SRSF12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.55943463
2vocalization behavior (GO:0071625)5.53572566
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31871315
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.12893644
5synaptic vesicle exocytosis (GO:0016079)5.10399752
6protein localization to synapse (GO:0035418)4.91803236
7presynaptic membrane assembly (GO:0097105)4.81539097
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.74680378
9presynaptic membrane organization (GO:0097090)4.66307691
10regulation of glutamate receptor signaling pathway (GO:1900449)4.65171179
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.52139580
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34574411
13synaptic vesicle maturation (GO:0016188)4.31648891
14regulation of synaptic vesicle exocytosis (GO:2000300)4.24706944
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22210352
16exploration behavior (GO:0035640)4.18222634
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.17920701
18locomotory exploration behavior (GO:0035641)4.14758812
19synaptic transmission, glutamatergic (GO:0035249)4.14204933
20neurotransmitter secretion (GO:0007269)4.13278804
21glutamate secretion (GO:0014047)4.11644570
22glutamate receptor signaling pathway (GO:0007215)4.11046204
23neurotransmitter-gated ion channel clustering (GO:0072578)4.10963212
24postsynaptic membrane organization (GO:0001941)4.10460582
25neuron recognition (GO:0008038)4.05794603
26neuron-neuron synaptic transmission (GO:0007270)4.03789093
27behavioral response to nicotine (GO:0035095)4.01364189
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.93079501
29nucleobase catabolic process (GO:0046113)3.79120423
30regulation of synaptic vesicle transport (GO:1902803)3.78613997
31negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.77991425
32positive regulation of synaptic transmission, GABAergic (GO:0032230)3.77303766
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.76767800
34positive regulation of synapse assembly (GO:0051965)3.75832290
35DNA double-strand break processing (GO:0000729)3.75634447
36startle response (GO:0001964)3.74806739
37piRNA metabolic process (GO:0034587)3.73418024
38neuronal action potential propagation (GO:0019227)3.70946095
39dendritic spine morphogenesis (GO:0060997)3.67876332
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66055162
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.64057879
42axonal fasciculation (GO:0007413)3.61253992
43auditory behavior (GO:0031223)3.59898944
44nonmotile primary cilium assembly (GO:0035058)3.58136277
45proline transport (GO:0015824)3.56880555
46regulation of neuronal synaptic plasticity (GO:0048168)3.55229877
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.52116825
48transmission of nerve impulse (GO:0019226)3.50589705
49layer formation in cerebral cortex (GO:0021819)3.49187224
50gamma-aminobutyric acid transport (GO:0015812)3.44725146
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44676326
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.42977657
53regulation of synaptic transmission, GABAergic (GO:0032228)3.40495646
54response to histamine (GO:0034776)3.39578761
55neurotransmitter transport (GO:0006836)3.39181095
56mechanosensory behavior (GO:0007638)3.37687112
57pyrimidine nucleobase catabolic process (GO:0006208)3.37442293
58regulation of synapse structural plasticity (GO:0051823)3.36058644
59synapse assembly (GO:0007416)3.34064242
60regulation of postsynaptic membrane potential (GO:0060078)3.33764625
61cell migration in hindbrain (GO:0021535)3.33668256
62response to auditory stimulus (GO:0010996)3.33067300
63long-term memory (GO:0007616)3.32798836
64membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.29582866
65cerebral cortex radially oriented cell migration (GO:0021799)3.26935493
66positive regulation of membrane potential (GO:0045838)3.25662219
67synaptic vesicle endocytosis (GO:0048488)3.24552761
68long-term synaptic potentiation (GO:0060291)3.24340224
69neuron fate determination (GO:0048664)3.19390190
70regulation of glutamate secretion (GO:0014048)3.18969635
71regulation of meiosis I (GO:0060631)3.18581088
72righting reflex (GO:0060013)3.15551434
73membrane hyperpolarization (GO:0060081)3.14842010
74behavioral fear response (GO:0001662)3.14681238
75behavioral defense response (GO:0002209)3.14681238
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14219351
77regulation of neurotransmitter levels (GO:0001505)3.13948927
78intraciliary transport (GO:0042073)3.12423743
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.12317761
80positive regulation of synapse maturation (GO:0090129)3.11966385
81learning (GO:0007612)3.10502911
82retinal ganglion cell axon guidance (GO:0031290)3.08977699
83protein polyglutamylation (GO:0018095)3.08354030
84epithelial cilium movement (GO:0003351)3.08144349
85negative regulation of transcription regulatory region DNA binding (GO:2000678)3.07579624
86regulation of synapse assembly (GO:0051963)3.07321202
87regulation of cilium movement (GO:0003352)3.07272739
88central nervous system projection neuron axonogenesis (GO:0021952)3.06401660
89behavioral response to cocaine (GO:0048148)3.06080631
90regulation of respiratory system process (GO:0044065)3.05680059
91response to pheromone (GO:0019236)3.05412980
92striatum development (GO:0021756)3.05393793
93dendrite development (GO:0016358)3.03388719
94regulation of neurotransmitter secretion (GO:0046928)3.03224714
95establishment of mitochondrion localization (GO:0051654)2.99953230
96regulation of cAMP-dependent protein kinase activity (GO:2000479)2.99607211
97cerebellar granule cell differentiation (GO:0021707)2.97565793
98regulation of vesicle fusion (GO:0031338)2.96626340
99dendrite morphogenesis (GO:0048813)2.96381057
100negative regulation of microtubule polymerization (GO:0031115)2.95408018
101regulation of synaptic plasticity (GO:0048167)2.95008452
102membrane depolarization (GO:0051899)2.94918176
103prepulse inhibition (GO:0060134)2.91426149
104activation of protein kinase A activity (GO:0034199)2.90598611
105somite development (GO:0061053)2.90338904
106cerebellar Purkinje cell differentiation (GO:0021702)2.89535732
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89197488
108regulation of dendritic spine morphogenesis (GO:0061001)2.88995133
109fear response (GO:0042596)2.88865439
110synapse organization (GO:0050808)2.87994802
111neuronal ion channel clustering (GO:0045161)2.85799507
112synaptic transmission (GO:0007268)2.85606495
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84760301
114establishment of synaptic vesicle localization (GO:0097480)2.84203971
115cilium morphogenesis (GO:0060271)2.83656219
116synapsis (GO:0007129)2.80251493
117limb bud formation (GO:0060174)2.78947848
118DNA methylation involved in gamete generation (GO:0043046)2.78759986
119cilium organization (GO:0044782)2.75906946
120neural tube formation (GO:0001841)2.74817406
121protein K11-linked deubiquitination (GO:0035871)2.74204286
122cilium assembly (GO:0042384)2.73970185
123hindbrain development (GO:0030902)2.72914722
124detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67636780
125glycerophospholipid catabolic process (GO:0046475)2.67396575
126epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.67217026
127somite rostral/caudal axis specification (GO:0032525)2.64723078
128establishment of protein localization to mitochondrial membrane (GO:0090151)2.61682603
129protein-cofactor linkage (GO:0018065)2.61663685
130cell proliferation in forebrain (GO:0021846)2.61180763
131positive regulation of mitochondrial fission (GO:0090141)2.60162565
132forebrain neuron differentiation (GO:0021879)2.60136774
133mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50628192
134mitochondrial respiratory chain complex I assembly (GO:0032981)2.50628192
135NADH dehydrogenase complex assembly (GO:0010257)2.50628192
136olfactory bulb development (GO:0021772)2.50038231
137resolution of meiotic recombination intermediates (GO:0000712)2.49425530
138C4-dicarboxylate transport (GO:0015740)2.48455286
139positive regulation of oligodendrocyte differentiation (GO:0048714)2.48013477
140regulation of development, heterochronic (GO:0040034)2.46366705
141protein complex biogenesis (GO:0070271)2.46231730
142positive regulation of meiosis (GO:0045836)2.45893348
143water-soluble vitamin biosynthetic process (GO:0042364)2.45684503
144protein localization to cilium (GO:0061512)2.45327507
145negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44429239
146axoneme assembly (GO:0035082)2.44419369
147protein neddylation (GO:0045116)2.42548579
148centriole replication (GO:0007099)2.42241289
149cilium movement (GO:0003341)2.41514095
150photoreceptor cell development (GO:0042461)2.41479794
151neurofilament cytoskeleton organization (GO:0060052)2.41079024
152inner ear receptor stereocilium organization (GO:0060122)2.40893411
153calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.37691934
154platelet dense granule organization (GO:0060155)2.37681994
155smoothened signaling pathway (GO:0007224)2.37415568
156chromatin remodeling at centromere (GO:0031055)2.37013355
157regulation of timing of cell differentiation (GO:0048505)2.35650278
158regulation of microtubule-based movement (GO:0060632)2.35634587
159fucose catabolic process (GO:0019317)2.34928878
160L-fucose metabolic process (GO:0042354)2.34928878
161L-fucose catabolic process (GO:0042355)2.34928878
162acrosome reaction (GO:0007340)2.34089195
163glycosphingolipid biosynthetic process (GO:0006688)2.29551945
164DNA replication checkpoint (GO:0000076)2.27982545
165behavioral response to ethanol (GO:0048149)2.27166642
166positive regulation of gastrulation (GO:2000543)2.27137692
167positive regulation of meiotic cell cycle (GO:0051446)2.27056340
168positive regulation of amino acid transport (GO:0051957)2.26124911
169otic vesicle formation (GO:0030916)2.25293778
170reciprocal DNA recombination (GO:0035825)2.24342958
171reciprocal meiotic recombination (GO:0007131)2.24342958
172indole-containing compound catabolic process (GO:0042436)2.24135646
173indolalkylamine catabolic process (GO:0046218)2.24135646
174tryptophan catabolic process (GO:0006569)2.24135646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58879302
2GBX2_23144817_ChIP-Seq_PC3_Human4.06959804
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05418853
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92127169
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88992155
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79824610
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.63811717
8TAF15_26573619_Chip-Seq_HEK293_Human2.51216368
9REST_21632747_ChIP-Seq_MESCs_Mouse2.49878321
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44534018
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43620149
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43620149
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43183276
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39098193
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31197845
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.31172053
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27929218
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26592007
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26413324
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.23765863
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20548907
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.19190582
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16806154
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13338542
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.10878091
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08240025
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.05466984
28AR_21572438_ChIP-Seq_LNCaP_Human2.04631952
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01855792
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93212625
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.91611384
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91409743
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88331800
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.86124452
35P300_19829295_ChIP-Seq_ESCs_Human1.85118701
36VDR_22108803_ChIP-Seq_LS180_Human1.84789506
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83830496
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82440919
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81315765
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80414353
41SMAD4_21799915_ChIP-Seq_A2780_Human1.76899359
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.73389835
43RNF2_27304074_Chip-Seq_NSC_Mouse1.72769747
44DROSHA_22980978_ChIP-Seq_HELA_Human1.72734589
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72701132
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72425826
47FUS_26573619_Chip-Seq_HEK293_Human1.65044125
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61262171
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58563599
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52566250
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52561614
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51992799
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.51871676
54IRF1_19129219_ChIP-ChIP_H3396_Human1.50808140
55IGF1R_20145208_ChIP-Seq_DFB_Human1.50768228
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49540100
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47200572
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46721690
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42869356
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.42527594
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42288261
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.40257588
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.38995490
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37509243
65AR_25329375_ChIP-Seq_VCAP_Human1.37324139
66MYC_18940864_ChIP-ChIP_HL60_Human1.36653502
67ER_23166858_ChIP-Seq_MCF-7_Human1.35110283
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33634971
69CBP_20019798_ChIP-Seq_JUKART_Human1.33634971
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.32885592
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.30827319
72ZNF274_21170338_ChIP-Seq_K562_Hela1.30524855
73STAT3_23295773_ChIP-Seq_U87_Human1.29795966
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28782579
75TP53_22573176_ChIP-Seq_HFKS_Human1.28603924
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28213460
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.27069635
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26927823
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25861586
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25516050
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23917308
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23751264
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23551209
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23458026
85BCAT_22108803_ChIP-Seq_LS180_Human1.22142786
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21785216
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21785216
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21035066
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20656248
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.20154198
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18965338
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.18516691
93TCF4_23295773_ChIP-Seq_U87_Human1.17317257
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.16957194
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15579975
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13373779
97RUNX2_22187159_ChIP-Seq_PCA_Human1.12025492
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11151084
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.11099544
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.10336310
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.10241713
102AR_19668381_ChIP-Seq_PC3_Human1.09283466
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.07930397
104JUN_21703547_ChIP-Seq_K562_Human1.07752210
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07535447
106YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07448963
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.07004335
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.06807309
109CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06360466
110AHR_22903824_ChIP-Seq_MCF-7_Human1.05930490
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05805673
112TCF4_22108803_ChIP-Seq_LS180_Human1.05342555
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05166576
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.04378856
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04263015
116TP63_19390658_ChIP-ChIP_HaCaT_Human1.04137645
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03503801
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.03316609
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03213278
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03011805
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01233558
122ELK1_19687146_ChIP-ChIP_HELA_Human1.00655097
123SOX2_19829295_ChIP-Seq_ESCs_Human0.99929038
124NANOG_19829295_ChIP-Seq_ESCs_Human0.99929038
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99382908
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.99317999
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.99089949
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98847406
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.97378138
130TP53_18474530_ChIP-ChIP_U2OS_Human0.96648072
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96231797
132KDM2B_26808549_Chip-Seq_REH_Human0.95489220
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94784611
134EWS_26573619_Chip-Seq_HEK293_Human0.94707897
135P53_22387025_ChIP-Seq_ESCs_Mouse0.93500202
136EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92617985
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.91780477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08462239
2MP0003880_abnormal_central_pattern4.40272623
3MP0003635_abnormal_synaptic_transmissio3.80472296
4MP0004270_analgesia3.21274023
5MP0009745_abnormal_behavioral_response3.20701145
6MP0002063_abnormal_learning/memory/cond3.16964311
7MP0001968_abnormal_touch/_nociception3.02541916
8MP0005423_abnormal_somatic_nervous2.98324447
9MP0002064_seizures2.95028303
10MP0002572_abnormal_emotion/affect_behav2.91459176
11MP0006276_abnormal_autonomic_nervous2.83700398
12MP0008877_abnormal_DNA_methylation2.80141826
13MP0009046_muscle_twitch2.76642892
14MP0002734_abnormal_mechanical_nocicepti2.63768480
15MP0001486_abnormal_startle_reflex2.63209740
16MP0002736_abnormal_nociception_after2.58715851
17MP0002735_abnormal_chemical_nociception2.51646175
18MP0003122_maternal_imprinting2.49586238
19MP0002272_abnormal_nervous_system2.48302508
20MP0001529_abnormal_vocalization2.42437604
21MP0002822_catalepsy2.32011919
22MP0003136_yellow_coat_color2.28623458
23MP0003787_abnormal_imprinting2.28542630
24MP0000778_abnormal_nervous_system2.25783249
25MP0001501_abnormal_sleep_pattern2.13363346
26MP0002733_abnormal_thermal_nociception2.11655290
27MP0005645_abnormal_hypothalamus_physiol2.04847584
28MP0002067_abnormal_sensory_capabilities2.02251289
29MP0001188_hyperpigmentation2.01817259
30MP0001984_abnormal_olfaction1.99952842
31MP0001440_abnormal_grooming_behavior1.98215482
32MP0002184_abnormal_innervation1.97875876
33MP0002557_abnormal_social/conspecific_i1.96608348
34MP0002653_abnormal_ependyma_morphology1.96003469
35MP0002234_abnormal_pharynx_morphology1.94392834
36MP0001970_abnormal_pain_threshold1.94101999
37MP0005646_abnormal_pituitary_gland1.89639304
38MP0004924_abnormal_behavior1.89533575
39MP0005386_behavior/neurological_phenoty1.89533575
40MP0001905_abnormal_dopamine_level1.82903929
41MP0004811_abnormal_neuron_physiology1.67144490
42MP0002938_white_spotting1.65767191
43MP0008569_lethality_at_weaning1.58538986
44MP0005409_darkened_coat_color1.56402304
45MP0000955_abnormal_spinal_cord1.49766324
46MP0004133_heterotaxia1.48473093
47MP0002882_abnormal_neuron_morphology1.44179284
48MP0001293_anophthalmia1.39749667
49MP0002066_abnormal_motor_capabilities/c1.38817957
50MP0003121_genomic_imprinting1.37753043
51MP0008058_abnormal_DNA_repair1.37695378
52MP0004142_abnormal_muscle_tone1.32657871
53MP0005187_abnormal_penis_morphology1.32132078
54MP0000049_abnormal_middle_ear1.30886982
55MP0002909_abnormal_adrenal_gland1.30388383
56MP0005084_abnormal_gallbladder_morpholo1.29749761
57MP0003329_amyloid_beta_deposits1.29074667
58MP0001502_abnormal_circadian_rhythm1.27720323
59MP0002152_abnormal_brain_morphology1.21026897
60MP0000631_abnormal_neuroendocrine_gland1.19496119
61MP0010386_abnormal_urinary_bladder1.18120815
62MP0004885_abnormal_endolymph1.17289817
63MP0001485_abnormal_pinna_reflex1.16045218
64MP0006292_abnormal_olfactory_placode1.15243648
65MP0004858_abnormal_nervous_system1.15238709
66MP0002233_abnormal_nose_morphology1.14116716
67MP0005174_abnormal_tail_pigmentation1.13081393
68MP0002210_abnormal_sex_determination1.11767467
69MP0005499_abnormal_olfactory_system1.11738789
70MP0005394_taste/olfaction_phenotype1.11738789
71MP0002163_abnormal_gland_morphology1.10603370
72MP0005195_abnormal_posterior_eye1.10202126
73MP0009780_abnormal_chondrocyte_physiolo1.09986687
74MP0005551_abnormal_eye_electrophysiolog1.08616025
75MP0003937_abnormal_limbs/digits/tail_de1.05876625
76MP0003119_abnormal_digestive_system1.04404687
77MP0004742_abnormal_vestibular_system1.03761939
78MP0000372_irregular_coat_pigmentation1.03562798
79MP0003698_abnormal_male_reproductive1.01497760
80MP0003718_maternal_effect1.01121401
81MP0001929_abnormal_gametogenesis1.00410131
82MP0002638_abnormal_pupillary_reflex0.99655649
83MP0003195_calcinosis0.99045166
84MP0003879_abnormal_hair_cell0.97862998
85MP0002160_abnormal_reproductive_system0.97483352
86MP0003633_abnormal_nervous_system0.96316155
87MP0005391_vision/eye_phenotype0.95524237
88MP0000647_abnormal_sebaceous_gland0.94138252
89MP0002069_abnormal_eating/drinking_beha0.93445205
90MP0000751_myopathy0.92024411
91MP0002752_abnormal_somatic_nervous0.91473175
92MP0002229_neurodegeneration0.90849882
93MP0003631_nervous_system_phenotype0.89519087
94MP0001963_abnormal_hearing_physiology0.88867135
95MP0001286_abnormal_eye_development0.88825765
96MP0000653_abnormal_sex_gland0.88218037
97MP0005379_endocrine/exocrine_gland_phen0.87205957
98MP0005389_reproductive_system_phenotype0.86946096
99MP0002928_abnormal_bile_duct0.86207826
100MP0000566_synostosis0.85697063
101MP0000427_abnormal_hair_cycle0.85441416
102MP0001145_abnormal_male_reproductive0.84673702
103MP0001177_atelectasis0.84640185
104MP0000569_abnormal_digit_pigmentation0.84552637
105MP0003567_abnormal_fetal_cardiomyocyte0.82966829
106MP0001986_abnormal_taste_sensitivity0.82068827
107MP0003634_abnormal_glial_cell0.81702702
108MP0002837_dystrophic_cardiac_calcinosis0.78656099
109MP0002876_abnormal_thyroid_physiology0.78193752
110MP0004085_abnormal_heartbeat0.77989366
111MP0003861_abnormal_nervous_system0.77804805
112MP0001299_abnormal_eye_distance/0.77366367
113MP0005535_abnormal_body_temperature0.72561273
114MP0002102_abnormal_ear_morphology0.72288717
115MP0005171_absent_coat_pigmentation0.71595936
116MP0000026_abnormal_inner_ear0.71395896
117MP0000015_abnormal_ear_pigmentation0.70666435
118MP0001943_abnormal_respiration0.70061570
119MP0008872_abnormal_physiological_respon0.68916088
120MP0003385_abnormal_body_wall0.67855745
121MP0003632_abnormal_nervous_system0.67351118
122MP0002751_abnormal_autonomic_nervous0.65064773
123MP0008789_abnormal_olfactory_epithelium0.62348902
124MP0003137_abnormal_impulse_conducting0.62306827
125MP0010770_preweaning_lethality0.62066174
126MP0002082_postnatal_lethality0.62066174
127MP0000920_abnormal_myelination0.60513815
128MP0010769_abnormal_survival0.60168572
129MP0001664_abnormal_digestion0.58723309
130MP0006072_abnormal_retinal_apoptosis0.58646085
131MP0010768_mortality/aging0.56956947
132MP0003938_abnormal_ear_development0.52464243
133MP0005253_abnormal_eye_physiology0.51362202
134MP0002081_perinatal_lethality0.50978372
135MP0000013_abnormal_adipose_tissue0.49674109
136MP0003890_abnormal_embryonic-extraembry0.47111236

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.57052823
2Myokymia (HP:0002411)5.63709691
3Focal seizures (HP:0007359)5.10120518
4Febrile seizures (HP:0002373)4.80413469
5Atonic seizures (HP:0010819)4.71960527
6Epileptic encephalopathy (HP:0200134)4.55440916
7Absence seizures (HP:0002121)4.05086996
8Progressive cerebellar ataxia (HP:0002073)4.00991113
9Visual hallucinations (HP:0002367)4.00717828
10Hyperventilation (HP:0002883)3.91920143
11True hermaphroditism (HP:0010459)3.73350292
12Limb dystonia (HP:0002451)3.66853863
13Dialeptic seizures (HP:0011146)3.64585818
14Pancreatic cysts (HP:0001737)3.57173507
15Generalized tonic-clonic seizures (HP:0002069)3.48230670
16Polyphagia (HP:0002591)3.48177844
17Pancreatic fibrosis (HP:0100732)3.46240818
18Broad-based gait (HP:0002136)3.45687537
19Ankle clonus (HP:0011448)3.44947248
20Abnormality of midbrain morphology (HP:0002418)3.40749925
21Molar tooth sign on MRI (HP:0002419)3.40749925
22Nephronophthisis (HP:0000090)3.32607633
23Progressive inability to walk (HP:0002505)3.23717484
24Abnormal hair whorl (HP:0010721)3.22540363
25Abnormality of the corticospinal tract (HP:0002492)3.22445000
26Truncal ataxia (HP:0002078)3.22380897
27Drooling (HP:0002307)3.18237795
28Excessive salivation (HP:0003781)3.18237795
29Impaired vibration sensation in the lower limbs (HP:0002166)2.95925374
30Mutism (HP:0002300)2.91412647
31Abnormal eating behavior (HP:0100738)2.85347823
32Poor eye contact (HP:0000817)2.82819281
33Termporal pattern (HP:0011008)2.80101596
34Insidious onset (HP:0003587)2.80101596
35Gait imbalance (HP:0002141)2.77000770
36Absent speech (HP:0001344)2.73634688
37Fetal akinesia sequence (HP:0001989)2.73071574
38Septo-optic dysplasia (HP:0100842)2.72726291
39Congenital stationary night blindness (HP:0007642)2.70604861
40Spastic gait (HP:0002064)2.70132950
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.67884434
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.67884434
43Inability to walk (HP:0002540)2.65937883
44Abnormality of the renal medulla (HP:0100957)2.65076136
45Failure to thrive in infancy (HP:0001531)2.63814063
46Type II lissencephaly (HP:0007260)2.60771673
47Optic nerve hypoplasia (HP:0000609)2.59859056
48Urinary bladder sphincter dysfunction (HP:0002839)2.59209582
49Anxiety (HP:0000739)2.56462927
50Gaze-evoked nystagmus (HP:0000640)2.56305709
51Amblyopia (HP:0000646)2.56028906
52Protruding tongue (HP:0010808)2.54364222
53Impaired social interactions (HP:0000735)2.52705734
54Abnormal social behavior (HP:0012433)2.52705734
55Action tremor (HP:0002345)2.50956303
56Supranuclear gaze palsy (HP:0000605)2.50516013
57Abnormality of binocular vision (HP:0011514)2.49671291
58Diplopia (HP:0000651)2.49671291
59Sclerocornea (HP:0000647)2.46488329
60Genetic anticipation (HP:0003743)2.45231503
61Sleep apnea (HP:0010535)2.44393475
62Epileptiform EEG discharges (HP:0011182)2.43394597
63Pheochromocytoma (HP:0002666)2.42204971
64Urinary urgency (HP:0000012)2.40554709
65Depression (HP:0000716)2.37771659
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.35691606
67Akinesia (HP:0002304)2.34568388
68EEG with generalized epileptiform discharges (HP:0011198)2.32915579
69Dysdiadochokinesis (HP:0002075)2.31959675
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.31258221
71Hyperglycinemia (HP:0002154)2.30214399
72Oligodactyly (hands) (HP:0001180)2.29841564
73Chronic hepatic failure (HP:0100626)2.28385009
74Dysmetria (HP:0001310)2.27986882
75Scanning speech (HP:0002168)2.27761603
76Medial flaring of the eyebrow (HP:0010747)2.26504514
77Anencephaly (HP:0002323)2.25121003
78Postaxial hand polydactyly (HP:0001162)2.23905072
79Postaxial foot polydactyly (HP:0001830)2.22148837
80Lower limb muscle weakness (HP:0007340)2.22053823
81Esotropia (HP:0000565)2.21745556
82Intestinal atresia (HP:0011100)2.21081607
83Abnormality of salivation (HP:0100755)2.20747244
84Abnormality of the labia minora (HP:0012880)2.20665905
85Narrow nasal bridge (HP:0000446)2.19649892
86Congenital primary aphakia (HP:0007707)2.19617833
87Specific learning disability (HP:0001328)2.18990061
88Agitation (HP:0000713)2.18540857
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.17616108
90Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17354301
91Hypoplasia of the brainstem (HP:0002365)2.17354301
92Neuroendocrine neoplasm (HP:0100634)2.17136124
93Hypsarrhythmia (HP:0002521)2.15522369
94Pachygyria (HP:0001302)2.14194371
95Nephrogenic diabetes insipidus (HP:0009806)2.14039354
96Neurofibrillary tangles (HP:0002185)2.11999087
97Cerebral inclusion bodies (HP:0100314)2.11551066
98Pendular nystagmus (HP:0012043)2.11339967
99Poor suck (HP:0002033)2.10677808
100Poor coordination (HP:0002370)2.10523734
101Short tibia (HP:0005736)2.09960369
102Amyotrophic lateral sclerosis (HP:0007354)2.09890301
103Blue irides (HP:0000635)2.08475824
104Preaxial hand polydactyly (HP:0001177)2.08039296
105Torticollis (HP:0000473)2.07563671
106Hemiparesis (HP:0001269)2.06210591
107Colon cancer (HP:0003003)2.05157560
108Hyperthyroidism (HP:0000836)2.04568986
109Cystic liver disease (HP:0006706)2.04293859
110Volvulus (HP:0002580)2.03279513
111Cerebellar dysplasia (HP:0007033)2.02421764
112Anophthalmia (HP:0000528)2.02168153
113Methylmalonic acidemia (HP:0002912)1.98170073
114Abnormality of the renal cortex (HP:0011035)1.97966750
115Male pseudohermaphroditism (HP:0000037)1.97863270
116Hypothermia (HP:0002045)1.95637885
117Morphological abnormality of the pyramidal tract (HP:0002062)1.93193637
118Occipital encephalocele (HP:0002085)1.92920272
119Narrow forehead (HP:0000341)1.92250160
120Focal dystonia (HP:0004373)1.91191287
121Inappropriate behavior (HP:0000719)1.90139536
122Exotropia (HP:0000577)1.90091282
123Generalized myoclonic seizures (HP:0002123)1.89482630
124Ectopic kidney (HP:0000086)1.85692852
125Acute necrotizing encephalopathy (HP:0006965)1.85650170
126Abolished electroretinogram (ERG) (HP:0000550)1.85336422
127Genital tract atresia (HP:0001827)1.84343847
128Bradykinesia (HP:0002067)1.83742535
129Stereotypic behavior (HP:0000733)1.83149687
130Broad foot (HP:0001769)1.83063759
131Vaginal atresia (HP:0000148)1.81586266
132Lissencephaly (HP:0001339)1.81441373
133Hypoventilation (HP:0002791)1.80994129
134Absent/shortened dynein arms (HP:0200106)1.80476503
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.80476503
136Neuronal loss in central nervous system (HP:0002529)1.78803975
137Retinal dysplasia (HP:0007973)1.78776718
138Abnormal rod and cone electroretinograms (HP:0008323)1.78531664
139Gastroesophageal reflux (HP:0002020)1.77192362
140Oligodactyly (HP:0012165)1.76822366
141Impaired vibratory sensation (HP:0002495)1.76237674
142Tubular atrophy (HP:0000092)1.76138550
143Congenital hepatic fibrosis (HP:0002612)1.75124252
144Incomplete penetrance (HP:0003829)1.74540673
145Renal hypoplasia (HP:0000089)1.73921381
146Mitochondrial inheritance (HP:0001427)1.73916046
147Astigmatism (HP:0000483)1.73328876
148Postural instability (HP:0002172)1.73203930
149Abnormality of macular pigmentation (HP:0008002)1.72795448
150Aganglionic megacolon (HP:0002251)1.72549330
151Absent septum pellucidum (HP:0001331)1.71723093
152Craniofacial dystonia (HP:0012179)1.71560995
153Supernumerary spleens (HP:0009799)1.71422113
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.71389343
155Gastrointestinal atresia (HP:0002589)1.70023745
156Progressive macrocephaly (HP:0004481)1.69455277
157Chorioretinal coloboma (HP:0000567)1.68976998
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.66805566
159Rib fusion (HP:0000902)1.66689828
160Decreased testicular size (HP:0008734)1.66115267
161Meckel diverticulum (HP:0002245)1.66044255
162Renal cortical cysts (HP:0000803)1.65480794
163Tubulointerstitial nephritis (HP:0001970)1.64988915
164Increased CSF lactate (HP:0002490)1.64459512
165Hyperglycinuria (HP:0003108)1.62462193
166Abnormality of the ileum (HP:0001549)1.62233235
167Thyroid-stimulating hormone excess (HP:0002925)1.62128638
168Attenuation of retinal blood vessels (HP:0007843)1.61744257
169Multicystic kidney dysplasia (HP:0000003)1.61697096
170Bony spicule pigmentary retinopathy (HP:0007737)1.61562398
171Acute encephalopathy (HP:0006846)1.60413916
172Dandy-Walker malformation (HP:0001305)1.59827207
173Retinitis pigmentosa (HP:0000510)1.59735140
174Abnormal biliary tract physiology (HP:0012439)1.59292506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.32560289
2CASK4.13142101
3NTRK33.70329470
4MAP2K73.51625300
5FRK3.49284114
6MAP3K43.44670569
7EPHA43.00519760
8MINK12.65463743
9MAP3K122.52256905
10MAP4K22.44716449
11NTRK22.36562690
12MAP3K92.25687036
13MAPK132.22479391
14ZAK2.04779775
15MAP2K42.00709370
16PNCK1.87542197
17TNIK1.80163699
18PINK11.78244517
19TRIM281.72972021
20PLK21.72653263
21TLK11.70785691
22NUAK11.63382170
23ERBB31.60568280
24SIK31.60242517
25PAK61.54826049
26WNK31.51566510
27MKNK21.48719508
28KSR11.48142202
29DAPK21.44094695
30SIK21.42479289
31PRPF4B1.42213076
32GRK51.34271519
33CDK51.33985949
34GRK11.32699143
35UHMK11.27192859
36BCR1.20607774
37PHKG11.18688003
38PHKG21.18688003
39CAMK2A1.17923644
40WEE11.17301719
41ACVR1B1.16792636
42PRKCG1.16457145
43SGK4941.16082980
44SGK2231.16082980
45CSNK1A1L1.16006190
46DAPK11.12892254
47CDK191.11018209
48STK391.10856133
49SGK21.09794237
50DYRK21.09719299
51NME11.06974959
52INSRR1.05319464
53MKNK11.03582979
54PLK41.03413500
55PLK31.02799270
56FGFR21.02615204
57WNK40.99566644
58CAMK2B0.98803024
59RIPK40.97192982
60DYRK30.96784299
61AKT30.96334305
62OXSR10.95490689
63DYRK1A0.95482130
64LATS20.95337033
65VRK10.93796217
66BCKDK0.93254996
67CSNK1G20.92767830
68MAPK150.92512940
69FES0.91143949
70ARAF0.89571570
71PIK3CA0.84853714
72NTRK10.80863013
73GRK70.80845990
74STK38L0.80347208
75EPHA30.80056752
76BMPR1B0.78699646
77CDK180.78545346
78PRKCE0.78215681
79PAK30.77671697
80PKN10.76503205
81CAMK1G0.76320619
82KSR20.73720584
83CDK140.73413956
84STK380.72531288
85CDK150.70728451
86PLK10.68180878
87SGK30.66495803
88CDC70.66132548
89SGK10.63082675
90STK160.62742005
91MAP3K60.62018777
92MARK20.61894024
93YES10.61646338
94CDK11A0.61155524
95NEK10.60814682
96CAMK10.59914793
97CSNK1G30.59351860
98ADRBK20.58335271
99BMPR20.57926401
100FGR0.57356793
101CAMK2D0.56645980
102SRPK10.55914887
103CCNB10.55140181
104PRKCH0.55038274
105ERBB40.53654097
106BRSK20.53001708
107PRKD30.52276084
108CAMKK10.51175154
109CAMK2G0.50952961
110FER0.50720830
111CAMKK20.50603094
112TSSK60.50564958
113STK30.50233268
114BUB10.48917102
115ADRBK10.48833923
116TGFBR10.48037434
117RPS6KA20.47883971
118ATM0.47362354
119STK110.47322216
120CDK30.46749409
121PRKCZ0.45327700
122NEK20.44943468
123ROCK20.44833406
124CSNK1A10.44394117
125PTK2B0.44384040
126EPHB20.44229125
127ATR0.43967083
128CSNK1E0.43000674
129CAMK40.42753910
130CHEK20.42753611
131RPS6KA40.42591155
132CSNK1D0.42272446
133RPS6KA30.40936523
134PRKACA0.40537500
135RPS6KA50.39968521
136MAP3K20.39719448
137PRKACB0.38952968
138PRKG10.38679077
139BRAF0.37845970
140PRKCB0.37331092
141MUSK0.36160565
142RET0.35516036
143CSNK1G10.35374773
144CDK80.35238473
145FYN0.34247826
146TAOK30.32243519

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.43833218
2Synaptic vesicle cycle_Homo sapiens_hsa047213.44691102
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.93313215
4GABAergic synapse_Homo sapiens_hsa047272.88764185
5Protein export_Homo sapiens_hsa030602.66309855
6Morphine addiction_Homo sapiens_hsa050322.62086576
7Circadian entrainment_Homo sapiens_hsa047132.49422622
8Glutamatergic synapse_Homo sapiens_hsa047242.44540643
9Olfactory transduction_Homo sapiens_hsa047402.42411590
10Collecting duct acid secretion_Homo sapiens_hsa049662.32214147
11Amphetamine addiction_Homo sapiens_hsa050312.30932633
12Long-term potentiation_Homo sapiens_hsa047202.30244711
13Dopaminergic synapse_Homo sapiens_hsa047282.27438874
14Fanconi anemia pathway_Homo sapiens_hsa034602.16044080
15Serotonergic synapse_Homo sapiens_hsa047262.12963279
16Taste transduction_Homo sapiens_hsa047422.12752288
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10852068
18Steroid biosynthesis_Homo sapiens_hsa001001.94172209
19Cocaine addiction_Homo sapiens_hsa050301.91658325
20Homologous recombination_Homo sapiens_hsa034401.87129853
21RNA polymerase_Homo sapiens_hsa030201.80839561
22Salivary secretion_Homo sapiens_hsa049701.78620868
23Cholinergic synapse_Homo sapiens_hsa047251.78383539
24Long-term depression_Homo sapiens_hsa047301.75484843
25Insulin secretion_Homo sapiens_hsa049111.74824784
26Renin secretion_Homo sapiens_hsa049241.70343545
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68460177
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67867724
29Propanoate metabolism_Homo sapiens_hsa006401.67370630
30Basal transcription factors_Homo sapiens_hsa030221.64439023
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59551117
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.58489752
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57763354
34Caffeine metabolism_Homo sapiens_hsa002321.57480113
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57163705
36Axon guidance_Homo sapiens_hsa043601.56738851
37Oxidative phosphorylation_Homo sapiens_hsa001901.46603212
38Mismatch repair_Homo sapiens_hsa034301.45834432
39Vibrio cholerae infection_Homo sapiens_hsa051101.44752624
40Gastric acid secretion_Homo sapiens_hsa049711.43470519
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42527334
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41060699
43Oxytocin signaling pathway_Homo sapiens_hsa049211.40763764
44Calcium signaling pathway_Homo sapiens_hsa040201.39196410
45RNA degradation_Homo sapiens_hsa030181.37843859
46Linoleic acid metabolism_Homo sapiens_hsa005911.34856854
47Nitrogen metabolism_Homo sapiens_hsa009101.34146108
48Gap junction_Homo sapiens_hsa045401.34121623
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28674665
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26404110
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23180617
52Selenocompound metabolism_Homo sapiens_hsa004501.21099682
53Cardiac muscle contraction_Homo sapiens_hsa042601.19629209
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16293815
55Parkinsons disease_Homo sapiens_hsa050121.15802125
56Non-homologous end-joining_Homo sapiens_hsa034501.15330320
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14553247
58GnRH signaling pathway_Homo sapiens_hsa049121.14475751
59Phototransduction_Homo sapiens_hsa047441.14108605
60Alzheimers disease_Homo sapiens_hsa050101.12678674
61cAMP signaling pathway_Homo sapiens_hsa040241.06808482
62ErbB signaling pathway_Homo sapiens_hsa040121.05828858
63Basal cell carcinoma_Homo sapiens_hsa052171.05776735
64Regulation of autophagy_Homo sapiens_hsa041401.05707529
65Fatty acid elongation_Homo sapiens_hsa000621.04539192
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00274689
67Tryptophan metabolism_Homo sapiens_hsa003801.00151823
68Folate biosynthesis_Homo sapiens_hsa007900.97703099
69Peroxisome_Homo sapiens_hsa041460.97167058
70Melanogenesis_Homo sapiens_hsa049160.96722953
71Nucleotide excision repair_Homo sapiens_hsa034200.92112964
72Estrogen signaling pathway_Homo sapiens_hsa049150.90941499
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89891399
74RNA transport_Homo sapiens_hsa030130.89420005
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88238132
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87632149
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87394709
78Type II diabetes mellitus_Homo sapiens_hsa049300.87372735
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83479701
80DNA replication_Homo sapiens_hsa030300.81683372
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81473967
82Type I diabetes mellitus_Homo sapiens_hsa049400.81310447
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80408639
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79998116
85Ribosome_Homo sapiens_hsa030100.75477759
86Glioma_Homo sapiens_hsa052140.75334787
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.74500756
88Huntingtons disease_Homo sapiens_hsa050160.74407669
89Purine metabolism_Homo sapiens_hsa002300.73996787
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.73571079
91MAPK signaling pathway_Homo sapiens_hsa040100.72319124
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71265216
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70032497
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69915751
95Butanoate metabolism_Homo sapiens_hsa006500.69096005
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66825759
97Base excision repair_Homo sapiens_hsa034100.66700051
98Spliceosome_Homo sapiens_hsa030400.65346288
99Hippo signaling pathway_Homo sapiens_hsa043900.65202738
100Alcoholism_Homo sapiens_hsa050340.65139389
101Ras signaling pathway_Homo sapiens_hsa040140.64414663
102beta-Alanine metabolism_Homo sapiens_hsa004100.64209679
103Rheumatoid arthritis_Homo sapiens_hsa053230.63825242
104Wnt signaling pathway_Homo sapiens_hsa043100.63586158
105Oocyte meiosis_Homo sapiens_hsa041140.63142160
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.60924107
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60589126
108Dilated cardiomyopathy_Homo sapiens_hsa054140.60177004
109Metabolic pathways_Homo sapiens_hsa011000.59336937
110Pyrimidine metabolism_Homo sapiens_hsa002400.57785529
111One carbon pool by folate_Homo sapiens_hsa006700.54983032
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54015684
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.54003399
114Fatty acid metabolism_Homo sapiens_hsa012120.53923398
115Phagosome_Homo sapiens_hsa041450.53223396
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52794283
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52693926
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52168515
119Pancreatic secretion_Homo sapiens_hsa049720.51356197
120Dorso-ventral axis formation_Homo sapiens_hsa043200.50490579
121Choline metabolism in cancer_Homo sapiens_hsa052310.49107956
122Thyroid hormone synthesis_Homo sapiens_hsa049180.48478749
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47518886
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46678589
125Renal cell carcinoma_Homo sapiens_hsa052110.46520932
126Colorectal cancer_Homo sapiens_hsa052100.46511984
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.45979815
128mRNA surveillance pathway_Homo sapiens_hsa030150.45925688
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45385346
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.45026897
131Endometrial cancer_Homo sapiens_hsa052130.42005615
132Glucagon signaling pathway_Homo sapiens_hsa049220.40868667
133Pyruvate metabolism_Homo sapiens_hsa006200.40865231
134Rap1 signaling pathway_Homo sapiens_hsa040150.40300443
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.39477581
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39365028
137Chemical carcinogenesis_Homo sapiens_hsa052040.39101962
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37836144
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36237836
140Prion diseases_Homo sapiens_hsa050200.35744564
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35714018
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35364693
143Ovarian steroidogenesis_Homo sapiens_hsa049130.33653759
144Melanoma_Homo sapiens_hsa052180.32410953
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32293515
146Endocytosis_Homo sapiens_hsa041440.27518807
147Hedgehog signaling pathway_Homo sapiens_hsa043400.27273462
148African trypanosomiasis_Homo sapiens_hsa051430.27179175
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26377120
150Circadian rhythm_Homo sapiens_hsa047100.25328205
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24048376
152Ether lipid metabolism_Homo sapiens_hsa005650.23873448
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23520741

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