SRRM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.40800210
2CENP-A containing nucleosome assembly (GO:0034080)4.34843109
3pre-miRNA processing (GO:0031054)4.25638371
4centriole replication (GO:0007099)4.20630077
5histone exchange (GO:0043486)4.07535578
6negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.07454488
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06651378
8translational termination (GO:0006415)3.86554758
9DNA unwinding involved in DNA replication (GO:0006268)3.83749931
10viral transcription (GO:0019083)3.83223328
11mRNA splice site selection (GO:0006376)3.82369326
12establishment of integrated proviral latency (GO:0075713)3.78951437
13negative regulation of mRNA processing (GO:0050686)3.77755333
14negative regulation of RNA splicing (GO:0033119)3.71756918
15kinetochore organization (GO:0051383)3.66730498
16regulation of centriole replication (GO:0046599)3.66508776
17nuclear pore complex assembly (GO:0051292)3.63065842
18histone H3-K4 trimethylation (GO:0080182)3.59962492
19ribosomal small subunit assembly (GO:0000028)3.56834464
20ribosomal large subunit biogenesis (GO:0042273)3.55698784
21ribosomal small subunit biogenesis (GO:0042274)3.51695517
22nuclear pore organization (GO:0006999)3.45918429
23alternative mRNA splicing, via spliceosome (GO:0000380)3.44953813
24histone H3-K4 methylation (GO:0051568)3.44673607
25negative regulation of mRNA metabolic process (GO:1903312)3.40467978
26DNA ligation (GO:0006266)3.40333672
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39809180
28cotranslational protein targeting to membrane (GO:0006613)3.37868163
29kinetochore assembly (GO:0051382)3.36402038
30ATP synthesis coupled proton transport (GO:0015986)3.35984254
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.35984254
32purine nucleobase biosynthetic process (GO:0009113)3.35057036
33protein targeting to ER (GO:0045047)3.31480351
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31235509
35regulation of mitotic spindle checkpoint (GO:1903504)3.31235509
36maturation of SSU-rRNA (GO:0030490)3.29677191
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29128402
38translational initiation (GO:0006413)3.28385373
39nucleobase biosynthetic process (GO:0046112)3.27376947
40rRNA modification (GO:0000154)3.25672318
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.25354021
42chromosome condensation (GO:0030261)3.20149757
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19859642
44negative regulation of histone methylation (GO:0031061)3.19416007
45protein localization to kinetochore (GO:0034501)3.19118417
46histone H4-K12 acetylation (GO:0043983)3.17594494
47regulation of DNA endoreduplication (GO:0032875)3.17194935
48replication fork processing (GO:0031297)3.16942622
49centriole assembly (GO:0098534)3.15155792
50heterochromatin organization (GO:0070828)3.13695113
51sister chromatid segregation (GO:0000819)3.12826314
52translational elongation (GO:0006414)3.12706194
53mitotic sister chromatid segregation (GO:0000070)3.11468390
54intra-S DNA damage checkpoint (GO:0031573)3.11134225
55regulation of RNA export from nucleus (GO:0046831)3.10414159
56DNA packaging (GO:0006323)3.09819507
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07957886
58regulation of histone H3-K4 methylation (GO:0051569)3.04991743
59cellular protein complex disassembly (GO:0043624)3.04437857
60protein localization to endoplasmic reticulum (GO:0070972)3.03892170
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03068622
62proteasome assembly (GO:0043248)3.01494503
63regulation of sister chromatid cohesion (GO:0007063)3.01110244
64peptidyl-lysine trimethylation (GO:0018023)3.00946411
65DNA double-strand break processing (GO:0000729)3.00773677
66mitotic G2/M transition checkpoint (GO:0044818)3.00181343
67* mRNA splicing, via spliceosome (GO:0000398)2.99868325
68* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.99868325
69DNA duplex unwinding (GO:0032508)2.99859208
70histone mRNA metabolic process (GO:0008334)2.98572389
71meiotic chromosome segregation (GO:0045132)2.98408955
72* RNA splicing, via transesterification reactions (GO:0000375)2.98071324
73DNA geometric change (GO:0032392)2.97540341
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.97121363
75rRNA methylation (GO:0031167)2.96998316
76telomere maintenance via telomerase (GO:0007004)2.96526891
77spliceosomal snRNP assembly (GO:0000387)2.96484159
78negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95601591
79negative regulation of mitotic sister chromatid separation (GO:2000816)2.95601591
80negative regulation of sister chromatid segregation (GO:0033046)2.95601591
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95601591
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95601591
83negative regulation of chromosome segregation (GO:0051985)2.94235844
84positive regulation of gene expression, epigenetic (GO:0045815)2.93662321
85ribonucleoprotein complex biogenesis (GO:0022613)2.93443412
86formation of translation preinitiation complex (GO:0001731)2.92981395
87histone H3-K9 methylation (GO:0051567)2.92859979
88spindle checkpoint (GO:0031577)2.91895798
89IMP biosynthetic process (GO:0006188)2.91435384
90rRNA processing (GO:0006364)2.91003542
91positive regulation of histone H3-K4 methylation (GO:0051571)2.90569387
92mitotic nuclear envelope disassembly (GO:0007077)2.90448291
93DNA topological change (GO:0006265)2.90156184
94protein complex disassembly (GO:0043241)2.88992904
95chaperone-mediated protein transport (GO:0072321)2.88349200
96paraxial mesoderm development (GO:0048339)2.87935623
97positive regulation of chromosome segregation (GO:0051984)2.86872362
98mitotic spindle checkpoint (GO:0071174)2.85598801
99regulation of centrosome cycle (GO:0046605)2.85580695
100DNA replication-dependent nucleosome assembly (GO:0006335)2.85035045
101DNA replication-dependent nucleosome organization (GO:0034723)2.85035045
102DNA replication initiation (GO:0006270)2.84829640
103sister chromatid cohesion (GO:0007062)2.84824454
104regulation of nuclear cell cycle DNA replication (GO:0033262)2.78187748
105pore complex assembly (GO:0046931)2.74274153
106mRNA stabilization (GO:0048255)2.73289894
107RNA stabilization (GO:0043489)2.73289894
108DNA strand elongation involved in DNA replication (GO:0006271)2.72917374
109histone lysine methylation (GO:0034968)2.72450538
110regulation of histone H3-K9 methylation (GO:0051570)2.71277172
111DNA replication checkpoint (GO:0000076)2.71169990
112protein localization to chromosome, centromeric region (GO:0071459)2.69000280
113metaphase plate congression (GO:0051310)2.67638936
114histone methylation (GO:0016571)2.66900629
115mitotic metaphase plate congression (GO:0007080)2.66394946
116protein-DNA complex disassembly (GO:0032986)2.65007788
117nucleosome disassembly (GO:0006337)2.65007788
118positive regulation of RNA splicing (GO:0033120)2.64618298
119ATP-dependent chromatin remodeling (GO:0043044)2.63589953
120nuclear envelope disassembly (GO:0051081)2.62420872
121membrane disassembly (GO:0030397)2.62420872
122DNA strand elongation (GO:0022616)2.62373040
123histone H2A acetylation (GO:0043968)2.62333735
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61530416
125negative regulation of DNA-dependent DNA replication (GO:2000104)2.61025932
126regulation of histone methylation (GO:0031060)2.59541211
127positive regulation of cell cycle G2/M phase transition (GO:1902751)2.59469780
128positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.59469780
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.57841643
130telomere maintenance via semi-conservative replication (GO:0032201)2.57637693
131regulation of mRNA splicing, via spliceosome (GO:0048024)2.56074128
132regulation of telomere maintenance via telomerase (GO:0032210)2.54909209
133glucocorticoid receptor signaling pathway (GO:0042921)2.54766956
134DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.53969091
135mitotic chromosome condensation (GO:0007076)2.53829573
136mitotic recombination (GO:0006312)2.53784935
137histone H3-K9 modification (GO:0061647)2.53057893
138positive regulation of mitotic sister chromatid separation (GO:1901970)2.51911740
139positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.51911740
140positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.51911740
141DNA replication-independent nucleosome organization (GO:0034724)2.50064025
142DNA replication-independent nucleosome assembly (GO:0006336)2.50064025
143positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.49987055
144histone H4-K8 acetylation (GO:0043982)2.49126977
145histone H4-K5 acetylation (GO:0043981)2.49126977
146spliceosomal complex assembly (GO:0000245)2.48580026
147regulation of RNA splicing (GO:0043484)2.47276109
148histone H4 acetylation (GO:0043967)2.47052483
149stress granule assembly (GO:0034063)2.45243858
150* termination of RNA polymerase II transcription (GO:0006369)2.45179928
151* RNA splicing (GO:0008380)2.45149275
152DNA conformation change (GO:0071103)2.44965899
153regulation of mRNA processing (GO:0050684)2.44621338
154nucleotide-excision repair, DNA gap filling (GO:0006297)2.44241965
155* mRNA export from nucleus (GO:0006406)2.44018058
156* RNA export from nucleus (GO:0006405)2.43619473
157regulation of DNA damage checkpoint (GO:2000001)2.43504172
158microtubule depolymerization (GO:0007019)2.41934009
159telomere maintenance via recombination (GO:0000722)2.41792291
160V(D)J recombination (GO:0033151)2.41783084
161histone H4-K16 acetylation (GO:0043984)2.41248942
162chromatin remodeling at centromere (GO:0031055)2.41071109
163mismatch repair (GO:0006298)2.40833527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.39361361
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10536353
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.05156012
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.40292464
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.35759865
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22420829
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.93383752
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.92116288
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91924889
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.76752264
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66539016
12MYC_22102868_ChIP-Seq_BL_Human2.64789970
13* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54371254
14CIITA_25753668_ChIP-Seq_RAJI_Human2.49084816
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36525521
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35832532
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.21872292
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.19574307
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03858379
20E2F7_22180533_ChIP-Seq_HELA_Human10.0653552
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.97368283
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89351787
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88743334
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87700132
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85952674
26MYC_18940864_ChIP-ChIP_HL60_Human1.81521489
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.77263007
28* XRN2_22483619_ChIP-Seq_HELA_Human1.76514762
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.74537001
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.74537001
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.74537001
32AR_21909140_ChIP-Seq_LNCAP_Human1.73175458
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72279154
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63245376
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55976954
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.55655089
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54537620
38DCP1A_22483619_ChIP-Seq_HELA_Human1.54149204
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51240247
40TTF2_22483619_ChIP-Seq_HELA_Human1.50633180
41VDR_22108803_ChIP-Seq_LS180_Human1.49816159
42VDR_21846776_ChIP-Seq_THP-1_Human1.49446569
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48398833
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48078542
45* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45947392
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45180997
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41959827
48* KDM5A_27292631_Chip-Seq_BREAST_Human1.40213271
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39880224
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39679419
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39336595
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38873361
53* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.38035795
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37737157
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37689638
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36217800
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36174340
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35807408
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35338054
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32738342
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31816554
62* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30866482
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28557995
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27108340
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.26453907
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26185466
67ZNF274_21170338_ChIP-Seq_K562_Hela1.22073807
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19855477
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.19536569
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.18588327
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.17150724
72* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14803172
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13075350
74TCF7_22412390_ChIP-Seq_EML_Mouse1.11606629
75ELK1_19687146_ChIP-ChIP_HELA_Human1.11261678
76NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.11046426
77SCL_19346495_ChIP-Seq_HPC-7_Human1.10834659
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10806173
79* FOXP3_21729870_ChIP-Seq_TREG_Human1.10738918
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.08107668
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07312116
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07100754
83SOX2_16153702_ChIP-ChIP_HESCs_Human1.06233143
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05983814
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05023547
86* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04090287
87* KDM2B_26808549_Chip-Seq_DND41_Human1.02857881
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01469839
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01043561
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.00911282
91TCF3_18692474_ChIP-Seq_MESCs_Mouse1.00053744
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98442582
93* VDR_23849224_ChIP-Seq_CD4+_Human0.98335325
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98116993
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96749231
96* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95268088
97TAF15_26573619_Chip-Seq_HEK293_Human0.94622002
98* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94439170
99EWS_26573619_Chip-Seq_HEK293_Human0.94259773
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93224088
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93165254
102* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93027511
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92988913
104IRF1_19129219_ChIP-ChIP_H3396_Human0.92905828
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92712300
106* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91788798
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88917742
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88720823
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87785894
110ISL1_27105846_Chip-Seq_CPCs_Mouse0.87116512
111CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86923047
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86846006
113* CHD1_26751641_Chip-Seq_LNCaP_Human0.86269778
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86041918
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.85646030
116UTX_26944678_Chip-Seq_JUKART_Human0.85449539
117* KDM2B_26808549_Chip-Seq_JURKAT_Human0.84487534
118* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.83510169
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81332701
120FUS_26573619_Chip-Seq_HEK293_Human0.81090143
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80633695
122ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80585392
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79182506
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79182506
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78090521
126* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76198448
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.76057746
128* GABP_19822575_ChIP-Seq_HepG2_Human0.75767619
129* P300_19829295_ChIP-Seq_ESCs_Human0.75229048
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75051623
131CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74656137
132* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74623566
133TFEB_21752829_ChIP-Seq_HELA_Human0.74043251
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73850115
135* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.72325613
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71677975
137ELK1_22589737_ChIP-Seq_MCF10A_Human0.68504541
138* RBPJ_21746931_ChIP-Seq_IB4_Human0.67324736
139* ETV1_20927104_ChIP-Seq_GIST48_Human0.66955488
140* SOX17_20123909_ChIP-Seq_XEN_Mouse0.65673113
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65555375
142ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64605744
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.62999921
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62929738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.99043046
2MP0010094_abnormal_chromosome_stability3.00038175
3MP0003111_abnormal_nucleus_morphology2.95806698
4MP0003693_abnormal_embryo_hatching2.78103033
5MP0003077_abnormal_cell_cycle2.66307805
6MP0004957_abnormal_blastocyst_morpholog2.55840934
7MP0003121_genomic_imprinting2.38860394
8MP0003787_abnormal_imprinting2.21388726
9MP0009379_abnormal_foot_pigmentation2.16476227
10MP0003718_maternal_effect2.13710074
11MP0008877_abnormal_DNA_methylation2.13043710
12MP0008058_abnormal_DNA_repair2.02705516
13MP0003123_paternal_imprinting1.98060870
14MP0002396_abnormal_hematopoietic_system1.87102438
15MP0003122_maternal_imprinting1.84121804
16MP0009697_abnormal_copulation1.82762365
17MP0000566_synostosis1.82335092
18MP0008007_abnormal_cellular_replicative1.81230595
19MP0003890_abnormal_embryonic-extraembry1.80904037
20MP0000537_abnormal_urethra_morphology1.79960686
21MP0008932_abnormal_embryonic_tissue1.77411104
22MP0002653_abnormal_ependyma_morphology1.76393713
23MP0005076_abnormal_cell_differentiation1.75281674
24MP0000350_abnormal_cell_proliferation1.73388180
25MP0002084_abnormal_developmental_patter1.68415412
26MP0001730_embryonic_growth_arrest1.65705144
27MP0006292_abnormal_olfactory_placode1.63118751
28MP0002085_abnormal_embryonic_tissue1.61441903
29MP0005380_embryogenesis_phenotype1.49760806
30MP0001672_abnormal_embryogenesis/_devel1.49760806
31MP0004197_abnormal_fetal_growth/weight/1.47405475
32MP0001697_abnormal_embryo_size1.45428380
33MP0001929_abnormal_gametogenesis1.44764763
34MP0010030_abnormal_orbit_morphology1.42805307
35MP0003984_embryonic_growth_retardation1.40364054
36MP0002088_abnormal_embryonic_growth/wei1.36621067
37MP0004808_abnormal_hematopoietic_stem1.35693754
38MP0001188_hyperpigmentation1.35345714
39MP0003119_abnormal_digestive_system1.29222083
40MP0001293_anophthalmia1.28796633
41MP0000569_abnormal_digit_pigmentation1.26475592
42MP0003937_abnormal_limbs/digits/tail_de1.26439542
43MP0003698_abnormal_male_reproductive1.26436136
44MP0003136_yellow_coat_color1.24085187
45MP0004133_heterotaxia1.23051858
46MP0010352_gastrointestinal_tract_polyps1.22429654
47MP0002938_white_spotting1.22324004
48MP0001529_abnormal_vocalization1.22184921
49MP0002086_abnormal_extraembryonic_tissu1.18806961
50MP0005410_abnormal_fertilization1.18420458
51MP0000428_abnormal_craniofacial_morphol1.18111158
52MP0003861_abnormal_nervous_system1.17054363
53MP0000049_abnormal_middle_ear1.16825622
54MP0000703_abnormal_thymus_morphology1.16224505
55MP0009278_abnormal_bone_marrow1.14922664
56MP0002080_prenatal_lethality1.13739120
57MP0010307_abnormal_tumor_latency1.13342344
58MP0003935_abnormal_craniofacial_develop1.12474998
59MP0008789_abnormal_olfactory_epithelium1.10938771
60MP0003941_abnormal_skin_development1.10856773
61MP0000653_abnormal_sex_gland1.10377690
62MP0006072_abnormal_retinal_apoptosis1.09945886
63MP0005409_darkened_coat_color1.09878949
64MP0008995_early_reproductive_senescence1.08167322
65MP0003385_abnormal_body_wall1.08152949
66MP0009703_decreased_birth_body1.07080087
67MP0000432_abnormal_head_morphology1.06517130
68MP0003755_abnormal_palate_morphology1.05788848
69MP0002233_abnormal_nose_morphology1.05700898
70MP0000733_abnormal_muscle_development1.05283038
71MP0003283_abnormal_digestive_organ1.02527728
72MP0003786_premature_aging1.02203489
73MP0003567_abnormal_fetal_cardiomyocyte1.01143575
74MP0001286_abnormal_eye_development1.00450157
75MP0003938_abnormal_ear_development1.00433104
76MP0002638_abnormal_pupillary_reflex1.00124480
77MP0002116_abnormal_craniofacial_bone0.99884517
78MP0005377_hearing/vestibular/ear_phenot0.99481579
79MP0003878_abnormal_ear_physiology0.99481579
80MP0000313_abnormal_cell_death0.97320192
81MP0002102_abnormal_ear_morphology0.95882895
82MP0003315_abnormal_perineum_morphology0.95581337
83MP0000462_abnormal_digestive_system0.95424331
84MP0000383_abnormal_hair_follicle0.94781507
85MP0001984_abnormal_olfaction0.94534276
86MP0008961_abnormal_basal_metabolism0.93818943
87MP0003115_abnormal_respiratory_system0.93106983
88MP0002925_abnormal_cardiovascular_devel0.92416307
89MP0000372_irregular_coat_pigmentation0.91158126
90MP0005174_abnormal_tail_pigmentation0.90217433
91MP0000490_abnormal_crypts_of0.90185283
92MP0005499_abnormal_olfactory_system0.88384375
93MP0005394_taste/olfaction_phenotype0.88384375
94MP0006036_abnormal_mitochondrial_physio0.84991096
95MP0002249_abnormal_larynx_morphology0.84695519
96MP0002114_abnormal_axial_skeleton0.84486816
97MP0006035_abnormal_mitochondrial_morpho0.82133743
98MP0002697_abnormal_eye_size0.82130488
99MP0002932_abnormal_joint_morphology0.81838432
100MP0001346_abnormal_lacrimal_gland0.81399578
101MP0009672_abnormal_birth_weight0.80376006
102MP0002161_abnormal_fertility/fecundity0.79921492
103MP0002111_abnormal_tail_morphology0.77444312
104MP0005253_abnormal_eye_physiology0.76639434
105MP0003763_abnormal_thymus_physiology0.76538162
106MP0009053_abnormal_anal_canal0.75638698
107MP0002210_abnormal_sex_determination0.74508858
108MP0002751_abnormal_autonomic_nervous0.73785773
109MP0002081_perinatal_lethality0.71497322
110MP0010678_abnormal_skin_adnexa0.71081367
111MP0001849_ear_inflammation0.70611993
112MP0001485_abnormal_pinna_reflex0.70050388
113MP0002092_abnormal_eye_morphology0.68151260
114MP0001784_abnormal_fluid_regulation0.68099336
115MP0002009_preneoplasia0.68051819
116MP0001145_abnormal_male_reproductive0.67249182
117MP0000631_abnormal_neuroendocrine_gland0.66779494
118MP0001119_abnormal_female_reproductive0.66135500
119MP0002177_abnormal_outer_ear0.65733334
120MP0002398_abnormal_bone_marrow0.65586194
121MP0004264_abnormal_extraembryonic_tissu0.64087729
122MP0002160_abnormal_reproductive_system0.63192406
123MP0002234_abnormal_pharynx_morphology0.62942208
124MP0004885_abnormal_endolymph0.62785032
125MP0000647_abnormal_sebaceous_gland0.62554509
126MP0000778_abnormal_nervous_system0.62169764
127MP0005391_vision/eye_phenotype0.61777652
128MP0002095_abnormal_skin_pigmentation0.61620592
129MP0005551_abnormal_eye_electrophysiolog0.61048087
130MP0005623_abnormal_meninges_morphology0.61038788
131MP0002109_abnormal_limb_morphology0.60074924
132MP0003936_abnormal_reproductive_system0.59345673
133MP0009046_muscle_twitch0.58723109

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.04322119
2Abnormal number of incisors (HP:0011064)3.32452766
3Abnormality of cells of the erythroid lineage (HP:0012130)3.14317745
4Chromsome breakage (HP:0040012)3.05381672
5Medulloblastoma (HP:0002885)3.04422982
6Acute necrotizing encephalopathy (HP:0006965)3.01021953
7Abnormality of the fingertips (HP:0001211)2.96109776
8Macrocytic anemia (HP:0001972)2.90071061
9Abnormality of the labia minora (HP:0012880)2.89643149
10Abnormal number of erythroid precursors (HP:0012131)2.88869717
11Supernumerary ribs (HP:0005815)2.85598752
12Increased nuchal translucency (HP:0010880)2.82425036
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.80771469
14Anal stenosis (HP:0002025)2.77631930
15Long eyelashes (HP:0000527)2.76873366
16Supernumerary bones of the axial skeleton (HP:0009144)2.70531522
17Ectopic kidney (HP:0000086)2.68273942
18Acute encephalopathy (HP:0006846)2.66599715
19Increased hepatocellular lipid droplets (HP:0006565)2.65528973
20Ependymoma (HP:0002888)2.64296148
21Proximal placement of thumb (HP:0009623)2.64245263
22Neoplasm of the oral cavity (HP:0100649)2.62501276
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59523508
24Short 4th metacarpal (HP:0010044)2.59523508
25Abnormal mitochondria in muscle tissue (HP:0008316)2.57041930
26Selective tooth agenesis (HP:0001592)2.53389610
27Abnormality of homocysteine metabolism (HP:0010919)2.52102296
28Homocystinuria (HP:0002156)2.52102296
29Deviation of the thumb (HP:0009603)2.47598948
30Trigonocephaly (HP:0000243)2.46764904
31Triphalangeal thumb (HP:0001199)2.41575300
32Progressive macrocephaly (HP:0004481)2.41335262
33Abnormal lung lobation (HP:0002101)2.38178832
34Mitochondrial inheritance (HP:0001427)2.35684797
35Lipid accumulation in hepatocytes (HP:0006561)2.34031067
36Septo-optic dysplasia (HP:0100842)2.29648911
37Increased CSF lactate (HP:0002490)2.29491384
38Absent thumb (HP:0009777)2.27449082
39Sloping forehead (HP:0000340)2.26241401
40Patellar aplasia (HP:0006443)2.26102488
41Acute lymphatic leukemia (HP:0006721)2.25809792
42Absent radius (HP:0003974)2.22597668
43Abnormality of the parietal bone (HP:0002696)2.21911401
44Birth length less than 3rd percentile (HP:0003561)2.21723209
45Rib fusion (HP:0000902)2.20069593
46Abnormality of chromosome segregation (HP:0002916)2.19963892
47Urethral obstruction (HP:0000796)2.16600682
48Absent forearm bone (HP:0003953)2.13642911
49Aplasia involving forearm bones (HP:0009822)2.13642911
50Esophageal atresia (HP:0002032)2.11905617
51Pallor (HP:0000980)2.11385593
52Abnormality of the astrocytes (HP:0100707)2.09305842
53Astrocytoma (HP:0009592)2.09305842
54Bilateral microphthalmos (HP:0007633)2.09291343
55Aplasia/Hypoplasia of the patella (HP:0006498)2.06346164
56Pancreatic cysts (HP:0001737)2.04228602
57Obsessive-compulsive behavior (HP:0000722)2.03904583
58Impulsivity (HP:0100710)2.03746552
59Prominent nose (HP:0000448)2.02309919
60Abnormality of chromosome stability (HP:0003220)1.99545001
61Reticulocytopenia (HP:0001896)1.99345392
62Glioma (HP:0009733)1.99096200
63Abnormality of the incisor (HP:0000676)1.96896604
64Intestinal atresia (HP:0011100)1.95087533
65Clubbing of toes (HP:0100760)1.93932324
66Horseshoe kidney (HP:0000085)1.93718997
67Pancreatic fibrosis (HP:0100732)1.93619762
68Abnormality of cochlea (HP:0000375)1.93379450
69Methylmalonic acidemia (HP:0002912)1.92525390
70Duplicated collecting system (HP:0000081)1.92383796
71Broad thumb (HP:0011304)1.91858336
72Abnormality of DNA repair (HP:0003254)1.90948543
73Cerebral edema (HP:0002181)1.90911058
74Lip pit (HP:0100267)1.89971862
75Abnormality of the ileum (HP:0001549)1.89116633
76Colon cancer (HP:0003003)1.88827678
77Neoplasm of striated muscle (HP:0009728)1.88818426
78Skin tags (HP:0010609)1.88523582
79Meckel diverticulum (HP:0002245)1.88115312
80Renal Fanconi syndrome (HP:0001994)1.86933375
81Aplasia/Hypoplasia of the uvula (HP:0010293)1.86683212
82Molar tooth sign on MRI (HP:0002419)1.84627326
83Abnormality of midbrain morphology (HP:0002418)1.84627326
84Gastrointestinal atresia (HP:0002589)1.84439549
85Oligodactyly (HP:0012165)1.84210811
86Facial hemangioma (HP:0000329)1.82945666
87Macroorchidism (HP:0000053)1.82314561
88Abnormality of methionine metabolism (HP:0010901)1.81733622
89Abnormal hair whorl (HP:0010721)1.81677823
90Short middle phalanx of the 5th finger (HP:0004220)1.80023020
91Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79826065
92Skull defect (HP:0001362)1.78996624
93Nephronophthisis (HP:0000090)1.78509928
94Abnormality of the renal collecting system (HP:0004742)1.77922486
95Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76999442
96Aplastic anemia (HP:0001915)1.76552260
97Renal duplication (HP:0000075)1.76332181
98Intestinal malrotation (HP:0002566)1.75564863
99Deep philtrum (HP:0002002)1.75525249
100Abnormality of the septum pellucidum (HP:0007375)1.75168777
101Hypoplasia of the pons (HP:0012110)1.74766024
102Hyperacusis (HP:0010780)1.74693360
103Anophthalmia (HP:0000528)1.74679377
104Abnormality of the pons (HP:0007361)1.74348006
105Short thumb (HP:0009778)1.73710939
106Sparse lateral eyebrow (HP:0005338)1.73144756
107Leukodystrophy (HP:0002415)1.72477161
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.72185215
109Oligodactyly (hands) (HP:0001180)1.72021760
110Absent septum pellucidum (HP:0001331)1.71990904
111Myelodysplasia (HP:0002863)1.71934731
112Acute myeloid leukemia (HP:0004808)1.71918147
113Abnormality of the preputium (HP:0100587)1.71796203
114Abnormality of the columella (HP:0009929)1.71420476
115Nephroblastoma (Wilms tumor) (HP:0002667)1.71126477
116Small intestinal stenosis (HP:0012848)1.71024794
117Duodenal stenosis (HP:0100867)1.71024794
118Atresia of the external auditory canal (HP:0000413)1.70814214
119Median cleft lip (HP:0000161)1.69927807
120Respiratory difficulties (HP:0002880)1.69810023
121Preauricular skin tag (HP:0000384)1.69562178
122Short 5th finger (HP:0009237)1.68522770
123Basal cell carcinoma (HP:0002671)1.68366126
124Intestinal fistula (HP:0100819)1.67794657
125Hepatocellular necrosis (HP:0001404)1.67201784
126Abnormality of the nasal septum (HP:0000419)1.66891587
127Holoprosencephaly (HP:0001360)1.65947018
128Microtia (HP:0008551)1.65364870
129Stenosis of the external auditory canal (HP:0000402)1.64386077
130Preaxial hand polydactyly (HP:0001177)1.64157203
131Midline defect of the nose (HP:0004122)1.63399791
132Abnormality of the 4th metacarpal (HP:0010012)1.63220249
133Limited elbow extension (HP:0001377)1.62734089
134Supernumerary spleens (HP:0009799)1.62375616
135Small hand (HP:0200055)1.62029487
136Megaloblastic anemia (HP:0001889)1.61720603
137Cleft eyelid (HP:0000625)1.61486977
138Morphological abnormality of the inner ear (HP:0011390)1.60546804
139Abnormality of the carotid arteries (HP:0005344)1.59154011
140Congenital, generalized hypertrichosis (HP:0004540)1.59082098
141Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.58994120
142Low anterior hairline (HP:0000294)1.58517546
143True hermaphroditism (HP:0010459)1.58473785
144Broad palm (HP:0001169)1.58442514
145Pancreatic islet-cell hyperplasia (HP:0004510)1.57710210
146Abnormality of the duodenum (HP:0002246)1.57091722
147Sclerocornea (HP:0000647)1.56992520
148Choanal atresia (HP:0000453)1.56705379
149Broad alveolar ridges (HP:0000187)1.55020703
150Rhabdomyosarcoma (HP:0002859)1.54321981
151Aplasia cutis congenita (HP:0001057)1.54091163
152Embryonal renal neoplasm (HP:0011794)1.53650938
153Abnormally folded helix (HP:0008544)1.53223171
154Hypoplastic labia majora (HP:0000059)1.53107470
155Tented upper lip vermilion (HP:0010804)1.52804690
156Anteriorly placed anus (HP:0001545)1.52638565
157Broad phalanges of the hand (HP:0009768)1.50004401
158Duplication of thumb phalanx (HP:0009942)1.49949602
159Overriding aorta (HP:0002623)1.48720380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.78449700
2CDC74.52637980
3BRD44.39865142
4VRK23.32391232
5TNIK3.02881822
6MKNK12.98318088
7PNCK2.89871200
8MKNK22.75343493
9MST42.30281425
10NUAK12.15449330
11SIK32.05905589
12CAMK1G2.01946225
13BRSK22.01334141
14TAF12.00793631
15TSSK61.97450634
16NME11.93366426
17EEF2K1.92917616
18SRPK11.89939975
19NEK11.88743358
20CDK71.85317162
21ATR1.83987946
22VRK11.83891334
23TTK1.82690514
24ICK1.82558176
25SIK21.73322660
26NEK21.73073588
27CHEK11.67678223
28MAP3K101.64502383
29ZAK1.58016404
30PBK1.49006185
31WEE11.48551952
32BMPR1B1.47927702
33CAMK1D1.43455988
34FGFR21.43150478
35ALK1.42761948
36UHMK11.38524424
37STK161.37965788
38ATM1.33082253
39CDK41.32940166
40PASK1.31315602
41BCR1.22794270
42CHEK21.20974397
43EIF2AK31.20956425
44* MTOR1.20870862
45RPS6KB21.20268321
46* CDK21.19674679
47PLK11.18369060
48CDK61.16661479
49WNK31.14914018
50BUB11.12913996
51PLK31.12706213
52AURKB1.12668080
53* CDK11.04913253
54STK101.04678985
55TRIM281.04458963
56PLK21.01992673
57MAP4K11.01175983
58STK40.99959857
59CDC42BPA0.98903192
60CLK10.96723197
61EIF2AK20.96714916
62AKT30.95940665
63MELK0.91925426
64* CSNK1E0.89428578
65PLK40.86511040
66NLK0.83988842
67CDK190.83843873
68* MAPK140.83729813
69DMPK0.83662911
70TYRO30.82557392
71FGFR10.80558754
72CSNK1A1L0.80064552
73PRKDC0.79234586
74FRK0.77789226
75KSR10.76599065
76DYRK20.76182353
77NTRK20.76166379
78CSNK1D0.75850411
79* GSK3B0.74668342
80CHUK0.74291330
81WNK10.73397021
82NEK60.67655522
83WNK40.65756304
84EIF2AK10.64936433
85MAPK100.63301581
86MAP3K80.61802848
87INSRR0.61780818
88CCNB10.60410851
89AKT10.59075602
90STK38L0.58512309
91* MAPK10.56662201
92CSNK2A20.56014784
93STK30.54839818
94CDK90.53997728
95ERBB20.53071047
96EPHA20.52888893
97AKT20.52766437
98PDGFRB0.52702453
99PDGFRA0.52120164
100CASK0.50520609
101BTK0.49762436
102CDK30.47712120
103MAPK80.47246650
104RPS6KA40.46388891
105BMX0.43982942
106PAK40.43331750
107ACVR1B0.42800107
108LATS10.42676585
109MAP4K20.41603639
110PRKCI0.41425616
111TXK0.39955591
112DYRK30.39377449
113PIM10.39126723
114MARK20.38957471
115GRK10.37859310
116MAPKAPK50.37391432
117DYRK1A0.37389723
118MAPK90.36984865
119PAK20.36884459
120HIPK20.36573510
121ITK0.35548373
122STK240.35177715
123AURKA0.34716676
124PRKD20.34343688
125TEC0.33743980
126BRSK10.33219534
127PRKCG0.32509902
128YES10.32228351
129CDK80.31523719
130CAMK40.31509732
131MAPK150.31270360
132CSNK2A10.31044411
133OXSR10.30941926
134TGFBR10.28390857
135MAPKAPK20.28257886
136LCK0.27435432
137MAPK30.27128129
138MAP3K90.25535783
139CSNK1G10.25326530
140PDK20.24753765
141BRAF0.22991488
142FLT30.21213209

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.17256919
2Mismatch repair_Homo sapiens_hsa034303.00330265
3DNA replication_Homo sapiens_hsa030302.94693288
4Proteasome_Homo sapiens_hsa030502.83704539
5Protein export_Homo sapiens_hsa030602.71210671
6Oxidative phosphorylation_Homo sapiens_hsa001902.58491912
7Cell cycle_Homo sapiens_hsa041102.41979963
8* RNA transport_Homo sapiens_hsa030132.32349064
9Parkinsons disease_Homo sapiens_hsa050122.31395031
10* mRNA surveillance pathway_Homo sapiens_hsa030152.24825512
11Homologous recombination_Homo sapiens_hsa034402.15135370
12Non-homologous end-joining_Homo sapiens_hsa034502.06558651
13Base excision repair_Homo sapiens_hsa034102.04440682
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02485511
15Fanconi anemia pathway_Homo sapiens_hsa034602.00327113
16Huntingtons disease_Homo sapiens_hsa050161.96241268
17Nucleotide excision repair_Homo sapiens_hsa034201.78400679
18RNA polymerase_Homo sapiens_hsa030201.72799315
19RNA degradation_Homo sapiens_hsa030181.70318361
20Notch signaling pathway_Homo sapiens_hsa043301.62206992
21Basal cell carcinoma_Homo sapiens_hsa052171.59870234
22Ribosome_Homo sapiens_hsa030101.47294305
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42031562
24Alzheimers disease_Homo sapiens_hsa050101.37069168
25MicroRNAs in cancer_Homo sapiens_hsa052061.35531033
26Basal transcription factors_Homo sapiens_hsa030221.29767155
27Lysine degradation_Homo sapiens_hsa003101.28373290
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23584766
29Cardiac muscle contraction_Homo sapiens_hsa042601.22069335
30Hedgehog signaling pathway_Homo sapiens_hsa043401.20875137
31Propanoate metabolism_Homo sapiens_hsa006401.18879047
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18751391
33Wnt signaling pathway_Homo sapiens_hsa043101.14081765
34Hippo signaling pathway_Homo sapiens_hsa043901.13168041
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11118044
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09637971
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07929300
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07857386
39Oocyte meiosis_Homo sapiens_hsa041141.07724545
40HTLV-I infection_Homo sapiens_hsa051661.07582536
41Selenocompound metabolism_Homo sapiens_hsa004501.06385928
42Epstein-Barr virus infection_Homo sapiens_hsa051691.05503528
43One carbon pool by folate_Homo sapiens_hsa006701.03952141
44Chronic myeloid leukemia_Homo sapiens_hsa052201.01030757
45Adherens junction_Homo sapiens_hsa045201.00490761
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.00092854
47Colorectal cancer_Homo sapiens_hsa052100.98391796
48Herpes simplex infection_Homo sapiens_hsa051680.97244937
49p53 signaling pathway_Homo sapiens_hsa041150.97221951
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96306634
51Primary immunodeficiency_Homo sapiens_hsa053400.94168975
52TGF-beta signaling pathway_Homo sapiens_hsa043500.93878835
53Pyruvate metabolism_Homo sapiens_hsa006200.89988621
54Small cell lung cancer_Homo sapiens_hsa052220.89126260
55Pathways in cancer_Homo sapiens_hsa052000.87621394
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87306715
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86071150
58Prostate cancer_Homo sapiens_hsa052150.83443744
59Pyrimidine metabolism_Homo sapiens_hsa002400.83059214
60T cell receptor signaling pathway_Homo sapiens_hsa046600.81661969
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81445437
62Renal cell carcinoma_Homo sapiens_hsa052110.78654215
63Viral carcinogenesis_Homo sapiens_hsa052030.72473460
64Axon guidance_Homo sapiens_hsa043600.72185709
65Proteoglycans in cancer_Homo sapiens_hsa052050.71142699
66B cell receptor signaling pathway_Homo sapiens_hsa046620.68901530
67Hepatitis B_Homo sapiens_hsa051610.68206156
68Steroid biosynthesis_Homo sapiens_hsa001000.68181863
69Non-small cell lung cancer_Homo sapiens_hsa052230.67430187
70Viral myocarditis_Homo sapiens_hsa054160.66910125
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66542690
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66404462
73Phototransduction_Homo sapiens_hsa047440.64247461
74ErbB signaling pathway_Homo sapiens_hsa040120.63709672
75Tight junction_Homo sapiens_hsa045300.62911306
76Pancreatic cancer_Homo sapiens_hsa052120.62599636
77mTOR signaling pathway_Homo sapiens_hsa041500.62084549
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61845603
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61128248
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.60782017
81Folate biosynthesis_Homo sapiens_hsa007900.60131597
82Acute myeloid leukemia_Homo sapiens_hsa052210.59963486
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59592744
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59171059
85Shigellosis_Homo sapiens_hsa051310.59043261
86MAPK signaling pathway_Homo sapiens_hsa040100.58376559
87Melanogenesis_Homo sapiens_hsa049160.57895097
88Butanoate metabolism_Homo sapiens_hsa006500.57075184
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.56072145
90Antigen processing and presentation_Homo sapiens_hsa046120.56047274
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55507836
92Endometrial cancer_Homo sapiens_hsa052130.55464351
93Dorso-ventral axis formation_Homo sapiens_hsa043200.55157194
94Olfactory transduction_Homo sapiens_hsa047400.54456858
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.53686681
96Vitamin B6 metabolism_Homo sapiens_hsa007500.53442857
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52957934
98Glioma_Homo sapiens_hsa052140.52629307
99Hematopoietic cell lineage_Homo sapiens_hsa046400.52096828
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52057757
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51095379
102Choline metabolism in cancer_Homo sapiens_hsa052310.50532399
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48605771
104Purine metabolism_Homo sapiens_hsa002300.47851376
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46974787
106Measles_Homo sapiens_hsa051620.46790584
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46682130
108Rap1 signaling pathway_Homo sapiens_hsa040150.46477374
109Focal adhesion_Homo sapiens_hsa045100.46018397
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45797546
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45744759
112Metabolic pathways_Homo sapiens_hsa011000.45524509
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44742334
114Circadian rhythm_Homo sapiens_hsa047100.44698435
115FoxO signaling pathway_Homo sapiens_hsa040680.44003299
116Melanoma_Homo sapiens_hsa052180.43423966
117Estrogen signaling pathway_Homo sapiens_hsa049150.43416648
118Thyroid cancer_Homo sapiens_hsa052160.43396566
119Nicotine addiction_Homo sapiens_hsa050330.43044375
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42750081
121Long-term potentiation_Homo sapiens_hsa047200.42580332
122ECM-receptor interaction_Homo sapiens_hsa045120.41824125
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41571286
124VEGF signaling pathway_Homo sapiens_hsa043700.41394739
125Chemokine signaling pathway_Homo sapiens_hsa040620.39862440
126Long-term depression_Homo sapiens_hsa047300.39115890
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.38976069
128Biosynthesis of amino acids_Homo sapiens_hsa012300.38790672
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37468012
130HIF-1 signaling pathway_Homo sapiens_hsa040660.37334112
131Bladder cancer_Homo sapiens_hsa052190.36328854
132Vitamin digestion and absorption_Homo sapiens_hsa049770.35509992
133Glutathione metabolism_Homo sapiens_hsa004800.34988222
134Carbon metabolism_Homo sapiens_hsa012000.31168214
135Taste transduction_Homo sapiens_hsa047420.28115427
136Nitrogen metabolism_Homo sapiens_hsa009100.27831322
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23666604
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.21822770
139Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20742326
140Fatty acid elongation_Homo sapiens_hsa000620.20092093
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19263099
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19054250
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12252075
144Retinol metabolism_Homo sapiens_hsa008300.12129496
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11224910
146Linoleic acid metabolism_Homo sapiens_hsa005910.10891659
147Fatty acid metabolism_Homo sapiens_hsa012120.06816628
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06484019
149Regulation of autophagy_Homo sapiens_hsa041400.05969997
150Ether lipid metabolism_Homo sapiens_hsa005650.03344898
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.03081867
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.01217740
153Peroxisome_Homo sapiens_hsa041460.00044509
1542-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210-0.0002688

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