ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ventricular system development (GO:0021591)	9.20776259
2	microtubule depolymerization (GO:0007019)	8.48418212
3	regulation of cilium movement (GO:0003352)	8.24319354
4	microtubule bundle formation (GO:0001578)	6.37913880
5	left/right pattern formation (GO:0060972)	5.72531979
6	microtubule polymerization or depolymerization (GO:0031109)	5.71325784
7	photoreceptor cell maintenance (GO:0045494)	5.27688409
8	left/right axis specification (GO:0070986)	5.12765661
9	cilium organization (GO:0044782)	4.94767277
10	eye photoreceptor cell development (GO:0042462)	4.66528134
11	regulation of microtubule-based movement (GO:0060632)	4.56704752
12	regulation of DNA endoreduplication (GO:0032875)	4.51608262
13	hepatocyte differentiation (GO:0070365)	4.46875802
14	photoreceptor cell development (GO:0042461)	4.46305934
15	fat-soluble vitamin biosynthetic process (GO:0042362)	4.42803222
16	microtubule-based movement (GO:0007018)	4.32490383
17	intraciliary transport (GO:0042073)	4.27015227
18	brain morphogenesis (GO:0048854)	4.26845664
19	snRNA processing (GO:0016180)	4.15668201
20	cilium assembly (GO:0042384)	4.06415556
21	lateral ventricle development (GO:0021670)	4.04752384
22	cellular component assembly involved in morphogenesis (GO:0010927)	3.85200383
23	regulation of MHC class II biosynthetic process (GO:0045346)	3.77914971
24	snRNA metabolic process (GO:0016073)	3.70504420
25	cilium morphogenesis (GO:0060271)	3.67124117
26	regulation of sarcomere organization (GO:0060297)	3.58137004
27	interkinetic nuclear migration (GO:0022027)	3.55698898
28	ubiquinone biosynthetic process (GO:0006744)	3.49459093
29	peristalsis (GO:0030432)	3.24999725
30	cell projection assembly (GO:0030031)	3.19154016
31	kynurenine metabolic process (GO:0070189)	3.19065264
32	microtubule severing (GO:0051013)	3.18499627
33	ubiquinone metabolic process (GO:0006743)	3.11159172
34	multicellular organismal aging (GO:0010259)	3.03857966
35	cilium or flagellum-dependent cell motility (GO:0001539)	20.1427476
36	protein localization to microtubule cytoskeleton (GO:0072698)	2.95595413
37	quinone biosynthetic process (GO:1901663)	2.93637945
38	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.86277507
39	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.86277507
40	regulation of translation, ncRNA-mediated (GO:0045974)	2.86277507
41	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.81658670
42	protein depolymerization (GO:0051261)	2.81393511
43	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.80255808
44	lysine metabolic process (GO:0006553)	2.79282483
45	lysine catabolic process (GO:0006554)	2.79282483
46	microtubule-based process (GO:0007017)	2.78881950
47	lateral sprouting from an epithelium (GO:0060601)	2.73215551
48	protein localization to cilium (GO:0061512)	2.71978325
49	snRNA transcription (GO:0009301)	2.69918865
50	determination of left/right symmetry (GO:0007368)	2.68761964
51	drug catabolic process (GO:0042737)	2.68169328
52	trophoblast giant cell differentiation (GO:0060707)	2.66623229
53	kidney morphogenesis (GO:0060993)	2.64881174
54	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.62224478
55	protein localization to cytoskeleton (GO:0044380)	2.59566498
56	oxidative demethylation (GO:0070989)	2.58993368
57	determination of bilateral symmetry (GO:0009855)	2.57092038
58	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.52368802
59	regulation of interleukin-5 production (GO:0032674)	2.52273452
60	histone H3 deacetylation (GO:0070932)	2.51100531
61	axis elongation (GO:0003401)	2.51074497
62	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.50350507
63	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.50350507
64	modulation by symbiont of host immune response (GO:0052553)	2.50350507
65	positive regulation by symbiont of host defense response (GO:0052509)	2.50350507
66	modulation by symbiont of host defense response (GO:0052031)	2.50350507
67	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.50350507
68	specification of symmetry (GO:0009799)	2.49722318
69	maintenance of gastrointestinal epithelium (GO:0030277)	2.48275884
70	regulation of timing of cell differentiation (GO:0048505)	2.47386831
71	protein polyglutamylation (GO:0018095)	2.46122346
72	regulation of establishment of planar polarity (GO:0090175)	2.42982807
73	inflammatory response to antigenic stimulus (GO:0002437)	2.41413232
74	pericardium development (GO:0060039)	2.39791062
75	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	2.38460116
76	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.36885831
77	single strand break repair (GO:0000012)	2.31022038
78	phasic smooth muscle contraction (GO:0014821)	2.30633763
79	oxygen transport (GO:0015671)	2.29634059
80	neural tube formation (GO:0001841)	2.27142086
81	nucleus localization (GO:0051647)	2.24217633
82	exogenous drug catabolic process (GO:0042738)	2.24132340
83	vitamin biosynthetic process (GO:0009110)	2.23607812
84	eyelid development in camera-type eye (GO:0061029)	2.20291274
85	early endosome to late endosome transport (GO:0045022)	2.17590982
86	response to host immune response (GO:0052572)	2.16378917
87	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.16378917
88	histone H3-K36 demethylation (GO:0070544)	2.15853838
89	enteric nervous system development (GO:0048484)	2.15271891
90	nonmotile primary cilium assembly (GO:0035058)	2.13507201
91	long term synaptic depression (GO:0060292)	2.12277850
92	sympathetic nervous system development (GO:0048485)	2.08723951
93	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	15.9205012
94	retinal rod cell development (GO:0046548)	14.8410292
95	cilium movement (GO:0003341)	13.6627992
96	retinal cone cell development (GO:0046549)	13.4954647
97	motile cilium assembly (GO:0044458)	13.3029033
98	axoneme assembly (GO:0035082)	13.0339944
99	axonemal dynein complex assembly (GO:0070286)	12.8282201
100	epithelial cilium movement (GO:0003351)	10.6617744

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.98810258
2	AR_21572438_ChIP-Seq_LNCaP_Human	5.65852912
3	IGF1R_20145208_ChIP-Seq_DFB_Human	4.61366417
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.64355563
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.34826483
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78206352
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.64566130
8	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.49851198
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.27905537
10	DROSHA_22980978_ChIP-Seq_HELA_Human	2.26240200
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20443405
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.13219775
13	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.12394636
14	SMAD4_21799915_ChIP-Seq_A2780_Human	2.09813896
15	FOXM1_26456572_ChIP-Seq_MCF-7_Human	2.08587269
16	FUS_26573619_Chip-Seq_HEK293_Human	2.06385595
17	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.99228975
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.94159224
19	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.92258779
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88519285
21	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.88352325
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.86851412
23	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.85731229
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84761546
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.82615133
26	AHR_22903824_ChIP-Seq_MCF-7_Human	1.77089409
27	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.76156695
28	STAT3_23295773_ChIP-Seq_U87_Human	1.75157841
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73405412
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71558903
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.71558903
32	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.70536533
33	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.67350382
34	TP53_16413492_ChIP-PET_HCT116_Human	1.65564419
35	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.64564427
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.62865560
37	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.61135019
38	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.59111024
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.55952018
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.55356469
41	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.52703978
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.52484467
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50241396
44	VDR_22108803_ChIP-Seq_LS180_Human	1.48546728
45	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.47735964
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46263660
47	EWS_26573619_Chip-Seq_HEK293_Human	1.43901953
48	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.36941477
49	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33606835
50	P300_19829295_ChIP-Seq_ESCs_Human	1.29361652
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28584852
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26758331
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26758331
54	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.26221968
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24641831
56	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.22774790
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22210611
58	SMRT_27268052_Chip-Seq_Bcells_Human	1.21865791
59	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.19886206
60	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.19237962
61	TCF4_22108803_ChIP-Seq_LS180_Human	1.18172354
62	TP53_18474530_ChIP-ChIP_U2OS_Human	1.16921452
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.16188162
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15685346
65	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11337099
66	VDR_24787735_ChIP-Seq_THP-1_Human	1.10624077
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10016960
68	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09219941
69	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.09123474
70	TCF4_23295773_ChIP-Seq_U87_Human	1.09097845
71	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.07719513
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07717690
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06729152
74	AR_25329375_ChIP-Seq_VCAP_Human	1.05689859
75	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.05447512
76	KDM2B_26808549_Chip-Seq_REH_Human	1.04396374
77	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.03976995
78	TP53_22573176_ChIP-Seq_HFKS_Human	1.03890136
79	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.02904452
80	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02454256
81	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.01635887
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.01505273
83	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.01326336
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.00863627
85	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.99832637
86	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.99299865
87	BCAT_22108803_ChIP-Seq_LS180_Human	0.98106321
88	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97969269
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96927430
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.96752935
91	AR_20517297_ChIP-Seq_VCAP_Human	0.96691220
92	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.96533045
93	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96314878
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.96161749
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93933707
96	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.91776779
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.91547700
98	AR_19668381_ChIP-Seq_PC3_Human	0.91405134
99	CEBPB_22108803_ChIP-Seq_LS180_Human	0.91351680
100	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.90534521

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	7.27717109
2	MP0001346_abnormal_lacrimal_gland	5.52590191
3	MP0005253_abnormal_eye_physiology	4.19723029
4	MP0005623_abnormal_meninges_morphology	3.98594868
5	MP0000569_abnormal_digit_pigmentation	3.70151199
6	MP0005083_abnormal_biliary_tract	3.51496576
7	MP0003878_abnormal_ear_physiology	3.01235086
8	MP0005377_hearing/vestibular/ear_phenot	3.01235086
9	MP0004043_abnormal_pH_regulation	2.82301664
10	MP0005551_abnormal_eye_electrophysiolog	2.74507767
11	MP0003950_abnormal_plasma_membrane	2.13864052
12	MP0008961_abnormal_basal_metabolism	2.00694884
13	MP0008875_abnormal_xenobiotic_pharmacok	1.99805063
14	MP0005391_vision/eye_phenotype	1.93999604
15	MP0000465_gastrointestinal_hemorrhage	1.92042831
16	MP0005310_abnormal_salivary_gland	1.91642088
17	MP0005195_abnormal_posterior_eye	1.85535323
18	MP0010368_abnormal_lymphatic_system	1.79029667
19	MP0000383_abnormal_hair_follicle	1.76685991
20	MP0002234_abnormal_pharynx_morphology	1.72656533
21	MP0001851_eye_inflammation	1.68817204
22	MP0008057_abnormal_DNA_replication	1.68513011
23	MP0002876_abnormal_thyroid_physiology	1.53242392
24	MP0004145_abnormal_muscle_electrophysio	1.52982666
25	MP0001485_abnormal_pinna_reflex	1.48416242
26	MP0006082_CNS_inflammation	1.47353079
27	MP0001963_abnormal_hearing_physiology	1.44970727
28	MP0002282_abnormal_trachea_morphology	1.42516714
29	MP0006054_spinal_hemorrhage	1.40635803
30	MP0001486_abnormal_startle_reflex	1.35845912
31	MP0002837_dystrophic_cardiac_calcinosis	1.34354797
32	MP0001324_abnormal_eye_pigmentation	1.27184493
33	MP0000631_abnormal_neuroendocrine_gland	1.24931138
34	MP0005646_abnormal_pituitary_gland	1.21146271
35	MP0000490_abnormal_crypts_of	1.18485796
36	MP0000534_abnormal_ureter_morphology	1.16560910
37	MP0002168_other_aberrant_phenotype	1.14861687
38	MP0009384_cardiac_valve_regurgitation	1.14646735
39	MP0003935_abnormal_craniofacial_develop	1.10741220
40	MP0001299_abnormal_eye_distance/	1.10148593
41	MP0005387_immune_system_phenotype	1.08863346
42	MP0001790_abnormal_immune_system	1.08863346
43	MP0002229_neurodegeneration	1.08268998
44	MP0010678_abnormal_skin_adnexa	1.07428998
45	MP0002132_abnormal_respiratory_system	1.05951161
46	MP0009643_abnormal_urine_homeostasis	0.99854488
47	MP0002135_abnormal_kidney_morphology	0.98429978
48	MP0003943_abnormal_hepatobiliary_system	0.97763558
49	MP0002277_abnormal_respiratory_mucosa	0.97495058
50	MP0001177_atelectasis	0.97485926
51	MP0004133_heterotaxia	0.91481823
52	MP0003755_abnormal_palate_morphology	0.91323807
53	MP0002970_abnormal_white_adipose	0.90715511
54	MP0005248_abnormal_Harderian_gland	0.89087319
55	MP0002116_abnormal_craniofacial_bone	0.88446185
56	MP0000566_synostosis	0.88096954
57	MP0009115_abnormal_fat_cell	0.87835790
58	MP0003861_abnormal_nervous_system	0.86629051
59	MP0009765_abnormal_xenobiotic_induced	0.85673434
60	MP0000733_abnormal_muscle_development	0.85633792
61	MP0002405_respiratory_system_inflammati	0.84756391
62	MP0004215_abnormal_myocardial_fiber	0.84635748
63	MP0002133_abnormal_respiratory_system	0.84573521
64	MP0005388_respiratory_system_phenotype	0.84573521
65	MP0002734_abnormal_mechanical_nocicepti	0.83589868
66	MP0009046_muscle_twitch	0.81830363
67	MP0002735_abnormal_chemical_nociception	0.78980631
68	MP0004742_abnormal_vestibular_system	0.78254872
69	MP0003195_calcinosis	0.76202180
70	MP0000516_abnormal_urinary_system	0.75076662
71	MP0005367_renal/urinary_system_phenotyp	0.75076662
72	MP0003137_abnormal_impulse_conducting	0.75005666
73	MP0008995_early_reproductive_senescence	0.74935054
74	MP0002163_abnormal_gland_morphology	0.74657215
75	MP0005395_other_phenotype	0.71993797
76	MP0000026_abnormal_inner_ear	0.69930802
77	MP0002136_abnormal_kidney_physiology	0.67878850
78	MP0002152_abnormal_brain_morphology	0.67749926
79	MP0010329_abnormal_lipoprotein_level	0.66779750
80	MP0004142_abnormal_muscle_tone	0.66632532
81	MP0002148_abnormal_hypersensitivity_rea	0.64300994
82	MP0001666_abnormal_nutrient_absorption	0.63589583
83	MP0008872_abnormal_physiological_respon	0.63527512
84	MP0005167_abnormal_blood-brain_barrier	0.59755366
85	MP0001502_abnormal_circadian_rhythm	0.58748141
86	MP0000432_abnormal_head_morphology	0.58725179
87	MP0003656_abnormal_erythrocyte_physiolo	0.58434866
88	MP0000920_abnormal_myelination	0.57928881
89	MP0002127_abnormal_cardiovascular_syste	0.56524390
90	MP0000751_myopathy	0.55935269
91	MP0001663_abnormal_digestive_system	0.55680205
92	MP0002751_abnormal_autonomic_nervous	0.54980151
93	MP0005076_abnormal_cell_differentiation	0.52417368
94	MP0005452_abnormal_adipose_tissue	0.52281985
95	MP0003690_abnormal_glial_cell	0.52109075
96	MP0005085_abnormal_gallbladder_physiolo	0.50535321
97	MP0003806_abnormal_nucleotide_metabolis	0.50399562
98	MP0003567_abnormal_fetal_cardiomyocyte	0.49458388
99	MP0001970_abnormal_pain_threshold	0.49319744
100	MP0003942_abnormal_urinary_system	0.48346790

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	9.09949719
2	Abnormal ciliary motility (HP:0012262)	8.89091516
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	8.85708912
4	Abnormal respiratory motile cilium morphology (HP:0005938)	8.19037762
5	Abnormal respiratory epithelium morphology (HP:0012253)	8.19037762
6	Abnormal respiratory motile cilium physiology (HP:0012261)	7.74023831
7	Chronic bronchitis (HP:0004469)	5.97078112
8	Chronic hepatic failure (HP:0100626)	5.66358279
9	Abnormal rod and cone electroretinograms (HP:0008323)	5.63934288
10	Tubulointerstitial nephritis (HP:0001970)	5.47749929
11	Rhinitis (HP:0012384)	5.10330566
12	Nasal polyposis (HP:0100582)	4.80560925
13	Bronchiectasis (HP:0002110)	4.75681054
14	Bronchitis (HP:0012387)	4.62616873
15	Constricted visual fields (HP:0001133)	4.15754278
16	Abnormality of the nasal mucosa (HP:0000433)	3.99896698
17	Bony spicule pigmentary retinopathy (HP:0007737)	3.99625128
18	Abnormal hair whorl (HP:0010721)	3.79477007
19	Recurrent bronchitis (HP:0002837)	3.70174770
20	Recurrent sinusitis (HP:0011108)	3.67851253
21	Cone-rod dystrophy (HP:0000548)	3.31399380
22	Anteriorly placed anus (HP:0001545)	3.13761616
23	Recurrent otitis media (HP:0000403)	3.11111806
24	Progressive sensorineural hearing impairment (HP:0000408)	2.96524833
25	Chronic sinusitis (HP:0011109)	2.68788943
26	Decreased circulating renin level (HP:0003351)	2.63365700
27	Hypoalphalipoproteinemia (HP:0003233)	2.55966791
28	Abnormality of the fingertips (HP:0001211)	2.51376948
29	Menstrual irregularities (HP:0000858)	2.46711560
30	Renovascular hypertension (HP:0100817)	2.42564965
31	Tubulointerstitial abnormality (HP:0001969)	2.38505822
32	Long nose (HP:0003189)	2.35960525
33	Hyperactive renin-angiotensin system (HP:0000841)	2.34331463
34	Nephronophthisis (HP:0000090)	2.28999775
35	Premature skin wrinkling (HP:0100678)	2.26658408
36	Nephrogenic diabetes insipidus (HP:0009806)	2.23379300
37	Increased purine levels (HP:0004368)	2.09227697
38	Hyperuricemia (HP:0002149)	2.09227697
39	Recurrent pneumonia (HP:0006532)	2.05962529
40	Macroorchidism (HP:0000053)	2.00736918
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	13.3302168
42	Absent/shortened dynein arms (HP:0200106)	13.3302168
43	Abnormality of midbrain morphology (HP:0002418)	1.96466470
44	Molar tooth sign on MRI (HP:0002419)	1.96466470
45	Abnormality of the renal medulla (HP:0100957)	1.94048022
46	Infertility (HP:0000789)	1.90761051
47	Anal stenosis (HP:0002025)	1.90291180
48	Aortic aneurysm (HP:0004942)	1.89530797
49	Hepatitis (HP:0012115)	1.83905907
50	Portal hypertension (HP:0001409)	1.83176041
51	Insulin-resistant diabetes mellitus (HP:0000831)	1.82891238
52	Lissencephaly (HP:0001339)	1.78506618
53	Partial agenesis of the corpus callosum (HP:0001338)	1.76879948
54	Deep philtrum (HP:0002002)	1.72776115
55	Medial flaring of the eyebrow (HP:0010747)	1.71754801
56	Large for gestational age (HP:0001520)	1.70954014
57	Congenital primary aphakia (HP:0007707)	1.69739624
58	Gingivitis (HP:0000230)	1.69336335
59	Hypoplastic nipples (HP:0002557)	1.66910081
60	Abnormality of the hepatic vasculature (HP:0006707)	1.66872845
61	Gait imbalance (HP:0002141)	1.65005405
62	High pitched voice (HP:0001620)	1.64119414
63	Progressive hearing impairment (HP:0001730)	1.59721854
64	Pancreatic fibrosis (HP:0100732)	1.57760514
65	Scanning speech (HP:0002168)	1.55353375
66	Growth hormone deficiency (HP:0000824)	1.54109331
67	Nephrocalcinosis (HP:0000121)	1.53093463
68	Renal salt wasting (HP:0000127)	1.52463271
69	Truncal obesity (HP:0001956)	1.52162773
70	Supernumerary spleens (HP:0009799)	1.50694624
71	Heterotopia (HP:0002282)	1.49510462
72	Subcapsular cataract (HP:0000523)	1.48869180
73	Hyperaldosteronism (HP:0000859)	1.48314497
74	Recurrent lower respiratory tract infections (HP:0002783)	1.45947187
75	Atelectasis (HP:0100750)	1.45266377
76	Retinitis pigmentosa (HP:0000510)	1.44800510
77	Delayed closure of the anterior fontanelle (HP:0001476)	1.44758165
78	Obsessive-compulsive behavior (HP:0000722)	1.43763624
79	Protruding tongue (HP:0010808)	1.43035203
80	Genital tract atresia (HP:0001827)	1.42928452
81	Ectopic anus (HP:0004397)	1.41901942
82	Vaginal atresia (HP:0000148)	1.39359727
83	Astrocytoma (HP:0009592)	1.38992787
84	Abnormality of the astrocytes (HP:0100707)	1.38992787
85	True hermaphroditism (HP:0010459)	1.38959921
86	Hypokalemic alkalosis (HP:0001949)	1.35217068
87	Open mouth (HP:0000194)	1.34792751
88	Hyperventilation (HP:0002883)	1.33322766
89	Occipital encephalocele (HP:0002085)	1.30361946
90	Hip dysplasia (HP:0001385)	1.27748941
91	Abnormality of renin-angiotensin system (HP:0000847)	1.27736407
92	Poor coordination (HP:0002370)	1.26641434
93	Glioma (HP:0009733)	1.23471128
94	Conjugated hyperbilirubinemia (HP:0002908)	1.20942831
95	Bell-shaped thorax (HP:0001591)	1.20679050
96	Hypergonadotropic hypogonadism (HP:0000815)	1.19814906
97	Congenital hepatic fibrosis (HP:0002612)	1.18220960
98	Ependymoma (HP:0002888)	1.17526381
99	Chronic otitis media (HP:0000389)	1.17051788
100	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.16951554

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCR	4.63811951
2	CDK12	4.16729059
3	STK16	3.90530626
4	MAPK15	3.74061124
5	MAP4K2	3.22446400
6	TYK2	3.01144175
7	TAOK1	2.85127098
8	IRAK1	2.60596992
9	EPHA3	2.57211503
10	ERBB2	2.24700962
11	STK38L	2.13297915
12	IRAK2	1.87744211
13	MST4	1.83275447
14	STK10	1.80934780
15	FRK	1.80262522
16	VRK2	1.76388899
17	SGK2	1.72092214
18	MARK1	1.70563977
19	PNCK	1.69257769
20	MAPK13	1.59778082
21	CAMK1G	1.51125389
22	UHMK1	1.41526372
23	BLK	1.34038043
24	RPS6KA2	1.28634762
25	DYRK1B	1.27440041
26	IRAK4	1.20863810
27	RPS6KA6	1.20758753
28	CAMK1D	1.19842043
29	EPHA4	1.15514384
30	SGK223	1.12796983
31	SGK494	1.12796983
32	RPS6KC1	1.12285224
33	RPS6KL1	1.12285224
34	ERN1	1.10395528
35	MARK2	1.10049876
36	MST1R	1.06208809
37	MET	1.04726664
38	CSNK1A1L	1.03828481
39	STK11	1.03658295
40	TTK	1.03591262
41	WEE1	1.02605589
42	STK3	0.98931393
43	PTK6	0.95828414
44	TRIM28	0.92444852
45	MUSK	0.91273774
46	LRRK2	0.88259380
47	STK38	0.88109870
48	IKBKE	0.87120607
49	SGK3	0.86829587
50	CDC42BPA	0.81277730
51	CSNK1G2	0.76946546
52	MAP3K7	0.75656963
53	ZAP70	0.75645374
54	MAPKAPK2	0.74657495
55	IKBKB	0.72978463
56	CAMK4	0.72243272
57	DAPK2	0.70779345
58	PAK3	0.70684728
59	CDK8	0.70434913
60	CCNB1	0.68669892
61	OXSR1	0.66119373
62	BUB1	0.64244569
63	TGFBR1	0.62970558
64	CDK7	0.62069318
65	PKN1	0.61728940
66	MAPK4	0.59928677
67	NEK2	0.59628966
68	PIK3CA	0.57899793
69	BRD4	0.56905002
70	MAP3K2	0.56812305
71	TNK2	0.53916355
72	FER	0.50110041
73	AURKA	0.49887525
74	PLK4	0.49853117
75	STK4	0.49327505
76	ADRBK2	0.48464531
77	CHEK2	0.47842847
78	MAPK8	0.47735587
79	YES1	0.46600321
80	VRK1	0.46552636
81	MAP3K3	0.43301162
82	EGFR	0.43224401
83	TBK1	0.43114371
84	ATM	0.43026727
85	DYRK1A	0.41793381
86	ADRBK1	0.40863766
87	LATS1	0.40860610
88	MAP3K8	0.39941950
89	PRKD2	0.39829369
90	PRKCI	0.39085349
91	CASK	0.36833822
92	CAMK1	0.35266512
93	PIM1	0.34959957
94	ROCK1	0.34116828
95	FYN	0.33562767
96	CDK6	0.33158840
97	PLK1	0.32054583
98	HIPK2	0.30670169
99	WNK3	0.30619401
100	CSK	0.29263160

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	4.70045704
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.85304637
3	ABC transporters_Homo sapiens_hsa02010	2.76905281
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.74543398
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.66576652
6	Notch signaling pathway_Homo sapiens_hsa04330	2.43493306
7	Huntingtons disease_Homo sapiens_hsa05016	2.35897570
8	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.28063846
9	Lysine degradation_Homo sapiens_hsa00310	2.21201757
10	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.20594661
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.94902529
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.92055290
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.86042574
14	Histidine metabolism_Homo sapiens_hsa00340	1.81922988
15	Retinol metabolism_Homo sapiens_hsa00830	1.81501623
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.75499947
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.72078064
18	Sphingolipid metabolism_Homo sapiens_hsa00600	1.70819316
19	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.63586930
20	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.59461392
21	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.57521328
22	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.51842070
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.46977047
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.44305313
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.43894434
26	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.41404700
27	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.41325272
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29812413
29	Basal transcription factors_Homo sapiens_hsa03022	1.29329876
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.27482454
31	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.24842031
32	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.12020231
33	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.10369924
34	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01597061
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.93887067
36	Cell cycle_Homo sapiens_hsa04110	0.93609107
37	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.92300281
38	Homologous recombination_Homo sapiens_hsa03440	0.91422125
39	TNF signaling pathway_Homo sapiens_hsa04668	0.89641022
40	ErbB signaling pathway_Homo sapiens_hsa04012	0.79637781
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.79086418
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78632456
43	ECM-receptor interaction_Homo sapiens_hsa04512	0.76130982
44	African trypanosomiasis_Homo sapiens_hsa05143	0.75529370
45	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.75110304
46	Primary immunodeficiency_Homo sapiens_hsa05340	0.74893779
47	Small cell lung cancer_Homo sapiens_hsa05222	0.74696596
48	Circadian rhythm_Homo sapiens_hsa04710	0.72107571
49	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.66753995
50	p53 signaling pathway_Homo sapiens_hsa04115	0.66280710
51	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62049486
52	Salivary secretion_Homo sapiens_hsa04970	0.61876189
53	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.61117548
54	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60551595
55	Complement and coagulation cascades_Homo sapiens_hsa04610	0.58840320
56	Serotonergic synapse_Homo sapiens_hsa04726	0.56158705
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.56098597
58	Amoebiasis_Homo sapiens_hsa05146	0.55068736
59	Adherens junction_Homo sapiens_hsa04520	0.54636220
60	Prolactin signaling pathway_Homo sapiens_hsa04917	0.54054570
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54042879
62	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53934986
63	Tuberculosis_Homo sapiens_hsa05152	0.48245044
64	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.48009011
65	MicroRNAs in cancer_Homo sapiens_hsa05206	0.46320080
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45858034
67	Nicotine addiction_Homo sapiens_hsa05033	0.45635228
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.45331523
69	Chemokine signaling pathway_Homo sapiens_hsa04062	0.44213896
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43906454
71	Pentose phosphate pathway_Homo sapiens_hsa00030	0.43792145
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42852483
73	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.42031205
74	Axon guidance_Homo sapiens_hsa04360	0.41426484
75	Lysosome_Homo sapiens_hsa04142	0.40748681
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.40709845
77	Platelet activation_Homo sapiens_hsa04611	0.40466846
78	Peroxisome_Homo sapiens_hsa04146	0.39974268
79	Fatty acid degradation_Homo sapiens_hsa00071	0.39631559
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.39281983
81	Allograft rejection_Homo sapiens_hsa05330	0.38787993
82	Viral carcinogenesis_Homo sapiens_hsa05203	0.38094174
83	Asthma_Homo sapiens_hsa05310	0.38054118
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35894987
85	Graft-versus-host disease_Homo sapiens_hsa05332	0.35556477
86	Pathways in cancer_Homo sapiens_hsa05200	0.35415198
87	Antigen processing and presentation_Homo sapiens_hsa04612	0.35356823
88	Caffeine metabolism_Homo sapiens_hsa00232	0.35097403
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.34787403
90	Taste transduction_Homo sapiens_hsa04742	0.33977046
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.33713544
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.33113039
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32826963
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.32575773
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.30249359
96	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.29188366
97	Osteoclast differentiation_Homo sapiens_hsa04380	0.29094580
98	Cocaine addiction_Homo sapiens_hsa05030	0.28225223
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27517977
100	Rap1 signaling pathway_Homo sapiens_hsa04015	0.27183905

SRSF9P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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