SRSF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.77084126
2DNA double-strand break processing (GO:0000729)5.30392572
3heterochromatin organization (GO:0070828)5.14680380
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.55287456
5nuclear pore organization (GO:0006999)4.44174638
6replication fork processing (GO:0031297)4.42490520
7* negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.24168417
8nuclear pore complex assembly (GO:0051292)4.15936286
9DNA strand elongation involved in DNA replication (GO:0006271)4.15668998
10protein localization to kinetochore (GO:0034501)4.07248267
11ribosomal small subunit assembly (GO:0000028)4.06940514
12response to pheromone (GO:0019236)4.06853221
13viral transcription (GO:0019083)4.06414464
14DNA replication initiation (GO:0006270)4.02877398
15* negative regulation of RNA splicing (GO:0033119)4.02495387
16translational termination (GO:0006415)3.98631806
17DNA strand elongation (GO:0022616)3.90796056
18histone H2A acetylation (GO:0043968)3.89406121
19translesion synthesis (GO:0019985)3.80446517
20folic acid-containing compound biosynthetic process (GO:0009396)3.75250622
21DNA replication-dependent nucleosome assembly (GO:0006335)3.72369200
22DNA replication-dependent nucleosome organization (GO:0034723)3.72369200
23protein K6-linked ubiquitination (GO:0085020)3.68214133
24regulation of nuclear cell cycle DNA replication (GO:0033262)3.64789821
25maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.64137412
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63728683
27DNA duplex unwinding (GO:0032508)3.63028341
28* negative regulation of mRNA processing (GO:0050686)3.62349763
29telomere maintenance via semi-conservative replication (GO:0032201)3.62075459
30regulation of DNA endoreduplication (GO:0032875)3.59831354
31maturation of SSU-rRNA (GO:0030490)3.59728707
32DNA geometric change (GO:0032392)3.58522859
33translational elongation (GO:0006414)3.56282084
34mitotic nuclear envelope disassembly (GO:0007077)3.52038769
35formation of translation preinitiation complex (GO:0001731)3.51527365
36translational initiation (GO:0006413)3.50312680
37ribosomal large subunit biogenesis (GO:0042273)3.46734262
38mitotic sister chromatid cohesion (GO:0007064)3.46085073
39IMP biosynthetic process (GO:0006188)3.40883511
40protein localization to chromosome, centromeric region (GO:0071459)3.40031544
41synapsis (GO:0007129)3.39303675
42lactate metabolic process (GO:0006089)3.35120768
43SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.34448911
44negative regulation of histone methylation (GO:0031061)3.33621250
45membrane disassembly (GO:0030397)3.32637779
46nuclear envelope disassembly (GO:0051081)3.32637779
47* negative regulation of mRNA metabolic process (GO:1903312)3.30954598
48IMP metabolic process (GO:0046040)3.27259284
49pre-miRNA processing (GO:0031054)3.26857896
50* mRNA splicing, via spliceosome (GO:0000398)3.26676922
51* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.26676922
52dosage compensation (GO:0007549)3.26064328
53presynaptic membrane assembly (GO:0097105)3.25653675
54protein targeting to ER (GO:0045047)3.25306471
55regulation of sister chromatid cohesion (GO:0007063)3.24672455
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23764650
57cotranslational protein targeting to membrane (GO:0006613)3.21771498
58nucleobase biosynthetic process (GO:0046112)3.21742264
59mitotic recombination (GO:0006312)3.21659174
60* RNA splicing, via transesterification reactions (GO:0000375)3.21193283
61chromatin remodeling at centromere (GO:0031055)3.21135794
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.19472826
63recombinational repair (GO:0000725)3.18021747
64double-strand break repair via homologous recombination (GO:0000724)3.16923534
65regulation of histone H3-K9 methylation (GO:0051570)3.16269375
66viral life cycle (GO:0019058)3.16160081
67mRNA stabilization (GO:0048255)3.15791211
68RNA stabilization (GO:0043489)3.15791211
69histone exchange (GO:0043486)3.15727806
70respiratory chain complex IV assembly (GO:0008535)3.14164612
71somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13618607
72somatic hypermutation of immunoglobulin genes (GO:0016446)3.13618607
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11001198
74regulation of meiosis I (GO:0060631)3.10716771
75telomere maintenance via recombination (GO:0000722)3.09947435
76regulation of hexokinase activity (GO:1903299)3.09453999
77regulation of glucokinase activity (GO:0033131)3.09453999
78protein localization to endoplasmic reticulum (GO:0070972)3.09223841
79regulation of translation, ncRNA-mediated (GO:0045974)3.08624266
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08624266
81negative regulation of translation, ncRNA-mediated (GO:0040033)3.08624266
82ribosome assembly (GO:0042255)3.08587625
83* alternative mRNA splicing, via spliceosome (GO:0000380)3.08484521
84DNA topological change (GO:0006265)3.06683517
85CENP-A containing nucleosome assembly (GO:0034080)3.06251792
863-UTR-mediated mRNA stabilization (GO:0070935)3.05014699
87kinetochore assembly (GO:0051382)3.03457686
88cellular protein complex disassembly (GO:0043624)3.01367198
89regulation of translational fidelity (GO:0006450)3.00824134
90mitotic chromosome condensation (GO:0007076)3.00214066
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99848920
92kinetochore organization (GO:0051383)2.98831364
93protein complex disassembly (GO:0043241)2.98320969
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98182432
95histone H2A monoubiquitination (GO:0035518)2.97886425
96limb bud formation (GO:0060174)2.97235419
97proteasome assembly (GO:0043248)2.96398171
98nuclear-transcribed mRNA catabolic process (GO:0000956)2.96298341
99pore complex assembly (GO:0046931)2.96107712
100* termination of RNA polymerase II transcription (GO:0006369)2.96099725
101regulation of RNA export from nucleus (GO:0046831)2.95976812
102ribosomal small subunit biogenesis (GO:0042274)2.94943115
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.94415390
104regulation of mitotic spindle checkpoint (GO:1903504)2.94415390
105chromatin assembly or disassembly (GO:0006333)2.93014130
106DNA replication checkpoint (GO:0000076)2.92257414
107sister chromatid segregation (GO:0000819)2.91354943
108ribonucleoprotein complex biogenesis (GO:0022613)2.90974857
109DNA replication-independent nucleosome organization (GO:0034724)2.90336969
110DNA replication-independent nucleosome assembly (GO:0006336)2.90336969
111mitotic G1 DNA damage checkpoint (GO:0031571)2.88472934
112DNA catabolic process, exonucleolytic (GO:0000738)2.88226614
113postreplication repair (GO:0006301)2.88005496
114water-soluble vitamin biosynthetic process (GO:0042364)2.86465827
115spindle assembly checkpoint (GO:0071173)2.85832392
116regulation of DNA damage checkpoint (GO:2000001)2.83658534
117DNA conformation change (GO:0071103)2.83136280
118telomere maintenance via telomere lengthening (GO:0010833)2.82966810
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82242611
120spliceosomal tri-snRNP complex assembly (GO:0000244)2.81208876
121RNA catabolic process (GO:0006401)2.81169421
122negative regulation of transcription regulatory region DNA binding (GO:2000678)2.80840951
123mitotic spindle assembly checkpoint (GO:0007094)2.80619241
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.79742643
125mRNA catabolic process (GO:0006402)2.79203220
126negative regulation of chromosome segregation (GO:0051985)2.78650343
127somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78212451
128somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.78212451
129isotype switching (GO:0045190)2.78212451
130ribosome biogenesis (GO:0042254)2.78037517
131cytochrome complex assembly (GO:0017004)2.77672549
132presynaptic membrane organization (GO:0097090)2.77531068
133ATP-dependent chromatin remodeling (GO:0043044)2.76125085
134protein-DNA complex disassembly (GO:0032986)2.76043787
135nucleosome disassembly (GO:0006337)2.76043787
136regulation of helicase activity (GO:0051095)2.75843681
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.75677391
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.75677391
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.75677391
140negative regulation of sister chromatid segregation (GO:0033046)2.75677391
141negative regulation of DNA recombination (GO:0045910)2.75632051
142macromolecular complex disassembly (GO:0032984)2.75278217
143regulation of centriole replication (GO:0046599)2.74642459
144positive regulation of protein autophosphorylation (GO:0031954)2.73637693
145prenylation (GO:0097354)2.73388261
146protein prenylation (GO:0018342)2.73388261
147viral mRNA export from host cell nucleus (GO:0046784)2.71646601
148fucose catabolic process (GO:0019317)2.71333753
149L-fucose metabolic process (GO:0042354)2.71333753
150L-fucose catabolic process (GO:0042355)2.71333753
151platelet dense granule organization (GO:0060155)2.70919143
152cullin deneddylation (GO:0010388)2.70708872
153keratinocyte development (GO:0003334)2.69865018
154non-recombinational repair (GO:0000726)2.68625834
155double-strand break repair via nonhomologous end joining (GO:0006303)2.68625834
156neural tube formation (GO:0001841)2.68134597
157protein K11-linked deubiquitination (GO:0035871)2.66646279
158resolution of meiotic recombination intermediates (GO:0000712)2.62226150
159microtubule depolymerization (GO:0007019)2.58819344
160female gonad development (GO:0008585)2.57632272
161acrosome assembly (GO:0001675)2.57503628
162response to X-ray (GO:0010165)2.57397292
163regulation of telomere maintenance (GO:0032204)2.56851357
164L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54998895
165kidney morphogenesis (GO:0060993)2.53777247
166inositol phosphate catabolic process (GO:0071545)2.53464535
167telomere maintenance via telomerase (GO:0007004)2.52972792
168cornea development in camera-type eye (GO:0061303)2.52703002
169spindle checkpoint (GO:0031577)2.50959504
170branched-chain amino acid catabolic process (GO:0009083)2.50106933
171zinc ion transport (GO:0006829)2.49582884
172intraciliary transport (GO:0042073)2.48390178
173atrial cardiac muscle cell action potential (GO:0086014)2.48243785
174double-strand break repair (GO:0006302)2.48048146
175sister chromatid cohesion (GO:0007062)2.47146664
176attachment of spindle microtubules to kinetochore (GO:0008608)2.44961271
177mitotic spindle checkpoint (GO:0071174)2.43418748
178metaphase plate congression (GO:0051310)2.42012271
179cilium morphogenesis (GO:0060271)2.38600448
180exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38157190
181centrosome organization (GO:0051297)2.37405121
182histone mRNA catabolic process (GO:0071044)2.37341061
183rRNA methylation (GO:0031167)2.36746573
184protein deneddylation (GO:0000338)2.35753481
185mitochondrial RNA metabolic process (GO:0000959)2.35543464
186regulation of timing of cell differentiation (GO:0048505)2.35052350
187DNA deamination (GO:0045006)2.34943448
188pyrimidine nucleobase catabolic process (GO:0006208)2.33527475
189negative regulation of JUN kinase activity (GO:0043508)2.33303054
190regulation of non-canonical Wnt signaling pathway (GO:2000050)2.33137983
191regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.32947493
192nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.32048434
193somite development (GO:0061053)2.31215196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.94146532
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.21308903
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.91368873
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44130684
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41367907
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.19936008
7ZNF274_21170338_ChIP-Seq_K562_Hela3.14747556
8MYC_22102868_ChIP-Seq_BL_Human2.91812423
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.85866909
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80737269
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79025791
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78121813
13GBX2_23144817_ChIP-Seq_PC3_Human2.66729561
14VDR_22108803_ChIP-Seq_LS180_Human2.65222394
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64262262
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61530440
17FUS_26573619_Chip-Seq_HEK293_Human2.58265531
18EWS_26573619_Chip-Seq_HEK293_Human2.49253708
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45020822
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44844975
21XRN2_22483619_ChIP-Seq_HELA_Human2.28664586
22P300_19829295_ChIP-Seq_ESCs_Human2.25639389
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25536113
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25371960
25IGF1R_20145208_ChIP-Seq_DFB_Human2.19241107
26TAF15_26573619_Chip-Seq_HEK293_Human2.14810791
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.13051541
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09008686
29CIITA_25753668_ChIP-Seq_RAJI_Human2.01271182
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99484451
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.97409423
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95968049
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.94024999
34AR_21909140_ChIP-Seq_LNCAP_Human1.93560801
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88455591
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87353030
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87019640
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.81554889
39VDR_21846776_ChIP-Seq_THP-1_Human1.81324480
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79955441
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79938303
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.79318448
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77472672
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74023120
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68513517
46CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67987920
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.67566390
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66658118
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66203952
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65512232
51VDR_23849224_ChIP-Seq_CD4+_Human1.64807326
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62684128
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60906024
54KDM5A_27292631_Chip-Seq_BREAST_Human1.59102575
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58581194
56TTF2_22483619_ChIP-Seq_HELA_Human1.58329942
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.57865887
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57463469
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57214029
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56227814
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56120343
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.55830169
63ER_23166858_ChIP-Seq_MCF-7_Human1.54756121
64SMAD4_21799915_ChIP-Seq_A2780_Human1.54750490
65BCAT_22108803_ChIP-Seq_LS180_Human1.54638496
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53152667
67FOXP3_21729870_ChIP-Seq_TREG_Human1.52553183
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51319763
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51194292
70GABP_19822575_ChIP-Seq_HepG2_Human1.50228957
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49981636
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48669168
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45943501
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45605194
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45271244
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44586146
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43710831
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.43621201
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43312770
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42416364
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41078416
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40782876
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40748859
84DCP1A_22483619_ChIP-Seq_HELA_Human1.40098594
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38234930
86AR_25329375_ChIP-Seq_VCAP_Human1.36912996
87CBP_20019798_ChIP-Seq_JUKART_Human1.35574109
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35574109
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.34987698
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.34492576
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34488232
92TFEB_21752829_ChIP-Seq_HELA_Human1.34375849
93ZNF263_19887448_ChIP-Seq_K562_Human1.33951550
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33119686
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32964610
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32319640
97TCF7_22412390_ChIP-Seq_EML_Mouse1.32029265
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.31989576
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31797141
100STAT3_23295773_ChIP-Seq_U87_Human1.30812996
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30437822
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.30005540
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.28814630
104MYC_18940864_ChIP-ChIP_HL60_Human1.28286045
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28188496
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27683937
107KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27499596
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25505976
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25091749
110TCF4_22108803_ChIP-Seq_LS180_Human1.25036989
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.24845887
112EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24167629
113SOX2_19829295_ChIP-Seq_ESCs_Human1.24163370
114NANOG_19829295_ChIP-Seq_ESCs_Human1.24163370
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21884517
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21719281
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21470937
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21283105
119TCF4_23295773_ChIP-Seq_U87_Human1.20614301
120P53_22387025_ChIP-Seq_ESCs_Mouse1.18513592
121UTX_26944678_Chip-Seq_JUKART_Human1.18268273
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.17610182
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17592009
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16505865
125NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15761544
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15671626
127* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15322407
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14387117
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14281295
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.13772852
131ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13305443
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13142405
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13142405
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11469676
135SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10924190
136HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10797493
137KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10407884
138CHD1_26751641_Chip-Seq_LNCaP_Human1.10253944
139CDX2_22108803_ChIP-Seq_LS180_Human1.08957688
140ELK3_25401928_ChIP-Seq_HUVEC_Human1.08762813
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08575597
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08453103
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08275235
144E2F1_18555785_Chip-Seq_ESCs_Mouse1.08206671
145RUNX2_22187159_ChIP-Seq_PCA_Human1.08192121
146OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08116590
147CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08042901
148ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07773342
149ELK1_19687146_ChIP-ChIP_HELA_Human1.07606025
150ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06891439
151MAF_26560356_Chip-Seq_TH1_Human1.05984155
152SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05892528
153P300_18555785_Chip-Seq_ESCs_Mouse1.05653702
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05533993
155CMYC_18555785_Chip-Seq_ESCs_Mouse1.03528104
156TP53_22573176_ChIP-Seq_HFKS_Human1.03197694
157FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02910624
158FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02682242
159NANOG_21062744_ChIP-ChIP_HESCs_Human1.02228948
160SMAD4_21741376_ChIP-Seq_EPCs_Human1.01846281
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00548893
162TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99761412
163STAT3_18555785_Chip-Seq_ESCs_Mouse0.99287472
164CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99143138
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.99056266
166SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97516211
167KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96992952
168SALL1_21062744_ChIP-ChIP_HESCs_Human0.96063730
169KDM2B_26808549_Chip-Seq_DND41_Human0.96019071
170STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95974228
171GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95797913
172RNF2_27304074_Chip-Seq_NSC_Mouse0.95615142
173CLOCK_20551151_ChIP-Seq_293T_Human0.94459340
174FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93388455
175ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93232374
176BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92944936
177MYB_26560356_Chip-Seq_TH1_Human0.92726250
178PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91204330
179TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90716754
180NCOR1_26117541_ChIP-Seq_K562_Human0.90571841
181SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90239130
182SPI1_23547873_ChIP-Seq_NB4_Human0.89296758
183TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88755575

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.50755015
2MP0010094_abnormal_chromosome_stability3.31965374
3MP0004957_abnormal_blastocyst_morpholog3.28983334
4MP0003111_abnormal_nucleus_morphology3.26043343
5MP0002102_abnormal_ear_morphology3.21537034
6MP0005367_renal/urinary_system_phenotyp3.05666968
7MP0000516_abnormal_urinary_system3.05666968
8MP0008877_abnormal_DNA_methylation3.03155905
9MP0010352_gastrointestinal_tract_polyps2.99937714
10MP0003077_abnormal_cell_cycle2.96509991
11MP0003787_abnormal_imprinting2.77044402
12MP0000372_irregular_coat_pigmentation2.67843044
13MP0008057_abnormal_DNA_replication2.61349322
14MP0002396_abnormal_hematopoietic_system2.43576520
15MP0000569_abnormal_digit_pigmentation2.34142702
16MP0001730_embryonic_growth_arrest2.33524403
17MP0003195_calcinosis2.32845003
18MP0003123_paternal_imprinting2.25542481
19MP0003705_abnormal_hypodermis_morpholog2.22881989
20MP0002837_dystrophic_cardiac_calcinosis2.22114934
21MP0000537_abnormal_urethra_morphology2.16048306
22MP0008007_abnormal_cellular_replicative2.09293065
23MP0005076_abnormal_cell_differentiation2.06657557
24MP0004808_abnormal_hematopoietic_stem2.00184963
25MP0010030_abnormal_orbit_morphology1.98969836
26MP0006072_abnormal_retinal_apoptosis1.98714489
27MP0008058_abnormal_DNA_repair1.98570910
28MP0000350_abnormal_cell_proliferation1.97711765
29MP0003718_maternal_effect1.94989936
30MP0008932_abnormal_embryonic_tissue1.92745028
31MP0006054_spinal_hemorrhage1.92430638
32MP0006292_abnormal_olfactory_placode1.83448258
33MP0004197_abnormal_fetal_growth/weight/1.81739140
34MP0005551_abnormal_eye_electrophysiolog1.79246394
35MP0005075_abnormal_melanosome_morpholog1.78716588
36MP0005253_abnormal_eye_physiology1.76923555
37MP0002736_abnormal_nociception_after1.76856495
38MP0001697_abnormal_embryo_size1.76286610
39MP0001849_ear_inflammation1.76021860
40MP0003567_abnormal_fetal_cardiomyocyte1.75625390
41MP0002084_abnormal_developmental_patter1.72617842
42MP0010307_abnormal_tumor_latency1.69000892
43MP0002751_abnormal_autonomic_nervous1.68556071
44MP0005380_embryogenesis_phenotype1.67854965
45MP0001672_abnormal_embryogenesis/_devel1.67854965
46MP0009278_abnormal_bone_marrow1.65826294
47MP0002085_abnormal_embryonic_tissue1.65022291
48MP0005646_abnormal_pituitary_gland1.64101075
49MP0002254_reproductive_system_inflammat1.62825631
50MP0000490_abnormal_crypts_of1.60924425
51MP0003984_embryonic_growth_retardation1.60620993
52MP0002080_prenatal_lethality1.60037060
53MP0002088_abnormal_embryonic_growth/wei1.59346704
54MP0002086_abnormal_extraembryonic_tissu1.56464291
55MP0003136_yellow_coat_color1.55671405
56MP0003121_genomic_imprinting1.49815340
57MP0003880_abnormal_central_pattern1.49115163
58MP0001968_abnormal_touch/_nociception1.43228205
59MP0001485_abnormal_pinna_reflex1.43058312
60MP0008872_abnormal_physiological_respon1.41263943
61MP0000733_abnormal_muscle_development1.39214142
62MP0003119_abnormal_digestive_system1.34539241
63MP0001293_anophthalmia1.32728469
64MP0003763_abnormal_thymus_physiology1.30535307
65MP0000428_abnormal_craniofacial_morphol1.29892573
66MP0002090_abnormal_vision1.29512079
67MP0005174_abnormal_tail_pigmentation1.29316438
68MP0009053_abnormal_anal_canal1.28279842
69MP0000631_abnormal_neuroendocrine_gland1.27824596
70MP0000703_abnormal_thymus_morphology1.27672387
71MP0001545_abnormal_hematopoietic_system1.27326171
72MP0005397_hematopoietic_system_phenotyp1.27326171
73MP0009697_abnormal_copulation1.26763672
74MP0010234_abnormal_vibrissa_follicle1.25999305
75MP0001984_abnormal_olfaction1.25869200
76MP0001529_abnormal_vocalization1.23762328
77MP0004215_abnormal_myocardial_fiber1.23578543
78MP0000427_abnormal_hair_cycle1.23443038
79MP0000313_abnormal_cell_death1.21528879
80MP0009780_abnormal_chondrocyte_physiolo1.19946933
81MP0002019_abnormal_tumor_incidence1.19385068
82MP0003300_gastrointestinal_ulcer1.19335152
83MP0003890_abnormal_embryonic-extraembry1.17254631
84MP0004147_increased_porphyrin_level1.17067034
85MP0003283_abnormal_digestive_organ1.16551132
86MP0009672_abnormal_birth_weight1.15360312
87MP0008789_abnormal_olfactory_epithelium1.14399181
88MP0005408_hypopigmentation1.14110601
89MP0005645_abnormal_hypothalamus_physiol1.13676056
90MP0002166_altered_tumor_susceptibility1.11806068
91MP0003122_maternal_imprinting1.10651937
92MP0001929_abnormal_gametogenesis1.09852330
93MP0003315_abnormal_perineum_morphology1.08141429
94MP0005220_abnormal_exocrine_pancreas1.07546782
95MP0000647_abnormal_sebaceous_gland1.07040697
96MP0000465_gastrointestinal_hemorrhage1.06996565
97MP0001324_abnormal_eye_pigmentation1.05137471
98MP0001486_abnormal_startle_reflex1.04763853
99MP0003566_abnormal_cell_adhesion1.04498234
100MP0005187_abnormal_penis_morphology1.04175436
101MP0002398_abnormal_bone_marrow1.03924995
102MP0002233_abnormal_nose_morphology1.03845386
103MP0004885_abnormal_endolymph1.03793850
104MP0002638_abnormal_pupillary_reflex1.03691632
105MP0003755_abnormal_palate_morphology1.03143451
106MP0003937_abnormal_limbs/digits/tail_de1.02730378
107MP0009703_decreased_birth_body1.02593416
108MP0005395_other_phenotype1.02588921
109MP0005248_abnormal_Harderian_gland1.02393279
110MP0002092_abnormal_eye_morphology1.01872232
111MP0004264_abnormal_extraembryonic_tissu1.00492418
112MP0000653_abnormal_sex_gland0.99892737
113MP0005171_absent_coat_pigmentation0.98440565
114MP0003935_abnormal_craniofacial_develop0.98339405
115MP0001873_stomach_inflammation0.96753926
116MP0009046_muscle_twitch0.95740131
117MP0005389_reproductive_system_phenotype0.95550524
118MP0002722_abnormal_immune_system0.95341484
119MP0003115_abnormal_respiratory_system0.95204911
120MP0000538_abnormal_urinary_bladder0.95070508
121MP0002095_abnormal_skin_pigmentation0.94616624
122MP0005379_endocrine/exocrine_gland_phen0.93809010
123MP0005391_vision/eye_phenotype0.93160953
124MP0004133_heterotaxia0.91656594
125MP0001915_intracranial_hemorrhage0.90209448
126MP0002932_abnormal_joint_morphology0.88549166
127MP0009333_abnormal_splenocyte_physiolog0.88463711
128MP0002111_abnormal_tail_morphology0.87885263
129MP0003698_abnormal_male_reproductive0.87286985
130MP0002925_abnormal_cardiovascular_devel0.86608152
131MP0005023_abnormal_wound_healing0.86416608
132MP0002163_abnormal_gland_morphology0.85848612
133MP0000477_abnormal_intestine_morphology0.85016948
134MP0002160_abnormal_reproductive_system0.84876697
135MP0002653_abnormal_ependyma_morphology0.83987361
136MP0002009_preneoplasia0.83358341
137MP0000778_abnormal_nervous_system0.83316587
138MP0005084_abnormal_gallbladder_morpholo0.83049684
139MP0003646_muscle_fatigue0.82762920
140MP0003942_abnormal_urinary_system0.82347490
141MP0001119_abnormal_female_reproductive0.82202679
142MP0000689_abnormal_spleen_morphology0.81838659
143MP0006035_abnormal_mitochondrial_morpho0.81789332
144MP0005195_abnormal_posterior_eye0.81632745
145MP0000015_abnormal_ear_pigmentation0.81296643
146MP0000613_abnormal_salivary_gland0.80208222
147MP0001764_abnormal_homeostasis0.79779282
148MP0002938_white_spotting0.78675235
149MP0002697_abnormal_eye_size0.77926810
150MP0003786_premature_aging0.77670067
151MP0001177_atelectasis0.76587577
152MP0004924_abnormal_behavior0.76237564
153MP0005386_behavior/neurological_phenoty0.76237564
154MP0001919_abnormal_reproductive_system0.75604060
155MP0000383_abnormal_hair_follicle0.74979462
156MP0003137_abnormal_impulse_conducting0.74412992
157MP0002234_abnormal_pharynx_morphology0.74260848
158MP0000049_abnormal_middle_ear0.73821494
159MP0000377_abnormal_hair_follicle0.73387352
160MP0002429_abnormal_blood_cell0.73240016
161MP0001145_abnormal_male_reproductive0.73180427
162MP0010678_abnormal_skin_adnexa0.72834784
163MP0001286_abnormal_eye_development0.72393701
164MP0002282_abnormal_trachea_morphology0.71805370
165MP0000432_abnormal_head_morphology0.69898788
166MP0002210_abnormal_sex_determination0.68820316
167MP0003943_abnormal_hepatobiliary_system0.68064639
168MP0000266_abnormal_heart_morphology0.67451360
169MP0002877_abnormal_melanocyte_morpholog0.66002472
170MP0000858_altered_metastatic_potential0.64849760
171MP0002006_tumorigenesis0.63932004
172MP0005384_cellular_phenotype0.63720330
173MP0000685_abnormal_immune_system0.63168187
174MP0010630_abnormal_cardiac_muscle0.62888308

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.09522157
2Medulloblastoma (HP:0002885)3.85578344
3Colon cancer (HP:0003003)3.73987182
4Abnormality of cells of the erythroid lineage (HP:0012130)3.73602400
5Abnormal number of erythroid precursors (HP:0012131)3.64789935
6Pancreatic fibrosis (HP:0100732)3.55005383
7Pancreatic cysts (HP:0001737)3.54801214
8Short 4th metacarpal (HP:0010044)3.40006702
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.40006702
10True hermaphroditism (HP:0010459)3.35556731
11Intestinal atresia (HP:0011100)3.18833873
12Selective tooth agenesis (HP:0001592)3.17775781
13Abnormality of the labia minora (HP:0012880)3.16277977
14Abnormality of midbrain morphology (HP:0002418)3.15667431
15Molar tooth sign on MRI (HP:0002419)3.15667431
16Reticulocytopenia (HP:0001896)3.14366670
17Abnormality of the astrocytes (HP:0100707)2.98376052
18Astrocytoma (HP:0009592)2.98376052
19Hyperacusis (HP:0010780)2.86879681
20Increased nuchal translucency (HP:0010880)2.80232311
21Neoplasm of the adrenal cortex (HP:0100641)2.74664494
22Renal duplication (HP:0000075)2.72698545
23Abnormality of the 4th metacarpal (HP:0010012)2.66517634
24Volvulus (HP:0002580)2.65145191
25Nephronophthisis (HP:0000090)2.65079212
26Methylmalonic acidemia (HP:0002912)2.64148863
27Thrombocytosis (HP:0001894)2.59863993
28Meckel diverticulum (HP:0002245)2.59366879
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.59193797
30Hypothermia (HP:0002045)2.58820318
31Basal cell carcinoma (HP:0002671)2.58462901
32Abnormality of the ileum (HP:0001549)2.54635032
33Proximal placement of thumb (HP:0009623)2.51758456
34Glioma (HP:0009733)2.49710402
35Neoplasm of the oral cavity (HP:0100649)2.49311346
36Neoplasm of striated muscle (HP:0009728)2.48831771
37Heterotopia (HP:0002282)2.46472303
38Long eyelashes (HP:0000527)2.45057510
39Chronic hepatic failure (HP:0100626)2.43296667
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.40857736
41Deviation of the thumb (HP:0009603)2.36044711
42Abnormality of the renal medulla (HP:0100957)2.34563883
43Abnormality of the renal cortex (HP:0011035)2.34299063
44Aqueductal stenosis (HP:0002410)2.33871414
45Pancreatic islet-cell hyperplasia (HP:0004510)2.30999756
46Thyroiditis (HP:0100646)2.30767764
47Abolished electroretinogram (ERG) (HP:0000550)2.28934285
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26735796
49Medial flaring of the eyebrow (HP:0010747)2.24165444
50Birth length less than 3rd percentile (HP:0003561)2.22671208
51Abnormality of the preputium (HP:0100587)2.19051762
52Congenital stationary night blindness (HP:0007642)2.18667768
53Abnormality of the pancreatic islet cells (HP:0006476)2.16815639
54Abnormality of endocrine pancreas physiology (HP:0012093)2.16815639
55Aplastic anemia (HP:0001915)2.15925631
56Biliary tract neoplasm (HP:0100574)2.14805772
57Abnormal lung lobation (HP:0002101)2.13408974
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.13254082
59Hypoplasia of the fovea (HP:0007750)2.13254082
60Prominent nose (HP:0000448)2.12549213
61Rhabdomyosarcoma (HP:0002859)2.12471398
62Atresia of the external auditory canal (HP:0000413)2.12419289
63Small hand (HP:0200055)2.12177083
64Ankle contracture (HP:0006466)2.12127674
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11991471
66Renovascular hypertension (HP:0100817)2.11114959
67Renal hypoplasia (HP:0000089)2.10902050
68Pallor (HP:0000980)2.10538109
69Macroorchidism (HP:0000053)2.09546051
70Hyperventilation (HP:0002883)2.09250577
71Chromsome breakage (HP:0040012)2.08931077
72Sloping forehead (HP:0000340)2.08110765
73Cystic liver disease (HP:0006706)2.07903329
74Patellar aplasia (HP:0006443)2.06956269
75Neoplasm of the heart (HP:0100544)2.06067170
76Disinhibition (HP:0000734)2.05794002
77Renal cortical cysts (HP:0000803)2.05702871
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.05690685
79Short 1st metacarpal (HP:0010034)2.05690685
80Methylmalonic aciduria (HP:0012120)2.05062954
81Overriding aorta (HP:0002623)2.05058574
82Neoplasm of the pancreas (HP:0002894)2.04436796
83Abnormality of the duodenum (HP:0002246)2.04415353
84Elfin facies (HP:0004428)2.04220973
85Abnormality of vitamin B metabolism (HP:0004340)2.03995762
86Gastrointestinal carcinoma (HP:0002672)2.03774797
87Malignant gastrointestinal tract tumors (HP:0006749)2.03774797
88Cutis marmorata (HP:0000965)2.02675970
89Hyperglycinemia (HP:0002154)2.01536090
90Angiofibromas (HP:0010615)2.01330159
91Adenoma sebaceum (HP:0009720)2.01330159
92Abnormality of the fingertips (HP:0001211)2.00379424
93Gastrointestinal atresia (HP:0002589)2.00125456
94Postaxial hand polydactyly (HP:0001162)2.00115804
95Abnormal number of incisors (HP:0011064)1.99942184
96Fibrous tissue neoplasm (HP:0012316)1.99500739
97Skin tags (HP:0010609)1.97765831
98Aplasia/Hypoplasia of the patella (HP:0006498)1.97571232
99Broad palm (HP:0001169)1.97427268
100Increased density of long bones (HP:0006392)1.96915657
101Bowel diverticulosis (HP:0005222)1.96748195
102Pendular nystagmus (HP:0012043)1.95549645
103Small intestinal stenosis (HP:0012848)1.95128250
104Duodenal stenosis (HP:0100867)1.95128250
105Genital tract atresia (HP:0001827)1.93275435
106Hypoproteinemia (HP:0003075)1.93261462
107Hypoglycemic seizures (HP:0002173)1.92807072
108Neoplasm of the adrenal gland (HP:0100631)1.92296333
109Fibroma (HP:0010614)1.92250666
110Cerebral aneurysm (HP:0004944)1.91864479
111Gaze-evoked nystagmus (HP:0000640)1.91794441
112High pitched voice (HP:0001620)1.90144929
113Postaxial foot polydactyly (HP:0001830)1.90114795
114Preaxial hand polydactyly (HP:0001177)1.89847337
115Progressive inability to walk (HP:0002505)1.89257375
116Male pseudohermaphroditism (HP:0000037)1.89096554
117Missing ribs (HP:0000921)1.89072467
118Ectopic kidney (HP:0000086)1.88974194
1193-Methylglutaconic aciduria (HP:0003535)1.88328656
120Abnormality of chromosome stability (HP:0003220)1.88108675
121Hyperinsulinemic hypoglycemia (HP:0000825)1.88071824
122Shallow orbits (HP:0000586)1.87126263
123Rectal prolapse (HP:0002035)1.86399090
124Myelodysplasia (HP:0002863)1.85060639
125Sclerocornea (HP:0000647)1.84883007
126Attenuation of retinal blood vessels (HP:0007843)1.84567610
127Supernumerary bones of the axial skeleton (HP:0009144)1.84526689
128Bifid tongue (HP:0010297)1.83704887
129Subacute progressive viral hepatitis (HP:0006572)1.83117523
130Progressive muscle weakness (HP:0003323)1.82993316
131Dandy-Walker malformation (HP:0001305)1.82653466
132Hypoglycemic coma (HP:0001325)1.82627767
133Optic nerve hypoplasia (HP:0000609)1.82612018
134Abnormality of methionine metabolism (HP:0010901)1.82553777
135Furrowed tongue (HP:0000221)1.81936924
136Amaurosis fugax (HP:0100576)1.81841355
137Oral leukoplakia (HP:0002745)1.81561162
138High anterior hairline (HP:0009890)1.81468371
139Narrow forehead (HP:0000341)1.81267434
140Breast hypoplasia (HP:0003187)1.80534237
141Abnormality of the fovea (HP:0000493)1.80390025
142Abnormality of the metopic suture (HP:0005556)1.80321583
143Ovarian neoplasm (HP:0100615)1.79595381
144Abnormality of the vitamin B12 metabolism (HP:0004341)1.79292875
145Pseudobulbar signs (HP:0002200)1.78876585
146Fair hair (HP:0002286)1.78211085
147Abnormality of the 1st metacarpal (HP:0010009)1.78181559
148Clubbing of toes (HP:0100760)1.78168457
149Protrusio acetabuli (HP:0003179)1.77807966
150Supernumerary ribs (HP:0005815)1.77396427
151Back pain (HP:0003418)1.76980502
152Anencephaly (HP:0002323)1.76928822
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.76820722
154Bicuspid aortic valve (HP:0001647)1.76772829
155Astigmatism (HP:0000483)1.76710016
156Intestinal polyp (HP:0005266)1.75803235
157Optic nerve coloboma (HP:0000588)1.75465924
158Abnormality of glycine metabolism (HP:0010895)1.74925478
159Abnormality of serine family amino acid metabolism (HP:0010894)1.74925478
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74853145
161Obsessive-compulsive behavior (HP:0000722)1.74240673
162Hyperglycinuria (HP:0003108)1.73696042
163Preauricular skin tag (HP:0000384)1.73587449
164Breast carcinoma (HP:0003002)1.72344811
165Congenital primary aphakia (HP:0007707)1.72271258
16611 pairs of ribs (HP:0000878)1.71469248
167Vaginal atresia (HP:0000148)1.68730754
168Abnormality of serum amino acid levels (HP:0003112)1.68620698
169Hypoplasia of the pons (HP:0012110)1.68540317
170Acute lymphatic leukemia (HP:0006721)1.68273777
171Macrocytic anemia (HP:0001972)1.68247190
172Congenital hepatic fibrosis (HP:0002612)1.68182149
173Progressive macrocephaly (HP:0004481)1.67802267
174Abnormality of the calcaneus (HP:0008364)1.67758822
175Chorioretinal atrophy (HP:0000533)1.67433323
176Gait imbalance (HP:0002141)1.66953712
177Overlapping toe (HP:0001845)1.66524496
178Gonadotropin excess (HP:0000837)1.65900925
179Spastic diplegia (HP:0001264)1.64824649
180Pelvic girdle muscle weakness (HP:0003749)1.62393876
181Neoplasm of the colon (HP:0100273)1.61459283
182Intestinal polyposis (HP:0200008)1.60791147
183Trismus (HP:0000211)1.60762792
184Multiple enchondromatosis (HP:0005701)1.60566731
185Mitral valve prolapse (HP:0001634)1.60439932
186Lymphangioma (HP:0100764)1.59767384
187Facial hemangioma (HP:0000329)1.58294666
188Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58071696
189Degeneration of anterior horn cells (HP:0002398)1.58014420
190Abnormality of the anterior horn cell (HP:0006802)1.58014420
191Neoplasm of the small intestine (HP:0100833)1.55810762
192Uterine neoplasm (HP:0010784)1.54780529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.86098303
2CDC73.12492243
3WEE13.05309453
4NUAK13.04708234
5WNK33.03906012
6TRIM282.99184774
7PKN22.92551701
8MAP3K102.79640390
9EIF2AK12.79611552
10EEF2K2.78808670
11CDK122.72585144
12ACVR1B2.49143440
13ERBB32.45449587
14TNIK2.37258223
15BMPR1B2.35295612
16NEK22.33072141
17MAP4K22.28955275
18PASK2.20651069
19TGFBR12.20635392
20TRIB32.15917368
21RPS6KA42.08174095
22EIF2AK32.02941786
23DYRK32.02842946
24BRD41.99649155
25MAPK131.99592084
26BUB11.91478222
27FLT31.89637704
28RPS6KB21.84494317
29FGFR21.82024879
30MKNK11.80678317
31PLK21.78841166
32ZAK1.77618366
33SCYL21.73483940
34CDK41.68866953
35MST41.68347844
36PAK41.57911371
37STK391.55397057
38CDK71.53552048
39ICK1.49608989
40MKNK21.49585604
41ATR1.48673970
42PNCK1.48220664
43CASK1.47209291
44MAP4K11.44841023
45GRK11.43632753
46SRPK11.42134315
47TAF11.39199375
48PTK61.35990128
49CDK61.34865423
50PAK31.29834346
51OXSR11.28442922
52LRRK21.28273670
53STK101.28247715
54MAP3K81.24923596
55INSRR1.24557127
56ADRBK21.20334402
57TSSK61.18918974
58AURKB1.18897512
59TESK21.17820196
60BCR1.17802133
61TTK1.17071166
62PLK11.15111342
63BRSK21.14336722
64BRSK11.12558792
65NEK11.10112861
66MAP3K111.07413715
67KDR1.07188179
68LATS11.04062989
69STK38L1.03574058
70MTOR1.03377419
71NME21.00439692
72ALK0.98410115
73CHEK10.97949506
74MAP3K40.96768703
75TTN0.96461577
76CSNK1G20.95811029
77EPHA40.95399959
78ERN10.94906231
79PDGFRA0.94754385
80FER0.90990031
81STK40.85301206
82SIK30.85111121
83SIK10.84465159
84EIF2AK20.84265402
85MARK10.84008959
86DYRK1B0.83402316
87BTK0.83136303
88PAK20.79836563
89VRK20.79143198
90ATM0.78903978
91CHEK20.78707868
92DYRK20.77459607
93PINK10.77012862
94CDK20.75430996
95PRKCE0.73393657
96NLK0.73281776
97FGFR10.72585053
98HIPK20.72377695
99STK30.71809597
100ZAP700.70456857
101ERBB20.65656525
102PIM10.63986133
103EPHA20.62358419
104YES10.62020550
105TGFBR20.61825193
106CSNK1A1L0.61789316
107PKN10.59849063
108MAPKAPK30.59648475
109RIPK10.58923054
110AURKA0.56377145
111CDK90.55335820
112MINK10.54347988
113WNK40.53585832
114AKT30.52595030
115GRK60.51000727
116MELK0.50954126
117CSF1R0.50496268
118STK160.49988023
119PRKCG0.49937165
120FGFR40.49916666
121CDK10.46522752
122ILK0.46368376
123MAP2K30.45513292
124NTRK30.44691526
125TLK10.44229965
126RPS6KA10.44066780
127PHKG20.43479802
128PHKG10.43479802
129RPS6KA50.43293462
130ROCK10.42453750
131IRAK10.41857662
132CSNK1G30.41592781
133AKT20.40874853
134VRK10.39969547
135CCNB10.39838529
136CDK30.39653549
137TYRO30.38308112
138CSNK2A20.38179500
139CSNK1G10.38136229
140PLK30.35138947
141PTK2B0.34437080
142PRKDC0.34420489
143PRKD30.34007562
144KIT0.33487529
145CSNK1A10.33292833
146CSNK1D0.33087727
147JAK30.32293296
148PDGFRB0.32280783
149PLK40.31843928
150TESK10.31463937
151PRKCI0.30344386
152SIK20.30019065
153CSNK1E0.29559848
154TIE10.29441972
155MAPK140.29133316
156CDK80.28185893
157ADRBK10.26029485
158IRAK20.24799378
159PRKG10.24029807
160IGF1R0.23852397
161CSNK2A10.23613519
162MARK30.23242156
163ABL10.22723089
164CLK10.22613125

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79216093
2Mismatch repair_Homo sapiens_hsa034303.56691630
3* Spliceosome_Homo sapiens_hsa030403.55601941
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.32623597
5Protein export_Homo sapiens_hsa030603.13907758
6Ribosome_Homo sapiens_hsa030102.97707058
7RNA transport_Homo sapiens_hsa030132.92740500
8Cell cycle_Homo sapiens_hsa041102.75570692
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65984536
10Base excision repair_Homo sapiens_hsa034102.59945624
11Propanoate metabolism_Homo sapiens_hsa006402.52968450
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45667956
13One carbon pool by folate_Homo sapiens_hsa006702.33144237
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31042237
15Nucleotide excision repair_Homo sapiens_hsa034202.13721574
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10467672
17Butanoate metabolism_Homo sapiens_hsa006502.07636356
18mRNA surveillance pathway_Homo sapiens_hsa030152.01904765
19Phototransduction_Homo sapiens_hsa047441.87577799
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84735002
21RNA polymerase_Homo sapiens_hsa030201.82383448
22Homologous recombination_Homo sapiens_hsa034401.81725644
23p53 signaling pathway_Homo sapiens_hsa041151.65471800
24Steroid biosynthesis_Homo sapiens_hsa001001.62384743
25Pyrimidine metabolism_Homo sapiens_hsa002401.61130423
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53682266
27Vitamin B6 metabolism_Homo sapiens_hsa007501.53483874
28Tryptophan metabolism_Homo sapiens_hsa003801.51322288
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49872099
30Fanconi anemia pathway_Homo sapiens_hsa034601.48018069
31Non-homologous end-joining_Homo sapiens_hsa034501.47686602
32Fatty acid elongation_Homo sapiens_hsa000621.47222867
33RNA degradation_Homo sapiens_hsa030181.45446972
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39550713
35Systemic lupus erythematosus_Homo sapiens_hsa053221.39386477
36Chronic myeloid leukemia_Homo sapiens_hsa052201.36619457
37Nitrogen metabolism_Homo sapiens_hsa009101.35025437
38Viral carcinogenesis_Homo sapiens_hsa052031.35006220
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34838937
40Caffeine metabolism_Homo sapiens_hsa002321.32505739
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29759903
42Basal cell carcinoma_Homo sapiens_hsa052171.29495520
43Linoleic acid metabolism_Homo sapiens_hsa005911.25257354
44Antigen processing and presentation_Homo sapiens_hsa046121.23856962
45Ether lipid metabolism_Homo sapiens_hsa005651.23470549
46MicroRNAs in cancer_Homo sapiens_hsa052061.23054270
47HTLV-I infection_Homo sapiens_hsa051661.21433305
48Notch signaling pathway_Homo sapiens_hsa043301.20999079
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17110033
50Small cell lung cancer_Homo sapiens_hsa052221.16409930
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15173578
52* Herpes simplex infection_Homo sapiens_hsa051681.15096302
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14181765
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14035220
55Epstein-Barr virus infection_Homo sapiens_hsa051691.13915576
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13802702
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08194590
58Primary immunodeficiency_Homo sapiens_hsa053401.07163997
59Proteasome_Homo sapiens_hsa030501.06431120
60Colorectal cancer_Homo sapiens_hsa052101.06327480
61Selenocompound metabolism_Homo sapiens_hsa004501.04487106
62Thyroid cancer_Homo sapiens_hsa052161.00665073
63Lysine degradation_Homo sapiens_hsa003100.99062771
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98601972
65beta-Alanine metabolism_Homo sapiens_hsa004100.95780395
66N-Glycan biosynthesis_Homo sapiens_hsa005100.94991408
67Folate biosynthesis_Homo sapiens_hsa007900.94982750
68Regulation of autophagy_Homo sapiens_hsa041400.94888015
69Fatty acid degradation_Homo sapiens_hsa000710.93020886
70Basal transcription factors_Homo sapiens_hsa030220.92053782
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91095426
72Hippo signaling pathway_Homo sapiens_hsa043900.90187352
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89809395
74Retinol metabolism_Homo sapiens_hsa008300.88386001
75Fatty acid metabolism_Homo sapiens_hsa012120.86909480
76Peroxisome_Homo sapiens_hsa041460.85377372
77Oocyte meiosis_Homo sapiens_hsa041140.84423532
78Acute myeloid leukemia_Homo sapiens_hsa052210.84414939
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84367352
80Endometrial cancer_Homo sapiens_hsa052130.80912745
81Proteoglycans in cancer_Homo sapiens_hsa052050.80450459
82Pyruvate metabolism_Homo sapiens_hsa006200.78684026
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77635202
84mTOR signaling pathway_Homo sapiens_hsa041500.76988316
85Viral myocarditis_Homo sapiens_hsa054160.76885907
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.76773479
87Hedgehog signaling pathway_Homo sapiens_hsa043400.76663613
88Non-small cell lung cancer_Homo sapiens_hsa052230.75722256
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75427092
90Bladder cancer_Homo sapiens_hsa052190.74609430
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.74411700
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73871532
93Chemical carcinogenesis_Homo sapiens_hsa052040.73321424
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70699381
95Hepatitis B_Homo sapiens_hsa051610.70593210
96TGF-beta signaling pathway_Homo sapiens_hsa043500.70315834
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70001664
98Taste transduction_Homo sapiens_hsa047420.67595839
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.67067971
100Adherens junction_Homo sapiens_hsa045200.66961148
101B cell receptor signaling pathway_Homo sapiens_hsa046620.66557067
102Purine metabolism_Homo sapiens_hsa002300.64490516
103Nicotine addiction_Homo sapiens_hsa050330.63972076
104Prostate cancer_Homo sapiens_hsa052150.63852976
105Circadian rhythm_Homo sapiens_hsa047100.63789062
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63448738
107Pathways in cancer_Homo sapiens_hsa052000.63377008
108Alcoholism_Homo sapiens_hsa050340.63321601
109Pancreatic cancer_Homo sapiens_hsa052120.61325969
110Glutathione metabolism_Homo sapiens_hsa004800.60627494
111Apoptosis_Homo sapiens_hsa042100.59855134
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.59593141
113Fat digestion and absorption_Homo sapiens_hsa049750.59567248
114Glycerolipid metabolism_Homo sapiens_hsa005610.59385834
115Shigellosis_Homo sapiens_hsa051310.59369552
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58874478
117Metabolic pathways_Homo sapiens_hsa011000.57778734
118Measles_Homo sapiens_hsa051620.57684904
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57671633
120T cell receptor signaling pathway_Homo sapiens_hsa046600.57347999
121Biosynthesis of amino acids_Homo sapiens_hsa012300.56429286
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55994606
123Sulfur metabolism_Homo sapiens_hsa009200.55014246
124Legionellosis_Homo sapiens_hsa051340.54108226
125Olfactory transduction_Homo sapiens_hsa047400.54063092
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53761824
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.53432811
128Sulfur relay system_Homo sapiens_hsa041220.52597577
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.52437262
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.50681710
131Oxidative phosphorylation_Homo sapiens_hsa001900.50521395
132ABC transporters_Homo sapiens_hsa020100.49357453
133Drug metabolism - other enzymes_Homo sapiens_hsa009830.49200423
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.48031864
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47236984
136Collecting duct acid secretion_Homo sapiens_hsa049660.47179046
137Insulin secretion_Homo sapiens_hsa049110.46760443
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46317002
139Histidine metabolism_Homo sapiens_hsa003400.45383912
140Sphingolipid metabolism_Homo sapiens_hsa006000.44878332
141Protein digestion and absorption_Homo sapiens_hsa049740.44767229
142Maturity onset diabetes of the young_Homo sapiens_hsa049500.44590849
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44201121
144VEGF signaling pathway_Homo sapiens_hsa043700.43226154
145Focal adhesion_Homo sapiens_hsa045100.42855238
146Wnt signaling pathway_Homo sapiens_hsa043100.42382321
147Arachidonic acid metabolism_Homo sapiens_hsa005900.42160336
148Hematopoietic cell lineage_Homo sapiens_hsa046400.40455199
149Serotonergic synapse_Homo sapiens_hsa047260.40441498
1502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40142884
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40012021
152Influenza A_Homo sapiens_hsa051640.39257783
153Parkinsons disease_Homo sapiens_hsa050120.38249054
154PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38157575
155Pentose phosphate pathway_Homo sapiens_hsa000300.38019840
156Vitamin digestion and absorption_Homo sapiens_hsa049770.34444189
157AMPK signaling pathway_Homo sapiens_hsa041520.34405048
158Platelet activation_Homo sapiens_hsa046110.34087999
159Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33898140
160Amphetamine addiction_Homo sapiens_hsa050310.33847872
161FoxO signaling pathway_Homo sapiens_hsa040680.33461239
162Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33246900
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32623118
164Toxoplasmosis_Homo sapiens_hsa051450.32167879
165HIF-1 signaling pathway_Homo sapiens_hsa040660.29683614
166Circadian entrainment_Homo sapiens_hsa047130.29540262

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »