SRSF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)5.30041473
2DNA deamination (GO:0045006)5.06976629
3proline biosynthetic process (GO:0006561)4.83648400
4deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.65345204
5replication fork processing (GO:0031297)4.56088580
6establishment of integrated proviral latency (GO:0075713)4.36064497
7telomere maintenance via semi-conservative replication (GO:0032201)4.33650157
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.33061551
9nucleobase-containing small molecule interconversion (GO:0015949)4.25693751
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.16056617
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.16056617
12regulation of posttranscriptional gene silencing (GO:0060147)4.13270912
13regulation of gene silencing by miRNA (GO:0060964)4.13270912
14regulation of gene silencing by RNA (GO:0060966)4.13270912
15embryonic process involved in female pregnancy (GO:0060136)4.12571165
16DNA strand elongation involved in DNA replication (GO:0006271)4.07207449
17mitotic chromosome condensation (GO:0007076)3.98436426
18viral transcription (GO:0019083)3.96742560
19DNA double-strand break processing (GO:0000729)3.95970857
20transcription from mitochondrial promoter (GO:0006390)3.94896740
21establishment of apical/basal cell polarity (GO:0035089)3.89182524
22viral mRNA export from host cell nucleus (GO:0046784)3.83935426
23ribosomal small subunit assembly (GO:0000028)3.83631391
24DNA strand elongation (GO:0022616)3.81123396
25translational termination (GO:0006415)3.79909175
26ribosomal small subunit biogenesis (GO:0042274)3.79767224
27pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.78900813
28protein maturation by protein folding (GO:0022417)3.75653481
29dosage compensation (GO:0007549)3.73766269
30pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.71518576
31telomere maintenance via recombination (GO:0000722)3.69898454
32DNA unwinding involved in DNA replication (GO:0006268)3.65732210
33establishment of viral latency (GO:0019043)3.62659056
34peptidyl-arginine omega-N-methylation (GO:0035247)3.60876538
35UTP biosynthetic process (GO:0006228)3.58880409
36nucleosome disassembly (GO:0006337)3.58859941
37protein-DNA complex disassembly (GO:0032986)3.58859941
38maturation of SSU-rRNA (GO:0030490)3.56110643
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.53552405
40* negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53540022
41translational initiation (GO:0006413)3.53482215
42pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.51935073
43DNA replication checkpoint (GO:0000076)3.51027249
44guanosine-containing compound biosynthetic process (GO:1901070)3.49305426
45nucleotide-excision repair, DNA gap filling (GO:0006297)3.48976594
46pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.46029671
47Golgi transport vesicle coating (GO:0048200)3.44024019
48COPI coating of Golgi vesicle (GO:0048205)3.44024019
49regulation of mitochondrial translation (GO:0070129)3.42561421
50mitotic recombination (GO:0006312)3.41590834
51* termination of RNA polymerase II transcription (GO:0006369)3.41016025
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.39627055
53* negative regulation of mRNA metabolic process (GO:1903312)3.39136532
54spliceosomal tri-snRNP complex assembly (GO:0000244)3.39080024
55positive regulation of protein homooligomerization (GO:0032464)3.35672316
56DNA replication initiation (GO:0006270)3.34327837
57translational elongation (GO:0006414)3.33219876
58nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32265772
59RNA stabilization (GO:0043489)3.31962828
60mRNA stabilization (GO:0048255)3.31962828
61establishment of monopolar cell polarity (GO:0061162)3.28391436
62establishment or maintenance of monopolar cell polarity (GO:0061339)3.28391436
63ribonucleoprotein complex biogenesis (GO:0022613)3.28246466
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27430624
65protein retention in ER lumen (GO:0006621)3.24893447
663-UTR-mediated mRNA stabilization (GO:0070935)3.23982522
67UTP metabolic process (GO:0046051)3.23955756
68heterochromatin organization (GO:0070828)3.23900050
69ribosome biogenesis (GO:0042254)3.23873407
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.22165634
71regulation of double-strand break repair (GO:2000779)3.21472594
72protein targeting to ER (GO:0045047)3.21439402
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.21370617
74pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.20972071
75folic acid-containing compound biosynthetic process (GO:0009396)3.20386095
76mitotic sister chromatid segregation (GO:0000070)3.20007541
77ribosome assembly (GO:0042255)3.19813581
78cotranslational protein targeting to membrane (GO:0006613)3.19666546
79post-embryonic morphogenesis (GO:0009886)3.19485478
80GTP biosynthetic process (GO:0006183)3.19408486
81kinetochore assembly (GO:0051382)3.19062822
82deoxyribose phosphate biosynthetic process (GO:0046385)3.18510207
832-deoxyribonucleotide biosynthetic process (GO:0009265)3.18510207
84ribosomal large subunit biogenesis (GO:0042273)3.18387160
85CTP metabolic process (GO:0046036)3.17411211
86CTP biosynthetic process (GO:0006241)3.17411211
87base-excision repair (GO:0006284)3.17137934
88DNA strand renaturation (GO:0000733)3.16273242
89* negative regulation of mRNA processing (GO:0050686)3.14805645
90pyrimidine nucleotide catabolic process (GO:0006244)3.13781375
91pentose-phosphate shunt (GO:0006098)3.13564808
92poly(A)+ mRNA export from nucleus (GO:0016973)3.12509566
93macromolecular complex disassembly (GO:0032984)3.11832732
94pseudouridine synthesis (GO:0001522)3.11411378
95protein localization to kinetochore (GO:0034501)3.11105098
96* negative regulation of RNA splicing (GO:0033119)3.10484930
97rRNA processing (GO:0006364)3.08745711
98proline metabolic process (GO:0006560)3.08671312
99nuclear envelope reassembly (GO:0031468)3.07809796
100mitotic nuclear envelope reassembly (GO:0007084)3.07809796
101viral life cycle (GO:0019058)3.07372111
102kinetochore organization (GO:0051383)3.06753497
103DNA replication-dependent nucleosome organization (GO:0034723)3.06184029
104DNA replication-dependent nucleosome assembly (GO:0006335)3.06184029
105maturation of 5.8S rRNA (GO:0000460)3.06087708
106telomere maintenance via telomere lengthening (GO:0010833)3.03967826
107mitotic G1 DNA damage checkpoint (GO:0031571)3.02845163
108establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02240340
109peptidyl-arginine methylation (GO:0018216)3.01853845
110peptidyl-arginine N-methylation (GO:0035246)3.01853845
111protein localization to endoplasmic reticulum (GO:0070972)3.00674977
112meiotic chromosome segregation (GO:0045132)3.00014042
113DNA topological change (GO:0006265)3.00005457
114positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.99471413
115negative regulation of cell cycle arrest (GO:0071157)2.99388986
116cellular protein complex disassembly (GO:0043624)2.95982862
117rRNA metabolic process (GO:0016072)2.94782886
118protein complex localization (GO:0031503)2.94506128
119deoxyribonucleotide biosynthetic process (GO:0009263)2.92393416
120regulation of translational termination (GO:0006449)2.91264014
121regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91040736
122rRNA transcription (GO:0009303)2.90745324
123mitochondrial DNA metabolic process (GO:0032042)2.90612829
124mRNA cleavage (GO:0006379)2.86582016
125G1 DNA damage checkpoint (GO:0044783)2.85876432
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.83268786
127chromatin assembly (GO:0031497)2.82895510
128histone H4-K12 acetylation (GO:0043983)2.82279799
129positive regulation of chromosome segregation (GO:0051984)2.82184229
130pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81743404
131regulation of translational fidelity (GO:0006450)2.80060521
132DNA integration (GO:0015074)2.80021475
133regulation of mRNA stability (GO:0043488)2.79706646
134mitotic nuclear envelope disassembly (GO:0007077)2.79656982
135nuclear-transcribed mRNA catabolic process (GO:0000956)2.78948279
136histone arginine methylation (GO:0034969)2.78495657
137DNA synthesis involved in DNA repair (GO:0000731)2.77976805
138positive regulation of developmental pigmentation (GO:0048087)2.77813156
139NADPH regeneration (GO:0006740)2.77140657
140* RNA splicing, via transesterification reactions (GO:0000375)2.76739007
141trophectodermal cell differentiation (GO:0001829)2.76641654
142spliceosomal snRNP assembly (GO:0000387)2.76530060
143translation (GO:0006412)2.76394375
144protein complex disassembly (GO:0043241)2.76099245
145regulation of stem cell maintenance (GO:2000036)2.75990375
146double-strand break repair via nonhomologous end joining (GO:0006303)2.75842173
147non-recombinational repair (GO:0000726)2.75842173
148protein localization to chromosome, centromeric region (GO:0071459)2.75196344
149* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74117608
150* mRNA splicing, via spliceosome (GO:0000398)2.74117608
151regulation of integrin activation (GO:0033623)2.73950138
152DNA duplex unwinding (GO:0032508)2.72366107
153regulation of protein heterodimerization activity (GO:0043497)2.72012444
154sister chromatid segregation (GO:0000819)2.71214833
155pyrimidine nucleotide biosynthetic process (GO:0006221)2.71174409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57227100
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.92338270
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.74663375
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.74663375
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.74663375
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37754526
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06145626
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.01708496
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96755180
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64101844
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57376672
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55257621
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31459410
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.25956557
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.18708243
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12724495
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09563442
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.08136373
19ZNF263_19887448_ChIP-Seq_K562_Human2.03054187
20XRN2_22483619_ChIP-Seq_HELA_Human2.02747802
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00767449
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99646379
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95195006
24VDR_21846776_ChIP-Seq_THP-1_Human1.91677168
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86021842
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85254288
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79421969
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78641693
29MYC_22102868_ChIP-Seq_BL_Human1.77910181
30DCP1A_22483619_ChIP-Seq_HELA_Human1.76519360
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74492302
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.72705663
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72315262
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71822233
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71683826
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70724677
37TTF2_22483619_ChIP-Seq_HELA_Human1.70422959
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70329320
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67501637
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.66719602
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66531823
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65324352
43VDR_23849224_ChIP-Seq_CD4+_Human1.62907352
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62013544
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.60251278
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.59811308
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59255663
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57515586
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.55949832
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.55485545
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55035801
52GABP_19822575_ChIP-Seq_HepG2_Human1.54036449
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53818055
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52470873
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.50855253
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49780530
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47416617
58LXR_22292898_ChIP-Seq_THP-1_Human1.46406633
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45074559
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44741618
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43949568
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43096737
63RACK7_27058665_Chip-Seq_MCF-7_Human1.42783798
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41691585
65TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41235651
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38996598
67ELK1_19687146_ChIP-ChIP_HELA_Human1.33734397
68KDM5A_27292631_Chip-Seq_BREAST_Human1.33598594
69FOXP3_21729870_ChIP-Seq_TREG_Human1.33596061
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32562637
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31614510
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30873331
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29288217
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.27830771
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26020352
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22150570
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19266994
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18764252
79TFEB_21752829_ChIP-Seq_HELA_Human1.18461197
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17105497
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17067582
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16294318
83TCF7_22412390_ChIP-Seq_EML_Mouse1.15809357
84KDM2B_26808549_Chip-Seq_DND41_Human1.15762561
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14836462
86POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13031801
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12770327
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11789266
89SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10790716
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10388571
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.10158672
92OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10136163
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10101340
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09652473
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08785097
96CHD1_26751641_Chip-Seq_LNCaP_Human1.08297625
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07946379
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07933513
99VDR_24763502_ChIP-Seq_THP-1_Human1.07870111
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07702046
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06802807
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06033944
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05794366
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05758414
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05020377
106NCOR1_26117541_ChIP-Seq_K562_Human1.03879210
107SPI1_23547873_ChIP-Seq_NB4_Human1.03248268
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03197181
109TP63_17297297_ChIP-ChIP_HaCaT_Human1.03108575
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02969363
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02886177
112KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02393897
113CLOCK_20551151_ChIP-Seq_293T_Human1.01616356
114P68_20966046_ChIP-Seq_HELA_Human1.01361681
115AR_21909140_ChIP-Seq_LNCAP_Human1.00562599
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99941555
117MAF_26560356_Chip-Seq_TH1_Human0.99424742
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99381237
119FOXP1_21924763_ChIP-Seq_HESCs_Human0.98810438
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98637961
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98378625
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98371380
123MAF_26560356_Chip-Seq_TH2_Human0.98298338
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98179717
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97370299
126CIITA_25753668_ChIP-Seq_RAJI_Human0.96977108
127UTX_26944678_Chip-Seq_JUKART_Human0.96913333
128ATF3_27146783_Chip-Seq_COLON_Human0.96891023
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96685504
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96611052
131POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95825619
132HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95256462
133NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93698206
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93553723
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93194183
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91224006
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90585659
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89943999

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.45395900
2MP0010352_gastrointestinal_tract_polyps3.34643759
3MP0004957_abnormal_blastocyst_morpholog3.32100635
4MP0010094_abnormal_chromosome_stability2.93749709
5MP0003693_abnormal_embryo_hatching2.92307960
6MP0010030_abnormal_orbit_morphology2.59053300
7MP0003077_abnormal_cell_cycle2.50626098
8MP0005171_absent_coat_pigmentation2.48171182
9MP0002877_abnormal_melanocyte_morpholog2.46448945
10MP0009379_abnormal_foot_pigmentation2.41847229
11MP0009278_abnormal_bone_marrow2.38503044
12MP0004185_abnormal_adipocyte_glucose2.35799358
13MP0003111_abnormal_nucleus_morphology2.31256486
14MP0008932_abnormal_embryonic_tissue2.30218633
15MP0006292_abnormal_olfactory_placode2.25649227
16MP0003890_abnormal_embryonic-extraembry2.16454296
17MP0003315_abnormal_perineum_morphology2.16427318
18MP0003123_paternal_imprinting2.16243912
19MP0008058_abnormal_DNA_repair2.12894468
20MP0000537_abnormal_urethra_morphology2.08397528
21MP0008877_abnormal_DNA_methylation2.00152978
22MP0005451_abnormal_body_composition1.98636016
23MP0004858_abnormal_nervous_system1.97302296
24MP0000490_abnormal_crypts_of1.88893229
25MP0005501_abnormal_skin_physiology1.86264827
26MP0000566_synostosis1.85921186
27MP0002796_impaired_skin_barrier1.78138952
28MP0000350_abnormal_cell_proliferation1.77714301
29MP0003786_premature_aging1.76239599
30MP0005076_abnormal_cell_differentiation1.69277956
31MP0004197_abnormal_fetal_growth/weight/1.67473121
32MP0010234_abnormal_vibrissa_follicle1.64595006
33MP0009672_abnormal_birth_weight1.63178852
34MP0001293_anophthalmia1.58058188
35MP0005174_abnormal_tail_pigmentation1.55691049
36MP0002085_abnormal_embryonic_tissue1.54914987
37MP0008007_abnormal_cellular_replicative1.54797914
38MP0002234_abnormal_pharynx_morphology1.54021553
39MP0004133_heterotaxia1.50661703
40MP0001697_abnormal_embryo_size1.48673528
41MP0002086_abnormal_extraembryonic_tissu1.48310296
42MP0001849_ear_inflammation1.48266441
43MP0003119_abnormal_digestive_system1.47387535
44MP0002084_abnormal_developmental_patter1.46286654
45MP0003567_abnormal_fetal_cardiomyocyte1.45783731
46MP0001545_abnormal_hematopoietic_system1.45126103
47MP0005397_hematopoietic_system_phenotyp1.45126103
48MP0001730_embryonic_growth_arrest1.43924627
49MP0008995_early_reproductive_senescence1.42888598
50MP0001672_abnormal_embryogenesis/_devel1.41350835
51MP0005380_embryogenesis_phenotype1.41350835
52MP0002009_preneoplasia1.39093790
53MP0002396_abnormal_hematopoietic_system1.37060672
54MP0005075_abnormal_melanosome_morpholog1.36563904
55MP0001881_abnormal_mammary_gland1.35933410
56MP0001346_abnormal_lacrimal_gland1.33909852
57MP0002249_abnormal_larynx_morphology1.29897437
58MP0002282_abnormal_trachea_morphology1.29251675
59MP0002019_abnormal_tumor_incidence1.29136222
60MP0002653_abnormal_ependyma_morphology1.26475958
61MP0000313_abnormal_cell_death1.26258452
62MP0009333_abnormal_splenocyte_physiolog1.25462348
63MP0010307_abnormal_tumor_latency1.18882344
64MP0002080_prenatal_lethality1.16755791
65MP0003984_embryonic_growth_retardation1.16453795
66MP0003121_genomic_imprinting1.15056106
67MP0002088_abnormal_embryonic_growth/wei1.13786617
68MP0008260_abnormal_autophagy1.12010692
69MP0005058_abnormal_lysosome_morphology1.10955108
70MP0002163_abnormal_gland_morphology1.10027346
71MP0000049_abnormal_middle_ear1.08485315
72MP0002277_abnormal_respiratory_mucosa1.06442568
73MP0003448_altered_tumor_morphology1.04636397
74MP0000627_abnormal_mammary_gland1.04312526
75MP0003453_abnormal_keratinocyte_physiol1.04174471
76MP0005666_abnormal_adipose_tissue1.03639702
77MP0006072_abnormal_retinal_apoptosis1.03541184
78MP0003136_yellow_coat_color1.03345191
79MP0003566_abnormal_cell_adhesion1.02132023
80MP0002111_abnormal_tail_morphology0.99426121
81MP0005621_abnormal_cell_physiology0.98112050
82MP0003806_abnormal_nucleotide_metabolis0.96172678
83MP0002932_abnormal_joint_morphology0.95949385
84MP0002751_abnormal_autonomic_nervous0.94760717
85MP0000678_abnormal_parathyroid_gland0.94562877
86MP0002398_abnormal_bone_marrow0.94404142
87MP0005384_cellular_phenotype0.94356372
88MP0000015_abnormal_ear_pigmentation0.94301807
89MP0000685_abnormal_immune_system0.93745499
90MP0009053_abnormal_anal_canal0.93355294
91MP0000681_abnormal_thyroid_gland0.92661027
92MP0000689_abnormal_spleen_morphology0.92364441
93MP0005623_abnormal_meninges_morphology0.92316736
94MP0002697_abnormal_eye_size0.91578406
95MP0003755_abnormal_palate_morphology0.91040353
96MP0001727_abnormal_embryo_implantation0.89862137
97MP0003705_abnormal_hypodermis_morpholog0.89796912
98MP0003122_maternal_imprinting0.89647788
99MP0003938_abnormal_ear_development0.89306488
100MP0005375_adipose_tissue_phenotype0.89295468
101MP0004808_abnormal_hematopoietic_stem0.88932687
102MP0000477_abnormal_intestine_morphology0.88540343
103MP0000358_abnormal_cell_content/0.87901440
104MP0005220_abnormal_exocrine_pancreas0.87188582
105MP0002405_respiratory_system_inflammati0.86907542
106MP0000703_abnormal_thymus_morphology0.86758668
107MP0000858_altered_metastatic_potential0.86324207
108MP0000762_abnormal_tongue_morphology0.85638963
109MP0001145_abnormal_male_reproductive0.85617050
110MP0002722_abnormal_immune_system0.84544159
111MP0004264_abnormal_extraembryonic_tissu0.83704524
112MP0002089_abnormal_postnatal_growth/wei0.83688140
113MP0001186_pigmentation_phenotype0.83254025
114MP0006082_CNS_inflammation0.82455618
115MP0002132_abnormal_respiratory_system0.81592815
116MP0002098_abnormal_vibrissa_morphology0.81354345
117MP0002075_abnormal_coat/hair_pigmentati0.80850482
118MP0001873_stomach_inflammation0.80796234
119MP0003283_abnormal_digestive_organ0.80788301
120MP0002210_abnormal_sex_determination0.80643284
121MP0003942_abnormal_urinary_system0.80562852
122MP0003385_abnormal_body_wall0.80491543
123MP0002092_abnormal_eye_morphology0.80292568
124MP0000432_abnormal_head_morphology0.78938522
125MP0002114_abnormal_axial_skeleton0.78683543
126MP0000003_abnormal_adipose_tissue0.78612643
127MP0003186_abnormal_redox_activity0.78168897
128MP0000613_abnormal_salivary_gland0.77740069
129MP0000465_gastrointestinal_hemorrhage0.77462932
130MP0000371_diluted_coat_color0.77303886
131MP0009931_abnormal_skin_appearance0.76437072
132MP0003763_abnormal_thymus_physiology0.75794074
133MP0004782_abnormal_surfactant_physiolog0.75682713
134MP0003828_pulmonary_edema0.74955816
135MP0003436_decreased_susceptibility_to0.74930120
136MP0003935_abnormal_craniofacial_develop0.74597537
137MP0004233_abnormal_muscle_weight0.73340501
138MP0002938_white_spotting0.73106534
139MP0001216_abnormal_epidermal_layer0.72588787
140MP0002429_abnormal_blood_cell0.71478679
141MP0000470_abnormal_stomach_morphology0.71299694
142MP0001835_abnormal_antigen_presentation0.71289093
143MP0002116_abnormal_craniofacial_bone0.70635827
144MP0009697_abnormal_copulation0.69576613
145MP0000428_abnormal_craniofacial_morphol0.68755562
146MP0003937_abnormal_limbs/digits/tail_de0.68600934
147MP0006035_abnormal_mitochondrial_morpho0.68534090

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.30825470
2Rectovaginal fistula (HP:0000143)4.14494372
3Rectal fistula (HP:0100590)4.14494372
4Microvesicular hepatic steatosis (HP:0001414)3.70149566
5Facial hemangioma (HP:0000329)3.60044204
6Concave nail (HP:0001598)3.58348137
7Intestinal fistula (HP:0100819)3.55749867
8Progressive muscle weakness (HP:0003323)3.43199590
9Multiple enchondromatosis (HP:0005701)3.42081000
10Agnosia (HP:0010524)3.41863233
11Vaginal fistula (HP:0004320)3.36910326
12Hyperacusis (HP:0010780)3.36381414
13Broad distal phalanx of finger (HP:0009836)3.30146364
14Abnormality of cells of the erythroid lineage (HP:0012130)3.28699443
15Pustule (HP:0200039)3.23787582
16Selective tooth agenesis (HP:0001592)3.22592606
17Aplasia/hypoplasia of the humerus (HP:0006507)3.15461393
18Basal cell carcinoma (HP:0002671)3.02376582
19Absent radius (HP:0003974)2.98903418
20Orthostatic hypotension (HP:0001278)2.98350328
21Abnormal number of erythroid precursors (HP:0012131)2.98089420
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.97970955
23Ragged-red muscle fibers (HP:0003200)2.93953499
24Achilles tendon contracture (HP:0001771)2.91834598
25Annular pancreas (HP:0001734)2.91513257
26Intestinal atresia (HP:0011100)2.90569945
27Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.90126656
28Vertebral hypoplasia (HP:0008417)2.90126656
29Short humerus (HP:0005792)2.89914588
30Increased IgM level (HP:0003496)2.87604031
31Thrombocytosis (HP:0001894)2.85068670
32Missing ribs (HP:0000921)2.82645439
33Absent forearm bone (HP:0003953)2.80393741
34Aplasia involving forearm bones (HP:0009822)2.80393741
35Tongue fasciculations (HP:0001308)2.76701660
36Patellar aplasia (HP:0006443)2.71563861
37Absent thumb (HP:0009777)2.71450987
38Pseudobulbar signs (HP:0002200)2.66841913
39Rhabdomyosarcoma (HP:0002859)2.64330497
40Microretrognathia (HP:0000308)2.62211944
41Abnormal number of incisors (HP:0011064)2.62115154
42Ependymoma (HP:0002888)2.60259976
43Aplasia/Hypoplasia of the patella (HP:0006498)2.59862334
44Ulnar bowing (HP:0003031)2.58712991
45Breast hypoplasia (HP:0003187)2.57994003
46Insomnia (HP:0100785)2.55495797
47Abnormality of the labia minora (HP:0012880)2.53488560
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50776012
49Reticulocytopenia (HP:0001896)2.47097348
50Abnormality of the Achilles tendon (HP:0005109)2.44314581
5111 pairs of ribs (HP:0000878)2.41484955
52Colon cancer (HP:0003003)2.41173265
53Deep palmar crease (HP:0006191)2.37549057
54Squamous cell carcinoma (HP:0002860)2.34239149
55Abnormality of the phalanges of the hallux (HP:0010057)2.32427356
56Long palpebral fissure (HP:0000637)2.32086792
57Muscle fibrillation (HP:0010546)2.28246804
58Medulloblastoma (HP:0002885)2.27461511
59High anterior hairline (HP:0009890)2.25351463
60Abnormality of the ileum (HP:0001549)2.24619348
61Shawl scrotum (HP:0000049)2.23123145
62Hypochromic microcytic anemia (HP:0004840)2.21750031
63Poikiloderma (HP:0001029)2.21681305
64Septate vagina (HP:0001153)2.21127400
65Abnormality of the astrocytes (HP:0100707)2.20824223
66Astrocytoma (HP:0009592)2.20824223
67Testicular atrophy (HP:0000029)2.20378065
68Spinal muscular atrophy (HP:0007269)2.19954534
69Supernumerary spleens (HP:0009799)2.18765141
70Abnormal hemoglobin (HP:0011902)2.15901920
71Coronal craniosynostosis (HP:0004440)2.15412159
72Dysautonomia (HP:0002459)2.15369786
73Vertebral fusion (HP:0002948)2.14671112
74Premature graying of hair (HP:0002216)2.14618841
75Nephroblastoma (Wilms tumor) (HP:0002667)2.14449313
76Vertebral compression fractures (HP:0002953)2.14223156
77Overlapping toe (HP:0001845)2.13334353
78Gastrointestinal atresia (HP:0002589)2.12579826
79Deviation of the thumb (HP:0009603)2.12162284
80Proximal placement of thumb (HP:0009623)2.11400056
81Asymmetry of the thorax (HP:0001555)2.10558396
82Overriding aorta (HP:0002623)2.09574468
83Unilateral renal agenesis (HP:0000122)2.09094099
84Neoplasm of striated muscle (HP:0009728)2.08526874
85Hypertensive crisis (HP:0100735)2.08102892
86Abnormality of reticulocytes (HP:0004312)2.07930770
87Abnormality of the fetal cardiovascular system (HP:0010948)2.07375439
88Abnormal umbilical cord blood vessels (HP:0011403)2.07375439
89Single umbilical artery (HP:0001195)2.07375439
90Abnormality of the umbilical cord (HP:0010881)2.07020691
91Acute lymphatic leukemia (HP:0006721)2.06309220
92Abnormality of the distal phalanx of the thumb (HP:0009617)2.05267392
93Patellar dislocation (HP:0002999)2.05231107
94Cellulitis (HP:0100658)2.03317794
95Embryonal renal neoplasm (HP:0011794)2.02887582
96Hemivertebrae (HP:0002937)2.01169623
97Partial duplication of thumb phalanx (HP:0009944)1.97039793
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.95700022
99Trismus (HP:0000211)1.94840224
100Asplenia (HP:0001746)1.94390386
101Fused cervical vertebrae (HP:0002949)1.94092229
102Decreased activity of mitochondrial respiratory chain (HP:0008972)1.93857895
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.93857895
104Aplastic anemia (HP:0001915)1.92613993
105Broad alveolar ridges (HP:0000187)1.91407768
106Hypochromic anemia (HP:0001931)1.90924657
107Abnormality of the anterior horn cell (HP:0006802)1.90736408
108Degeneration of anterior horn cells (HP:0002398)1.90736408
109Abnormal lung lobation (HP:0002101)1.90533110
110Rough bone trabeculation (HP:0100670)1.89641451
111Increased nuchal translucency (HP:0010880)1.88458166
112Abnormality of the thoracic spine (HP:0100711)1.88205963
113Esophageal atresia (HP:0002032)1.88190350
114Pallor (HP:0000980)1.88185702
115Hyperthyroidism (HP:0000836)1.88060280
116Elfin facies (HP:0004428)1.87813700
117Short 5th finger (HP:0009237)1.86986033
118Thoracic kyphosis (HP:0002942)1.86478911
119Hypoplasia of the radius (HP:0002984)1.86213538
120Abnormality of the distal phalanges of the toes (HP:0010182)1.86076325
121Hyperparathyroidism (HP:0000843)1.85707901
122Dysphonia (HP:0001618)1.85198513
123Hypoparathyroidism (HP:0000829)1.84737959
124Abnormality of the aortic arch (HP:0012303)1.81459761
125Renal duplication (HP:0000075)1.81365666
126Birth length less than 3rd percentile (HP:0003561)1.80972108
127Short middle phalanx of the 5th finger (HP:0004220)1.80904554
128Truncus arteriosus (HP:0001660)1.80024299
129Meckel diverticulum (HP:0002245)1.79740125
130Fasciculations (HP:0002380)1.79612049
131Glossoptosis (HP:0000162)1.79004914
132Partial duplication of the phalanx of hand (HP:0009999)1.78662026
133Duplication of thumb phalanx (HP:0009942)1.77838043
134Macrocytic anemia (HP:0001972)1.76741085
135Myelodysplasia (HP:0002863)1.76649780
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.75817308
137Spinal cord lesions (HP:0100561)1.74384576
138Syringomyelia (HP:0003396)1.74384576
139Aplasia/Hypoplasia of the thymus (HP:0010515)1.73345011
140Growth hormone excess (HP:0000845)1.72860623
141Neoplasm of the oral cavity (HP:0100649)1.72042379
142Ankyloglossia (HP:0010296)1.71987798
143Short thumb (HP:0009778)1.70112369
144Carpal bone hypoplasia (HP:0001498)1.69778528
145Hypotelorism (HP:0000601)1.69563276
146Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69551284
147Flat acetabular roof (HP:0003180)1.69363049
148Facial cleft (HP:0002006)1.69261858
149Abnormality of male internal genitalia (HP:0000022)1.68758622
150Flattened epiphyses (HP:0003071)1.68662813
151Tracheoesophageal fistula (HP:0002575)1.67998158
152Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.67299665
153Back pain (HP:0003418)1.66912641
154Glioma (HP:0009733)1.65865793
155Progressive external ophthalmoplegia (HP:0000590)1.65134016
156Spastic diplegia (HP:0001264)1.64912486
157Pointed chin (HP:0000307)1.64812327
158Hypotrichosis (HP:0001006)1.63120713
159IgA deficiency (HP:0002720)1.62233765
160Neoplasm of the pancreas (HP:0002894)1.62069393
161Chromsome breakage (HP:0040012)1.61873550
162Preaxial foot polydactyly (HP:0001841)1.61744381
163Supernumerary ribs (HP:0005815)1.61317278
164Abnormality of T cell physiology (HP:0011840)1.61257537
165Breech presentation (HP:0001623)1.61114399
166Flared metaphyses (HP:0003015)1.61008001
167Reduced antithrombin III activity (HP:0001976)1.60996670
168Cleft eyelid (HP:0000625)1.60936493
169Atresia of the external auditory canal (HP:0000413)1.60652067
170Pancytopenia (HP:0001876)1.59813323
171Broad thumb (HP:0011304)1.59301831
172Supernumerary bones of the axial skeleton (HP:0009144)1.59010590
173Preauricular skin tag (HP:0000384)1.57591864
174Pili torti (HP:0003777)1.56974150
175Abnormality of glycolysis (HP:0004366)1.55598041
176Seborrheic dermatitis (HP:0001051)1.54852843
177Hypercalcemia (HP:0003072)1.53280232
178Secondary amenorrhea (HP:0000869)1.53169122
179Abnormality of the calcaneus (HP:0008364)1.50531635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.10129909
2TRIB33.45398064
3SMG13.35170740
4VRK23.14000859
5ICK3.13696061
6MAP3K103.12798318
7CDC72.58818968
8DDR22.57039117
9WEE12.32121864
10CDK72.29542508
11CDK122.27713450
12MATK2.24485881
13MAPK152.23646615
14EEF2K2.18866877
15NME22.17532795
16MAP3K62.16317571
17IRAK32.14097413
18YES12.14073576
19KDR2.05902439
20FGR2.00515601
21PIM21.97556758
22TYRO31.89096497
23BUB11.83252943
24MAP3K111.69431710
25ERN11.68244416
26BMX1.63832155
27TLK11.63306499
28MKNK11.62317315
29ARAF1.62098873
30PIM11.62023698
31CSF1R1.60431234
32UHMK11.58585502
33TESK11.56120984
34GRK61.55095678
35TESK21.52465173
36DAPK11.50750041
37PBK1.46479016
38TAOK21.44959634
39EIF2AK11.44100899
40MKNK21.40706631
41TTK1.40029729
42SRPK11.38467652
43CHEK21.37991725
44CSK1.35161977
45PLK11.33692734
46DYRK31.32030067
47PAK41.27877430
48BLK1.27235768
49STK101.26791595
50CLK11.26571312
51STK31.25313332
52SIK11.20025207
53NEK21.14208952
54TAF11.08796484
55CDK41.06774185
56PKN21.05246717
57CDK61.04015457
58NEK11.00787691
59CDK80.97015897
60BCKDK0.96681463
61TSSK60.95825188
62STK40.94993048
63VRK10.94431848
64PRKD20.93349929
65BRAF0.93196771
66ACVR1B0.92443508
67MAP2K30.92236421
68RPS6KB20.91266352
69RPS6KA40.86071744
70EPHA20.85731186
71RPS6KC10.84422593
72RPS6KL10.84422593
73DYRK1B0.84244969
74ABL20.83876630
75ATR0.82472127
76AURKA0.79563620
77TRPM70.79412572
78MAP2K20.78503902
79PDGFRA0.78191169
80EPHB20.77648633
81PRPF4B0.74040544
82RPS6KA60.73960864
83IKBKB0.71620332
84STK160.70943171
85* CDK20.68848529
86RIPK40.68726499
87PINK10.68631958
88CHEK10.67326660
89AURKB0.66901295
90ALK0.66438200
91EIF2AK30.63025892
92SIK30.63003591
93HIPK20.62647457
94PLK30.61531940
95CDK90.60279932
96TAOK10.58053805
97CSNK2A10.57828999
98IRAK20.55890413
99CSNK2A20.55575031
100PRKCI0.55573171
101PTK60.55522262
102CDK11A0.52920594
103SCYL20.52698236
104LYN0.52470587
105AKT20.51773870
106GRK50.51358347
107LATS20.50646091
108DMPK0.49737031
109PAK10.47603531
110MAP3K130.47570823
111ATM0.45388396
112MAP3K10.45094654
113ILK0.45069638
114GSK3A0.43956951
115MAP3K80.43788436
116MOS0.42865190
117PTK20.42552923
118PRKD30.41857340
119ADRBK20.41684695
120MAPKAPK20.41542124
121PASK0.40082798
122MAP4K10.39425080
123PLK40.39381712
124MAPK110.38953521
125RAF10.37958663
126NME10.37787874
127RPS6KA10.37544416
128BRSK20.37065897
129CCNB10.36884400
130CDK140.35963372
131MELK0.35718542
132CDK150.35497040
133IRAK40.34871815
134AKT30.32343474
135LRRK20.32150557
136CDK10.31962265
137ERBB30.31919679
138CDK180.31652879
139NTRK10.30964003
140MTOR0.30368065
141TBK10.30336035

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.40483534
2DNA replication_Homo sapiens_hsa030304.37692226
3Ribosome_Homo sapiens_hsa030103.76076700
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36879153
5Base excision repair_Homo sapiens_hsa034103.22145257
6* Spliceosome_Homo sapiens_hsa030403.15698449
7RNA transport_Homo sapiens_hsa030132.59878879
8Nucleotide excision repair_Homo sapiens_hsa034202.54219860
9Homologous recombination_Homo sapiens_hsa034402.45885453
10Proteasome_Homo sapiens_hsa030502.24684863
11RNA polymerase_Homo sapiens_hsa030202.09850684
12Cell cycle_Homo sapiens_hsa041102.05193418
13mRNA surveillance pathway_Homo sapiens_hsa030152.00484213
14Pentose phosphate pathway_Homo sapiens_hsa000301.91385042
15Biosynthesis of amino acids_Homo sapiens_hsa012301.81034269
16Fanconi anemia pathway_Homo sapiens_hsa034601.74302787
17Basal transcription factors_Homo sapiens_hsa030221.53020662
18p53 signaling pathway_Homo sapiens_hsa041151.50618702
19RNA degradation_Homo sapiens_hsa030181.48517556
20Pyrimidine metabolism_Homo sapiens_hsa002401.46230005
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32810250
22Central carbon metabolism in cancer_Homo sapiens_hsa052301.27538013
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26852460
24Carbon metabolism_Homo sapiens_hsa012001.22934130
25One carbon pool by folate_Homo sapiens_hsa006701.21691653
26Shigellosis_Homo sapiens_hsa051311.19683621
27Non-homologous end-joining_Homo sapiens_hsa034501.15715588
28Notch signaling pathway_Homo sapiens_hsa043301.13611610
29Hippo signaling pathway_Homo sapiens_hsa043901.13050402
30Folate biosynthesis_Homo sapiens_hsa007901.11584890
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09470739
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07095892
33Epstein-Barr virus infection_Homo sapiens_hsa051691.01924014
34Hedgehog signaling pathway_Homo sapiens_hsa043401.01889213
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01165748
36N-Glycan biosynthesis_Homo sapiens_hsa005100.97180418
37Colorectal cancer_Homo sapiens_hsa052100.90512000
38Basal cell carcinoma_Homo sapiens_hsa052170.90458724
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89134524
40* Herpes simplex infection_Homo sapiens_hsa051680.88111330
41MicroRNAs in cancer_Homo sapiens_hsa052060.88107660
42Legionellosis_Homo sapiens_hsa051340.87488989
43TGF-beta signaling pathway_Homo sapiens_hsa043500.86539625
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86321540
45Antigen processing and presentation_Homo sapiens_hsa046120.85861197
46Oocyte meiosis_Homo sapiens_hsa041140.85674312
47Viral carcinogenesis_Homo sapiens_hsa052030.85399404
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85130358
49Primary immunodeficiency_Homo sapiens_hsa053400.82281040
50Galactose metabolism_Homo sapiens_hsa000520.81368199
51Adherens junction_Homo sapiens_hsa045200.81341089
52Wnt signaling pathway_Homo sapiens_hsa043100.79239630
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79002675
54mTOR signaling pathway_Homo sapiens_hsa041500.78748994
55Vitamin B6 metabolism_Homo sapiens_hsa007500.78050427
56Fatty acid biosynthesis_Homo sapiens_hsa000610.77619513
57Bladder cancer_Homo sapiens_hsa052190.76489573
58Endometrial cancer_Homo sapiens_hsa052130.73722036
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73642304
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73111114
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73012740
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72754206
63Thyroid cancer_Homo sapiens_hsa052160.71575331
64Acute myeloid leukemia_Homo sapiens_hsa052210.71173401
65HTLV-I infection_Homo sapiens_hsa051660.70515597
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70399161
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.69384156
68B cell receptor signaling pathway_Homo sapiens_hsa046620.65609932
69Leishmaniasis_Homo sapiens_hsa051400.64156715
70Pyruvate metabolism_Homo sapiens_hsa006200.64045626
71Protein export_Homo sapiens_hsa030600.64001391
72Systemic lupus erythematosus_Homo sapiens_hsa053220.61948874
73Chronic myeloid leukemia_Homo sapiens_hsa052200.61120930
74VEGF signaling pathway_Homo sapiens_hsa043700.60199879
75Small cell lung cancer_Homo sapiens_hsa052220.59962821
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59612250
77Other glycan degradation_Homo sapiens_hsa005110.59335072
78Glutathione metabolism_Homo sapiens_hsa004800.59156377
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58936705
80Fatty acid elongation_Homo sapiens_hsa000620.58652373
81Hepatitis B_Homo sapiens_hsa051610.58316202
82Parkinsons disease_Homo sapiens_hsa050120.57382488
83Sulfur relay system_Homo sapiens_hsa041220.57047811
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56573710
85Huntingtons disease_Homo sapiens_hsa050160.54516880
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53540778
87Renal cell carcinoma_Homo sapiens_hsa052110.50660501
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.50274050
89Vibrio cholerae infection_Homo sapiens_hsa051100.50104920
90Apoptosis_Homo sapiens_hsa042100.49173752
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48519003
92Measles_Homo sapiens_hsa051620.48236571
93Pathways in cancer_Homo sapiens_hsa052000.48054708
94Proteoglycans in cancer_Homo sapiens_hsa052050.47246921
95Salmonella infection_Homo sapiens_hsa051320.46195129
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44805674
97Purine metabolism_Homo sapiens_hsa002300.44358676
98Prion diseases_Homo sapiens_hsa050200.43761030
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42764806
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42568267
101Fructose and mannose metabolism_Homo sapiens_hsa000510.42355997
102Phagosome_Homo sapiens_hsa041450.41356634
103Glioma_Homo sapiens_hsa052140.40997792
104Pancreatic cancer_Homo sapiens_hsa052120.40940909
105Renin-angiotensin system_Homo sapiens_hsa046140.40829144
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40660251
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40272177
108Prostate cancer_Homo sapiens_hsa052150.40193464
109Alcoholism_Homo sapiens_hsa050340.39690111
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39195318
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39153861
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.38914404
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38880289
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.38805258
115AMPK signaling pathway_Homo sapiens_hsa041520.38626305
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38367902
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38239331
118ErbB signaling pathway_Homo sapiens_hsa040120.38009220
119Phenylalanine metabolism_Homo sapiens_hsa003600.36803931
120Tuberculosis_Homo sapiens_hsa051520.35573574
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35530443
122African trypanosomiasis_Homo sapiens_hsa051430.35479174
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35402174
124Melanoma_Homo sapiens_hsa052180.34405918
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34161020
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33574802
127Pertussis_Homo sapiens_hsa051330.33526804
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32159394
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31838046
130Arachidonic acid metabolism_Homo sapiens_hsa005900.31555633
131HIF-1 signaling pathway_Homo sapiens_hsa040660.31409168
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.30370519
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30173550
134Tight junction_Homo sapiens_hsa045300.29876186
135Oxidative phosphorylation_Homo sapiens_hsa001900.29708219
136Non-small cell lung cancer_Homo sapiens_hsa052230.27850809
137Dorso-ventral axis formation_Homo sapiens_hsa043200.27524201
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.25114181

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