SRSF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.57022428
2negative regulation of cell killing (GO:0031342)5.57022428
3histone H3-K4 trimethylation (GO:0080182)5.15470256
4positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.93254553
5regulation of B cell receptor signaling pathway (GO:0050855)4.89684175
6regulation of gamma-delta T cell differentiation (GO:0045586)4.79239733
7positive regulation of gamma-delta T cell activation (GO:0046645)4.63480398
8regulation of gamma-delta T cell activation (GO:0046643)4.39591228
9activated T cell proliferation (GO:0050798)4.36867073
10tolerance induction (GO:0002507)4.29555184
11response to muramyl dipeptide (GO:0032495)4.27719685
12peptidyl-lysine trimethylation (GO:0018023)4.19346638
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.12720385
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12720385
15histone H3-K4 methylation (GO:0051568)4.11410204
16negative regulation of erythrocyte differentiation (GO:0045647)4.02557661
17T cell migration (GO:0072678)3.96492954
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.93181319
19positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.92254620
20regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.92254620
21mitotic sister chromatid cohesion (GO:0007064)3.91931547
22negative regulation of lymphocyte mediated immunity (GO:0002707)3.87618995
23regulation of histone H3-K27 methylation (GO:0061085)3.86408894
24negative regulation of T cell mediated immunity (GO:0002710)3.82037623
25response to interleukin-15 (GO:0070672)3.81988269
26positive regulation of histone deacetylation (GO:0031065)3.79718932
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.72354449
28positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.71815074
29regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.71815074
30cellular response to interleukin-15 (GO:0071350)3.70982032
31Peyers patch development (GO:0048541)3.68396816
32mucosal-associated lymphoid tissue development (GO:0048537)3.68396816
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.68052872
34antigen processing and presentation of endogenous antigen (GO:0019883)3.67667694
35regulation of germinal center formation (GO:0002634)3.59200017
36positive T cell selection (GO:0043368)3.56317216
37positive regulation of granulocyte differentiation (GO:0030854)3.56239280
38negative regulation of stress fiber assembly (GO:0051497)3.52260570
39peptidyl-lysine methylation (GO:0018022)3.47659243
40negative T cell selection (GO:0043383)3.47200209
41positive regulation of mRNA catabolic process (GO:0061014)3.42296599
42definitive hemopoiesis (GO:0060216)3.41579256
43negative regulation of leukocyte mediated immunity (GO:0002704)3.38702584
44regulation of mRNA catabolic process (GO:0061013)3.37213976
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35495592
46antigen processing and presentation via MHC class Ib (GO:0002475)3.27295046
47negative regulation of RNA splicing (GO:0033119)3.24759080
48positive thymic T cell selection (GO:0045059)3.15834107
49stress granule assembly (GO:0034063)3.15453988
50Golgi transport vesicle coating (GO:0048200)3.15258924
51COPI coating of Golgi vesicle (GO:0048205)3.15258924
52antigen receptor-mediated signaling pathway (GO:0050851)3.14533364
53negative regulation of mRNA processing (GO:0050686)3.13632357
54positive regulation of tolerance induction (GO:0002645)3.11096889
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.10586894
56regulation of translation, ncRNA-mediated (GO:0045974)3.10586894
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.10586894
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.09703992
59actin nucleation (GO:0045010)3.09250873
60negative regulation of immunoglobulin mediated immune response (GO:0002890)3.07893860
61negative regulation of B cell mediated immunity (GO:0002713)3.07893860
62T cell selection (GO:0045058)3.07171454
63embryonic hemopoiesis (GO:0035162)3.06907462
64detection of bacterium (GO:0016045)3.06713289
65histone lysine methylation (GO:0034968)3.06101206
66regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04468472
67regulation of alpha-beta T cell proliferation (GO:0046640)3.03724918
68leukocyte aggregation (GO:0070486)3.02223491
69negative thymic T cell selection (GO:0045060)2.98777666
70mast cell activation (GO:0045576)2.98073931
713-UTR-mediated mRNA stabilization (GO:0070935)2.97755057
72detection of other organism (GO:0098543)2.96323659
73cytoplasmic mRNA processing body assembly (GO:0033962)2.95811104
74negative regulation of adaptive immune response (GO:0002820)2.95055756
75positive regulation of T cell differentiation in thymus (GO:0033089)2.92827736
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.92508912
77nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.91092385
78negative regulation of mRNA metabolic process (GO:1903312)2.91056702
79regulation of tolerance induction (GO:0002643)2.89272719
80T cell receptor signaling pathway (GO:0050852)2.87954003
81alternative mRNA splicing, via spliceosome (GO:0000380)2.87697751
82germinal center formation (GO:0002467)2.86289105
83regulation of isotype switching to IgG isotypes (GO:0048302)2.86151464
84regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.85203306
85B cell homeostasis (GO:0001782)2.84149666
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.82520627
87histone H4-K16 acetylation (GO:0043984)2.82201995
88insulin-like growth factor receptor signaling pathway (GO:0048009)2.81604313
89positive regulation of gene expression, epigenetic (GO:0045815)2.81202525
90histone H3-K36 demethylation (GO:0070544)2.81038297
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80377929
92exocrine pancreas development (GO:0031017)2.78703120
93peptidyl-lysine dimethylation (GO:0018027)2.78544498
94negative regulation of glycoprotein biosynthetic process (GO:0010561)2.78010608
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.76921005
96histone H3-K9 demethylation (GO:0033169)2.76882364
97regulation of T cell mediated cytotoxicity (GO:0001914)2.76636229
98thymic T cell selection (GO:0045061)2.75728364
99regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74477847
100regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.74402593
101growth hormone receptor signaling pathway (GO:0060396)2.73930511
102negative regulation of histone methylation (GO:0031061)2.73669927
103regulation of RNA export from nucleus (GO:0046831)2.72274517
104cellular response to growth hormone stimulus (GO:0071378)2.72233011
105positive regulation of B cell differentiation (GO:0045579)2.71533019
106regulation of regulatory T cell differentiation (GO:0045589)2.70960428
107neutrophil mediated immunity (GO:0002446)2.70729947
108positive regulation of alpha-beta T cell differentiation (GO:0046638)2.70178974
109regulation of B cell differentiation (GO:0045577)2.68543956
110regulation of granulocyte differentiation (GO:0030852)2.68422715
111glucocorticoid receptor signaling pathway (GO:0042921)2.67009732
112alpha-beta T cell differentiation (GO:0046632)2.66392442
113regulation of T cell tolerance induction (GO:0002664)2.65596466
114regulation of interleukin-4 production (GO:0032673)2.65310763
115positive regulation of T cell differentiation (GO:0045582)2.64534589
116regulation of natural killer cell mediated immunity (GO:0002715)2.63031654
117regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63031654
118histone H3 deacetylation (GO:0070932)2.62746885
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.62050492
120regulation of alpha-beta T cell activation (GO:0046634)2.61997675
121positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.61708773
122positive regulation of antigen processing and presentation (GO:0002579)2.61382101
123negative regulation of type 2 immune response (GO:0002829)2.61273772
124regulation of antigen processing and presentation (GO:0002577)2.61133428
125positive regulation of protein deacetylation (GO:0090312)2.60176750
126positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59480901
127regulation of interleukin-2 biosynthetic process (GO:0045076)2.57413150
128histone H3-K9 modification (GO:0061647)2.57180852
129T cell differentiation in thymus (GO:0033077)2.56942939
130regulation of alpha-beta T cell differentiation (GO:0046637)2.56935667
131cellular extravasation (GO:0045123)2.56484207
132negative regulation of innate immune response (GO:0045824)2.56121854
133positive regulation of alpha-beta T cell activation (GO:0046635)2.56088321
134regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.55370536
135retrograde transport, vesicle recycling within Golgi (GO:0000301)2.54508086
136regulation of nucleobase-containing compound transport (GO:0032239)2.53926903
137dosage compensation (GO:0007549)2.53658762
138neutrophil activation (GO:0042119)2.53055769
139immunoglobulin mediated immune response (GO:0016064)2.52950376
140regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.52930607
141V(D)J recombination (GO:0033151)2.52877552
142RNA stabilization (GO:0043489)2.51415857
143mRNA stabilization (GO:0048255)2.51415857
144genitalia morphogenesis (GO:0035112)2.51261059
145histone lysine demethylation (GO:0070076)2.49325751
146interferon-gamma production (GO:0032609)2.48626748
147negative regulation of thymocyte apoptotic process (GO:0070244)2.46529354
148T cell differentiation (GO:0030217)2.43587707
149positive regulation of histone H3-K4 methylation (GO:0051571)2.43319793
150blood vessel maturation (GO:0001955)2.43198918
151B cell receptor signaling pathway (GO:0050853)2.42988431
152regulation of RNA splicing (GO:0043484)2.42532306
153regulation of skeletal muscle cell differentiation (GO:2001014)2.42000081
154regulation of histone H3-K4 methylation (GO:0051569)2.41322941
155regulation of erythrocyte differentiation (GO:0045646)2.40897781
156regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.37068738
157regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.34976781
158venous blood vessel morphogenesis (GO:0048845)2.34961315
159histone demethylation (GO:0016577)2.34802606
160regulation of DNA endoreduplication (GO:0032875)2.34449895
161positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33695777
162histone methylation (GO:0016571)2.32538252
163* mRNA splice site selection (GO:0006376)2.31655104
164positive regulation of RNA splicing (GO:0033120)2.30548811
165negative regulation of bone resorption (GO:0045779)2.30389740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.04390813
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.02326322
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.62686646
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.15709118
5GATA1_22025678_ChIP-Seq_K562_Human4.05443031
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.92062283
7MYC_22102868_ChIP-Seq_BL_Human3.77835754
8SCL_19346495_ChIP-Seq_HPC-7_Human3.63410999
9RUNX_20019798_ChIP-Seq_JUKART_Human3.11914449
10TCF7_22412390_ChIP-Seq_EML_Mouse2.70081214
11E2F7_22180533_ChIP-Seq_HELA_Human2.61372941
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.60962804
13CLOCK_20551151_ChIP-Seq_293T_Human2.58775498
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.43974013
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36581930
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.35050009
17CIITA_25753668_ChIP-Seq_RAJI_Human2.32436139
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.31695379
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27441189
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.22279237
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.18125920
22VDR_21846776_ChIP-Seq_THP-1_Human2.16652089
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.15952908
24MYB_26560356_Chip-Seq_TH2_Human2.10657776
25MYB_26560356_Chip-Seq_TH1_Human2.03170315
26UTX_26944678_Chip-Seq_JUKART_Human1.97426274
27DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.95040233
28MAF_26560356_Chip-Seq_TH1_Human1.93475634
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86418409
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86068479
31KDM2B_26808549_Chip-Seq_DND41_Human1.85930527
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.83208226
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80389366
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77864631
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.75889369
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72947341
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72759128
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.72505315
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.72158402
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.70381813
41GATA3_26560356_Chip-Seq_TH2_Human1.65863477
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60807070
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58645359
44IGF1R_20145208_ChIP-Seq_DFB_Human1.57629025
45VDR_24763502_ChIP-Seq_THP-1_Human1.57078527
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55958195
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54875383
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51420791
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49427640
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47800620
51GATA3_27048872_Chip-Seq_THYMUS_Human1.44055342
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40589870
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.40333383
54SPI1_23127762_ChIP-Seq_K562_Human1.39910774
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.39512948
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.39165355
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38221396
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.38149278
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37761805
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35735464
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35411746
62* FOXM1_23109430_ChIP-Seq_U2OS_Human1.33396797
63NCOR1_26117541_ChIP-Seq_K562_Human1.33348040
64FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33197835
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31949300
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.29034136
67TP53_16413492_ChIP-PET_HCT116_Human1.28469886
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27930604
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27262034
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26272959
71GATA1_19941826_ChIP-Seq_K562_Human1.23142030
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22032935
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.21035102
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19341441
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.19317978
76VDR_24787735_ChIP-Seq_THP-1_Human1.19048945
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17509861
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15598495
79BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14567264
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.12518524
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.12214052
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11657655
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10279816
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09885385
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08829706
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08123946
87SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.07324647
88DROSHA_22980978_ChIP-Seq_HELA_Human1.07186122
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06736313
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06206220
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06084402
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05730017
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.05366505
94GATA2_19941826_ChIP-Seq_K562_Human1.04460902
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03069762
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02869681
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01832990
98IRF1_19129219_ChIP-ChIP_H3396_Human1.00844797
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00803060
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00311246
101IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99335018
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98652899
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98518843
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97535850
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.97487095
106CHD1_26751641_Chip-Seq_LNCaP_Human0.96999293
107IRF8_27001747_Chip-Seq_BMDM_Mouse0.96339472
108PU_27001747_Chip-Seq_BMDM_Mouse0.95983139
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95963126
110VDR_23849224_ChIP-Seq_CD4+_Human0.95456110
111FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93385846
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92356504
113HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92144371
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90845752
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90743907
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90196768
117SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90162649
118FOXA2_19822575_ChIP-Seq_HepG2_Human0.89471543
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88889249
120RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88723935
121SPI1_23547873_ChIP-Seq_NB4_Human0.88266569
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87880527
123ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87708385
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87215423
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.86598861
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85950180
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.85938771
128NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85511354
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85275557
130MAF_26560356_Chip-Seq_TH2_Human0.84739222
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82838072
132BCL6_27268052_Chip-Seq_Bcells_Human0.82211969
133CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82075323
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81658217
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81322836
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80569028
137PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77384642
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.77209284
139SMAD_19615063_ChIP-ChIP_OVARY_Human0.77147034
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76587705
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75839589
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74526572
143WDR5_24793694_ChIP-Seq_LNCAP_Human0.74041833
144KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74027733
145KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74027733
146KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74027733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.55901659
2MP0003724_increased_susceptibility_to3.54723330
3MP0002166_altered_tumor_susceptibility3.37529475
4MP0002396_abnormal_hematopoietic_system3.35145173
5MP0003763_abnormal_thymus_physiology2.92526157
6MP0003300_gastrointestinal_ulcer2.88659620
7MP0004808_abnormal_hematopoietic_stem2.88222510
8MP0005000_abnormal_immune_tolerance2.75637195
9MP0003183_abnormal_peptide_metabolism2.39771983
10MP0003303_peritoneal_inflammation2.34598999
11MP0002006_tumorigenesis2.33930261
12MP0005025_abnormal_response_to2.27667071
13MP0008961_abnormal_basal_metabolism2.27604143
14MP0002009_preneoplasia2.25983417
15MP0002419_abnormal_innate_immunity2.13919665
16MP0008995_early_reproductive_senescence2.12594002
17MP0000569_abnormal_digit_pigmentation2.12058167
18MP0006054_spinal_hemorrhage2.03374826
19MP0010234_abnormal_vibrissa_follicle2.01638794
20MP0001873_stomach_inflammation2.01330680
21MP0004947_skin_inflammation2.00086401
22MP0000703_abnormal_thymus_morphology1.96784967
23MP0004264_abnormal_extraembryonic_tissu1.91394549
24MP0000685_abnormal_immune_system1.84898873
25MP0009785_altered_susceptibility_to1.84364485
26MP0009278_abnormal_bone_marrow1.77079788
27MP0002928_abnormal_bile_duct1.72987543
28MP0003690_abnormal_glial_cell1.69393870
29MP0002398_abnormal_bone_marrow1.69144486
30MP0005671_abnormal_response_to1.68067041
31MP0001545_abnormal_hematopoietic_system1.67051265
32MP0005397_hematopoietic_system_phenotyp1.67051265
33MP0010352_gastrointestinal_tract_polyps1.62930128
34MP0005365_abnormal_bile_salt1.61040075
35MP0001800_abnormal_humoral_immune1.58970570
36MP0003880_abnormal_central_pattern1.54592290
37MP0000465_gastrointestinal_hemorrhage1.52017665
38MP0003787_abnormal_imprinting1.51806917
39MP0003045_fibrosis1.51397736
40MP0003866_abnormal_defecation1.49161573
41MP0002653_abnormal_ependyma_morphology1.47586527
42MP0008007_abnormal_cellular_replicative1.46707469
43MP0005220_abnormal_exocrine_pancreas1.46682311
44MP0002254_reproductive_system_inflammat1.42090071
45MP0001533_abnormal_skeleton_physiology1.42060767
46MP0000003_abnormal_adipose_tissue1.40789004
47MP0002822_catalepsy1.40221201
48MP0008260_abnormal_autophagy1.39626038
49MP0005646_abnormal_pituitary_gland1.39550272
50MP0005076_abnormal_cell_differentiation1.38727764
51MP0002722_abnormal_immune_system1.36774957
52MP0002148_abnormal_hypersensitivity_rea1.35809619
53MP0001986_abnormal_taste_sensitivity1.34304911
54MP0010678_abnormal_skin_adnexa1.33098588
55MP0003656_abnormal_erythrocyte_physiolo1.32744172
56MP0001835_abnormal_antigen_presentation1.32403494
57MP0003828_pulmonary_edema1.32014404
58MP0000716_abnormal_immune_system1.30233838
59MP0000689_abnormal_spleen_morphology1.30065348
60MP0002420_abnormal_adaptive_immunity1.28037127
61MP0001853_heart_inflammation1.27765306
62MP0003943_abnormal_hepatobiliary_system1.26935066
63MP0000383_abnormal_hair_follicle1.23721369
64MP0001819_abnormal_immune_cell1.22925733
65MP0001501_abnormal_sleep_pattern1.19575894
66MP0003566_abnormal_cell_adhesion1.19334611
67MP0010155_abnormal_intestine_physiology1.18603428
68MP0002452_abnormal_antigen_presenting1.16938983
69MP0005464_abnormal_platelet_physiology1.16456368
70MP0003252_abnormal_bile_duct1.15874306
71MP0009333_abnormal_splenocyte_physiolog1.14048036
72MP0010307_abnormal_tumor_latency1.13250103
73MP0002429_abnormal_blood_cell1.12667183
74MP0003122_maternal_imprinting1.11873272
75MP0001849_ear_inflammation1.10303206
76MP0004147_increased_porphyrin_level1.09842436
77MP0002723_abnormal_immune_serum1.09389382
78MP0001243_abnormal_dermal_layer1.08604254
79MP0000537_abnormal_urethra_morphology1.08035925
80MP0002877_abnormal_melanocyte_morpholog1.07663262
81MP0004859_abnormal_synaptic_plasticity1.07283246
82MP0005387_immune_system_phenotype1.05874894
83MP0001790_abnormal_immune_system1.05874894
84MP0002089_abnormal_postnatal_growth/wei1.05176992
85MP0001879_abnormal_lymphatic_vessel1.03253765
86MP0006082_CNS_inflammation0.98698889
87MP0001270_distended_abdomen0.98131308
88MP0002132_abnormal_respiratory_system0.97744775
89MP0002138_abnormal_hepatobiliary_system0.97016023
90MP0003329_amyloid_beta_deposits0.96637031
91MP0000604_amyloidosis0.96223959
92MP0002060_abnormal_skin_morphology0.95919099
93MP0002095_abnormal_skin_pigmentation0.94167106
94MP0006072_abnormal_retinal_apoptosis0.91833955
95MP0009764_decreased_sensitivity_to0.91321842
96MP0008569_lethality_at_weaning0.91083168
97MP0001944_abnormal_pancreas_morphology0.91028027
98MP0005375_adipose_tissue_phenotype0.90952884
99MP0003868_abnormal_feces_composition0.90268239
100MP0003221_abnormal_cardiomyocyte_apopto0.89854092
101MP0001191_abnormal_skin_condition0.89709060
102MP0001984_abnormal_olfaction0.89028397
103MP0009763_increased_sensitivity_to0.88174711
104MP0003172_abnormal_lysosome_physiology0.87936739
105MP0004130_abnormal_muscle_cell0.87745478
106MP0005174_abnormal_tail_pigmentation0.87682261
107MP0004883_abnormal_blood_vessel0.87523521
108MP0002638_abnormal_pupillary_reflex0.87506008
109MP0001502_abnormal_circadian_rhythm0.87053809
110MP0001851_eye_inflammation0.86686998
111MP0004885_abnormal_endolymph0.85471057
112MP0005075_abnormal_melanosome_morpholog0.84530622
113MP0009780_abnormal_chondrocyte_physiolo0.84385080
114MP0005023_abnormal_wound_healing0.83932630
115MP0002925_abnormal_cardiovascular_devel0.83784975
116MP0008469_abnormal_protein_level0.82285758
117MP0002933_joint_inflammation0.81815392
118MP0005499_abnormal_olfactory_system0.81366500
119MP0005394_taste/olfaction_phenotype0.81366500
120MP0009765_abnormal_xenobiotic_induced0.78995902
121MP0001915_intracranial_hemorrhage0.78257838
122MP0000767_abnormal_smooth_muscle0.77078074
123MP0005275_abnormal_skin_tensile0.76466581
124MP0005535_abnormal_body_temperature0.74420336
125MP0003191_abnormal_cellular_cholesterol0.74295122
126MP0002909_abnormal_adrenal_gland0.74229732
127MP0002092_abnormal_eye_morphology0.74228341
128MP0000428_abnormal_craniofacial_morphol0.73369694
129MP0003279_aneurysm0.73032106
130MP0004197_abnormal_fetal_growth/weight/0.72957719
131MP0002086_abnormal_extraembryonic_tissu0.70586539
132MP0002405_respiratory_system_inflammati0.69284549
133MP0002998_abnormal_bone_remodeling0.68656671
134MP0000477_abnormal_intestine_morphology0.67427822
135MP0004782_abnormal_surfactant_physiolog0.67426321
136MP0000609_abnormal_liver_physiology0.67246159
137MP0009703_decreased_birth_body0.67166460
138MP0001845_abnormal_inflammatory_respons0.65670949
139MP0002019_abnormal_tumor_incidence0.65594889
140MP0000249_abnormal_blood_vessel0.65131967
141MP0010094_abnormal_chromosome_stability0.64925611
142MP0002133_abnormal_respiratory_system0.64815006
143MP0005388_respiratory_system_phenotype0.64815006
144MP0000350_abnormal_cell_proliferation0.64665013
145MP0000858_altered_metastatic_potential0.64656158
146MP0005391_vision/eye_phenotype0.64589156
147MP0005310_abnormal_salivary_gland0.63950797
148MP0001784_abnormal_fluid_regulation0.63895867
149MP0003121_genomic_imprinting0.63020307
150MP0005645_abnormal_hypothalamus_physiol0.60206223
151MP0005423_abnormal_somatic_nervous0.59468045
152MP0002063_abnormal_learning/memory/cond0.56716670
153MP0004484_altered_response_of0.55172061
154MP0009115_abnormal_fat_cell0.51742882
155MP0001188_hyperpigmentation0.51104679

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.56185197
2Eczematoid dermatitis (HP:0000976)4.51683212
3Elevated erythrocyte sedimentation rate (HP:0003565)4.24044207
4Papilledema (HP:0001085)4.15410258
5Myositis (HP:0100614)4.02652244
6Stomach cancer (HP:0012126)3.55502706
7Volvulus (HP:0002580)3.52881546
8Meningitis (HP:0001287)3.50349717
9Mediastinal lymphadenopathy (HP:0100721)3.50048796
10Retrobulbar optic neuritis (HP:0100654)3.45550082
11Optic neuritis (HP:0100653)3.45550082
12Stomatitis (HP:0010280)3.41419745
13Recurrent cutaneous fungal infections (HP:0011370)3.41320545
14Chronic mucocutaneous candidiasis (HP:0002728)3.41320545
15Increased IgE level (HP:0003212)3.40314868
16Macroorchidism (HP:0000053)3.37489875
17IgG deficiency (HP:0004315)3.33898582
18Combined immunodeficiency (HP:0005387)3.32984590
19Panhypogammaglobulinemia (HP:0003139)3.27073778
20Hypoplasia of the thymus (HP:0000778)3.26467488
21Recurrent sinusitis (HP:0011108)3.25824715
22Encephalitis (HP:0002383)3.24534477
23Aortic aneurysm (HP:0004942)3.20017401
24Orchitis (HP:0100796)3.18609982
25Recurrent bacterial skin infections (HP:0005406)3.15153138
26Abnormality of B cell number (HP:0010975)3.08257825
27B lymphocytopenia (HP:0010976)3.08257825
28Leukocytosis (HP:0001974)2.97093966
29Narrow palate (HP:0000189)2.92532767
30Recurrent abscess formation (HP:0002722)2.90350883
31Vasculitis (HP:0002633)2.85545721
32T lymphocytopenia (HP:0005403)2.81756835
33Alveolar cell carcinoma (HP:0006519)2.74357221
34Recurrent skin infections (HP:0001581)2.74106271
35Gastrointestinal infarctions (HP:0005244)2.68363101
36Long eyelashes (HP:0000527)2.67764589
37Recurrent viral infections (HP:0004429)2.64272255
38Neoplasm of the tracheobronchial system (HP:0100552)2.63754711
39Cerebral aneurysm (HP:0004944)2.62855519
40Keratoconjunctivitis sicca (HP:0001097)2.62098905
41Abnormality of the prostate (HP:0008775)2.61631571
42Lip pit (HP:0100267)2.61327129
43Amyotrophic lateral sclerosis (HP:0007354)2.60137881
44Autoimmune hemolytic anemia (HP:0001890)2.58096077
45Broad metatarsal (HP:0001783)2.57457337
46Keratoconjunctivitis (HP:0001096)2.57022915
47Depressed nasal tip (HP:0000437)2.55291750
48Abnormality of T cell number (HP:0011839)2.51349304
49Acute lymphatic leukemia (HP:0006721)2.50300366
50Thyroiditis (HP:0100646)2.49793708
51Chest pain (HP:0100749)2.49156752
52Recurrent gram-negative bacterial infections (HP:0005420)2.48715177
53Pulmonary infiltrates (HP:0002113)2.48428282
54Cellulitis (HP:0100658)2.48316789
55Growth hormone excess (HP:0000845)2.45090205
56Bronchitis (HP:0012387)2.43517991
57Abnormality of the nasal septum (HP:0000419)2.43072832
58Chronic otitis media (HP:0000389)2.41307272
59Lymphopenia (HP:0001888)2.41283565
60Abnormality of the columella (HP:0009929)2.41234549
61Hypergammaglobulinemia (HP:0010702)2.39139701
62Interstitial pulmonary disease (HP:0006530)2.36434888
63Abnormality of T cell physiology (HP:0011840)2.36213771
64Increased IgM level (HP:0003496)2.33627232
65Obstructive lung disease (HP:0006536)2.32270686
66Chronic obstructive pulmonary disease (HP:0006510)2.32270686
67Pustule (HP:0200039)2.27563643
68Hypoproteinemia (HP:0003075)2.27036886
69Blepharitis (HP:0000498)2.26844258
70Autoimmune thrombocytopenia (HP:0001973)2.26651261
71Sepsis (HP:0100806)2.25335355
72Ureteral stenosis (HP:0000071)2.20949794
73Papilloma (HP:0012740)2.18019461
74Verrucae (HP:0200043)2.18019461
75Seborrheic dermatitis (HP:0001051)2.18016135
76Peripheral hypomyelination (HP:0007182)2.17134921
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.16959280
78Striae distensae (HP:0001065)2.16744606
79Joint swelling (HP:0001386)2.16512239
80Basal cell carcinoma (HP:0002671)2.16050671
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15890319
82Hemoptysis (HP:0002105)2.15817178
83Agammaglobulinemia (HP:0004432)2.14771118
84Truncal obesity (HP:0001956)2.13901748
85Abnormality of the pleura (HP:0002103)2.12945012
86Ureteral obstruction (HP:0006000)2.12555682
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.12234341
88Short 4th metacarpal (HP:0010044)2.12234341
89Hematochezia (HP:0002573)2.12011835
90Acute myeloid leukemia (HP:0004808)2.11771035
91Eosinophilia (HP:0001880)2.10581774
92Broad palm (HP:0001169)2.10482182
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09811694
94Neoplasm of the oral cavity (HP:0100649)2.09742575
95Severe combined immunodeficiency (HP:0004430)2.07736111
96Trigonocephaly (HP:0000243)2.06591601
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06464170
98Prominent nose (HP:0000448)2.05910999
99Viral hepatitis (HP:0006562)2.05609419
100Urethral obstruction (HP:0000796)2.04312844
101Vertebral arch anomaly (HP:0008438)2.04129869
102Aortic dissection (HP:0002647)2.03907405
103IgM deficiency (HP:0002850)2.03119099
104Prolonged bleeding time (HP:0003010)2.02825214
105Spondylolisthesis (HP:0003302)2.01570598
106Supernumerary ribs (HP:0005815)2.01566415
107Obsessive-compulsive behavior (HP:0000722)2.01025110
108Recurrent otitis media (HP:0000403)2.00132898
109Dislocated radial head (HP:0003083)1.99818728
110Pulmonary embolism (HP:0002204)1.99532634
111Abnormality of male internal genitalia (HP:0000022)1.99496892
112Gangrene (HP:0100758)1.99194614
113Abnormal respiratory epithelium morphology (HP:0012253)1.98285922
114Abnormal respiratory motile cilium morphology (HP:0005938)1.98285922
115Amaurosis fugax (HP:0100576)1.98220558
116Enlarged penis (HP:0000040)1.96331129
117Sparse lateral eyebrow (HP:0005338)1.95959269
118Abnormality of binocular vision (HP:0011514)1.95477993
119Diplopia (HP:0000651)1.95477993
120Pseudobulbar signs (HP:0002200)1.95294518
121Chronic diarrhea (HP:0002028)1.94596308
122Granulocytopenia (HP:0001913)1.94397548
123Ependymoma (HP:0002888)1.93846418
124Hemiplegia (HP:0002301)1.92839139
125Gastrointestinal stroma tumor (HP:0100723)1.92610014
126Neoplasm of the heart (HP:0100544)1.91859683
127Broad face (HP:0000283)1.91109924
128Supernumerary bones of the axial skeleton (HP:0009144)1.90974605
129Recurrent fungal infections (HP:0002841)1.89841384
130Fatigue (HP:0012378)1.89743348
131Aneurysm (HP:0002617)1.88101323
132Slow saccadic eye movements (HP:0000514)1.87729822
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.87135143
134Abnormality of the radial head (HP:0003995)1.86350443
135Colitis (HP:0002583)1.86015638
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86004371
137Ectropion (HP:0000656)1.85422225
138Anal stenosis (HP:0002025)1.85030200
139Genetic anticipation (HP:0003743)1.84920393
140Bronchiectasis (HP:0002110)1.84893670
141Skin rash (HP:0000988)1.84541450
142Pulmonary fibrosis (HP:0002206)1.82664609
143Milia (HP:0001056)1.81512905
144Shallow orbits (HP:0000586)1.80305993
145Smooth philtrum (HP:0000319)1.79227924
146Periodontitis (HP:0000704)1.77749527
147Hypoglycemic seizures (HP:0002173)1.77522728
148Aortic regurgitation (HP:0001659)1.77294254
149Hyperacusis (HP:0010780)1.76080721
150Inflammation of the large intestine (HP:0002037)1.74879663
151Low anterior hairline (HP:0000294)1.74620433
152Gastrointestinal inflammation (HP:0004386)1.74547819
153Heterotopia (HP:0002282)1.73236811
154Deep philtrum (HP:0002002)1.72961421
155Abnormality of T cells (HP:0002843)1.71488183
156Increased nuchal translucency (HP:0010880)1.70401079
157Abnormality of eosinophils (HP:0001879)1.66871614
158Recurrent bronchitis (HP:0002837)1.65954858
159Absent frontal sinuses (HP:0002688)1.65571061
160Elfin facies (HP:0004428)1.64745432
161Bicuspid aortic valve (HP:0001647)1.63365706
162Skin tags (HP:0010609)1.62879044
163Arterial thrombosis (HP:0004420)1.61757031
164Poikiloderma (HP:0001029)1.60972734
165Hypoplastic labia majora (HP:0000059)1.60577948
166Proximal placement of thumb (HP:0009623)1.60429101
167Emphysema (HP:0002097)1.58540218
168Abnormality of the epiphyses of the hand (HP:0005924)1.57931619
169Spinal canal stenosis (HP:0003416)1.57908400
170Dysmetric saccades (HP:0000641)1.57288301
171Abnormality of the pancreatic islet cells (HP:0006476)1.57111957
172Abnormality of endocrine pancreas physiology (HP:0012093)1.57111957
173Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56773145
174Gingival bleeding (HP:0000225)1.56632199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD42.99078341
2SIK12.65383898
3EEF2K2.54701175
4RIPK42.47456475
5FES2.44486746
6CDK122.43972486
7MAP4K12.41779648
8TGFBR22.34347236
9GRK62.18214141
10MAPK152.17213823
11TXK2.16769176
12FLT32.09462737
13INSRR2.02539201
14PRPF4B2.01170254
15CAMK1D1.99640206
16CAMK1G1.92208040
17RIPK11.84367517
18ITK1.84294461
19TAOK31.80032538
20BLK1.73649759
21MAP3K131.72438240
22SIK21.68125528
23FGFR41.57195248
24TBK11.51138712
25MAP3K71.49026274
26RPS6KB21.46510954
27UHMK11.45161368
28FGFR21.44659783
29TESK21.43315448
30LATS11.43255699
31KIT1.42920788
32ERN11.41048833
33FGFR31.39990100
34BTK1.39285832
35CSK1.34980319
36TNIK1.33724839
37JAK31.33221770
38CAMKK11.26797941
39PTK61.26227327
40SIK31.25912503
41MAP2K21.24855811
42CSF1R1.24657665
43TRIB31.24052526
44MAP3K101.21832660
45TEC1.20907724
46IRAK41.19645854
47JAK11.17311370
48YES11.16704229
49CDK61.15317957
50PKN21.14842125
51LYN1.14696449
52MAPK71.10639463
53PASK1.10197996
54ZAP701.10143477
55PDGFRB1.09536324
56TYK21.08165347
57STK101.07342480
58TGFBR11.03896840
59SGK31.00672491
60CHUK0.97311328
61HIPK20.96287320
62MTOR0.95610555
63BCR0.92994669
64TSSK60.92783305
65MARK20.92567008
66EPHB10.88173510
67DYRK1B0.87618597
68LRRK20.87404359
69MAPKAPK30.87095183
70BMPR20.85669352
71IRAK10.85655240
72PAK20.84609374
73ATR0.84011275
74SCYL20.83946335
75SGK20.83003734
76MATK0.82607515
77CDK190.81029231
78PIK3CG0.79211940
79EPHA30.77583046
80MKNK10.76998519
81TTN0.76908002
82KDR0.76198713
83BCKDK0.75621555
84SRPK10.75604083
85PIM10.75073966
86CDK30.72808586
87MAP3K40.70266006
88HCK0.70095589
89ERBB30.68688359
90FGFR10.68580584
91FYN0.68463793
92MKNK20.68141283
93CDK90.67856976
94CAMKK20.67277473
95PRKCQ0.66515330
96PRKAA20.66155991
97TNK20.65536679
98LCK0.65490655
99MAP2K30.65043901
100CDK40.64918840
101PDGFRA0.63936300
102NTRK20.63746511
103CAMK40.63739319
104FGR0.62018149
105CDC42BPA0.60608161
106CAMK10.58933870
107NEK20.58287867
108PRKCH0.58026010
109DMPK0.57056490
110JAK20.55278663
111MARK30.55277420
112IKBKE0.55103041
113TYRO30.54783240
114MAP3K140.54643490
115DYRK30.54280659
116NLK0.54013516
117IGF1R0.52659521
118SGK2230.51888893
119SGK4940.51888893
120AKT30.51669638
121RPS6KA40.51555236
122MAPK110.49667685
123MAPK130.49645997
124RPS6KL10.49566527
125RPS6KC10.49566527
126MAPK30.48946536
127CSNK1A1L0.48757267
128SYK0.47919247
129PTK20.47015773
130NUAK10.46404348
131PAK40.46325398
132DYRK1A0.46267610
133NEK60.45776709
134MAPK120.45336401
135MAPK10.44508091
136MAP3K60.44225262
137PDK10.44224629
138RET0.43894701
139IKBKB0.43768387
140RPS6KA60.42926532
141MAP2K70.37746333
142EPHA40.36118719

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.96299785
2Graft-versus-host disease_Homo sapiens_hsa053322.78226558
3Allograft rejection_Homo sapiens_hsa053302.70208180
4Autoimmune thyroid disease_Homo sapiens_hsa053202.63907396
5Lysine degradation_Homo sapiens_hsa003102.26082981
6Type I diabetes mellitus_Homo sapiens_hsa049402.14690972
7Asthma_Homo sapiens_hsa053102.13095514
8Staphylococcus aureus infection_Homo sapiens_hsa051501.93070593
9Circadian rhythm_Homo sapiens_hsa047101.74580127
10T cell receptor signaling pathway_Homo sapiens_hsa046601.73254688
11B cell receptor signaling pathway_Homo sapiens_hsa046621.72684062
12Transcriptional misregulation in cancer_Homo sapiens_hsa052021.69554870
13Antigen processing and presentation_Homo sapiens_hsa046121.60755520
14Notch signaling pathway_Homo sapiens_hsa043301.52422529
15Viral myocarditis_Homo sapiens_hsa054161.44632344
16Hematopoietic cell lineage_Homo sapiens_hsa046401.44343251
17Chronic myeloid leukemia_Homo sapiens_hsa052201.44187288
18Caffeine metabolism_Homo sapiens_hsa002321.42706490
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.41075233
20Small cell lung cancer_Homo sapiens_hsa052221.37860710
21Acute myeloid leukemia_Homo sapiens_hsa052211.36576945
22Osteoclast differentiation_Homo sapiens_hsa043801.30753038
23Type II diabetes mellitus_Homo sapiens_hsa049301.28189302
24Tuberculosis_Homo sapiens_hsa051521.26692833
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26516293
26Colorectal cancer_Homo sapiens_hsa052101.20722288
27Insulin resistance_Homo sapiens_hsa049311.20652060
28Measles_Homo sapiens_hsa051621.20309404
29Platelet activation_Homo sapiens_hsa046111.15657585
30Non-homologous end-joining_Homo sapiens_hsa034501.14178167
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11561871
32ABC transporters_Homo sapiens_hsa020101.10542063
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10292389
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.08820887
35Other glycan degradation_Homo sapiens_hsa005111.08727445
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08713347
37Regulation of autophagy_Homo sapiens_hsa041401.07339208
38mTOR signaling pathway_Homo sapiens_hsa041501.06329226
39Pancreatic cancer_Homo sapiens_hsa052121.05363684
40* Herpes simplex infection_Homo sapiens_hsa051681.03510845
41HTLV-I infection_Homo sapiens_hsa051661.02088393
42Pertussis_Homo sapiens_hsa051331.01081092
43Hepatitis B_Homo sapiens_hsa051611.01043735
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.00736866
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98839570
46Toxoplasmosis_Homo sapiens_hsa051450.98403113
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.98351987
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.97049700
49Adherens junction_Homo sapiens_hsa045200.95215066
50Nitrogen metabolism_Homo sapiens_hsa009100.95110762
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93885044
52FoxO signaling pathway_Homo sapiens_hsa040680.93029941
53Proteoglycans in cancer_Homo sapiens_hsa052050.92198635
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91919333
55Non-small cell lung cancer_Homo sapiens_hsa052230.90891660
56Endometrial cancer_Homo sapiens_hsa052130.89685575
57MicroRNAs in cancer_Homo sapiens_hsa052060.89438267
58Prostate cancer_Homo sapiens_hsa052150.86032844
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84250041
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83877003
61mRNA surveillance pathway_Homo sapiens_hsa030150.83634431
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83054914
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82624351
64Influenza A_Homo sapiens_hsa051640.80265058
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79020946
66Epstein-Barr virus infection_Homo sapiens_hsa051690.78311629
67N-Glycan biosynthesis_Homo sapiens_hsa005100.78179091
68Inositol phosphate metabolism_Homo sapiens_hsa005620.77530855
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76997548
70Pancreatic secretion_Homo sapiens_hsa049720.76960182
71Rheumatoid arthritis_Homo sapiens_hsa053230.76015434
72Prolactin signaling pathway_Homo sapiens_hsa049170.75468883
73* Spliceosome_Homo sapiens_hsa030400.75415277
74Amphetamine addiction_Homo sapiens_hsa050310.74771535
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74481333
76Focal adhesion_Homo sapiens_hsa045100.73687210
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72665750
78Pathways in cancer_Homo sapiens_hsa052000.72519411
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71662597
80Leishmaniasis_Homo sapiens_hsa051400.71654617
81Insulin secretion_Homo sapiens_hsa049110.71359361
82Hepatitis C_Homo sapiens_hsa051600.71050922
83Apoptosis_Homo sapiens_hsa042100.70782939
84RNA degradation_Homo sapiens_hsa030180.70485970
85Shigellosis_Homo sapiens_hsa051310.70392058
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70233646
87Thyroid hormone synthesis_Homo sapiens_hsa049180.68993659
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68126921
89Viral carcinogenesis_Homo sapiens_hsa052030.67780928
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67773284
91VEGF signaling pathway_Homo sapiens_hsa043700.67716899
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67598723
93Thyroid cancer_Homo sapiens_hsa052160.67065556
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66578904
95Chemokine signaling pathway_Homo sapiens_hsa040620.66482670
96Legionellosis_Homo sapiens_hsa051340.65835863
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65570833
98cAMP signaling pathway_Homo sapiens_hsa040240.64411090
99ECM-receptor interaction_Homo sapiens_hsa045120.64364649
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.62684915
101TNF signaling pathway_Homo sapiens_hsa046680.62041970
102Phagosome_Homo sapiens_hsa041450.61201336
103Long-term potentiation_Homo sapiens_hsa047200.61124432
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.60204277
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59710018
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59682839
107Insulin signaling pathway_Homo sapiens_hsa049100.59013056
108Malaria_Homo sapiens_hsa051440.58328928
109p53 signaling pathway_Homo sapiens_hsa041150.57864580
110Protein digestion and absorption_Homo sapiens_hsa049740.57638452
111Estrogen signaling pathway_Homo sapiens_hsa049150.56749059
112Glucagon signaling pathway_Homo sapiens_hsa049220.56663907
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56421069
114Linoleic acid metabolism_Homo sapiens_hsa005910.56329001
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55772910
116Cocaine addiction_Homo sapiens_hsa050300.54579731
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54024149
118Wnt signaling pathway_Homo sapiens_hsa043100.53512393
119Rap1 signaling pathway_Homo sapiens_hsa040150.53228791
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52919428
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.52554959
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.52463673
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51550370
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51173050
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51133634
126Dorso-ventral axis formation_Homo sapiens_hsa043200.50558236
127Circadian entrainment_Homo sapiens_hsa047130.50252573
128AMPK signaling pathway_Homo sapiens_hsa041520.50168551
129Choline metabolism in cancer_Homo sapiens_hsa052310.49961533
130MAPK signaling pathway_Homo sapiens_hsa040100.49317847
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.49295785
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49013132
133Salmonella infection_Homo sapiens_hsa051320.48509110
134Renin secretion_Homo sapiens_hsa049240.47876557
135GnRH signaling pathway_Homo sapiens_hsa049120.47123601
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45442954
137Ras signaling pathway_Homo sapiens_hsa040140.45232607
138Oxytocin signaling pathway_Homo sapiens_hsa049210.44495718
139Cholinergic synapse_Homo sapiens_hsa047250.42412914
140ErbB signaling pathway_Homo sapiens_hsa040120.35888948

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