SRRM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA packaging (GO:0006323)9.60289341
2response to pheromone (GO:0019236)9.47332368
3sperm capacitation (GO:0048240)9.42276592
4single strand break repair (GO:0000012)8.66192532
5spermatid nucleus differentiation (GO:0007289)8.55596264
6plasma membrane fusion (GO:0045026)8.52678472
7microtubule depolymerization (GO:0007019)8.46112695
8spermatid development (GO:0007286)8.08344548
9sperm-egg recognition (GO:0035036)7.62112310
10sexual reproduction (GO:0019953)7.30338436
11binding of sperm to zona pellucida (GO:0007339)7.19012019
12rRNA methylation (GO:0031167)7.12379537
13multicellular organism reproduction (GO:0032504)6.99907489
14microtubule polymerization or depolymerization (GO:0031109)6.87581975
15negative regulation of inclusion body assembly (GO:0090084)6.84511415
16reproduction (GO:0000003)6.83285130
17protein polyglutamylation (GO:0018095)6.64481494
18calcium ion-dependent exocytosis (GO:0017156)6.63237552
19protein targeting to Golgi (GO:0000042)6.51580785
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.32547103
21cell-cell recognition (GO:0009988)6.26249510
22establishment of protein localization to Golgi (GO:0072600)6.24845749
23spermatogenesis (GO:0007283)6.15011794
24axonemal dynein complex assembly (GO:0070286)6.13708896
25male gamete generation (GO:0048232)6.12920859
26retrograde transport, vesicle recycling within Golgi (GO:0000301)6.07617954
27rRNA modification (GO:0000154)5.98880010
28phosphatidylethanolamine metabolic process (GO:0046337)5.81994665
29microtubule severing (GO:0051013)5.76479231
30cellular ketone body metabolic process (GO:0046950)5.75376567
31gamete generation (GO:0007276)5.60609917
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60556073
33centriole replication (GO:0007099)5.25536388
34regulation of Rab GTPase activity (GO:0032313)5.19945473
35positive regulation of Rab GTPase activity (GO:0032851)5.19945473
36chromatin silencing (GO:0006342)5.09386120
37ketone body metabolic process (GO:1902224)5.06659292
38motile cilium assembly (GO:0044458)4.95328255
39single fertilization (GO:0007338)4.93185235
40regulation of cilium movement (GO:0003352)4.90793150
41regulation of inclusion body assembly (GO:0090083)4.89787244
42centriole assembly (GO:0098534)4.69940929
43protein localization to Golgi apparatus (GO:0034067)4.69427727
44germ cell development (GO:0007281)4.59062890
45cilium or flagellum-dependent cell motility (GO:0001539)4.58085747
46RNA destabilization (GO:0050779)4.54272858
47multicellular organismal reproductive process (GO:0048609)4.49572774
48cell wall macromolecule catabolic process (GO:0016998)4.46156219
49regulation of transcription involved in cell fate commitment (GO:0060850)4.40252850
50cellular process involved in reproduction in multicellular organism (GO:0022412)4.39236465
51regulation of centriole replication (GO:0046599)4.36388305
52nucleus organization (GO:0006997)4.35145622
53cell wall macromolecule metabolic process (GO:0044036)4.20339337
54fertilization (GO:0009566)4.05294270
55seminiferous tubule development (GO:0072520)4.04000857
56coenzyme catabolic process (GO:0009109)4.02171518
57negative regulation of Rho protein signal transduction (GO:0035024)3.88065095
58glycerol ether metabolic process (GO:0006662)3.87648934
59epithelial cilium movement (GO:0003351)3.74311176
60musculoskeletal movement (GO:0050881)3.58506469
61multicellular organismal movement (GO:0050879)3.58506469
62protein-DNA complex disassembly (GO:0032986)3.57184832
63nucleosome disassembly (GO:0006337)3.57184832
64ether metabolic process (GO:0018904)3.56595360
65negative regulation of gene expression, epigenetic (GO:0045814)3.53319811
66cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.49725795
67glomerular visceral epithelial cell development (GO:0072015)3.46429896
68organic cation transport (GO:0015695)3.44780925
69response to acidic pH (GO:0010447)3.39387490
70histone H3-K9 demethylation (GO:0033169)3.36899514
71polyamine biosynthetic process (GO:0006596)3.36248903
72peptidyl-threonine dephosphorylation (GO:0035970)3.34827597
73glomerular epithelial cell development (GO:0072310)3.34738046
74cilium movement (GO:0003341)3.31815903
75regulation of interleukin-13 production (GO:0032656)3.29616348
76cerebral cortex neuron differentiation (GO:0021895)3.28289275
77regulation of microtubule-based movement (GO:0060632)3.26491609
78protein depolymerization (GO:0051261)3.23724451
79DNA conformation change (GO:0071103)3.21079817
80mesenchymal cell differentiation involved in renal system development (GO:2001012)3.20710375
81mesenchymal cell differentiation involved in kidney development (GO:0072161)3.20710375
82regulation of T-helper 2 cell differentiation (GO:0045628)3.19831147
83cellular response to pH (GO:0071467)3.19713193
84membrane protein intracellular domain proteolysis (GO:0031293)3.14922421
85homeostasis of number of cells within a tissue (GO:0048873)3.11827032
86microtubule nucleation (GO:0007020)3.07603216
87cranial nerve morphogenesis (GO:0021602)3.06814159
88cell differentiation involved in metanephros development (GO:0072202)3.04071727
89multicellular organismal development (GO:0007275)3.00620630
90cell recognition (GO:0008037)2.99220884
91negative regulation of histone methylation (GO:0031061)2.95187368
92NAD biosynthetic process (GO:0009435)2.84838736
93regulation of somitogenesis (GO:0014807)2.81923603
94regulation of ARF GTPase activity (GO:0032312)2.80151838
95mitotic G1 DNA damage checkpoint (GO:0031571)2.79916579
96peptidyl-proline hydroxylation (GO:0019511)2.77381423
97acrosome reaction (GO:0007340)12.3706405
98sperm motility (GO:0030317)11.6880911
99fusion of sperm to egg plasma membrane (GO:0007342)11.2662048
100chromosome condensation (GO:0030261)10.0481069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.90763186
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.17646182
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.95342808
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35937564
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.35937564
6ELF1_20517297_ChIP-Seq_JURKAT_Human2.32224449
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13434141
8CBP_20019798_ChIP-Seq_JUKART_Human2.09830454
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.09830454
10ERA_21632823_ChIP-Seq_H3396_Human2.09404775
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.08887903
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00515381
13RAC3_21632823_ChIP-Seq_H3396_Human2.00352328
14RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.91963512
15EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.91685019
16EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.88841679
17DROSHA_22980978_ChIP-Seq_HELA_Human1.88746195
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87984477
19NANOG_20526341_ChIP-Seq_ESCs_Human1.85924338
20BCL6_27268052_Chip-Seq_Bcells_Human1.83598438
21WDR5_24793694_ChIP-Seq_LNCAP_Human1.80599260
22* CTCF_27219007_Chip-Seq_Bcells_Human1.79791100
23SMC4_20622854_ChIP-Seq_HELA_Human1.79031275
24P68_20966046_ChIP-Seq_HELA_Human1.75830214
25YY1_22570637_ChIP-Seq_MALME-3M_Human1.74471458
26BCOR_27268052_Chip-Seq_Bcells_Human1.73670047
27FUS_26573619_Chip-Seq_HEK293_Human1.70721640
28LXR_22292898_ChIP-Seq_THP-1_Human1.69126817
29* E2F1_20622854_ChIP-Seq_HELA_Human1.68621665
30TDRD3_21172665_ChIP-Seq_MCF-7_Human1.68180891
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66252206
32TAF2_19829295_ChIP-Seq_ESCs_Human1.64292187
33MYC_19829295_ChIP-Seq_ESCs_Human1.60512955
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57516602
35EZH2_22144423_ChIP-Seq_EOC_Human1.56758531
36* PHF8_20622854_ChIP-Seq_HELA_Human1.55749170
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55032429
38* TP63_22573176_ChIP-Seq_HFKS_Human1.54807125
39OCT4_20526341_ChIP-Seq_ESCs_Human1.51188830
40* CTCF_20526341_ChIP-Seq_ESCs_Human1.50342591
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49800849
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49097740
43ER_23166858_ChIP-Seq_MCF-7_Human1.48026205
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.45965199
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45377732
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44691567
47P300_27268052_Chip-Seq_Bcells_Human1.42846041
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.40645442
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38370733
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.36043986
51HNFA_21074721_ChIP-Seq_CACO-2_Human1.35981645
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34544728
53TP53_18474530_ChIP-ChIP_U2OS_Human1.33971229
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.33657116
55RBPJ_21746931_ChIP-Seq_IB4_Human1.31876977
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.31177745
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30410596
58AR_25329375_ChIP-Seq_VCAP_Human1.29478317
59P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.29439888
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27380840
61ERG_20517297_ChIP-Seq_VCAP_Human1.26076903
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25987570
63ETV1_20927104_ChIP-Seq_GIST48_Human1.24896978
64SA1_27219007_Chip-Seq_Bcells_Human1.24010234
65SMAD3_21741376_ChIP-Seq_ESCs_Human1.23400862
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22610517
67CEBPB_22108803_ChIP-Seq_LS180_Human1.22388612
68P53_21459846_ChIP-Seq_SAOS-2_Human1.21063150
69RUNX_20019798_ChIP-Seq_JUKART_Human1.20383731
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19620093
71NFYB_21822215_ChIP-Seq_K562_Human1.15499779
72* GATA3_21878914_ChIP-Seq_MCF-7_Human1.14988250
73RUNX1_26923725_Chip-Seq_HPCs_Mouse1.14772982
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14462404
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.12897507
76TBL1_22424771_ChIP-Seq_293T_Human1.11539706
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10595394
78SMRT_27268052_Chip-Seq_Bcells_Human1.09188380
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08216778
80SMAD4_21741376_ChIP-Seq_HESCs_Human1.07956638
81TAF15_26573619_Chip-Seq_HEK293_Human1.07789589
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.07246594
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07038610
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.06978499
85PHF8_20622853_ChIP-Seq_HELA_Human1.06651520
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.06510529
87FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03264580
88E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02273135
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.01724446
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01036445
91KLF5_25053715_ChIP-Seq_YYC3_Human1.00875822
92CSB_26484114_Chip-Seq_FIBROBLAST_Human1.00751835
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00610624
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00460217
95P300_19829295_ChIP-Seq_ESCs_Human1.00253988
96OCT4_19829295_ChIP-Seq_ESCs_Human0.99406479
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98780550
98KLF4_19829295_ChIP-Seq_ESCs_Human0.97634099
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97047742
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96466142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.02945745
2MP0003878_abnormal_ear_physiology5.02945745
3MP0005670_abnormal_white_adipose4.61438450
4MP0003698_abnormal_male_reproductive4.50866558
5MP0001348_abnormal_lacrimal_gland3.89747411
6MP0001929_abnormal_gametogenesis3.89672965
7MP0000678_abnormal_parathyroid_gland2.76065588
8MP0002161_abnormal_fertility/fecundity2.53352697
9MP0003011_delayed_dark_adaptation2.35533471
10MP0003718_maternal_effect2.19712771
11MP0002132_abnormal_respiratory_system2.13682250
12MP0005410_abnormal_fertilization12.6461977
13MP0003646_muscle_fatigue1.91910395
14MP0002249_abnormal_larynx_morphology1.78101419
15MP0005423_abnormal_somatic_nervous1.75756539
16MP0005379_endocrine/exocrine_gland_phen1.74605946
17MP0002210_abnormal_sex_determination1.66160780
18MP0002234_abnormal_pharynx_morphology1.65899491
19MP0004510_myositis1.52552618
20MP0002282_abnormal_trachea_morphology1.47277723
21MP0005310_abnormal_salivary_gland1.46379100
22MP0009053_abnormal_anal_canal1.45631750
23MP0001145_abnormal_male_reproductive1.37353006
24MP0001486_abnormal_startle_reflex1.36757507
25MP0001485_abnormal_pinna_reflex1.32684542
26MP0000653_abnormal_sex_gland1.28916608
27MP0000534_abnormal_ureter_morphology1.25141078
28MP0004742_abnormal_vestibular_system1.22072679
29MP0001765_abnormal_ion_homeostasis1.19837993
30MP0002735_abnormal_chemical_nociception1.19634660
31MP0002138_abnormal_hepatobiliary_system1.17967520
32MP0001968_abnormal_touch/_nociception1.17755953
33MP0005451_abnormal_body_composition1.16589770
34MP0004859_abnormal_synaptic_plasticity1.16143734
35MP0005248_abnormal_Harderian_gland1.14183338
36MP0002127_abnormal_cardiovascular_syste1.13962154
37MP0003879_abnormal_hair_cell1.05728122
38MP0002822_catalepsy1.04814446
39MP0001963_abnormal_hearing_physiology1.03191670
40MP0005395_other_phenotype1.00514406
41MP0000026_abnormal_inner_ear0.94264347
42MP0000681_abnormal_thyroid_gland0.91116566
43MP0005666_abnormal_adipose_tissue0.85093498
44MP0002229_neurodegeneration0.82810671
45MP0009115_abnormal_fat_cell0.81185673
46MP0005083_abnormal_biliary_tract0.81015782
47MP0000955_abnormal_spinal_cord0.78827464
48MP0000049_abnormal_middle_ear0.76173894
49MP0000516_abnormal_urinary_system0.75671606
50MP0005367_renal/urinary_system_phenotyp0.75671606
51MP0002733_abnormal_thermal_nociception0.73418594
52MP0005375_adipose_tissue_phenotype0.73132657
53MP0008569_lethality_at_weaning0.68976548
54MP0002067_abnormal_sensory_capabilities0.66602201
55MP0005551_abnormal_eye_electrophysiolog0.65228351
56MP0004233_abnormal_muscle_weight0.63951685
57MP0004085_abnormal_heartbeat0.63846600
58MP0001879_abnormal_lymphatic_vessel0.63738235
59MP0000003_abnormal_adipose_tissue0.61320494
60MP0008877_abnormal_DNA_methylation0.61144569
61MP0005636_abnormal_mineral_homeostasis0.60262192
62MP0001666_abnormal_nutrient_absorption0.59609656
63MP0003077_abnormal_cell_cycle0.59455908
64MP0002557_abnormal_social/conspecific_i0.58555697
65MP0005623_abnormal_meninges_morphology0.55193894
66MP0005253_abnormal_eye_physiology0.54649514
67MP0005167_abnormal_blood-brain_barrier0.53861176
68MP0009697_abnormal_copulation0.50815717
69MP0008995_early_reproductive_senescence0.50718830
70MP0004484_altered_response_of0.49673246
71MP0002572_abnormal_emotion/affect_behav0.48344158
72MP0001905_abnormal_dopamine_level0.46664979
73MP0008961_abnormal_basal_metabolism0.46259919
74MP0005535_abnormal_body_temperature0.45425449
75MP0001970_abnormal_pain_threshold0.45244880
76MP0003091_abnormal_cell_migration0.44042445
77MP0003119_abnormal_digestive_system0.43575359
78MP0000470_abnormal_stomach_morphology0.43473187
79MP0003699_abnormal_female_reproductive0.42417342
80MP0002928_abnormal_bile_duct0.41983701
81MP0000249_abnormal_blood_vessel0.40262241
82MP0003137_abnormal_impulse_conducting0.39198545
83MP0002734_abnormal_mechanical_nocicepti0.37644370
84MP0000613_abnormal_salivary_gland0.37593668
85MP0002254_reproductive_system_inflammat0.37232981
86MP0003172_abnormal_lysosome_physiology0.36786019
87MP0002272_abnormal_nervous_system0.35882590
88MP0001270_distended_abdomen0.35456251
89MP0004036_abnormal_muscle_relaxation0.35139104
90MP0002653_abnormal_ependyma_morphology0.34013437
91MP0005408_hypopigmentation0.33702620
92MP0003936_abnormal_reproductive_system0.33062692
93MP0001440_abnormal_grooming_behavior0.32752030
94MP0001984_abnormal_olfaction0.32409857
95MP0000467_abnormal_esophagus_morphology0.32354250
96MP0000566_synostosis0.31897392
97MP0009745_abnormal_behavioral_response0.31427557
98MP0006292_abnormal_olfactory_placode0.31150366
99MP0001873_stomach_inflammation0.30299267
100MP0003942_abnormal_urinary_system0.29249296

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.65656677
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.95400664
3Absent/shortened dynein arms (HP:0200106)5.95400664
4Asymmetric septal hypertrophy (HP:0001670)5.43620573
5Attenuation of retinal blood vessels (HP:0007843)5.33927437
6Bony spicule pigmentary retinopathy (HP:0007737)5.30874057
7Tubulointerstitial nephritis (HP:0001970)4.68270573
8Resting tremor (HP:0002322)4.59795199
9Abnormal ciliary motility (HP:0012262)4.53287845
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.48025808
11Abnormal respiratory motile cilium physiology (HP:0012261)4.42885263
12Bell-shaped thorax (HP:0001591)4.39674830
13Abnormal respiratory epithelium morphology (HP:0012253)4.36189268
14Abnormal respiratory motile cilium morphology (HP:0005938)4.36189268
15Male infertility (HP:0003251)4.34002240
16Nasal polyposis (HP:0100582)4.32056379
17Hyperkalemia (HP:0002153)4.30481995
18Infertility (HP:0000789)4.24850805
19Chronic hepatic failure (HP:0100626)4.21891148
20Abnormal rod and cone electroretinograms (HP:0008323)4.09949597
21Hypoplastic ischia (HP:0003175)4.00600806
22Facial shape deformation (HP:0011334)3.95245004
23Potter facies (HP:0002009)3.95245004
24Enlarged epiphyses (HP:0010580)3.92232482
25Abnormality of macular pigmentation (HP:0008002)3.88421450
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.67339518
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.64392361
28Cone-rod dystrophy (HP:0000548)3.58260277
29Abnormality of the ischium (HP:0003174)3.56414791
30Azoospermia (HP:0000027)3.51771124
31Abnormality of the nasal mucosa (HP:0000433)3.50162703
32Abnormal spermatogenesis (HP:0008669)3.45290256
33Impulsivity (HP:0100710)3.31401097
34Unilateral renal agenesis (HP:0000122)3.28889074
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.22285427
36Hypoplasia of the thymus (HP:0000778)3.13175012
37Progressive sensorineural hearing impairment (HP:0000408)3.07328628
38Congenital malformation of the right heart (HP:0011723)2.90860154
39Double outlet right ventricle (HP:0001719)2.90860154
40Postural instability (HP:0002172)2.87417834
41Abnormality of the aortic arch (HP:0012303)2.86391141
42Hypoalphalipoproteinemia (HP:0003233)2.84150821
43Abnormal urine output (HP:0012590)2.67446643
44Renal dysplasia (HP:0000110)2.65152852
45Generalized aminoaciduria (HP:0002909)2.64111627
46Truncal obesity (HP:0001956)2.62898207
47Stage 5 chronic kidney disease (HP:0003774)2.61837787
48Rhinitis (HP:0012384)2.55439969
49Abnormality of the costochondral junction (HP:0000919)2.50481348
50Amelogenesis imperfecta (HP:0000705)2.45787818
51Abnormality of potassium homeostasis (HP:0011042)2.45772240
52Progressive cerebellar ataxia (HP:0002073)2.41734434
53Abnormality of dental color (HP:0011073)2.40565021
54Flattened epiphyses (HP:0003071)2.39324377
55Abnormality of the parathyroid morphology (HP:0011766)2.38185354
56Renovascular hypertension (HP:0100817)2.37885205
57Nephronophthisis (HP:0000090)2.36571702
58Portal hypertension (HP:0001409)2.28861671
59Abnormality of renal excretion (HP:0011036)2.28348213
60Menstrual irregularities (HP:0000858)2.26225159
61Insulin-resistant diabetes mellitus (HP:0000831)2.23442477
62Ventricular tachycardia (HP:0004756)2.23415321
63Epiphyseal dysplasia (HP:0002656)2.19251346
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.19030369
65Absent epiphyses (HP:0010577)2.19030369
66Abnormality of the hepatic vasculature (HP:0006707)2.14230497
67Polydipsia (HP:0001959)2.12633089
68Abnormal drinking behavior (HP:0030082)2.12633089
69Osteomalacia (HP:0002749)2.12284703
70Widely patent fontanelles and sutures (HP:0004492)2.12102668
71Tubulointerstitial abnormality (HP:0001969)2.11268405
72Hyponatremia (HP:0002902)2.10354898
73Abnormality of the epiphysis of the femoral head (HP:0010574)2.08720829
74Polyuria (HP:0000103)2.06247799
75Hypophosphatemic rickets (HP:0004912)2.02302931
76Abnormality of the renal medulla (HP:0100957)2.01635866
77Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01018629
78Focal segmental glomerulosclerosis (HP:0000097)2.00912806
79Progressive hearing impairment (HP:0001730)2.00156966
80Abnormality of the pubic bones (HP:0003172)1.99659829
81Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.95510603
82Abnormality of femoral epiphyses (HP:0006499)1.95510603
83Bronchiectasis (HP:0002110)1.95184378
84Spastic paraparesis (HP:0002313)1.94656384
85Hypoparathyroidism (HP:0000829)1.93085356
86Decreased central vision (HP:0007663)1.93070206
87Sensory axonal neuropathy (HP:0003390)1.92895274
88Tetany (HP:0001281)1.91170584
89Hyperthyroidism (HP:0000836)1.90571278
90Abnormal ventriculo-arterial connection (HP:0011563)1.89734544
91Transposition of the great arteries (HP:0001669)1.89734544
92Abnormal connection of the cardiac segments (HP:0011545)1.89734544
93Atelectasis (HP:0100750)1.85871324
94Abnormality of the femoral head (HP:0003368)1.85167231
95Chronic bronchitis (HP:0004469)1.83854077
96Bradycardia (HP:0001662)1.83350184
97Flat capital femoral epiphysis (HP:0003370)1.81005997
98Bowel incontinence (HP:0002607)1.78668610
99Recurrent pneumonia (HP:0006532)1.78494102
100Intellectual disability, moderate (HP:0002342)1.77407453

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.37806072
2TESK16.25142775
3DDR25.07898239
4INSRR3.91152913
5MAP4K23.80403331
6BRD43.24383164
7STK383.15721859
8PLK22.99349441
9PNCK2.69037126
10MAPK152.42430408
11CAMK1G2.31731492
12PRKD32.28181175
13STK38L2.06029785
14MST1R1.92843597
15WNK11.92419944
16CDK121.71361162
17PIK3CG1.70514462
18PDPK11.66723650
19PDK11.52684773
20DYRK1B1.40274077
21CDK71.38683191
22NEK61.24585250
23KSR21.19799204
24MAP3K91.13072382
25PTK2B1.04339478
26CAMK1D0.99489766
27LATS20.97192427
28AKT30.80377532
29MAP3K110.79110631
30SIK20.78990461
31UHMK10.76719196
32BRAF0.75548776
33RPS6KA20.73100790
34PRKAA20.70534247
35TYRO30.67607048
36PRKG20.66544109
37MAP2K20.65049479
38MAP3K20.64553909
39MAP3K80.62816746
40RPS6KA10.61805585
41PRKG10.61403863
42WNK40.61317304
43MUSK0.53637795
44CDK40.52908621
45ROCK10.49090164
46CAMK10.48946860
47CDK30.47936668
48CDK20.47408236
49MTOR0.47331385
50GSK3B0.47267721
51CDK10.43548218
52TESK20.43308873
53RPS6KL10.40899543
54RPS6KC10.40899543
55MAPK10.40880117
56LATS10.39333893
57ARAF0.39022413
58MAP3K10.37668364
59STK390.37511661
60RPS6KA60.36710228
61MAPK80.36634032
62CAMK40.36466442
63CHEK10.34934374
64SGK2230.34130549
65SGK4940.34130549
66MARK10.30525994
67PRKCZ0.29941176
68MARK20.29366101
69RIPK40.28774926
70BMPR1B0.28557955
71MET0.27391511
72MAPK110.27389068
73PRKCG0.27073859
74SGK10.26304656
75MAPK100.26030535
76BLK0.25876264
77MAPK140.25309965
78NTRK30.24815484
79BRSK10.23823750
80PRKCB0.20472368
81TIE10.19314856
82AKT10.18031805
83ICK0.16139768
84MAP3K40.15131445
85DYRK30.13151917
86PRKAA10.11718818
87CHUK0.10175402
88MAP3K70.09360199
89PKN10.08822040
90MAP3K130.08390936
91FER0.08175326
92IKBKB0.07925933
93MAPK90.07516693
94PRKACB0.06590419
95PRKACA0.04745682
96RPS6KA30.03909249
97OXSR10.03779308
98JAK30.01916354
99NEK20.01536483
100MAP2K10.00881086

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.16750386
2Fatty acid biosynthesis_Homo sapiens_hsa000615.98080953
3Olfactory transduction_Homo sapiens_hsa047403.60576321
4Butanoate metabolism_Homo sapiens_hsa006502.63885436
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.02156088
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00078122
7Allograft rejection_Homo sapiens_hsa053301.94442914
8Type I diabetes mellitus_Homo sapiens_hsa049401.91916267
9Autoimmune thyroid disease_Homo sapiens_hsa053201.88146914
10Graft-versus-host disease_Homo sapiens_hsa053321.77468238
11Dorso-ventral axis formation_Homo sapiens_hsa043201.76605438
12Antigen processing and presentation_Homo sapiens_hsa046121.74306097
13Taste transduction_Homo sapiens_hsa047421.72864861
14Type II diabetes mellitus_Homo sapiens_hsa049301.64985745
15Phenylalanine metabolism_Homo sapiens_hsa003601.59421001
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53395934
17RNA transport_Homo sapiens_hsa030131.50932552
18Fatty acid degradation_Homo sapiens_hsa000711.47553190
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.44685820
20Viral myocarditis_Homo sapiens_hsa054161.41444047
21Fatty acid metabolism_Homo sapiens_hsa012121.39305270
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32025036
23Arginine and proline metabolism_Homo sapiens_hsa003301.29250912
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24868883
25Endocytosis_Homo sapiens_hsa041441.19330817
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19095033
27Adipocytokine signaling pathway_Homo sapiens_hsa049201.16391895
28Inositol phosphate metabolism_Homo sapiens_hsa005620.98834840
29Protein digestion and absorption_Homo sapiens_hsa049740.98341180
30Salivary secretion_Homo sapiens_hsa049700.95210842
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92913539
32Influenza A_Homo sapiens_hsa051640.91759971
33Arginine biosynthesis_Homo sapiens_hsa002200.91465142
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87087817
35Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86704001
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85526779
37Phototransduction_Homo sapiens_hsa047440.83932045
38Oocyte meiosis_Homo sapiens_hsa041140.80273364
39PPAR signaling pathway_Homo sapiens_hsa033200.80077968
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78712260
41cAMP signaling pathway_Homo sapiens_hsa040240.78229402
42Calcium signaling pathway_Homo sapiens_hsa040200.75684689
43Estrogen signaling pathway_Homo sapiens_hsa049150.74766490
44Cardiac muscle contraction_Homo sapiens_hsa042600.71576381
45Morphine addiction_Homo sapiens_hsa050320.71318086
46Fat digestion and absorption_Homo sapiens_hsa049750.71201532
47ABC transporters_Homo sapiens_hsa020100.70067394
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70055210
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68680144
50Renin-angiotensin system_Homo sapiens_hsa046140.67034182
51Hedgehog signaling pathway_Homo sapiens_hsa043400.64822746
52Tyrosine metabolism_Homo sapiens_hsa003500.62228347
53Acute myeloid leukemia_Homo sapiens_hsa052210.62159594
54Synaptic vesicle cycle_Homo sapiens_hsa047210.61361261
55VEGF signaling pathway_Homo sapiens_hsa043700.59343095
56Glycerolipid metabolism_Homo sapiens_hsa005610.56988194
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56454659
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55792833
59Nicotine addiction_Homo sapiens_hsa050330.55763841
60Circadian entrainment_Homo sapiens_hsa047130.54375653
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53022328
62Retinol metabolism_Homo sapiens_hsa008300.51807555
63mRNA surveillance pathway_Homo sapiens_hsa030150.50621477
64MAPK signaling pathway_Homo sapiens_hsa040100.49734985
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.47900393
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.47806179
67Bile secretion_Homo sapiens_hsa049760.47414811
68Selenocompound metabolism_Homo sapiens_hsa004500.44915221
69Glutamatergic synapse_Homo sapiens_hsa047240.44094974
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42818350
71Purine metabolism_Homo sapiens_hsa002300.40788124
72Gastric acid secretion_Homo sapiens_hsa049710.40346208
73Insulin secretion_Homo sapiens_hsa049110.39761499
74Renin secretion_Homo sapiens_hsa049240.39301043
75Viral carcinogenesis_Homo sapiens_hsa052030.37759858
76Tight junction_Homo sapiens_hsa045300.37317276
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.36997223
78Basal transcription factors_Homo sapiens_hsa030220.35634178
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.32919184
80Herpes simplex infection_Homo sapiens_hsa051680.31755559
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31722886
82Cholinergic synapse_Homo sapiens_hsa047250.30542149
83Biosynthesis of amino acids_Homo sapiens_hsa012300.29818718
84Prolactin signaling pathway_Homo sapiens_hsa049170.27174388
85Serotonergic synapse_Homo sapiens_hsa047260.26493040
86Pancreatic secretion_Homo sapiens_hsa049720.25800310
87Long-term potentiation_Homo sapiens_hsa047200.25510589
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22127739
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22069318
90Epstein-Barr virus infection_Homo sapiens_hsa051690.20754195
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19618909
92Oxytocin signaling pathway_Homo sapiens_hsa049210.18395660
93B cell receptor signaling pathway_Homo sapiens_hsa046620.18159593
94Toxoplasmosis_Homo sapiens_hsa051450.17958148
95Vitamin B6 metabolism_Homo sapiens_hsa007500.17170456
96Legionellosis_Homo sapiens_hsa051340.16932542
97Fanconi anemia pathway_Homo sapiens_hsa034600.15905482
98ECM-receptor interaction_Homo sapiens_hsa045120.14992254
99GABAergic synapse_Homo sapiens_hsa047270.14607663
100Adherens junction_Homo sapiens_hsa045200.13996558

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