SRRM1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somite development (GO:0061053)6.11885596
2limb bud formation (GO:0060174)4.55306634
3DNA deamination (GO:0045006)4.50748684
4negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.40806054
5artery development (GO:0060840)4.34969984
6negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.33006061
7CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.29366857
8regulation of mesoderm development (GO:2000380)4.24298883
9positive thymic T cell selection (GO:0045059)4.20267106
10negative regulation of smooth muscle cell differentiation (GO:0051151)4.13584083
11DNA integration (GO:0015074)4.09953622
12thalamus development (GO:0021794)4.07814183
13water-soluble vitamin biosynthetic process (GO:0042364)4.04866957
14cell proliferation involved in metanephros development (GO:0072203)4.01118430
15embryonic foregut morphogenesis (GO:0048617)4.00093679
16positive T cell selection (GO:0043368)3.98079472
17lung lobe morphogenesis (GO:0060463)3.96544132
18piRNA metabolic process (GO:0034587)3.96501360
19negative thymic T cell selection (GO:0045060)3.94245957
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.89896647
21negative T cell selection (GO:0043383)3.89253521
22positive regulation of oligodendrocyte differentiation (GO:0048714)3.85236085
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.81067269
24lung epithelium development (GO:0060428)3.77311389
25positive regulation of T cell differentiation in thymus (GO:0033089)3.71802665
26prostate gland growth (GO:0060736)3.68913741
27resolution of meiotic recombination intermediates (GO:0000712)3.60129544
28lymphoid progenitor cell differentiation (GO:0002320)3.59110059
29L-fucose catabolic process (GO:0042355)3.54183138
30fucose catabolic process (GO:0019317)3.54183138
31L-fucose metabolic process (GO:0042354)3.54183138
32negative regulation of kidney development (GO:0090185)3.53532582
33regulation of mesenchymal cell apoptotic process (GO:2001053)3.51668463
34negative regulation of DNA-templated transcription, elongation (GO:0032785)3.43589816
35lung-associated mesenchyme development (GO:0060484)3.43288899
36rRNA catabolic process (GO:0016075)3.35373684
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32126827
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26483378
39negative regulation of alpha-beta T cell differentiation (GO:0046639)3.26452162
40hindbrain development (GO:0030902)3.25396999
41cilium or flagellum-dependent cell motility (GO:0001539)3.24987903
42dorsal/ventral neural tube patterning (GO:0021904)3.23008332
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.21973989
44respiratory chain complex IV assembly (GO:0008535)3.21026382
45protein complex biogenesis (GO:0070271)3.20713596
46axoneme assembly (GO:0035082)3.20377505
47proteasome assembly (GO:0043248)3.19561917
48meiotic chromosome segregation (GO:0045132)3.15958624
49T cell lineage commitment (GO:0002360)3.10696544
50regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.10604978
51myotube differentiation (GO:0014902)3.09075738
52rRNA modification (GO:0000154)3.08846998
53protein polyglutamylation (GO:0018095)3.08656529
54intra-S DNA damage checkpoint (GO:0031573)3.04700930
55mesenchymal cell proliferation (GO:0010463)3.04503618
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02083356
57ATP synthesis coupled proton transport (GO:0015986)3.02083356
58reciprocal meiotic recombination (GO:0007131)3.00861101
59reciprocal DNA recombination (GO:0035825)3.00861101
60epithelial cilium movement (GO:0003351)2.99487250
61regulation of DNA endoreduplication (GO:0032875)2.97008192
62negative regulation of axon guidance (GO:1902668)2.94121497
63cell proliferation involved in kidney development (GO:0072111)2.93683124
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92849740
65regulation of mitotic spindle checkpoint (GO:1903504)2.92849740
66mitochondrial respiratory chain complex assembly (GO:0033108)2.87098122
67pseudouridine synthesis (GO:0001522)2.86866744
68branch elongation of an epithelium (GO:0060602)2.85610508
69protein neddylation (GO:0045116)2.82865953
70signal peptide processing (GO:0006465)2.80827694
71embryonic digestive tract morphogenesis (GO:0048557)2.79615711
72regulation of chemokine-mediated signaling pathway (GO:0070099)2.78865653
73cytochrome complex assembly (GO:0017004)2.77647191
74platelet dense granule organization (GO:0060155)2.75015284
75RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74514507
76cilium movement (GO:0003341)2.72726558
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70588714
78regulation of cilium movement (GO:0003352)2.69038573
79recombinational repair (GO:0000725)2.68614815
80double-strand break repair via homologous recombination (GO:0000724)2.67518059
81ectoderm development (GO:0007398)2.65789534
82male meiosis I (GO:0007141)2.65555004
83DNA double-strand break processing (GO:0000729)2.64123023
84histone mRNA metabolic process (GO:0008334)2.63705829
85DNA strand renaturation (GO:0000733)2.61858377
86mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60870246
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.60870246
88NADH dehydrogenase complex assembly (GO:0010257)2.60870246
89cellular response to lithium ion (GO:0071285)2.59443015
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59218254
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59218254
92negative regulation of leukocyte chemotaxis (GO:0002689)2.57853216
93protein peptidyl-prolyl isomerization (GO:0000413)2.57741434
94renal system development (GO:0072001)2.57179127
95organ formation (GO:0048645)2.56622326
96centriole assembly (GO:0098534)2.55500436
97synapsis (GO:0007129)2.54582930
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.53557926
99centriole replication (GO:0007099)2.52800412
100astrocyte differentiation (GO:0048708)2.52775879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.32344157
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.40061871
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.84515272
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.16747579
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82272147
6VDR_23849224_ChIP-Seq_CD4+_Human2.62637307
7ZNF274_21170338_ChIP-Seq_K562_Hela2.55254652
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51046669
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50360694
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48020018
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44365019
12VDR_22108803_ChIP-Seq_LS180_Human2.40454810
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.38372456
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.36647219
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36058773
16EWS_26573619_Chip-Seq_HEK293_Human2.32460669
17ELK1_19687146_ChIP-ChIP_HELA_Human2.18868391
18FOXP3_21729870_ChIP-Seq_TREG_Human1.94871147
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90667283
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.87672827
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85422244
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82125459
23IGF1R_20145208_ChIP-Seq_DFB_Human1.79517106
24MYC_18940864_ChIP-ChIP_HL60_Human1.78912455
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73579391
26FUS_26573619_Chip-Seq_HEK293_Human1.69088941
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68507177
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68164939
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63378346
30P300_19829295_ChIP-Seq_ESCs_Human1.59943263
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58462427
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55179795
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54546469
34TP53_22573176_ChIP-Seq_HFKS_Human1.53383265
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51571381
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50414646
37TAF15_26573619_Chip-Seq_HEK293_Human1.48815796
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48231856
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45645099
40BCAT_22108803_ChIP-Seq_LS180_Human1.43234073
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.40717624
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40089297
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.39974700
44NANOG_19829295_ChIP-Seq_ESCs_Human1.39026483
45SOX2_19829295_ChIP-Seq_ESCs_Human1.39026483
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36601891
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35445642
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35358093
49ER_23166858_ChIP-Seq_MCF-7_Human1.33585101
50CBP_20019798_ChIP-Seq_JUKART_Human1.33452853
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33452853
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31599627
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25349254
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.25349254
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23013817
56AR_20517297_ChIP-Seq_VCAP_Human1.22921558
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22682002
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22505480
59HTT_18923047_ChIP-ChIP_STHdh_Human1.12245530
60EZH2_22144423_ChIP-Seq_EOC_Human1.12149585
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11978023
62TCF4_22108803_ChIP-Seq_LS180_Human1.11128263
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.09951181
64GABP_19822575_ChIP-Seq_HepG2_Human1.09167766
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.07078870
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05535176
67GBX2_23144817_ChIP-Seq_PC3_Human1.04295714
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03408767
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02604459
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02439592
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.02319967
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01944259
73SMAD4_21799915_ChIP-Seq_A2780_Human1.01924367
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01099451
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01099451
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00626784
77STAT3_23295773_ChIP-Seq_U87_Human1.00033284
78RUNX2_22187159_ChIP-Seq_PCA_Human0.99778707
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99453625
80TCF4_23295773_ChIP-Seq_U87_Human0.98957633
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98228966
82KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98023591
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97773905
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97385172
85AR_25329375_ChIP-Seq_VCAP_Human0.96758670
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96019895
87IRF8_22096565_ChIP-ChIP_GC-B_Human0.93825204
88NCOR_22424771_ChIP-Seq_293T_Human0.93303736
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92626940
90GATA3_26560356_Chip-Seq_TH1_Human0.92473826
91RBPJ_21746931_ChIP-Seq_IB4_Human0.92257823
92PHF8_20622853_ChIP-Seq_HELA_Human0.91090207
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.90803948
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90374649
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90086517
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89309469
97GATA6_21074721_ChIP-Seq_CACO-2_Human0.89146847
98HOXB7_26014856_ChIP-Seq_BT474_Human0.89136731
99TTF2_22483619_ChIP-Seq_HELA_Human0.89109653
100FOXH1_21741376_ChIP-Seq_EPCs_Human0.88252366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ7.49445364
2MP0002102_abnormal_ear_morphology5.51021492
3MP0002234_abnormal_pharynx_morphology4.59780399
4MP0006292_abnormal_olfactory_placode3.55099830
5MP0000383_abnormal_hair_follicle3.26601330
6MP0009053_abnormal_anal_canal2.97469352
7MP0003195_calcinosis2.72763845
8MP0003787_abnormal_imprinting2.35147760
9MP0008995_early_reproductive_senescence2.11376900
10MP0010678_abnormal_skin_adnexa2.09849883
11MP0000372_irregular_coat_pigmentation1.97943997
12MP0001293_anophthalmia1.97631806
13MP0008877_abnormal_DNA_methylation1.97564954
14MP0003938_abnormal_ear_development1.95489809
15MP0008789_abnormal_olfactory_epithelium1.92004219
16MP0008058_abnormal_DNA_repair1.91514655
17MP0004147_increased_porphyrin_level1.81907297
18MP0003119_abnormal_digestive_system1.77250567
19MP0008057_abnormal_DNA_replication1.73562412
20MP0006072_abnormal_retinal_apoptosis1.70383237
21MP0000462_abnormal_digestive_system1.67274038
22MP0003786_premature_aging1.59507766
23MP0002138_abnormal_hepatobiliary_system1.57323761
24MP0003890_abnormal_embryonic-extraembry1.54238800
25MP0002282_abnormal_trachea_morphology1.50882929
26MP0002233_abnormal_nose_morphology1.50206967
27MP0001661_extended_life_span1.44956668
28MP0001873_stomach_inflammation1.44127088
29MP0005253_abnormal_eye_physiology1.41081814
30MP0000631_abnormal_neuroendocrine_gland1.34494058
31MP0003937_abnormal_limbs/digits/tail_de1.29051474
32MP0008872_abnormal_physiological_respon1.25937394
33MP0001485_abnormal_pinna_reflex1.25828447
34MP0005394_taste/olfaction_phenotype1.25080291
35MP0005499_abnormal_olfactory_system1.25080291
36MP0002277_abnormal_respiratory_mucosa1.23039321
37MP0003718_maternal_effect1.21003530
38MP0005551_abnormal_eye_electrophysiolog1.20477141
39MP0001984_abnormal_olfaction1.17588439
40MP0002160_abnormal_reproductive_system1.16777196
41MP0002163_abnormal_gland_morphology1.14448892
42MP0005671_abnormal_response_to1.10344428
43MP0002751_abnormal_autonomic_nervous1.09985698
44MP0008875_abnormal_xenobiotic_pharmacok1.07639541
45MP0005220_abnormal_exocrine_pancreas1.06985535
46MP0004133_heterotaxia1.06478383
47MP0000613_abnormal_salivary_gland1.02167110
48MP0002938_white_spotting1.01846810
49MP0001119_abnormal_female_reproductive0.98782897
50MP0000049_abnormal_middle_ear0.96867196
51MP0002210_abnormal_sex_determination0.95627518
52MP0006276_abnormal_autonomic_nervous0.95260556
53MP0000427_abnormal_hair_cycle0.94784802
54MP0003123_paternal_imprinting0.94018548
55MP0006035_abnormal_mitochondrial_morpho0.93979460
56MP0000569_abnormal_digit_pigmentation0.92827946
57MP0002653_abnormal_ependyma_morphology0.92597229
58MP0005389_reproductive_system_phenotype0.91111076
59MP0005646_abnormal_pituitary_gland0.89660367
60MP0005084_abnormal_gallbladder_morpholo0.89264832
61MP0004742_abnormal_vestibular_system0.87404357
62MP0010094_abnormal_chromosome_stability0.87287459
63MP0001835_abnormal_antigen_presentation0.85887135
64MP0003121_genomic_imprinting0.84667270
65MP0001929_abnormal_gametogenesis0.83523231
66MP0005391_vision/eye_phenotype0.83246792
67MP0001145_abnormal_male_reproductive0.81352174
68MP0000026_abnormal_inner_ear0.79276322
69MP0000653_abnormal_sex_gland0.78009606
70MP0001286_abnormal_eye_development0.74828630
71MP0002638_abnormal_pupillary_reflex0.74232784
72MP0001529_abnormal_vocalization0.73760231
73MP0003115_abnormal_respiratory_system0.73232131
74MP0003763_abnormal_thymus_physiology0.72829728
75MP0001764_abnormal_homeostasis0.72438589
76MP0000428_abnormal_craniofacial_morphol0.72267614
77MP0004145_abnormal_muscle_electrophysio0.71601273
78MP0009697_abnormal_copulation0.71269560
79MP0003698_abnormal_male_reproductive0.71070987
80MP0002736_abnormal_nociception_after0.69115443
81MP0003136_yellow_coat_color0.68639621
82MP0005381_digestive/alimentary_phenotyp0.68243542
83MP0003567_abnormal_fetal_cardiomyocyte0.67219504
84MP0002098_abnormal_vibrissa_morphology0.65505590
85MP0005636_abnormal_mineral_homeostasis0.65165300
86MP0006036_abnormal_mitochondrial_physio0.65089486
87MP0002928_abnormal_bile_duct0.62181291
88MP0004043_abnormal_pH_regulation0.59563453
89MP0005379_endocrine/exocrine_gland_phen0.57926443
90MP0002272_abnormal_nervous_system0.55654377
91MP0010030_abnormal_orbit_morphology0.55533520
92MP0005167_abnormal_blood-brain_barrier0.53806946
93MP0001944_abnormal_pancreas_morphology0.53378052
94MP0000467_abnormal_esophagus_morphology0.53114784
95MP0002084_abnormal_developmental_patter0.53058536
96MP0003693_abnormal_embryo_hatching0.53036420
97MP0002132_abnormal_respiratory_system0.52813386
98MP0001963_abnormal_hearing_physiology0.51447246
99MP0003936_abnormal_reproductive_system0.51052727
100MP0005377_hearing/vestibular/ear_phenot0.51003764

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.96596726
2Bilateral microphthalmos (HP:0007633)3.81410532
3Molar tooth sign on MRI (HP:0002419)3.49339001
4Abnormality of midbrain morphology (HP:0002418)3.49339001
5Increased hepatocellular lipid droplets (HP:0006565)3.36066230
6Pancreatic fibrosis (HP:0100732)3.26092911
7Absent/shortened dynein arms (HP:0200106)3.22491407
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.22491407
9Abnormality of the renal cortex (HP:0011035)3.22333221
10Maternal diabetes (HP:0009800)3.15869698
11Acute necrotizing encephalopathy (HP:0006965)3.12127646
12Nephronophthisis (HP:0000090)3.11528803
13Lipid accumulation in hepatocytes (HP:0006561)3.06038841
14Abnormality of the renal medulla (HP:0100957)2.98587968
15True hermaphroditism (HP:0010459)2.98113317
16Acute encephalopathy (HP:0006846)2.88788411
17Type II lissencephaly (HP:0007260)2.84771628
18Mitochondrial inheritance (HP:0001427)2.83827936
19Hypoplasia of the pons (HP:0012110)2.82931114
20Abnormal number of incisors (HP:0011064)2.82079244
21Severe combined immunodeficiency (HP:0004430)2.78305368
22Increased CSF lactate (HP:0002490)2.73730458
23Attenuation of retinal blood vessels (HP:0007843)2.70659914
24Bile duct proliferation (HP:0001408)2.68664887
25Abnormal biliary tract physiology (HP:0012439)2.68664887
26Tubular atrophy (HP:0000092)2.66808007
27Abnormality of the pons (HP:0007361)2.66621913
28Dyschromatopsia (HP:0007641)2.64477273
29Abnormal mitochondria in muscle tissue (HP:0008316)2.64283926
30Triphalangeal thumb (HP:0001199)2.63038238
31Renal cortical cysts (HP:0000803)2.61485492
32Progressive macrocephaly (HP:0004481)2.60166063
33Congenital, generalized hypertrichosis (HP:0004540)2.48001572
34Cystic liver disease (HP:0006706)2.45940749
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44159433
36Postaxial foot polydactyly (HP:0001830)2.41957191
37Anophthalmia (HP:0000528)2.35003069
38Optic disc pallor (HP:0000543)2.33797487
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32414204
40Thyroiditis (HP:0100646)2.31127798
41Congenital stationary night blindness (HP:0007642)2.28796004
42Renal Fanconi syndrome (HP:0001994)2.28500808
43Oligodactyly (hands) (HP:0001180)2.28088799
44Abnormal respiratory epithelium morphology (HP:0012253)2.27659115
45Abnormal respiratory motile cilium morphology (HP:0005938)2.27659115
46Abnormality of the ileum (HP:0001549)2.27571427
47Abnormal drinking behavior (HP:0030082)2.27498133
48Polydipsia (HP:0001959)2.27498133
49Cerebral edema (HP:0002181)2.27394944
50Meckel diverticulum (HP:0002245)2.24290471
51Tented upper lip vermilion (HP:0010804)2.22795901
52Duodenal stenosis (HP:0100867)2.20492959
53Small intestinal stenosis (HP:0012848)2.20492959
54Growth hormone deficiency (HP:0000824)2.17666644
55Porencephaly (HP:0002132)2.16953224
56Hypothermia (HP:0002045)2.16006286
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.15735914
58Abnormal ciliary motility (HP:0012262)2.13219454
59Submucous cleft hard palate (HP:0000176)2.12399499
60Chromsome breakage (HP:0040012)2.11749149
61Preaxial hand polydactyly (HP:0001177)2.11280575
62Combined immunodeficiency (HP:0005387)2.07326314
63Medial flaring of the eyebrow (HP:0010747)2.05647335
64Colon cancer (HP:0003003)2.04808630
65Increased intramyocellular lipid droplets (HP:0012240)2.04780121
66Hepatocellular necrosis (HP:0001404)2.03921007
67Abnormality of the duodenum (HP:0002246)2.02039399
68Abnormal rod and cone electroretinograms (HP:0008323)2.01686913
69Constricted visual fields (HP:0001133)2.00564952
70Cerebellar dysplasia (HP:0007033)2.00308561
71Tubulointerstitial abnormality (HP:0001969)1.96346996
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93312936
73Central scotoma (HP:0000603)1.93164326
74Tubulointerstitial fibrosis (HP:0005576)1.92990605
75Preaxial foot polydactyly (HP:0001841)1.91091700
76Glycosuria (HP:0003076)1.89993534
77Abnormality of urine glucose concentration (HP:0011016)1.89993534
78IgG deficiency (HP:0004315)1.87070362
79Congenital hepatic fibrosis (HP:0002612)1.86612104
80Exertional dyspnea (HP:0002875)1.86057634
81Hepatic necrosis (HP:0002605)1.85784404
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85780015
83Supernumerary spleens (HP:0009799)1.85592043
84Abnormality of chromosome stability (HP:0003220)1.85165400
85Gonadal dysgenesis (HP:0000133)1.84287905
86Increased serum lactate (HP:0002151)1.84111332
87Pendular nystagmus (HP:0012043)1.82020714
88Respiratory difficulties (HP:0002880)1.78433986
89Polyuria (HP:0000103)1.78131145
90Abnormality of the preputium (HP:0100587)1.76961492
91Gonadotropin excess (HP:0000837)1.74827260
92Concave nail (HP:0001598)1.74658031
93Abolished electroretinogram (ERG) (HP:0000550)1.74285736
94Hyperglycinuria (HP:0003108)1.73852251
95Bony spicule pigmentary retinopathy (HP:0007737)1.72755732
96Aplasia/hypoplasia of the uterus (HP:0008684)1.71975605
97Sloping forehead (HP:0000340)1.71827428
98Abnormality of eosinophils (HP:0001879)1.71797204
99Keratoconus (HP:0000563)1.71457104
100Increased corneal curvature (HP:0100692)1.71457104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.93409433
2TLK13.08558741
3FRK2.97237400
4VRK12.95770307
5ZAK2.93313674
6SRPK12.72633301
7TSSK62.59008098
8NUAK12.55834405
9BMPR1B2.37323977
10TXK2.37118405
11WNK41.94689548
12ADRBK21.85969740
13PASK1.77806288
14MST41.73719924
15STK391.72850771
16TAF11.71485178
17TNIK1.62229154
18MAP3K41.61016576
19CDK191.59729495
20ACVR1B1.57835008
21MAP4K21.57355294
22CDK81.48697680
23EIF2AK11.47506822
24PLK41.45909456
25CSNK1A1L1.39716083
26MUSK1.39615144
27AKT31.37960453
28CSNK1G21.36656781
29NEK11.33954751
30PLK21.30995374
31GRK11.27625832
32PLK31.23252477
33CSNK1G11.21440731
34OXSR11.19688439
35TRIM281.17230096
36CSNK1G31.13296492
37TAOK31.10663475
38MELK1.05702634
39BRSK21.04258370
40MKNK11.03276834
41PIK3CA0.96037478
42NME10.95722616
43RPS6KA40.95230237
44TGFBR10.91742077
45TNK20.90670621
46RPS6KA50.85893295
47TEC0.84388561
48LMTK20.82448764
49MAP2K70.79730840
50WNK30.74599767
51IRAK10.73745565
52MAPKAPK30.72579720
53TESK20.72558218
54IKBKE0.71736616
55DYRK20.67447975
56STK30.66487839
57EIF2AK30.66217592
58TIE10.65719633
59MKNK20.64214322
60IRAK20.61600696
61PRKCQ0.61230910
62PLK10.60181208
63INSRR0.59524572
64CDC70.59054068
65EIF2AK20.58494110
66CHUK0.58134513
67ATM0.52874238
68ATR0.52741436
69ADRBK10.52223251
70PRKCE0.52047662
71NEK90.50917330
72PDK20.49950340
73IKBKB0.49171779
74BTK0.46160805
75CCNB10.45227650
76GRK50.44378984
77EPHA40.44213058
78MAP4K10.43773482
79CSNK2A10.43353936
80MAPK130.43281886
81PNCK0.43182960
82CAMKK20.42426836
83PBK0.42255761
84CSNK2A20.41322710
85MAPKAPK50.40058037
86CDK90.39988733
87DAPK20.38331360
88BCR0.38262281
89CHEK20.37715369
90BRSK10.37468114
91AURKA0.34602481
92CSNK1D0.34518138
93CSNK1E0.33374301
94PIM10.32650835
95PRKG20.32325012
96WEE10.31741549
97GRK70.30727680
98ERBB30.30529011
99ITK0.30271581
100SGK10.29286267

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.30172689
2RNA polymerase_Homo sapiens_hsa030202.90596754
3Oxidative phosphorylation_Homo sapiens_hsa001902.86920959
4Homologous recombination_Homo sapiens_hsa034402.81570628
5Ribosome_Homo sapiens_hsa030102.68166190
6Non-homologous end-joining_Homo sapiens_hsa034502.54167740
7Protein export_Homo sapiens_hsa030602.53514739
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46331765
9Primary immunodeficiency_Homo sapiens_hsa053402.42851595
10Fanconi anemia pathway_Homo sapiens_hsa034602.39010599
11Basal transcription factors_Homo sapiens_hsa030222.38975604
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34993859
13One carbon pool by folate_Homo sapiens_hsa006702.25135676
14Parkinsons disease_Homo sapiens_hsa050122.18306693
15RNA degradation_Homo sapiens_hsa030182.17095719
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16144616
17Huntingtons disease_Homo sapiens_hsa050162.00201520
18Propanoate metabolism_Homo sapiens_hsa006401.95585965
19Phototransduction_Homo sapiens_hsa047441.92778398
20Butanoate metabolism_Homo sapiens_hsa006501.72734066
21RNA transport_Homo sapiens_hsa030131.67788164
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.62950112
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56459743
24Spliceosome_Homo sapiens_hsa030401.55039817
25Linoleic acid metabolism_Homo sapiens_hsa005911.48359296
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38999706
27Alzheimers disease_Homo sapiens_hsa050101.37964929
28Nitrogen metabolism_Homo sapiens_hsa009101.35456196
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34822647
30Mismatch repair_Homo sapiens_hsa034301.34208878
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32622681
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29778410
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29034807
34Nucleotide excision repair_Homo sapiens_hsa034201.24257458
35Caffeine metabolism_Homo sapiens_hsa002321.21582290
36Olfactory transduction_Homo sapiens_hsa047401.21034897
37Tryptophan metabolism_Homo sapiens_hsa003801.20361608
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17066153
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16746808
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15524152
41Phenylalanine metabolism_Homo sapiens_hsa003601.10744490
42Hedgehog signaling pathway_Homo sapiens_hsa043401.05300195
43Basal cell carcinoma_Homo sapiens_hsa052171.04353494
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.03199098
45Peroxisome_Homo sapiens_hsa041461.01027666
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99218636
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97280794
48Pyrimidine metabolism_Homo sapiens_hsa002400.94091900
49Histidine metabolism_Homo sapiens_hsa003400.89051571
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86561470
51Retinol metabolism_Homo sapiens_hsa008300.86462764
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83080437
53Purine metabolism_Homo sapiens_hsa002300.82084079
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.80651326
55Cardiac muscle contraction_Homo sapiens_hsa042600.78968951
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78744281
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75122793
58Regulation of autophagy_Homo sapiens_hsa041400.72950633
59Antigen processing and presentation_Homo sapiens_hsa046120.68739587
60Metabolic pathways_Homo sapiens_hsa011000.67839425
61Sulfur metabolism_Homo sapiens_hsa009200.67553104
62Hematopoietic cell lineage_Homo sapiens_hsa046400.64756573
63beta-Alanine metabolism_Homo sapiens_hsa004100.64718315
64DNA replication_Homo sapiens_hsa030300.64301661
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.62154713
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.61918878
67Chemical carcinogenesis_Homo sapiens_hsa052040.60048831
68Sulfur relay system_Homo sapiens_hsa041220.57480795
69Collecting duct acid secretion_Homo sapiens_hsa049660.57223349
70Ether lipid metabolism_Homo sapiens_hsa005650.56696355
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.55719821
72Tyrosine metabolism_Homo sapiens_hsa003500.55290259
73Systemic lupus erythematosus_Homo sapiens_hsa053220.54318823
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53600215
75Fatty acid metabolism_Homo sapiens_hsa012120.52325083
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52004962
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51955722
78Ovarian steroidogenesis_Homo sapiens_hsa049130.51490977
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50476833
80ABC transporters_Homo sapiens_hsa020100.49105601
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48039751
82Fatty acid elongation_Homo sapiens_hsa000620.44599048
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44454452
84Allograft rejection_Homo sapiens_hsa053300.44390598
85TGF-beta signaling pathway_Homo sapiens_hsa043500.43807934
86Nicotine addiction_Homo sapiens_hsa050330.43682705
87Fatty acid degradation_Homo sapiens_hsa000710.41095825
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40772545
89Fatty acid biosynthesis_Homo sapiens_hsa000610.38962837
90Graft-versus-host disease_Homo sapiens_hsa053320.38252726
91Folate biosynthesis_Homo sapiens_hsa007900.35536902
92Dorso-ventral axis formation_Homo sapiens_hsa043200.35157206
93Base excision repair_Homo sapiens_hsa034100.34098882
94Arachidonic acid metabolism_Homo sapiens_hsa005900.33702503
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.32977182
96mRNA surveillance pathway_Homo sapiens_hsa030150.32002063
97Asthma_Homo sapiens_hsa053100.31868025
98T cell receptor signaling pathway_Homo sapiens_hsa046600.31640614
99Taste transduction_Homo sapiens_hsa047420.30971655
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.30753902

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