SRSF10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)6.83072263
2seminiferous tubule development (GO:0072520)5.71581512
3replication fork processing (GO:0031297)5.18948825
4negative regulation of cytosolic calcium ion concentration (GO:0051481)5.14770450
5behavioral response to ethanol (GO:0048149)5.14496361
6regulation of female gonad development (GO:2000194)4.92271768
7establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.69696089
8mitochondrion transport along microtubule (GO:0047497)4.69696089
9pyrimidine dimer repair (GO:0006290)4.65282104
10behavioral response to nicotine (GO:0035095)4.56298010
11establishment of mitochondrion localization (GO:0051654)4.36444618
12cornea development in camera-type eye (GO:0061303)4.28961366
13protein import into peroxisome matrix (GO:0016558)4.25960727
14piRNA metabolic process (GO:0034587)4.21109011
15maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.20616093
16negative regulation of mast cell activation (GO:0033004)4.10246283
17centrosome duplication (GO:0051298)4.06583877
18phosphorelay signal transduction system (GO:0000160)3.78457409
19regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.70031091
20regulation of fatty acid beta-oxidation (GO:0031998)3.65145178
21regulation of nuclear cell cycle DNA replication (GO:0033262)3.63088011
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.60984210
23centriole replication (GO:0007099)3.52815494
24DNA replication-dependent nucleosome assembly (GO:0006335)3.51288564
25DNA replication-dependent nucleosome organization (GO:0034723)3.51288564
26regulation of non-canonical Wnt signaling pathway (GO:2000050)3.50352010
27positive regulation of fatty acid transport (GO:2000193)3.48737908
28opioid receptor signaling pathway (GO:0038003)3.47324499
29DNA integration (GO:0015074)3.45126235
30neural tube formation (GO:0001841)3.41663301
31cell migration in hindbrain (GO:0021535)3.40621962
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.39943885
33positive regulation of immune response to tumor cell (GO:0002839)3.39202268
34regulation of immune response to tumor cell (GO:0002837)3.39202268
35regulation of response to tumor cell (GO:0002834)3.39202268
36positive regulation of response to tumor cell (GO:0002836)3.39202268
37positive regulation of icosanoid secretion (GO:0032305)3.36817454
38regulation of action potential (GO:0098900)3.33938476
39regulation of chromatin silencing (GO:0031935)3.32030227
40misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.30186845
41photoreceptor cell maintenance (GO:0045494)3.29087560
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.27488285
43DNA double-strand break processing (GO:0000729)3.25485283
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.25142796
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25142796
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25142796
47glial cell proliferation (GO:0014009)3.23753616
48GMP metabolic process (GO:0046037)3.22381423
49centrosome localization (GO:0051642)3.18668394
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18343795
51neuronal action potential (GO:0019228)3.17356672
52regulation of fever generation (GO:0031620)3.16165278
53tryptophan catabolic process (GO:0006569)3.15304919
54indole-containing compound catabolic process (GO:0042436)3.15304919
55indolalkylamine catabolic process (GO:0046218)3.15304919
56fucose catabolic process (GO:0019317)3.13891555
57L-fucose metabolic process (GO:0042354)3.13891555
58L-fucose catabolic process (GO:0042355)3.13891555
59regulation of heat generation (GO:0031650)3.13093096
60primary amino compound metabolic process (GO:1901160)3.11124536
61regulation of smooth muscle cell apoptotic process (GO:0034391)3.08614783
62regulation of acrosome reaction (GO:0060046)3.08257815
63serotonin metabolic process (GO:0042428)3.07434860
64regulation of hippo signaling (GO:0035330)3.06106387
65regulation of penile erection (GO:0060405)3.05337802
66positive regulation of heat generation (GO:0031652)3.05097784
67purine-containing compound salvage (GO:0043101)2.99283620
68negative regulation of fatty acid metabolic process (GO:0045922)2.97736044
69nucleoside salvage (GO:0043174)2.97309981
70histone H3-K36 demethylation (GO:0070544)2.86207447
71negative regulation of neurological system process (GO:0031645)2.85997854
72mitochondrial DNA replication (GO:0006264)2.84010234
73negative regulation of nitric-oxide synthase activity (GO:0051001)2.81397525
74regulation of fatty acid oxidation (GO:0046320)2.81299965
75indolalkylamine metabolic process (GO:0006586)2.80917220
76regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.79985260
77positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.79985260
78detection of light stimulus involved in visual perception (GO:0050908)2.79167728
79detection of light stimulus involved in sensory perception (GO:0050962)2.79167728
80indole-containing compound metabolic process (GO:0042430)2.78667952
81glucocorticoid receptor signaling pathway (GO:0042921)2.77615772
82DNA-dependent DNA replication (GO:0006261)2.76283515
83reflex (GO:0060004)2.76038481
84positive regulation of cell size (GO:0045793)2.75682412
85detection of mechanical stimulus involved in sensory perception (GO:0050974)2.74346197
86regulation of feeding behavior (GO:0060259)2.72721081
87adult feeding behavior (GO:0008343)2.72220442
88positive regulation of organic acid transport (GO:0032892)2.71987477
89histone H4-K12 acetylation (GO:0043983)2.69305585
90nucleotide transmembrane transport (GO:1901679)2.69007707
91pharyngeal system development (GO:0060037)2.68492424
92regulation of telomere maintenance (GO:0032204)2.67440320
93double-strand break repair via homologous recombination (GO:0000724)2.67334317
94replicative senescence (GO:0090399)2.65024316
95regulation of catecholamine metabolic process (GO:0042069)2.64573518
96regulation of dopamine metabolic process (GO:0042053)2.64573518
97flavonoid metabolic process (GO:0009812)2.63938407
98lens morphogenesis in camera-type eye (GO:0002089)2.63719965
99recombinational repair (GO:0000725)2.63681269
100negative regulation of cAMP-mediated signaling (GO:0043951)2.62181662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.84016146
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.79459432
3ZNF274_21170338_ChIP-Seq_K562_Hela3.21519017
4GBX2_23144817_ChIP-Seq_PC3_Human2.93425591
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90925268
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79541524
7EZH2_22144423_ChIP-Seq_EOC_Human2.74819096
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52553795
9FUS_26573619_Chip-Seq_HEK293_Human2.44869870
10VDR_22108803_ChIP-Seq_LS180_Human2.42537657
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40636638
12IGF1R_20145208_ChIP-Seq_DFB_Human2.38173250
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.21998975
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.21116968
15P300_19829295_ChIP-Seq_ESCs_Human2.19328182
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08900850
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01575185
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94568492
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93320574
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90342043
21TAF15_26573619_Chip-Seq_HEK293_Human1.88702936
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.87862704
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87670400
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87357821
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.87357821
26EWS_26573619_Chip-Seq_HEK293_Human1.87148296
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82540827
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82444487
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79908973
30SMAD4_21799915_ChIP-Seq_A2780_Human1.77961411
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75222622
32ER_23166858_ChIP-Seq_MCF-7_Human1.72992133
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62293708
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61669224
35TCF4_23295773_ChIP-Seq_U87_Human1.58378740
36STAT3_23295773_ChIP-Seq_U87_Human1.56936618
37NANOG_19829295_ChIP-Seq_ESCs_Human1.53545361
38SOX2_19829295_ChIP-Seq_ESCs_Human1.53545361
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49581229
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.48047565
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.47044584
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46861632
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.46538527
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46492899
45CBP_20019798_ChIP-Seq_JUKART_Human1.43733237
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43733237
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42902498
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42851552
49TCF4_22108803_ChIP-Seq_LS180_Human1.42604432
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40814389
51BCAT_22108803_ChIP-Seq_LS180_Human1.39712639
52CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.39636813
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.37907280
54AR_25329375_ChIP-Seq_VCAP_Human1.37313585
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35119056
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33562972
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33092902
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33003874
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.31187672
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29629486
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.27356670
62RUNX2_22187159_ChIP-Seq_PCA_Human1.27176009
63RNF2_27304074_Chip-Seq_NSC_Mouse1.25989563
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25628542
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24128618
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24005634
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23832184
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22925170
69P300_18555785_Chip-Seq_ESCs_Mouse1.21402426
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.20287130
71SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19982291
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.19911914
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.19548264
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18934092
75P53_22387025_ChIP-Seq_ESCs_Mouse1.13566799
76CDX2_22108803_ChIP-Seq_LS180_Human1.11798457
77CMYC_18555785_Chip-Seq_ESCs_Mouse1.10874608
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10411666
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09741476
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.08846008
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.06977360
82KDM2B_26808549_Chip-Seq_REH_Human1.06520992
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06015918
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04364164
85REST_21632747_ChIP-Seq_MESCs_Mouse1.03022388
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.02636385
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.02524891
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02182784
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01667314
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01325231
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01091926
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.00623648
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99570449
94FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99253210
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.97970693
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97970693
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97755243
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97407347
99KLF4_18555785_Chip-Seq_ESCs_Mouse0.95260112
100IRF1_19129219_ChIP-ChIP_H3396_Human0.94948062

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.70247154
2MP0002876_abnormal_thyroid_physiology3.37400184
3MP0001968_abnormal_touch/_nociception3.32718658
4MP0000372_irregular_coat_pigmentation3.30179119
5MP0003880_abnormal_central_pattern3.15026002
6MP0008057_abnormal_DNA_replication3.01553086
7MP0002735_abnormal_chemical_nociception2.84287046
8MP0005075_abnormal_melanosome_morpholog2.79357124
9MP0008877_abnormal_DNA_methylation2.58476258
10MP0002102_abnormal_ear_morphology2.57602234
11MP0003283_abnormal_digestive_organ2.49270417
12MP0000569_abnormal_digit_pigmentation2.45957828
13MP0005503_abnormal_tendon_morphology2.34383210
14MP0003136_yellow_coat_color2.29254750
15MP0002736_abnormal_nociception_after2.20279319
16MP0009046_muscle_twitch2.15361313
17MP0005423_abnormal_somatic_nervous1.93095692
18MP0001486_abnormal_startle_reflex1.84447518
19MP0006276_abnormal_autonomic_nervous1.77058492
20MP0005670_abnormal_white_adipose1.72883382
21MP0002272_abnormal_nervous_system1.69420393
22MP0004134_abnormal_chest_morphology1.69296297
23MP0002733_abnormal_thermal_nociception1.67922032
24MP0009745_abnormal_behavioral_response1.65142232
25MP0008058_abnormal_DNA_repair1.63708217
26MP0002751_abnormal_autonomic_nervous1.57888845
27MP0001177_atelectasis1.56508433
28MP0009250_abnormal_appendicular_skeleto1.55800268
29MP0005551_abnormal_eye_electrophysiolog1.54196765
30MP0003890_abnormal_embryonic-extraembry1.52700546
31MP0002638_abnormal_pupillary_reflex1.49910581
32MP0003718_maternal_effect1.46423411
33MP0000015_abnormal_ear_pigmentation1.45891334
34MP0004270_analgesia1.37987343
35MP0004924_abnormal_behavior1.36479146
36MP0005386_behavior/neurological_phenoty1.36479146
37MP0005174_abnormal_tail_pigmentation1.30136445
38MP0003183_abnormal_peptide_metabolism1.27818048
39MP0001485_abnormal_pinna_reflex1.21815318
40MP0002254_reproductive_system_inflammat1.17713579
41MP0001346_abnormal_lacrimal_gland1.17001718
42MP0002734_abnormal_mechanical_nocicepti1.14249482
43MP0002067_abnormal_sensory_capabilities1.10128055
44MP0010386_abnormal_urinary_bladder1.09673407
45MP0008775_abnormal_heart_ventricle1.06723852
46MP0001501_abnormal_sleep_pattern1.05028130
47MP0002234_abnormal_pharynx_morphology1.00514548
48MP0003635_abnormal_synaptic_transmissio0.99899370
49MP0005367_renal/urinary_system_phenotyp0.99644172
50MP0000516_abnormal_urinary_system0.99644172
51MP0009780_abnormal_chondrocyte_physiolo0.98149125
52MP0004742_abnormal_vestibular_system0.97699455
53MP0001970_abnormal_pain_threshold0.96234885
54MP0003937_abnormal_limbs/digits/tail_de0.96202147
55MP0003941_abnormal_skin_development0.94634712
56MP0003787_abnormal_imprinting0.93908528
57MP0002064_seizures0.92520431
58MP0003195_calcinosis0.90793119
59MP0002572_abnormal_emotion/affect_behav0.90298525
60MP0005171_absent_coat_pigmentation0.89332026
61MP0002184_abnormal_innervation0.83404257
62MP0009697_abnormal_copulation0.82068511
63MP0000371_diluted_coat_color0.80363647
64MP0004019_abnormal_vitamin_homeostasis0.79314114
65MP0002109_abnormal_limb_morphology0.79114035
66MP0000647_abnormal_sebaceous_gland0.75992200
67MP0006054_spinal_hemorrhage0.75721059
68MP0001963_abnormal_hearing_physiology0.74867760
69MP0000955_abnormal_spinal_cord0.74834227
70MP0005084_abnormal_gallbladder_morpholo0.72894545
71MP0001986_abnormal_taste_sensitivity0.72505656
72MP0005646_abnormal_pituitary_gland0.72194104
73MP0002938_white_spotting0.70296603
74MP0001929_abnormal_gametogenesis0.69823417
75MP0000230_abnormal_systemic_arterial0.69647730
76MP0001881_abnormal_mammary_gland0.69628367
77MP0002557_abnormal_social/conspecific_i0.68835176
78MP0008770_decreased_survivor_rate0.67969745
79MP0008872_abnormal_physiological_respon0.67902529
80MP0002177_abnormal_outer_ear0.67820110
81MP0005167_abnormal_blood-brain_barrier0.67776029
82MP0002229_neurodegeneration0.67361728
83MP0002210_abnormal_sex_determination0.67078320
84MP0003959_abnormal_lean_body0.66636664
85MP0002148_abnormal_hypersensitivity_rea0.65595746
86MP0005508_abnormal_skeleton_morphology0.65306630
87MP0002160_abnormal_reproductive_system0.65163193
88MP0000427_abnormal_hair_cycle0.64982354
89MP0009703_decreased_birth_body0.64732039
90MP0000681_abnormal_thyroid_gland0.64394086
91MP0002063_abnormal_learning/memory/cond0.63987158
92MP0005253_abnormal_eye_physiology0.63641196
93MP0003698_abnormal_male_reproductive0.63367983
94MP0002075_abnormal_coat/hair_pigmentati0.62969849
95MP0002282_abnormal_trachea_morphology0.62732510
96MP0003633_abnormal_nervous_system0.62236178
97MP0001188_hyperpigmentation0.61739000
98MP0000678_abnormal_parathyroid_gland0.61649970
99MP0006082_CNS_inflammation0.61523633
100MP0000749_muscle_degeneration0.61383375

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal dysplasia (HP:0100255)5.17128226
2Type II lissencephaly (HP:0007260)3.89777338
3Long clavicles (HP:0000890)3.86123737
4Broad alveolar ridges (HP:0000187)3.68822880
5Hepatoblastoma (HP:0002884)3.65466822
6Volvulus (HP:0002580)3.49437387
7Cerebellar dysplasia (HP:0007033)3.43259955
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.32109296
9Abnormality of the labia minora (HP:0012880)3.27277692
10Abnormality of the pubic bones (HP:0003172)3.25744953
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.17837151
12Aplasia/Hypoplasia of the sternum (HP:0006714)3.17110491
13Visual hallucinations (HP:0002367)3.14398776
14Pancreatic fibrosis (HP:0100732)3.09522645
15Hyperventilation (HP:0002883)2.94057470
16Short middle phalanx of the 5th finger (HP:0004220)2.90494234
17Chromsome breakage (HP:0040012)2.87575004
18Hypoplastic ischia (HP:0003175)2.81495926
19Facial hemangioma (HP:0000329)2.78009375
20Absent frontal sinuses (HP:0002688)2.76930447
21Peripheral hypomyelination (HP:0007182)2.73917976
22Pancreatic cysts (HP:0001737)2.72898576
23Hypoplasia of the pons (HP:0012110)2.72472515
24Hypoplastic iliac wings (HP:0002866)2.67888217
25Impulsivity (HP:0100710)2.63681768
26Neonatal respiratory distress (HP:0002643)2.62575096
27Increased number of teeth (HP:0011069)2.61352219
28Testicular atrophy (HP:0000029)2.60559552
29Abnormality of the ileum (HP:0001549)2.55004622
30Gaze-evoked nystagmus (HP:0000640)2.53947666
31Focal seizures (HP:0007359)2.53132444
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.52070606
33Decreased skull ossification (HP:0004331)2.51456189
34Tubular atrophy (HP:0000092)2.46185622
35Absent thumb (HP:0009777)2.43260582
36Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.43199219
37Intestinal atresia (HP:0011100)2.41400565
38Optic nerve hypoplasia (HP:0000609)2.39513857
39Adactyly (HP:0009776)2.35403033
40Short ribs (HP:0000773)2.33647392
41Oligodactyly (hands) (HP:0001180)2.31795084
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30467079
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.28841970
44Small hand (HP:0200055)2.27217501
45Sclerocornea (HP:0000647)2.27035843
46Abnormality of the pons (HP:0007361)2.26149844
47Abnormality of the ischium (HP:0003174)2.25548122
48Anencephaly (HP:0002323)2.22869364
49Abolished electroretinogram (ERG) (HP:0000550)2.21801352
50Lissencephaly (HP:0001339)2.21271354
51Long nose (HP:0003189)2.20392776
52Decreased central vision (HP:0007663)2.19458763
53Dialeptic seizures (HP:0011146)2.19190429
54Abnormality of the frontal sinuses (HP:0002687)2.19062163
55Abnormality of the alveolar ridges (HP:0006477)2.18153671
56Short phalanx of the thumb (HP:0009660)2.17527162
57Protruding tongue (HP:0010808)2.15751144
58Opisthotonus (HP:0002179)2.14393647
59Inability to walk (HP:0002540)2.14267667
60Focal motor seizures (HP:0011153)2.14065880
61Autoamputation (HP:0001218)2.13482464
62Hypoplastic labia majora (HP:0000059)2.13338967
63Tapered finger (HP:0001182)2.11169829
64True hermaphroditism (HP:0010459)2.09923351
65Meckel diverticulum (HP:0002245)2.08589460
66Medial flaring of the eyebrow (HP:0010747)2.07983086
67Pendular nystagmus (HP:0012043)2.06654034
68Abnormality of chromosome stability (HP:0003220)2.06459868
69Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.06038254
70Short tibia (HP:0005736)2.00489773
71Increased density of long bones (HP:0006392)1.99827371
72Congenital stationary night blindness (HP:0007642)1.99822428
73Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97588040
74Short 1st metacarpal (HP:0010034)1.97588040
75Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.96009074
76Degeneration of the lateral corticospinal tracts (HP:0002314)1.95578959
77Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.95578959
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93896682
79Progressive inability to walk (HP:0002505)1.92058682
80Spondylolisthesis (HP:0003302)1.91829994
81Abnormality of the parietal bone (HP:0002696)1.91746819
82Distal arthrogryposis (HP:0005684)1.91301926
83Sloping forehead (HP:0000340)1.90025154
84Disproportionate short-trunk short stature (HP:0003521)1.89862077
85Abnormality of the labia majora (HP:0012881)1.89753260
86Increased corneal curvature (HP:0100692)1.89354505
87Keratoconus (HP:0000563)1.89354505
88Neurodegeneration (HP:0002180)1.89081515
89Large earlobe (HP:0009748)1.87277824
90Status epilepticus (HP:0002133)1.86143174
91Abnormality of the renal cortex (HP:0011035)1.85994741
92Gastrointestinal atresia (HP:0002589)1.83175589
93Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.82911471
94Abnormality of macular pigmentation (HP:0008002)1.78968089
95Megalencephaly (HP:0001355)1.78451653
96Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.76374482
97Dandy-Walker malformation (HP:0001305)1.76273854
98Thyroid-stimulating hormone excess (HP:0002925)1.75838020
99Amyotrophic lateral sclerosis (HP:0007354)1.75767800
100Abnormality of skull ossification (HP:0002703)1.75725767

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K27.88201756
2PINK15.33163049
3FRK3.35348879
4ADRBK23.19956550
5STK392.86249316
6PNCK2.43032409
7TNIK2.36566532
8MARK32.15025544
9TAOK32.09001988
10ZAK2.07220559
11MAP3K62.04804120
12OXSR11.95821370
13ACVR1B1.82987117
14MAPKAPK31.82587844
15NUAK11.69106167
16MAPK131.66883045
17MARK11.62447530
18DYRK31.49560838
19WNK31.48627100
20WEE11.41229580
21INSRR1.38787491
22CAMK1G1.27720280
23IRAK11.24558910
24MAP3K121.23281639
25MUSK1.19905709
26BMPR1B1.08626565
27NEK61.00622037
28TIE10.97992194
29GRK10.91879389
30KIT0.90391893
31ADRBK10.88148697
32PAK30.85494047
33PRKCI0.84838852
34EEF2K0.83687267
35PRKCG0.81233870
36DYRK1A0.78384298
37CSNK1G10.77574395
38PBK0.76224879
39STK240.71796862
40PRKCE0.71777487
41PIK3CA0.71765521
42TEC0.71356933
43MAPKAPK50.68255107
44BCR0.66657831
45CAMK1D0.66176624
46WNK40.64429419
47SIK20.63902647
48CSNK1D0.63863881
49CCNB10.63239236
50BUB10.61901134
51MAP3K40.60507700
52MINK10.60021480
53STK30.58764466
54PLK10.57983088
55NTRK20.56229144
56DAPK20.54754737
57PLK30.54669226
58TRPM70.54165873
59CSNK1G30.51065771
60EIF2AK30.49506775
61CSNK1G20.49181918
62DYRK20.48789223
63TNK20.48675003
64CHUK0.48325534
65MAP2K40.47999354
66NME10.45314883
67SRPK10.44726122
68VRK10.44253829
69PRKCH0.41076892
70PRKACA0.41051260
71MAP2K70.39698997
72BCKDK0.39048048
73CSNK1A10.38768523
74CDK190.38674657
75ATM0.38422533
76PRKCZ0.38409009
77TGFBR10.38171806
78MAPK110.37085665
79CHEK20.36761944
80OBSCN0.36141648
81JAK10.36062141
82STK110.35761547
83ATR0.35741678
84CSNK1E0.35049438
85MAPK80.35019029
86DAPK10.34904171
87PRKG10.34168051
88CAMK2A0.33440451
89PRKAA20.32854175
90PTK2B0.32571519
91STK38L0.32394436
92FER0.30531536
93TXK0.30461332
94PKN10.30216329
95IRAK20.29683467
96STK380.29306407
97CSF1R0.29109749
98NLK0.28906961
99FLT30.28404049
100ERBB30.26933344

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.03233279
2Non-homologous end-joining_Homo sapiens_hsa034502.76143323
3Homologous recombination_Homo sapiens_hsa034402.61904776
4Nicotine addiction_Homo sapiens_hsa050332.56746198
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33729556
6Phototransduction_Homo sapiens_hsa047442.31215613
7Propanoate metabolism_Homo sapiens_hsa006402.30145546
8Protein export_Homo sapiens_hsa030602.26255985
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.23398232
10Linoleic acid metabolism_Homo sapiens_hsa005912.17299996
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.11386686
12Butanoate metabolism_Homo sapiens_hsa006501.99564054
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96524566
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81877624
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71522285
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.71078083
17Olfactory transduction_Homo sapiens_hsa047401.64277022
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.63092153
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60759221
20Basal transcription factors_Homo sapiens_hsa030221.59650843
21African trypanosomiasis_Homo sapiens_hsa051431.58168551
22Nitrogen metabolism_Homo sapiens_hsa009101.56063241
23Taste transduction_Homo sapiens_hsa047421.50693271
24Tryptophan metabolism_Homo sapiens_hsa003801.49127366
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40088358
26RNA polymerase_Homo sapiens_hsa030201.39969489
27Arachidonic acid metabolism_Homo sapiens_hsa005901.37752176
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33359161
29One carbon pool by folate_Homo sapiens_hsa006701.32224919
30Pyruvate metabolism_Homo sapiens_hsa006201.24648837
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23450101
32Caffeine metabolism_Homo sapiens_hsa002321.23296227
33Glutamatergic synapse_Homo sapiens_hsa047241.22582912
34Ether lipid metabolism_Homo sapiens_hsa005651.22527177
35Dorso-ventral axis formation_Homo sapiens_hsa043201.21958262
36Chemical carcinogenesis_Homo sapiens_hsa052041.18639763
37Long-term depression_Homo sapiens_hsa047301.14225111
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13255517
39Circadian entrainment_Homo sapiens_hsa047131.10310103
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09608105
41Selenocompound metabolism_Homo sapiens_hsa004501.07865336
42Salivary secretion_Homo sapiens_hsa049701.07237513
43Serotonergic synapse_Homo sapiens_hsa047261.06208586
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05300664
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01042242
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00014386
47RNA degradation_Homo sapiens_hsa030180.97079487
48Amphetamine addiction_Homo sapiens_hsa050310.96647973
49Proteasome_Homo sapiens_hsa030500.96525827
50Type I diabetes mellitus_Homo sapiens_hsa049400.95824066
51Dopaminergic synapse_Homo sapiens_hsa047280.92535060
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.92195423
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85228454
54Retinol metabolism_Homo sapiens_hsa008300.80437733
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80353371
56Circadian rhythm_Homo sapiens_hsa047100.78344710
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77788592
58Allograft rejection_Homo sapiens_hsa053300.75396132
59Asthma_Homo sapiens_hsa053100.74620245
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.73991139
61Purine metabolism_Homo sapiens_hsa002300.69426219
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69336940
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69259775
64Axon guidance_Homo sapiens_hsa043600.69208705
65Hedgehog signaling pathway_Homo sapiens_hsa043400.69161539
66Pyrimidine metabolism_Homo sapiens_hsa002400.68926026
67p53 signaling pathway_Homo sapiens_hsa041150.68310536
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68151916
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67342752
70Basal cell carcinoma_Homo sapiens_hsa052170.67197682
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.66084916
72Peroxisome_Homo sapiens_hsa041460.65406700
73Morphine addiction_Homo sapiens_hsa050320.64091772
74Sphingolipid metabolism_Homo sapiens_hsa006000.62020267
75Glutathione metabolism_Homo sapiens_hsa004800.60090990
76ABC transporters_Homo sapiens_hsa020100.60087358
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59298857
78Renin secretion_Homo sapiens_hsa049240.58585806
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.57229000
80Cardiac muscle contraction_Homo sapiens_hsa042600.56179094
81Cocaine addiction_Homo sapiens_hsa050300.56120818
82beta-Alanine metabolism_Homo sapiens_hsa004100.54782256
83Glycerolipid metabolism_Homo sapiens_hsa005610.51638396
84Calcium signaling pathway_Homo sapiens_hsa040200.47894370
85Starch and sucrose metabolism_Homo sapiens_hsa005000.47320782
86mRNA surveillance pathway_Homo sapiens_hsa030150.47083194
87Nucleotide excision repair_Homo sapiens_hsa034200.45660316
88Histidine metabolism_Homo sapiens_hsa003400.44845892
89Base excision repair_Homo sapiens_hsa034100.42834070
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42575447
91Fatty acid biosynthesis_Homo sapiens_hsa000610.42306729
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41525888
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39074101
94Oxytocin signaling pathway_Homo sapiens_hsa049210.38955569
95Fatty acid degradation_Homo sapiens_hsa000710.37820974
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37507190
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.35669852
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35447475
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34093265
100Cell cycle_Homo sapiens_hsa041100.31686533

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