SRSF11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.91972948
2DNA replication checkpoint (GO:0000076)4.65923291
3mRNA splice site selection (GO:0006376)4.40480969
4negative regulation of neurotransmitter secretion (GO:0046929)4.30395654
5mitotic sister chromatid cohesion (GO:0007064)4.05036785
6kinetochore organization (GO:0051383)3.84934924
7replication fork processing (GO:0031297)3.79839505
8peptidyl-lysine trimethylation (GO:0018023)3.71325671
9histone H3-K9 methylation (GO:0051567)3.65101498
10negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.63567044
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62453412
12negative regulation of RNA splicing (GO:0033119)3.62004808
13DNA topological change (GO:0006265)3.53958558
14histone H3-K4 methylation (GO:0051568)3.51742297
15DNA unwinding involved in DNA replication (GO:0006268)3.47527147
16negative regulation of DNA-dependent DNA replication (GO:2000104)3.42501646
17kinetochore assembly (GO:0051382)3.38886830
18regulation of nuclear cell cycle DNA replication (GO:0033262)3.33495494
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.33331837
20monoubiquitinated protein deubiquitination (GO:0035520)3.32333044
21negative regulation of mRNA processing (GO:0050686)3.30116048
22positive regulation of histone H3-K4 methylation (GO:0051571)3.28424559
23alternative mRNA splicing, via spliceosome (GO:0000380)3.23500091
24regulation of DNA endoreduplication (GO:0032875)3.23493679
25regulation of histone H3-K4 methylation (GO:0051569)3.19963911
26histone H3-K9 modification (GO:0061647)3.17700329
27mitotic G2/M transition checkpoint (GO:0044818)3.16879091
28regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12272800
29regulation of mitotic spindle checkpoint (GO:1903504)3.12272800
30regulation of centriole replication (GO:0046599)3.09565682
31somite development (GO:0061053)3.09362455
32negative regulation of translation, ncRNA-mediated (GO:0040033)3.06772491
33regulation of translation, ncRNA-mediated (GO:0045974)3.06772491
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06772491
35negative regulation of neurotransmitter transport (GO:0051589)3.04850064
36poly(A)+ mRNA export from nucleus (GO:0016973)3.01248750
37histone exchange (GO:0043486)3.00761018
38histone H2A acetylation (GO:0043968)3.00106089
39nuclear pore complex assembly (GO:0051292)2.99385327
40microtubule anchoring (GO:0034453)2.96303177
41sister chromatid segregation (GO:0000819)2.93842060
42resolution of meiotic recombination intermediates (GO:0000712)2.92727352
43negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91052496
44negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91052496
45negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91052496
46negative regulation of mitotic sister chromatid separation (GO:2000816)2.91052496
47negative regulation of sister chromatid segregation (GO:0033046)2.91052496
48regulation of mRNA splicing, via spliceosome (GO:0048024)2.90018777
49histone lysine methylation (GO:0034968)2.88897732
50neural tube formation (GO:0001841)2.87752222
51synapsis (GO:0007129)2.86923461
52peptidyl-lysine methylation (GO:0018022)2.86260933
53negative regulation of chromosome segregation (GO:0051985)2.83385069
54positive regulation of amino acid transport (GO:0051957)2.82255268
55DNA geometric change (GO:0032392)2.79852203
56DNA duplex unwinding (GO:0032508)2.79198788
57negative regulation of mRNA metabolic process (GO:1903312)2.78430373
58translational termination (GO:0006415)2.77681143
59nuclear pore organization (GO:0006999)2.77315326
60pre-miRNA processing (GO:0031054)2.75419935
61regulation of histone H3-K27 methylation (GO:0061085)2.75300882
62interkinetic nuclear migration (GO:0022027)2.73963078
63regulation of histone methylation (GO:0031060)2.72203355
64otic vesicle formation (GO:0030916)2.70486786
65viral transcription (GO:0019083)2.70467093
66regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.70345565
67negative regulation of DNA recombination (GO:0045910)2.70262083
68maturation of SSU-rRNA (GO:0030490)2.69161943
69mitotic G2 DNA damage checkpoint (GO:0007095)2.68858999
70mitotic spindle assembly checkpoint (GO:0007094)2.68727964
71regulation of mRNA processing (GO:0050684)2.68171278
72DNA strand renaturation (GO:0000733)2.66968484
73spindle assembly checkpoint (GO:0071173)2.65816965
74reciprocal DNA recombination (GO:0035825)2.64698855
75reciprocal meiotic recombination (GO:0007131)2.64698855
76DNA replication initiation (GO:0006270)2.64006316
77regulation of RNA splicing (GO:0043484)2.63827401
78regulation of mitotic sister chromatid separation (GO:0010965)2.63447674
79regulation of mitotic sister chromatid segregation (GO:0033047)2.63447674
80regulation of sister chromatid segregation (GO:0033045)2.63447674
81histone methylation (GO:0016571)2.63176162
82regulation of RNA export from nucleus (GO:0046831)2.63069297
83centrosome organization (GO:0051297)2.62984900
84* mRNA splicing, via spliceosome (GO:0000398)2.61502061
85* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.61502061
86regulation of telomere maintenance (GO:0032204)2.60883238
87mitotic spindle checkpoint (GO:0071174)2.60468719
88V(D)J recombination (GO:0033151)2.59755814
89nucleosome disassembly (GO:0006337)2.59534444
90protein-DNA complex disassembly (GO:0032986)2.59534444
91DNA replication-independent nucleosome assembly (GO:0006336)2.59287034
92DNA replication-independent nucleosome organization (GO:0034724)2.59287034
93mitotic sister chromatid segregation (GO:0000070)2.59174333
94mitotic recombination (GO:0006312)2.59135331
95* RNA splicing, via transesterification reactions (GO:0000375)2.59040798
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.57914046
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.57914046
98positive regulation of histone methylation (GO:0031062)2.57688844
99head development (GO:0060322)2.57301162
100DNA ligation (GO:0006266)2.56879619
101negative regulation of histone methylation (GO:0031061)2.56709160
102telomere maintenance via telomerase (GO:0007004)2.56530359
103positive regulation of RNA splicing (GO:0033120)2.56520358
104regulation of helicase activity (GO:0051095)2.55915549
105spindle checkpoint (GO:0031577)2.54864294
106attachment of spindle microtubules to kinetochore (GO:0008608)2.54746193
107ribosomal small subunit assembly (GO:0000028)2.54555937
108* termination of RNA polymerase II transcription (GO:0006369)2.54507291
109meiotic chromosome segregation (GO:0045132)2.54389833
110microtubule organizing center organization (GO:0031023)2.54145341
111telomere maintenance via semi-conservative replication (GO:0032201)2.53944912
112DNA strand elongation involved in DNA replication (GO:0006271)2.52699115
113regulation of centrosome duplication (GO:0010824)2.51485039
114telomere maintenance via recombination (GO:0000722)2.49582817
115regulation of mRNA metabolic process (GO:1903311)2.49485093
116definitive hemopoiesis (GO:0060216)2.48601459
117presynaptic membrane assembly (GO:0097105)2.48171014
118double-strand break repair via homologous recombination (GO:0000724)2.47634816
119spliceosomal complex assembly (GO:0000245)2.46853935
120recombinational repair (GO:0000725)2.46806210
121centriole assembly (GO:0098534)2.45450481
122chromatin remodeling at centromere (GO:0031055)2.44669796
123* mRNA export from nucleus (GO:0006406)2.44352335
124CENP-A containing nucleosome assembly (GO:0034080)2.43605505
125DNA strand elongation (GO:0022616)2.43596210
126centriole replication (GO:0007099)2.42937416
127regulation of histone H3-K9 methylation (GO:0051570)2.41483312
128* RNA export from nucleus (GO:0006405)2.39723666
129regulation of DNA-dependent DNA replication (GO:0090329)2.38544616
130DNA conformation change (GO:0071103)2.38073002
131establishment of mitotic spindle orientation (GO:0000132)2.37568961
132positive regulation of granulocyte differentiation (GO:0030854)2.36775540
133maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.36426529
134RNA-dependent DNA replication (GO:0006278)2.35374110
135positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.35142450
136positive regulation of cell cycle G2/M phase transition (GO:1902751)2.35142450
137protein localization to kinetochore (GO:0034501)2.34729839
138mitotic metaphase plate congression (GO:0007080)2.33786538
139telomere maintenance via telomere lengthening (GO:0010833)2.32510968
140regulation of DNA damage checkpoint (GO:2000001)2.31771526
141viral mRNA export from host cell nucleus (GO:0046784)2.31425222
142pore complex assembly (GO:0046931)2.31163392
143metaphase plate congression (GO:0051310)2.31044187
144positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.30881911
145ATP-dependent chromatin remodeling (GO:0043044)2.30741209
146* RNA splicing (GO:0008380)2.30297454
147intra-S DNA damage checkpoint (GO:0031573)2.29377260
148regulation of stem cell maintenance (GO:2000036)2.28625588
149histone H4-K16 acetylation (GO:0043984)2.28391088
150sister chromatid cohesion (GO:0007062)2.28135677
151chromatin assembly or disassembly (GO:0006333)2.27493874
152somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.27115944
153somatic cell DNA recombination (GO:0016444)2.27115944
154dosage compensation (GO:0007549)2.26918215
155mismatch repair (GO:0006298)2.26595963
156histone deubiquitination (GO:0016578)2.26259370
157translesion synthesis (GO:0019985)2.25449394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.67636010
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.19979602
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02320950
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.84446812
5TP63_19390658_ChIP-ChIP_HaCaT_Human3.39867776
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.04703323
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.90030356
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65948258
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.52949321
10IGF1R_20145208_ChIP-Seq_DFB_Human2.52800797
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.41224470
12CIITA_25753668_ChIP-Seq_RAJI_Human2.39824009
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25086609
14ZNF274_21170338_ChIP-Seq_K562_Hela2.22683712
15VDR_22108803_ChIP-Seq_LS180_Human2.18166590
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11266980
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09391592
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01646488
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.99332118
20EWS_26573619_Chip-Seq_HEK293_Human1.94907169
21SCL_19346495_ChIP-Seq_HPC-7_Human1.93405610
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91527047
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84725145
24MYC_22102868_ChIP-Seq_BL_Human1.82944271
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.82647527
26FUS_26573619_Chip-Seq_HEK293_Human1.80548277
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.78326364
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.78082016
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.75810874
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73746148
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72699818
32EZH2_22144423_ChIP-Seq_EOC_Human1.71074467
33RNF2_27304074_Chip-Seq_NSC_Mouse1.70582857
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69960834
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66952993
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66156842
37P300_19829295_ChIP-Seq_ESCs_Human1.62966562
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59251249
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59062996
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54642533
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54077876
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.52866014
43ELK1_19687146_ChIP-ChIP_HELA_Human1.51454550
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49734325
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48536490
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48441587
47* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45558420
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42424356
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38026526
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37223006
51GBX2_23144817_ChIP-Seq_PC3_Human1.36551406
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36258452
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35910724
54VDR_23849224_ChIP-Seq_CD4+_Human1.34078837
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31743013
56TTF2_22483619_ChIP-Seq_HELA_Human1.30654067
57FOXP3_21729870_ChIP-Seq_TREG_Human1.30452760
58ER_23166858_ChIP-Seq_MCF-7_Human1.29693381
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28345596
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27508217
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27379941
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26812701
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.24460847
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24289398
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20947797
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19964693
67XRN2_22483619_ChIP-Seq_HELA_Human1.19674479
68VDR_21846776_ChIP-Seq_THP-1_Human1.18311608
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17654050
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17268595
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17110407
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16604778
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16128808
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15174716
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14839008
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14302173
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12952288
78SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12606682
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12455557
80GATA1_22025678_ChIP-Seq_K562_Human1.12248841
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10449756
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09574593
83MYB_26560356_Chip-Seq_TH1_Human1.08103681
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08097526
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07067236
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06947065
87STAT3_23295773_ChIP-Seq_U87_Human1.06828799
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06566919
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06532317
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.06325163
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06135575
92TCF4_23295773_ChIP-Seq_U87_Human1.05677952
93RUNX2_22187159_ChIP-Seq_PCA_Human1.05005530
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04439653
95BCAT_22108803_ChIP-Seq_LS180_Human1.03340205
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03313507
97KDM5A_27292631_Chip-Seq_BREAST_Human1.03114659
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02575238
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02454933
100CBP_20019798_ChIP-Seq_JUKART_Human1.02454933
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01667507
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01454764
103SPI1_23547873_ChIP-Seq_NB4_Human1.00979267
104AR_21572438_ChIP-Seq_LNCaP_Human1.00128112
105AR_21909140_ChIP-Seq_LNCAP_Human0.99711111
106SMAD4_21799915_ChIP-Seq_A2780_Human0.99703134
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.98571518
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98523838
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97776996
110MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97655592
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97569023
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97192713
113MYC_18940864_ChIP-ChIP_HL60_Human0.97028985
114SMAD3_21741376_ChIP-Seq_EPCs_Human0.96743672
115TP53_16413492_ChIP-PET_HCT116_Human0.95301139
116POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95106757
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94417916
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94049664
119P53_22387025_ChIP-Seq_ESCs_Mouse0.93950984
120LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93572324
121MYB_26560356_Chip-Seq_TH2_Human0.93398370
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92739580
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.92713219
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92612593
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.92381959
126TCF4_22108803_ChIP-Seq_LS180_Human0.90897046
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90716374
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.89861800
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88784140
130TCF7_22412390_ChIP-Seq_EML_Mouse0.88136209
131HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86102370
132CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85863966
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85564158
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.84506115
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83631033
136IRF1_19129219_ChIP-ChIP_H3396_Human0.83547615
137IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81344619
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80066749
139RUNX_20019798_ChIP-Seq_JUKART_Human0.79480390
140ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77336443
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76875798
142ETS1_20019798_ChIP-Seq_JURKAT_Human0.76642736
143CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76157240
144MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.74458331
145UTX_26944678_Chip-Seq_JUKART_Human0.72494106
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71736335
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71736335
148SOX9_26525672_Chip-Seq_HEART_Mouse0.70890832
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.70449589
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69894154
151TAF15_26573619_Chip-Seq_HEK293_Human0.68808646
152VDR_24763502_ChIP-Seq_THP-1_Human0.67558122
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67459892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.49566885
2MP0006292_abnormal_olfactory_placode3.23533841
3MP0008057_abnormal_DNA_replication2.88734398
4MP0000569_abnormal_digit_pigmentation2.80572041
5MP0010094_abnormal_chromosome_stability2.68589597
6MP0003111_abnormal_nucleus_morphology2.56971572
7MP0003121_genomic_imprinting2.49040324
8MP0002396_abnormal_hematopoietic_system2.39863885
9MP0003693_abnormal_embryo_hatching2.35736163
10MP0005409_darkened_coat_color2.33534658
11MP0008877_abnormal_DNA_methylation2.28098793
12MP0005174_abnormal_tail_pigmentation2.19001141
13MP0008058_abnormal_DNA_repair2.13241527
14MP0003077_abnormal_cell_cycle2.07000009
15MP0008007_abnormal_cellular_replicative2.05184347
16MP0001188_hyperpigmentation2.02905085
17MP0003123_paternal_imprinting1.99061819
18MP0009379_abnormal_foot_pigmentation1.98287390
19MP0002822_catalepsy1.89536147
20MP0004957_abnormal_blastocyst_morpholog1.85717273
21MP0008961_abnormal_basal_metabolism1.84475350
22MP0004808_abnormal_hematopoietic_stem1.78744847
23MP0000049_abnormal_middle_ear1.72962092
24MP0000015_abnormal_ear_pigmentation1.61853533
25MP0003122_maternal_imprinting1.56676428
26MP0003763_abnormal_thymus_physiology1.56031658
27MP0000566_synostosis1.55775411
28MP0002938_white_spotting1.54591648
29MP0003880_abnormal_central_pattern1.54516919
30MP0003890_abnormal_embryonic-extraembry1.40456542
31MP0003937_abnormal_limbs/digits/tail_de1.37964550
32MP0000703_abnormal_thymus_morphology1.35962211
33MP0002095_abnormal_skin_pigmentation1.32955642
34MP0010030_abnormal_orbit_morphology1.30440934
35MP0008932_abnormal_embryonic_tissue1.27778715
36MP0000350_abnormal_cell_proliferation1.23953451
37MP0002102_abnormal_ear_morphology1.23466901
38MP0001293_anophthalmia1.23110336
39MP0001529_abnormal_vocalization1.22071757
40MP0001984_abnormal_olfaction1.21920646
41MP0002249_abnormal_larynx_morphology1.20227909
42MP0003935_abnormal_craniofacial_develop1.19725791
43MP0003938_abnormal_ear_development1.18965552
44MP0005551_abnormal_eye_electrophysiolog1.16405099
45MP0003136_yellow_coat_color1.15949178
46MP0002210_abnormal_sex_determination1.15686416
47MP0002177_abnormal_outer_ear1.13324715
48MP0002009_preneoplasia1.11908104
49MP0002398_abnormal_bone_marrow1.09933108
50MP0000490_abnormal_crypts_of1.09000269
51MP0003755_abnormal_palate_morphology1.07007389
52MP0003385_abnormal_body_wall1.06715351
53MP0000428_abnormal_craniofacial_morphol1.06685834
54MP0004197_abnormal_fetal_growth/weight/1.05634635
55MP0002084_abnormal_developmental_patter1.05495459
56MP0001485_abnormal_pinna_reflex1.04415313
57MP0002735_abnormal_chemical_nociception1.04046125
58MP0008789_abnormal_olfactory_epithelium1.04027029
59MP0000678_abnormal_parathyroid_gland1.03878024
60MP0002184_abnormal_innervation1.03222618
61MP0000432_abnormal_head_morphology1.01453861
62MP0009250_abnormal_appendicular_skeleto1.00681287
63MP0000631_abnormal_neuroendocrine_gland1.00647038
64MP0006054_spinal_hemorrhage0.99619046
65MP0002085_abnormal_embryonic_tissue0.98244628
66MP0005394_taste/olfaction_phenotype0.98145965
67MP0005499_abnormal_olfactory_system0.98145965
68MP0001929_abnormal_gametogenesis0.97810495
69MP0002116_abnormal_craniofacial_bone0.97800095
70MP0003943_abnormal_hepatobiliary_system0.97059500
71MP0001145_abnormal_male_reproductive0.96894086
72MP0003786_premature_aging0.96847871
73MP0003315_abnormal_perineum_morphology0.94607571
74MP0008995_early_reproductive_senescence0.94537307
75MP0005075_abnormal_melanosome_morpholog0.93957465
76MP0004133_heterotaxia0.93703714
77MP0000653_abnormal_sex_gland0.93647164
78MP0001486_abnormal_startle_reflex0.93596369
79MP0003698_abnormal_male_reproductive0.92813294
80MP0003567_abnormal_fetal_cardiomyocyte0.91800554
81MP0009697_abnormal_copulation0.91372223
82MP0004885_abnormal_endolymph0.91049541
83MP0002160_abnormal_reproductive_system0.90345539
84MP0001697_abnormal_embryo_size0.89348722
85MP0004142_abnormal_muscle_tone0.89161484
86MP0001672_abnormal_embryogenesis/_devel0.88772464
87MP0005380_embryogenesis_phenotype0.88772464
88MP0009703_decreased_birth_body0.87710835
89MP0000383_abnormal_hair_follicle0.87520239
90MP0002932_abnormal_joint_morphology0.87153468
91MP0002233_abnormal_nose_morphology0.85336049
92MP0002751_abnormal_autonomic_nervous0.85203429
93MP0003283_abnormal_digestive_organ0.84142821
94MP0005671_abnormal_response_to0.83807229
95MP0002114_abnormal_axial_skeleton0.83377303
96MP0002697_abnormal_eye_size0.83205814
97MP0003861_abnormal_nervous_system0.83035631
98MP0000955_abnormal_spinal_cord0.82485276
99MP0000537_abnormal_urethra_morphology0.82335709
100MP0005076_abnormal_cell_differentiation0.82256073
101MP0000313_abnormal_cell_death0.81921154
102MP0002928_abnormal_bile_duct0.81915357
103MP0003119_abnormal_digestive_system0.81614507
104MP0005253_abnormal_eye_physiology0.81548367
105MP0001286_abnormal_eye_development0.81315933
106MP0002075_abnormal_coat/hair_pigmentati0.81210233
107MP0002722_abnormal_immune_system0.80745624
108MP0002272_abnormal_nervous_system0.80615890
109MP0002557_abnormal_social/conspecific_i0.79908895
110MP0002166_altered_tumor_susceptibility0.79147682
111MP0003984_embryonic_growth_retardation0.78882843
112MP0002752_abnormal_somatic_nervous0.78286545
113MP0001119_abnormal_female_reproductive0.78207131
114MP0005389_reproductive_system_phenotype0.77446146
115MP0001730_embryonic_growth_arrest0.77408352
116MP0009745_abnormal_behavioral_response0.77376559
117MP0010307_abnormal_tumor_latency0.77078299
118MP0006072_abnormal_retinal_apoptosis0.76988276
119MP0002088_abnormal_embryonic_growth/wei0.76817987
120MP0003718_maternal_effect0.75372856
121MP0002163_abnormal_gland_morphology0.74580530
122MP0006276_abnormal_autonomic_nervous0.74249445
123MP0002081_perinatal_lethality0.74072901
124MP0004742_abnormal_vestibular_system0.74044674
125MP0005195_abnormal_posterior_eye0.74019695
126MP0002109_abnormal_limb_morphology0.74000620
127MP0005391_vision/eye_phenotype0.73949290
128MP0002234_abnormal_pharynx_morphology0.73949152
129MP0000716_abnormal_immune_system0.73690393
130MP0003635_abnormal_synaptic_transmissio0.72708045
131MP0001800_abnormal_humoral_immune0.72501992
132MP0000689_abnormal_spleen_morphology0.72495492
133MP0002152_abnormal_brain_morphology0.72069141
134MP0002086_abnormal_extraembryonic_tissu0.71802986
135MP0002080_prenatal_lethality0.69917754
136MP0003115_abnormal_respiratory_system0.69408034
137MP0000778_abnormal_nervous_system0.68572384
138MP0009672_abnormal_birth_weight0.68334650
139MP0002006_tumorigenesis0.68090236
140MP0002092_abnormal_eye_morphology0.67742444

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.41451525
2Abnormality of the labia minora (HP:0012880)3.17593651
3Abnormality of the fingertips (HP:0001211)3.11736713
4Syringomyelia (HP:0003396)3.01439805
5Spinal cord lesions (HP:0100561)3.01439805
6Chromsome breakage (HP:0040012)2.95931109
7Absent frontal sinuses (HP:0002688)2.92583963
8Supernumerary ribs (HP:0005815)2.83533257
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.81439410
10Acute lymphatic leukemia (HP:0006721)2.76710751
11Medulloblastoma (HP:0002885)2.73111684
12Supernumerary bones of the axial skeleton (HP:0009144)2.72696106
13Abnormality of the parietal bone (HP:0002696)2.68583782
14Pancreatic fibrosis (HP:0100732)2.68407674
15Nephronophthisis (HP:0000090)2.61747511
16Medial flaring of the eyebrow (HP:0010747)2.51095719
17Abnormal number of incisors (HP:0011064)2.49133083
18Birth length less than 3rd percentile (HP:0003561)2.48967680
19Nephroblastoma (Wilms tumor) (HP:0002667)2.47910022
20Short middle phalanx of the 5th finger (HP:0004220)2.41074960
21Pancreatic cysts (HP:0001737)2.39608661
22Ectopic kidney (HP:0000086)2.39330922
23Chronic hepatic failure (HP:0100626)2.35500792
24True hermaphroditism (HP:0010459)2.31675703
25Sloping forehead (HP:0000340)2.28974110
26Asymmetry of the thorax (HP:0001555)2.28916466
27Metaphyseal dysplasia (HP:0100255)2.25893235
28Abnormality of the renal medulla (HP:0100957)2.25452475
29Long eyelashes (HP:0000527)2.25006392
30Oligodactyly (hands) (HP:0001180)2.24982515
31Embryonal renal neoplasm (HP:0011794)2.24507637
32Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.22779770
33Abnormality of cochlea (HP:0000375)2.21528222
34Lip pit (HP:0100267)2.21372841
35Short 4th metacarpal (HP:0010044)2.21135644
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21135644
37Hepatoblastoma (HP:0002884)2.19991833
38Anal stenosis (HP:0002025)2.18637172
39Supernumerary spleens (HP:0009799)2.17598499
40Abnormal hair whorl (HP:0010721)2.17491194
41Aplastic anemia (HP:0001915)2.15672932
42Abnormality of chromosome stability (HP:0003220)2.15583319
43Abnormality of the nasal septum (HP:0000419)2.13438051
44Patellar aplasia (HP:0006443)2.12500235
45Broad-based gait (HP:0002136)2.11972801
46Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.11561369
47Gait imbalance (HP:0002141)2.10076659
48Myelodysplasia (HP:0002863)2.09793501
49Poor coordination (HP:0002370)2.09137047
50Meckel diverticulum (HP:0002245)2.08896092
51Congenital primary aphakia (HP:0007707)2.08706887
52Abnormality of the incisor (HP:0000676)2.07077123
53Morphological abnormality of the inner ear (HP:0011390)2.06264678
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.05779393
55Asplenia (HP:0001746)2.05770771
56Deep philtrum (HP:0002002)2.05262592
57Stenosis of the external auditory canal (HP:0000402)2.03795512
58Triphalangeal thumb (HP:0001199)2.03630899
59Narrow forehead (HP:0000341)2.02671090
60Abnormality of the ileum (HP:0001549)2.02551938
61Limb hypertonia (HP:0002509)2.02290223
62Abnormality of the preputium (HP:0100587)2.02118659
63Abnormality of the columella (HP:0009929)2.01612483
64Acute myeloid leukemia (HP:0004808)2.01572719
65Drooling (HP:0002307)2.01217652
66Protruding tongue (HP:0010808)2.01164588
67Macrocytic anemia (HP:0001972)2.00430021
68Aplasia/Hypoplasia of the patella (HP:0006498)1.98817096
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.97439193
70Duplicated collecting system (HP:0000081)1.97399809
71Intestinal atresia (HP:0011100)1.97102481
72Increased nuchal translucency (HP:0010880)1.96599731
73Abnormal number of erythroid precursors (HP:0012131)1.94337586
74Nephrogenic diabetes insipidus (HP:0009806)1.93180521
75Trigonocephaly (HP:0000243)1.90342809
76Abnormality of cells of the erythroid lineage (HP:0012130)1.88296702
77Narrow palate (HP:0000189)1.88231626
78Genital tract atresia (HP:0001827)1.88009745
79Postaxial foot polydactyly (HP:0001830)1.87513904
80Hyperventilation (HP:0002883)1.86938925
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.85013166
82Optic nerve coloboma (HP:0000588)1.84623966
83Vaginal atresia (HP:0000148)1.83783453
84Abnormality of DNA repair (HP:0003254)1.83097057
85Clubbing of toes (HP:0100760)1.81692805
86Excessive salivation (HP:0003781)1.80758498
87Tented upper lip vermilion (HP:0010804)1.79298996
88Neoplasm of the adrenal cortex (HP:0100641)1.78022394
89Postaxial hand polydactyly (HP:0001162)1.77437430
90Proximal placement of thumb (HP:0009623)1.77326812
91Panhypogammaglobulinemia (HP:0003139)1.76751495
92Abnormality of the frontal sinuses (HP:0002687)1.76683079
93Vertebral arch anomaly (HP:0008438)1.76119120
94Microtia (HP:0008551)1.74895449
9511 pairs of ribs (HP:0000878)1.74887407
96Impulsivity (HP:0100710)1.74657829
97Tubulointerstitial nephritis (HP:0001970)1.74129989
98Duodenal stenosis (HP:0100867)1.73203461
99Small intestinal stenosis (HP:0012848)1.73203461
100Aqueductal stenosis (HP:0002410)1.72799372
101Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72695405
102Pallor (HP:0000980)1.70794054
103Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70320054
104Short 1st metacarpal (HP:0010034)1.70320054
105Rib fusion (HP:0000902)1.70276272
106Abnormal biliary tract physiology (HP:0012439)1.69765097
107Bile duct proliferation (HP:0001408)1.69765097
108Fibular hypoplasia (HP:0003038)1.69660746
109Broad palm (HP:0001169)1.68648867
110Gastrointestinal atresia (HP:0002589)1.68320671
111Cupped ear (HP:0000378)1.67963582
112Dandy-Walker malformation (HP:0001305)1.67937788
113Diastasis recti (HP:0001540)1.67909658
114Molar tooth sign on MRI (HP:0002419)1.67807949
115Abnormality of midbrain morphology (HP:0002418)1.67807949
116Reticulocytopenia (HP:0001896)1.67239172
117Anophthalmia (HP:0000528)1.66231466
118Multicystic kidney dysplasia (HP:0000003)1.66220089
119Abnormality of the renal cortex (HP:0011035)1.65964113
120IgM deficiency (HP:0002850)1.64922608
121Astigmatism (HP:0000483)1.64904770
122Highly arched eyebrow (HP:0002553)1.64400526
123Increased number of teeth (HP:0011069)1.64263220
124Abnormality of the carotid arteries (HP:0005344)1.64063814
125Cystic liver disease (HP:0006706)1.63612052
126B lymphocytopenia (HP:0010976)1.62981070
127Abnormality of B cell number (HP:0010975)1.62981070
128Abnormality of homocysteine metabolism (HP:0010919)1.62839784
129Homocystinuria (HP:0002156)1.62839784
130Prominent nasal bridge (HP:0000426)1.62817793
131Absent/shortened dynein arms (HP:0200106)1.62622152
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.62622152
133Abnormality of the phalanges of the 2nd finger (HP:0009541)1.62000986
134Deviation of the thumb (HP:0009603)1.61083543
135Long clavicles (HP:0000890)1.61048018
136Congenital stationary night blindness (HP:0007642)1.60724402
137Abnormality of the pons (HP:0007361)1.60631196
138Preaxial hand polydactyly (HP:0001177)1.60468488
139Papillary thyroid carcinoma (HP:0002895)1.60283851
140Abnormal lung lobation (HP:0002101)1.59952829
141Oligodactyly (HP:0012165)1.59533308
142Agammaglobulinemia (HP:0004432)1.58214042
143Prominent nose (HP:0000448)1.58103616
144Facial hemangioma (HP:0000329)1.58053206
145Colon cancer (HP:0003003)1.57238802
146Hypoplasia of the maxilla (HP:0000327)1.57051078
147Obsessive-compulsive behavior (HP:0000722)1.56350805
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.56183922
149Abnormality of the duodenum (HP:0002246)1.55622913
150Abnormality of the renal collecting system (HP:0004742)1.54607038
151Mesomelia (HP:0003027)1.54294220
152Limited elbow extension (HP:0001377)1.52448092
153Urethral obstruction (HP:0000796)1.51882479
154Ependymoma (HP:0002888)1.51385127
155Aplasia cutis congenita (HP:0001057)1.51213012
156Septo-optic dysplasia (HP:0100842)1.50411968
157Agnosia (HP:0010524)1.50359526
158Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.48539757
159Esophageal atresia (HP:0002032)1.47697422
160T lymphocytopenia (HP:0005403)1.47141311
161Premature graying of hair (HP:0002216)1.46236720
162Neoplasm of the oral cavity (HP:0100649)1.45888477
163Short thumb (HP:0009778)1.45415214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK14.14722965
2BCKDK4.10579190
3CDC73.74573445
4MKNK23.57555423
5BRD43.15239121
6TNIK2.92502816
7SRPK12.86109727
8CDK122.71826992
9MAP3K42.39284824
10SIK22.24761611
11BUB12.16659559
12WNK32.08980329
13CLK12.07693368
14FRK2.06100985
15NUAK11.87887575
16IRAK41.86049123
17NEK21.79448090
18ATR1.79121883
19CDK71.59102794
20TAF11.57218814
21SIK31.56292319
22CASK1.54601602
23WEE11.43495806
24MAP4K11.42107485
25TEC1.38252212
26RPS6KA41.31818517
27CAMK1G1.31473453
28STK161.27499872
29PNCK1.24670698
30MAP4K21.24156887
31MAP3K141.20051812
32ERBB31.19723667
33YES11.18066232
34JAK31.16940199
35BTK1.16537036
36CHEK11.16427493
37DYRK1A1.15427706
38FES1.14448998
39ATM1.11527833
40NEK61.11298568
41TYRO31.09927153
42AKT31.09767065
43NTRK21.08503316
44NLK1.08371440
45TTK1.07078477
46TGFBR10.99624874
47LATS10.99343532
48CDK90.99138984
49NTRK30.98767647
50CAMK1D0.98112836
51CHEK20.95403757
52TXK0.95105105
53PASK0.94580875
54CDK40.93727923
55DYRK20.93027768
56VRK10.92315601
57DMPK0.92046420
58* CDK20.90229422
59AURKB0.90217165
60TAOK30.90131409
61BRSK20.88412286
62CDK30.85714578
63RIPK40.85285381
64PLK30.84255339
65TLK10.82361043
66EIF2AK30.82238288
67CHUK0.81871727
68KIT0.81764744
69TNK20.81684159
70BLK0.81466369
71ZAK0.81387182
72WNK40.79550782
73CDK10.78259801
74STK30.75869971
75MAPK140.75311134
76EIF2AK20.75279162
77STK390.74945931
78MAP2K70.74375300
79PLK10.71643850
80MAP3K130.71118071
81GRK10.70756004
82CDK60.70639142
83HIPK20.70215769
84CDC42BPA0.69751134
85MARK10.68986541
86PRKDC0.68602877
87FGFR10.66267045
88STK110.66226621
89CSNK1E0.64523407
90CDK190.63829128
91CDK80.63468170
92CCNB10.63407970
93LCK0.62609573
94ACVR1B0.62385414
95GSK3B0.62182143
96LYN0.60676153
97ITK0.59990616
98STK40.59649149
99SGK20.59523358
100CSNK1A1L0.58506479
101PINK10.58057900
102OXSR10.57245348
103BCR0.55827579
104RPS6KA50.55015445
105SGK10.54506934
106WNK10.54021095
107PAK30.53948742
108STK38L0.53558086
109RPS6KB20.52919558
110MAPK130.52511531
111AKT10.52225941
112PRKCG0.52144598
113MARK20.51580946
114IRAK30.51429489
115MAP3K100.50385048
116SYK0.49028534
117FGFR30.48346102
118CSNK2A20.48226199
119UHMK10.47317022
120CSNK1D0.46956388
121MAPK150.46673132
122MAPK100.46626054
123IKBKE0.45732896
124CSF1R0.44979449
125BRSK10.44502012
126RPS6KB10.44335871
127PLK40.44217677
128FLT30.44203383
129MAP3K80.44128284
130BMPR1B0.42801544
131MARK30.42151134
132FGFR20.42127940
133HCK0.42090268
134TRIM280.41676117
135PRKCH0.41301122
136MELK0.41219937
137MAPK80.40426358
138DYRK30.40071793
139SGK4940.39759328
140SGK2230.39759328
141CSNK1G10.39485657
142MINK10.34638587
143PIK3CA0.34241165
144EPHA40.33670570
145NME10.31058501

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.73868555
2Mismatch repair_Homo sapiens_hsa034302.72358642
3Spliceosome_Homo sapiens_hsa030402.71521931
4Homologous recombination_Homo sapiens_hsa034402.39494445
5Fanconi anemia pathway_Homo sapiens_hsa034602.34157640
6Propanoate metabolism_Homo sapiens_hsa006402.19247979
7Protein export_Homo sapiens_hsa030602.11302030
8mRNA surveillance pathway_Homo sapiens_hsa030151.98307260
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81336445
10Base excision repair_Homo sapiens_hsa034101.77174217
11Cell cycle_Homo sapiens_hsa041101.75856885
12Non-homologous end-joining_Homo sapiens_hsa034501.71062124
13RNA transport_Homo sapiens_hsa030131.69575119
14RNA degradation_Homo sapiens_hsa030181.59525835
15Nucleotide excision repair_Homo sapiens_hsa034201.54410598
16Phototransduction_Homo sapiens_hsa047441.50900646
17Primary immunodeficiency_Homo sapiens_hsa053401.49975883
18Ribosome_Homo sapiens_hsa030101.35631693
19Selenocompound metabolism_Homo sapiens_hsa004501.34034551
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31099381
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29566878
22Herpes simplex infection_Homo sapiens_hsa051681.29220738
23Basal transcription factors_Homo sapiens_hsa030221.21656021
24RNA polymerase_Homo sapiens_hsa030201.17284523
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11729107
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08733932
27B cell receptor signaling pathway_Homo sapiens_hsa046621.06914387
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.06474593
29Notch signaling pathway_Homo sapiens_hsa043301.06379354
30MicroRNAs in cancer_Homo sapiens_hsa052061.06054377
31One carbon pool by folate_Homo sapiens_hsa006701.03842347
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03371295
33Linoleic acid metabolism_Homo sapiens_hsa005911.02931503
34Basal cell carcinoma_Homo sapiens_hsa052171.02037264
35p53 signaling pathway_Homo sapiens_hsa041151.01063781
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.00398447
37Wnt signaling pathway_Homo sapiens_hsa043101.00294823
38Measles_Homo sapiens_hsa051620.98589376
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98277164
40Sulfur relay system_Homo sapiens_hsa041220.97582849
41T cell receptor signaling pathway_Homo sapiens_hsa046600.97274617
42Ether lipid metabolism_Homo sapiens_hsa005650.97222684
43HTLV-I infection_Homo sapiens_hsa051660.94884173
44Nicotine addiction_Homo sapiens_hsa050330.93462220
45Lysine degradation_Homo sapiens_hsa003100.91885547
46Olfactory transduction_Homo sapiens_hsa047400.91043440
47Antigen processing and presentation_Homo sapiens_hsa046120.87624321
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86674813
49Long-term potentiation_Homo sapiens_hsa047200.84225048
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83060652
51Pyrimidine metabolism_Homo sapiens_hsa002400.83055692
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82552916
53Hematopoietic cell lineage_Homo sapiens_hsa046400.82012628
54Small cell lung cancer_Homo sapiens_hsa052220.80970032
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79632389
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78823781
57Nitrogen metabolism_Homo sapiens_hsa009100.78236489
58Chronic myeloid leukemia_Homo sapiens_hsa052200.78112227
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77276412
60Epstein-Barr virus infection_Homo sapiens_hsa051690.77246320
61Oocyte meiosis_Homo sapiens_hsa041140.76170010
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75874024
63Prostate cancer_Homo sapiens_hsa052150.75844646
64Platelet activation_Homo sapiens_hsa046110.75623836
65Acute myeloid leukemia_Homo sapiens_hsa052210.75614423
66Circadian rhythm_Homo sapiens_hsa047100.74847761
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71449247
68Cocaine addiction_Homo sapiens_hsa050300.71314936
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70482322
70Regulation of autophagy_Homo sapiens_hsa041400.70239987
71Thyroid cancer_Homo sapiens_hsa052160.69469985
72Pathways in cancer_Homo sapiens_hsa052000.69010263
73Adherens junction_Homo sapiens_hsa045200.68905650
74Hepatitis B_Homo sapiens_hsa051610.68276437
75Long-term depression_Homo sapiens_hsa047300.67021093
76Colorectal cancer_Homo sapiens_hsa052100.65607008
77Dopaminergic synapse_Homo sapiens_hsa047280.65302514
78Glutamatergic synapse_Homo sapiens_hsa047240.65267435
79Huntingtons disease_Homo sapiens_hsa050160.65195004
80Morphine addiction_Homo sapiens_hsa050320.65119936
81Circadian entrainment_Homo sapiens_hsa047130.64262809
82Viral carcinogenesis_Homo sapiens_hsa052030.64246651
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64100191
84Osteoclast differentiation_Homo sapiens_hsa043800.63419540
85Butanoate metabolism_Homo sapiens_hsa006500.62884049
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62384174
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61851689
88Influenza A_Homo sapiens_hsa051640.61461960
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61364100
90Steroid biosynthesis_Homo sapiens_hsa001000.61248304
91Insulin secretion_Homo sapiens_hsa049110.61022587
92Choline metabolism in cancer_Homo sapiens_hsa052310.60437728
93Chemokine signaling pathway_Homo sapiens_hsa040620.60282911
94Parkinsons disease_Homo sapiens_hsa050120.59864967
95Axon guidance_Homo sapiens_hsa043600.59508158
96Leishmaniasis_Homo sapiens_hsa051400.59325255
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59226913
98Hedgehog signaling pathway_Homo sapiens_hsa043400.59002001
99MAPK signaling pathway_Homo sapiens_hsa040100.58269518
100Hippo signaling pathway_Homo sapiens_hsa043900.58216760
101Melanogenesis_Homo sapiens_hsa049160.57777815
102Non-small cell lung cancer_Homo sapiens_hsa052230.57508324
103TGF-beta signaling pathway_Homo sapiens_hsa043500.57275568
104Folate biosynthesis_Homo sapiens_hsa007900.57216659
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56429397
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56095255
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55252310
108Calcium signaling pathway_Homo sapiens_hsa040200.54873946
109Purine metabolism_Homo sapiens_hsa002300.54471877
110cAMP signaling pathway_Homo sapiens_hsa040240.53847958
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.53657936
112Shigellosis_Homo sapiens_hsa051310.52625517
113Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52275090
114Taste transduction_Homo sapiens_hsa047420.52234003
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.52002171
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.51591733
117Oxytocin signaling pathway_Homo sapiens_hsa049210.51584474
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50789679
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50397076
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.49987826
121Amphetamine addiction_Homo sapiens_hsa050310.49495244
122Dorso-ventral axis formation_Homo sapiens_hsa043200.48796071
123Serotonergic synapse_Homo sapiens_hsa047260.48306613
124Oxidative phosphorylation_Homo sapiens_hsa001900.48250776
125TNF signaling pathway_Homo sapiens_hsa046680.48129021
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47538425
127Alcoholism_Homo sapiens_hsa050340.47397546
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46764461
129Proteoglycans in cancer_Homo sapiens_hsa052050.46672490
130Pancreatic cancer_Homo sapiens_hsa052120.46652698
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.46592534
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42885617
133Retinol metabolism_Homo sapiens_hsa008300.41509140
134Cardiac muscle contraction_Homo sapiens_hsa042600.41156596
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.36923917
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35147013
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34446954
138GABAergic synapse_Homo sapiens_hsa047270.33538921
139FoxO signaling pathway_Homo sapiens_hsa040680.32672818
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32480545
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30400178
142Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28390660
143Ras signaling pathway_Homo sapiens_hsa040140.24998980
144Vitamin digestion and absorption_Homo sapiens_hsa049770.24606521
145Cholinergic synapse_Homo sapiens_hsa047250.23870391

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