SRSF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)4.45736234
2positive regulation of granulocyte differentiation (GO:0030854)3.83830218
3negative regulation of appetite (GO:0032099)3.53945264
4negative regulation of response to food (GO:0032096)3.53945264
5regulation of platelet aggregation (GO:0090330)3.48376021
6regulation of B cell receptor signaling pathway (GO:0050855)3.45671192
7activated T cell proliferation (GO:0050798)3.42259485
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.30107134
9negative T cell selection (GO:0043383)3.25849410
10megakaryocyte development (GO:0035855)3.24899423
11protein neddylation (GO:0045116)3.20518394
12purinergic nucleotide receptor signaling pathway (GO:0035590)3.16426226
13tolerance induction (GO:0002507)3.12034847
14negative regulation of erythrocyte differentiation (GO:0045647)3.09773018
15positive regulation of cAMP-mediated signaling (GO:0043950)3.07750576
16oxygen transport (GO:0015671)3.04811088
17behavioral response to nicotine (GO:0035095)2.97720678
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.95651283
19positive regulation of endothelial cell differentiation (GO:0045603)2.93252358
20positive T cell selection (GO:0043368)2.93026078
21negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.92066408
22negative thymic T cell selection (GO:0045060)2.91353699
23positive regulation of gamma-delta T cell activation (GO:0046645)2.88331595
24positive regulation of Rap GTPase activity (GO:0032854)2.83433764
25protein insertion into membrane (GO:0051205)2.82906878
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80830950
27negative regulation of cell killing (GO:0031342)2.80830950
28regulation of mitochondrial depolarization (GO:0051900)2.79305393
29neutrophil activation involved in immune response (GO:0002283)2.78044249
30regulation of chromatin binding (GO:0035561)2.77490072
31negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.75949764
32regulation of regulatory T cell differentiation (GO:0045589)2.75738432
33angiogenesis involved in wound healing (GO:0060055)2.70817654
34sequestering of actin monomers (GO:0042989)2.69754355
35negative regulation of heart rate (GO:0010459)2.69610807
36B cell receptor signaling pathway (GO:0050853)2.66032560
37regulation of gamma-delta T cell differentiation (GO:0045586)2.64379684
38negative regulation of neurotransmitter transport (GO:0051589)2.64079873
39positive regulation of systemic arterial blood pressure (GO:0003084)2.62174525
40T cell selection (GO:0045058)2.61765695
41regulation of female receptivity (GO:0045924)2.60928570
42negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.59986945
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58592424
44positive regulation of B cell differentiation (GO:0045579)2.57721872
45gas transport (GO:0015669)2.57209733
46positive thymic T cell selection (GO:0045059)2.56791593
47regulation of granulocyte differentiation (GO:0030852)2.55326547
48regulation of Rap GTPase activity (GO:0032317)2.53290462
49thymic T cell selection (GO:0045061)2.51960364
50regulation of cAMP-dependent protein kinase activity (GO:2000479)2.47536208
51response to pheromone (GO:0019236)2.45706848
52leukocyte tethering or rolling (GO:0050901)2.44068716
53termination of G-protein coupled receptor signaling pathway (GO:0038032)2.41471746
54dopamine biosynthetic process (GO:0042416)2.41079674
55purinergic receptor signaling pathway (GO:0035587)2.39903709
56positive regulation of mast cell activation (GO:0033005)2.39640301
57myeloid cell development (GO:0061515)2.39575872
58mitochondrial calcium ion transport (GO:0006851)2.36436085
59amine catabolic process (GO:0009310)2.33994560
60cellular biogenic amine catabolic process (GO:0042402)2.33994560
61adaptation of signaling pathway (GO:0023058)2.33544061
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.33396345
63cell differentiation in hindbrain (GO:0021533)2.33185225
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.31592938
65negative regulation of T cell apoptotic process (GO:0070233)2.30766342
66antigen receptor-mediated signaling pathway (GO:0050851)2.30071954
67protoporphyrinogen IX metabolic process (GO:0046501)2.29759745
68ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.29478999
69positive regulation of vasculogenesis (GO:2001214)2.27967513
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.26585431
71monoamine transport (GO:0015844)2.26414684
72platelet formation (GO:0030220)2.25997988
73regulation of clathrin-mediated endocytosis (GO:2000369)2.25779161
74negative regulation of thymocyte apoptotic process (GO:0070244)2.25404969
75regulation of platelet activation (GO:0010543)2.25233003
76regulation of lipoprotein metabolic process (GO:0050746)2.24297394
77transmission of nerve impulse (GO:0019226)2.24162337
78regulation of hydrogen peroxide metabolic process (GO:0010310)2.22782797
79cytidine deamination (GO:0009972)2.22780850
80cytidine metabolic process (GO:0046087)2.22780850
81cytidine catabolic process (GO:0006216)2.22780850
82regulation of cAMP-mediated signaling (GO:0043949)2.22531562
83receptor recycling (GO:0001881)2.21905903
84regulation of endothelial cell differentiation (GO:0045601)2.21515678
85regulation of erythrocyte differentiation (GO:0045646)2.21332911
86detection of calcium ion (GO:0005513)2.20940361
87embryonic hemopoiesis (GO:0035162)2.20758914
88termination of signal transduction (GO:0023021)2.20578902
89sialylation (GO:0097503)2.20380514
90regulation of response to food (GO:0032095)2.19602653
91positive regulation of macrophage differentiation (GO:0045651)2.18853306
92regulation of B cell differentiation (GO:0045577)2.18826390
93cerebellar Purkinje cell differentiation (GO:0021702)2.18388863
94dopamine transport (GO:0015872)2.18090228
95phosphatidylinositol acyl-chain remodeling (GO:0036149)2.17524524
96regulation of gamma-delta T cell activation (GO:0046643)2.16881190
97neutrophil activation (GO:0042119)2.16568813
98antigen processing and presentation of endogenous antigen (GO:0019883)2.16496397
99cardiolipin metabolic process (GO:0032048)2.16266800
100negative regulation of protein oligomerization (GO:0032460)2.16222301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40454769
2SCL_19346495_ChIP-Seq_HPC-7_Human3.39866381
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99728986
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.71213894
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.62185717
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36831505
7IGF1R_20145208_ChIP-Seq_DFB_Human2.34067865
8GATA1_19941826_ChIP-Seq_K562_Human2.25349497
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20265106
10RUNX_20019798_ChIP-Seq_JUKART_Human2.13758598
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02559454
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00144195
13GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.95799800
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85963309
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85225164
16GATA1_19941827_ChIP-Seq_MEL_Mouse1.77190993
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72723612
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70899953
19GATA2_19941826_ChIP-Seq_K562_Human1.70497490
20LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.64522884
21REST_21632747_ChIP-Seq_MESCs_Mouse1.64203308
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63010406
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57466905
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56677760
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56529449
26KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.56003261
27GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55270210
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53127478
29RNF2_27304074_Chip-Seq_NSC_Mouse1.51981466
30IRF1_19129219_ChIP-ChIP_H3396_Human1.49613850
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.46125129
32TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45255669
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44689367
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42993433
35GATA1_22025678_ChIP-Seq_K562_Human1.42658002
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41000428
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.38166934
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38148058
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35303483
40GATA3_27048872_Chip-Seq_THYMUS_Human1.30466728
41UTX_26944678_Chip-Seq_JUKART_Human1.29784019
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28688705
43MYB_26560356_Chip-Seq_TH2_Human1.28225166
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.25804107
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25011545
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23076516
47TAF15_26573619_Chip-Seq_HEK293_Human1.18219704
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18036575
49AR_21572438_ChIP-Seq_LNCaP_Human1.15668873
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13610794
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.13546318
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12661994
53MAF_26560356_Chip-Seq_TH1_Human1.12303258
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.11369588
55MYC_22102868_ChIP-Seq_BL_Human1.09016443
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09013793
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.07749453
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.04362214
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01436392
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99524778
61GATA2_21666600_ChIP-Seq_HMVEC_Human0.99428513
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98204705
63ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97964231
64MYB_26560356_Chip-Seq_TH1_Human0.96604607
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96004331
66DROSHA_22980978_ChIP-Seq_HELA_Human0.95259952
67CIITA_25753668_ChIP-Seq_RAJI_Human0.93865436
68RNF2_27304074_Chip-Seq_ESCs_Mouse0.92148279
69MAF_26560356_Chip-Seq_TH2_Human0.91750326
70KDM2B_26808549_Chip-Seq_DND41_Human0.91499622
71GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90662512
72TCF7_22412390_ChIP-Seq_EML_Mouse0.89937655
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.89070288
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88998941
75KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88431070
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86604154
77GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86029673
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85541052
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85375930
80GATA3_21878914_ChIP-Seq_MCF-7_Human0.85340188
81CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85212066
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84265293
83* TP53_22573176_ChIP-Seq_HFKS_Human0.84130913
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83432293
85EED_16625203_ChIP-ChIP_MESCs_Mouse0.83081554
86SMRT_27268052_Chip-Seq_Bcells_Human0.82536294
87SPI1_23127762_ChIP-Seq_K562_Human0.82394622
88GATA3_26560356_Chip-Seq_TH2_Human0.81891545
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81877610
90HTT_18923047_ChIP-ChIP_STHdh_Human0.80455098
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.78820808
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78003813
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77850336
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77387816
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.76326594
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.75189462
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74730119
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74730119
99ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74403848
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73861652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology4.25188008
2MP0005645_abnormal_hypothalamus_physiol2.57451683
3MP0000465_gastrointestinal_hemorrhage2.40404460
4MP0003879_abnormal_hair_cell2.23565053
5MP0003763_abnormal_thymus_physiology2.14198064
6MP0004859_abnormal_synaptic_plasticity2.10365651
7MP0003724_increased_susceptibility_to2.05180684
8MP0005671_abnormal_response_to2.04654638
9MP0004147_increased_porphyrin_level2.00142108
10MP0003880_abnormal_central_pattern1.99451739
11MP0003787_abnormal_imprinting1.88100147
12MP0002733_abnormal_thermal_nociception1.76714389
13MP0006276_abnormal_autonomic_nervous1.75746739
14MP0002822_catalepsy1.72716786
15MP0005646_abnormal_pituitary_gland1.71715160
16MP0008872_abnormal_physiological_respon1.71557745
17MP0008004_abnormal_stomach_pH1.65224390
18MP0003866_abnormal_defecation1.64458537
19MP0008569_lethality_at_weaning1.63060066
20MP0003656_abnormal_erythrocyte_physiolo1.60430695
21MP0001968_abnormal_touch/_nociception1.57660238
22MP0001800_abnormal_humoral_immune1.57526070
23MP0002653_abnormal_ependyma_morphology1.56886908
24MP0004130_abnormal_muscle_cell1.55295595
25MP0003635_abnormal_synaptic_transmissio1.54542799
26MP0001905_abnormal_dopamine_level1.53199990
27MP0005423_abnormal_somatic_nervous1.51997556
28MP0002272_abnormal_nervous_system1.50512203
29MP0004142_abnormal_muscle_tone1.50061868
30MP0001970_abnormal_pain_threshold1.48903088
31MP0002398_abnormal_bone_marrow1.47433616
32MP0002638_abnormal_pupillary_reflex1.43554734
33MP0009379_abnormal_foot_pigmentation1.43051862
34MP0002063_abnormal_learning/memory/cond1.41622235
35MP0009745_abnormal_behavioral_response1.38199353
36MP0002735_abnormal_chemical_nociception1.35816106
37MP0008877_abnormal_DNA_methylation1.35627849
38MP0005167_abnormal_blood-brain_barrier1.33763667
39MP0002736_abnormal_nociception_after1.32948290
40MP0003638_abnormal_response/metabolism_1.32357757
41MP0005000_abnormal_immune_tolerance1.30385145
42MP0001879_abnormal_lymphatic_vessel1.29566371
43MP0001986_abnormal_taste_sensitivity1.29412933
44MP0002572_abnormal_emotion/affect_behav1.28324320
45MP0005075_abnormal_melanosome_morpholog1.27748414
46MP0003011_delayed_dark_adaptation1.27725205
47MP0005083_abnormal_biliary_tract1.26111834
48MP0002064_seizures1.25848235
49MP0000230_abnormal_systemic_arterial1.25666251
50MP0002876_abnormal_thyroid_physiology1.24314703
51MP0001440_abnormal_grooming_behavior1.23709354
52MP0002909_abnormal_adrenal_gland1.23194287
53MP0001765_abnormal_ion_homeostasis1.22614598
54MP0002420_abnormal_adaptive_immunity1.21556113
55MP0004885_abnormal_endolymph1.19325319
56MP0001819_abnormal_immune_cell1.18459396
57MP0005084_abnormal_gallbladder_morpholo1.17909449
58MP0002723_abnormal_immune_serum1.16952605
59MP0001835_abnormal_antigen_presentation1.10751131
60MP0005310_abnormal_salivary_gland1.10366382
61MP0008961_abnormal_basal_metabolism1.10265495
62MP0002138_abnormal_hepatobiliary_system1.10051842
63MP0000689_abnormal_spleen_morphology1.09422588
64MP0000716_abnormal_immune_system1.09240877
65MP0003122_maternal_imprinting1.09060384
66MP0002067_abnormal_sensory_capabilities1.08384538
67MP0001851_eye_inflammation1.06597488
68MP0005397_hematopoietic_system_phenotyp1.05576988
69MP0001545_abnormal_hematopoietic_system1.05576988
70MP0002928_abnormal_bile_duct1.05549466
71MP0001188_hyperpigmentation1.05408599
72MP0000685_abnormal_immune_system1.05339153
73MP0002009_preneoplasia1.04830217
74MP0001663_abnormal_digestive_system1.03310021
75MP0000703_abnormal_thymus_morphology1.03127281
76MP0003436_decreased_susceptibility_to1.03082960
77MP0009046_muscle_twitch1.00551338
78MP0005551_abnormal_eye_electrophysiolog0.99337583
79MP0010155_abnormal_intestine_physiology0.98451484
80MP0004145_abnormal_muscle_electrophysio0.98176112
81MP0002722_abnormal_immune_system0.97936593
82MP0002429_abnormal_blood_cell0.96226186
83MP0004947_skin_inflammation0.95666641
84MP0002452_abnormal_antigen_presenting0.94413277
85MP0001664_abnormal_digestion0.93624372
86MP0004381_abnormal_hair_follicle0.89334163
87MP0000631_abnormal_neuroendocrine_gland0.88244719
88MP0005386_behavior/neurological_phenoty0.88025080
89MP0004924_abnormal_behavior0.88025080
90MP0004742_abnormal_vestibular_system0.87457366
91MP0002557_abnormal_social/conspecific_i0.87145403
92MP0005387_immune_system_phenotype0.86491465
93MP0001790_abnormal_immune_system0.86491465
94MP0002693_abnormal_pancreas_physiology0.84049478
95MP0001873_stomach_inflammation0.82855901
96MP0009333_abnormal_splenocyte_physiolog0.82751357
97MP0001485_abnormal_pinna_reflex0.82172486
98MP0008874_decreased_physiological_sensi0.81836677
99MP0008995_early_reproductive_senescence0.79779853
100MP0003121_genomic_imprinting0.77308489

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.43878570
2Petechiae (HP:0000967)4.84759659
3Menorrhagia (HP:0000132)4.24927315
4Epistaxis (HP:0000421)4.24308772
5Increased mean platelet volume (HP:0011877)4.13354519
6Abnormal platelet volume (HP:0011876)4.03064876
7Abnormality of the heme biosynthetic pathway (HP:0010472)4.00805964
8Purpura (HP:0000979)3.90425038
9Poikilocytosis (HP:0004447)3.64979655
10Abnormality of binocular vision (HP:0011514)3.47059210
11Diplopia (HP:0000651)3.47059210
12Gingival bleeding (HP:0000225)3.39664877
133-Methylglutaconic aciduria (HP:0003535)3.39246384
14Abnormal pupillary function (HP:0007686)3.19600545
15Febrile seizures (HP:0002373)3.16253127
16Papilledema (HP:0001085)3.06047494
17Spontaneous hematomas (HP:0007420)3.04471874
18Acanthocytosis (HP:0001927)3.04002683
19Hyperlipoproteinemia (HP:0010980)2.95976637
20Congenital stationary night blindness (HP:0007642)2.86162924
21Autoimmune hemolytic anemia (HP:0001890)2.83493787
22Limb dystonia (HP:0002451)2.82737641
23Visual hallucinations (HP:0002367)2.74685333
24Failure to thrive in infancy (HP:0001531)2.73844118
25Panhypogammaglobulinemia (HP:0003139)2.55953060
26Paralysis (HP:0003470)2.53525412
27Polyphagia (HP:0002591)2.51177876
28Abnormal platelet function (HP:0011869)2.48089090
29Impaired platelet aggregation (HP:0003540)2.48089090
30Abnormal rod and cone electroretinograms (HP:0008323)2.47745746
31Agitation (HP:0000713)2.37547879
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35057319
33Elevated erythrocyte sedimentation rate (HP:0003565)2.33867559
34Global brain atrophy (HP:0002283)2.31635184
35Stomatitis (HP:0010280)2.29415116
36Decreased circulating renin level (HP:0003351)2.24022336
37Abnormal eating behavior (HP:0100738)2.23679236
38Abnormal hemoglobin (HP:0011902)2.21117583
39Agammaglobulinemia (HP:0004432)2.19993099
40Chronic otitis media (HP:0000389)2.16156312
41Asplenia (HP:0001746)2.12745988
42Clumsiness (HP:0002312)2.11381006
43Microcytic anemia (HP:0001935)2.08389449
44Myokymia (HP:0002411)2.08129972
45Joint swelling (HP:0001386)2.03044875
46Polydipsia (HP:0001959)2.02303622
47Abnormal drinking behavior (HP:0030082)2.02303622
48Ventricular fibrillation (HP:0001663)2.00585301
49Abnormal ciliary motility (HP:0012262)1.98943769
50Encephalitis (HP:0002383)1.98708235
51Tinnitus (HP:0000360)1.98451956
52Atonic seizures (HP:0010819)1.98280640
53Abnormal respiratory epithelium morphology (HP:0012253)1.97613832
54Abnormal respiratory motile cilium morphology (HP:0005938)1.97613832
55Hyperthyroidism (HP:0000836)1.93796566
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93751029
57Aplasia/Hypoplasia of the spleen (HP:0010451)1.93345272
58Growth hormone excess (HP:0000845)1.93088278
59Decreased central vision (HP:0007663)1.92517637
60Abnormality of the axillary hair (HP:0100134)1.91616490
61Abnormality of secondary sexual hair (HP:0009888)1.91616490
62Chronic sinusitis (HP:0011109)1.91542483
63Abnormal hair whorl (HP:0010721)1.91208262
64Recurrent sinusitis (HP:0011108)1.89838608
65Focal motor seizures (HP:0011153)1.86803390
66Hypothermia (HP:0002045)1.85443589
67Absent/shortened dynein arms (HP:0200106)1.85221843
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.85221843
69Abnormal number of erythroid precursors (HP:0012131)1.81555977
70Abnormality of cells of the erythroid lineage (HP:0012130)1.80120325
71Epileptic encephalopathy (HP:0200134)1.80119072
72Inflammation of the large intestine (HP:0002037)1.78216661
73Increased IgM level (HP:0003496)1.77932747
74Gastrointestinal inflammation (HP:0004386)1.75111994
75Sleep apnea (HP:0010535)1.74426843
76Poor eye contact (HP:0000817)1.70560894
77Abnormality of T cells (HP:0002843)1.69162593
78Chronic obstructive pulmonary disease (HP:0006510)1.69146860
79Obstructive lung disease (HP:0006536)1.69146860
80Gastrointestinal stroma tumor (HP:0100723)1.66950630
81Thyroid-stimulating hormone excess (HP:0002925)1.66527542
82Vasculitis (HP:0002633)1.66260597
83Attenuation of retinal blood vessels (HP:0007843)1.64960491
84Abnormality of renin-angiotensin system (HP:0000847)1.64275567
85Oligomenorrhea (HP:0000876)1.63860656
86Eczematoid dermatitis (HP:0000976)1.62461209
87Abnormality of lateral ventricle (HP:0030047)1.60720152
88Abnormality of the prostate (HP:0008775)1.59712511
89Verrucae (HP:0200043)1.59409373
90Papilloma (HP:0012740)1.59409373
91Abnormality of B cell number (HP:0010975)1.59370035
92Hypercortisolism (HP:0001578)1.56139403
93Bony spicule pigmentary retinopathy (HP:0007737)1.55715896
94Increased density of long bones (HP:0006392)1.55298339
95Dyschromatopsia (HP:0007641)1.55129538
96Lymphopenia (HP:0001888)1.55103474
97Ankle clonus (HP:0011448)1.55094487
98Erythema (HP:0010783)1.54293703
99Increased intramyocellular lipid droplets (HP:0012240)1.53183541
100Renal cortical cysts (HP:0000803)1.53051739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.56219500
2TAOK33.49053574
3MAP4K13.00056790
4SIK22.69960979
5TEC2.63462647
6BTK2.19559048
7GRK62.18370182
8SYK2.15098544
9CAMKK22.05125733
10FES1.90186112
11ITK1.78070508
12PIM21.70658653
13MAPK131.70480167
14STK161.63756713
15GRK51.62587411
16CAMKK11.61902852
17TXK1.56480998
18TNK21.50048765
19ARAF1.46671417
20PRPF4B1.41955571
21EPHA31.40979799
22TAOK11.37078579
23TLK11.32854773
24GRK11.29613132
25EIF2AK11.27863892
26PRKCQ1.25549912
27PRKD21.23304812
28MAPK121.23289681
29SGK21.22383057
30HIPK21.20077351
31MAP3K111.16905914
32ADRBK21.16678638
33MARK11.16646219
34BMX1.13646546
35LYN1.11919293
36DAPK21.11210864
37PTK2B1.06219646
38PRKD31.04249374
39LMTK21.03094186
40CSF1R1.02774935
41MAP2K71.00324647
42MAP3K40.98335306
43BMPR20.94398025
44PINK10.93514175
45PRKCH0.92032782
46IKBKB0.91195021
47IKBKE0.89608133
48BLK0.89521782
49AKT30.89080204
50LCK0.88982976
51HCK0.88293261
52MAP2K40.87719939
53NTRK30.80704387
54SGK4940.78023481
55SGK2230.78023481
56MARK20.77782594
57PIM10.76510178
58SGK30.76341739
59DYRK1B0.75294261
60PASK0.73444829
61DYRK1A0.73275744
62MAP3K10.73150527
63MAP2K20.72712221
64PAK30.71954746
65TESK20.71323074
66MAPK150.71294360
67PRKD10.70694186
68KIT0.68282940
69ZAP700.67252404
70RAF10.67205594
71RET0.65979166
72NLK0.62732338
73DYRK30.62505446
74IRAK40.61181421
75PRKCG0.61039359
76MINK10.60186762
77CDK50.58397229
78NTRK20.57225870
79MAPKAPK30.55223183
80FYN0.55022443
81ADRBK10.54523224
82CSK0.54320932
83PDK10.53467273
84RPS6KA50.53440847
85PHKG20.49856930
86PHKG10.49856930
87JAK20.49795292
88SIK30.48999295
89UHMK10.48745198
90MST40.47999640
91MAP3K90.47119775
92PRKCD0.45476751
93JAK30.45381025
94MAP2K30.43140012
95DYRK20.42138373
96CDK190.41844541
97EPHA40.41358864
98MAPK70.40881364
99RPS6KA60.39311232
100MAPK30.38422074

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.69292486
2Platelet activation_Homo sapiens_hsa046112.51329842
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97840169
4Phototransduction_Homo sapiens_hsa047441.95607918
5T cell receptor signaling pathway_Homo sapiens_hsa046601.89919998
6Serotonergic synapse_Homo sapiens_hsa047261.88928728
7B cell receptor signaling pathway_Homo sapiens_hsa046621.86830469
8Nicotine addiction_Homo sapiens_hsa050331.85414109
9Morphine addiction_Homo sapiens_hsa050321.76935796
10Linoleic acid metabolism_Homo sapiens_hsa005911.70410229
11Amphetamine addiction_Homo sapiens_hsa050311.56633150
12GABAergic synapse_Homo sapiens_hsa047271.54258033
13Circadian entrainment_Homo sapiens_hsa047131.51841129
14Cholinergic synapse_Homo sapiens_hsa047251.50940303
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47080127
16Hematopoietic cell lineage_Homo sapiens_hsa046401.46482536
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.42271336
18Long-term depression_Homo sapiens_hsa047301.40431778
19Nitrogen metabolism_Homo sapiens_hsa009101.37509937
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36261965
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35740033
22Renin secretion_Homo sapiens_hsa049241.34207767
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.27178975
24Cocaine addiction_Homo sapiens_hsa050301.25427870
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22511889
26Dopaminergic synapse_Homo sapiens_hsa047281.18001693
27Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17283438
28Arachidonic acid metabolism_Homo sapiens_hsa005901.16298494
29Chemokine signaling pathway_Homo sapiens_hsa040621.14079341
30Glutamatergic synapse_Homo sapiens_hsa047241.12358782
31Olfactory transduction_Homo sapiens_hsa047401.11601207
32Collecting duct acid secretion_Homo sapiens_hsa049661.08886784
33Long-term potentiation_Homo sapiens_hsa047201.05905385
34Oxytocin signaling pathway_Homo sapiens_hsa049211.05520873
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05343379
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.04708476
37Alcoholism_Homo sapiens_hsa050341.04072965
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03422958
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02562742
40Regulation of autophagy_Homo sapiens_hsa041401.02208951
41Pancreatic secretion_Homo sapiens_hsa049721.01592996
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01556851
43Synaptic vesicle cycle_Homo sapiens_hsa047211.00845432
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99843003
45Ether lipid metabolism_Homo sapiens_hsa005650.98082425
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97455186
47Insulin secretion_Homo sapiens_hsa049110.97087191
48Type I diabetes mellitus_Homo sapiens_hsa049400.96641835
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94566314
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93887883
51Autoimmune thyroid disease_Homo sapiens_hsa053200.92943446
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92280594
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91430452
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.87930483
55Type II diabetes mellitus_Homo sapiens_hsa049300.86993569
56Glycerolipid metabolism_Homo sapiens_hsa005610.84341501
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84208407
58Allograft rejection_Homo sapiens_hsa053300.83098312
59VEGF signaling pathway_Homo sapiens_hsa043700.82887085
60Choline metabolism in cancer_Homo sapiens_hsa052310.80880398
61MAPK signaling pathway_Homo sapiens_hsa040100.79274652
62Graft-versus-host disease_Homo sapiens_hsa053320.78573180
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76378666
64Ras signaling pathway_Homo sapiens_hsa040140.75969730
65Gap junction_Homo sapiens_hsa045400.75484296
66Non-small cell lung cancer_Homo sapiens_hsa052230.74453306
67Dorso-ventral axis formation_Homo sapiens_hsa043200.74120542
68cAMP signaling pathway_Homo sapiens_hsa040240.73581463
69Calcium signaling pathway_Homo sapiens_hsa040200.73283729
70Cardiac muscle contraction_Homo sapiens_hsa042600.71689946
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.70968568
72Endometrial cancer_Homo sapiens_hsa052130.70880876
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70147324
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66293081
75Taste transduction_Homo sapiens_hsa047420.65225855
76Endocytosis_Homo sapiens_hsa041440.64494324
77Butanoate metabolism_Homo sapiens_hsa006500.63956542
78Gastric acid secretion_Homo sapiens_hsa049710.62721471
79GnRH signaling pathway_Homo sapiens_hsa049120.62704213
80Circadian rhythm_Homo sapiens_hsa047100.61500637
81FoxO signaling pathway_Homo sapiens_hsa040680.60664510
82Renal cell carcinoma_Homo sapiens_hsa052110.60306666
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60291670
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57252743
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.56289645
86Acute myeloid leukemia_Homo sapiens_hsa052210.56267809
87Sulfur relay system_Homo sapiens_hsa041220.56174587
88Salivary secretion_Homo sapiens_hsa049700.55721431
89Asthma_Homo sapiens_hsa053100.53226035
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52967519
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52545248
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51891327
93Notch signaling pathway_Homo sapiens_hsa043300.50550211
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.49442717
95Pancreatic cancer_Homo sapiens_hsa052120.49406107
96Parkinsons disease_Homo sapiens_hsa050120.48259577
97Colorectal cancer_Homo sapiens_hsa052100.46445766
98Oxidative phosphorylation_Homo sapiens_hsa001900.42905206
99Prolactin signaling pathway_Homo sapiens_hsa049170.41987653
100Alzheimers disease_Homo sapiens_hsa050100.41215261

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