SRY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.96424635
2detection of light stimulus involved in sensory perception (GO:0050962)6.47782372
3detection of light stimulus involved in visual perception (GO:0050908)6.47782372
4retinal cone cell development (GO:0046549)6.29020746
5neuron fate determination (GO:0048664)5.14041698
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.06340291
7negative regulation of cytosolic calcium ion concentration (GO:0051481)5.00621796
8eye photoreceptor cell development (GO:0042462)4.98031709
9photoreceptor cell development (GO:0042461)4.97609488
10regulation of rhodopsin mediated signaling pathway (GO:0022400)4.91362705
11G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.90536535
12DNA integration (GO:0015074)4.89010840
13rhodopsin mediated signaling pathway (GO:0016056)4.87760266
14positive regulation of synapse maturation (GO:0090129)4.81332848
15somite development (GO:0061053)4.71213816
16substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.54686292
17substrate-independent telencephalic tangential migration (GO:0021826)4.54686292
18adenine nucleotide transport (GO:0051503)4.48927789
19sodium ion export (GO:0071436)4.39333437
20retinal rod cell development (GO:0046548)4.35920289
21purine ribonucleotide transport (GO:0015868)4.35012057
22regulation of synapse maturation (GO:0090128)4.25556886
23photoreceptor cell maintenance (GO:0045494)4.16971390
24epithelial cilium movement (GO:0003351)4.08510877
25regulation of chemokine-mediated signaling pathway (GO:0070099)4.07494397
26establishment of protein localization to mitochondrial membrane (GO:0090151)4.07027844
27response to nitrosative stress (GO:0051409)4.02810948
28axonal fasciculation (GO:0007413)4.01900191
29anatomical structure regression (GO:0060033)4.00186993
30kidney morphogenesis (GO:0060993)3.99717811
31neurotransmitter-gated ion channel clustering (GO:0072578)3.95306851
32purine nucleotide transport (GO:0015865)3.86366896
33positive regulation of guanylate cyclase activity (GO:0031284)3.82729775
34presynaptic membrane organization (GO:0097090)3.81796830
35negative regulation of osteoblast proliferation (GO:0033689)3.80839208
36cell communication by electrical coupling (GO:0010644)3.77243886
37intraciliary transport (GO:0042073)3.73897686
38neuronal ion channel clustering (GO:0045161)3.65211403
39protein neddylation (GO:0045116)3.64019733
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63943227
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.63792749
42axon ensheathment in central nervous system (GO:0032291)3.61661432
43central nervous system myelination (GO:0022010)3.61661432
44regulation of mesoderm development (GO:2000380)3.60046957
45nonmotile primary cilium assembly (GO:0035058)3.57069823
46protein localization to synapse (GO:0035418)3.52614103
47mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52230922
48atrial cardiac muscle cell action potential (GO:0086014)3.50586406
49regulation of non-canonical Wnt signaling pathway (GO:2000050)3.49996999
50chromatin remodeling at centromere (GO:0031055)3.48343755
51sequestering of actin monomers (GO:0042989)3.48150034
52lung-associated mesenchyme development (GO:0060484)3.45132902
53righting reflex (GO:0060013)3.41753154
54protein polyglutamylation (GO:0018095)3.40743827
55detection of bacterium (GO:0016045)3.40329493
56regulation of guanylate cyclase activity (GO:0031282)3.39869964
57striatum development (GO:0021756)3.38496652
58regulation of voltage-gated calcium channel activity (GO:1901385)3.35459758
59lactate metabolic process (GO:0006089)3.32535701
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31314709
61ribosomal small subunit assembly (GO:0000028)3.30645834
62CENP-A containing nucleosome assembly (GO:0034080)3.28441288
63cilium movement (GO:0003341)3.28233783
64regulation of cGMP metabolic process (GO:0030823)3.25687434
65ATP synthesis coupled proton transport (GO:0015986)3.24258585
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24258585
67behavioral response to ethanol (GO:0048149)3.24080379
68dorsal/ventral axis specification (GO:0009950)3.21590597
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.21217301
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17998896
71detection of other organism (GO:0098543)3.17878491
72somite rostral/caudal axis specification (GO:0032525)3.17201937
73retinal ganglion cell axon guidance (GO:0031290)3.16539572
74negative regulation of leukocyte chemotaxis (GO:0002689)3.12399973
75tongue development (GO:0043586)3.12039536
76water-soluble vitamin biosynthetic process (GO:0042364)3.10974572
77aldehyde catabolic process (GO:0046185)3.10930346
78spliceosomal complex assembly (GO:0000245)3.09925993
79reflex (GO:0060004)3.09881186
80negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.07772434
81positive regulation of cGMP biosynthetic process (GO:0030828)3.04435540
82neuronal stem cell maintenance (GO:0097150)3.04258392
83forebrain neuron differentiation (GO:0021879)3.04100063
84nucleoside transport (GO:0015858)3.03250460
85dorsal/ventral pattern formation (GO:0009953)3.02279316
86positive regulation of type 2 immune response (GO:0002830)3.01621922
87radial glial cell differentiation (GO:0060019)2.99635070
88regulation of cell fate specification (GO:0042659)2.97739847
89organ formation (GO:0048645)2.94989872
90positive regulation of cGMP metabolic process (GO:0030825)2.94742780
91innervation (GO:0060384)2.93949972
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.92864908
93regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.92864908
94GPI anchor metabolic process (GO:0006505)2.92671886
95behavioral response to cocaine (GO:0048148)2.92125351
96protein heterotetramerization (GO:0051290)2.91400008
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.90178930
98positive regulation of action potential (GO:0045760)2.89472148
99negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.89069493
100sensory perception of light stimulus (GO:0050953)2.88526200
101detection of light stimulus (GO:0009583)2.87878579
102establishment of planar polarity (GO:0001736)2.86585198
103establishment of tissue polarity (GO:0007164)2.86585198
104pituitary gland development (GO:0021983)2.85799400
105relaxation of smooth muscle (GO:0044557)2.85506392
106cilium or flagellum-dependent cell motility (GO:0001539)2.85405962
107neural tube formation (GO:0001841)2.85347452
108calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.85012654
109regulation of mononuclear cell migration (GO:0071675)2.84847384
110prenylation (GO:0097354)2.84359992
111protein prenylation (GO:0018342)2.84359992
112positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.84280949
113visual perception (GO:0007601)2.83967615
114neuron recognition (GO:0008038)2.82784204
115regulation of cGMP biosynthetic process (GO:0030826)2.82593113
116regulation of gastrulation (GO:0010470)2.82472355
117adult feeding behavior (GO:0008343)2.82456348
118response to peptidoglycan (GO:0032494)2.81042091
119GPI anchor biosynthetic process (GO:0006506)2.80947171
120cholesterol biosynthetic process (GO:0006695)2.80451992
121positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.78926144
122L-serine metabolic process (GO:0006563)2.78676165
123protein complex biogenesis (GO:0070271)2.77979892
124DNA ligation (GO:0006266)2.77132785
125postsynaptic membrane organization (GO:0001941)2.76810511
126lateral sprouting from an epithelium (GO:0060601)2.75457077
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74233291
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.74233291
129NADH dehydrogenase complex assembly (GO:0010257)2.74233291
130regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.72688527
131synaptic vesicle endocytosis (GO:0048488)2.72332541
132positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.72183203
133DNA replication-independent nucleosome assembly (GO:0006336)2.71729181
134DNA replication-independent nucleosome organization (GO:0034724)2.71729181
135response to histamine (GO:0034776)2.71356809
136behavioral response to nicotine (GO:0035095)2.71232282
137DNA double-strand break processing (GO:0000729)2.69962547
138epithelial cell maturation (GO:0002070)2.68927840
139sterol biosynthetic process (GO:0016126)2.68742010
140lung epithelium development (GO:0060428)2.68552245
141regulation of tolerance induction (GO:0002643)2.68327392
142regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68183833
143regulation of dopamine metabolic process (GO:0042053)2.67897934
144regulation of catecholamine metabolic process (GO:0042069)2.67897934
145serine family amino acid catabolic process (GO:0009071)2.67547346
146regulation of cilium movement (GO:0003352)2.66024647
147photoreceptor cell differentiation (GO:0046530)2.65745784
148eye photoreceptor cell differentiation (GO:0001754)2.65745784
149regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.65090923
150synaptic transmission, dopaminergic (GO:0001963)2.64750406
151histone exchange (GO:0043486)2.64056188
152limb bud formation (GO:0060174)2.63257915
153tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62747111
154RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62747111
155regulation of mesenchymal cell apoptotic process (GO:2001053)2.62719716
156cilium morphogenesis (GO:0060271)2.62601604
157positive regulation of circadian rhythm (GO:0042753)2.62305383
158neuron cell-cell adhesion (GO:0007158)2.62271819
159chaperone-mediated protein transport (GO:0072321)2.62022981
160lens fiber cell development (GO:0070307)2.61749559
161synaptic vesicle exocytosis (GO:0016079)2.61614519
162regulation of interleukin-6 biosynthetic process (GO:0045408)2.61379567
163axon extension involved in axon guidance (GO:0048846)2.59344790
164neuron projection extension involved in neuron projection guidance (GO:1902284)2.59344790
165smoothened signaling pathway (GO:0007224)2.58642434
166seminiferous tubule development (GO:0072520)2.58119567
167detection of visible light (GO:0009584)2.58062032
168regulation of response to food (GO:0032095)2.57365794
169negative regulation of appetite (GO:0032099)2.56717329
170negative regulation of response to food (GO:0032096)2.56717329
171ectoderm development (GO:0007398)2.56222936
172cellular response to leptin stimulus (GO:0044320)2.55976450
173SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54021084
174cotranslational protein targeting to membrane (GO:0006613)2.52586306
175mitochondrial respiratory chain complex assembly (GO:0033108)2.52573896
176kinetochore organization (GO:0051383)2.52111566
177negative regulation of axon guidance (GO:1902668)2.51594592
178detection of chemical stimulus involved in sensory perception (GO:0050907)2.51501242
179kinetochore assembly (GO:0051382)2.50348407
180cilium assembly (GO:0042384)2.50040373
181embryonic foregut morphogenesis (GO:0048617)2.49830189
182phototransduction (GO:0007602)2.49496401
183dopamine transport (GO:0015872)2.49334587
184regulation of development, heterochronic (GO:0040034)2.48618183
185regulation of T-helper 2 cell differentiation (GO:0045628)2.48518093
186cilium organization (GO:0044782)2.48084102
187regulation of cell fate commitment (GO:0010453)2.48039296
188non-recombinational repair (GO:0000726)2.47916515
189double-strand break repair via nonhomologous end joining (GO:0006303)2.47916515
190mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46164187
191metanephric tubule development (GO:0072170)2.45388189
192metanephric nephron tubule development (GO:0072234)2.45388189
193cell proliferation in forebrain (GO:0021846)2.44887970
194protein targeting to ER (GO:0045047)2.44284560
195negative regulation of astrocyte differentiation (GO:0048712)2.42032404

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.01446077
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.36833055
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.85988465
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.49603243
5EZH2_22144423_ChIP-Seq_EOC_Human3.35854051
6EED_16625203_ChIP-ChIP_MESCs_Mouse3.13454399
7GBX2_23144817_ChIP-Seq_PC3_Human3.08812876
8IGF1R_20145208_ChIP-Seq_DFB_Human3.07833389
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.04298918
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.87380458
11ZNF274_21170338_ChIP-Seq_K562_Hela2.82028563
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.81115564
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80610406
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.80351906
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78063720
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.67879155
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.66600581
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62166005
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59588724
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53650804
21FUS_26573619_Chip-Seq_HEK293_Human2.53038372
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.47629876
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42732598
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42661206
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.41717016
26EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39174120
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39174120
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25642262
29DROSHA_22980978_ChIP-Seq_HELA_Human2.23533737
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23358021
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.23055215
32CBX2_27304074_Chip-Seq_ESCs_Mouse2.15702834
33EWS_26573619_Chip-Seq_HEK293_Human2.14615445
34AR_21572438_ChIP-Seq_LNCaP_Human2.12463707
35GABP_17652178_ChIP-ChIP_JURKAT_Human2.09110674
36TAF15_26573619_Chip-Seq_HEK293_Human2.05175481
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.01545953
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01303916
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99702912
40* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98490029
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92295890
42VDR_22108803_ChIP-Seq_LS180_Human1.85558612
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85320021
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.84760268
45IRF1_19129219_ChIP-ChIP_H3396_Human1.80636286
46RNF2_27304074_Chip-Seq_NSC_Mouse1.80342851
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77041021
48MYC_18940864_ChIP-ChIP_HL60_Human1.74755066
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.71298656
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.69716593
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67422497
52P53_22127205_ChIP-Seq_FIBROBLAST_Human1.61836146
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61337109
54REST_21632747_ChIP-Seq_MESCs_Mouse1.60998646
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60173909
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59853804
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59652460
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.56401192
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55550761
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55385465
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.55152050
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.45261569
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45178192
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44887587
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44562894
66* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42617724
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.42594659
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.41696074
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.36328562
70P300_19829295_ChIP-Seq_ESCs_Human1.34490269
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30800699
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30559082
73ELK1_19687146_ChIP-ChIP_HELA_Human1.29332522
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29229284
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28611736
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28146270
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24055340
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23933162
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22907004
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22070393
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20975082
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19598756
83CBP_20019798_ChIP-Seq_JUKART_Human1.19598756
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17583436
85* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17249612
86NANOG_19829295_ChIP-Seq_ESCs_Human1.15687357
87SOX2_19829295_ChIP-Seq_ESCs_Human1.15687357
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15364584
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14152559
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14124406
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14097928
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13078606
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.12753875
94VDR_23849224_ChIP-Seq_CD4+_Human1.12734929
95SMAD4_21799915_ChIP-Seq_A2780_Human1.11242019
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10587360
97STAT3_23295773_ChIP-Seq_U87_Human1.10492055
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09241674
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08744202
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08618096
101TCF4_22108803_ChIP-Seq_LS180_Human1.07603670
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.07317761
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06615043
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.06368500
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04765931
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03846053
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03838354
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02627566
109TP53_22573176_ChIP-Seq_HFKS_Human1.02444060
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00525830
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.00214431
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99876639
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99698258
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99388288
115EZH2_27294783_Chip-Seq_NPCs_Mouse0.99254262
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98995972
117TP63_19390658_ChIP-ChIP_HaCaT_Human0.98464152
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98418190
119TTF2_22483619_ChIP-Seq_HELA_Human0.95795218
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.95529998
121SOX9_26525672_Chip-Seq_HEART_Mouse0.95365008
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95240899
123FOXP3_21729870_ChIP-Seq_TREG_Human0.94210615
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93776726
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93419655
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93330667
127RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93073187
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93047665
129AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92732321
130RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92223055
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91132527
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.90128592
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.88248365
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.87864386
135STAT3_18555785_Chip-Seq_ESCs_Mouse0.85535045
136PU1_27457419_Chip-Seq_LIVER_Mouse0.84950028
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.84919279
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84137826
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.84084093
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84009893
141SOX2_18555785_Chip-Seq_ESCs_Mouse0.83431502
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.83411777
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.83247657
144P53_22387025_ChIP-Seq_ESCs_Mouse0.83024333
145* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82769450
146AR_25329375_ChIP-Seq_VCAP_Human0.81716735
147HTT_18923047_ChIP-ChIP_STHdh_Human0.81371536
148THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81111512
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.80905903
150RXR_22108803_ChIP-Seq_LS180_Human0.80567539
151* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80472077
152FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80397736
153EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79028818
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78968082
155RUNX2_22187159_ChIP-Seq_PCA_Human0.78080421
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.77601471
157SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.77132007
158IRF8_21731497_ChIP-ChIP_J774_Mouse0.76533893
159KDM2B_26808549_Chip-Seq_REH_Human0.76224363
160E2F1_18555785_Chip-Seq_ESCs_Mouse0.76193796
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75543899
162GF1_26923725_Chip-Seq_HPCs_Mouse0.73954449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous5.24571880
2MP0005551_abnormal_eye_electrophysiolog4.85927776
3MP0001984_abnormal_olfaction3.92318667
4MP0003880_abnormal_central_pattern3.71279880
5MP0005645_abnormal_hypothalamus_physiol3.67854781
6MP0008995_early_reproductive_senescence3.24174894
7MP0001986_abnormal_taste_sensitivity3.21886193
8MP0001346_abnormal_lacrimal_gland3.05688516
9MP0005253_abnormal_eye_physiology2.94239015
10MP0010030_abnormal_orbit_morphology2.67503314
11MP0005171_absent_coat_pigmentation2.66161193
12MP0005646_abnormal_pituitary_gland2.58379938
13MP0006072_abnormal_retinal_apoptosis2.53363127
14MP0002938_white_spotting2.52133385
15MP0000566_synostosis2.48533499
16MP0005248_abnormal_Harderian_gland2.48080572
17MP0003183_abnormal_peptide_metabolism2.40652083
18MP0002090_abnormal_vision2.39187388
19MP0002837_dystrophic_cardiac_calcinosis2.34005699
20MP0001293_anophthalmia2.28412923
21MP0001502_abnormal_circadian_rhythm2.18317359
22MP0008260_abnormal_autophagy2.17633801
23MP0003195_calcinosis2.12119255
24MP0003890_abnormal_embryonic-extraembry2.09904105
25MP0004782_abnormal_surfactant_physiolog2.09658550
26MP0009379_abnormal_foot_pigmentation2.04707840
27MP0009046_muscle_twitch2.04122198
28MP0003941_abnormal_skin_development2.02805508
29MP0001188_hyperpigmentation1.95777834
30MP0000631_abnormal_neuroendocrine_gland1.90786107
31MP0002638_abnormal_pupillary_reflex1.88329679
32MP0003121_genomic_imprinting1.85940327
33MP0008789_abnormal_olfactory_epithelium1.85162645
34MP0003567_abnormal_fetal_cardiomyocyte1.83893284
35MP0000049_abnormal_middle_ear1.72815708
36MP0005310_abnormal_salivary_gland1.67418428
37MP0006292_abnormal_olfactory_placode1.63304656
38MP0003787_abnormal_imprinting1.62734186
39MP0002163_abnormal_gland_morphology1.62610981
40MP0003011_delayed_dark_adaptation1.58933348
41MP0005195_abnormal_posterior_eye1.55583890
42MP0003136_yellow_coat_color1.53595455
43MP0005499_abnormal_olfactory_system1.51160821
44MP0005394_taste/olfaction_phenotype1.51160821
45MP0004133_heterotaxia1.47684548
46MP0001286_abnormal_eye_development1.44146211
47MP0009384_cardiac_valve_regurgitation1.44081195
48MP0003937_abnormal_limbs/digits/tail_de1.41057749
49MP0005379_endocrine/exocrine_gland_phen1.40598461
50MP0001324_abnormal_eye_pigmentation1.40108115
51MP0002653_abnormal_ependyma_morphology1.39204850
52MP0003122_maternal_imprinting1.36526166
53MP0001486_abnormal_startle_reflex1.35723484
54MP0004859_abnormal_synaptic_plasticity1.34823668
55MP0005174_abnormal_tail_pigmentation1.34512408
56MP0001529_abnormal_vocalization1.34485789
57MP0005391_vision/eye_phenotype1.33019479
58MP0002063_abnormal_learning/memory/cond1.32741485
59MP0002752_abnormal_somatic_nervous1.32139763
60MP0000778_abnormal_nervous_system1.31764453
61MP0002277_abnormal_respiratory_mucosa1.31747734
62MP0009764_decreased_sensitivity_to1.29426965
63MP0004742_abnormal_vestibular_system1.29070158
64MP0003172_abnormal_lysosome_physiology1.28382858
65MP0010386_abnormal_urinary_bladder1.26276211
66MP0006276_abnormal_autonomic_nervous1.22031057
67MP0003693_abnormal_embryo_hatching1.20498469
68MP0003646_muscle_fatigue1.17790419
69MP0003878_abnormal_ear_physiology1.17742699
70MP0005377_hearing/vestibular/ear_phenot1.17742699
71MP0000383_abnormal_hair_follicle1.16805414
72MP0002184_abnormal_innervation1.15431222
73MP0003950_abnormal_plasma_membrane1.14495071
74MP0002064_seizures1.12801827
75MP0003786_premature_aging1.12436670
76MP0003119_abnormal_digestive_system1.12139989
77MP0002148_abnormal_hypersensitivity_rea1.10992014
78MP0003635_abnormal_synaptic_transmissio1.10287108
79MP0002876_abnormal_thyroid_physiology1.10224139
80MP0006054_spinal_hemorrhage1.10087894
81MP0009745_abnormal_behavioral_response1.09961570
82MP0008058_abnormal_DNA_repair1.09377562
83MP0002249_abnormal_larynx_morphology1.09255195
84MP0002092_abnormal_eye_morphology1.07737207
85MP0005187_abnormal_penis_morphology1.07698110
86MP0002332_abnormal_exercise_endurance1.06717781
87MP0002882_abnormal_neuron_morphology1.06183725
88MP0000372_irregular_coat_pigmentation1.05736413
89MP0004142_abnormal_muscle_tone1.04353933
90MP0009697_abnormal_copulation1.04014008
91MP0002272_abnormal_nervous_system1.01847135
92MP0002009_preneoplasia1.00477881
93MP0003755_abnormal_palate_morphology0.99354949
94MP0002697_abnormal_eye_size0.98835263
95MP0001485_abnormal_pinna_reflex0.98109378
96MP0005197_abnormal_uvea_morphology0.96903685
97MP0000026_abnormal_inner_ear0.96837523
98MP0003137_abnormal_impulse_conducting0.95125756
99MP0008877_abnormal_DNA_methylation0.94343927
100MP0010094_abnormal_chromosome_stability0.93335461
101MP0003123_paternal_imprinting0.92245836
102MP0002095_abnormal_skin_pigmentation0.90906986
103MP0000428_abnormal_craniofacial_morphol0.88818302
104MP0001299_abnormal_eye_distance/0.88514648
105MP0002572_abnormal_emotion/affect_behav0.85332466
106MP0002557_abnormal_social/conspecific_i0.84945490
107MP0006082_CNS_inflammation0.84430022
108MP0001963_abnormal_hearing_physiology0.84229906
109MP0002736_abnormal_nociception_after0.82864255
110MP0005670_abnormal_white_adipose0.81986683
111MP0000579_abnormal_nail_morphology0.81887637
112MP0008932_abnormal_embryonic_tissue0.81396450
113MP0004381_abnormal_hair_follicle0.81043101
114MP0002751_abnormal_autonomic_nervous0.80635072
115MP0002102_abnormal_ear_morphology0.80484126
116MP0002234_abnormal_pharynx_morphology0.80198007
117MP0002116_abnormal_craniofacial_bone0.79763087
118MP0009053_abnormal_anal_canal0.79458754
119MP0001727_abnormal_embryo_implantation0.78864394
120MP0002067_abnormal_sensory_capabilities0.77925533
121MP0002928_abnormal_bile_duct0.76195386
122MP0003938_abnormal_ear_development0.76172889
123MP0004147_increased_porphyrin_level0.75157625
124MP0002111_abnormal_tail_morphology0.74780434
125MP0010678_abnormal_skin_adnexa0.73725728
126MP0001970_abnormal_pain_threshold0.73386080
127MP0009785_altered_susceptibility_to0.72934012
128MP0000534_abnormal_ureter_morphology0.72683676
129MP0002282_abnormal_trachea_morphology0.72232509
130MP0002998_abnormal_bone_remodeling0.72136513
131MP0001440_abnormal_grooming_behavior0.72072378
132MP0003942_abnormal_urinary_system0.69645064
133MP0003861_abnormal_nervous_system0.67665227
134MP0003283_abnormal_digestive_organ0.67220485
135MP0005595_abnormal_vascular_smooth0.66389290
136MP0004145_abnormal_muscle_electrophysio0.66272448
137MP0000647_abnormal_sebaceous_gland0.64891589
138MP0002733_abnormal_thermal_nociception0.64771074
139MP0004811_abnormal_neuron_physiology0.62421179
140* MP0000653_abnormal_sex_gland0.61690453
141MP0001968_abnormal_touch/_nociception0.61404424
142MP0003315_abnormal_perineum_morphology0.61320517
143MP0002233_abnormal_nose_morphology0.60318612
144* MP0002210_abnormal_sex_determination0.59483523
145MP0003436_decreased_susceptibility_to0.59074656
146MP0000955_abnormal_spinal_cord0.58117910
147MP0002229_neurodegeneration0.57682897
148MP0001905_abnormal_dopamine_level0.57528250
149MP0005409_darkened_coat_color0.56454820
150MP0002109_abnormal_limb_morphology0.55846899
151MP0002069_abnormal_eating/drinking_beha0.55284268
152MP0002419_abnormal_innate_immunity0.55167479
153MP0001835_abnormal_antigen_presentation0.54646840
154MP0002152_abnormal_brain_morphology0.53580643
155MP0008961_abnormal_basal_metabolism0.53564154
156MP0000163_abnormal_cartilage_morphology0.53316334

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.51411115
2Colon cancer (HP:0003003)4.99302440
3Pigmentary retinal degeneration (HP:0001146)4.91470722
4Hyperglycinemia (HP:0002154)4.77059795
5Keratoconus (HP:0000563)4.45294486
6Increased corneal curvature (HP:0100692)4.45294486
7Decreased central vision (HP:0007663)4.29772200
8Abnormal rod and cone electroretinograms (HP:0008323)4.10008522
9Pancreatic fibrosis (HP:0100732)4.00152727
10Molar tooth sign on MRI (HP:0002419)3.67911144
11Abnormality of midbrain morphology (HP:0002418)3.67911144
12Bony spicule pigmentary retinopathy (HP:0007737)3.55676353
13Supernumerary spleens (HP:0009799)3.43512489
14Aplasia/Hypoplasia of the tongue (HP:0010295)3.40679976
15Gait imbalance (HP:0002141)3.40431699
16Tetraparesis (HP:0002273)3.40268214
17Congenital primary aphakia (HP:0007707)3.23534679
18Nephronophthisis (HP:0000090)3.19883032
19Aplasia/Hypoplasia of the fovea (HP:0008060)3.19173311
20Hypoplasia of the fovea (HP:0007750)3.19173311
21Abnormality of the proximal phalanges of the hand (HP:0009834)3.10823766
22Nephrogenic diabetes insipidus (HP:0009806)3.10629762
23Medial flaring of the eyebrow (HP:0010747)3.09335765
24Abnormality of macular pigmentation (HP:0008002)3.03347543
25Febrile seizures (HP:0002373)3.01230804
26Abnormal biliary tract physiology (HP:0012439)2.99042426
27Bile duct proliferation (HP:0001408)2.99042426
28Attenuation of retinal blood vessels (HP:0007843)2.94431226
29Absent septum pellucidum (HP:0001331)2.93658682
30Polyphagia (HP:0002591)2.91126727
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.90549821
32Abnormal eating behavior (HP:0100738)2.89508068
33Abnormality of DNA repair (HP:0003254)2.77680887
34Narrow nasal bridge (HP:0000446)2.75171363
35Sclerocornea (HP:0000647)2.73263566
36Abnormality of serine family amino acid metabolism (HP:0010894)2.71359433
37Abnormality of glycine metabolism (HP:0010895)2.71359433
38Hypoplastic pelvis (HP:0008839)2.68754518
39Irregular epiphyses (HP:0010582)2.67101054
40Photophobia (HP:0000613)2.64650119
41Central scotoma (HP:0000603)2.64145338
42Optic nerve hypoplasia (HP:0000609)2.63479442
43Gingivitis (HP:0000230)2.63142572
44Abnormality of the fovea (HP:0000493)2.62004247
45Abdominal situs inversus (HP:0003363)2.60496791
46Abnormality of abdominal situs (HP:0011620)2.60496791
47Postaxial foot polydactyly (HP:0001830)2.59697496
48Maternal diabetes (HP:0009800)2.55153614
49Oligodactyly (hands) (HP:0001180)2.51300830
50Anencephaly (HP:0002323)2.50721988
51Abnormality of the renal medulla (HP:0100957)2.50687828
52Abnormal respiratory motile cilium morphology (HP:0005938)2.50079355
53Abnormal respiratory epithelium morphology (HP:0012253)2.50079355
54Epileptic encephalopathy (HP:0200134)2.49482245
55Cystic liver disease (HP:0006706)2.48828150
56Failure to thrive in infancy (HP:0001531)2.48503434
57Poor coordination (HP:0002370)2.46337850
58Bifid tongue (HP:0010297)2.45889573
59Type II diabetes mellitus (HP:0005978)2.45798543
60Retinitis pigmentosa (HP:0000510)2.44622718
61Aplasia/Hypoplasia of the lens (HP:0008063)2.43510044
62Acute necrotizing encephalopathy (HP:0006965)2.42152529
63Abnormality of the septum pellucidum (HP:0007375)2.40887562
64Hyperglycinuria (HP:0003108)2.37085382
65Holoprosencephaly (HP:0001360)2.34438926
66Anophthalmia (HP:0000528)2.33683677
67Vaginal atresia (HP:0000148)2.33226403
68Oligodactyly (HP:0012165)2.31279254
69Hepatoblastoma (HP:0002884)2.31080351
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.29691007
71Abnormality of the phalanges of the 5th finger (HP:0004213)2.26954975
72Increased IgM level (HP:0003496)2.26169607
73* Male pseudohermaphroditism (HP:0000037)2.24031867
74Pendular nystagmus (HP:0012043)2.23264608
75Aplasia/Hypoplasia of the spleen (HP:0010451)2.22595145
76Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.22402689
77Short middle phalanx of the 5th finger (HP:0004220)2.21644971
78Asplenia (HP:0001746)2.20203878
79Esotropia (HP:0000565)2.19541681
80Acute encephalopathy (HP:0006846)2.19512795
81Abnormal ciliary motility (HP:0012262)2.18599480
82Postaxial hand polydactyly (HP:0001162)2.17523651
83Progressive cerebellar ataxia (HP:0002073)2.16212280
84Occipital encephalocele (HP:0002085)2.14561968
85Genital tract atresia (HP:0001827)2.12552036
86Thyroid-stimulating hormone excess (HP:0002925)2.12272045
87Aplasia/Hypoplasia of the macula (HP:0008059)2.09913947
88Increased hepatocellular lipid droplets (HP:0006565)2.09594943
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.08909183
90Abnormal lung lobation (HP:0002101)2.08205564
91Methylmalonic acidemia (HP:0002912)2.08171576
92Eczematoid dermatitis (HP:0000976)2.08131333
93Chorioretinal atrophy (HP:0000533)2.06410984
94Aplasia/Hypoplasia of the fibula (HP:0006492)2.05739783
95Atelectasis (HP:0100750)2.05567723
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03502634
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.03245139
98Growth hormone deficiency (HP:0000824)2.00755177
99Depressed nasal ridge (HP:0000457)2.00374585
100Dry hair (HP:0011359)2.00359320
101Vitreoretinal degeneration (HP:0000655)2.00012288
102Congenital stationary night blindness (HP:0007642)15.6119005
103Amaurosis fugax (HP:0100576)1.99113151
104Fibular hypoplasia (HP:0003038)1.97293101
105Recurrent abscess formation (HP:0002722)1.97049024
106Flat cornea (HP:0007720)1.97040919
107Abnormal mitochondria in muscle tissue (HP:0008316)1.95088755
108Macular degeneration (HP:0000608)1.94085373
109Choroideremia (HP:0001139)1.93244250
110Increased CSF lactate (HP:0002490)1.93032465
111Congenital malformation of the right heart (HP:0011723)1.92977315
112Double outlet right ventricle (HP:0001719)1.92977315
113Median cleft lip (HP:0000161)1.91246837
114Rib fusion (HP:0000902)1.91150655
115Congenital hepatic fibrosis (HP:0002612)1.91070655
116Preaxial hand polydactyly (HP:0001177)1.90379474
117Aplasia/Hypoplasia of the breasts (HP:0010311)1.89989166
118Specific learning disability (HP:0001328)1.88390449
119Osteomalacia (HP:0002749)1.88323368
120Hypoplastic ischia (HP:0003175)1.88007087
121Breast aplasia (HP:0100783)1.87996090
122Abnormal hair whorl (HP:0010721)1.86308287
123* True hermaphroditism (HP:0010459)1.86168260
124Progressive macrocephaly (HP:0004481)1.85512912
125High anterior hairline (HP:0009890)1.85462491
126Abolished electroretinogram (ERG) (HP:0000550)1.85365077
127Gonadotropin excess (HP:0000837)1.85336041
128Chronic hepatic failure (HP:0100626)1.84465204
129Mitochondrial inheritance (HP:0001427)1.82896243
130Vertebral compression fractures (HP:0002953)1.82891406
131Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.82451164
132* Gonadal dysgenesis (HP:0000133)1.78767521
133Aplasia/hypoplasia of the uterus (HP:0008684)1.78658907
134Abnormality of molar (HP:0011077)1.77870775
135Abnormality of molar morphology (HP:0011070)1.77870775
136Hypoplasia of the uterus (HP:0000013)1.77576155
137Dandy-Walker malformation (HP:0001305)1.76860539
138Basal ganglia calcification (HP:0002135)1.76739877
139Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76643699
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.76573282
141Long nose (HP:0003189)1.76449491
142Narrow forehead (HP:0000341)1.76213825
143Abnormality of the middle phalanges of the toes (HP:0010183)1.76131669
144Abnormality of the labia minora (HP:0012880)1.75687189
145Absent/shortened dynein arms (HP:0200106)1.74953886
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.74953886
147Aganglionic megacolon (HP:0002251)1.74796425
148Cerebellar dysplasia (HP:0007033)1.73939997
149Meckel diverticulum (HP:0002245)1.73615106
150Erectile abnormalities (HP:0100639)1.73104104
151Abnormal respiratory motile cilium physiology (HP:0012261)1.72858224
152Abnormality of serum amino acid levels (HP:0003112)1.71864907
153Abnormality of the dental root (HP:0006486)1.71457070
154Taurodontia (HP:0000679)1.71457070
155Abnormality of permanent molar morphology (HP:0011071)1.71457070
156Reticulocytopenia (HP:0001896)1.70846532
157Hematochezia (HP:0002573)1.70785843
158Decreased testicular size (HP:0008734)1.70356960
159Focal motor seizures (HP:0011153)1.70223447
160Recurrent gram-negative bacterial infections (HP:0005420)1.69987152
161Lipid accumulation in hepatocytes (HP:0006561)1.69192896
162Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68178473
163Premature loss of primary teeth (HP:0006323)1.67240724
164Severe visual impairment (HP:0001141)1.66637628
165Progressive visual loss (HP:0000529)1.65867764
166Congenital sensorineural hearing impairment (HP:0008527)1.64715245
167Synostosis involving the elbow (HP:0003938)1.64650356
168Humeroradial synostosis (HP:0003041)1.64650356
169Recurrent bacterial skin infections (HP:0005406)1.64140795
170Abnormality of macrophages (HP:0004311)1.63765901
171Abnormality of the columella (HP:0009929)1.61540461
172Broad foot (HP:0001769)1.60582411
173Pancreatic cysts (HP:0001737)1.59166812
174Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.58056751
175Urethral obstruction (HP:0000796)1.57927976
176Periodontitis (HP:0000704)1.54661799
177Hip dysplasia (HP:0001385)1.54299173
178Hydroxyprolinuria (HP:0003080)1.54170410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA35.71304026
2PBK4.93905655
3CDK194.30659617
4SIK34.29110758
5MKNK13.38887792
6IRAK23.37322327
7EPHB23.17734384
8BLK2.96960116
9TRIM282.88979497
10BRSK22.82266378
11CASK2.75661465
12MKNK22.74378750
13IRAK42.45092493
14BRD42.42436852
15VRK22.38753904
16DYRK32.37741375
17INSRR2.37578053
18BCR2.26501476
19STK162.24137720
20WEE12.00998515
21KSR12.00871897
22IRAK12.00826478
23CDC71.96149915
24PAK61.94883357
25MAP4K21.92170381
26CAMKK21.87887075
27MAP3K141.83567842
28PLK21.78361393
29NEK61.78153219
30MARK11.76482281
31SRPK11.72566399
32ERBB21.67146922
33EPHA41.61816913
34MAP3K131.61086708
35CAMK1D1.60344054
36VRK11.56713767
37PRPF4B1.54877218
38NUAK11.50618454
39RIPK11.49453418
40IRAK31.49408372
41PNCK1.47105997
42DYRK1B1.47001185
43CCNB11.46421853
44PLK31.45513645
45CSNK1G11.40675440
46GRK11.40447473
47BRSK11.40006111
48PLK41.36460900
49TTK1.35489771
50RIPK41.31198633
51NTRK21.28765144
52MAPK131.28454505
53CSNK1G31.25616366
54CSNK1G21.19230471
55EIF2AK21.17942865
56NEK11.15447691
57BCKDK1.15009115
58PHKG21.12541047
59PHKG11.12541047
60ZAK1.11189443
61SGK4941.08042348
62SGK2231.08042348
63FRK1.05763197
64MAPK71.03904477
65PLK11.03008017
66RPS6KA41.01501323
67PINK11.00456529
68TGFBR10.97505574
69PRKCZ0.97380544
70TBK10.96496181
71TXK0.95575959
72PRKCE0.95085380
73CSNK1A1L0.94626211
74NEK90.93844485
75ERBB30.93176993
76DYRK1A0.92633588
77BUB10.92069717
78IKBKE0.91194942
79PAK30.88584071
80NLK0.86078414
81SIK10.83467028
82AURKB0.80810687
83MAPK150.79832595
84ADRBK20.77065849
85RPS6KB20.76250013
86PKN10.74338499
87BMPR1B0.73429531
88KIT0.73187087
89AKT30.72184256
90NTRK30.71728250
91PRKCD0.68778926
92PRKCG0.68562045
93MAP3K40.64576616
94UHMK10.64518569
95PASK0.64452550
96CAMK1G0.63654359
97MINK10.60743130
98MAP2K60.59921141
99IKBKB0.58298331
100CSNK1A10.57995396
101SGK20.56472636
102STK30.54586878
103NTRK10.53972208
104PIK3CA0.53358640
105CHUK0.52855061
106ADRBK10.52590909
107ERN10.51961283
108FER0.51363081
109CAMK2A0.51349556
110WNK30.49144984
111MAP3K100.45934494
112ACVR1B0.45681854
113ATR0.45588931
114CDK180.45336194
115CHEK20.44493025
116PRKD30.44473430
117FGFR10.44069851
118NME10.43984748
119ATM0.42868891
120BMPR20.42623929
121MST40.41970902
122TAOK20.40758264
123ICK0.40723411
124STK110.39427874
125DYRK20.39327890
126SYK0.39124349
127CAMK2D0.39105370
128PRKCA0.38885206
129CSNK2A10.37993641
130MAPK120.37232564
131CDK30.36187800
132CAMK10.35403934
133RPS6KA20.34832421
134* PRKACA0.34111408
135TAF10.33851287
136YES10.33420258
137MAPK90.32164446
138NEK20.31554132
139PRKAA20.30845076
140SGK10.29984589
141CSNK2A20.29907330
142PRKAA10.29736784
143CDK11A0.29180328
144FLT30.28450488
145MAPK100.28309159
146ROCK10.27442729
147PRKACB0.26674914
148PRKACG0.26593893
149WNK40.26029085
150CDK150.25771746
151MAP2K70.25705175
152ROCK20.25350999
153MAP3K120.24436622
154MARK20.24062922
155TNK20.23944502
156CDK140.23623528
157CDK70.23622913
158CSNK1E0.23582365
159CDK50.22573084
160CAMKK10.22513070
161STK38L0.22307899
162TNIK0.20128484
163BMX0.19931682
164AKT10.19890025
165LYN0.18628380
166RPS6KA50.18545219

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.47088633
2Nicotine addiction_Homo sapiens_hsa050333.94702749
3Protein export_Homo sapiens_hsa030603.15448765
4Synaptic vesicle cycle_Homo sapiens_hsa047212.86333625
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71236712
6Graft-versus-host disease_Homo sapiens_hsa053322.68072308
7Propanoate metabolism_Homo sapiens_hsa006402.67001440
8Steroid biosynthesis_Homo sapiens_hsa001002.49561393
9Mismatch repair_Homo sapiens_hsa034302.42812619
10Oxidative phosphorylation_Homo sapiens_hsa001902.40329780
11Allograft rejection_Homo sapiens_hsa053302.38735768
12Ribosome_Homo sapiens_hsa030102.37883270
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21135415
14Type I diabetes mellitus_Homo sapiens_hsa049402.21002665
15Morphine addiction_Homo sapiens_hsa050322.17932770
16Rheumatoid arthritis_Homo sapiens_hsa053232.14465393
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06838829
18Parkinsons disease_Homo sapiens_hsa050122.05225334
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04883429
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.04665350
21GABAergic synapse_Homo sapiens_hsa047272.04070414
22Fanconi anemia pathway_Homo sapiens_hsa034601.99580031
23Collecting duct acid secretion_Homo sapiens_hsa049661.94924107
24Olfactory transduction_Homo sapiens_hsa047401.92319954
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82567945
26Homologous recombination_Homo sapiens_hsa034401.81656038
27Fatty acid elongation_Homo sapiens_hsa000621.81517856
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79177330
29Spliceosome_Homo sapiens_hsa030401.77797902
30Staphylococcus aureus infection_Homo sapiens_hsa051501.76632399
31Butanoate metabolism_Homo sapiens_hsa006501.70997866
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69712575
33Autoimmune thyroid disease_Homo sapiens_hsa053201.68972314
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67081881
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.65779008
36Hedgehog signaling pathway_Homo sapiens_hsa043401.64769155
37DNA replication_Homo sapiens_hsa030301.63761585
38Huntingtons disease_Homo sapiens_hsa050161.57213199
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56261826
40One carbon pool by folate_Homo sapiens_hsa006701.52488379
41Circadian rhythm_Homo sapiens_hsa047101.50937697
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.48013451
43Circadian entrainment_Homo sapiens_hsa047131.44897004
44Non-homologous end-joining_Homo sapiens_hsa034501.43994525
45Nucleotide excision repair_Homo sapiens_hsa034201.42303033
46Basal transcription factors_Homo sapiens_hsa030221.40938944
47Peroxisome_Homo sapiens_hsa041461.40234636
48Sphingolipid metabolism_Homo sapiens_hsa006001.38829520
49Base excision repair_Homo sapiens_hsa034101.35779975
50Glutathione metabolism_Homo sapiens_hsa004801.35465771
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34046035
52Axon guidance_Homo sapiens_hsa043601.33346520
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29383265
54Vitamin digestion and absorption_Homo sapiens_hsa049771.28563296
55Taste transduction_Homo sapiens_hsa047421.28470722
56Retinol metabolism_Homo sapiens_hsa008301.26833901
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.26070086
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24195339
59Nitrogen metabolism_Homo sapiens_hsa009101.24036068
60Alzheimers disease_Homo sapiens_hsa050101.20506018
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.18102897
62Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15040230
63RNA polymerase_Homo sapiens_hsa030201.14769302
64Tryptophan metabolism_Homo sapiens_hsa003801.13133559
65RNA degradation_Homo sapiens_hsa030181.11569026
66Pyruvate metabolism_Homo sapiens_hsa006201.08874061
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05874234
68Phagosome_Homo sapiens_hsa041451.05626932
69Legionellosis_Homo sapiens_hsa051341.05274470
70beta-Alanine metabolism_Homo sapiens_hsa004101.03932437
71Hippo signaling pathway_Homo sapiens_hsa043901.02581521
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00450119
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94911930
74Glutamatergic synapse_Homo sapiens_hsa047240.90782265
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90707773
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88797291
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87861625
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87192334
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86997948
80Wnt signaling pathway_Homo sapiens_hsa043100.86640682
81Serotonergic synapse_Homo sapiens_hsa047260.86631838
82Notch signaling pathway_Homo sapiens_hsa043300.86134119
83Regulation of autophagy_Homo sapiens_hsa041400.85591438
84TNF signaling pathway_Homo sapiens_hsa046680.84910006
85Cholinergic synapse_Homo sapiens_hsa047250.84434434
86Carbon metabolism_Homo sapiens_hsa012000.83992959
87Chemokine signaling pathway_Homo sapiens_hsa040620.83776168
88Chemical carcinogenesis_Homo sapiens_hsa052040.83588704
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83128216
90RNA transport_Homo sapiens_hsa030130.82318718
91African trypanosomiasis_Homo sapiens_hsa051430.82042722
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81619400
93Metabolic pathways_Homo sapiens_hsa011000.81442608
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81282797
95Melanogenesis_Homo sapiens_hsa049160.80336568
96Calcium signaling pathway_Homo sapiens_hsa040200.79773970
97Fatty acid metabolism_Homo sapiens_hsa012120.79495107
98Fatty acid degradation_Homo sapiens_hsa000710.77500865
99Sulfur relay system_Homo sapiens_hsa041220.77061609
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.76932678
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75258728
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.74900918
103Lysosome_Homo sapiens_hsa041420.73564322
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73139403
105Malaria_Homo sapiens_hsa051440.72043705
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71423927
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70879637
108Inositol phosphate metabolism_Homo sapiens_hsa005620.70001308
109Leishmaniasis_Homo sapiens_hsa051400.67607701
110p53 signaling pathway_Homo sapiens_hsa041150.67137713
111Ether lipid metabolism_Homo sapiens_hsa005650.65626751
112Purine metabolism_Homo sapiens_hsa002300.65518448
113Salivary secretion_Homo sapiens_hsa049700.65458089
114TGF-beta signaling pathway_Homo sapiens_hsa043500.65174272
115Asthma_Homo sapiens_hsa053100.65142220
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64534582
117Salmonella infection_Homo sapiens_hsa051320.63794793
118Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63579823
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62046519
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62006161
121Type II diabetes mellitus_Homo sapiens_hsa049300.61023743
122Fructose and mannose metabolism_Homo sapiens_hsa000510.60079293
123Cell cycle_Homo sapiens_hsa041100.59978294
124Dopaminergic synapse_Homo sapiens_hsa047280.59839258
125Fat digestion and absorption_Homo sapiens_hsa049750.59544667
126Tyrosine metabolism_Homo sapiens_hsa003500.59154011
127Arginine and proline metabolism_Homo sapiens_hsa003300.58903169
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58347610
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58338527
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57058818
131Herpes simplex infection_Homo sapiens_hsa051680.55617435
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54888788
133Biosynthesis of amino acids_Homo sapiens_hsa012300.54877226
134Basal cell carcinoma_Homo sapiens_hsa052170.54416366
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53853430
136Insulin secretion_Homo sapiens_hsa049110.53181246
137N-Glycan biosynthesis_Homo sapiens_hsa005100.52329232
138Pyrimidine metabolism_Homo sapiens_hsa002400.50150824
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47691789
140Vibrio cholerae infection_Homo sapiens_hsa051100.47044217
141Apoptosis_Homo sapiens_hsa042100.46077532
142Mineral absorption_Homo sapiens_hsa049780.45641640
143Linoleic acid metabolism_Homo sapiens_hsa005910.45625411
144Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45083627
145Tuberculosis_Homo sapiens_hsa051520.44615888
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44346629
147cAMP signaling pathway_Homo sapiens_hsa040240.44109886
148Phenylalanine metabolism_Homo sapiens_hsa003600.43128278
149Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42740321
150Folate biosynthesis_Homo sapiens_hsa007900.42372725
151Histidine metabolism_Homo sapiens_hsa003400.42020214
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41173780
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40714470
154Proteasome_Homo sapiens_hsa030500.38544030
155Influenza A_Homo sapiens_hsa051640.36857978
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35829965
157Sphingolipid signaling pathway_Homo sapiens_hsa040710.34146847
158Starch and sucrose metabolism_Homo sapiens_hsa005000.33940541
159ErbB signaling pathway_Homo sapiens_hsa040120.33750208
160Thyroid hormone synthesis_Homo sapiens_hsa049180.33662279
161Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33448067
162Oxytocin signaling pathway_Homo sapiens_hsa049210.30534145
163Dilated cardiomyopathy_Homo sapiens_hsa054140.30533031
164Cocaine addiction_Homo sapiens_hsa050300.29386955
165Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28139200
166Complement and coagulation cascades_Homo sapiens_hsa046100.26951798
167Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.26545021
168Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26331367
169Arachidonic acid metabolism_Homo sapiens_hsa005900.26318154
170Cardiac muscle contraction_Homo sapiens_hsa042600.26028112
171Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25795839
172Prion diseases_Homo sapiens_hsa050200.23470901
173Hematopoietic cell lineage_Homo sapiens_hsa046400.21586806
174cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20582879
175Pertussis_Homo sapiens_hsa051330.20404782
176Steroid hormone biosynthesis_Homo sapiens_hsa001400.20281340
177Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.20126085
178Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19674800
179Measles_Homo sapiens_hsa051620.19656950
180Central carbon metabolism in cancer_Homo sapiens_hsa052300.18533697
181HTLV-I infection_Homo sapiens_hsa051660.17243690
182Alcoholism_Homo sapiens_hsa050340.17116753

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