SRSF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.70809200
2DNA strand elongation involved in DNA replication (GO:0006271)4.69126866
3telomere maintenance via semi-conservative replication (GO:0032201)4.62693706
4DNA strand elongation (GO:0022616)4.48507058
5kinetochore organization (GO:0051383)4.47162928
6negative regulation of DNA-dependent DNA replication (GO:2000104)4.37414007
7CENP-A containing nucleosome assembly (GO:0034080)4.34522762
8mitotic recombination (GO:0006312)4.29944102
9chromatin remodeling at centromere (GO:0031055)4.26974411
10telomere maintenance via recombination (GO:0000722)4.25342492
11DNA replication initiation (GO:0006270)4.24239276
12protein localization to kinetochore (GO:0034501)4.20611350
13replication fork processing (GO:0031297)4.16432593
14DNA replication-independent nucleosome assembly (GO:0006336)4.07324099
15DNA replication-independent nucleosome organization (GO:0034724)4.07324099
16ribosomal small subunit assembly (GO:0000028)4.05111187
17regulation of DNA endoreduplication (GO:0032875)4.03650766
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.98841826
19regulation of mitotic spindle checkpoint (GO:1903504)3.95803931
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.95803931
21regulation of centriole replication (GO:0046599)3.95763620
22DNA replication checkpoint (GO:0000076)3.95483858
23kinetochore assembly (GO:0051382)3.92528516
24proteasome assembly (GO:0043248)3.81442950
25mitotic metaphase plate congression (GO:0007080)3.80966694
26telomere maintenance via telomere lengthening (GO:0010833)3.76566726
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.75852278
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.75230664
29negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.75094218
30nuclear pore organization (GO:0006999)3.72521077
31DNA catabolic process, exonucleolytic (GO:0000738)3.67301709
32double-strand break repair via nonhomologous end joining (GO:0006303)3.65012966
33non-recombinational repair (GO:0000726)3.65012966
34protein localization to chromosome, centromeric region (GO:0071459)3.63347986
35negative regulation of RNA splicing (GO:0033119)3.61995783
36DNA topological change (GO:0006265)3.60431376
37metaphase plate congression (GO:0051310)3.60036130
38attachment of spindle microtubules to kinetochore (GO:0008608)3.56939049
39maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.55655028
40nuclear pore complex assembly (GO:0051292)3.55622757
41histone exchange (GO:0043486)3.54191065
42microtubule depolymerization (GO:0007019)3.54098611
43mitotic chromosome condensation (GO:0007076)3.53843093
44maturation of SSU-rRNA (GO:0030490)3.52617493
45mitotic nuclear envelope disassembly (GO:0007077)3.51865024
46DNA replication-dependent nucleosome organization (GO:0034723)3.47182714
47DNA replication-dependent nucleosome assembly (GO:0006335)3.47182714
48nucleobase biosynthetic process (GO:0046112)3.42164363
49mitotic sister chromatid cohesion (GO:0007064)3.41057696
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.38481654
51negative regulation of mRNA processing (GO:0050686)3.33609557
52IMP biosynthetic process (GO:0006188)3.31763059
53mitotic G2/M transition checkpoint (GO:0044818)3.31675857
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.31125957
55somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31125957
56sister chromatid segregation (GO:0000819)3.30767614
57ribosome assembly (GO:0042255)3.27856467
58establishment of chromosome localization (GO:0051303)3.27520403
59viral transcription (GO:0019083)3.27394494
60cullin deneddylation (GO:0010388)3.27383090
61translational termination (GO:0006415)3.25551786
62formation of translation preinitiation complex (GO:0001731)3.25227128
63DNA duplex unwinding (GO:0032508)3.24986056
64postreplication repair (GO:0006301)3.24587600
65membrane disassembly (GO:0030397)3.24565282
66nuclear envelope disassembly (GO:0051081)3.24565282
67mitotic sister chromatid segregation (GO:0000070)3.24422536
68purine nucleobase biosynthetic process (GO:0009113)3.24278475
69DNA geometric change (GO:0032392)3.23960769
70negative regulation of DNA recombination (GO:0045910)3.23723702
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22574835
72recombinational repair (GO:0000725)3.21412089
73ATP-dependent chromatin remodeling (GO:0043044)3.20772808
74double-strand break repair via homologous recombination (GO:0000724)3.20158186
75centriole replication (GO:0007099)3.18398310
76regulation of spindle organization (GO:0090224)3.16921199
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16074110
78somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.15416801
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.15416801
80isotype switching (GO:0045190)3.15416801
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14245565
82spindle checkpoint (GO:0031577)3.12878849
83DNA damage response, detection of DNA damage (GO:0042769)3.12494772
84regulation of centrosome cycle (GO:0046605)3.11821680
85* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.11808079
86* mRNA splicing, via spliceosome (GO:0000398)3.11808079
87* RNA splicing, via transesterification reactions (GO:0000375)3.11195125
88anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10688920
89resolution of meiotic recombination intermediates (GO:0000712)3.10219531
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10053942
91synapsis (GO:0007129)3.08850801
92viral mRNA export from host cell nucleus (GO:0046784)3.07864291
93spindle assembly checkpoint (GO:0071173)3.07630379
94meiotic chromosome segregation (GO:0045132)3.07618460
95ribosomal large subunit biogenesis (GO:0042273)3.07264061
96DNA ligation (GO:0006266)3.06316153
97telomere maintenance (GO:0000723)3.06232619
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06006580
99negative regulation of sister chromatid segregation (GO:0033046)3.06006580
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.06006580
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06006580
102histone mRNA metabolic process (GO:0008334)3.04988682
103telomere organization (GO:0032200)3.04701846
104mismatch repair (GO:0006298)3.03422668
105chromatin assembly or disassembly (GO:0006333)3.02575503
106negative regulation of chromosome segregation (GO:0051985)3.02339144
107chromosome segregation (GO:0007059)3.02093205
108response to X-ray (GO:0010165)3.01273035
109spliceosomal snRNP assembly (GO:0000387)3.00088635
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99925285
111regulation of centrosome duplication (GO:0010824)2.99289753
112mitotic spindle assembly checkpoint (GO:0007094)2.99122375
113protein deneddylation (GO:0000338)2.98815057
114ribosomal small subunit biogenesis (GO:0042274)2.98306044
115negative regulation of mRNA metabolic process (GO:1903312)2.98057985
116exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97098570
117negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95726206
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95571532
119spliceosomal complex assembly (GO:0000245)2.94695988
120mitotic spindle checkpoint (GO:0071174)2.94026840
121nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93900853
122regulation of double-strand break repair via homologous recombination (GO:0010569)2.93838564
123intra-S DNA damage checkpoint (GO:0031573)2.93794956
124negative regulation of mitosis (GO:0045839)2.93715274
125* termination of RNA polymerase II transcription (GO:0006369)2.93578648
126histone H2A acetylation (GO:0043968)2.93547599
127translational elongation (GO:0006414)2.93156018
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92119571
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91908056
130dosage compensation (GO:0007549)2.91767413
131transcription-coupled nucleotide-excision repair (GO:0006283)2.90767143
132regulation of chromosome segregation (GO:0051983)2.89086100
133translational initiation (GO:0006413)2.88375844
134RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.88032552
135regulation of helicase activity (GO:0051095)2.86490611
136DNA conformation change (GO:0071103)2.86330774
137establishment of integrated proviral latency (GO:0075713)2.86202971
138translesion synthesis (GO:0019985)2.85766079
139DNA double-strand break processing (GO:0000729)2.85425257
140SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85096279
141ribonucleoprotein complex biogenesis (GO:0022613)2.84951836
142regulation of mitotic sister chromatid separation (GO:0010965)2.83875944
143regulation of mitotic sister chromatid segregation (GO:0033047)2.83875944
144regulation of sister chromatid segregation (GO:0033045)2.83875944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.85394274
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.52055719
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.26884454
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62198866
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10998557
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06161035
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87253738
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.85499350
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82279268
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.54648731
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53561927
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48659419
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48324237
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47170595
15AR_21909140_ChIP-Seq_LNCAP_Human2.39659001
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37320411
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.35892592
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34422176
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.34138856
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.34122115
21XRN2_22483619_ChIP-Seq_HELA_Human2.33585667
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33525711
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28626240
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28593211
25ZNF274_21170338_ChIP-Seq_K562_Hela2.25372844
26VDR_23849224_ChIP-Seq_CD4+_Human2.22336243
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.20390984
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.16231434
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10981892
30TTF2_22483619_ChIP-Seq_HELA_Human2.06692690
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06150169
32FUS_26573619_Chip-Seq_HEK293_Human2.05256596
33ELK1_19687146_ChIP-ChIP_HELA_Human2.01238175
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00670626
35E2F7_22180533_ChIP-Seq_HELA_Human10.1870918
36FOXP3_21729870_ChIP-Seq_TREG_Human1.97869341
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97112349
38* CIITA_25753668_ChIP-Seq_RAJI_Human1.95918769
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92752503
40DCP1A_22483619_ChIP-Seq_HELA_Human1.89536267
41VDR_22108803_ChIP-Seq_LS180_Human1.86057039
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85149830
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84665307
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82032438
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79318174
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79311782
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76974082
48IGF1R_20145208_ChIP-Seq_DFB_Human1.66007066
49GABP_19822575_ChIP-Seq_HepG2_Human1.65012737
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63859132
51* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62830571
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61005077
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.59581335
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57600322
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55932758
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53710020
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.51737834
58TAF15_26573619_Chip-Seq_HEK293_Human1.51066247
59MYC_22102868_ChIP-Seq_BL_Human1.51021601
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50469752
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49942339
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48901695
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44239196
64P300_19829295_ChIP-Seq_ESCs_Human1.43968608
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40126355
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39944006
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39585071
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39386421
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38683785
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31987357
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31978278
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.31313837
73KDM5A_27292631_Chip-Seq_BREAST_Human1.31036883
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25629251
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25451444
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25161327
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24173203
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23219764
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.18865299
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17724839
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.16511560
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14682251
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.13403377
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.08139631
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06870711
86MYC_18940864_ChIP-ChIP_HL60_Human1.05922253
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05752044
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03340837
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02286428
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01957409
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01144258
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00886861
93IRF1_19129219_ChIP-ChIP_H3396_Human1.00541969
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00470185
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99221675
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99151212
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97661009
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97026818
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96276703
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92622289
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92387531
102TFEB_21752829_ChIP-Seq_HELA_Human0.91098982
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90471578
104* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90049014
105NFE2_27457419_Chip-Seq_LIVER_Mouse0.89858974
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89801486
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89105587
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87873456
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87352697
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86876740
111ER_23166858_ChIP-Seq_MCF-7_Human0.86410204
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86249201
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86243719
114SPI1_23547873_ChIP-Seq_NB4_Human0.85282932
115EWS_26573619_Chip-Seq_HEK293_Human0.85269944
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84520173
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.83893732
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.83766863
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83139144
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83031104
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81986251
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81048369
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.80317215
124CBP_20019798_ChIP-Seq_JUKART_Human0.80123881
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80123881
126NANOG_19829295_ChIP-Seq_ESCs_Human0.77986603
127SOX2_19829295_ChIP-Seq_ESCs_Human0.77986603
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77177915
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.74504294
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.74422841
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73977708
132ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72466443
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.71041812
134VDR_21846776_ChIP-Seq_THP-1_Human0.69784295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41230518
2MP0010094_abnormal_chromosome_stability4.19269389
3MP0008057_abnormal_DNA_replication3.89629381
4MP0003111_abnormal_nucleus_morphology3.64124527
5MP0004957_abnormal_blastocyst_morpholog3.51814552
6MP0003077_abnormal_cell_cycle3.47201617
7MP0008058_abnormal_DNA_repair3.11247341
8MP0008007_abnormal_cellular_replicative2.93636882
9MP0003123_paternal_imprinting2.45218340
10MP0008932_abnormal_embryonic_tissue2.38569352
11MP0002396_abnormal_hematopoietic_system2.36235164
12MP0003718_maternal_effect2.21675469
13MP0000372_irregular_coat_pigmentation2.15339752
14MP0006072_abnormal_retinal_apoptosis2.05569587
15MP0003121_genomic_imprinting2.05413321
16MP0000350_abnormal_cell_proliferation1.97928129
17MP0010030_abnormal_orbit_morphology1.88218704
18MP0000537_abnormal_urethra_morphology1.83805407
19MP0008877_abnormal_DNA_methylation1.79913719
20MP0001730_embryonic_growth_arrest1.77779804
21MP0009053_abnormal_anal_canal1.67376209
22MP0003786_premature_aging1.65922908
23MP0004808_abnormal_hematopoietic_stem1.59234787
24MP0001293_anophthalmia1.57691504
25MP0010352_gastrointestinal_tract_polyps1.56590225
26MP0000490_abnormal_crypts_of1.56396926
27MP0003315_abnormal_perineum_morphology1.54578129
28MP0003941_abnormal_skin_development1.50952598
29MP0001529_abnormal_vocalization1.49762069
30MP0001697_abnormal_embryo_size1.49151918
31MP0003567_abnormal_fetal_cardiomyocyte1.48774131
32MP0001672_abnormal_embryogenesis/_devel1.47216021
33MP0005380_embryogenesis_phenotype1.47216021
34MP0002938_white_spotting1.46567451
35MP0002085_abnormal_embryonic_tissue1.42189891
36MP0005253_abnormal_eye_physiology1.41484929
37MP0006054_spinal_hemorrhage1.40939718
38MP0010307_abnormal_tumor_latency1.39378286
39MP0006292_abnormal_olfactory_placode1.38967522
40MP0002084_abnormal_developmental_patter1.32825118
41MP0003984_embryonic_growth_retardation1.31909112
42MP0003890_abnormal_embryonic-extraembry1.30574100
43MP0002088_abnormal_embryonic_growth/wei1.28573194
44MP0000566_synostosis1.28149873
45MP0004197_abnormal_fetal_growth/weight/1.27095255
46* MP0002080_prenatal_lethality1.25361528
47MP0008789_abnormal_olfactory_epithelium1.24925595
48MP0000313_abnormal_cell_death1.24267853
49MP0001929_abnormal_gametogenesis1.22088665
50MP0002736_abnormal_nociception_after1.21819096
51MP0002009_preneoplasia1.21468057
52MP0002234_abnormal_pharynx_morphology1.17482213
53MP0002086_abnormal_extraembryonic_tissu1.15703830
54MP0000049_abnormal_middle_ear1.13298180
55MP0009379_abnormal_foot_pigmentation1.11918887
56MP0003937_abnormal_limbs/digits/tail_de1.11726367
57MP0002254_reproductive_system_inflammat1.11124613
58MP0003763_abnormal_thymus_physiology1.10115171
59MP0005076_abnormal_cell_differentiation1.09453335
60MP0003787_abnormal_imprinting1.08680924
61MP0003136_yellow_coat_color1.07856278
62MP0001188_hyperpigmentation1.07506224
63MP0002019_abnormal_tumor_incidence1.07346110
64MP0002095_abnormal_skin_pigmentation1.07094391
65MP0003806_abnormal_nucleotide_metabolis1.06369986
66MP0000703_abnormal_thymus_morphology1.05700748
67MP0002210_abnormal_sex_determination1.05273198
68MP0001177_atelectasis1.03941799
69MP0001286_abnormal_eye_development1.02861481
70MP0003122_maternal_imprinting1.00311573
71MP0006035_abnormal_mitochondrial_morpho0.99335496
72MP0004147_increased_porphyrin_level0.99161847
73MP0003880_abnormal_central_pattern0.98849112
74MP0000647_abnormal_sebaceous_gland0.97727251
75MP0003119_abnormal_digestive_system0.97321674
76MP0006036_abnormal_mitochondrial_physio0.97040242
77MP0005391_vision/eye_phenotype0.96664996
78MP0001485_abnormal_pinna_reflex0.95773889
79MP0005075_abnormal_melanosome_morpholog0.94752249
80MP0008995_early_reproductive_senescence0.94470215
81MP0004215_abnormal_myocardial_fiber0.93761063
82MP0005551_abnormal_eye_electrophysiolog0.93497924
83MP0003115_abnormal_respiratory_system0.92978736
84MP0000631_abnormal_neuroendocrine_gland0.92228114
85MP0002132_abnormal_respiratory_system0.91101575
86MP0000516_abnormal_urinary_system0.87624009
87MP0005367_renal/urinary_system_phenotyp0.87624009
88MP0003942_abnormal_urinary_system0.87571783
89MP0002751_abnormal_autonomic_nervous0.86822150
90MP0001145_abnormal_male_reproductive0.86767934
91MP0001119_abnormal_female_reproductive0.86079125
92MP0002111_abnormal_tail_morphology0.86030149
93MP0001764_abnormal_homeostasis0.86012311
94MP0002398_abnormal_bone_marrow0.85875722
95MP0002092_abnormal_eye_morphology0.84577508
96MP0003755_abnormal_palate_morphology0.84014188
97MP0003385_abnormal_body_wall0.83927421
98MP0002282_abnormal_trachea_morphology0.83613421
99MP0002932_abnormal_joint_morphology0.83336310
100MP0000428_abnormal_craniofacial_morphol0.81954961
101MP0009333_abnormal_splenocyte_physiolog0.81683285
102MP0003186_abnormal_redox_activity0.81528800
103MP0005397_hematopoietic_system_phenotyp0.80754639
104MP0001545_abnormal_hematopoietic_system0.80754639
105MP0005395_other_phenotype0.80082990
106MP0009672_abnormal_birth_weight0.79954547
107MP0002160_abnormal_reproductive_system0.79699444
108MP0005394_taste/olfaction_phenotype0.79341749
109MP0005499_abnormal_olfactory_system0.79341749
110MP0000569_abnormal_digit_pigmentation0.79251508
111MP0003943_abnormal_hepatobiliary_system0.79158965
112MP0003698_abnormal_male_reproductive0.79066004
113MP0002102_abnormal_ear_morphology0.78328217
114MP0003195_calcinosis0.78253459
115MP0009703_decreased_birth_body0.78239288
116MP0004133_heterotaxia0.77731056
117MP0005174_abnormal_tail_pigmentation0.77366776
118MP0000432_abnormal_head_morphology0.76665043
119MP0002233_abnormal_nose_morphology0.76623729
120MP0003935_abnormal_craniofacial_develop0.76549931
121MP0000653_abnormal_sex_gland0.75547785
122MP0009250_abnormal_appendicular_skeleto0.74041825
123MP0002722_abnormal_immune_system0.73898922
124MP0005171_absent_coat_pigmentation0.71807996
125MP0008872_abnormal_physiological_respon0.71754458
126MP0002116_abnormal_craniofacial_bone0.70912588
127MP0009697_abnormal_copulation0.70903702
128MP0000427_abnormal_hair_cycle0.70710663
129MP0002697_abnormal_eye_size0.70432593
130MP0005503_abnormal_tendon_morphology0.69548881
131MP0003861_abnormal_nervous_system0.69322293
132MP0002177_abnormal_outer_ear0.68153117
133MP0001324_abnormal_eye_pigmentation0.67913058
134MP0000689_abnormal_spleen_morphology0.67286495
135MP0005389_reproductive_system_phenotype0.67199589
136MP0002006_tumorigenesis0.66501886

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.97971558
2Colon cancer (HP:0003003)3.58878655
3Chromsome breakage (HP:0040012)3.58625813
4Reticulocytopenia (HP:0001896)3.58577156
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35494433
6Abnormality of cells of the erythroid lineage (HP:0012130)3.05696845
7Patellar aplasia (HP:0006443)3.05677418
8Abnormal number of erythroid precursors (HP:0012131)3.01322644
9Medulloblastoma (HP:0002885)2.99912894
10Volvulus (HP:0002580)2.94496736
11Aplasia/Hypoplasia of the patella (HP:0006498)2.90363423
12Meckel diverticulum (HP:0002245)2.90204157
13Abnormal number of incisors (HP:0011064)2.89289311
14Abnormality of chromosome stability (HP:0003220)2.89216735
15Selective tooth agenesis (HP:0001592)2.85675888
16Short 4th metacarpal (HP:0010044)2.85457333
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.85457333
18Abnormality of the preputium (HP:0100587)2.81108544
19Abnormal lung lobation (HP:0002101)2.80303853
20Abnormality of the ileum (HP:0001549)2.79274147
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.71391975
22Small intestinal stenosis (HP:0012848)2.70878212
23Duodenal stenosis (HP:0100867)2.70878212
2411 pairs of ribs (HP:0000878)2.67415372
25Oral leukoplakia (HP:0002745)2.66656307
26Ectopic kidney (HP:0000086)2.62903002
27Pancreatic cysts (HP:0001737)2.62569387
28Aplastic anemia (HP:0001915)2.61902150
29Breast hypoplasia (HP:0003187)2.56101612
30Pancreatic fibrosis (HP:0100732)2.53609589
31Increased nuchal translucency (HP:0010880)2.51571544
32True hermaphroditism (HP:0010459)2.51020990
33Myelodysplasia (HP:0002863)2.50747062
34Glioma (HP:0009733)2.45237600
35Abnormality of midbrain morphology (HP:0002418)2.42570660
36Molar tooth sign on MRI (HP:0002419)2.42570660
37Nephroblastoma (Wilms tumor) (HP:0002667)2.41517394
38Degeneration of anterior horn cells (HP:0002398)2.37295242
39Abnormality of the anterior horn cell (HP:0006802)2.37295242
40Atresia of the external auditory canal (HP:0000413)2.34700194
41Short middle phalanx of the 5th finger (HP:0004220)2.32932387
42Methylmalonic acidemia (HP:0002912)2.30771994
43Proximal placement of thumb (HP:0009623)2.28629574
44Optic nerve coloboma (HP:0000588)2.27907611
45Embryonal renal neoplasm (HP:0011794)2.25024335
46Abnormality of the duodenum (HP:0002246)2.24043028
47Deviation of the thumb (HP:0009603)2.17564342
48Impulsivity (HP:0100710)2.16600690
49Absent thumb (HP:0009777)2.13193669
50Acute necrotizing encephalopathy (HP:0006965)2.10913452
51Hyperglycinemia (HP:0002154)2.10017582
52Sloping forehead (HP:0000340)2.10014035
53Abnormality of methionine metabolism (HP:0010901)2.09871029
54Acute encephalopathy (HP:0006846)2.08784016
55Abnormality of the astrocytes (HP:0100707)2.08468621
56Astrocytoma (HP:0009592)2.08468621
57Premature graying of hair (HP:0002216)2.07917644
58Absent radius (HP:0003974)2.07421952
59Small hand (HP:0200055)2.07419006
60Pallor (HP:0000980)2.06541143
61Neoplasm of the pancreas (HP:0002894)2.06369841
62Bifid tongue (HP:0010297)2.05697805
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05335610
64Pancreatic islet-cell hyperplasia (HP:0004510)2.04837603
65Aplasia/Hypoplasia of the sternum (HP:0006714)2.02640016
66Abnormality of the carotid arteries (HP:0005344)2.02190178
67Supernumerary spleens (HP:0009799)1.98117558
68Triphalangeal thumb (HP:0001199)1.97769538
69Ependymoma (HP:0002888)1.97552822
70Bone marrow hypocellularity (HP:0005528)1.97074721
71Carpal bone hypoplasia (HP:0001498)1.95748984
72Absent forearm bone (HP:0003953)1.95404756
73Aplasia involving forearm bones (HP:0009822)1.95404756
74Short thumb (HP:0009778)1.95349050
75Nephronophthisis (HP:0000090)1.92674179
76Tracheoesophageal fistula (HP:0002575)1.92263427
77Increased CSF lactate (HP:0002490)1.92157826
78Progressive macrocephaly (HP:0004481)1.92054102
79Abnormality of the labia minora (HP:0012880)1.91931590
80Abnormality of serum amino acid levels (HP:0003112)1.90877651
81Hypoplastic pelvis (HP:0008839)1.90000467
82Abnormality of the incisor (HP:0000676)1.89462793
83Horseshoe kidney (HP:0000085)1.89281811
84Rhabdomyosarcoma (HP:0002859)1.88513875
85Abnormality of the renal collecting system (HP:0004742)1.88213175
86Increased hepatocellular lipid droplets (HP:0006565)1.87544248
87Neoplasm of the adrenal cortex (HP:0100641)1.87364810
88Neoplasm of the colon (HP:0100273)1.86160614
89Agnosia (HP:0010524)1.85602762
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.85602722
91Rough bone trabeculation (HP:0100670)1.85248223
92B lymphocytopenia (HP:0010976)1.85059416
93Dandy-Walker malformation (HP:0001305)1.84468669
94Macrocytic anemia (HP:0001972)1.84385045
95Abnormality of the 4th metacarpal (HP:0010012)1.83625907
96Oligodactyly (hands) (HP:0001180)1.81524641
97Facial cleft (HP:0002006)1.80990991
98Renal duplication (HP:0000075)1.80662763
99Deep philtrum (HP:0002002)1.79948619
100Clubbing of toes (HP:0100760)1.75940053
101Long eyelashes (HP:0000527)1.75580745
102Gastrointestinal atresia (HP:0002589)1.74782180
103Lipid accumulation in hepatocytes (HP:0006561)1.74601087
104Methylmalonic aciduria (HP:0012120)1.73074075
105Abnormality of the fingertips (HP:0001211)1.72004196
106Abnormality of the pons (HP:0007361)1.71846610
107Cortical dysplasia (HP:0002539)1.71659501
108Neoplasm of the adrenal gland (HP:0100631)1.71207415
109Acute myeloid leukemia (HP:0004808)1.70727076
110Renal cortical cysts (HP:0000803)1.70558781
111Mitochondrial inheritance (HP:0001427)1.70218112
112Combined immunodeficiency (HP:0005387)1.70026399
113Duplicated collecting system (HP:0000081)1.69945731
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.69313221
115Pendular nystagmus (HP:0012043)1.69197573
116Syringomyelia (HP:0003396)1.67936885
117Spinal cord lesions (HP:0100561)1.67936885
118Abnormality of glycine metabolism (HP:0010895)1.67392297
119Abnormality of serine family amino acid metabolism (HP:0010894)1.67392297
120Abnormal mitochondria in muscle tissue (HP:0008316)1.67164788
121Basal cell carcinoma (HP:0002671)1.67140324
122Astigmatism (HP:0000483)1.66885102
123Abnormality of B cell number (HP:0010975)1.66584011
124Lymphoma (HP:0002665)1.66454862
125Stenosis of the external auditory canal (HP:0000402)1.66363627
126High anterior hairline (HP:0009890)1.66227738
127Median cleft lip (HP:0000161)1.65896950
128Postaxial foot polydactyly (HP:0001830)1.65890630
129Hypoplasia of the pons (HP:0012110)1.65571238
130Gonadotropin excess (HP:0000837)1.65534783
131Abnormal hair whorl (HP:0010721)1.65494446
132Ovarian neoplasm (HP:0100615)1.64000250
133Cleft eyelid (HP:0000625)1.63477874
134Amaurosis fugax (HP:0100576)1.63143101
135Type I transferrin isoform profile (HP:0003642)1.62697974
136Hypoplasia of the radius (HP:0002984)1.62293145
137Cellular immunodeficiency (HP:0005374)1.62141037
138Septo-optic dysplasia (HP:0100842)1.62018274
139Intestinal atresia (HP:0011100)1.61367977
140Renal hypoplasia (HP:0000089)1.60955685
141Oligohydramnios (HP:0001562)1.60894053
142Cerebral edema (HP:0002181)1.60135569
143Prominent nose (HP:0000448)1.59450225
144Sclerocornea (HP:0000647)1.59208349
145Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.58832770
146IgM deficiency (HP:0002850)1.58236963
147Abnormality of the renal medulla (HP:0100957)1.57902693
148Anencephaly (HP:0002323)1.57293205
149Preaxial hand polydactyly (HP:0001177)1.57228439
150Short tibia (HP:0005736)1.57087822
151Abnormality of the parietal bone (HP:0002696)1.56684271
152Slender long bone (HP:0003100)1.56338887
153Microretrognathia (HP:0000308)1.56238346
154Thrombocytosis (HP:0001894)1.56120112
155Abnormality of DNA repair (HP:0003254)1.55834120
156Missing ribs (HP:0000921)1.55790790
157Cafe-au-lait spot (HP:0000957)1.53470336
158Neoplasm of the oral cavity (HP:0100649)1.53177276

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.32404091
2WEE13.79494403
3BUB13.73103060
4SRPK13.34775511
5MKNK13.30240435
6PASK2.78551236
7EIF2AK12.69541846
8TRIM282.66378200
9NEK22.55396427
10WNK32.53400104
11MKNK22.36577373
12VRK12.35713688
13BRSK22.27027728
14ACVR1B2.22801916
15DYRK32.13392493
16BMPR1B2.04535341
17PLK42.01034075
18PLK31.95567891
19TSSK61.94850106
20TTK1.94565821
21ATR1.93860853
22FRK1.92355508
23CCNB11.90472286
24VRK21.87087297
25ERBB31.84537966
26RPS6KA41.82745930
27PLK11.81440225
28STK161.80045599
29CDK71.74875853
30AURKB1.73928345
31TNIK1.72663770
32TGFBR11.71154726
33NEK11.67145580
34EIF2AK31.59216211
35MAP4K21.56193371
36ZAK1.51006304
37PNCK1.50841281
38TAF11.43707802
39BRSK11.39850857
40RPS6KB21.35703073
41CHEK21.31050319
42TLK11.26714673
43CDK81.25915615
44NME21.23178831
45CHEK11.17390243
46PAK41.14450236
47BRD41.11663689
48CDK121.11265312
49CDK41.10345683
50CLK11.08769154
51PLK21.08316666
52STK41.04268250
53YES11.04248528
54EIF2AK21.01503267
55ATM0.99508622
56MAP3K100.98322796
57AURKA0.95179010
58SIK30.92036236
59CSNK1G10.90268395
60CDK60.86474373
61CDK20.84393629
62MAP3K80.82391339
63STK390.81500162
64CASK0.81089076
65STK100.81014182
66MELK0.74857065
67CDK10.73486133
68OXSR10.73341667
69TESK20.72189625
70PIM10.71836887
71CSNK1G20.70833579
72CSNK2A10.70525662
73MAP3K40.67503574
74FLT30.66600319
75CSNK2A20.63841753
76STK38L0.63838051
77PBK0.62593808
78GRK10.60505590
79CHUK0.59179138
80SCYL20.58619167
81INSRR0.56985555
82NEK90.56909844
83PDK20.56759846
84BTK0.56309883
85TEC0.54694804
86RPS6KA50.53631140
87EEF2K0.52119813
88EPHA40.51908560
89NME10.47731387
90TESK10.46698678
91STK30.46691051
92DYRK20.45763894
93EPHB20.41312097
94NLK0.38934293
95MST40.38558964
96IRAK40.38269243
97PKN10.37644622
98PAK30.36886857
99PRKDC0.36623090
100MINK10.36437283
101ADRBK20.35844212
102TAOK20.35460834
103FGFR20.35074980
104MAPK140.34658590
105AKT10.34483480
106CDK30.33761772
107MARK30.32936398
108LATS10.32502397
109ALK0.31948109
110NUAK10.31817371
111AKT30.31184677
112CDK90.30825379
113ERBB40.30779046
114LIMK10.30703594
115CSNK1E0.29611529
116AKT20.29134441
117MAP4K10.29067148
118RPS6KB10.27648259
119EPHA20.26871032
120KIT0.26820728
121PRKCI0.26460899
122ERBB20.26408093
123PRKCG0.26108810
124MAPK130.26072789
125DYRK1B0.25567381
126PAK10.25394538
127MAP3K120.25172758
128PRKCE0.24699371
129CSNK1G30.24668890
130CSNK1A1L0.24564395
131WNK40.24342629
132BCR0.23925461
133RPS6KC10.23062258
134RPS6KL10.23062258
135FER0.22989034
136MAPKAPK20.22866494
137FGFR10.22526819

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02104247
2Mismatch repair_Homo sapiens_hsa034304.40355491
3* Spliceosome_Homo sapiens_hsa030403.60429484
4Base excision repair_Homo sapiens_hsa034103.27891921
5Homologous recombination_Homo sapiens_hsa034403.17088375
6Ribosome_Homo sapiens_hsa030103.10065632
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07928031
8Cell cycle_Homo sapiens_hsa041102.96317628
9RNA transport_Homo sapiens_hsa030132.87625796
10Nucleotide excision repair_Homo sapiens_hsa034202.85594608
11RNA polymerase_Homo sapiens_hsa030202.63427592
12Proteasome_Homo sapiens_hsa030502.57310667
13Fanconi anemia pathway_Homo sapiens_hsa034602.48186173
14Non-homologous end-joining_Homo sapiens_hsa034502.38170011
15Pyrimidine metabolism_Homo sapiens_hsa002402.21186850
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17670650
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15983765
18One carbon pool by folate_Homo sapiens_hsa006702.14517401
19RNA degradation_Homo sapiens_hsa030182.14017542
20mRNA surveillance pathway_Homo sapiens_hsa030151.96273595
21Propanoate metabolism_Homo sapiens_hsa006401.91036754
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89838605
23Basal transcription factors_Homo sapiens_hsa030221.88195924
24p53 signaling pathway_Homo sapiens_hsa041151.65837441
25Steroid biosynthesis_Homo sapiens_hsa001001.64191193
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.53321299
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38186224
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29098423
29Systemic lupus erythematosus_Homo sapiens_hsa053221.29009523
30Oxidative phosphorylation_Homo sapiens_hsa001901.26555318
31Epstein-Barr virus infection_Homo sapiens_hsa051691.26522010
32Parkinsons disease_Homo sapiens_hsa050121.23573823
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22902314
34Purine metabolism_Homo sapiens_hsa002301.19953199
35* Herpes simplex infection_Homo sapiens_hsa051681.14813046
36Pyruvate metabolism_Homo sapiens_hsa006201.10443222
37Protein export_Homo sapiens_hsa030601.08331802
38Viral carcinogenesis_Homo sapiens_hsa052031.05681081
39Antigen processing and presentation_Homo sapiens_hsa046121.03882471
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03297503
41HTLV-I infection_Homo sapiens_hsa051661.02204782
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01232933
43Butanoate metabolism_Homo sapiens_hsa006501.01206452
44Fatty acid elongation_Homo sapiens_hsa000620.97580313
45Oocyte meiosis_Homo sapiens_hsa041140.93834560
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90915021
47MicroRNAs in cancer_Homo sapiens_hsa052060.89762091
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89567629
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89364836
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88707293
51Basal cell carcinoma_Homo sapiens_hsa052170.87998203
52Vitamin B6 metabolism_Homo sapiens_hsa007500.87948379
53Phototransduction_Homo sapiens_hsa047440.82654590
54Small cell lung cancer_Homo sapiens_hsa052220.82593251
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80414281
56TGF-beta signaling pathway_Homo sapiens_hsa043500.79098908
57Primary immunodeficiency_Homo sapiens_hsa053400.78135501
58Glutathione metabolism_Homo sapiens_hsa004800.77523349
59Colorectal cancer_Homo sapiens_hsa052100.77251439
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76508436
61Thyroid cancer_Homo sapiens_hsa052160.73047487
62Legionellosis_Homo sapiens_hsa051340.72272757
63Alcoholism_Homo sapiens_hsa050340.68644267
64Notch signaling pathway_Homo sapiens_hsa043300.68162749
65N-Glycan biosynthesis_Homo sapiens_hsa005100.65884722
66Hippo signaling pathway_Homo sapiens_hsa043900.64731378
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63625623
68Hepatitis B_Homo sapiens_hsa051610.62583897
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60890891
70Caffeine metabolism_Homo sapiens_hsa002320.56139394
71Hedgehog signaling pathway_Homo sapiens_hsa043400.55773841
72Measles_Homo sapiens_hsa051620.55465148
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.54164083
74Chronic myeloid leukemia_Homo sapiens_hsa052200.53737890
75Tryptophan metabolism_Homo sapiens_hsa003800.53313896
76Viral myocarditis_Homo sapiens_hsa054160.50790043
77Alzheimers disease_Homo sapiens_hsa050100.50731734
78Metabolic pathways_Homo sapiens_hsa011000.50359935
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50165702
80Nitrogen metabolism_Homo sapiens_hsa009100.49879584
81Apoptosis_Homo sapiens_hsa042100.49592262
82Pathways in cancer_Homo sapiens_hsa052000.49026757
83Prostate cancer_Homo sapiens_hsa052150.48970847
84Hematopoietic cell lineage_Homo sapiens_hsa046400.48365887
85Fatty acid metabolism_Homo sapiens_hsa012120.46160309
86Wnt signaling pathway_Homo sapiens_hsa043100.45596392
87Adherens junction_Homo sapiens_hsa045200.44905988
88Peroxisome_Homo sapiens_hsa041460.43424552
89Carbon metabolism_Homo sapiens_hsa012000.42597420
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41434789
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40766110
92beta-Alanine metabolism_Homo sapiens_hsa004100.39896038
93Fatty acid degradation_Homo sapiens_hsa000710.39647497
94Influenza A_Homo sapiens_hsa051640.38331785
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37861047
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37537993
97Biosynthesis of amino acids_Homo sapiens_hsa012300.37352208
98Shigellosis_Homo sapiens_hsa051310.36839134
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.34564295
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33635048
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.32844892
102Regulation of autophagy_Homo sapiens_hsa041400.32208827
103Selenocompound metabolism_Homo sapiens_hsa004500.32060675
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31745505
105Huntingtons disease_Homo sapiens_hsa050160.31517571
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31482891
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30949954
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29470531
109Pancreatic cancer_Homo sapiens_hsa052120.28449698
110Vitamin digestion and absorption_Homo sapiens_hsa049770.28172118
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28058657
112Non-small cell lung cancer_Homo sapiens_hsa052230.27927414
113Ether lipid metabolism_Homo sapiens_hsa005650.27006773
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25897144
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.25523538
116Endometrial cancer_Homo sapiens_hsa052130.24953097
117Retinol metabolism_Homo sapiens_hsa008300.24796566
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24435528
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24083774
120Linoleic acid metabolism_Homo sapiens_hsa005910.23986543
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23740489
122Melanoma_Homo sapiens_hsa052180.22009877
123Asthma_Homo sapiens_hsa053100.21660304
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21316162
125Allograft rejection_Homo sapiens_hsa053300.21313115
126Sulfur metabolism_Homo sapiens_hsa009200.20662941
127FoxO signaling pathway_Homo sapiens_hsa040680.20596395
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20513555
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.20451375
130Chemical carcinogenesis_Homo sapiens_hsa052040.20384759
131Bladder cancer_Homo sapiens_hsa052190.20017226
132T cell receptor signaling pathway_Homo sapiens_hsa046600.19499400
133Leishmaniasis_Homo sapiens_hsa051400.19007793
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18799076
135Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18352562
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.17858635
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.17429716
138Acute myeloid leukemia_Homo sapiens_hsa052210.17397922
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17246872
140HIF-1 signaling pathway_Homo sapiens_hsa040660.17140456
141B cell receptor signaling pathway_Homo sapiens_hsa046620.16598007
142Proteoglycans in cancer_Homo sapiens_hsa052050.16491975
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16069555
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.15614109
145Folate biosynthesis_Homo sapiens_hsa007900.15247746
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14270219
147Autoimmune thyroid disease_Homo sapiens_hsa053200.14206576
148Lysine degradation_Homo sapiens_hsa003100.13694677
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11845627
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11721219
151Renin-angiotensin system_Homo sapiens_hsa046140.11540402

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