SS18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.44268102
2DNA unwinding involved in DNA replication (GO:0006268)4.06772773
3maturation of SSU-rRNA (GO:0030490)4.00057519
4DNA strand elongation involved in DNA replication (GO:0006271)3.99206908
5mitotic sister chromatid cohesion (GO:0007064)3.87742296
6DNA strand elongation (GO:0022616)3.79084158
7pre-miRNA processing (GO:0031054)3.78998529
8telomere maintenance via semi-conservative replication (GO:0032201)3.71269232
9viral transcription (GO:0019083)3.70316384
10DNA replication initiation (GO:0006270)3.70007159
11establishment of integrated proviral latency (GO:0075713)3.69558300
12translational termination (GO:0006415)3.63133837
13protein localization to kinetochore (GO:0034501)3.54055324
14mitotic spindle checkpoint (GO:0071174)3.47749008
15regulation of centriole replication (GO:0046599)3.41165695
16telomere maintenance via recombination (GO:0000722)3.35709408
17formation of translation preinitiation complex (GO:0001731)3.35544185
18regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.30267988
19regulation of mitotic metaphase/anaphase transition (GO:0030071)3.30267988
20mitotic recombination (GO:0006312)3.28911626
21non-recombinational repair (GO:0000726)3.28264818
22double-strand break repair via nonhomologous end joining (GO:0006303)3.28264818
23negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26509287
24positive regulation of mitotic sister chromatid separation (GO:1901970)3.24573746
25positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.24573746
26positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.24573746
27mitotic metaphase plate congression (GO:0007080)3.21655108
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20731603
29translational elongation (GO:0006414)3.19386288
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18710257
31regulation of mitotic sister chromatid segregation (GO:0033047)3.18216597
32regulation of sister chromatid segregation (GO:0033045)3.18216597
33regulation of mitotic sister chromatid separation (GO:0010965)3.18216597
34UDP-N-acetylglucosamine metabolic process (GO:0006047)3.16173685
35DNA topological change (GO:0006265)3.14284744
36mitotic nuclear envelope disassembly (GO:0007077)3.13187011
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11190824
38translational initiation (GO:0006413)3.10518892
39ribosomal small subunit biogenesis (GO:0042274)3.09942725
40mitotic spindle assembly checkpoint (GO:0007094)3.08244573
41regulation of spindle organization (GO:0090224)3.08079435
42DNA replication-dependent nucleosome assembly (GO:0006335)3.05423296
43DNA replication-dependent nucleosome organization (GO:0034723)3.05423296
44ribosomal large subunit biogenesis (GO:0042273)3.05208367
45spindle assembly checkpoint (GO:0071173)3.05029684
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04029875
47negative regulation of DNA recombination (GO:0045910)3.01066829
48metaphase plate congression (GO:0051310)3.00907579
49DNA ligation (GO:0006266)3.00320781
50nuclear pore organization (GO:0006999)3.00314755
51COPII vesicle coating (GO:0048208)2.99473500
52nucleotide-excision repair, DNA gap filling (GO:0006297)2.98869246
53telomere maintenance via telomere lengthening (GO:0010833)2.98641480
54DNA double-strand break processing (GO:0000729)2.97678364
55protein localization to chromosome, centromeric region (GO:0071459)2.96337339
56cotranslational protein targeting to membrane (GO:0006613)2.96024290
57protein targeting to ER (GO:0045047)2.95154000
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91088781
59regulation of centrosome duplication (GO:0010824)2.89841854
60nucleobase biosynthetic process (GO:0046112)2.89558196
61DNA replication checkpoint (GO:0000076)2.89203517
62nuclear pore complex assembly (GO:0051292)2.87142468
63CENP-A containing nucleosome assembly (GO:0034080)2.86577010
64membrane disassembly (GO:0030397)2.86075124
65nuclear envelope disassembly (GO:0051081)2.86075124
66mitotic chromosome condensation (GO:0007076)2.85346270
67establishment of viral latency (GO:0019043)2.84900303
68viral life cycle (GO:0019058)2.84434653
69establishment of protein localization to endoplasmic reticulum (GO:0072599)2.81340276
70IMP biosynthetic process (GO:0006188)2.80362916
71L-serine metabolic process (GO:0006563)2.79280817
72ribosome assembly (GO:0042255)2.78811826
73kinetochore organization (GO:0051383)2.77832268
74ATP-dependent chromatin remodeling (GO:0043044)2.77452167
75regulation of centrosome cycle (GO:0046605)2.76846734
76chromatin remodeling at centromere (GO:0031055)2.76678552
77ribonucleoprotein complex biogenesis (GO:0022613)2.75481481
78regulation of transforming growth factor beta2 production (GO:0032909)2.75248152
79cell fate commitment involved in formation of primary germ layer (GO:0060795)2.74805238
80attachment of spindle microtubules to kinetochore (GO:0008608)2.73934172
81DNA replication-independent nucleosome organization (GO:0034724)2.73282562
82DNA replication-independent nucleosome assembly (GO:0006336)2.73282562
83protein localization to endoplasmic reticulum (GO:0070972)2.73282131
84establishment of chromosome localization (GO:0051303)2.72150079
85intra-S DNA damage checkpoint (GO:0031573)2.71551028
86positive regulation of chromosome segregation (GO:0051984)2.71297340
87cellular protein complex disassembly (GO:0043624)2.71070150
88spindle assembly involved in mitosis (GO:0090307)2.68359390
89response to X-ray (GO:0010165)2.68311940
90somatic recombination of immunoglobulin gene segments (GO:0016447)2.65411080
91IMP metabolic process (GO:0046040)2.64242668
92histone H2A acetylation (GO:0043968)2.63811365
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.63604130
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63604130
95DNA duplex unwinding (GO:0032508)2.62226460
96negative regulation of DNA repair (GO:0045738)2.61941522
97regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61908969
98regulation of mitotic spindle checkpoint (GO:1903504)2.61908969
99tRNA aminoacylation for protein translation (GO:0006418)2.60187680
100intraciliary transport (GO:0042073)2.60118175
101DNA geometric change (GO:0032392)2.59714262
102mismatch repair (GO:0006298)2.59268200
103purine nucleobase biosynthetic process (GO:0009113)2.58573627
104microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.57469031
105somatic cell DNA recombination (GO:0016444)2.56987287
106somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.56987287
107positive regulation of SMAD protein import into nucleus (GO:0060391)2.55868240
108ribosome biogenesis (GO:0042254)2.55339100
109nuclear-transcribed mRNA catabolic process (GO:0000956)2.54400333
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54364547
111amino acid activation (GO:0043038)2.53962317
112tRNA aminoacylation (GO:0043039)2.53962317
113regulation of mitotic spindle organization (GO:0060236)2.52650706
114somatic diversification of immunoglobulins (GO:0016445)2.52036624
115negative regulation of RNA splicing (GO:0033119)2.51719286
116folic acid-containing compound biosynthetic process (GO:0009396)2.50895770
117paraxial mesoderm development (GO:0048339)2.50183741
118protein complex disassembly (GO:0043241)2.48983120
119somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48562430
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48562430
121isotype switching (GO:0045190)2.48562430
122axonemal dynein complex assembly (GO:0070286)2.48166139
123somatic diversification of immune receptors (GO:0002200)2.48029940
124telomere maintenance (GO:0000723)2.47760543
125mitotic G2/M transition checkpoint (GO:0044818)2.47503218
126telomere organization (GO:0032200)2.47328317
127epithelial cilium movement (GO:0003351)2.45020302
128rRNA processing (GO:0006364)2.45015116
129transcription-coupled nucleotide-excision repair (GO:0006283)2.44185525
130mRNA catabolic process (GO:0006402)2.43697039
131RNA catabolic process (GO:0006401)2.39303447
132regulation of chromosome segregation (GO:0051983)2.38648049
133meiotic chromosome segregation (GO:0045132)2.38609585
134rRNA metabolic process (GO:0016072)2.35097498
135regulation of helicase activity (GO:0051095)2.35081775
136spindle checkpoint (GO:0031577)2.34574460
137histone exchange (GO:0043486)2.33501635
138kinetochore assembly (GO:0051382)2.32530831
139nuclear envelope organization (GO:0006998)2.32470998
140mitotic sister chromatid segregation (GO:0000070)2.31519476
141negative regulation of chromosome segregation (GO:0051985)2.29673022
142regulation of sister chromatid cohesion (GO:0007063)2.29587358
143sister chromatid segregation (GO:0000819)2.29556080
144regulation of histone H3-K9 methylation (GO:0051570)2.28146876
145negative regulation of mRNA processing (GO:0050686)2.28059449
146protein K6-linked ubiquitination (GO:0085020)2.27892104
147RNA splicing, via transesterification reactions (GO:0000375)2.27767588
148macromolecular complex disassembly (GO:0032984)2.27637390
149negative regulation of mitotic sister chromatid separation (GO:2000816)2.27615044
150negative regulation of mitotic sister chromatid segregation (GO:0033048)2.27615044
151negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.27615044
152negative regulation of sister chromatid segregation (GO:0033046)2.27615044
153pore complex assembly (GO:0046931)2.27284709
154mRNA splicing, via spliceosome (GO:0000398)2.26923502
155RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.26923502
156postreplication repair (GO:0006301)2.26600476

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.01343512
2* FOXM1_23109430_ChIP-Seq_U2OS_Human3.82827074
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.56750594
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42478557
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.11646931
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93701276
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90699115
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.61587438
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.55529973
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36407615
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.27479533
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.20350685
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20043547
14AR_21909140_ChIP-Seq_LNCAP_Human2.19095661
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17581573
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16998483
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14138424
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05731511
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04076969
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.03657769
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.03432477
22XRN2_22483619_ChIP-Seq_HELA_Human2.01805695
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.95505227
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92110307
25MYC_22102868_ChIP-Seq_BL_Human1.90938790
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86291436
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85978492
28VDR_23849224_ChIP-Seq_CD4+_Human1.84713420
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80339673
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.75533621
31EWS_26573619_Chip-Seq_HEK293_Human1.74105810
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.74011047
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73055070
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72617075
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70874651
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68585126
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68060844
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66871533
39FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63992687
40ELK1_19687146_ChIP-ChIP_HELA_Human1.63321624
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63166875
42FOXP3_21729870_ChIP-Seq_TREG_Human1.59190087
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54771327
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.54044340
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53680135
46DCP1A_22483619_ChIP-Seq_HELA_Human1.53298813
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52449946
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.51305745
49ZNF274_21170338_ChIP-Seq_K562_Hela1.48561932
50* TTF2_22483619_ChIP-Seq_HELA_Human1.46747183
51FUS_26573619_Chip-Seq_HEK293_Human1.46339567
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44778137
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44069673
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42388750
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41519092
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.40562206
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40153871
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.39654082
59GABP_19822575_ChIP-Seq_HepG2_Human1.37385413
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36840459
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.36759918
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34120686
63* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32647751
64CIITA_25753668_ChIP-Seq_RAJI_Human1.32551593
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32076248
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31016242
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30337088
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29336547
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29336547
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29336547
71MYC_18940864_ChIP-ChIP_HL60_Human1.27288793
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26948245
73SPI1_23547873_ChIP-Seq_NB4_Human1.26928212
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25298759
75VDR_21846776_ChIP-Seq_THP-1_Human1.25067768
76KDM5A_27292631_Chip-Seq_BREAST_Human1.24637141
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23660704
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22915243
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22553653
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20638298
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20382142
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.19908343
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.19730217
84* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19627280
85IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.19281904
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19019966
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18629290
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18451048
89* BRD4_25478319_ChIP-Seq_HGPS_Human1.15829959
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15623569
91IRF1_19129219_ChIP-ChIP_H3396_Human1.14763803
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13951692
93SOX17_20123909_ChIP-Seq_XEN_Mouse1.13694303
94TAF15_26573619_Chip-Seq_HEK293_Human1.12832368
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11753321
96TFEB_21752829_ChIP-Seq_HELA_Human1.09885207
97MYB_26560356_Chip-Seq_TH2_Human1.09397165
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09144421
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08679815
100IGF1R_20145208_ChIP-Seq_DFB_Human1.07895118
101TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06641047
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06424561
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06059374
104MAF_26560356_Chip-Seq_TH1_Human1.05780103
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05215075
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05183126
107MYB_26560356_Chip-Seq_TH1_Human1.04635314
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04615823
109MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03612400
110SCL_19346495_ChIP-Seq_HPC-7_Human1.03178371
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01337809
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01032336
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00944706
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00840405
115EZH2_27294783_Chip-Seq_NPCs_Mouse1.00530129
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00109981
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.99564877
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99381163
119* P300_19829295_ChIP-Seq_ESCs_Human0.98476317
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.98193537
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95661259
122UTX_26944678_Chip-Seq_JUKART_Human0.94861917
123POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94694334
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93926412
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.93886412
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93653324
127SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92809842
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92354989
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91973237
130NFE2_27457419_Chip-Seq_LIVER_Mouse0.91821159
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.91642111
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91359889
133ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91202489
134SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90850248
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90296560
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89761443
137SALL1_21062744_ChIP-ChIP_HESCs_Human0.89695568
138STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89453331
139PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89173724
140VDR_22108803_ChIP-Seq_LS180_Human0.87708832
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87421672
142* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87048622
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86701078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.22735196
2MP0010094_abnormal_chromosome_stability2.88482423
3MP0008057_abnormal_DNA_replication2.79328072
4MP0004957_abnormal_blastocyst_morpholog2.76059231
5MP0003077_abnormal_cell_cycle2.68339332
6MP0003111_abnormal_nucleus_morphology2.62848982
7MP0002396_abnormal_hematopoietic_system2.39250955
8MP0008789_abnormal_olfactory_epithelium2.26473293
9MP0009697_abnormal_copulation2.25942216
10MP0010352_gastrointestinal_tract_polyps2.25590903
11MP0008007_abnormal_cellular_replicative2.25499596
12MP0003890_abnormal_embryonic-extraembry2.19152372
13MP0008058_abnormal_DNA_repair1.98978831
14MP0002009_preneoplasia1.96021079
15MP0003763_abnormal_thymus_physiology1.91016609
16MP0008877_abnormal_DNA_methylation1.90057285
17MP0005257_abnormal_intraocular_pressure1.84807056
18MP0008932_abnormal_embryonic_tissue1.76879342
19MP0000647_abnormal_sebaceous_gland1.73950941
20MP0002233_abnormal_nose_morphology1.72802995
21MP0005248_abnormal_Harderian_gland1.66300188
22MP0005394_taste/olfaction_phenotype1.64332345
23MP0005499_abnormal_olfactory_system1.64332345
24MP0000350_abnormal_cell_proliferation1.57474666
25MP0009333_abnormal_splenocyte_physiolog1.56202192
26MP0006054_spinal_hemorrhage1.55509012
27MP0006072_abnormal_retinal_apoptosis1.53051020
28* MP0001730_embryonic_growth_arrest1.52104293
29MP0000490_abnormal_crypts_of1.51588267
30MP0002697_abnormal_eye_size1.47784163
31MP0001299_abnormal_eye_distance/1.43311282
32MP0004808_abnormal_hematopoietic_stem1.42400439
33MP0002254_reproductive_system_inflammat1.42295412
34MP0010030_abnormal_orbit_morphology1.42091133
35MP0005275_abnormal_skin_tensile1.41641644
36MP0001286_abnormal_eye_development1.40641528
37MP0003567_abnormal_fetal_cardiomyocyte1.34870736
38MP0010234_abnormal_vibrissa_follicle1.34057177
39MP0005023_abnormal_wound_healing1.33835910
40MP0001697_abnormal_embryo_size1.31011447
41* MP0001672_abnormal_embryogenesis/_devel1.29756856
42* MP0005380_embryogenesis_phenotype1.29756856
43MP0003950_abnormal_plasma_membrane1.28449344
44MP0003566_abnormal_cell_adhesion1.27621478
45MP0001293_anophthalmia1.24654437
46MP0001661_extended_life_span1.24352232
47MP0002398_abnormal_bone_marrow1.23882349
48MP0000383_abnormal_hair_follicle1.21899951
49MP0005671_abnormal_response_to1.21467688
50MP0002019_abnormal_tumor_incidence1.21456072
51MP0010307_abnormal_tumor_latency1.20289594
52MP0000465_gastrointestinal_hemorrhage1.19112905
53* MP0003984_embryonic_growth_retardation1.18953417
54* MP0002088_abnormal_embryonic_growth/wei1.17999724
55MP0000685_abnormal_immune_system1.17848283
56MP0000703_abnormal_thymus_morphology1.17407154
57MP0004133_heterotaxia1.16174722
58* MP0002085_abnormal_embryonic_tissue1.15817341
59MP0003705_abnormal_hypodermis_morpholog1.15374868
60MP0002722_abnormal_immune_system1.14663404
61MP0003755_abnormal_palate_morphology1.14610653
62MP0009703_decreased_birth_body1.12564411
63MP0000689_abnormal_spleen_morphology1.11623315
64MP0008438_abnormal_cutaneous_collagen1.11106951
65* MP0002086_abnormal_extraembryonic_tissu1.11011417
66* MP0002080_prenatal_lethality1.10777812
67MP0001835_abnormal_antigen_presentation1.10764055
68MP0004147_increased_porphyrin_level1.10231654
69MP0000432_abnormal_head_morphology1.09260849
70MP0003786_premature_aging1.08346827
71MP0005397_hematopoietic_system_phenotyp1.08011814
72MP0001545_abnormal_hematopoietic_system1.08011814
73MP0005075_abnormal_melanosome_morpholog1.07345853
74MP0002102_abnormal_ear_morphology1.06603364
75MP0000537_abnormal_urethra_morphology1.06527719
76MP0004197_abnormal_fetal_growth/weight/1.06450484
77MP0006292_abnormal_olfactory_placode1.06310755
78* MP0002084_abnormal_developmental_patter1.05189302
79MP0001800_abnormal_humoral_immune1.03237348
80MP0002132_abnormal_respiratory_system1.01955604
81MP0000427_abnormal_hair_cycle1.01591002
82MP0003453_abnormal_keratinocyte_physiol1.01557949
83MP0000313_abnormal_cell_death1.00476738
84MP0009278_abnormal_bone_marrow1.00212635
85MP0003119_abnormal_digestive_system0.99860771
86MP0002420_abnormal_adaptive_immunity0.97923899
87MP0009053_abnormal_anal_canal0.97694169
88MP0000716_abnormal_immune_system0.97275603
89MP0002405_respiratory_system_inflammati0.96536264
90MP0002429_abnormal_blood_cell0.96491073
91MP0002452_abnormal_antigen_presenting0.95775000
92MP0001819_abnormal_immune_cell0.95758600
93MP0005395_other_phenotype0.95234070
94MP0003941_abnormal_skin_development0.94965798
95MP0003937_abnormal_limbs/digits/tail_de0.94659612
96MP0002060_abnormal_skin_morphology0.94611346
97MP0010368_abnormal_lymphatic_system0.94122337
98MP0002098_abnormal_vibrissa_morphology0.93783871
99MP0005391_vision/eye_phenotype0.93338723
100MP0000858_altered_metastatic_potential0.92820036
101MP0010678_abnormal_skin_adnexa0.91231896
102MP0000358_abnormal_cell_content/0.90225671
103MP0001984_abnormal_olfaction0.90058129
104MP0005076_abnormal_cell_differentiation0.90020955
105MP0002166_altered_tumor_susceptibility0.89162823
106MP0000377_abnormal_hair_follicle0.88888231
107MP0003935_abnormal_craniofacial_develop0.87648100
108MP0005171_absent_coat_pigmentation0.87157968
109MP0010155_abnormal_intestine_physiology0.87105944
110MP0002723_abnormal_immune_serum0.86481868
111MP0001243_abnormal_dermal_layer0.86467514
112MP0001915_intracranial_hemorrhage0.85923127
113MP0003385_abnormal_body_wall0.85742945
114MP0003718_maternal_effect0.85450233
115MP0001879_abnormal_lymphatic_vessel0.84759178
116MP0000733_abnormal_muscle_development0.84677215
117MP0001849_ear_inflammation0.84530605
118MP0003806_abnormal_nucleotide_metabolis0.84033341
119MP0005408_hypopigmentation0.83790106
120MP0005503_abnormal_tendon_morphology0.83446104
121MP0002933_joint_inflammation0.82151483
122MP0002163_abnormal_gland_morphology0.81925796
123MP0003221_abnormal_cardiomyocyte_apopto0.81906063
124MP0003123_paternal_imprinting0.81355566
125MP0003448_altered_tumor_morphology0.80972605
126MP0005253_abnormal_eye_physiology0.80546642
127MP0000762_abnormal_tongue_morphology0.80531077
128MP0002751_abnormal_autonomic_nervous0.79714203
129MP0002111_abnormal_tail_morphology0.79588343
130MP0002092_abnormal_eye_morphology0.79527675
131MP0001216_abnormal_epidermal_layer0.79138119
132MP0002938_white_spotting0.78852035
133MP0001853_heart_inflammation0.78648527
134MP0009672_abnormal_birth_weight0.78437313
135MP0000428_abnormal_craniofacial_morphol0.77439400
136MP0000477_abnormal_intestine_morphology0.77357678
137MP0002877_abnormal_melanocyte_morpholog0.75705933
138MP0005025_abnormal_response_to0.75320993
139MP0005000_abnormal_immune_tolerance0.75003704
140MP0003943_abnormal_hepatobiliary_system0.74378159
141MP0002210_abnormal_sex_determination0.74093451
142MP0001929_abnormal_gametogenesis0.73870047
143MP0002006_tumorigenesis0.73430876
144MP0004272_abnormal_basement_membrane0.72918778
145MP0003828_pulmonary_edema0.72776924
146MP0004947_skin_inflammation0.72767077
147MP0002109_abnormal_limb_morphology0.72109642
148MP0005501_abnormal_skin_physiology0.72005134
149MP0009384_cardiac_valve_regurgitation0.71297633
150MP0003279_aneurysm0.71199852

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)3.36673547
2Reticulocytopenia (HP:0001896)3.35600672
3Abnormality of cells of the erythroid lineage (HP:0012130)3.03031182
4Selective tooth agenesis (HP:0001592)2.96356141
5Cortical dysplasia (HP:0002539)2.92358876
6Shoulder girdle muscle weakness (HP:0003547)2.74926255
7Abnormal number of erythroid precursors (HP:0012131)2.72793073
8Birth length less than 3rd percentile (HP:0003561)2.70954814
9Medulloblastoma (HP:0002885)2.64966772
10Breast hypoplasia (HP:0003187)2.62438927
11Abnormality of the hip-girdle musculature (HP:0001445)2.62251754
12Abnormality of the musculature of the pelvis (HP:0001469)2.62251754
13Thrombocytosis (HP:0001894)2.58627922
14Biliary tract neoplasm (HP:0100574)2.48976389
15Congenital primary aphakia (HP:0007707)2.48572919
16Aplastic anemia (HP:0001915)2.44837794
17Nephroblastoma (Wilms tumor) (HP:0002667)2.35091940
18Chronic otitis media (HP:0000389)2.34444541
19Short 4th metacarpal (HP:0010044)2.33172356
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33172356
21Medial flaring of the eyebrow (HP:0010747)2.31665932
22Chronic hepatic failure (HP:0100626)2.31319673
23Abnormality of the anterior horn cell (HP:0006802)2.31044377
24Degeneration of anterior horn cells (HP:0002398)2.31044377
25Pelvic girdle muscle weakness (HP:0003749)2.30891675
26Rhinitis (HP:0012384)2.29322135
27Embryonal renal neoplasm (HP:0011794)2.26331036
28True hermaphroditism (HP:0010459)2.25974604
29Abnormal respiratory epithelium morphology (HP:0012253)2.23284874
30Abnormal respiratory motile cilium morphology (HP:0005938)2.23284874
31Papillary thyroid carcinoma (HP:0002895)2.20510762
32Neoplasm of the small intestine (HP:0100833)2.18881593
33IgM deficiency (HP:0002850)2.15874805
34Nephrogenic diabetes insipidus (HP:0009806)2.14717388
35Stenosis of the external auditory canal (HP:0000402)2.14368847
36Chromsome breakage (HP:0040012)2.12844694
37Abnormality of the astrocytes (HP:0100707)2.12321346
38Astrocytoma (HP:0009592)2.12321346
39Patellar aplasia (HP:0006443)2.08865105
40Oral leukoplakia (HP:0002745)2.08136296
41Abnormal hair whorl (HP:0010721)2.07765959
42Vaginal atresia (HP:0000148)2.07101113
43Macrocytic anemia (HP:0001972)2.06980117
44Glioma (HP:0009733)2.06360340
45Gait imbalance (HP:0002141)2.05994833
46Ependymoma (HP:0002888)2.04805278
47Basal cell carcinoma (HP:0002671)2.03876961
48Neoplasm of the oral cavity (HP:0100649)2.02740597
49Neoplasm of striated muscle (HP:0009728)2.02733523
50Broad foot (HP:0001769)2.02689309
51Ankle contracture (HP:0006466)2.02618524
52Meckel diverticulum (HP:0002245)2.01483147
53Breast carcinoma (HP:0003002)2.00797501
54Myelodysplasia (HP:0002863)2.00675178
55Deep philtrum (HP:0002002)1.99861559
56Aplasia/Hypoplasia of the patella (HP:0006498)1.99406631
57Rough bone trabeculation (HP:0100670)1.99139610
58Pancreatic fibrosis (HP:0100732)1.98871127
59Deviation of the thumb (HP:0009603)1.97699852
60Genital tract atresia (HP:0001827)1.97450526
61Absent radius (HP:0003974)1.96585811
62Sloping forehead (HP:0000340)1.95961671
63Proximal placement of thumb (HP:0009623)1.95525791
64Thyroid carcinoma (HP:0002890)1.94881619
65Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93952249
66Poor coordination (HP:0002370)1.92154984
67Ovarian neoplasm (HP:0100615)1.92084867
68Abnormality of the ileum (HP:0001549)1.92028606
69Pancreatic cysts (HP:0001737)1.92003769
70Trismus (HP:0000211)1.91666148
71Chronic bronchitis (HP:0004469)1.90967599
72Abnormality of the umbilical cord (HP:0010881)1.90294930
73Abnormal number of incisors (HP:0011064)1.90222851
74Malignant gastrointestinal tract tumors (HP:0006749)1.89471097
75Gastrointestinal carcinoma (HP:0002672)1.89471097
76Abnormality of chromosome stability (HP:0003220)1.89468973
77Absent thumb (HP:0009777)1.88673086
78Abnormal biliary tract morphology (HP:0012440)1.88503806
79Elevated erythrocyte sedimentation rate (HP:0003565)1.87951089
80Premature graying of hair (HP:0002216)1.87617719
81Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87439960
82Neoplasm of the pancreas (HP:0002894)1.86742681
83Protrusio acetabuli (HP:0003179)1.86611670
84Abnormality of the preputium (HP:0100587)1.85639972
85Lymphoma (HP:0002665)1.85443194
86Amaurosis fugax (HP:0100576)1.85438902
87Abnormality of the duodenum (HP:0002246)1.84322218
88Agnosia (HP:0010524)1.84271208
89Asplenia (HP:0001746)1.83898652
90Premature rupture of membranes (HP:0001788)1.83372030
91Abnormal umbilical cord blood vessels (HP:0011403)1.83342132
92Single umbilical artery (HP:0001195)1.83342132
93Abnormality of the fetal cardiovascular system (HP:0010948)1.83342132
94Abnormal respiratory motile cilium physiology (HP:0012261)1.83128007
95Pallor (HP:0000980)1.82115944
96Neoplasm of the rectum (HP:0100743)1.80757122
97Uterine neoplasm (HP:0010784)1.80036492
98Aplasia involving forearm bones (HP:0009822)1.79158677
99Absent forearm bone (HP:0003953)1.79158677
100T lymphocytopenia (HP:0005403)1.78635803
101Decreased testicular size (HP:0008734)1.78553350
102Atresia of the external auditory canal (HP:0000413)1.78376240
103Ectopic kidney (HP:0000086)1.77928679
104Abnormal ciliary motility (HP:0012262)1.77506945
105Abnormality of the labia minora (HP:0012880)1.76606381
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75229193
107Adrenal hypoplasia (HP:0000835)1.75013007
108Abnormal lung lobation (HP:0002101)1.74654488
109Dandy-Walker malformation (HP:0001305)1.74557948
110Spastic diplegia (HP:0001264)1.74225744
111Broad face (HP:0000283)1.74139952
112Acute myeloid leukemia (HP:0004808)1.73692286
113Abnormality of the parietal bone (HP:0002696)1.72932103
114Supernumerary spleens (HP:0009799)1.72356612
115Supernumerary bones of the axial skeleton (HP:0009144)1.71698288
116Abnormality of the calcaneus (HP:0008364)1.71659458
117Curly hair (HP:0002212)1.69920773
118Small intestinal stenosis (HP:0012848)1.69461450
119Duodenal stenosis (HP:0100867)1.69461450
120Abnormality of midbrain morphology (HP:0002418)1.68773371
121Molar tooth sign on MRI (HP:0002419)1.68773371
122Median cleft lip (HP:0000161)1.68544735
123Bile duct proliferation (HP:0001408)1.68396887
124Abnormal biliary tract physiology (HP:0012439)1.68396887
125Facial cleft (HP:0002006)1.68035134
126Abnormality of T cells (HP:0002843)1.67988798
127Sparse lateral eyebrow (HP:0005338)1.67729579
128Aplasia/Hypoplasia of the spleen (HP:0010451)1.67512215
129Triphalangeal thumb (HP:0001199)1.67471324
13011 pairs of ribs (HP:0000878)1.66979006
131Aplasia/hypoplasia of the humerus (HP:0006507)1.66968080
132High anterior hairline (HP:0009890)1.66599283
133Supernumerary ribs (HP:0005815)1.66571293
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.66480195
135Absent/shortened dynein arms (HP:0200106)1.66480195
136Neoplasm of the colon (HP:0100273)1.66357722
137Esophageal atresia (HP:0002032)1.65358955
138Rhabdomyosarcoma (HP:0002859)1.65163097
139Overlapping toe (HP:0001845)1.64635471
140Postaxial foot polydactyly (HP:0001830)1.64367042
141Abnormality of T cell number (HP:0011839)1.64232185
142Vertebral arch anomaly (HP:0008438)1.63870808
143Abnormality of the fingertips (HP:0001211)1.63312092
144Bifid tongue (HP:0010297)1.62799875
145Blepharitis (HP:0000498)1.62664829
146Abnormality of the 4th metacarpal (HP:0010012)1.61166064
147Volvulus (HP:0002580)1.60079219
148Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59965796
149Abnormal protein N-linked glycosylation (HP:0012347)1.59965796
150Abnormal protein glycosylation (HP:0012346)1.59965796
151Abnormal glycosylation (HP:0012345)1.59965796
152Bronchiectasis (HP:0002110)1.59919844
153Congenital, generalized hypertrichosis (HP:0004540)1.59501423
154Osteolytic defects of the hand bones (HP:0009699)1.59309949
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.59309949
156Type I transferrin isoform profile (HP:0003642)1.59225119
157Abnormality of dentin (HP:0010299)1.59126690
158Abnormality of the peritoneum (HP:0002585)1.58886125
159Barrel-shaped chest (HP:0001552)1.58666183
160Entropion (HP:0000621)1.58466893
161Squamous cell carcinoma (HP:0002860)1.58422134
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.58219807
163Transitional cell carcinoma of the bladder (HP:0006740)1.57344723
164Cerebral hypomyelination (HP:0006808)1.56647236
165Cervical subluxation (HP:0003308)1.56347533
166Shallow orbits (HP:0000586)1.56285065
167Hypoplastic labia majora (HP:0000059)1.55847196
168Bone marrow hypocellularity (HP:0005528)1.55172091
169Hypoplastic pelvis (HP:0008839)1.54374980
170Hematochezia (HP:0002573)1.54204545
171Ulnar bowing (HP:0003031)1.54141831
172Intestinal atresia (HP:0011100)1.54083055
173Bladder carcinoma (HP:0002862)1.53859379
174Bladder neoplasm (HP:0009725)1.53859379
175Carpal bone hypoplasia (HP:0001498)1.53364701
176Trigonocephaly (HP:0000243)1.52307336
177Abnormality of T cell physiology (HP:0011840)1.51920073
178Hypoplasia of the radius (HP:0002984)1.50978023
179Short thumb (HP:0009778)1.50804336

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.46222251
2WEE13.37190614
3BUB13.03464290
4CDC72.90744250
5BCR2.41090802
6STK102.32506260
7NEK22.12890029
8NME21.96090626
9RPS6KB21.93606439
10RPS6KA41.87439694
11MAP4K11.84394625
12MKNK11.82456078
13TSSK61.79955973
14ERBB31.76855799
15EIF2AK11.75706337
16NLK1.75466613
17TNIK1.75384993
18EPHA21.73099770
19TGFBR11.69184962
20BMPR1B1.68734517
21EEF2K1.68474690
22TTK1.66185096
23CDK71.58335793
24PASK1.56749418
25WNK31.49478649
26SRPK11.48538234
27KDR1.45107212
28TESK21.43958476
29PLK41.43218065
30LRRK21.43052796
31SIK31.41132901
32AURKB1.36659978
33DYRK31.33914760
34PLK11.33777095
35TAF11.32634671
36MST41.30108418
37STK38L1.29073162
38MAP3K81.29064571
39STK241.28295479
40STK41.24605472
41BRSK21.23261907
42VRK11.22676945
43CDK41.18821771
44NUAK11.18806899
45LATS11.18107221
46ATR1.15272742
47TGFBR21.14658759
48BTK1.14173865
49PAK41.10880355
50JAK31.09442155
51PDK21.08573846
52NEK11.07288536
53TLK11.06612429
54ACVR1B1.06539300
55PIM11.05936492
56ERBB41.05932953
57PLK21.04490580
58TXK1.02810315
59MKNK21.02352272
60IRAK41.00564777
61NEK91.00030488
62EIF2AK30.99570219
63FLT30.97534614
64CDK120.96334498
65KIT0.96258827
66PLK30.94282924
67ZAP700.93608746
68TEC0.92787318
69ITK0.88798147
70FER0.87913370
71CHEK20.87156928
72FRK0.87138401
73EPHB10.86245513
74CDK60.85008961
75MELK0.84888833
76PDGFRA0.84856049
77CSF1R0.84830048
78MAP2K30.82691496
79STK30.81962301
80ZAK0.81667691
81CLK10.79349523
82MAP3K30.76346589
83AURKA0.76212161
84CHEK10.75826092
85PKN20.75508430
86PIM20.75120722
87BRSK10.73645089
88IKBKB0.73266322
89MAP3K140.71261726
90MAP3K100.70390733
91AKT30.65539242
92TBK10.62912014
93TYK20.61669880
94RPS6KA50.61428269
95MET0.61205347
96CDK80.61188969
97ALK0.60951816
98NEK60.60511645
99IKBKE0.59356938
100ATM0.59197002
101SCYL20.58596278
102LCK0.58517583
103TRIB30.57775279
104CSK0.56917596
105YES10.56650170
106TTN0.55779318
107TRPM70.53477758
108STK390.52335434
109CDK20.52160878
110MAPKAPK30.51867018
111EIF2AK20.51786180
112CDK90.51053351
113CHUK0.50592665
114MAP3K40.49388454
115BMPR20.49270914
116MAPKAPK20.48811141
117PAK10.48651491
118PAK20.48260796
119TIE10.47577737
120CSNK1G10.46408221
121PBK0.46395947
122PTK20.45507580
123CDK10.44451899
124CSNK2A10.43815496
125STK160.43425752
126BRD40.42525885
127FGFR10.41411843
128MARK30.40241330
129CSNK2A20.38833085
130VRK20.38552560
131PDGFRB0.38264888
132PRKCE0.35336524
133EGFR0.34617118
134FGFR20.34537879
135CSNK1G20.33864257
136CSNK1A1L0.33382251
137PAK30.32614940
138PRKDC0.29579689
139MAP2K20.27311243
140PIK3CA0.27085130
141CDK30.26113433
142IRAK10.26096388

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.28450303
2Mismatch repair_Homo sapiens_hsa034303.55211625
3Ribosome_Homo sapiens_hsa030102.95423250
4Spliceosome_Homo sapiens_hsa030402.77542211
5Base excision repair_Homo sapiens_hsa034102.73832352
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.67425614
7Homologous recombination_Homo sapiens_hsa034402.48228108
8Nucleotide excision repair_Homo sapiens_hsa034202.44084120
9Cell cycle_Homo sapiens_hsa041102.38963759
10RNA polymerase_Homo sapiens_hsa030202.36423022
11RNA transport_Homo sapiens_hsa030132.35044845
12Proteasome_Homo sapiens_hsa030502.23458459
13One carbon pool by folate_Homo sapiens_hsa006701.87693546
14Propanoate metabolism_Homo sapiens_hsa006401.86318957
15Non-homologous end-joining_Homo sapiens_hsa034501.84331663
16Pyrimidine metabolism_Homo sapiens_hsa002401.75467961
17Steroid biosynthesis_Homo sapiens_hsa001001.73105275
18Fanconi anemia pathway_Homo sapiens_hsa034601.69587234
19p53 signaling pathway_Homo sapiens_hsa041151.68931341
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.64318533
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63631608
22Basal transcription factors_Homo sapiens_hsa030221.59525624
23Primary immunodeficiency_Homo sapiens_hsa053401.56343320
24RNA degradation_Homo sapiens_hsa030181.46645462
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44784231
26Antigen processing and presentation_Homo sapiens_hsa046121.44767527
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35632177
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33549066
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27985557
30Herpes simplex infection_Homo sapiens_hsa051681.25269825
31mRNA surveillance pathway_Homo sapiens_hsa030151.23739676
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17899852
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16150187
34Small cell lung cancer_Homo sapiens_hsa052221.14836876
35Viral carcinogenesis_Homo sapiens_hsa052031.14064658
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.08870022
37Fatty acid elongation_Homo sapiens_hsa000621.05913111
38HTLV-I infection_Homo sapiens_hsa051661.03984246
39Measles_Homo sapiens_hsa051621.02700755
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98083691
41Systemic lupus erythematosus_Homo sapiens_hsa053220.97762422
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95766411
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94615882
44Basal cell carcinoma_Homo sapiens_hsa052170.94352522
45MicroRNAs in cancer_Homo sapiens_hsa052060.94012320
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92033256
47* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91291867
48Folate biosynthesis_Homo sapiens_hsa007900.88923907
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86896654
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86034082
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.85630812
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85585614
53Shigellosis_Homo sapiens_hsa051310.83978916
54TGF-beta signaling pathway_Homo sapiens_hsa043500.83959760
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83864104
56Legionellosis_Homo sapiens_hsa051340.83737496
57Pyruvate metabolism_Homo sapiens_hsa006200.83185972
58Viral myocarditis_Homo sapiens_hsa054160.83177726
59Thyroid cancer_Homo sapiens_hsa052160.82119322
60Adherens junction_Homo sapiens_hsa045200.80993304
61Purine metabolism_Homo sapiens_hsa002300.80975320
62Hippo signaling pathway_Homo sapiens_hsa043900.79480521
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.78730438
64Lysine degradation_Homo sapiens_hsa003100.77473086
65Hematopoietic cell lineage_Homo sapiens_hsa046400.77414412
66Apoptosis_Homo sapiens_hsa042100.76380546
67Notch signaling pathway_Homo sapiens_hsa043300.75858991
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75856366
69Oocyte meiosis_Homo sapiens_hsa041140.74417246
70Wnt signaling pathway_Homo sapiens_hsa043100.72906231
71Hepatitis B_Homo sapiens_hsa051610.69989519
72Biosynthesis of amino acids_Homo sapiens_hsa012300.69817390
73Chronic myeloid leukemia_Homo sapiens_hsa052200.69165685
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65992247
75Sulfur relay system_Homo sapiens_hsa041220.64489610
76Sphingolipid metabolism_Homo sapiens_hsa006000.64348055
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.63313560
78Toxoplasmosis_Homo sapiens_hsa051450.63135504
79Acute myeloid leukemia_Homo sapiens_hsa052210.63099502
80Selenocompound metabolism_Homo sapiens_hsa004500.62916551
81Leishmaniasis_Homo sapiens_hsa051400.62805802
82ECM-receptor interaction_Homo sapiens_hsa045120.62797173
83Fatty acid metabolism_Homo sapiens_hsa012120.61186488
84T cell receptor signaling pathway_Homo sapiens_hsa046600.61024415
85N-Glycan biosynthesis_Homo sapiens_hsa005100.60753124
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59997425
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59077146
88Colorectal cancer_Homo sapiens_hsa052100.59012741
89Pathways in cancer_Homo sapiens_hsa052000.58947298
90Circadian rhythm_Homo sapiens_hsa047100.58212187
91Prostate cancer_Homo sapiens_hsa052150.56599012
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56080760
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55902812
94Carbon metabolism_Homo sapiens_hsa012000.55785488
95Pentose phosphate pathway_Homo sapiens_hsa000300.55356695
96beta-Alanine metabolism_Homo sapiens_hsa004100.54889082
97Allograft rejection_Homo sapiens_hsa053300.54565110
98Proteoglycans in cancer_Homo sapiens_hsa052050.52516716
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52383117
100Malaria_Homo sapiens_hsa051440.51834630
101Butanoate metabolism_Homo sapiens_hsa006500.50558093
102Protein export_Homo sapiens_hsa030600.50550739
103Hedgehog signaling pathway_Homo sapiens_hsa043400.50187537
104Pancreatic cancer_Homo sapiens_hsa052120.49999831
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49161086
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48320104
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48247300
108Influenza A_Homo sapiens_hsa051640.48109493
109B cell receptor signaling pathway_Homo sapiens_hsa046620.48046321
110Glutathione metabolism_Homo sapiens_hsa004800.46744298
111Focal adhesion_Homo sapiens_hsa045100.46730540
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45899967
113Graft-versus-host disease_Homo sapiens_hsa053320.45742779
114Autoimmune thyroid disease_Homo sapiens_hsa053200.44693214
115Peroxisome_Homo sapiens_hsa041460.44506090
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44259275
117Vitamin B6 metabolism_Homo sapiens_hsa007500.43857694
118Melanoma_Homo sapiens_hsa052180.43034660
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42006969
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.39980480
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38576662
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38413159
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.38281388
124Tight junction_Homo sapiens_hsa045300.37866046
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37063195
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35903869
127Platelet activation_Homo sapiens_hsa046110.35501782
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34482313
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34386029
130Arachidonic acid metabolism_Homo sapiens_hsa005900.33351906
131Protein digestion and absorption_Homo sapiens_hsa049740.33265201
132Other glycan degradation_Homo sapiens_hsa005110.32968666
133Osteoclast differentiation_Homo sapiens_hsa043800.32764702
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32645669
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30861508
136Dorso-ventral axis formation_Homo sapiens_hsa043200.28624206
137Fatty acid degradation_Homo sapiens_hsa000710.25895605
138Metabolic pathways_Homo sapiens_hsa011000.23560112
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22682990
140Inositol phosphate metabolism_Homo sapiens_hsa005620.20795740

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