SRSF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.05279624
2mitotic sister chromatid segregation (GO:0000070)4.66234325
3telomere maintenance via semi-conservative replication (GO:0032201)4.54614095
4sister chromatid segregation (GO:0000819)4.45448504
5regulation of protein heterodimerization activity (GO:0043497)4.42052855
6DNA strand elongation involved in DNA replication (GO:0006271)4.34251795
7DNA replication initiation (GO:0006270)4.31394428
8regulation of RIG-I signaling pathway (GO:0039535)4.25292666
9DNA strand elongation (GO:0022616)4.20183581
10telomere maintenance via recombination (GO:0000722)4.08150284
11ribosome assembly (GO:0042255)4.07556682
12formation of translation preinitiation complex (GO:0001731)3.94049378
13CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.89465625
14definitive hemopoiesis (GO:0060216)3.89017572
15regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.86383519
16establishment of integrated proviral latency (GO:0075713)3.82228112
17nuclear pore complex assembly (GO:0051292)3.81566562
18DNA unwinding involved in DNA replication (GO:0006268)3.79126556
19mitotic recombination (GO:0006312)3.78042366
20mitotic metaphase plate congression (GO:0007080)3.67512021
21folic acid-containing compound biosynthetic process (GO:0009396)3.64618343
22spliceosomal tri-snRNP complex assembly (GO:0000244)3.63671506
23DNA deamination (GO:0045006)3.62191308
24nuclear pore organization (GO:0006999)3.58709253
25viral genome replication (GO:0019079)3.58172669
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53123750
27telomere maintenance via telomere lengthening (GO:0010833)3.50691973
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.50077196
29IMP biosynthetic process (GO:0006188)3.48332545
30N-acetylneuraminate metabolic process (GO:0006054)3.46274904
31positive regulation of interferon-alpha production (GO:0032727)3.37792109
32DNA replication checkpoint (GO:0000076)3.36966707
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.36942296
34CENP-A containing nucleosome assembly (GO:0034080)3.36912455
35ribosomal small subunit assembly (GO:0000028)3.35989428
36tRNA methylation (GO:0030488)3.33181513
37protein complex localization (GO:0031503)3.33167506
38lymphoid progenitor cell differentiation (GO:0002320)3.30800254
39negative regulation of mRNA processing (GO:0050686)3.29266169
40DNA conformation change (GO:0071103)3.29026350
41chromatin remodeling at centromere (GO:0031055)3.28439311
42chromosome condensation (GO:0030261)3.25336951
43negative regulation of erythrocyte differentiation (GO:0045647)3.24533413
44T cell lineage commitment (GO:0002360)3.22634062
45DNA replication-dependent nucleosome organization (GO:0034723)3.18372154
46DNA replication-dependent nucleosome assembly (GO:0006335)3.18372154
47negative regulation of RNA splicing (GO:0033119)3.17641824
48regulation of interferon-alpha production (GO:0032647)3.17533848
49glomerulus development (GO:0032835)3.17109715
50negative regulation of bone mineralization (GO:0030502)3.16672086
51protein localization to kinetochore (GO:0034501)3.16285594
52regulation of sister chromatid cohesion (GO:0007063)3.16105043
53megakaryocyte development (GO:0035855)3.16056508
54cellular protein complex localization (GO:0034629)3.14617693
55* mRNA splicing, via spliceosome (GO:0000398)3.13644506
56* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.13644506
57base-excision repair (GO:0006284)3.11705940
58peptidyl-arginine omega-N-methylation (GO:0035247)3.11071521
59regulation of translational termination (GO:0006449)3.10124558
60transcription from mitochondrial promoter (GO:0006390)3.09923241
61DNA synthesis involved in DNA repair (GO:0000731)3.09875736
62establishment of viral latency (GO:0019043)3.08681918
63positive regulation of mRNA catabolic process (GO:0061014)3.08223803
64pore complex assembly (GO:0046931)3.07981019
65telomere maintenance (GO:0000723)3.07372016
66meiotic chromosome segregation (GO:0045132)3.07079403
67positive regulation of chromosome segregation (GO:0051984)3.05600500
68kinetochore organization (GO:0051383)3.03977411
69telomere organization (GO:0032200)3.03442432
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03203848
71nuclear envelope organization (GO:0006998)3.02733873
72translesion synthesis (GO:0019985)3.00373221
73double-strand break repair via nonhomologous end joining (GO:0006303)2.99501494
74non-recombinational repair (GO:0000726)2.99501494
75V(D)J recombination (GO:0033151)2.98522434
76negative regulation of chromosome segregation (GO:0051985)2.98169663
77DNA replication-independent nucleosome organization (GO:0034724)2.97528795
78DNA replication-independent nucleosome assembly (GO:0006336)2.97528795
79ribosome biogenesis (GO:0042254)2.97293262
80mitotic sister chromatid cohesion (GO:0007064)2.97273681
81DNA duplex unwinding (GO:0032508)2.95402172
82heterochromatin organization (GO:0070828)2.95038049
83regulation of translational fidelity (GO:0006450)2.94886388
84DNA ligation (GO:0006266)2.94354199
85metaphase plate congression (GO:0051310)2.94151260
86DNA geometric change (GO:0032392)2.92892295
87negative regulation of phagocytosis (GO:0050765)2.92253594
88chromosome segregation (GO:0007059)2.91302485
89regulation of pigment cell differentiation (GO:0050932)2.90943242
90positive regulation of developmental pigmentation (GO:0048087)2.90468253
91nucleobase biosynthetic process (GO:0046112)2.90370837
92* mRNA transport (GO:0051028)2.89537674
93IMP metabolic process (GO:0046040)2.88971456
94folic acid metabolic process (GO:0046655)2.88921798
95DNA topological change (GO:0006265)2.88876531
96DNA packaging (GO:0006323)2.87831829
97regulation of chromosome segregation (GO:0051983)2.86620598
98chromatin assembly or disassembly (GO:0006333)2.86541078
99mismatch repair (GO:0006298)2.83182866
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82939804
101negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82939804
102negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82939804
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.82939804
104negative regulation of sister chromatid segregation (GO:0033046)2.82939804
105regulation of DNA damage checkpoint (GO:2000001)2.82476354
106replicative senescence (GO:0090399)2.81822963
107mitotic nuclear envelope disassembly (GO:0007077)2.81714430
108rRNA transcription (GO:0009303)2.81669133
109mitochondrial RNA metabolic process (GO:0000959)2.80728211
110peptidyl-arginine methylation (GO:0018216)2.79562839
111peptidyl-arginine N-methylation (GO:0035246)2.79562839
112regulation of histone H3-K9 methylation (GO:0051570)2.79447288
113somatic hypermutation of immunoglobulin genes (GO:0016446)2.79427161
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79427161
115protein localization to chromosome (GO:0034502)2.78924445
116deoxyribonucleotide biosynthetic process (GO:0009263)2.78689912
117regulation of DNA endoreduplication (GO:0032875)2.77810090
118RNA stabilization (GO:0043489)2.76444273
119negative regulation of biomineral tissue development (GO:0070168)2.75156675
120kinetochore assembly (GO:0051382)2.73753035
121viral mRNA export from host cell nucleus (GO:0046784)2.72849864
122dosage compensation (GO:0007549)2.68570942
123intra-S DNA damage checkpoint (GO:0031573)2.67651596
124regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67166840
125negative regulation of mRNA metabolic process (GO:1903312)2.66130032
126lateral ventricle development (GO:0021670)2.64677085
127* mRNA export from nucleus (GO:0006406)2.63957603
128ATP-dependent chromatin remodeling (GO:0043044)2.63439443
129histone H2A acetylation (GO:0043968)2.63409495
130purine nucleobase biosynthetic process (GO:0009113)2.62957431
131protein localization to chromosome, centromeric region (GO:0071459)2.60748299
132embryonic hemopoiesis (GO:0035162)2.60257915
1333-UTR-mediated mRNA stabilization (GO:0070935)2.58713228
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58711978
135regulation of mRNA catabolic process (GO:0061013)2.58148409
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.58018590
137* RNA export from nucleus (GO:0006405)2.56867162
138alternative mRNA splicing, via spliceosome (GO:0000380)2.56733430
139DNA replication (GO:0006260)2.56556746
140attachment of spindle microtubules to kinetochore (GO:0008608)2.54579322
141nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.53204817
142nuclear envelope disassembly (GO:0051081)2.52831873
143membrane disassembly (GO:0030397)2.52831873
144response to UV-B (GO:0010224)2.52594020
145deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.52483670
146positive regulation of interferon-beta production (GO:0032728)2.51507882
147bone remodeling (GO:0046849)2.51472153
148histone exchange (GO:0043486)2.51428984
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49067186
150snRNA processing (GO:0016180)2.46249745
151* RNA splicing, via transesterification reactions (GO:0000375)2.45694046
152maturation of 5.8S rRNA (GO:0000460)2.44010938
153* termination of RNA polymerase II transcription (GO:0006369)2.43566003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87475766
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.35716930
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.29973420
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.24514567
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.08861401
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96661203
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.92561610
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.84242509
9SCL_19346495_ChIP-Seq_HPC-7_Human2.68035896
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.41866672
11MYC_22102868_ChIP-Seq_BL_Human2.38938723
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33261857
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26913169
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22600341
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20733509
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13898163
17ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.08879880
18CIITA_25753668_ChIP-Seq_RAJI_Human2.06930834
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.04581542
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03070128
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.02045002
22E2F7_22180533_ChIP-Seq_HELA_Human10.7084833
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97586388
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96510544
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96136615
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93544100
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92049460
28FOXP3_21729870_ChIP-Seq_TREG_Human1.84699013
29AR_21909140_ChIP-Seq_LNCAP_Human1.83516592
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.83489841
31ELK1_19687146_ChIP-ChIP_HELA_Human1.82768059
32VDR_23849224_ChIP-Seq_CD4+_Human1.81146191
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.79784537
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79634325
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78862892
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74923891
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74911818
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73372092
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71249815
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70949173
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69854400
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66531899
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65678068
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64641758
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63258927
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61621390
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60584353
48XRN2_22483619_ChIP-Seq_HELA_Human1.59705738
49VDR_21846776_ChIP-Seq_THP-1_Human1.59458756
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59253487
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54037991
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.51336642
53TTF2_22483619_ChIP-Seq_HELA_Human1.46107420
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44273504
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43959560
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.42545365
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40356987
58SPI1_23547873_ChIP-Seq_NB4_Human1.36749990
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36551671
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.34866630
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32882464
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32872224
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32759717
64CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32680348
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32117452
66DCP1A_22483619_ChIP-Seq_HELA_Human1.31541330
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30693977
68MYB_26560356_Chip-Seq_TH2_Human1.30322637
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30224457
70GABP_19822575_ChIP-Seq_HepG2_Human1.26614007
71MYB_26560356_Chip-Seq_TH1_Human1.26490858
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26030609
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25530867
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24097055
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.23629219
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23595789
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22894011
78VDR_24763502_ChIP-Seq_THP-1_Human1.22703659
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21261816
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20610369
81ZNF263_19887448_ChIP-Seq_K562_Human1.19489576
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16533178
83* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16291632
84KDM5A_27292631_Chip-Seq_BREAST_Human1.15616805
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15597200
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14377860
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.13455973
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11741951
89TFEB_21752829_ChIP-Seq_HELA_Human1.09579701
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07792360
91MAF_26560356_Chip-Seq_TH1_Human1.05764992
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05726944
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.05430565
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05278360
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.04436619
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03168334
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03141233
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01939947
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01813885
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01647796
101TCF7_22412390_ChIP-Seq_EML_Mouse1.01148503
102IRF8_21731497_ChIP-ChIP_J774_Mouse1.00578926
103UTX_26944678_Chip-Seq_JUKART_Human0.98949656
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98912950
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97347181
106NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94558247
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93795012
108CHD1_26751641_Chip-Seq_LNCaP_Human0.93196551
109IRF1_19129219_ChIP-ChIP_H3396_Human0.92320499
110RUNX_20019798_ChIP-Seq_JUKART_Human0.92043571
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91445368
112GATA1_22025678_ChIP-Seq_K562_Human0.89904022
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88683831
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88040772
115NCOR1_26117541_ChIP-Seq_K562_Human0.86959757
116MAF_26560356_Chip-Seq_TH2_Human0.86870018
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86788258
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86121341
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86057524
120GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84663679
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.84273857
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84156350
123NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83792915
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.82732487
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82401460
126MYC_18940864_ChIP-ChIP_HL60_Human0.82054351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.51521692
2MP0010094_abnormal_chromosome_stability3.48783593
3MP0003693_abnormal_embryo_hatching3.37434331
4MP0008057_abnormal_DNA_replication3.24881077
5MP0005075_abnormal_melanosome_morpholog2.89974283
6MP0000372_irregular_coat_pigmentation2.74521761
7MP0003111_abnormal_nucleus_morphology2.70298492
8MP0003077_abnormal_cell_cycle2.58686238
9MP0001348_abnormal_lacrimal_gland2.50660894
10MP0008007_abnormal_cellular_replicative2.38758893
11MP0008058_abnormal_DNA_repair2.37605653
12MP0004808_abnormal_hematopoietic_stem2.34374539
13MP0003763_abnormal_thymus_physiology2.28588998
14MP0004957_abnormal_blastocyst_morpholog2.26721492
15MP0002009_preneoplasia2.21883525
16MP0000490_abnormal_crypts_of2.11296508
17MP0006054_spinal_hemorrhage2.10453890
18MP0009333_abnormal_splenocyte_physiolog1.94334758
19MP0005397_hematopoietic_system_phenotyp1.80599443
20MP0001545_abnormal_hematopoietic_system1.80599443
21MP0000015_abnormal_ear_pigmentation1.77300468
22MP0005451_abnormal_body_composition1.75552092
23MP0002095_abnormal_skin_pigmentation1.67842905
24MP0003943_abnormal_hepatobiliary_system1.64494363
25MP0004381_abnormal_hair_follicle1.61421554
26MP0009697_abnormal_copulation1.53052422
27MP0004185_abnormal_adipocyte_glucose1.52760543
28MP0004147_increased_porphyrin_level1.51753395
29MP0009672_abnormal_birth_weight1.47962109
30MP0005408_hypopigmentation1.47591352
31MP0000350_abnormal_cell_proliferation1.45619406
32MP0006292_abnormal_olfactory_placode1.45171315
33MP0003567_abnormal_fetal_cardiomyocyte1.43769425
34* MP0002398_abnormal_bone_marrow1.41911095
35MP0002166_altered_tumor_susceptibility1.40296207
36MP0005671_abnormal_response_to1.39209425
37MP0003786_premature_aging1.38835904
38MP0002160_abnormal_reproductive_system1.37243544
39MP0008877_abnormal_DNA_methylation1.36343846
40MP0010307_abnormal_tumor_latency1.34440523
41MP0005174_abnormal_tail_pigmentation1.33595227
42MP0001188_hyperpigmentation1.33499642
43MP0008932_abnormal_embryonic_tissue1.33433629
44MP0001835_abnormal_antigen_presentation1.33352780
45* MP0000689_abnormal_spleen_morphology1.28941975
46MP0005501_abnormal_skin_physiology1.28166919
47MP0005409_darkened_coat_color1.27982380
48* MP0000703_abnormal_thymus_morphology1.27731828
49MP0002085_abnormal_embryonic_tissue1.25801937
50MP0003890_abnormal_embryonic-extraembry1.24882335
51MP0010352_gastrointestinal_tract_polyps1.24588156
52MP0000465_gastrointestinal_hemorrhage1.24463071
53* MP0002722_abnormal_immune_system1.23184261
54MP0000566_synostosis1.21759065
55MP0002075_abnormal_coat/hair_pigmentati1.17380833
56MP0005389_reproductive_system_phenotype1.15455494
57MP0002084_abnormal_developmental_patter1.13433787
58MP0003941_abnormal_skin_development1.13379659
59MP0002006_tumorigenesis1.13118975
60MP0002019_abnormal_tumor_incidence1.12855277
61MP0000371_diluted_coat_color1.12710667
62MP0002877_abnormal_melanocyte_morpholog1.12235894
63MP0002796_impaired_skin_barrier1.10588717
64MP0001919_abnormal_reproductive_system1.09796836
65MP0010234_abnormal_vibrissa_follicle1.09715562
66MP0000537_abnormal_urethra_morphology1.06684031
67MP0001186_pigmentation_phenotype1.05118583
68MP0002933_joint_inflammation1.04116315
69MP0002132_abnormal_respiratory_system1.03160274
70* MP0000716_abnormal_immune_system1.02157490
71MP0001119_abnormal_female_reproductive1.02138447
72MP0002420_abnormal_adaptive_immunity1.01944558
73MP0002177_abnormal_outer_ear1.01089987
74MP0001819_abnormal_immune_cell1.00885403
75MP0000313_abnormal_cell_death1.00866902
76MP0004782_abnormal_surfactant_physiolog1.00371247
77MP0002452_abnormal_antigen_presenting1.00215214
78MP0001672_abnormal_embryogenesis/_devel0.99576999
79MP0005380_embryogenesis_phenotype0.99576999
80* MP0002429_abnormal_blood_cell0.99228061
81MP0005621_abnormal_cell_physiology0.99108050
82MP0001346_abnormal_lacrimal_gland0.98964601
83MP0003221_abnormal_cardiomyocyte_apopto0.98056858
84MP0003718_maternal_effect0.97602398
85MP0002938_white_spotting0.96360679
86MP0001661_extended_life_span0.96068104
87MP0004233_abnormal_muscle_weight0.95386751
88MP0001800_abnormal_humoral_immune0.94446132
89MP0003942_abnormal_urinary_system0.93371776
90MP0006035_abnormal_mitochondrial_morpho0.92416660
91MP0002086_abnormal_extraembryonic_tissu0.92047938
92MP0005464_abnormal_platelet_physiology0.90387104
93MP0005076_abnormal_cell_differentiation0.89526515
94MP0003315_abnormal_perineum_morphology0.89328640
95MP0003984_embryonic_growth_retardation0.89020693
96MP0001915_intracranial_hemorrhage0.87752326
97MP0005384_cellular_phenotype0.86776992
98MP0002210_abnormal_sex_determination0.86371737
99MP0008961_abnormal_basal_metabolism0.86120540
100MP0001697_abnormal_embryo_size0.84680081
101MP0000428_abnormal_craniofacial_morphol0.83531828
102MP0001730_embryonic_growth_arrest0.83371336
103MP0001853_heart_inflammation0.82438719
104MP0002088_abnormal_embryonic_growth/wei0.82110832
105MP0000049_abnormal_middle_ear0.82035115
106MP0008995_early_reproductive_senescence0.80755215
107MP0008789_abnormal_olfactory_epithelium0.80661200
108MP0003121_genomic_imprinting0.79398468
109MP0006036_abnormal_mitochondrial_physio0.79123088
110MP0003123_paternal_imprinting0.78643392
111MP0002723_abnormal_immune_serum0.78424073
112* MP0002080_prenatal_lethality0.78370952
113MP0009278_abnormal_bone_marrow0.77900628
114MP0002148_abnormal_hypersensitivity_rea0.77787845
115MP0001873_stomach_inflammation0.76509730
116MP0004197_abnormal_fetal_growth/weight/0.74885506
117MP0009785_altered_susceptibility_to0.74779134
118MP0000477_abnormal_intestine_morphology0.74079404
119MP0001879_abnormal_lymphatic_vessel0.74050202
120MP0000358_abnormal_cell_content/0.74043152
121MP0000767_abnormal_smooth_muscle0.73929818
122MP0002405_respiratory_system_inflammati0.73471814
123MP0000681_abnormal_thyroid_gland0.72896599
124MP0009703_decreased_birth_body0.72649201
125MP0002419_abnormal_innate_immunity0.72264323
126MP0001145_abnormal_male_reproductive0.71492741
127MP0001216_abnormal_epidermal_layer0.70816600
128MP0001849_ear_inflammation0.70624847
129MP0005220_abnormal_exocrine_pancreas0.70136708
130MP0004264_abnormal_extraembryonic_tissu0.68769441
131MP0008260_abnormal_autophagy0.67085306
132MP0003656_abnormal_erythrocyte_physiolo0.66612804
133MP0003699_abnormal_female_reproductive0.66521215
134MP0002970_abnormal_white_adipose0.65801144
135MP0001929_abnormal_gametogenesis0.65315534
136MP0003705_abnormal_hypodermis_morpholog0.65279815
137MP0001727_abnormal_embryo_implantation0.64943883
138MP0009931_abnormal_skin_appearance0.62311139
139MP0002111_abnormal_tail_morphology0.62036270
140MP0003806_abnormal_nucleotide_metabolis0.61828782
141MP0003453_abnormal_keratinocyte_physiol0.60553810
142MP0002163_abnormal_gland_morphology0.60483614
143MP0001881_abnormal_mammary_gland0.58672495
144MP0000003_abnormal_adipose_tissue0.57581363
145MP0005623_abnormal_meninges_morphology0.57181608

Predicted human phenotypes

RankGene SetZ-score
1Selective tooth agenesis (HP:0001592)6.51899225
2Microvesicular hepatic steatosis (HP:0001414)4.19170183
3Chromsome breakage (HP:0040012)3.83793970
4Aplastic anemia (HP:0001915)3.71738168
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.66791534
6Type I transferrin isoform profile (HP:0003642)3.51561890
7Progressive muscle weakness (HP:0003323)3.45055588
8Spinal cord lesions (HP:0100561)3.40309617
9Syringomyelia (HP:0003396)3.40309617
10Birth length less than 3rd percentile (HP:0003561)3.27880633
1111 pairs of ribs (HP:0000878)3.12251337
12Abnormality of the fingertips (HP:0001211)3.09291782
13Reduced antithrombin III activity (HP:0001976)3.01442938
14Multiple enchondromatosis (HP:0005701)3.01117875
15Myelodysplasia (HP:0002863)2.70406146
16Proximal placement of thumb (HP:0009623)2.70208245
17Abnormality of the columella (HP:0009929)2.70106104
18Clubbing of toes (HP:0100760)2.67419913
19Abnormality of chromosome stability (HP:0003220)2.67059659
20Ragged-red muscle fibers (HP:0003200)2.61822887
21Progressive external ophthalmoplegia (HP:0000590)2.60716039
22Deviation of the thumb (HP:0009603)2.58446254
23Acute myeloid leukemia (HP:0004808)2.55547539
24Long eyelashes (HP:0000527)2.50277052
25Mediastinal lymphadenopathy (HP:0100721)2.49516693
26Pulmonary fibrosis (HP:0002206)2.48817041
27Oligodontia (HP:0000677)2.46095180
28Thrombocytosis (HP:0001894)2.45728241
29Squamous cell carcinoma (HP:0002860)2.44422231
30Lymphoma (HP:0002665)2.41453182
31Impulsivity (HP:0100710)2.39776884
32Meckel diverticulum (HP:0002245)2.36133465
33Abnormality of the preputium (HP:0100587)2.35452404
34Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33922637
35Abnormal protein N-linked glycosylation (HP:0012347)2.33922637
36Abnormal protein glycosylation (HP:0012346)2.33922637
37Abnormal glycosylation (HP:0012345)2.33922637
38Septate vagina (HP:0001153)2.32471976
39Abnormal lung lobation (HP:0002101)2.31937419
40Optic nerve coloboma (HP:0000588)2.31795885
41Abnormal number of erythroid precursors (HP:0012131)2.30764546
42Ectopic kidney (HP:0000086)2.30475570
43Absent radius (HP:0003974)2.28421769
44Medulloblastoma (HP:0002885)2.25701303
45Reticulocytopenia (HP:0001896)2.22486794
46Fatigue (HP:0012378)2.21369105
47Abnormality of the ileum (HP:0001549)2.21106123
48Petechiae (HP:0000967)2.20329113
49Small intestinal stenosis (HP:0012848)2.19127815
50Duodenal stenosis (HP:0100867)2.19127815
51Abnormality of the heme biosynthetic pathway (HP:0010472)2.19047027
52Premature ovarian failure (HP:0008209)2.16632547
53Prolonged bleeding time (HP:0003010)2.15815126
54Overlapping toe (HP:0001845)2.15470277
55Combined immunodeficiency (HP:0005387)2.15174012
56IgM deficiency (HP:0002850)2.14586274
57Short middle phalanx of the 5th finger (HP:0004220)2.11697895
58Abnormality of the peritoneum (HP:0002585)2.10670591
59Cafe-au-lait spot (HP:0000957)2.10478973
60Patellar aplasia (HP:0006443)2.10056079
61Shoulder girdle muscle weakness (HP:0003547)2.09357854
62Horseshoe kidney (HP:0000085)2.09185383
63High anterior hairline (HP:0009890)2.08414378
64Aplasia involving forearm bones (HP:0009822)2.08110845
65Absent forearm bone (HP:0003953)2.08110845
66Abnormality of the renal collecting system (HP:0004742)2.05598796
67Abnormality of chromosome segregation (HP:0002916)2.05574971
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.05427346
69Short 4th metacarpal (HP:0010044)2.05220413
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05220413
71Abnormality of the prostate (HP:0008775)2.04689186
72Nephroblastoma (Wilms tumor) (HP:0002667)2.02290489
73Ureteral duplication (HP:0000073)2.02199149
74Cortical dysplasia (HP:0002539)2.02046871
75Breast hypoplasia (HP:0003187)2.01607083
76Flared metaphyses (HP:0003015)2.01083835
77Poikiloderma (HP:0001029)2.00735700
78Carpal bone hypoplasia (HP:0001498)2.00256576
79Hyperacusis (HP:0010780)1.99253669
80Bone marrow hypocellularity (HP:0005528)1.98948790
81Trismus (HP:0000211)1.98589425
82Osteomalacia (HP:0002749)1.98252794
83Breech presentation (HP:0001623)1.98058200
84IgA deficiency (HP:0002720)1.97829299
85Chronic otitis media (HP:0000389)1.97626132
86Aplasia/Hypoplasia of the patella (HP:0006498)1.97552664
87Aplasia/Hypoplasia of the thymus (HP:0010515)1.96311826
88Abnormality of cells of the erythroid lineage (HP:0012130)1.95037627
89Prominent nose (HP:0000448)1.94614837
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93988210
91Volvulus (HP:0002580)1.93217300
92Short thumb (HP:0009778)1.93006176
93Meningitis (HP:0001287)1.92410478
94Broad distal phalanx of finger (HP:0009836)1.92320309
95Abnormal spermatogenesis (HP:0008669)1.91897617
96Abnormality of the umbilical cord (HP:0010881)1.91076667
97Facial cleft (HP:0002006)1.90413481
98Panhypogammaglobulinemia (HP:0003139)1.89910720
99Absent frontal sinuses (HP:0002688)1.88359059
100Embryonal renal neoplasm (HP:0011794)1.87951340
101Abnormality of the fetal cardiovascular system (HP:0010948)1.86726562
102Abnormal umbilical cord blood vessels (HP:0011403)1.86726562
103Single umbilical artery (HP:0001195)1.86726562
104Pseudobulbar signs (HP:0002200)1.86333110
105Basal cell carcinoma (HP:0002671)1.86176041
106Poor head control (HP:0002421)1.85611893
107Abnormality of cochlea (HP:0000375)1.84962670
108Abnormality of the intervertebral disk (HP:0005108)1.82981411
109Lip pit (HP:0100267)1.82490771
110Dislocated radial head (HP:0003083)1.82391809
111Seborrheic dermatitis (HP:0001051)1.81371523
112Stomach cancer (HP:0012126)1.81206940
113Amaurosis fugax (HP:0100576)1.81151622
114Abnormality of the pleura (HP:0002103)1.80603737
115Severe combined immunodeficiency (HP:0004430)1.80540947
116Entropion (HP:0000621)1.80300973
117Oral leukoplakia (HP:0002745)1.79623560
118Abnormality of the nasal septum (HP:0000419)1.79537468
119Deep philtrum (HP:0002002)1.79464758
120Hypertensive crisis (HP:0100735)1.78834886
121Slender long bone (HP:0003100)1.77959161
122Abnormality of the anterior horn cell (HP:0006802)1.77677362
123Degeneration of anterior horn cells (HP:0002398)1.77677362
124Microretrognathia (HP:0000308)1.77106704
125Cutaneous melanoma (HP:0012056)1.76741487
126Sloping forehead (HP:0000340)1.76523609
127Choanal atresia (HP:0000453)1.75585078
128Abnormality of DNA repair (HP:0003254)1.74834508
129Tubulointerstitial nephritis (HP:0001970)1.74235536
130Short 5th finger (HP:0009237)1.73487651
131Atresia of the external auditory canal (HP:0000413)1.73389219
132Cleft eyelid (HP:0000625)1.71816948
133Hypergonadotropic hypogonadism (HP:0000815)1.71806984
134Embryonal neoplasm (HP:0002898)1.71704613
135B lymphocytopenia (HP:0010976)1.71281028
136Abnormality of B cell number (HP:0010975)1.71281028
137Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70956874
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70745300
139Type 2 muscle fiber atrophy (HP:0003554)1.70623558
140Duplicated collecting system (HP:0000081)1.69755535
141Rough bone trabeculation (HP:0100670)1.68588241
142Abnormality of the duodenum (HP:0002246)1.68341280
143Abnormality of glycolysis (HP:0004366)1.68196734
144Myositis (HP:0100614)1.68110359
145Abnormality of the carotid arteries (HP:0005344)1.67898172
146Long clavicles (HP:0000890)1.67659766
147Capillary hemangiomas (HP:0005306)1.67418369
148Acute lymphatic leukemia (HP:0006721)1.66816711
149Abnormality of the radial head (HP:0003995)1.65731355
150Abnormal number of incisors (HP:0011064)1.65041871
151Azoospermia (HP:0000027)1.62023921
152Increased nuchal translucency (HP:0010880)1.61735832
153Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.60310253
154Pancytopenia (HP:0001876)1.59529961
155Recurrent viral infections (HP:0004429)1.59102376
156Neoplasm of the adrenal cortex (HP:0100641)1.57692401
157Muscle fiber atrophy (HP:0100295)1.56934365
158Asymmetry of the thorax (HP:0001555)1.56645525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.31247321
2SMG13.27141200
3MKNK13.18591325
4MKNK23.05687944
5WEE12.84534488
6MAP3K102.60410828
7SRPK12.59337445
8ZAK2.53410966
9SCYL22.51531970
10VRK22.26956018
11ACVR1B2.23507101
12BRSK22.06709178
13YES12.02536210
14NEK11.91440989
15CDK81.90403568
16TEC1.85368293
17BCKDK1.85366774
18ERBB31.77090254
19MAP4K11.77005238
20TGFBR11.71176943
21CDK121.68759540
22TAF11.68459994
23VRK11.67508617
24FLT31.63844817
25KIT1.59447162
26TSSK61.58140662
27ATR1.57893167
28CDK71.57562119
29PIM11.57176837
30CLK11.54154871
31PBK1.54069386
32NEK21.53711895
33EEF2K1.53167697
34TESK21.50583235
35CDK61.47719486
36BTK1.47453485
37PIM21.45116636
38BRD41.31960444
39MAP2K31.31790191
40RPS6KA41.31543870
41SIK31.30764813
42IRAK41.28941337
43TRIB31.28732803
44RPS6KB21.27178483
45PASK1.26023835
46EIF2AK31.23129417
47JAK31.19839939
48TXK1.18097467
49NME21.14594638
50CDK41.13580824
51ICK1.12138503
52PLK41.11543694
53KDR1.10460288
54NEK91.08728923
55PLK31.07587958
56NLK1.05226340
57STK161.05090674
58STK41.03091801
59BUB11.01061160
60AURKA1.00029356
61MAP3K80.98852712
62CHUK0.97473353
63IRAK30.94530126
64MAP3K140.93069779
65TNIK0.91978487
66MAPK110.90757422
67RPS6KA60.90359527
68EIF2AK10.89891445
69CHEK20.89380821
70MUSK0.88946028
71PLK10.88739236
72STK100.87341097
73AURKB0.86674523
74TTK0.85832021
75ATM0.81912262
76TRPM70.80924332
77CCNB10.80595355
78DYRK30.80065159
79TAOK20.78350758
80ZAP700.78016624
81TGFBR20.75805332
82MST40.75407987
83PAK40.74959935
84CDK30.74677879
85BRSK10.74541747
86CHEK10.74237122
87CSF1R0.74067291
88SGK20.73585947
89RPS6KL10.73355477
90RPS6KC10.73355477
91CDK20.70545112
92HIPK20.67922332
93MAPK40.67312669
94ALK0.65698398
95PRPF4B0.63656963
96TNK20.62692995
97TRIM280.60218504
98RPS6KB10.57486011
99RAF10.56421868
100AKT20.56162438
101IKBKB0.55142376
102MAP3K60.52836716
103HCK0.52826538
104CSNK2A10.51726061
105EIF2AK20.51356134
106LYN0.49200496
107MAPK30.48895960
108CDK90.47486921
109TIE10.47239677
110FGFR40.47051693
111SYK0.46726463
112SGK30.46711583
113MTOR0.46362677
114NUAK10.46008364
115MELK0.45926186
116NME10.45015577
117CDK10.44902159
118CAMK40.43625918
119MATK0.43481867
120MAPKAPK50.42654028
121FRK0.42157342
122ITK0.42083685
123RPS6KA50.41906818
124DAPK10.41252035
125TAOK30.40360966
126IRAK20.39207938
127MAP2K20.36196194
128CDK11A0.35310313
129CSNK1A1L0.35154116
130CSNK2A20.34633773
131CSNK1G30.32454324
132CDK180.29714089
133CDK150.29644916
134RPS6KA10.28341206
135MAPK140.27788438
136PRKDC0.25993920
137CDK140.25959849
138BRAF0.24341947
139GSK3B0.22232791

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80672693
2Mismatch repair_Homo sapiens_hsa034303.61736593
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.30436045
4Base excision repair_Homo sapiens_hsa034103.20265608
5Homologous recombination_Homo sapiens_hsa034402.66519740
6* Spliceosome_Homo sapiens_hsa030402.63504427
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52481913
8Cell cycle_Homo sapiens_hsa041102.50122894
9One carbon pool by folate_Homo sapiens_hsa006702.30966670
10Nucleotide excision repair_Homo sapiens_hsa034202.25788105
11Fanconi anemia pathway_Homo sapiens_hsa034602.24165480
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19689414
13RNA transport_Homo sapiens_hsa030132.07917706
14RNA degradation_Homo sapiens_hsa030182.00147652
15Non-homologous end-joining_Homo sapiens_hsa034501.95441378
16Basal transcription factors_Homo sapiens_hsa030221.87168370
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.80986307
18RNA polymerase_Homo sapiens_hsa030201.79510421
19Pyrimidine metabolism_Homo sapiens_hsa002401.77974361
20* Herpes simplex infection_Homo sapiens_hsa051681.66083980
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64121260
22Sulfur relay system_Homo sapiens_hsa041221.60740760
23Biosynthesis of amino acids_Homo sapiens_hsa012301.59757003
24mRNA surveillance pathway_Homo sapiens_hsa030151.49382495
25Ribosome_Homo sapiens_hsa030101.44192456
26p53 signaling pathway_Homo sapiens_hsa041151.38756338
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34660061
28Thyroid cancer_Homo sapiens_hsa052161.26774350
29Notch signaling pathway_Homo sapiens_hsa043301.25675949
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.22778883
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21697254
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.21242556
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21233521
34Measles_Homo sapiens_hsa051621.18735866
35Primary immunodeficiency_Homo sapiens_hsa053401.16033428
36Small cell lung cancer_Homo sapiens_hsa052221.15793139
37Pentose phosphate pathway_Homo sapiens_hsa000301.12507781
38Hepatitis B_Homo sapiens_hsa051611.11933954
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11082274
40Epstein-Barr virus infection_Homo sapiens_hsa051691.05884682
41N-Glycan biosynthesis_Homo sapiens_hsa005101.04404581
42Antigen processing and presentation_Homo sapiens_hsa046121.02370744
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.97795524
44Purine metabolism_Homo sapiens_hsa002300.95933204
45Carbon metabolism_Homo sapiens_hsa012000.95551177
46Viral carcinogenesis_Homo sapiens_hsa052030.95283633
47MicroRNAs in cancer_Homo sapiens_hsa052060.95153186
48HTLV-I infection_Homo sapiens_hsa051660.93008515
49Bladder cancer_Homo sapiens_hsa052190.92346908
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91447773
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87991400
52Prostate cancer_Homo sapiens_hsa052150.87645783
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86186446
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.85446134
55Protein export_Homo sapiens_hsa030600.85034677
56Colorectal cancer_Homo sapiens_hsa052100.83920940
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83799072
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82497958
59Apoptosis_Homo sapiens_hsa042100.82177672
60Folate biosynthesis_Homo sapiens_hsa007900.80676032
61Legionellosis_Homo sapiens_hsa051340.80007881
62Hematopoietic cell lineage_Homo sapiens_hsa046400.79692977
63Oocyte meiosis_Homo sapiens_hsa041140.79636570
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.79430459
65Influenza A_Homo sapiens_hsa051640.79062077
66Selenocompound metabolism_Homo sapiens_hsa004500.78582599
67Acute myeloid leukemia_Homo sapiens_hsa052210.77571947
68Proteasome_Homo sapiens_hsa030500.77565773
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.75402151
70Chronic myeloid leukemia_Homo sapiens_hsa052200.73087556
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67642368
72Leishmaniasis_Homo sapiens_hsa051400.66429328
73Toxoplasmosis_Homo sapiens_hsa051450.65053755
74TGF-beta signaling pathway_Homo sapiens_hsa043500.63623353
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62715527
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62591595
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61493762
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57415792
79Fructose and mannose metabolism_Homo sapiens_hsa000510.56513463
80Systemic lupus erythematosus_Homo sapiens_hsa053220.56269234
81B cell receptor signaling pathway_Homo sapiens_hsa046620.52718361
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.52643921
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52257936
84Pathways in cancer_Homo sapiens_hsa052000.52090208
85Lysine degradation_Homo sapiens_hsa003100.49598119
86Pyruvate metabolism_Homo sapiens_hsa006200.48227133
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47899799
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46621032
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46007091
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45851729
91Alcoholism_Homo sapiens_hsa050340.43369254
92Arachidonic acid metabolism_Homo sapiens_hsa005900.43274897
93Shigellosis_Homo sapiens_hsa051310.42741530
94Phototransduction_Homo sapiens_hsa047440.42533286
95Non-small cell lung cancer_Homo sapiens_hsa052230.42425261
96Other glycan degradation_Homo sapiens_hsa005110.42333697
97Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40816195
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40070290
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39923883
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37906593
101T cell receptor signaling pathway_Homo sapiens_hsa046600.37635016
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37468485
103Steroid biosynthesis_Homo sapiens_hsa001000.37052916
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36858100
105Fatty acid elongation_Homo sapiens_hsa000620.36596249
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36014491
107TNF signaling pathway_Homo sapiens_hsa046680.35811327
108Endometrial cancer_Homo sapiens_hsa052130.34303818
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34062669
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33043636
111FoxO signaling pathway_Homo sapiens_hsa040680.32474620
112Vitamin B6 metabolism_Homo sapiens_hsa007500.31312307
113HIF-1 signaling pathway_Homo sapiens_hsa040660.30995442
114Melanoma_Homo sapiens_hsa052180.30892618
115Platelet activation_Homo sapiens_hsa046110.30174107
116Adherens junction_Homo sapiens_hsa045200.29995704
117Wnt signaling pathway_Homo sapiens_hsa043100.29801589
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29580262
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.29574275
120Galactose metabolism_Homo sapiens_hsa000520.27088777
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26682810
122Viral myocarditis_Homo sapiens_hsa054160.25107949
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25057162
124Pancreatic cancer_Homo sapiens_hsa052120.24741106
125Tuberculosis_Homo sapiens_hsa051520.24595755
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24536688
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24395418
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24244495
129Asthma_Homo sapiens_hsa053100.22417393
130Hepatitis C_Homo sapiens_hsa051600.22100791
131Glutathione metabolism_Homo sapiens_hsa004800.19187451
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18486404
133Glioma_Homo sapiens_hsa052140.17899780
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17827108
135mTOR signaling pathway_Homo sapiens_hsa041500.16136600
136Inositol phosphate metabolism_Homo sapiens_hsa005620.13633913

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