SRRM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.07404828
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63751084
3vocalization behavior (GO:0071625)5.57846115
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.57762271
5locomotory exploration behavior (GO:0035641)5.50782090
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38159053
7synaptic vesicle maturation (GO:0016188)5.36817086
8synaptic vesicle exocytosis (GO:0016079)5.08823561
9regulation of glutamate receptor signaling pathway (GO:1900449)4.86653017
10protein localization to synapse (GO:0035418)4.86651169
11regulation of synaptic vesicle exocytosis (GO:2000300)4.79930563
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.70821522
13neuron cell-cell adhesion (GO:0007158)4.65670023
14neuronal action potential propagation (GO:0019227)4.57758301
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.53718718
16glutamate secretion (GO:0014047)4.52640628
17dendritic spine morphogenesis (GO:0060997)4.36970354
18exploration behavior (GO:0035640)4.34882028
19neurotransmitter secretion (GO:0007269)4.32312180
20glutamate receptor signaling pathway (GO:0007215)4.31412596
21regulation of synaptic vesicle transport (GO:1902803)4.30521509
22synaptic transmission, glutamatergic (GO:0035249)4.28938824
23regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.22050654
24regulation of neuronal synaptic plasticity (GO:0048168)4.21198175
25gamma-aminobutyric acid transport (GO:0015812)4.14564789
26layer formation in cerebral cortex (GO:0021819)4.11333592
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.06997705
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04915534
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.04737055
30neuron-neuron synaptic transmission (GO:0007270)4.03231530
31cerebellar Purkinje cell differentiation (GO:0021702)4.03182635
32neurotransmitter-gated ion channel clustering (GO:0072578)3.92126680
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.91166402
34long-term memory (GO:0007616)3.84565925
35positive regulation of membrane potential (GO:0045838)3.82454879
36regulation of synapse structural plasticity (GO:0051823)3.81474680
37neuron recognition (GO:0008038)3.79891583
38positive regulation of synapse maturation (GO:0090129)3.77780270
39transmission of nerve impulse (GO:0019226)3.77625749
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76903645
41response to pheromone (GO:0019236)3.70678520
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.67028394
43postsynaptic membrane organization (GO:0001941)3.64658121
44regulation of postsynaptic membrane potential (GO:0060078)3.64545149
45axonal fasciculation (GO:0007413)3.64364625
46neurotransmitter transport (GO:0006836)3.60100151
47axon ensheathment in central nervous system (GO:0032291)3.59491398
48central nervous system myelination (GO:0022010)3.59491398
49membrane hyperpolarization (GO:0060081)3.59010012
50cellular potassium ion homeostasis (GO:0030007)3.55341312
51pyrimidine nucleobase catabolic process (GO:0006208)3.53086094
52synaptic vesicle endocytosis (GO:0048488)3.52132072
53regulation of neurotransmitter secretion (GO:0046928)3.49384838
54establishment of mitochondrion localization (GO:0051654)3.48811208
55neuronal ion channel clustering (GO:0045161)3.47192115
56mechanosensory behavior (GO:0007638)3.46478562
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46455520
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45373442
59membrane depolarization during action potential (GO:0086010)3.43139154
60gamma-aminobutyric acid signaling pathway (GO:0007214)3.42275901
61regulation of vesicle fusion (GO:0031338)3.41513214
62auditory behavior (GO:0031223)3.37459525
63neuromuscular process controlling posture (GO:0050884)3.35906497
64potassium ion homeostasis (GO:0055075)3.32792764
65membrane depolarization (GO:0051899)3.32551317
66regulation of synaptic plasticity (GO:0048167)3.32317543
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.31073238
68regulation of dendritic spine morphogenesis (GO:0061001)3.30952902
69neuromuscular process controlling balance (GO:0050885)3.27947048
70cell migration in hindbrain (GO:0021535)3.27411078
71regulation of neurotransmitter levels (GO:0001505)3.27002544
72neuromuscular synaptic transmission (GO:0007274)3.26383734
73sodium ion export (GO:0071436)3.26161245
74regulation of neurotransmitter transport (GO:0051588)3.25290702
75dendrite morphogenesis (GO:0048813)3.24642927
76regulation of voltage-gated calcium channel activity (GO:1901385)3.23666320
77cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23272132
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22568165
79positive regulation of neurotransmitter transport (GO:0051590)3.21847511
80L-amino acid import (GO:0043092)3.21807333
81presynaptic membrane organization (GO:0097090)3.21753358
82response to auditory stimulus (GO:0010996)3.21545278
83innervation (GO:0060384)3.21222145
84glycine transport (GO:0015816)3.20851624
85cell communication by electrical coupling (GO:0010644)3.19532152
86presynaptic membrane assembly (GO:0097105)3.16160003
87prepulse inhibition (GO:0060134)3.14318137
88regulation of synapse maturation (GO:0090128)3.14066585
89dendritic spine organization (GO:0097061)3.12490147
90mitochondrion transport along microtubule (GO:0047497)3.11108610
91establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.11108610
92long-term synaptic potentiation (GO:0060291)3.10998754
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.10261618
94positive regulation of neurotransmitter secretion (GO:0001956)3.09843242
95synapse assembly (GO:0007416)3.08879870
96positive regulation of dendritic spine development (GO:0060999)3.08862690
97negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08618242
98proline transport (GO:0015824)3.08200449
99positive regulation of dendritic spine morphogenesis (GO:0061003)3.06394838
100activation of protein kinase A activity (GO:0034199)3.05400363
101adult walking behavior (GO:0007628)3.05105234
102learning (GO:0007612)3.05027742
103potassium ion import (GO:0010107)3.04389963
104cerebellar granule cell differentiation (GO:0021707)3.03850631
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01692946
106cell differentiation in hindbrain (GO:0021533)2.97011011
107cellular sodium ion homeostasis (GO:0006883)2.96449384
108nucleobase catabolic process (GO:0046113)2.94813294
109amino acid import (GO:0043090)2.93936487
110synaptic transmission (GO:0007268)2.93449737
111intraspecies interaction between organisms (GO:0051703)2.91792491
112social behavior (GO:0035176)2.91792491
113G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91482826
114regulation of dendritic spine development (GO:0060998)2.91453539
115neuromuscular process (GO:0050905)2.90481617
116chemosensory behavior (GO:0007635)2.90332325
117establishment of synaptic vesicle localization (GO:0097480)2.90258584
118regulation of synaptic transmission (GO:0050804)2.89933628
119mating behavior (GO:0007617)2.89035966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.15716917
2GBX2_23144817_ChIP-Seq_PC3_Human3.38865386
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19035970
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12307125
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01929306
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80270757
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78863333
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78863333
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.78316814
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.76646691
11DROSHA_22980978_ChIP-Seq_HELA_Human2.63645146
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60533790
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58892108
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54660158
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.52153351
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50956963
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50776915
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47614244
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.45605434
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40173412
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.34652352
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.34517069
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.22696440
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14078604
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13619714
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07426224
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04895230
28* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97175688
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90772170
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76138511
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69300558
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67995904
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64417743
34AR_21572438_ChIP-Seq_LNCaP_Human1.61685430
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.61172035
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60272739
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58119403
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53105820
39SMAD4_21799915_ChIP-Seq_A2780_Human1.52411793
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.51773865
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47822838
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46777296
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.43531430
44TAF15_26573619_Chip-Seq_HEK293_Human1.42428865
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41981549
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36318807
47ZNF274_21170338_ChIP-Seq_K562_Hela1.32511112
48RNF2_27304074_Chip-Seq_NSC_Mouse1.31046602
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29779009
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.28859602
51P300_19829295_ChIP-Seq_ESCs_Human1.26947123
52* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26604550
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24463187
54IGF1R_20145208_ChIP-Seq_DFB_Human1.22788055
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22526589
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.20922692
57AR_19668381_ChIP-Seq_PC3_Human1.18815957
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17333552
59STAT3_23295773_ChIP-Seq_U87_Human1.17069429
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.16086775
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15112465
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13618492
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12811132
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12518746
65AR_25329375_ChIP-Seq_VCAP_Human1.12496005
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.07941042
67* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07710094
68KDM2B_26808549_Chip-Seq_K562_Human1.06126943
69TCF4_23295773_ChIP-Seq_U87_Human1.05144912
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04963636
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.04426150
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03855017
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02451260
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02451260
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01507226
76* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00686741
77* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00363048
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97955031
79OCT4_19829295_ChIP-Seq_ESCs_Human0.97937188
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97637817
81RUNX2_22187159_ChIP-Seq_PCA_Human0.96261074
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95758083
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95468856
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95052692
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94821505
86* SMAD3_21741376_ChIP-Seq_ESCs_Human0.94284087
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.94111395
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93630827
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93125106
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92649242
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92026966
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91845863
93CTCF_27219007_Chip-Seq_Bcells_Human0.91683677
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90460012
95LXR_22292898_ChIP-Seq_THP-1_Human0.90451267
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.90265831
97SMAD_19615063_ChIP-ChIP_OVARY_Human0.89364840
98EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89316817
99AHR_22903824_ChIP-Seq_MCF-7_Human0.88970105
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88831308
101TP53_20018659_ChIP-ChIP_R1E_Mouse0.88355571
102NANOG_18555785_Chip-Seq_ESCs_Mouse0.88109999
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87680313
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87630469
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87248646
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87217189
107SMC4_20622854_ChIP-Seq_HELA_Human0.86409759
108ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85274546
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85122135
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83635474
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83451682
112RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83257840
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83198998
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82463509
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.81437337
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81368970
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79913630
118KLF4_19829295_ChIP-Seq_ESCs_Human0.79271807
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79230934
120DPY_21335234_ChIP-Seq_ESCs_Mouse0.78991091
121* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75870439
122SMAD4_21741376_ChIP-Seq_ESCs_Human0.75093468
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74726629
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74654453
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.74374755
126CREB1_26743006_Chip-Seq_LNCaP_Human0.71039000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.77886484
2MP0003880_abnormal_central_pattern4.36805374
3MP0003635_abnormal_synaptic_transmissio3.88983619
4MP0005423_abnormal_somatic_nervous3.38913945
5MP0004270_analgesia3.31181483
6MP0009745_abnormal_behavioral_response3.21840615
7MP0009046_muscle_twitch3.12708389
8MP0002063_abnormal_learning/memory/cond3.10939772
9MP0002064_seizures2.95081071
10MP0002822_catalepsy2.89074630
11MP0001968_abnormal_touch/_nociception2.70950998
12MP0002572_abnormal_emotion/affect_behav2.65647159
13MP0002272_abnormal_nervous_system2.63219825
14MP0002734_abnormal_mechanical_nocicepti2.62637850
15MP0001486_abnormal_startle_reflex2.62138306
16MP0001501_abnormal_sleep_pattern2.19334672
17MP0002735_abnormal_chemical_nociception2.17035315
18MP0003123_paternal_imprinting2.09846128
19MP0005645_abnormal_hypothalamus_physiol2.09665864
20MP0002184_abnormal_innervation2.06243832
21MP0002736_abnormal_nociception_after2.02085779
22MP0008569_lethality_at_weaning2.00926051
23MP0002733_abnormal_thermal_nociception1.98284192
24MP0001188_hyperpigmentation1.98110148
25MP0002067_abnormal_sensory_capabilities1.95177905
26MP0000778_abnormal_nervous_system1.94946046
27MP0001440_abnormal_grooming_behavior1.93570912
28MP0006276_abnormal_autonomic_nervous1.92437076
29MP0001970_abnormal_pain_threshold1.92222316
30MP0002557_abnormal_social/conspecific_i1.84871957
31MP0001984_abnormal_olfaction1.82529873
32MP0003787_abnormal_imprinting1.71938286
33MP0005551_abnormal_eye_electrophysiolog1.70950344
34MP0005646_abnormal_pituitary_gland1.65975170
35MP0004811_abnormal_neuron_physiology1.64720035
36MP0002909_abnormal_adrenal_gland1.62394373
37MP0000955_abnormal_spinal_cord1.61182492
38MP0004924_abnormal_behavior1.60430376
39MP0005386_behavior/neurological_phenoty1.60430376
40MP0001502_abnormal_circadian_rhythm1.57617741
41MP0002882_abnormal_neuron_morphology1.52819980
42MP0004142_abnormal_muscle_tone1.47699871
43MP0003879_abnormal_hair_cell1.45947270
44MP0006072_abnormal_retinal_apoptosis1.41718123
45MP0001529_abnormal_vocalization1.41270214
46MP0004885_abnormal_endolymph1.40433138
47MP0002638_abnormal_pupillary_reflex1.39262664
48MP0002066_abnormal_motor_capabilities/c1.38526037
49MP0003122_maternal_imprinting1.35691368
50MP0004858_abnormal_nervous_system1.35317722
51MP0009780_abnormal_chondrocyte_physiolo1.33010562
52MP0006292_abnormal_olfactory_placode1.27399611
53MP0005409_darkened_coat_color1.24128345
54MP0003121_genomic_imprinting1.22178497
55MP0010386_abnormal_urinary_bladder1.18566701
56MP0004742_abnormal_vestibular_system1.18377579
57MP0005499_abnormal_olfactory_system1.17173237
58MP0005394_taste/olfaction_phenotype1.17173237
59MP0000569_abnormal_digit_pigmentation1.14007280
60MP0002152_abnormal_brain_morphology1.13262464
61MP0008877_abnormal_DNA_methylation1.12570613
62MP0003633_abnormal_nervous_system1.12381960
63MP0003329_amyloid_beta_deposits1.11196605
64MP0004145_abnormal_muscle_electrophysio1.10150322
65MP0001348_abnormal_lacrimal_gland1.09469714
66MP0002229_neurodegeneration1.08760311
67MP0000631_abnormal_neuroendocrine_gland1.07142860
68MP0001905_abnormal_dopamine_level1.05057848
69MP0002752_abnormal_somatic_nervous1.03388561
70MP0005253_abnormal_eye_physiology1.01206493
71MP0008872_abnormal_physiological_respon0.98686367
72MP0003690_abnormal_glial_cell0.97124696
73MP0002069_abnormal_eating/drinking_beha0.96402047
74MP0003631_nervous_system_phenotype0.94465845
75MP0003283_abnormal_digestive_organ0.93118027
76MP0001963_abnormal_hearing_physiology0.88510209
77MP0004085_abnormal_heartbeat0.85125625
78MP0008961_abnormal_basal_metabolism0.84650239
79MP0002090_abnormal_vision0.78442538
80MP0000751_myopathy0.76980013
81MP0004043_abnormal_pH_regulation0.75316740
82MP0002876_abnormal_thyroid_physiology0.73896344
83MP0001485_abnormal_pinna_reflex0.73621077
84MP0004133_heterotaxia0.71507552
85MP0003634_abnormal_glial_cell0.71217343
86MP0005535_abnormal_body_temperature0.70028894
87MP0001177_atelectasis0.69289118
88MP0001299_abnormal_eye_distance/0.69057859
89MP0002102_abnormal_ear_morphology0.68465790
90MP0000013_abnormal_adipose_tissue0.67736238
91MP0003861_abnormal_nervous_system0.67412372
92MP0000026_abnormal_inner_ear0.67176787
93MP0005377_hearing/vestibular/ear_phenot0.67133095
94MP0003878_abnormal_ear_physiology0.67133095
95MP0003137_abnormal_impulse_conducting0.65962142
96MP0003632_abnormal_nervous_system0.65841699
97MP0001986_abnormal_taste_sensitivity0.65459312
98MP0008874_decreased_physiological_sensi0.65381377
99MP0001346_abnormal_lacrimal_gland0.65237928
100MP0003938_abnormal_ear_development0.64842011
101MP0009379_abnormal_foot_pigmentation0.64645935
102MP0002249_abnormal_larynx_morphology0.64634026
103MP0002234_abnormal_pharynx_morphology0.63943778
104MP0000566_synostosis0.63248232
105MP0002751_abnormal_autonomic_nervous0.61515549
106MP0008789_abnormal_olfactory_epithelium0.60811631
107MP0002082_postnatal_lethality0.59915976
108MP0010770_preweaning_lethality0.59915976
109MP0005195_abnormal_posterior_eye0.59474828
110MP0003119_abnormal_digestive_system0.59039451
111MP0000920_abnormal_myelination0.57600644
112MP0010768_mortality/aging0.57467791
113MP0000604_amyloidosis0.56439624
114MP0000579_abnormal_nail_morphology0.56164022
115MP0010769_abnormal_survival0.55651000
116MP0005167_abnormal_blood-brain_barrier0.55591373
117MP0001664_abnormal_digestion0.55554132
118MP0002653_abnormal_ependyma_morphology0.55060456
119MP0001943_abnormal_respiration0.54440171
120MP0005410_abnormal_fertilization0.54229050

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.78854050
2Myokymia (HP:0002411)6.57200390
3Focal seizures (HP:0007359)5.42489957
4Febrile seizures (HP:0002373)4.85060681
5Visual hallucinations (HP:0002367)4.79609957
6Epileptic encephalopathy (HP:0200134)4.78791291
7Progressive cerebellar ataxia (HP:0002073)4.73815528
8Atonic seizures (HP:0010819)4.13988617
9Action tremor (HP:0002345)3.97028581
10Absence seizures (HP:0002121)3.61772508
11Broad-based gait (HP:0002136)3.58686530
12Generalized tonic-clonic seizures (HP:0002069)3.58345112
13Supranuclear gaze palsy (HP:0000605)3.56527383
14Gaze-evoked nystagmus (HP:0000640)3.37001229
15Ankle clonus (HP:0011448)3.33096656
16Dialeptic seizures (HP:0011146)3.28259897
17Poor eye contact (HP:0000817)3.09270828
18Amblyopia (HP:0000646)3.02413159
19Dysdiadochokinesis (HP:0002075)3.00614737
20Anxiety (HP:0000739)2.94971695
21Depression (HP:0000716)2.93586326
22Cerebral hypomyelination (HP:0006808)2.93491894
23Hemiparesis (HP:0001269)2.88216476
24Truncal ataxia (HP:0002078)2.87871346
25Impaired vibration sensation in the lower limbs (HP:0002166)2.86905646
26Genetic anticipation (HP:0003743)2.85262896
27Abnormal eating behavior (HP:0100738)2.84031444
28Dysmetria (HP:0001310)2.77492679
29Cerebral inclusion bodies (HP:0100314)2.77261772
30Impaired social interactions (HP:0000735)2.75226058
31Abnormal social behavior (HP:0012433)2.75226058
32Impaired smooth pursuit (HP:0007772)2.68153356
33Urinary bladder sphincter dysfunction (HP:0002839)2.67931184
34Hyperventilation (HP:0002883)2.65533163
35Congenital stationary night blindness (HP:0007642)2.62635508
36Postural instability (HP:0002172)2.59834693
37Akinesia (HP:0002304)2.59309923
38Obstructive sleep apnea (HP:0002870)2.59188235
39Scanning speech (HP:0002168)2.57083373
40Mutism (HP:0002300)2.56122085
41Drooling (HP:0002307)2.55140767
42Excessive salivation (HP:0003781)2.55140767
43Epileptiform EEG discharges (HP:0011182)2.49733265
44Stereotypic behavior (HP:0000733)2.46368032
45Agitation (HP:0000713)2.46230378
46EEG with generalized epileptiform discharges (HP:0011198)2.45851810
47Spastic gait (HP:0002064)2.44347380
48Focal dystonia (HP:0004373)2.43715567
49Limb dystonia (HP:0002451)2.39333821
50Torticollis (HP:0000473)2.37643404
51Hemiplegia (HP:0002301)2.34585395
52Hypsarrhythmia (HP:0002521)2.31794719
53Abnormality of ocular smooth pursuit (HP:0000617)2.27956132
54Diplopia (HP:0000651)2.27177465
55Abnormality of binocular vision (HP:0011514)2.27177465
56Peripheral hypomyelination (HP:0007182)2.19707395
57Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18716165
58Insomnia (HP:0100785)2.16854624
59Intention tremor (HP:0002080)2.16752327
60Absent speech (HP:0001344)2.15874266
61Morphological abnormality of the pyramidal tract (HP:0002062)2.15725547
62Central scotoma (HP:0000603)2.15217456
63Failure to thrive in infancy (HP:0001531)2.14913554
64Apathy (HP:0000741)2.13165275
65Delusions (HP:0000746)2.13091392
66Bradykinesia (HP:0002067)2.12415133
67Abnormality of the lower motor neuron (HP:0002366)2.10942347
68Craniofacial dystonia (HP:0012179)2.10622677
69Spastic tetraparesis (HP:0001285)2.10328202
70Ventricular fibrillation (HP:0001663)2.10029762
71Polyphagia (HP:0002591)2.09424328
72Urinary urgency (HP:0000012)2.07798271
73Progressive inability to walk (HP:0002505)2.07091652
74Tetraplegia (HP:0002445)2.05852375
75Abnormality of the corticospinal tract (HP:0002492)2.05366597
76Megalencephaly (HP:0001355)2.05132231
77Pointed chin (HP:0000307)2.02569088
78Gait imbalance (HP:0002141)2.01862978
79Fetal akinesia sequence (HP:0001989)2.00111563
80Specific learning disability (HP:0001328)1.99988907
81Impaired vibratory sensation (HP:0002495)1.98351386
82Status epilepticus (HP:0002133)1.96319825
83Neuronal loss in central nervous system (HP:0002529)1.95998457
84Spastic tetraplegia (HP:0002510)1.95800920
85Abnormality of macular pigmentation (HP:0008002)1.95535815
86Decreased central vision (HP:0007663)1.93151398
87Abnormal EKG (HP:0003115)1.92122178
88Psychosis (HP:0000709)1.91091158
89Lower limb muscle weakness (HP:0007340)1.91079894
90Diminished motivation (HP:0000745)1.90290777
91Turricephaly (HP:0000262)1.90023942
92Papilledema (HP:0001085)1.88191916
93Protruding tongue (HP:0010808)1.87264080
94Rigidity (HP:0002063)1.84218595
95Abnormal rod and cone electroretinograms (HP:0008323)1.83104454
96CNS hypomyelination (HP:0003429)1.81821047
97Esotropia (HP:0000565)1.81276656
98Bony spicule pigmentary retinopathy (HP:0007737)1.79492294
99Autism (HP:0000717)1.79438499
100Prolonged QT interval (HP:0001657)1.79238969
101Abnormality of salivation (HP:0100755)1.78280712
102Incomplete penetrance (HP:0003829)1.78132348
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77549858
104Choreoathetosis (HP:0001266)1.76048741
105Neurofibrillary tangles (HP:0002185)1.74943959
106Degeneration of the lateral corticospinal tracts (HP:0002314)1.74884916
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74884916
108Abnormality of calcium-phosphate metabolism (HP:0100530)1.74244191
109Hypoventilation (HP:0002791)1.74075196
110Inability to walk (HP:0002540)1.73849957
111Sleep apnea (HP:0010535)1.71677010
112Clonus (HP:0002169)1.71494608
113Hypoplasia of the corpus callosum (HP:0002079)1.71323133
114Annular pancreas (HP:0001734)1.71140462
115Postural tremor (HP:0002174)1.71033097
116Aplasia involving bones of the extremities (HP:0009825)1.70750448
117Aplasia involving bones of the upper limbs (HP:0009823)1.70750448
118Aplasia of the phalanges of the hand (HP:0009802)1.70750448
119Gait ataxia (HP:0002066)1.70538645
120Anosmia (HP:0000458)1.69565611
121Pheochromocytoma (HP:0002666)1.69535594
122Dysmetric saccades (HP:0000641)1.69196917
123Exotropia (HP:0000577)1.68660867
124Unsteady gait (HP:0002317)1.68614230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.45758821
2EPHA43.96588351
3MARK13.57542497
4MAP3K93.37279692
5MAP3K42.81156514
6NTRK22.64693964
7MAP2K72.60956420
8MINK12.49192520
9DAPK22.43937203
10PAK62.33033181
11CASK2.09191344
12TNIK2.08662569
13PRPF4B1.81364258
14MAPK131.75969179
15UHMK11.66576919
16CAMKK11.65947438
17SIK21.65673608
18KSR11.64387585
19MAP2K41.63719528
20PRKD31.59926828
21RIPK41.58429430
22CDK51.56687572
23CDK191.54783049
24NTRK11.50432620
25DYRK21.32990974
26STK381.30560499
27CAMKK21.24205850
28KSR21.23581481
29FES1.23302055
30PRKCG1.23241523
31DAPK11.21806845
32MAP3K121.21620641
33GRK51.20179012
34SGK4941.15668876
35SGK2231.15668876
36STK111.10169933
37PHKG21.09578226
38PHKG11.09578226
39PLK21.05859084
40CAMK11.04705967
41DYRK1A1.03323136
42PINK11.01675838
43PNCK1.00215277
44CAMK2A0.93490235
45SGK20.93278275
46INSRR0.92355033
47MARK20.92031296
48TAOK10.90388627
49CDK180.87754976
50CDK150.86950482
51CDC42BPA0.85597836
52MAP3K20.84193178
53CAMK2B0.83451051
54RIPK10.81587946
55TYRO30.81367730
56FGFR20.80124655
57TNK20.80070152
58CDK140.79482540
59MAP3K130.78637483
60PAK30.77846550
61CDK11A0.77714034
62WNK10.77301049
63SGK10.76939916
64TRIB30.76467023
65PRKCH0.76354934
66WNK30.72899475
67SGK30.70419072
68ARAF0.68455798
69OXSR10.68375617
70AKT30.68195542
71LIMK10.67713502
72ALK0.67434562
73BMPR20.64536753
74CAMK40.61778865
75PRKCZ0.60668316
76ICK0.59428575
77CSNK1G20.58041605
78CAMK1D0.57762979
79NEK60.57329047
80BRSK10.56281493
81CAMK2D0.55881367
82MAPK120.55873571
83MAP3K110.55590099
84CAMK1G0.52983680
85RPS6KA20.52461002
86RPS6KA30.52080664
87DMPK0.51266804
88RET0.50981108
89PRKCE0.50712026
90PKN10.49751884
91LMTK20.48351162
92CSNK1E0.47438743
93TESK10.46783217
94MAPK100.46039842
95FYN0.45749783
96DYRK1B0.45664598
97NME10.45210556
98IRAK20.43486701
99BRAF0.43000818
100CAMK2G0.41729578
101MAPK80.40926804
102BCR0.40607060
103PDPK10.39864496
104PRKCB0.39743099
105RAF10.39088845
106ERBB20.38827559
107DAPK30.37607486
108PRKACA0.37491141
109PDK10.37341031
110PRKG10.37153144
111PRKD20.36538338
112LATS20.35739770
113FGR0.35670873
114CDK30.34858875
115MAP3K60.34651948
116FER0.34395217
117GSK3B0.34358484
118PRKAA10.33551621
119ROCK20.32876890
120CSNK1D0.32187295
121CSNK1G30.32076770
122PRKCA0.31942646

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97107148
2Synaptic vesicle cycle_Homo sapiens_hsa047213.30483790
3GABAergic synapse_Homo sapiens_hsa047272.87711183
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.83803432
5Circadian entrainment_Homo sapiens_hsa047132.81905142
6Olfactory transduction_Homo sapiens_hsa047402.79126195
7Glutamatergic synapse_Homo sapiens_hsa047242.74366020
8Morphine addiction_Homo sapiens_hsa050322.71104531
9Long-term potentiation_Homo sapiens_hsa047202.47407702
10Amphetamine addiction_Homo sapiens_hsa050312.32726256
11Insulin secretion_Homo sapiens_hsa049112.25148181
12Taste transduction_Homo sapiens_hsa047422.18123138
13Dopaminergic synapse_Homo sapiens_hsa047282.17983025
14Salivary secretion_Homo sapiens_hsa049702.11043569
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10286735
16Cholinergic synapse_Homo sapiens_hsa047252.04392921
17Phototransduction_Homo sapiens_hsa047441.96958334
18Long-term depression_Homo sapiens_hsa047301.88550833
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87708716
20Serotonergic synapse_Homo sapiens_hsa047261.86324532
21Gastric acid secretion_Homo sapiens_hsa049711.73466424
22Cocaine addiction_Homo sapiens_hsa050301.70775754
23Oxytocin signaling pathway_Homo sapiens_hsa049211.63011164
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61709680
25Calcium signaling pathway_Homo sapiens_hsa040201.61012440
26Renin secretion_Homo sapiens_hsa049241.58728390
27GnRH signaling pathway_Homo sapiens_hsa049121.43502573
28Type II diabetes mellitus_Homo sapiens_hsa049301.38997417
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36117861
30Gap junction_Homo sapiens_hsa045401.33280615
31cAMP signaling pathway_Homo sapiens_hsa040241.26613938
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25966272
33Collecting duct acid secretion_Homo sapiens_hsa049661.22680363
34Axon guidance_Homo sapiens_hsa043601.22559464
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22516895
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20625038
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20323935
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15329278
39Cardiac muscle contraction_Homo sapiens_hsa042601.13584984
40Vitamin B6 metabolism_Homo sapiens_hsa007501.12551870
41Estrogen signaling pathway_Homo sapiens_hsa049151.06574393
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04558256
43Melanogenesis_Homo sapiens_hsa049161.01695541
44ErbB signaling pathway_Homo sapiens_hsa040121.00177224
45Glioma_Homo sapiens_hsa052140.96535726
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.94036469
47Pancreatic secretion_Homo sapiens_hsa049720.89372680
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85928392
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85915303
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82166940
51Vibrio cholerae infection_Homo sapiens_hsa051100.81704712
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.80919973
53Circadian rhythm_Homo sapiens_hsa047100.76973130
54Dilated cardiomyopathy_Homo sapiens_hsa054140.75329281
55MAPK signaling pathway_Homo sapiens_hsa040100.74525658
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73259366
57Thyroid hormone synthesis_Homo sapiens_hsa049180.72106760
58Alcoholism_Homo sapiens_hsa050340.71172540
59Choline metabolism in cancer_Homo sapiens_hsa052310.69411440
60Oocyte meiosis_Homo sapiens_hsa041140.69201213
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67468775
62Inositol phosphate metabolism_Homo sapiens_hsa005620.65398378
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64999181
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63561036
65Dorso-ventral axis formation_Homo sapiens_hsa043200.60866702
66Ras signaling pathway_Homo sapiens_hsa040140.57536623
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56854495
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.56073241
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54992767
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54930345
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54174649
72Wnt signaling pathway_Homo sapiens_hsa043100.53822598
73Type I diabetes mellitus_Homo sapiens_hsa049400.53644456
74Alzheimers disease_Homo sapiens_hsa050100.50640890
75Fatty acid biosynthesis_Homo sapiens_hsa000610.49512197
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.49137941
77Rap1 signaling pathway_Homo sapiens_hsa040150.49046745
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49009565
79VEGF signaling pathway_Homo sapiens_hsa043700.46862186
80Glucagon signaling pathway_Homo sapiens_hsa049220.46594940
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45185859
82Arginine and proline metabolism_Homo sapiens_hsa003300.44909271
83mTOR signaling pathway_Homo sapiens_hsa041500.44093282
84Endometrial cancer_Homo sapiens_hsa052130.43485757
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43237986
86Ovarian steroidogenesis_Homo sapiens_hsa049130.41673843
87AMPK signaling pathway_Homo sapiens_hsa041520.41273953
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41211783
89Hippo signaling pathway_Homo sapiens_hsa043900.40337506
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40264440
91Chemokine signaling pathway_Homo sapiens_hsa040620.36180191
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35519815
93Endocytosis_Homo sapiens_hsa041440.35264873
94Tight junction_Homo sapiens_hsa045300.35041807
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34947634
96Non-small cell lung cancer_Homo sapiens_hsa052230.34907671
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34753660
98Renal cell carcinoma_Homo sapiens_hsa052110.34392446
99Bile secretion_Homo sapiens_hsa049760.33556960
100Prion diseases_Homo sapiens_hsa050200.32429872
101Insulin signaling pathway_Homo sapiens_hsa049100.30230599
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29518656
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28714540
104Hedgehog signaling pathway_Homo sapiens_hsa043400.28384390
105African trypanosomiasis_Homo sapiens_hsa051430.26825753
106Mineral absorption_Homo sapiens_hsa049780.26235111
107Colorectal cancer_Homo sapiens_hsa052100.26085564
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25609318
109Regulation of autophagy_Homo sapiens_hsa041400.24474051
110Oxidative phosphorylation_Homo sapiens_hsa001900.23953035
111ABC transporters_Homo sapiens_hsa020100.23748981
112Prolactin signaling pathway_Homo sapiens_hsa049170.21778058

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