neuron_morphology1.08284171
87MP0000647_abnormal_sebaceous_gland1.06771172
88MP0001986_abnormal_taste_sensitivity1.06475037
89MP0002736_abnormal_nociception_after1.05632765
90MP0001501_abnormal_sleep_pattern1.03987723
91MP0002837_dystrophic_cardiac_calcinosis1.03367276
92MP0005195_abnormal_posterior_eye1.02977655
93MP0005084_abnormal_gallbladder_morpholo1.01400404
94MP0002160_abnormal_reproductive_system1.00453955
95MP0003011_delayed_dark_adaptation0.99202411
96MP0003646_muscle_fatigue0.98143587
97MP0002734_abnormal_mechanical_nocicepti0.97990100
98MP0004147_increased_porphyrin_level0.97619868
99MP0001502_abnormal_circadian_rhythm0.97406389
100MP0003861_abnormal_nervous_system0.96411206
101MP0003879_abnormal_hair_cell0.96151570
102MP0004130_abnormal_muscle_cell0.96143033
103MP0009643_abnormal_urine_homeostasis0.95840987
104MP0002282_abnormal_trachea_morphology0.95147291
105MP0004145_abnormal_muscle_electrophysio0.94439233
106MP0002095_abnormal_skin_pigmentation0.94437745
107MP0002152_abnormal_brain_morphology0.93691995
108MP0005451_abnormal_body_composition0.93151660
109MP0001440_abnormal_grooming_behavior0.92381225
110MP0005391_vision/eye_phenotype0.92295979
111MP0002067_abnormal_sensory_capabilities0.91636253
112MP0005551_abnormal_eye_electrophysiolog0.91315998
113MP0005636_abnormal_mineral_homeostasis0.89323097
114MP0002735_abnormal_chemical_nociception0.89298643
115MP0008872_abnormal_physiological_respon0.87301219
116MP0005423_abnormal_somatic_nervous0.86959373
117MP0004924_abnormal_behavior0.86780621
118MP0005386_behavior/neurological_phenoty0.86780621
119MP0010030_abnormal_orbit_morphology0.86056226
120MP0008932_abnormal_embryonic_tissue0.85908085
121MP0005647_abnormal_sex_gland0.85580540
122MP0003938_abnormal_ear_development0.85501879
123MP0001286_abnormal_eye_development0.85105269
124* MP0003633_abnormal_nervous_system0.84632744
125MP0005187_abnormal_penis_morphology0.84486976
126* MP0008874_decreased_physiological_sensi0.84010301
127MP0006276_abnormal_autonomic_nervous0.82746524
128MP0009250_abnormal_appendicular_skeleto0.82701401
129MP0005379_endocrine/exocrine_gland_phen0.80730579
130MP0003119_abnormal_digestive_system0.79996556
131MP0001188_hyperpigmentation0.79534772
132MP0002078_abnormal_glucose_homeostasis0.78680960
133MP0003137_abnormal_impulse_conducting0.78449001
134MP0005389_reproductive_system_phenotype0.77867457
135MP0004885_abnormal_endolymph0.75111952
136MP0002069_abnormal_eating/drinking_beha0.72872382
137MP0002909_abnormal_adrenal_gland0.72789839
138MP0004142_abnormal_muscle_tone0.71556386
139* MP0002557_abnormal_social/conspecific_i0.70482540
140MP0009764_decreased_sensitivity_to0.68183218
141MP0001765_abnormal_ion_homeostasis0.67551735
142MP0002733_abnormal_thermal_nociception0.67200823
143MP0002090_abnormal_vision0.67176689
144MP0009642_abnormal_blood_homeostasis0.66914241
145* MP0003631_nervous_system_phenotype0.66903519
146MP0002066_abnormal_motor_capabilities/c0.65766789
147MP0000778_abnormal_nervous_system0.65725549
148MP0005448_abnormal_energy_balance0.65603975
149MP0003075_altered_response_to0.64398574
150MP0001756_abnormal_urination0.62933009
151MP0000639_abnormal_adrenal_gland0.62885164
152MP0001905_abnormal_dopamine_level0.62615870
153MP0006036_abnormal_mitochondrial_physio0.61139471
154MP0001177_atelectasis0.60958163
155MP0000230_abnormal_systemic_arterial0.60389847
156MP0005334_abnormal_fat_pad0.59596166
157MP0003953_abnormal_hormone_level0.58506292
158MP0003186_abnormal_redox_activity0.58476357
159* MP0002229_neurodegeneration0.58000029
160MP0003656_abnormal_erythrocyte_physiolo0.55221790
161MP0006035_abnormal_mitochondrial_morpho0.54791777
162MP0008569_lethality_at_weaning0.54527039
163MP0001970_abnormal_pain_threshold0.54265396
164* MP0004811_abnormal_neuron_physiology0.53226906

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.90354470
2Intrahepatic cholestasis (HP:0001406)5.80886584
3Deep venous thrombosis (HP:0002625)5.66806907
4Prolonged partial thromboplastin time (HP:0003645)5.02196513
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.95465241
6Xanthomatosis (HP:0000991)4.82802793
7Hypobetalipoproteinemia (HP:0003563)4.66734455
8Hyperlipoproteinemia (HP:0010980)4.44627674
9Hyperventilation (HP:0002883)4.21709247
10Hyperglycinemia (HP:0002154)4.13057182
11Complement deficiency (HP:0004431)4.10537957
12Ketosis (HP:0001946)3.98720461
13Conjugated hyperbilirubinemia (HP:0002908)3.97891590
14Epidermoid cyst (HP:0200040)3.89057751
15Hyperammonemia (HP:0001987)3.87629839
16Acute necrotizing encephalopathy (HP:0006965)3.73563009
17Hyperglycinuria (HP:0003108)3.72804668
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.69883667
19Abnormality of serine family amino acid metabolism (HP:0010894)3.68359964
20Abnormality of glycine metabolism (HP:0010895)3.68359964
21Molar tooth sign on MRI (HP:0002419)3.56075363
22Abnormality of midbrain morphology (HP:0002418)3.56075363
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.52481835
24Gait imbalance (HP:0002141)3.49559136
25Joint hemorrhage (HP:0005261)3.48340534
26Hypolipoproteinemia (HP:0010981)3.48111301
27Medial flaring of the eyebrow (HP:0010747)3.48105688
28True hermaphroditism (HP:0010459)3.47132508
29Focal motor seizures (HP:0011153)3.40365276
30Acute encephalopathy (HP:0006846)3.38707425
31Pancreatic cysts (HP:0001737)3.37228246
32Mitochondrial inheritance (HP:0001427)3.35989287
33Abnormality of sulfur amino acid metabolism (HP:0004339)3.33812536
34Abnormal mitochondria in muscle tissue (HP:0008316)3.31439099
35Fat malabsorption (HP:0002630)3.29535868
36Abnormality of methionine metabolism (HP:0010901)3.26275248
37Ketoacidosis (HP:0001993)3.22567034
38Pancreatic fibrosis (HP:0100732)3.21937637
39Congenital primary aphakia (HP:0007707)3.20570352
40Hepatocellular necrosis (HP:0001404)3.15230123
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.13157676
42Hypoalphalipoproteinemia (HP:0003233)3.10618174
43Progressive macrocephaly (HP:0004481)3.08511848
44Delayed CNS myelination (HP:0002188)3.07514571
45Abnormality of the common coagulation pathway (HP:0010990)3.06121416
46Nephronophthisis (HP:0000090)3.04795154
47Increased CSF lactate (HP:0002490)3.04141630
48Gout (HP:0001997)3.03545897
49Hepatic necrosis (HP:0002605)2.96755630
50Nephrogenic diabetes insipidus (HP:0009806)2.95904882
51Colon cancer (HP:0003003)2.87507341
52Hypoglycemic coma (HP:0001325)2.86125176
53Abnormality of fatty-acid metabolism (HP:0004359)2.84774332
54Retinal dysplasia (HP:0007973)2.84540436
55Abnormality of the labia minora (HP:0012880)2.79690681
56Myokymia (HP:0002411)2.76934148
57Abnormality of serum amino acid levels (HP:0003112)2.76695666
58Metabolic acidosis (HP:0001942)2.75580381
59Hyperbilirubinemia (HP:0002904)2.72889597
60Increased hepatocellular lipid droplets (HP:0006565)2.68390618
61Abnormality of complement system (HP:0005339)2.67541579
62Abnormality of pyrimidine metabolism (HP:0004353)2.66934092
63Renal Fanconi syndrome (HP:0001994)2.64547893
64Hypercholesterolemia (HP:0003124)2.64147245
65Status epilepticus (HP:0002133)2.61756425
66Genital tract atresia (HP:0001827)2.61706270
67Sclerocornea (HP:0000647)2.61616767
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.60261704
69Vaginal atresia (HP:0000148)2.58380601
70Lipid accumulation in hepatocytes (HP:0006561)2.56938641
71Abnormality of nucleobase metabolism (HP:0010932)2.55772930
72Abnormality of purine metabolism (HP:0004352)2.50192349
73Sensorimotor neuropathy (HP:0007141)2.46310827
74Abnormality of the intrinsic pathway (HP:0010989)2.46129875
75Spontaneous abortion (HP:0005268)2.45781348
76Epileptic encephalopathy (HP:0200134)2.42704090
77Steatorrhea (HP:0002570)2.41096303
78Polyphagia (HP:0002591)2.38086034
79Lethargy (HP:0001254)2.36616076
80Skin nodule (HP:0200036)2.35771010
81Chronic hepatic failure (HP:0100626)2.34653270
82Abnormality of the renal medulla (HP:0100957)2.33964853
83Methylmalonic acidemia (HP:0002912)2.30605232
84Mitral stenosis (HP:0001718)2.26083605
85Neonatal onset (HP:0003623)2.24743217
86Alkalosis (HP:0001948)2.23966640
87Focal seizures (HP:0007359)2.23206444
88Broad foot (HP:0001769)2.22692169
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.22565928
90Irritability (HP:0000737)2.20319867
91Cerebral edema (HP:0002181)2.18828289
92Torticollis (HP:0000473)2.17929480
93Abnormal gallbladder physiology (HP:0012438)2.17819976
94Cholecystitis (HP:0001082)2.17819976
95Dicarboxylic aciduria (HP:0003215)2.17603552
96Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17603552
97Vascular calcification (HP:0004934)2.17458307
98Neurofibrillary tangles (HP:0002185)2.17418495
99Fair hair (HP:0002286)2.13281911
100Optic disc pallor (HP:0000543)2.12810057
101Postaxial hand polydactyly (HP:0001162)2.12778320
102Focal dystonia (HP:0004373)2.12622603
103Lissencephaly (HP:0001339)2.12473728
104Postaxial foot polydactyly (HP:0001830)2.11963089
105Oligodactyly (hands) (HP:0001180)2.10921323
106Hepatocellular carcinoma (HP:0001402)2.10225939
107Hypochromic microcytic anemia (HP:0004840)2.09617288
108Abnormal gallbladder morphology (HP:0012437)2.08266270
109Craniofacial dystonia (HP:0012179)2.08242056
110Vomiting (HP:0002013)2.06760162
111Lactic acidosis (HP:0003128)2.06497686
112Methylmalonic aciduria (HP:0012120)2.04259505
113Limb dystonia (HP:0002451)2.03051142
114Increased serum lactate (HP:0002151)2.02890080
115Enlarged kidneys (HP:0000105)2.01847882
116Epileptiform EEG discharges (HP:0011182)2.01641384
117Cholelithiasis (HP:0001081)2.01176708
118Hypophosphatemic rickets (HP:0004912)1.99433606
119Hypoglycemic seizures (HP:0002173)1.99082354
120Intestinal atresia (HP:0011100)1.98842972
121Pachygyria (HP:0001302)1.98569998
122Occipital encephalocele (HP:0002085)1.98420107
123Poor suck (HP:0002033)1.97836894
124Bifid tongue (HP:0010297)1.97661471
125Broad-based gait (HP:0002136)1.97115255
126Generalized tonic-clonic seizures (HP:0002069)1.96590028
127Poor coordination (HP:0002370)1.95651844
128Narrow forehead (HP:0000341)1.95122844
129Increased purine levels (HP:0004368)1.95115356
130Hyperuricemia (HP:0002149)1.95115356
131Anencephaly (HP:0002323)1.94498499
132Abnormal respiratory motile cilium physiology (HP:0012261)1.94308600
133Increased serum pyruvate (HP:0003542)1.94171073
134Rickets (HP:0002748)1.93835637
135Cerebral inclusion bodies (HP:0100314)1.93199132
136EEG with generalized epileptiform discharges (HP:0011198)1.92115806
137Acanthocytosis (HP:0001927)1.92076738
138Abnormal ciliary motility (HP:0012262)1.91530003
1393-Methylglutaconic aciduria (HP:0003535)1.91029515
140Aplasia/Hypoplasia of the lens (HP:0008063)1.90892024
141Confusion (HP:0001289)1.89875113
142Pendular nystagmus (HP:0012043)1.89606012
143Proximal tubulopathy (HP:0000114)1.89256142
144Hypsarrhythmia (HP:0002521)1.88261816
145Specific learning disability (HP:0001328)1.86731095
146Cardiovascular calcification (HP:0011915)1.86691568
147Ependymoma (HP:0002888)1.84481930
148Progressive cerebellar ataxia (HP:0002073)1.83904331
149Preaxial hand polydactyly (HP:0001177)1.83044963
150Systemic lupus erythematosus (HP:0002725)1.82994239
151Hemiparesis (HP:0001269)1.82938548
152Respiratory failure (HP:0002878)1.81581857
153Abnormal social behavior (HP:0012433)1.80813330
154Impaired social interactions (HP:0000735)1.80813330
155Brushfield spots (HP:0001088)1.80711739
156Cystic liver disease (HP:0006706)1.80463203
157Generalized aminoaciduria (HP:0002909)1.80039673
158Anophthalmia (HP:0000528)1.80010684
159Abnormality of the gallbladder (HP:0005264)1.79667478
160Optic nerve hypoplasia (HP:0000609)1.79582133
161Impaired vibration sensation in the lower limbs (HP:0002166)1.78989408
162Blue irides (HP:0000635)1.78902642
163Aganglionic megacolon (HP:0002251)1.77794914
164Pheochromocytoma (HP:0002666)1.77175381
165Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77032184
166Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77032184
167Gastrointestinal atresia (HP:0002589)1.76668536
168Malnutrition (HP:0004395)1.76611572
169Amyotrophic lateral sclerosis (HP:0007354)1.76347647
170Absence seizures (HP:0002121)1.75408752
171Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.74660168
172Hypothermia (HP:0002045)1.74116583
173Abnormality of the astrocytes (HP:0100707)1.73262438
174Astrocytoma (HP:0009592)1.73262438
175Increased intramyocellular lipid droplets (HP:0012240)1.72374007
176Decreased testicular size (HP:0008734)1.70711003
177X-linked dominant inheritance (HP:0001423)1.69851372
178Septo-optic dysplasia (HP:0100842)1.68362691
179Aplasia/Hypoplasia of the tibia (HP:0005772)1.68351885
180Medulloblastoma (HP:0002885)1.67626545
181Drooling (HP:0002307)1.67597932
182Glycosuria (HP:0003076)1.67283915
183Abnormality of urine glucose concentration (HP:0011016)1.67283915
184Abnormality of renal resorption (HP:0011038)1.66237312
185Short tibia (HP:0005736)1.66074780
186Abnormal respiratory epithelium morphology (HP:0012253)1.66073226
187Abnormal respiratory motile cilium morphology (HP:0005938)1.66073226
188Type II lissencephaly (HP:0007260)1.65963534
189Exertional dyspnea (HP:0002875)1.64381227
190Abnormality of glycolysis (HP:0004366)1.63849587
191Abnormality of the renal cortex (HP:0011035)1.63186791
192Oligodactyly (HP:0012165)1.62822254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.34429671
2CASK3.35371830
3PRPF4B3.22842904
4NTRK32.99021543
5BCKDK2.91699391
6DAPK22.82373549
7MAP2K72.65226450
8BCR2.56751493
9MAP3K42.54909734
10MAP2K42.41920678
11MARK12.33530658
12MAP4K22.23961142
13INSRR2.23182359
14DYRK22.14902440
15TRIM282.01458486
16STK161.84163304
17SGK21.82139496
18SGK2231.81069403
19SGK4941.81069403
20OXSR11.80425547
21EPHB21.79417630
22EIF2AK31.78903858
23MINK11.76166952
24MAP3K91.71734003
25CSNK1G31.64866422
26NEK11.60296068
27PDK21.58229565
28PNCK1.55805184
29LIMK11.51938295
30CSNK1A1L1.49586489
31PINK11.48187132
32SGK31.46891977
33CSNK1G11.44681163
34BMPR1B1.37322922
35VRK21.36722904
36PAK61.36582498
37SIK11.33347711
38SRPK11.28567860
39ERBB31.27717063
40DAPK11.26911714
41WEE11.22497166
42LATS11.22104745
43CAMKK11.22102469
44PRKCG1.18617313
45NME11.16140790
46PIK3CA1.15998196
47FGFR41.13267589
48KSR11.13266024
49WNK31.09645879
50TNIK1.09622288
51MAP3K121.08827664
52VRK11.08409390
53NTRK21.07956158
54ADRBK21.07417234
55GRK11.06694815
56CDK51.03850989
57MAP3K71.02814910
58ZAK1.02541222
59CAMK2A1.01690605
60KSR21.01178578
61CDK191.01089668
62PTK2B1.00393515
63STK380.99812872
64NUAK10.99397787
65CDC70.99060793
66WNK40.98027294
67PLK20.96157548
68FRK0.95018692
69MAPK130.93192238
70MAP3K130.91355271
71PLK30.91265638
72TLK10.91200818
73ERBB40.90441781
74BUB10.90339147
75PAK30.88979238
76DYRK30.88400383
77SIK30.86998818
78MAP3K50.86845820
79NTRK10.86800881
80PRKCZ0.86775387
81TAOK20.86252687
82BMPR20.86166460
83AKT30.84023601
84PRKD30.82765983
85PHKG20.81863077
86PHKG10.81863077
87PLK40.81755221
88CAMK2B0.80224680
89CAMK2G0.78138899
90PLK10.77322515
91CAMK40.76812089
92GRK50.76148561
93MAPK120.73969378
94SGK10.73087068
95CAMK10.73083978
96PDPK10.72724980
97TTK0.72302056
98RPS6KA40.70815713
99MAP3K20.70550992
100MAPK110.69058771
101ARAF0.69053538
102PBK0.68322177
103ATR0.67638904
104UHMK10.67638675
105CDK140.65605434
106EIF2AK10.65577518
107PKN10.65220288
108PRKCH0.65114538
109FGFR20.62617269
110CDK80.61991689
111RIPK40.61321392
112FER0.59798715
113TAOK30.59334518
114MAP2K60.58556913
115OBSCN0.57211040
116CHEK20.56919205
117PDK10.56745602
118CSNK1G20.56348172
119DYRK1A0.55283691
120PRKCE0.55148721
121CAMKK20.54590908
122SIK20.54453737
123MAP2K10.54379168
124EIF2AK20.53157972
125STK110.52657977
126MUSK0.51446216
127RET0.51299571
128IRAK20.51208630
129MAPK70.51064836
130ERBB20.50606672
131PRKACG0.50027731
132ABL20.49834791
133FES0.49793901
134STK390.49547798
135CCNB10.48309739
136CSNK1A10.48256042
137CDK150.46072611
138MAPK150.45987928
139LATS20.45857254
140CDK11A0.45154098
141PRKAA20.43513053
142TSSK60.43148213
143CAMK2D0.41774767
144PRKAA10.41613900
145CSNK1D0.40531577
146CDK30.40530228
147STK38L0.40509256
148MAP3K10.40257827
149EPHA30.40032538
150RPS6KA30.39117429
151ATM0.38843957
152MARK20.38614098
153CAMK1G0.38345271
154CSNK2A10.37688627
155PRKACA0.37234248
156CDK180.36927790
157PRKCA0.36754578

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.95688383
2Nitrogen metabolism_Homo sapiens_hsa009103.50718160
3Oxidative phosphorylation_Homo sapiens_hsa001903.49900944
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08662822
5Parkinsons disease_Homo sapiens_hsa050123.03044827
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92654401
7Protein export_Homo sapiens_hsa030602.71512349
8Arginine biosynthesis_Homo sapiens_hsa002202.70321111
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57027876
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.55659483
11Butanoate metabolism_Homo sapiens_hsa006502.47485067
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38714907
13Tryptophan metabolism_Homo sapiens_hsa003802.35085996
14Fatty acid degradation_Homo sapiens_hsa000712.21588511
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20444544
16Huntingtons disease_Homo sapiens_hsa050162.17992860
17Mismatch repair_Homo sapiens_hsa034302.15233331
18Proteasome_Homo sapiens_hsa030502.10070846
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08925750
20Fanconi anemia pathway_Homo sapiens_hsa034602.07952261
21Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02038312
22Alzheimers disease_Homo sapiens_hsa050101.99524364
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98788394
24Propanoate metabolism_Homo sapiens_hsa006401.97179791
25Complement and coagulation cascades_Homo sapiens_hsa046101.95869637
26* Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90466273
27Peroxisome_Homo sapiens_hsa041461.89753356
28RNA polymerase_Homo sapiens_hsa030201.83111656
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.78134863
30Basal transcription factors_Homo sapiens_hsa030221.78065092
31Homologous recombination_Homo sapiens_hsa034401.78004664
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74906510
33Cardiac muscle contraction_Homo sapiens_hsa042601.74025846
34Chemical carcinogenesis_Homo sapiens_hsa052041.73783267
35Fatty acid metabolism_Homo sapiens_hsa012121.69290488
36PPAR signaling pathway_Homo sapiens_hsa033201.63173045
37Bile secretion_Homo sapiens_hsa049761.61823860
38beta-Alanine metabolism_Homo sapiens_hsa004101.59544742
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57259272
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51767888
41Histidine metabolism_Homo sapiens_hsa003401.51472606
42Ribosome_Homo sapiens_hsa030101.48968284
43Nucleotide excision repair_Homo sapiens_hsa034201.48516248
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46769406
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43034469
46Sulfur metabolism_Homo sapiens_hsa009201.41815227
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41035952
48Retinol metabolism_Homo sapiens_hsa008301.38756400
49DNA replication_Homo sapiens_hsa030301.38392518
50Pyruvate metabolism_Homo sapiens_hsa006201.35869098
51Non-homologous end-joining_Homo sapiens_hsa034501.32093124
52RNA degradation_Homo sapiens_hsa030181.24138536
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22371511
54Phenylalanine metabolism_Homo sapiens_hsa003601.22181042
55Caffeine metabolism_Homo sapiens_hsa002321.19357565
56Fatty acid elongation_Homo sapiens_hsa000621.18596051
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.17899660
58Starch and sucrose metabolism_Homo sapiens_hsa005001.14687191
59Nicotine addiction_Homo sapiens_hsa050331.14449578
60Pyrimidine metabolism_Homo sapiens_hsa002401.11229721
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08516473
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07436705
63Tyrosine metabolism_Homo sapiens_hsa003501.06780019
64Base excision repair_Homo sapiens_hsa034101.04884321
65Spliceosome_Homo sapiens_hsa030401.03289331
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03226049
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01114531
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.00936611
69RNA transport_Homo sapiens_hsa030130.99372070
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.95465168
71ABC transporters_Homo sapiens_hsa020100.94859546
72Staphylococcus aureus infection_Homo sapiens_hsa051500.91768127
73Carbon metabolism_Homo sapiens_hsa012000.90573414
74Synaptic vesicle cycle_Homo sapiens_hsa047210.88117804
75GABAergic synapse_Homo sapiens_hsa047270.84664417
76Purine metabolism_Homo sapiens_hsa002300.84648814
77Steroid biosynthesis_Homo sapiens_hsa001000.84007659
78Regulation of autophagy_Homo sapiens_hsa041400.83587701
79Biosynthesis of amino acids_Homo sapiens_hsa012300.83508704
80Selenocompound metabolism_Homo sapiens_hsa004500.81564508
81Arginine and proline metabolism_Homo sapiens_hsa003300.80261865
82Fat digestion and absorption_Homo sapiens_hsa049750.77014664
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75123241
84Vitamin digestion and absorption_Homo sapiens_hsa049770.74352525
85Vitamin B6 metabolism_Homo sapiens_hsa007500.73171225
86Oocyte meiosis_Homo sapiens_hsa041140.72697926
87One carbon pool by folate_Homo sapiens_hsa006700.72648592
88Glycerolipid metabolism_Homo sapiens_hsa005610.69395138
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69046130
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67319898
91Basal cell carcinoma_Homo sapiens_hsa052170.66742370
92Circadian entrainment_Homo sapiens_hsa047130.66643776
93Glutamatergic synapse_Homo sapiens_hsa047240.66607829
94Hedgehog signaling pathway_Homo sapiens_hsa043400.63088620
95Amphetamine addiction_Homo sapiens_hsa050310.62314167
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60218126
97Sulfur relay system_Homo sapiens_hsa041220.59877504
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.58993765
99Axon guidance_Homo sapiens_hsa043600.58688709
100Morphine addiction_Homo sapiens_hsa050320.58527488
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58385110
102Linoleic acid metabolism_Homo sapiens_hsa005910.56735380
103Lysine degradation_Homo sapiens_hsa003100.55719606
104Fatty acid biosynthesis_Homo sapiens_hsa000610.54420006
105Cell cycle_Homo sapiens_hsa041100.54223651
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53954413
107Olfactory transduction_Homo sapiens_hsa047400.53413709
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53164100
109Glutathione metabolism_Homo sapiens_hsa004800.52251470
110Insulin secretion_Homo sapiens_hsa049110.49439730
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49281031
112Ether lipid metabolism_Homo sapiens_hsa005650.48171166
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47302546
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47195026
115Folate biosynthesis_Homo sapiens_hsa007900.46813315
116Long-term potentiation_Homo sapiens_hsa047200.46487475
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45525297
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44309269
119Prion diseases_Homo sapiens_hsa050200.44096965
120Salivary secretion_Homo sapiens_hsa049700.43977869
121Collecting duct acid secretion_Homo sapiens_hsa049660.43112659
122Hippo signaling pathway_Homo sapiens_hsa043900.41451331
123Renin secretion_Homo sapiens_hsa049240.40497411
124Dopaminergic synapse_Homo sapiens_hsa047280.37752412
125Taste transduction_Homo sapiens_hsa047420.36867799
126Gastric acid secretion_Homo sapiens_hsa049710.34466238
127Glucagon signaling pathway_Homo sapiens_hsa049220.34210958
128Metabolic pathways_Homo sapiens_hsa011000.32925871
129Cocaine addiction_Homo sapiens_hsa050300.32841399
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28071562
131Cholinergic synapse_Homo sapiens_hsa047250.26861009
132Calcium signaling pathway_Homo sapiens_hsa040200.23827142
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21449759
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20359509
135Phototransduction_Homo sapiens_hsa047440.19787385
136Serotonergic synapse_Homo sapiens_hsa047260.18020610
137Type II diabetes mellitus_Homo sapiens_hsa049300.17631690
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.17100764
139cAMP signaling pathway_Homo sapiens_hsa040240.16562851
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16251827
141Thyroid hormone synthesis_Homo sapiens_hsa049180.15925065

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