SRSF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.15996674
2DNA deamination (GO:0045006)6.16443319
3transcription from mitochondrial promoter (GO:0006390)6.12239138
4replication fork processing (GO:0031297)6.12041637
5proline metabolic process (GO:0006560)5.95788557
6embryonic process involved in female pregnancy (GO:0060136)5.76462561
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.52179622
8positive regulation of protein homooligomerization (GO:0032464)5.04673790
9establishment of apical/basal cell polarity (GO:0035089)4.94857330
10somatic diversification of immune receptors via somatic mutation (GO:0002566)4.88453999
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.88453999
12telomere maintenance via semi-conservative replication (GO:0032201)4.87890795
13negative regulation of histone methylation (GO:0031061)4.86914608
14nuclear pore complex assembly (GO:0051292)4.81614640
15mitotic G1 DNA damage checkpoint (GO:0031571)4.81504849
16regulation of DNA endoreduplication (GO:0032875)4.70847167
17oxidative demethylation (GO:0070989)4.69016094
18regulation of integrin activation (GO:0033623)4.64769308
19regulation of translational fidelity (GO:0006450)4.63340813
20dosage compensation (GO:0007549)4.57968751
21mitochondrial DNA metabolic process (GO:0032042)4.57168103
22DNA strand elongation involved in DNA replication (GO:0006271)4.46343084
23regulation of protein homooligomerization (GO:0032462)4.42536076
24viral mRNA export from host cell nucleus (GO:0046784)4.41174006
25DNA strand renaturation (GO:0000733)4.37886179
26base-excision repair (GO:0006284)4.29366536
27regulation of chromatin binding (GO:0035561)4.25978179
28poly(A)+ mRNA export from nucleus (GO:0016973)4.25468332
29spliceosomal tri-snRNP complex assembly (GO:0000244)4.23799024
30mitotic G1/S transition checkpoint (GO:0044819)4.22813861
31DNA strand elongation (GO:0022616)4.22415514
32mRNA splice site selection (GO:0006376)4.19732700
33formation of translation preinitiation complex (GO:0001731)4.18828961
34G1 DNA damage checkpoint (GO:0044783)4.17401607
35establishment or maintenance of monopolar cell polarity (GO:0061339)4.15373156
36establishment of monopolar cell polarity (GO:0061162)4.15373156
37nucleotide-excision repair, DNA gap filling (GO:0006297)4.14721332
38nuclear pore organization (GO:0006999)4.13625137
39mRNA cleavage (GO:0006379)4.08268989
40DNA topological change (GO:0006265)4.02628582
41telomere maintenance via recombination (GO:0000722)3.99257557
42negative regulation of cell cycle arrest (GO:0071157)3.93680259
43mitotic chromosome condensation (GO:0007076)3.91307097
44regulation of RNA export from nucleus (GO:0046831)3.87613980
45histone H3-K4 trimethylation (GO:0080182)3.84857340
46histone H4-K12 acetylation (GO:0043983)3.83785039
47regulation of sister chromatid cohesion (GO:0007063)3.82446908
48positive regulation by host of viral transcription (GO:0043923)3.81435779
49mitotic sister chromatid cohesion (GO:0007064)3.77304801
50DNA unwinding involved in DNA replication (GO:0006268)3.77035438
51monoubiquitinated protein deubiquitination (GO:0035520)3.76970573
52negative regulation of JAK-STAT cascade (GO:0046426)3.70012439
53glucocorticoid receptor signaling pathway (GO:0042921)3.68479882
54alternative mRNA splicing, via spliceosome (GO:0000380)3.64997765
55interkinetic nuclear migration (GO:0022027)3.61782533
56negative regulation of erythrocyte differentiation (GO:0045647)3.60789594
57mitotic recombination (GO:0006312)3.60379435
58* negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.59782108
59embryonic placenta development (GO:0001892)3.59427778
60cytoplasmic mRNA processing body assembly (GO:0033962)3.57657573
61regulation of DNA damage checkpoint (GO:2000001)3.54523614
62pore complex assembly (GO:0046931)3.51524013
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51433109
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51433109
65positive regulation of mitotic sister chromatid separation (GO:1901970)3.51433109
66regulation of histone H3-K9 methylation (GO:0051570)3.49493285
67histone H3-K4 methylation (GO:0051568)3.49284199
68intracellular estrogen receptor signaling pathway (GO:0030520)3.47406090
69regulation of histone H3-K4 methylation (GO:0051569)3.43570283
70kinetochore assembly (GO:0051382)3.41907306
71telomere maintenance via telomere lengthening (GO:0010833)3.41760124
72meiotic chromosome segregation (GO:0045132)3.41238228
73mitotic sister chromatid segregation (GO:0000070)3.41156317
74regulation of histone H3-K27 methylation (GO:0061085)3.40658508
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.36140563
76* negative regulation of mRNA metabolic process (GO:1903312)3.35198789
773-UTR-mediated mRNA stabilization (GO:0070935)3.34289560
78trophectodermal cell differentiation (GO:0001829)3.32314022
79* termination of RNA polymerase II transcription (GO:0006369)3.31314172
80cellular response to zinc ion (GO:0071294)3.30721012
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29071805
82pre-miRNA processing (GO:0031054)3.28629696
83non-recombinational repair (GO:0000726)3.25875807
84double-strand break repair via nonhomologous end joining (GO:0006303)3.25875807
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.24556806
86regulation of double-strand break repair (GO:2000779)3.23230578
87positive regulation of RNA splicing (GO:0033120)3.22400538
88regulation of histone methylation (GO:0031060)3.22297138
89DNA integration (GO:0015074)3.21810927
90positive regulation of chromosome segregation (GO:0051984)3.20354133
91apoptotic process involved in morphogenesis (GO:0060561)3.20055179
92RNA stabilization (GO:0043489)3.19948477
93mRNA stabilization (GO:0048255)3.19948477
94kinetochore organization (GO:0051383)3.18909670
95histone lysine demethylation (GO:0070076)3.15135399
96base-excision repair, AP site formation (GO:0006285)3.13168087
97positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.13127014
98sister chromatid segregation (GO:0000819)3.12177057
99glutamine family amino acid biosynthetic process (GO:0009084)3.11626658
100negative regulation of protein oligomerization (GO:0032460)3.11617726
101DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.10800467
102* negative regulation of RNA splicing (GO:0033119)3.09197487
103mitochondrial RNA metabolic process (GO:0000959)3.08543693
104* negative regulation of mRNA processing (GO:0050686)3.06732580
105nodal signaling pathway (GO:0038092)3.04581423
106histone demethylation (GO:0016577)3.03619861
107histone H3-K36 demethylation (GO:0070544)3.00848227
108positive regulation of protein oligomerization (GO:0032461)3.00595321
109growth hormone receptor signaling pathway (GO:0060396)3.00239043
110DNA duplex unwinding (GO:0032508)3.00070769
111cellular anion homeostasis (GO:0030002)2.99751285
112histone H4-K16 acetylation (GO:0043984)2.99437105
113negative regulation of histone modification (GO:0031057)2.99146057
114histone H3-K9 methylation (GO:0051567)2.98528448
115DNA geometric change (GO:0032392)2.97587574
116protein-DNA complex disassembly (GO:0032986)2.97337542
117nucleosome disassembly (GO:0006337)2.97337542
118DNA ligation (GO:0006266)2.96768390
119histone lysine methylation (GO:0034968)2.96698619
120mucosal-associated lymphoid tissue development (GO:0048537)2.96656296
121Peyers patch development (GO:0048541)2.96656296
122sister chromatid cohesion (GO:0007062)2.95953020
123anatomical structure regression (GO:0060033)2.95667264
124response to UV-C (GO:0010225)2.95546488
125regulation of NFAT protein import into nucleus (GO:0051532)2.94658360
126protein localization to kinetochore (GO:0034501)2.94572907
127regulation of nucleobase-containing compound transport (GO:0032239)2.94352364
128DNA demethylation (GO:0080111)2.93852448
129heterochromatin organization (GO:0070828)2.93616113
130DNA replication initiation (GO:0006270)2.92433832
131peptidyl-lysine trimethylation (GO:0018023)2.92421939
132cell proliferation in forebrain (GO:0021846)2.91850266
133negative regulation of fatty acid biosynthetic process (GO:0045717)2.91230111
134histone H3-K9 demethylation (GO:0033169)2.89392428
135modulation by host of symbiont transcription (GO:0052472)2.89073974
136modulation by host of viral transcription (GO:0043921)2.89073974
137negative regulation of translation, ncRNA-mediated (GO:0040033)2.88359648
138regulation of translation, ncRNA-mediated (GO:0045974)2.88359648
139negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88359648
140resolution of meiotic recombination intermediates (GO:0000712)2.88305987
141negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87653719
142DNA damage response, signal transduction resulting in transcription (GO:0042772)2.86595634
143face development (GO:0060324)2.84466140
144negative regulation of chromatin modification (GO:1903309)2.84152887
145regulation of protein oligomerization (GO:0032459)2.84130912
146corticosteroid receptor signaling pathway (GO:0031958)2.83503011
147embryonic camera-type eye development (GO:0031076)2.82294115
148mitotic nuclear envelope disassembly (GO:0007077)2.81653604
149V(D)J recombination (GO:0033151)2.81321648
150convergent extension (GO:0060026)2.80564722
151* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80475115
152* mRNA splicing, via spliceosome (GO:0000398)2.80475115
153negative thymic T cell selection (GO:0045060)2.80224176
154histone H3-K9 modification (GO:0061647)2.78859328
155regulation of gene silencing by RNA (GO:0060966)2.76969182
156regulation of posttranscriptional gene silencing (GO:0060147)2.76969182
157regulation of gene silencing by miRNA (GO:0060964)2.76969182
158peptidyl-lysine methylation (GO:0018022)2.76754838
159DNA double-strand break processing (GO:0000729)2.75933225
160negative regulation of gene expression, epigenetic (GO:0045814)2.75323464
161* RNA splicing, via transesterification reactions (GO:0000375)2.74370499
162DNA replication checkpoint (GO:0000076)2.73839734
163snRNA transcription (GO:0009301)2.72015644
164positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.70698497
165negative T cell selection (GO:0043383)2.70528271
166* mRNA transport (GO:0051028)2.70453733
167cellular response to virus (GO:0098586)2.66299213
168cellular response to growth hormone stimulus (GO:0071378)2.63795693
169stress granule assembly (GO:0034063)2.63232381
170regulation of mRNA stability (GO:0043488)2.62669177
171* mRNA export from nucleus (GO:0006406)2.60816962
172modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.59633562
173protein dealkylation (GO:0008214)2.58741184
174protein demethylation (GO:0006482)2.58741184
175definitive hemopoiesis (GO:0060216)2.58728697
176DNA conformation change (GO:0071103)2.58689191
177histone deubiquitination (GO:0016578)2.58543565
178response to muramyl dipeptide (GO:0032495)2.57921232
179activated T cell proliferation (GO:0050798)2.57655038
180regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.57435310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.67948086
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.41419373
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04960490
4MYC_22102868_ChIP-Seq_BL_Human2.97528423
5VDR_21846776_ChIP-Seq_THP-1_Human2.95197505
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.95162679
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.88286415
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55291681
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.48979481
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.47211263
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40232958
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27664429
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25682214
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21245650
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10230696
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05404976
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01624809
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91428043
19MYB_26560356_Chip-Seq_TH1_Human1.86591743
20LXR_22292898_ChIP-Seq_THP-1_Human1.85622200
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84557532
22SCL_19346495_ChIP-Seq_HPC-7_Human1.77782118
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77182289
24MYB_26560356_Chip-Seq_TH2_Human1.73571467
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73193808
26NCOR1_26117541_ChIP-Seq_K562_Human1.70846501
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69685816
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69573498
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69573498
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69573498
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65392673
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.64426404
33KDM2B_26808549_Chip-Seq_DND41_Human1.64224732
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62334493
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61815002
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60577139
37TCF7_22412390_ChIP-Seq_EML_Mouse1.58807827
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57435207
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54925078
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54503436
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53966039
42NANOG_21062744_ChIP-ChIP_HESCs_Human1.52683729
43XRN2_22483619_ChIP-Seq_HELA_Human1.52621434
44POU5F1_16518401_ChIP-PET_MESCs_Mouse1.49440128
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.48593006
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48180036
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44668456
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.44441031
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43618690
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43453642
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43303283
52CHD1_26751641_Chip-Seq_LNCaP_Human1.42600745
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.40192400
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40112654
55IRF1_19129219_ChIP-ChIP_H3396_Human1.39917575
56RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39034657
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38950035
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38771804
59ZNF263_19887448_ChIP-Seq_K562_Human1.37445983
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36924261
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36730604
62FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36360568
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36337261
64KDM5A_27292631_Chip-Seq_BREAST_Human1.35522630
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35350593
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35067172
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.34080902
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33830936
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33376430
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32413132
71RACK7_27058665_Chip-Seq_MCF-7_Human1.32227095
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31678233
73TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30791674
74GABP_19822575_ChIP-Seq_HepG2_Human1.29012564
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28917629
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28776886
77MAF_26560356_Chip-Seq_TH1_Human1.28147220
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27486490
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27346703
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26221485
81TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25672862
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25662054
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.24943127
84RUNX_20019798_ChIP-Seq_JUKART_Human1.24825329
85UTX_26944678_Chip-Seq_JUKART_Human1.24765783
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24535441
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24398752
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24286646
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23694241
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23145660
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23119552
92JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21314791
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20473650
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20118211
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20061625
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.19735461
97* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19669560
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19654454
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.19352623
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.19282358
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18794113
102VDR_24763502_ChIP-Seq_THP-1_Human1.16866722
103TTF2_22483619_ChIP-Seq_HELA_Human1.15640193
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15365704
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14416174
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14330023
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13264468
108CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13151365
109MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12987856
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11081948
111CIITA_25753668_ChIP-Seq_RAJI_Human1.08666480
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08478122
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08435035
114* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08296411
115MAF_26560356_Chip-Seq_TH2_Human1.07923345
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07636627
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07629397
118P68_20966046_ChIP-Seq_HELA_Human1.07555501
119POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07449842
120NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06638938
121KDM2B_26808549_Chip-Seq_JURKAT_Human1.06284239
122DCP1A_22483619_ChIP-Seq_HELA_Human1.06256520
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05550682
124CREB1_26743006_Chip-Seq_LNCaP_Human1.04426137
125CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04031843
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03649867
127PHF8_20622854_ChIP-Seq_HELA_Human1.03053072
128IRF8_22096565_ChIP-ChIP_GC-B_Human1.02182887
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01745794
130ETS1_21867929_ChIP-Seq_TH2_Mouse1.01688428
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00692006
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00445011
133GATA1_19941826_ChIP-Seq_K562_Human1.00391874
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00007977
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99962057
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99706501
137ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98637945
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95603308
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94167960
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93938382
141GATA3_27048872_Chip-Seq_THYMUS_Human0.91454049
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89515903
143RUNX1_22412390_ChIP-Seq_EML_Mouse0.89242289
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88165492
145FOXP3_21729870_ChIP-Seq_TREG_Human0.87022477
146SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84154700
147VDR_23849224_ChIP-Seq_CD4+_Human0.82759887
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82723239
149FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82313753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.79122772
2MP0009278_abnormal_bone_marrow4.24524080
3MP0010030_abnormal_orbit_morphology3.49324667
4MP0010094_abnormal_chromosome_stability3.31534272
5MP0003111_abnormal_nucleus_morphology2.74817866
6MP0006292_abnormal_olfactory_placode2.73292434
7MP0004185_abnormal_adipocyte_glucose2.71732464
8MP0003646_muscle_fatigue2.68172222
9MP0004957_abnormal_blastocyst_morpholog2.59589142
10MP0001545_abnormal_hematopoietic_system2.57410109
11MP0005397_hematopoietic_system_phenotyp2.57410109
12MP0004233_abnormal_muscle_weight2.57007742
13MP0001873_stomach_inflammation2.43060784
14MP0003693_abnormal_embryo_hatching2.40302934
15MP0003077_abnormal_cell_cycle2.27975178
16MP0010352_gastrointestinal_tract_polyps2.26590479
17MP0002653_abnormal_ependyma_morphology2.22855632
18MP0005076_abnormal_cell_differentiation2.15867068
19MP0008995_early_reproductive_senescence2.13840114
20MP0008058_abnormal_DNA_repair2.13372401
21MP0005666_abnormal_adipose_tissue2.01621212
22MP0002396_abnormal_hematopoietic_system1.96968688
23MP0003890_abnormal_embryonic-extraembry1.94917330
24MP0002009_preneoplasia1.92416460
25MP0000490_abnormal_crypts_of1.85145779
26MP0000049_abnormal_middle_ear1.83842029
27MP0005174_abnormal_tail_pigmentation1.81958710
28MP0002084_abnormal_developmental_patter1.81913900
29MP0002086_abnormal_extraembryonic_tissu1.80906921
30MP0001697_abnormal_embryo_size1.79809670
31MP0003119_abnormal_digestive_system1.79367726
32MP0004130_abnormal_muscle_cell1.78175396
33MP0000678_abnormal_parathyroid_gland1.77220603
34MP0008877_abnormal_DNA_methylation1.74631694
35MP0001730_embryonic_growth_arrest1.71814311
36MP0002085_abnormal_embryonic_tissue1.69689989
37MP0000350_abnormal_cell_proliferation1.68841002
38MP0004197_abnormal_fetal_growth/weight/1.68323901
39MP0003283_abnormal_digestive_organ1.67041747
40MP0005171_absent_coat_pigmentation1.65362807
41MP0008961_abnormal_basal_metabolism1.64278135
42MP0003786_premature_aging1.63338712
43MP0003567_abnormal_fetal_cardiomyocyte1.62005363
44MP0004133_heterotaxia1.61516514
45MP0006072_abnormal_retinal_apoptosis1.60489655
46MP0001293_anophthalmia1.59665068
47MP0001672_abnormal_embryogenesis/_devel1.56066861
48MP0005380_embryogenesis_phenotype1.56066861
49MP0008932_abnormal_embryonic_tissue1.52778113
50MP0002249_abnormal_larynx_morphology1.50087155
51MP0000631_abnormal_neuroendocrine_gland1.49017507
52MP0001800_abnormal_humoral_immune1.41870591
53MP0001853_heart_inflammation1.40401033
54MP0002234_abnormal_pharynx_morphology1.38718602
55MP0002019_abnormal_tumor_incidence1.38033872
56MP0002080_prenatal_lethality1.37213181
57MP0005671_abnormal_response_to1.37051289
58MP0003984_embryonic_growth_retardation1.34725691
59MP0000685_abnormal_immune_system1.32635004
60MP0002088_abnormal_embryonic_growth/wei1.30906907
61MP0010307_abnormal_tumor_latency1.29289888
62MP0005375_adipose_tissue_phenotype1.26530832
63MP0005075_abnormal_melanosome_morpholog1.24034130
64MP0002282_abnormal_trachea_morphology1.23176837
65MP0001502_abnormal_circadian_rhythm1.20219204
66MP0003453_abnormal_keratinocyte_physiol1.18947540
67MP0005409_darkened_coat_color1.17523818
68MP0000313_abnormal_cell_death1.16109420
69MP0003937_abnormal_limbs/digits/tail_de1.11550048
70MP0004264_abnormal_extraembryonic_tissu1.09690286
71MP0003763_abnormal_thymus_physiology1.09521152
72MP0003938_abnormal_ear_development1.08454444
73MP0003436_decreased_susceptibility_to1.08419211
74MP0000703_abnormal_thymus_morphology1.08211578
75MP0000716_abnormal_immune_system1.08171004
76MP0008007_abnormal_cellular_replicative1.07808097
77MP0003115_abnormal_respiratory_system1.07137393
78MP0009250_abnormal_appendicular_skeleto1.05638689
79MP0000470_abnormal_stomach_morphology1.02524592
80MP0003705_abnormal_hypodermis_morpholog1.02313606
81MP0002932_abnormal_joint_morphology1.00027155
82MP0002111_abnormal_tail_morphology0.99934459
83MP0000689_abnormal_spleen_morphology0.99862811
84MP0004808_abnormal_hematopoietic_stem0.99804823
85MP0003656_abnormal_erythrocyte_physiolo0.99276364
86MP0000428_abnormal_craniofacial_morphol0.99127519
87MP0002138_abnormal_hepatobiliary_system0.98402797
88MP0002398_abnormal_bone_marrow0.98171807
89MP0000371_diluted_coat_color0.97901215
90MP0003172_abnormal_lysosome_physiology0.97082078
91MP0002877_abnormal_melanocyte_morpholog0.96893304
92MP0009333_abnormal_splenocyte_physiolog0.95688502
93MP0000537_abnormal_urethra_morphology0.94480676
94MP0000462_abnormal_digestive_system0.93197224
95MP0002269_muscular_atrophy0.92965955
96MP0003935_abnormal_craniofacial_develop0.92222147
97MP0003221_abnormal_cardiomyocyte_apopto0.92091554
98MP0000579_abnormal_nail_morphology0.91876892
99MP0001849_ear_inflammation0.91267067
100MP0002722_abnormal_immune_system0.90328740
101MP0005646_abnormal_pituitary_gland0.89599061
102MP0002405_respiratory_system_inflammati0.89580038
103MP0002420_abnormal_adaptive_immunity0.89370469
104MP0001819_abnormal_immune_cell0.88650010
105MP0003942_abnormal_urinary_system0.88618645
106MP0003861_abnormal_nervous_system0.86700787
107MP0009053_abnormal_anal_canal0.86321165
108MP0005334_abnormal_fat_pad0.86043128
109MP0000477_abnormal_intestine_morphology0.85449587
110MP0000733_abnormal_muscle_development0.85179572
111MP0002723_abnormal_immune_serum0.81162790
112MP0002452_abnormal_antigen_presenting0.80763005
113MP0010630_abnormal_cardiac_muscle0.79795919
114MP0002166_altered_tumor_susceptibility0.79546673
115MP0005187_abnormal_penis_morphology0.79241193
116MP0000639_abnormal_adrenal_gland0.78416714
117MP0003315_abnormal_perineum_morphology0.77734555
118MP0002114_abnormal_axial_skeleton0.76308211
119MP0002970_abnormal_white_adipose0.76177255
120MP0003943_abnormal_hepatobiliary_system0.75868048
121MP0001145_abnormal_male_reproductive0.75541321
122MP0001915_intracranial_hemorrhage0.74950835
123MP0002075_abnormal_coat/hair_pigmentati0.74739131
124MP0005501_abnormal_skin_physiology0.74728271
125MP0001790_abnormal_immune_system0.73923550
126MP0005387_immune_system_phenotype0.73923550
127MP0008770_decreased_survivor_rate0.73757031
128MP0004145_abnormal_muscle_electrophysio0.73586301
129MP0003948_abnormal_gas_homeostasis0.73515277
130MP0001340_abnormal_eyelid_morphology0.73168070
131MP0002160_abnormal_reproductive_system0.72925939
132MP0000015_abnormal_ear_pigmentation0.71827992
133MP0005000_abnormal_immune_tolerance0.71443861
134MP0005266_abnormal_metabolism0.70751795
135MP0003828_pulmonary_edema0.69743270
136MP0002925_abnormal_cardiovascular_devel0.69434066
137MP0002092_abnormal_eye_morphology0.69240560
138MP0002116_abnormal_craniofacial_bone0.67717757
139MP0001784_abnormal_fluid_regulation0.66656653
140MP0009115_abnormal_fat_cell0.66505247
141MP0005391_vision/eye_phenotype0.65837336
142MP0002089_abnormal_postnatal_growth/wei0.65150834
143MP0002210_abnormal_sex_determination0.64335887
144MP0002429_abnormal_blood_cell0.63588662
145MP0002697_abnormal_eye_size0.62669004

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.80626723
2Facial hemangioma (HP:0000329)4.69864591
3Genetic anticipation (HP:0003743)4.64317149
4Annular pancreas (HP:0001734)4.61661039
5Poikiloderma (HP:0001029)4.33456117
6Pustule (HP:0200039)4.31251406
7Ulnar bowing (HP:0003031)3.99155808
8Concave nail (HP:0001598)3.84049294
9Autoimmune thrombocytopenia (HP:0001973)3.61362084
10Hypochromic microcytic anemia (HP:0004840)3.57400386
11Rectovaginal fistula (HP:0000143)3.50487265
12Rectal fistula (HP:0100590)3.50487265
13Basal cell carcinoma (HP:0002671)3.48657239
14Birth length less than 3rd percentile (HP:0003561)3.47792306
15Intestinal fistula (HP:0100819)3.46875402
16Abnormality of the columella (HP:0009929)3.43703851
17Autoimmune hemolytic anemia (HP:0001890)3.39598035
18Neonatal hypoglycemia (HP:0001998)3.37682357
19Volvulus (HP:0002580)3.37396534
20Turricephaly (HP:0000262)3.28112008
21Selective tooth agenesis (HP:0001592)3.26718429
22Lip pit (HP:0100267)3.24214444
23Increased IgM level (HP:0003496)3.24044146
24Vaginal fistula (HP:0004320)3.22900684
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.22571802
26Patellar aplasia (HP:0006443)3.20517443
27Acute lymphatic leukemia (HP:0006721)3.17538484
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.12956282
29Abnormality of DNA repair (HP:0003254)3.01513714
30Alopecia of scalp (HP:0002293)2.99316259
31Tongue fasciculations (HP:0001308)2.96821832
32Aplasia/Hypoplasia of the patella (HP:0006498)2.93241497
33Squamous cell carcinoma (HP:0002860)2.92314052
34Orthostatic hypotension (HP:0001278)2.89702313
35Intestinal atresia (HP:0011100)2.88585721
36Broad alveolar ridges (HP:0000187)2.85404845
37Absent thumb (HP:0009777)2.83831958
38Chromsome breakage (HP:0040012)2.80541914
39Abnormality of the renal collecting system (HP:0004742)2.80234967
40Long eyelashes (HP:0000527)2.79881291
41Short humerus (HP:0005792)2.78815455
42Ependymoma (HP:0002888)2.77482872
43Neoplasm of the oral cavity (HP:0100649)2.76763895
44Male infertility (HP:0003251)2.76163558
45Sparse lateral eyebrow (HP:0005338)2.75923712
46Absent radius (HP:0003974)2.74979422
47Chin dimple (HP:0010751)2.74100051
48Aplasia/hypoplasia of the humerus (HP:0006507)2.73847143
49Muscle fibrillation (HP:0010546)2.72545457
50Congenital hip dislocation (HP:0001374)2.70291355
51Coronal craniosynostosis (HP:0004440)2.70037272
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.69854353
53Short 4th metacarpal (HP:0010044)2.69854353
54Anteriorly placed anus (HP:0001545)2.69649725
55Polycythemia (HP:0001901)2.67637280
56Abnormality of the astrocytes (HP:0100707)2.66963769
57Astrocytoma (HP:0009592)2.66963769
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.66881432
59Dysmetric saccades (HP:0000641)2.66765328
60Abnormality of the aortic arch (HP:0012303)2.66336504
61Abnormal number of incisors (HP:0011064)2.60224318
62Duplicated collecting system (HP:0000081)2.59580949
63Abnormality of the 4th metacarpal (HP:0010012)2.58726256
64Abnormality of male internal genitalia (HP:0000022)2.58131243
65Premature skin wrinkling (HP:0100678)2.57132263
66Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.56038431
67Vertebral hypoplasia (HP:0008417)2.56038431
68Aplasia involving forearm bones (HP:0009822)2.55563650
69Absent forearm bone (HP:0003953)2.55563650
70Albinism (HP:0001022)2.55204360
71Bowing of the arm (HP:0006488)2.52900606
72Bowed forearm bones (HP:0003956)2.52900606
73Persistence of primary teeth (HP:0006335)2.50632808
74Short chin (HP:0000331)2.48616502
75Hypochromic anemia (HP:0001931)2.47203496
76Cerebral aneurysm (HP:0004944)2.45353421
77Short 5th finger (HP:0009237)2.41476865
78Pancreatic islet-cell hyperplasia (HP:0004510)2.38614458
79Ectopic kidney (HP:0000086)2.34678879
80Reticulocytosis (HP:0001923)2.34355706
81Granulocytopenia (HP:0001913)2.32287044
82High anterior hairline (HP:0009890)2.32192972
83Morphological abnormality of the middle ear (HP:0008609)2.30461868
84Hamartoma (HP:0010566)2.30058144
85Abnormality of the intervertebral disk (HP:0005108)2.29073075
86Premature graying of hair (HP:0002216)2.28725445
872-3 toe syndactyly (HP:0004691)2.28440150
88Large for gestational age (HP:0001520)2.28067706
89Abnormal hemoglobin (HP:0011902)2.25712000
90Abnormality of homocysteine metabolism (HP:0010919)2.24129320
91Homocystinuria (HP:0002156)2.24129320
92Truncal obesity (HP:0001956)2.19942496
93IgA deficiency (HP:0002720)2.15648299
94Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.15233904
95Growth hormone excess (HP:0000845)2.15228454
96Hypotelorism (HP:0000601)2.14241907
97Acute myeloid leukemia (HP:0004808)2.13275841
98Abnormality of cells of the erythroid lineage (HP:0012130)2.11748970
99Abnormality of the proximal phalanges of the hand (HP:0009834)2.11589773
100Obsessive-compulsive behavior (HP:0000722)2.11116014
101Abnormality of reticulocytes (HP:0004312)2.10825724
102Abnormality of the lower motor neuron (HP:0002366)2.10519215
103Abnormality of the nasal septum (HP:0000419)2.09889867
104Progressive cerebellar ataxia (HP:0002073)2.09372862
105Abnormality of the labia minora (HP:0012880)2.08250281
106Vertebral fusion (HP:0002948)2.07990355
107Obstructive sleep apnea (HP:0002870)2.07397398
108Hypotrichosis (HP:0001006)2.06573640
109Capillary hemangiomas (HP:0005306)2.05519704
110Cutis marmorata (HP:0000965)2.04842845
111Colitis (HP:0002583)2.03245929
112Abnormality of chromosome stability (HP:0003220)2.02189787
113Glioma (HP:0009733)2.01603981
114Urinary glycosaminoglycan excretion (HP:0003541)2.01292144
115Mucopolysacchariduria (HP:0008155)2.01292144
116Joint stiffness (HP:0001387)2.00326206
117Abnormality of cochlea (HP:0000375)2.00202436
118Short 1st metacarpal (HP:0010034)1.99979590
119Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.99979590
120Hypoplasia of the radius (HP:0002984)1.99662041
121Cortical dysplasia (HP:0002539)1.99398765
122Diaphragmatic weakness (HP:0009113)1.99393725
123Medulloblastoma (HP:0002885)1.98911082
124Eosinophilia (HP:0001880)1.98808540
125Split hand (HP:0001171)1.95989751
126Heterotopia (HP:0002282)1.94768895
127Abnormality of the fingertips (HP:0001211)1.93573365
128Macroorchidism (HP:0000053)1.92347853
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.91919278
130Panhypogammaglobulinemia (HP:0003139)1.91209826
131Increased number of teeth (HP:0011069)1.90894467
132Oligodontia (HP:0000677)1.89117514
133Hyperacusis (HP:0010780)1.87961809
134Abnormality of the ileum (HP:0001549)1.87098976
135Agammaglobulinemia (HP:0004432)1.86008157
136Morphological abnormality of the inner ear (HP:0011390)1.85916214
137Prominent nose (HP:0000448)1.85705517
138Severe combined immunodeficiency (HP:0004430)1.85158449
139Hypercortisolism (HP:0001578)1.84872986
140Gastrointestinal atresia (HP:0002589)1.84824588
141Dysautonomia (HP:0002459)1.84435914
142Asplenia (HP:0001746)1.84402608
143Abnormality of endocrine pancreas physiology (HP:0012093)1.84219460
144Abnormality of the pancreatic islet cells (HP:0006476)1.84219460
145Proximal placement of thumb (HP:0009623)1.83869207
146Abnormal number of erythroid precursors (HP:0012131)1.83545828
147Neoplasm of striated muscle (HP:0009728)1.82787802
148Abnormality of polysaccharide metabolism (HP:0011012)1.82761618
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82761618
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82761618
151Protruding tongue (HP:0010808)1.82079101
152Choanal stenosis (HP:0000452)1.81932503
153Alacrima (HP:0000522)1.81590405
154Short thumb (HP:0009778)1.80060744
155Bifid uvula (HP:0000193)1.78652230
156Broad thumb (HP:0011304)1.78570315
157Abnormality of chromosome segregation (HP:0002916)1.78114942
158Cafe-au-lait spot (HP:0000957)1.77167107
159Hypoplastic iliac wings (HP:0002866)1.76719193
160Abnormality of T cell physiology (HP:0011840)1.73270931
161Supernumerary ribs (HP:0005815)1.72224591
162Synostosis of carpal bones (HP:0005048)1.71767439
163Myelodysplasia (HP:0002863)1.71237671
164Impaired smooth pursuit (HP:0007772)1.70447447
165Clubbing of toes (HP:0100760)1.70189681
166Abnormality of cells of the lymphoid lineage (HP:0012140)1.69886585
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.69782466
168Porencephaly (HP:0002132)1.68985624
169Hypoplastic pelvis (HP:0008839)1.68440328
170Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68429224
171Pointed chin (HP:0000307)1.68014231
172Abnormality of the 1st metacarpal (HP:0010009)1.67473123
173Tented upper lip vermilion (HP:0010804)1.67235817
174Pendular nystagmus (HP:0012043)1.67209352
175Pseudobulbar signs (HP:0002200)1.67056266
176Meckel diverticulum (HP:0002245)1.65806953
177Abnormality of the phalanges of the 5th finger (HP:0004213)1.65699874
178Urethral obstruction (HP:0000796)1.65307980
179Deviation of the thumb (HP:0009603)1.63304169
180Skull defect (HP:0001362)1.63133385
181Spina bifida occulta (HP:0003298)1.62952919
182Slow saccadic eye movements (HP:0000514)1.62947867
183Aplasia/Hypoplasia of the spleen (HP:0010451)1.61963301
184Pallor (HP:0000980)1.61446762
185Reticulocytopenia (HP:0001896)1.61151319
186Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60916221
187Sandal gap (HP:0001852)1.60779809
188Combined immunodeficiency (HP:0005387)1.59170690
189Supernumerary bones of the axial skeleton (HP:0009144)1.59117624

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.45761286
2MAPK153.90853767
3MAP3K63.70927404
4DDR23.51399728
5MAP3K113.15417136
6MAP3K102.78132444
7TYRO32.61767133
8MATK2.41189120
9SMG12.40030769
10UHMK12.07892636
11CDK72.05601776
12RIPK42.01458553
13DAPK12.00718940
14CDC72.00399421
15PINK11.96157202
16PRKD21.93808133
17DYRK1B1.86038729
18CDK121.86000309
19FGR1.84923811
20CDK191.83602247
21TRIB31.81466241
22MKNK21.80026714
23NEK21.78895550
24MKNK11.77899440
25PRPF4B1.77264657
26BMX1.75808370
27PDGFRA1.73372304
28PIM21.71750825
29CSK1.68904616
30AKT31.64822971
31EEF2K1.64420163
32CAMK1D1.63220400
33CDK61.62949377
34PIK3CA1.59732331
35YES11.52651562
36DYRK31.49246826
37CAMK1G1.38291927
38PIM11.37645593
39TLK11.37003967
40MAP4K11.32057217
41MAP3K141.27311124
42MAPK111.26820639
43CHEK21.22866920
44WEE11.20180851
45RPS6KB21.16553224
46PLK11.09086422
47RPS6KC11.09075276
48RPS6KL11.09075276
49SRPK11.06253898
50CLK11.05674234
51ATR1.04155286
52PKN21.00038816
53SIK20.99105044
54RET0.99030900
55LATS20.98977526
56MTOR0.97823291
57RPS6KA60.96903885
58KIT0.96799194
59CDK40.96728002
60BTK0.96710967
61TAOK10.92726985
62MAP3K70.91534550
63TRPM70.91043325
64HIPK20.90887270
65KSR20.90212465
66NEK10.87284430
67MAP3K130.86318081
68FGFR40.83389138
69TAOK30.81797271
70BUB10.80156415
71SGK30.78198765
72CDC42BPA0.77007846
73STK100.75951040
74TAOK20.74812988
75CDK20.73593045
76RPS6KA10.73465152
77CDK90.72941891
78ITK0.70373962
79CHEK10.69928756
80FLT30.68087224
81PAK40.66689081
82RAF10.65960128
83GSK3A0.65834250
84GSK3B0.64855921
85FGFR30.64742793
86AURKB0.63386218
87IKBKE0.63158211
88ERN10.62856324
89MAPK100.61339586
90TTK0.60509198
91TESK20.59970942
92AKT10.58363901
93IKBKB0.58076838
94JAK30.57828858
95SYK0.57182054
96PLK40.57064663
97SGK20.56532999
98BLK0.55605174
99MELK0.55546883
100MARK30.55491594
101JAK20.55454199
102PASK0.55406735
103MOS0.55256308
104TEC0.54979789
105MAP3K80.54832803
106PRKAA10.53858546
107MAPK80.52460431
108CHUK0.52283405
109RIPK10.52063258
110GRK60.51916049
111SIK10.51781931
112NLK0.51762839
113WNK10.51351424
114CSNK1A1L0.51112624
115ALK0.51098393
116MAPKAPK30.49738055
117HCK0.48792997
118PHKG10.48640153
119PHKG20.48640153
120SGK10.48570172
121MAP2K30.48299467
122ATM0.47869532
123MAP3K90.47706772
124PRKCH0.47661922
125CDK80.47578167
126LCK0.46775266
127CDK30.46662478
128PRKDC0.46650082
129EPHA30.46328004
130MAPK90.46136789
131SGK2230.45177599
132SGK4940.45177599
133AURKA0.44801242
134PAK20.43483323
135STK30.42872581
136BRSK10.40760184
137CDK10.40658886
138BRD40.40352355
139AKT20.39765319
140CSNK2A10.39195759
141MAPK140.39047154
142MAPK10.38850288
143LYN0.38429999
144PDGFRB0.35550528
145CSNK2A20.34842833
146MAPK40.34303079
147EGFR0.33798660
148MAPK30.33692324
149STK40.32825337
150MARK20.32170924
151LRRK20.30315783
152SCYL20.30226986
153TGFBR10.30195516
154KDR0.29948513
155ACVR1B0.27511203
156RPS6KB10.26929923
157LATS10.26300564
158ERBB30.25967313

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.05552765
2DNA replication_Homo sapiens_hsa030305.05446987
3Base excision repair_Homo sapiens_hsa034104.63452423
4Fatty acid biosynthesis_Homo sapiens_hsa000613.15973458
5* Spliceosome_Homo sapiens_hsa030402.73674523
6Nucleotide excision repair_Homo sapiens_hsa034202.39698654
7Homologous recombination_Homo sapiens_hsa034402.25185664
8RNA transport_Homo sapiens_hsa030132.24314056
9mRNA surveillance pathway_Homo sapiens_hsa030152.24179614
10Cell cycle_Homo sapiens_hsa041102.15864543
11Notch signaling pathway_Homo sapiens_hsa043302.11267396
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04431118
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02416919
14mTOR signaling pathway_Homo sapiens_hsa041501.81338225
15Fanconi anemia pathway_Homo sapiens_hsa034601.78084116
16Type II diabetes mellitus_Homo sapiens_hsa049301.73842265
17Sulfur relay system_Homo sapiens_hsa041221.60935710
18p53 signaling pathway_Homo sapiens_hsa041151.60272931
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57258506
20T cell receptor signaling pathway_Homo sapiens_hsa046601.55866809
21Primary immunodeficiency_Homo sapiens_hsa053401.54024915
22Lysine degradation_Homo sapiens_hsa003101.51577022
23Ribosome_Homo sapiens_hsa030101.50608518
24Biosynthesis of amino acids_Homo sapiens_hsa012301.50072675
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.41743151
26Hippo signaling pathway_Homo sapiens_hsa043901.41034957
27Prolactin signaling pathway_Homo sapiens_hsa049171.37675993
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.34677985
29Hedgehog signaling pathway_Homo sapiens_hsa043401.33229976
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.31898950
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30044613
32Graft-versus-host disease_Homo sapiens_hsa053321.29965784
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.29154297
34Renal cell carcinoma_Homo sapiens_hsa052111.28806850
35FoxO signaling pathway_Homo sapiens_hsa040681.28192228
36Glioma_Homo sapiens_hsa052141.25809300
37Allograft rejection_Homo sapiens_hsa053301.25411688
38Chronic myeloid leukemia_Homo sapiens_hsa052201.24580364
39Circadian rhythm_Homo sapiens_hsa047101.23762852
40One carbon pool by folate_Homo sapiens_hsa006701.22633692
41Bladder cancer_Homo sapiens_hsa052191.21248707
42Colorectal cancer_Homo sapiens_hsa052101.20378150
43Adherens junction_Homo sapiens_hsa045201.20004304
44African trypanosomiasis_Homo sapiens_hsa051431.17487267
45Basal cell carcinoma_Homo sapiens_hsa052171.15344771
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.14919602
47Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13472107
48Autoimmune thyroid disease_Homo sapiens_hsa053201.12858514
49Influenza A_Homo sapiens_hsa051641.08324062
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06988825
51Acute myeloid leukemia_Homo sapiens_hsa052211.05365906
52MicroRNAs in cancer_Homo sapiens_hsa052061.02435242
53Oocyte meiosis_Homo sapiens_hsa041141.00670932
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99857598
55Melanoma_Homo sapiens_hsa052180.98951061
56Arginine and proline metabolism_Homo sapiens_hsa003300.97921627
57VEGF signaling pathway_Homo sapiens_hsa043700.97401890
58TGF-beta signaling pathway_Homo sapiens_hsa043500.96273305
59RNA degradation_Homo sapiens_hsa030180.96047712
60Hepatitis C_Homo sapiens_hsa051600.93558939
61Shigellosis_Homo sapiens_hsa051310.93541469
62Wnt signaling pathway_Homo sapiens_hsa043100.88544888
63Small cell lung cancer_Homo sapiens_hsa052220.88155077
64Thyroid cancer_Homo sapiens_hsa052160.87891759
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87316995
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86386228
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86111554
68Folate biosynthesis_Homo sapiens_hsa007900.85832088
69Insulin resistance_Homo sapiens_hsa049310.84955296
70Asthma_Homo sapiens_hsa053100.84444422
71Viral carcinogenesis_Homo sapiens_hsa052030.82901602
72TNF signaling pathway_Homo sapiens_hsa046680.78923112
73HTLV-I infection_Homo sapiens_hsa051660.78517452
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78050414
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77664755
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75602081
77Viral myocarditis_Homo sapiens_hsa054160.75183854
78MAPK signaling pathway_Homo sapiens_hsa040100.74861741
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.73801143
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72713678
81Leishmaniasis_Homo sapiens_hsa051400.72077305
82Non-homologous end-joining_Homo sapiens_hsa034500.71898830
83Pyrimidine metabolism_Homo sapiens_hsa002400.71032542
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70784611
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70343036
86Type I diabetes mellitus_Homo sapiens_hsa049400.68452834
87Osteoclast differentiation_Homo sapiens_hsa043800.68027227
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.66904486
89B cell receptor signaling pathway_Homo sapiens_hsa046620.64894583
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64894264
91AMPK signaling pathway_Homo sapiens_hsa041520.64030355
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63455846
93* Herpes simplex infection_Homo sapiens_hsa051680.61102788
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.58584973
95Epstein-Barr virus infection_Homo sapiens_hsa051690.58542685
96Fructose and mannose metabolism_Homo sapiens_hsa000510.58329124
97Endometrial cancer_Homo sapiens_hsa052130.57765696
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57655579
99Hepatitis B_Homo sapiens_hsa051610.57219171
100Pancreatic cancer_Homo sapiens_hsa052120.56164682
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56088165
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55911401
103Non-small cell lung cancer_Homo sapiens_hsa052230.54358869
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54207094
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52920211
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52020722
107Insulin signaling pathway_Homo sapiens_hsa049100.51595793
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.51322645
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49215363
110Basal transcription factors_Homo sapiens_hsa030220.48460891
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48337339
112Chemokine signaling pathway_Homo sapiens_hsa040620.46784143
113Toxoplasmosis_Homo sapiens_hsa051450.46578013
114Fatty acid metabolism_Homo sapiens_hsa012120.45569909
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44909581
116Galactose metabolism_Homo sapiens_hsa000520.43129005
117Selenocompound metabolism_Homo sapiens_hsa004500.41007250
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40993727
119Pathways in cancer_Homo sapiens_hsa052000.39370504
120Arginine biosynthesis_Homo sapiens_hsa002200.38874153
121Dorso-ventral axis formation_Homo sapiens_hsa043200.38869684
122ErbB signaling pathway_Homo sapiens_hsa040120.37054304
123Choline metabolism in cancer_Homo sapiens_hsa052310.36693200
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35461356
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.35167304
126Proteoglycans in cancer_Homo sapiens_hsa052050.34643463
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.34013410
128Legionellosis_Homo sapiens_hsa051340.34000038
129N-Glycan biosynthesis_Homo sapiens_hsa005100.33430628
130RNA polymerase_Homo sapiens_hsa030200.32541823
131HIF-1 signaling pathway_Homo sapiens_hsa040660.32045444
132Measles_Homo sapiens_hsa051620.30407206
133Pentose phosphate pathway_Homo sapiens_hsa000300.29625366
134Prostate cancer_Homo sapiens_hsa052150.29514873
135Tight junction_Homo sapiens_hsa045300.29346086
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.29245025
137Gap junction_Homo sapiens_hsa045400.28845874
138Apoptosis_Homo sapiens_hsa042100.25832023
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23771996

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