SRSF10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.72168046
2DNA strand elongation involved in DNA replication (GO:0006271)4.51516119
3kinetochore organization (GO:0051383)4.40383970
4nuclear pore organization (GO:0006999)4.37699418
5DNA strand elongation (GO:0022616)4.34307108
6telomere maintenance via semi-conservative replication (GO:0032201)4.29334096
7DNA replication initiation (GO:0006270)4.26636403
8CENP-A containing nucleosome assembly (GO:0034080)4.24811632
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.23557584
10chromatin remodeling at centromere (GO:0031055)4.22541954
11nuclear pore complex assembly (GO:0051292)4.15468336
12DNA ligation (GO:0006266)4.10391807
13regulation of centriole replication (GO:0046599)4.05455026
14protein localization to kinetochore (GO:0034501)4.03366997
15mitotic recombination (GO:0006312)4.02460522
16meiotic chromosome segregation (GO:0045132)4.01794971
17telomere maintenance via recombination (GO:0000722)4.01322820
18DNA replication-independent nucleosome organization (GO:0034724)4.00680320
19DNA replication-independent nucleosome assembly (GO:0006336)4.00680320
20mitotic metaphase plate congression (GO:0007080)3.93576993
21mitotic sister chromatid cohesion (GO:0007064)3.91410759
22replication fork processing (GO:0031297)3.89285670
23double-strand break repair via nonhomologous end joining (GO:0006303)3.88127671
24non-recombinational repair (GO:0000726)3.88127671
25mitotic nuclear envelope disassembly (GO:0007077)3.78271769
26attachment of spindle microtubules to kinetochore (GO:0008608)3.76924095
27mitotic chromosome condensation (GO:0007076)3.76528144
28establishment of integrated proviral latency (GO:0075713)3.75676662
29kinetochore assembly (GO:0051382)3.74767088
30DNA replication checkpoint (GO:0000076)3.73864947
31metaphase plate congression (GO:0051310)3.66342920
32DNA replication-dependent nucleosome assembly (GO:0006335)3.65823414
33DNA replication-dependent nucleosome organization (GO:0034723)3.65823414
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61946021
35regulation of mitotic spindle checkpoint (GO:1903504)3.61946021
36DNA topological change (GO:0006265)3.61025866
37telomere maintenance via telomere lengthening (GO:0010833)3.60125257
38histone exchange (GO:0043486)3.59257804
39IMP biosynthetic process (GO:0006188)3.58047624
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.57720076
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.57571194
42nucleobase biosynthetic process (GO:0046112)3.51839504
43nuclear envelope disassembly (GO:0051081)3.49509024
44membrane disassembly (GO:0030397)3.49509024
45protein localization to chromosome, centromeric region (GO:0071459)3.49229228
46DNA catabolic process, exonucleolytic (GO:0000738)3.40522336
47negative regulation of DNA recombination (GO:0045910)3.37141450
48purine nucleobase biosynthetic process (GO:0009113)3.36228233
49ribosomal small subunit assembly (GO:0000028)3.35205212
50DNA duplex unwinding (GO:0032508)3.31401688
51DNA geometric change (GO:0032392)3.30734058
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.30479622
53somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.30479622
54isotype switching (GO:0045190)3.30479622
55pore complex assembly (GO:0046931)3.27325489
56mitotic G2/M transition checkpoint (GO:0044818)3.26944147
57establishment of chromosome localization (GO:0051303)3.24964883
58sister chromatid segregation (GO:0000819)3.24841473
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.23231957
60ATP-dependent chromatin remodeling (GO:0043044)3.22710468
61* negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19779976
62translesion synthesis (GO:0019985)3.19567801
63somatic cell DNA recombination (GO:0016444)3.17786647
64somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.17786647
65mitotic sister chromatid segregation (GO:0000070)3.16773280
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16520978
67viral mRNA export from host cell nucleus (GO:0046784)3.15252430
68chromatin assembly or disassembly (GO:0006333)3.15230182
69synapsis (GO:0007129)3.14778045
70somatic recombination of immunoglobulin gene segments (GO:0016447)3.14040017
71spindle assembly checkpoint (GO:0071173)3.12872133
72centriole replication (GO:0007099)3.12789459
73* negative regulation of mRNA processing (GO:0050686)3.11672045
74postreplication repair (GO:0006301)3.11383199
75telomere maintenance (GO:0000723)3.11256385
76proteasome assembly (GO:0043248)3.11086765
77spindle checkpoint (GO:0031577)3.10812762
78* negative regulation of RNA splicing (GO:0033119)3.10547331
79recombinational repair (GO:0000725)3.10389879
80negative regulation of mitotic sister chromatid separation (GO:2000816)3.10131707
81negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10131707
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10131707
83negative regulation of sister chromatid segregation (GO:0033046)3.10131707
84double-strand break repair via homologous recombination (GO:0000724)3.09661282
85telomere organization (GO:0032200)3.09352772
86negative regulation of chromosome segregation (GO:0051985)3.08879965
87dosage compensation (GO:0007549)3.07868958
88positive regulation of chromosome segregation (GO:0051984)3.07347116
89IMP metabolic process (GO:0046040)3.06967505
90mismatch repair (GO:0006298)3.06686876
91regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05298015
92mitotic spindle assembly checkpoint (GO:0007094)3.05238950
93regulation of centrosome duplication (GO:0010824)3.05233226
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04891048
95sister chromatid cohesion (GO:0007062)3.04512965
96regulation of spindle organization (GO:0090224)3.04189106
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.02249705
98* RNA splicing, via transesterification reactions (GO:0000375)3.02148334
99* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.01564398
100* mRNA splicing, via spliceosome (GO:0000398)3.01564398
101negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99675117
102maturation of SSU-rRNA (GO:0030490)2.98489094
103histone H2A acetylation (GO:0043968)2.98062321
104regulation of histone H3-K9 methylation (GO:0051570)2.98014169
105regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97327779
106regulation of DNA endoreduplication (GO:0032875)2.97316707
107termination of RNA polymerase II transcription (GO:0006369)2.96467154
108regulation of helicase activity (GO:0051095)2.96161532
109mitotic spindle checkpoint (GO:0071174)2.95843399
110maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.95545729
111regulation of chromosome segregation (GO:0051983)2.95148816
112DNA conformation change (GO:0071103)2.94867162
113somatic hypermutation of immunoglobulin genes (GO:0016446)2.94470526
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94470526
115regulation of mitotic sister chromatid separation (GO:0010965)2.94230544
116regulation of mitotic sister chromatid segregation (GO:0033047)2.94230544
117regulation of sister chromatid segregation (GO:0033045)2.94230544
118regulation of centrosome cycle (GO:0046605)2.92443936
119chromosome segregation (GO:0007059)2.90205342
120formation of translation preinitiation complex (GO:0001731)2.90107992
121DNA double-strand break processing (GO:0000729)2.89518148
122* RNA export from nucleus (GO:0006405)2.89437674
123ribosome assembly (GO:0042255)2.89298339
124regulation of sister chromatid cohesion (GO:0007063)2.88937752
125* mRNA export from nucleus (GO:0006406)2.88091299
126ribosome biogenesis (GO:0042254)2.87306471
127intra-S DNA damage checkpoint (GO:0031573)2.84755994
128transcription-coupled nucleotide-excision repair (GO:0006283)2.84227877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.53498204
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.46924770
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.12288451
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54820436
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97867267
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81657151
7MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74888974
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69239164
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.65236686
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.55791294
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.51778595
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.48162641
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48101979
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42152935
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41010480
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37215331
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.36684751
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.36037553
19AR_21909140_ChIP-Seq_LNCAP_Human2.29002022
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26223783
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22917771
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.18606904
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18492475
24VDR_23849224_ChIP-Seq_CD4+_Human2.17852208
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15569787
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.15197819
27XRN2_22483619_ChIP-Seq_HELA_Human2.13292675
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12339014
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07143959
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.02931402
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02339875
32ELK1_19687146_ChIP-ChIP_HELA_Human2.00230279
33E2F7_22180533_ChIP-Seq_HELA_Human10.5978884
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.97730408
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93884525
36FOXP3_21729870_ChIP-Seq_TREG_Human1.90054761
37FUS_26573619_Chip-Seq_HEK293_Human1.89139389
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83559121
39ZNF274_21170338_ChIP-Seq_K562_Hela1.83248603
40TTF2_22483619_ChIP-Seq_HELA_Human1.80428690
41CIITA_25753668_ChIP-Seq_RAJI_Human1.78754201
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75705929
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.75310093
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73667623
45* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72517531
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71747357
47DCP1A_22483619_ChIP-Seq_HELA_Human1.70262898
48MYC_22102868_ChIP-Seq_BL_Human1.64977371
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63962679
50GABP_19822575_ChIP-Seq_HepG2_Human1.63282061
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61866500
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60972974
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59429433
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59351348
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58243366
56IGF1R_20145208_ChIP-Seq_DFB_Human1.56442785
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53350244
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48102971
59KDM5A_27292631_Chip-Seq_BREAST_Human1.43133371
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.42876685
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39630317
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35673719
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34055685
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33662312
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31435125
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31236448
67VDR_22108803_ChIP-Seq_LS180_Human1.30469071
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30320932
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19040749
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18734320
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.16761356
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.13295517
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12871181
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12805092
75IRF1_19129219_ChIP-ChIP_H3396_Human1.11667617
76TFEB_21752829_ChIP-Seq_HELA_Human1.11471119
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10710008
78TAF15_26573619_Chip-Seq_HEK293_Human1.10193225
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09433687
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07680720
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.06877993
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06720304
83MYC_18940864_ChIP-ChIP_HL60_Human1.05310804
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04827363
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04060841
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02583254
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01132627
88CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01004793
89PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00352508
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98486304
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97545113
92P300_19829295_ChIP-Seq_ESCs_Human0.96276171
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96165167
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93040868
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92578681
96KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91742003
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91026208
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88531769
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.86204731
100EWS_26573619_Chip-Seq_HEK293_Human0.86013565
101* SPI1_23547873_ChIP-Seq_NB4_Human0.84666404
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83692940
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82644593
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82069927
105POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82046062
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81289677
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79759515
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78466744
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.77011296
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75162446
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.75004128
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73949926
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73360451
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73178219
115CHD1_26751641_Chip-Seq_LNCaP_Human0.72338111
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.70946125
117VDR_21846776_ChIP-Seq_THP-1_Human0.70903695
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.70505542
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.68695680
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.68503671
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.67149069
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.67025278
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.66724432
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.66721773
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.66484672
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.65750776
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.65466086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.49418277
2MP0003693_abnormal_embryo_hatching4.10651842
3MP0008057_abnormal_DNA_replication4.08861955
4MP0003111_abnormal_nucleus_morphology3.73871130
5MP0004957_abnormal_blastocyst_morpholog3.59806199
6MP0003077_abnormal_cell_cycle3.53153419
7MP0008058_abnormal_DNA_repair3.31694606
8MP0008007_abnormal_cellular_replicative2.98389068
9MP0003123_paternal_imprinting2.81521820
10MP0008877_abnormal_DNA_methylation2.64717970
11MP0002396_abnormal_hematopoietic_system2.54391556
12MP0003121_genomic_imprinting2.28711305
13MP0008932_abnormal_embryonic_tissue2.20710198
14MP0000350_abnormal_cell_proliferation1.98531724
15MP0003786_premature_aging1.97379467
16MP0004808_abnormal_hematopoietic_stem1.90501928
17MP0006054_spinal_hemorrhage1.87133522
18MP0001730_embryonic_growth_arrest1.84162431
19MP0010352_gastrointestinal_tract_polyps1.79616399
20MP0003718_maternal_effect1.79583607
21MP0006072_abnormal_retinal_apoptosis1.74034608
22MP0010307_abnormal_tumor_latency1.65459876
23MP0010030_abnormal_orbit_morphology1.64206353
24MP0003567_abnormal_fetal_cardiomyocyte1.62052678
25MP0000490_abnormal_crypts_of1.60271218
26MP0005380_embryogenesis_phenotype1.57012367
27MP0001672_abnormal_embryogenesis/_devel1.57012367
28MP0003890_abnormal_embryonic-extraembry1.55601302
29MP0001697_abnormal_embryo_size1.53539228
30MP0003787_abnormal_imprinting1.51720518
31MP0001188_hyperpigmentation1.49804214
32MP0003984_embryonic_growth_retardation1.45130172
33MP0002085_abnormal_embryonic_tissue1.44758691
34MP0000537_abnormal_urethra_morphology1.42502654
35MP0002088_abnormal_embryonic_growth/wei1.40584494
36MP0002102_abnormal_ear_morphology1.40472752
37MP0002084_abnormal_developmental_patter1.38397056
38* MP0004197_abnormal_fetal_growth/weight/1.38139409
39MP0002938_white_spotting1.36497844
40MP0006292_abnormal_olfactory_placode1.30622214
41MP0001293_anophthalmia1.30451526
42* MP0002080_prenatal_lethality1.29821204
43MP0002210_abnormal_sex_determination1.28917259
44MP0002086_abnormal_extraembryonic_tissu1.28366201
45MP0009053_abnormal_anal_canal1.28133000
46MP0000566_synostosis1.26348719
47MP0000313_abnormal_cell_death1.25582764
48MP0003941_abnormal_skin_development1.21877247
49MP0006035_abnormal_mitochondrial_morpho1.18382735
50MP0003763_abnormal_thymus_physiology1.17881771
51MP0002019_abnormal_tumor_incidence1.16136395
52MP0001545_abnormal_hematopoietic_system1.14425924
53MP0005397_hematopoietic_system_phenotyp1.14425924
54MP0005076_abnormal_cell_differentiation1.13847084
55MP0000372_irregular_coat_pigmentation1.10598098
56MP0002009_preneoplasia1.09516339
57MP0001145_abnormal_male_reproductive1.08445042
58MP0000703_abnormal_thymus_morphology1.06282222
59MP0001529_abnormal_vocalization1.03842327
60MP0003315_abnormal_perineum_morphology1.03781820
61MP0003937_abnormal_limbs/digits/tail_de1.02815281
62MP0002751_abnormal_autonomic_nervous1.01602149
63MP0008789_abnormal_olfactory_epithelium1.00967917
64MP0005075_abnormal_melanosome_morpholog0.99918395
65MP0002160_abnormal_reproductive_system0.99666249
66MP0004147_increased_porphyrin_level0.98855030
67MP0001119_abnormal_female_reproductive0.98815286
68MP0002398_abnormal_bone_marrow0.97818949
69MP0000653_abnormal_sex_gland0.95179385
70MP0001177_atelectasis0.94159939
71MP0001286_abnormal_eye_development0.94079897
72MP0003943_abnormal_hepatobiliary_system0.93752529
73MP0008995_early_reproductive_senescence0.92259294
74MP0002233_abnormal_nose_morphology0.92184489
75MP0005253_abnormal_eye_physiology0.91924873
76MP0001929_abnormal_gametogenesis0.91406694
77MP0000049_abnormal_middle_ear0.89648607
78MP0003122_maternal_imprinting0.88413950
79MP0000631_abnormal_neuroendocrine_gland0.88044647
80MP0001915_intracranial_hemorrhage0.87238912
81MP0003119_abnormal_digestive_system0.85160561
82MP0000428_abnormal_craniofacial_morphol0.83914604
83MP0002095_abnormal_skin_pigmentation0.83444338
84MP0002111_abnormal_tail_morphology0.82710747
85MP0005389_reproductive_system_phenotype0.82414838
86MP0002722_abnormal_immune_system0.81753912
87MP0005187_abnormal_penis_morphology0.81097464
88MP0003136_yellow_coat_color0.80999030
89MP0003115_abnormal_respiratory_system0.80971635
90MP0003221_abnormal_cardiomyocyte_apopto0.80361866
91MP0003935_abnormal_craniofacial_develop0.80256328
92MP0000689_abnormal_spleen_morphology0.79370650
93MP0005394_taste/olfaction_phenotype0.78988849
94MP0005499_abnormal_olfactory_system0.78988849
95MP0004133_heterotaxia0.78397325
96MP0003698_abnormal_male_reproductive0.77662694
97MP0003942_abnormal_urinary_system0.77414372
98MP0002282_abnormal_trachea_morphology0.77282755
99MP0009703_decreased_birth_body0.76602008
100MP0005391_vision/eye_phenotype0.76474042
101MP0000432_abnormal_head_morphology0.76403360
102MP0009697_abnormal_copulation0.75902865
103MP0003755_abnormal_palate_morphology0.74768459
104MP0009672_abnormal_birth_weight0.74692944
105MP0009333_abnormal_splenocyte_physiolog0.74485032
106MP0002932_abnormal_joint_morphology0.74325021
107MP0002006_tumorigenesis0.72610486
108MP0002114_abnormal_axial_skeleton0.72449072
109MP0006036_abnormal_mitochondrial_physio0.72234680
110MP0000647_abnormal_sebaceous_gland0.71684114
111MP0000358_abnormal_cell_content/0.71452649
112MP0002092_abnormal_eye_morphology0.71301293
113MP0000516_abnormal_urinary_system0.71265148
114MP0005367_renal/urinary_system_phenotyp0.71265148
115MP0002166_altered_tumor_susceptibility0.70764788
116MP0005220_abnormal_exocrine_pancreas0.70561043
117MP0003861_abnormal_nervous_system0.70492511
118MP0002249_abnormal_larynx_morphology0.67959401
119MP0002429_abnormal_blood_cell0.66439703
120MP0002132_abnormal_respiratory_system0.66015496
121MP0002163_abnormal_gland_morphology0.65292472
122MP0002697_abnormal_eye_size0.64929423
123MP0000015_abnormal_ear_pigmentation0.64787991
124MP0003385_abnormal_body_wall0.64358819
125MP0005174_abnormal_tail_pigmentation0.64297737
126MP0002116_abnormal_craniofacial_bone0.64228558
127MP0002234_abnormal_pharynx_morphology0.64052794
128MP0002109_abnormal_limb_morphology0.63772049
129MP0002925_abnormal_cardiovascular_devel0.63049248
130MP0003195_calcinosis0.62463301
131MP0005645_abnormal_hypothalamus_physiol0.57696140
132MP0000383_abnormal_hair_follicle0.56020005
133MP0002090_abnormal_vision0.55609619
134MP0003806_abnormal_nucleotide_metabolis0.54786257

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.09136317
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89774752
3Birth length less than 3rd percentile (HP:0003561)3.84600715
4Colon cancer (HP:0003003)3.27165144
511 pairs of ribs (HP:0000878)3.14654460
6Abnormality of chromosome stability (HP:0003220)3.13467415
7Patellar aplasia (HP:0006443)3.06724544
8Meckel diverticulum (HP:0002245)3.06431454
9Medulloblastoma (HP:0002885)3.02599849
10Reticulocytopenia (HP:0001896)2.98459671
11Abnormal number of erythroid precursors (HP:0012131)2.97700297
12Abnormality of the ileum (HP:0001549)2.95706764
13Volvulus (HP:0002580)2.91809564
14Aplasia/Hypoplasia of the patella (HP:0006498)2.86640603
15Abnormality of cells of the erythroid lineage (HP:0012130)2.82110005
16Selective tooth agenesis (HP:0001592)2.80952632
17Ectopic kidney (HP:0000086)2.79580281
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.77641377
19Short 4th metacarpal (HP:0010044)2.76269321
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.76269321
21Abnormality of the preputium (HP:0100587)2.75600671
22Myelodysplasia (HP:0002863)2.64848103
23Abnormal lung lobation (HP:0002101)2.64761173
24Duodenal stenosis (HP:0100867)2.58412025
25Small intestinal stenosis (HP:0012848)2.58412025
26Aplastic anemia (HP:0001915)2.58411266
27Nephroblastoma (Wilms tumor) (HP:0002667)2.49439469
28Supernumerary spleens (HP:0009799)2.43979601
29Abnormal number of incisors (HP:0011064)2.42783213
30Abnormality of the anterior horn cell (HP:0006802)2.37177175
31Degeneration of anterior horn cells (HP:0002398)2.37177175
32Increased nuchal translucency (HP:0010880)2.36851138
33Embryonal renal neoplasm (HP:0011794)2.35222218
34Oral leukoplakia (HP:0002745)2.28810500
35Breast hypoplasia (HP:0003187)2.25910571
36Short middle phalanx of the 5th finger (HP:0004220)2.19788876
37Abnormality of the fingertips (HP:0001211)2.17699763
38Absent thumb (HP:0009777)2.16206775
39Sloping forehead (HP:0000340)2.15582673
40Abnormality of the duodenum (HP:0002246)2.15326340
41Pancreatic islet-cell hyperplasia (HP:0004510)2.15324978
42Missing ribs (HP:0000921)2.14297788
43Abnormality of the carotid arteries (HP:0005344)2.12982065
44Deviation of the thumb (HP:0009603)2.06094583
45Abnormality of methionine metabolism (HP:0010901)2.05977426
46Long eyelashes (HP:0000527)2.05664323
47Ependymoma (HP:0002888)2.05494031
48Proximal placement of thumb (HP:0009623)2.05420012
49Neoplasm of the adrenal cortex (HP:0100641)2.05375948
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.03858894
51Combined immunodeficiency (HP:0005387)2.01883653
52Bone marrow hypocellularity (HP:0005528)2.00697510
53Optic nerve coloboma (HP:0000588)2.00692913
54Cortical dysplasia (HP:0002539)2.00302723
55Agnosia (HP:0010524)1.99406042
56Clubbing of toes (HP:0100760)1.97004038
57Rhabdomyosarcoma (HP:0002859)1.96641914
58Atresia of the external auditory canal (HP:0000413)1.95108308
59Deep philtrum (HP:0002002)1.93443117
60Embryonal neoplasm (HP:0002898)1.93220176
61Astrocytoma (HP:0009592)1.92772791
62Abnormality of the astrocytes (HP:0100707)1.92772791
63Neoplasm of the pancreas (HP:0002894)1.92519540
64Absent radius (HP:0003974)1.92503649
65Acute lymphatic leukemia (HP:0006721)1.92253444
66Premature graying of hair (HP:0002216)1.91845679
67Abnormality of DNA repair (HP:0003254)1.90441488
68Oligodactyly (hands) (HP:0001180)1.90071817
69Pancreatic cysts (HP:0001737)1.88845855
70Impulsivity (HP:0100710)1.88532723
71Short thumb (HP:0009778)1.87367229
72Carpal bone hypoplasia (HP:0001498)1.87281436
73Severe combined immunodeficiency (HP:0004430)1.86865164
74Abnormality of the labia minora (HP:0012880)1.85756524
75Renal duplication (HP:0000075)1.85545025
76Acute myeloid leukemia (HP:0004808)1.85370005
77Facial hemangioma (HP:0000329)1.84159914
78Tracheoesophageal fistula (HP:0002575)1.83700124
79Abnormality of the 4th metacarpal (HP:0010012)1.83649882
80Abnormality of the heme biosynthetic pathway (HP:0010472)1.83037599
81Aplasia involving forearm bones (HP:0009822)1.82320127
82Absent forearm bone (HP:0003953)1.82320127
83Shawl scrotum (HP:0000049)1.81322023
84Rib fusion (HP:0000902)1.81286838
85Broad palm (HP:0001169)1.80088154
86Neoplasm of the adrenal gland (HP:0100631)1.79121042
87Gonadotropin excess (HP:0000837)1.78521458
88Duplicated collecting system (HP:0000081)1.78040190
89Arteriovenous malformation (HP:0100026)1.77764994
90B lymphocytopenia (HP:0010976)1.77713272
91Cellular immunodeficiency (HP:0005374)1.75983261
92Syringomyelia (HP:0003396)1.75886911
93Spinal cord lesions (HP:0100561)1.75886911
94Neoplasm of the small intestine (HP:0100833)1.75081249
95Neoplasm of the oral cavity (HP:0100649)1.74900785
96Biliary tract neoplasm (HP:0100574)1.74893172
97Cafe-au-lait spot (HP:0000957)1.74728130
98Pallor (HP:0000980)1.74592415
99Breast carcinoma (HP:0003002)1.74542771
100Basal cell carcinoma (HP:0002671)1.73926055
101Abnormality of the renal collecting system (HP:0004742)1.73610853
102Amaurosis fugax (HP:0100576)1.71666707
103Overlapping toe (HP:0001845)1.70690891
104Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70429832
105Dandy-Walker malformation (HP:0001305)1.70228852
106Lymphoma (HP:0002665)1.69891299
107Choanal atresia (HP:0000453)1.69704265
108Multiple enchondromatosis (HP:0005701)1.69631586
109Aqueductal stenosis (HP:0002410)1.69210571
110Preaxial hand polydactyly (HP:0001177)1.68288619
111Abnormal spermatogenesis (HP:0008669)1.68273301
112Ovarian neoplasm (HP:0100615)1.66944664
113Megaloblastic anemia (HP:0001889)1.66905630
114Neoplasm of striated muscle (HP:0009728)1.66836149
115Cutaneous melanoma (HP:0012056)1.65995742
116Mesomelia (HP:0003027)1.65926428
117Neoplasm of the colon (HP:0100273)1.65770988
118Abnormality of the pons (HP:0007361)1.65532753
119Methylmalonic acidemia (HP:0002912)1.65246603
120Pancreatic fibrosis (HP:0100732)1.65102617
121Intestinal atresia (HP:0011100)1.64945386
122Triphalangeal thumb (HP:0001199)1.64359851
123Abnormal hair whorl (HP:0010721)1.64278578
124Abnormality of the incisor (HP:0000676)1.64165431
125Abnormality of the calcaneus (HP:0008364)1.63906680
126Increased hepatocellular lipid droplets (HP:0006565)1.63739859
127Abnormality of the metopic suture (HP:0005556)1.63034323
128Gastrointestinal atresia (HP:0002589)1.62708631
129Prominent metopic ridge (HP:0005487)1.62607119
130Microvesicular hepatic steatosis (HP:0001414)1.62068522
131Astigmatism (HP:0000483)1.61800289
132Rough bone trabeculation (HP:0100670)1.60863953
133Bifid tongue (HP:0010297)1.60235540
134Abnormality of chromosome segregation (HP:0002916)1.59957555
135True hermaphroditism (HP:0010459)1.59728532
136Long clavicles (HP:0000890)1.59649760
137Facial cleft (HP:0002006)1.59528010
138Abnormality of homocysteine metabolism (HP:0010919)1.58964987
139Homocystinuria (HP:0002156)1.58964987
140Small hand (HP:0200055)1.58953490
141Short 5th finger (HP:0009237)1.58331397
142Glioma (HP:0009733)1.57859434
143Abnormality of cochlea (HP:0000375)1.57482771
144Abnormality of serum amino acid levels (HP:0003112)1.57009584
145Horseshoe kidney (HP:0000085)1.56912917
146High pitched voice (HP:0001620)1.56706038
147Slender long bone (HP:0003100)1.56626377
148Stenosis of the external auditory canal (HP:0000402)1.55360503
149Hypoplasia of the pons (HP:0012110)1.54419434
150Abnormality of B cell number (HP:0010975)1.54372809
151Panhypogammaglobulinemia (HP:0003139)1.52475978
152Prominent nose (HP:0000448)1.51946804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.83714824
2WEE13.58621448
3SRPK13.41908232
4MKNK13.18780322
5BUB13.04856474
6EIF2AK13.01593066
7MKNK22.69686268
8ACVR1B2.47520049
9BRSK22.43848731
10NEK22.43462091
11TRIM282.40654492
12PASK2.31066368
13VRK12.13774667
14PLK42.10386883
15ATR2.10058442
16PBK1.97966279
17BRD41.94392486
18EIF2AK31.91991392
19PLK11.88535641
20TSSK61.83296178
21PLK31.82273843
22RPS6KA41.80786658
23DYRK31.80207234
24CDK121.77485065
25ERBB31.76371518
26BMPR1B1.75498358
27AURKB1.69304857
28TNIK1.69078899
29TTK1.68519872
30NEK11.67966648
31CDK71.63369923
32FRK1.61201889
33WNK31.58249978
34TGFBR11.55230133
35TAF11.51901783
36ZAK1.43664916
37VRK21.42503080
38CHEK21.39702097
39CCNB11.37160875
40CHEK11.31284658
41BRSK11.30258980
42RPS6KB21.28710074
43PNCK1.21824826
44MAP4K21.21775203
45ATM1.18515569
46YES11.18421053
47STK41.15759916
48CDK41.14864798
49CDK81.09930812
50SCYL21.02434418
51SIK31.00957158
52STK160.92965442
53MAP3K100.92021113
54EIF2AK20.91701108
55PAK40.91645729
56EEF2K0.91284839
57CDK60.90784771
58CDK20.89582767
59PLK20.89269447
60STK100.89073854
61NEK90.87500351
62PIM10.87394589
63MAP3K80.87239623
64TLK10.84607809
65NLK0.83065693
66TEC0.82405111
67STK30.81124114
68PDK20.79229350
69CLK10.77864369
70MAP3K40.77787092
71STK38L0.77464577
72CDK30.76659681
73CDK10.75951796
74AURKA0.74713085
75INSRR0.73775372
76CSNK1G10.69632590
77FLT30.66447929
78CSNK2A10.64255729
79CSNK2A20.61774005
80NME20.60910753
81BTK0.58194950
82CHUK0.56187012
83LATS10.55265457
84RPS6KA50.54328265
85PIM20.52803072
86MELK0.49805967
87IRAK40.49175916
88MAP4K10.48731867
89OXSR10.48187453
90RPS6KB10.47586992
91CSNK1G30.47073396
92CSNK1G20.46413858
93CASK0.46118339
94CSNK1E0.45259960
95TAOK20.44363586
96FGFR20.43744312
97CSNK1A1L0.43328457
98STK390.42193227
99NUAK10.42057172
100PRKDC0.41682438
101JAK30.41521109
102GRK10.40695754
103STK240.39169418
104MAPK140.38771250
105AKT10.38535359
106ERBB40.38277926
107AKT30.37245572
108CDK90.37082871
109FGFR10.36746967
110CAMK1G0.36474859
111NME10.36436062
112TXK0.35148486
113DYRK20.34291462
114BCR0.31736541
115MAPK130.31209118
116FGFR30.31112224
117RPS6KL10.30581440
118RPS6KC10.30581440
119RPS6KA60.29407607
120MST40.29309194
121KIT0.29093312
122MAP2K30.27499913
123EPHA20.27179327
124TESK20.26960325
125TRPM70.25835850
126CAMK1D0.24310543
127CSNK1D0.24082583
128ALK0.23921746
129MAP3K30.22607078
130MTOR0.22521885
131AKT20.22399625
132GSK3B0.22352056
133LRRK20.21360009

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.85895866
2Mismatch repair_Homo sapiens_hsa034304.24828887
3* Spliceosome_Homo sapiens_hsa030403.39874844
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36555667
5Base excision repair_Homo sapiens_hsa034103.26371535
6Homologous recombination_Homo sapiens_hsa034403.14100718
7Cell cycle_Homo sapiens_hsa041103.04353413
8RNA transport_Homo sapiens_hsa030132.95894859
9Nucleotide excision repair_Homo sapiens_hsa034202.85830418
10Fanconi anemia pathway_Homo sapiens_hsa034602.61498040
11RNA polymerase_Homo sapiens_hsa030202.59052794
12Non-homologous end-joining_Homo sapiens_hsa034502.44890462
13RNA degradation_Homo sapiens_hsa030182.26520068
14One carbon pool by folate_Homo sapiens_hsa006702.26151230
15Ribosome_Homo sapiens_hsa030102.22420345
16Basal transcription factors_Homo sapiens_hsa030222.18374503
17mRNA surveillance pathway_Homo sapiens_hsa030152.15757416
18Pyrimidine metabolism_Homo sapiens_hsa002402.14701258
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10566954
20Proteasome_Homo sapiens_hsa030502.07398664
21p53 signaling pathway_Homo sapiens_hsa041151.66985231
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53999197
23Propanoate metabolism_Homo sapiens_hsa006401.52236684
24Systemic lupus erythematosus_Homo sapiens_hsa053221.30098302
25Herpes simplex infection_Homo sapiens_hsa051681.29617839
26Epstein-Barr virus infection_Homo sapiens_hsa051691.23585977
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23335746
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22147886
29Purine metabolism_Homo sapiens_hsa002301.18540371
30Viral carcinogenesis_Homo sapiens_hsa052031.13966457
31Steroid biosynthesis_Homo sapiens_hsa001001.11200856
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06569126
33HTLV-I infection_Homo sapiens_hsa051661.05907974
34Antigen processing and presentation_Homo sapiens_hsa046121.05022528
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00009974
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99997613
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99585853
38MicroRNAs in cancer_Homo sapiens_hsa052060.97318979
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96989765
40Oocyte meiosis_Homo sapiens_hsa041140.96188145
41Fatty acid elongation_Homo sapiens_hsa000620.94774141
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93550630
43Small cell lung cancer_Homo sapiens_hsa052220.90037035
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87471100
45Thyroid cancer_Homo sapiens_hsa052160.82573060
46Pyruvate metabolism_Homo sapiens_hsa006200.81687922
47TGF-beta signaling pathway_Homo sapiens_hsa043500.78348453
48Colorectal cancer_Homo sapiens_hsa052100.77596540
49Basal cell carcinoma_Homo sapiens_hsa052170.76255400
50Primary immunodeficiency_Homo sapiens_hsa053400.76008782
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75332541
52Protein export_Homo sapiens_hsa030600.74604728
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73286249
54N-Glycan biosynthesis_Homo sapiens_hsa005100.72355062
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72110410
56Hepatitis B_Homo sapiens_hsa051610.68834064
57Legionellosis_Homo sapiens_hsa051340.68491761
58Measles_Homo sapiens_hsa051620.66066447
59Huntingtons disease_Homo sapiens_hsa050160.65881692
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65092566
61Chronic myeloid leukemia_Homo sapiens_hsa052200.64929606
62Notch signaling pathway_Homo sapiens_hsa043300.64626836
63Parkinsons disease_Homo sapiens_hsa050120.63471848
64Butanoate metabolism_Homo sapiens_hsa006500.63357329
65Hippo signaling pathway_Homo sapiens_hsa043900.62866011
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62531152
67Alcoholism_Homo sapiens_hsa050340.61612426
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.60649410
69Vitamin B6 metabolism_Homo sapiens_hsa007500.60420851
70Biosynthesis of amino acids_Homo sapiens_hsa012300.56247036
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55616155
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52607118
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52527885
74Adherens junction_Homo sapiens_hsa045200.51789189
75Viral myocarditis_Homo sapiens_hsa054160.50857251
76Apoptosis_Homo sapiens_hsa042100.49738987
77Prostate cancer_Homo sapiens_hsa052150.49736106
78Influenza A_Homo sapiens_hsa051640.49640045
79Selenocompound metabolism_Homo sapiens_hsa004500.49310085
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47954869
81Caffeine metabolism_Homo sapiens_hsa002320.46997936
82Pathways in cancer_Homo sapiens_hsa052000.46306887
83Oxidative phosphorylation_Homo sapiens_hsa001900.45806210
84Carbon metabolism_Homo sapiens_hsa012000.45798619
85Shigellosis_Homo sapiens_hsa051310.45628572
86Wnt signaling pathway_Homo sapiens_hsa043100.45473417
87Hematopoietic cell lineage_Homo sapiens_hsa046400.44650283
88Hedgehog signaling pathway_Homo sapiens_hsa043400.44111499
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42286512
90Phototransduction_Homo sapiens_hsa047440.41419349
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40678621
92Nitrogen metabolism_Homo sapiens_hsa009100.40425686
93Pancreatic cancer_Homo sapiens_hsa052120.39710021
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38146057
95Metabolic pathways_Homo sapiens_hsa011000.37800733
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37728067
97Glutathione metabolism_Homo sapiens_hsa004800.37566009
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36117613
99Circadian rhythm_Homo sapiens_hsa047100.34917741
100Folate biosynthesis_Homo sapiens_hsa007900.33739245
101Vitamin digestion and absorption_Homo sapiens_hsa049770.32548754
102Endometrial cancer_Homo sapiens_hsa052130.32392724
103Peroxisome_Homo sapiens_hsa041460.31875608
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31302529
105Non-small cell lung cancer_Homo sapiens_hsa052230.30625196
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30246747
107Lysine degradation_Homo sapiens_hsa003100.29937711
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.29557946
109Fatty acid metabolism_Homo sapiens_hsa012120.28770107
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28364177
111Acute myeloid leukemia_Homo sapiens_hsa052210.28176593
112FoxO signaling pathway_Homo sapiens_hsa040680.28006068
113Melanoma_Homo sapiens_hsa052180.27841639
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.27797778
115Bladder cancer_Homo sapiens_hsa052190.27155047
116B cell receptor signaling pathway_Homo sapiens_hsa046620.24541877
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23201322
118Leishmaniasis_Homo sapiens_hsa051400.22534991
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22208894
120T cell receptor signaling pathway_Homo sapiens_hsa046600.22195636
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21612655
122Proteoglycans in cancer_Homo sapiens_hsa052050.21244591
123HIF-1 signaling pathway_Homo sapiens_hsa040660.21213939
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20534469
125Pentose phosphate pathway_Homo sapiens_hsa000300.19719728
126Allograft rejection_Homo sapiens_hsa053300.18986928
127Toxoplasmosis_Homo sapiens_hsa051450.18834159
128mTOR signaling pathway_Homo sapiens_hsa041500.18375668
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.18206124
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.18027421
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.17349798
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.16961931
133Regulation of autophagy_Homo sapiens_hsa041400.16416238
134Ether lipid metabolism_Homo sapiens_hsa005650.15986183
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15816259
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.15787600
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14371143
138TNF signaling pathway_Homo sapiens_hsa046680.13906487
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.13467347
140Tryptophan metabolism_Homo sapiens_hsa003800.09975819
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09008244
142Alzheimers disease_Homo sapiens_hsa050100.07076344
143beta-Alanine metabolism_Homo sapiens_hsa004100.05624006
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05067319
145Retinol metabolism_Homo sapiens_hsa008300.02920496

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