SS18L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.64657956
2vocalization behavior (GO:0071625)5.52763561
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36339145
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16651168
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09892934
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95749058
7synaptic vesicle exocytosis (GO:0016079)4.88122796
8regulation of glutamate receptor signaling pathway (GO:1900449)4.77874588
9locomotory exploration behavior (GO:0035641)4.75110033
10regulation of synaptic vesicle exocytosis (GO:2000300)4.70591486
11synaptic vesicle maturation (GO:0016188)4.65249070
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.62374236
13protein localization to synapse (GO:0035418)4.55915478
14neuron recognition (GO:0008038)4.53672341
15dendritic spine morphogenesis (GO:0060997)4.43687914
16glutamate secretion (GO:0014047)4.38822910
17axonal fasciculation (GO:0007413)4.28555239
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24079033
19glutamate receptor signaling pathway (GO:0007215)4.23097735
20regulation of synaptic vesicle transport (GO:1902803)4.19215890
21exploration behavior (GO:0035640)4.13021232
22synaptic transmission, glutamatergic (GO:0035249)4.06751794
23layer formation in cerebral cortex (GO:0021819)4.00213079
24neurotransmitter secretion (GO:0007269)3.98210197
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.96143869
26postsynaptic membrane organization (GO:0001941)3.90638890
27response to pheromone (GO:0019236)3.89849948
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88104228
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.87610120
30presynaptic membrane assembly (GO:0097105)3.87479015
31neuron-neuron synaptic transmission (GO:0007270)3.83493812
32regulation of neuronal synaptic plasticity (GO:0048168)3.82711223
33pyrimidine nucleobase catabolic process (GO:0006208)3.80904085
34cell migration in hindbrain (GO:0021535)3.75027060
35dendrite morphogenesis (GO:0048813)3.72266020
36synaptic vesicle endocytosis (GO:0048488)3.72157331
37regulation of synapse structural plasticity (GO:0051823)3.72119869
38neuronal action potential propagation (GO:0019227)3.70933529
39proline transport (GO:0015824)3.67157713
40central nervous system projection neuron axonogenesis (GO:0021952)3.62111917
41presynaptic membrane organization (GO:0097090)3.55424350
42cerebellar Purkinje cell differentiation (GO:0021702)3.54566772
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53452132
44gamma-aminobutyric acid transport (GO:0015812)3.52549129
45establishment of mitochondrion localization (GO:0051654)3.51670340
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50132816
47long-term memory (GO:0007616)3.45932060
48neurotransmitter-gated ion channel clustering (GO:0072578)3.45601502
49regulation of postsynaptic membrane potential (GO:0060078)3.45000771
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.43747439
51mitochondrion transport along microtubule (GO:0047497)3.43747439
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.41328649
53positive regulation of membrane potential (GO:0045838)3.41097618
54limb bud formation (GO:0060174)3.40395139
55positive regulation of synapse assembly (GO:0051965)3.38260385
56synapse assembly (GO:0007416)3.36230919
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.34750549
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.29661274
59regulation of dendritic spine morphogenesis (GO:0061001)3.29560503
60neurotransmitter transport (GO:0006836)3.27227470
61positive regulation of synapse maturation (GO:0090129)3.26584474
62startle response (GO:0001964)3.25980971
63regulation of neurotransmitter secretion (GO:0046928)3.16002039
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.15489348
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15267179
66nucleobase catabolic process (GO:0046113)3.15085156
67spinal cord development (GO:0021510)3.14605245
68long-term synaptic potentiation (GO:0060291)3.14270553
69sympathetic nervous system development (GO:0048485)3.13799638
70transmission of nerve impulse (GO:0019226)3.13745207
71regulation of vesicle fusion (GO:0031338)3.09719980
72regulation of synaptic plasticity (GO:0048167)3.09546159
73mechanosensory behavior (GO:0007638)3.08991193
74innervation (GO:0060384)3.08739140
75dendritic spine organization (GO:0097061)3.07595900
76auditory behavior (GO:0031223)3.04794080
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.01714409
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.01348423
79behavioral fear response (GO:0001662)3.01043510
80behavioral defense response (GO:0002209)3.01043510
81positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00951737
82response to histamine (GO:0034776)3.00901038
83regulation of neurotransmitter levels (GO:0001505)3.00758191
84intraspecies interaction between organisms (GO:0051703)2.99780991
85social behavior (GO:0035176)2.99780991
86regulation of synapse assembly (GO:0051963)2.99193700
87membrane hyperpolarization (GO:0060081)2.98833120
88regulation of respiratory system process (GO:0044065)2.97607239
89* dendrite development (GO:0016358)2.97208177
90learning (GO:0007612)2.97201171
91cerebellar granule cell differentiation (GO:0021707)2.97199816
92membrane depolarization (GO:0051899)2.96581265
93synapse organization (GO:0050808)2.95284724
94positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94616408
95neuronal ion channel clustering (GO:0045161)2.94587393
96response to auditory stimulus (GO:0010996)2.93632361
97regulation of neurotransmitter transport (GO:0051588)2.89590483
98membrane depolarization during action potential (GO:0086010)2.87756157
99behavioral response to nicotine (GO:0035095)2.86019181
100cerebellum development (GO:0021549)2.83766690
101central nervous system neuron axonogenesis (GO:0021955)2.82810133
102activation of protein kinase A activity (GO:0034199)2.82397277
103organelle transport along microtubule (GO:0072384)2.81784295
104regulation of dendritic spine development (GO:0060998)2.80991524
105prepulse inhibition (GO:0060134)2.80986361
106axon extension (GO:0048675)2.78776243
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77581954
108establishment of synaptic vesicle localization (GO:0097480)2.77066483
109synaptic vesicle transport (GO:0048489)2.77066483
110cell differentiation in hindbrain (GO:0021533)2.64970231
111central nervous system myelination (GO:0022010)2.64764629
112axon ensheathment in central nervous system (GO:0032291)2.64764629
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60855332
114negative regulation of dendrite development (GO:2000171)2.60350929
115forebrain neuron differentiation (GO:0021879)2.58822154
116atrial cardiac muscle cell action potential (GO:0086014)2.58082726
117glycerophospholipid catabolic process (GO:0046475)2.57273953
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57140407
119cochlea development (GO:0090102)2.50795857
120embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50274079
121ketone body metabolic process (GO:1902224)2.50109263
122retinal ganglion cell axon guidance (GO:0031290)2.50104219
123cellular ketone body metabolic process (GO:0046950)2.48242876
124neuromuscular synaptic transmission (GO:0007274)2.48090811
125cerebral cortex radially oriented cell migration (GO:0021799)2.47749643
126dopaminergic neuron differentiation (GO:0071542)2.46937204
127positive regulation of dendritic spine development (GO:0060999)2.46886269
128hippocampus development (GO:0021766)2.46005657
129melanin biosynthetic process (GO:0042438)2.40279521
130negative regulation of axon extension (GO:0030517)2.39319578
131secondary metabolite biosynthetic process (GO:0044550)2.39036850
132cellular potassium ion homeostasis (GO:0030007)2.36607582
133regulation of respiratory gaseous exchange (GO:0043576)2.35311451
134C4-dicarboxylate transport (GO:0015740)2.31901073
135regulation of synapse maturation (GO:0090128)2.30456620
136midbrain development (GO:0030901)2.29739604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01942303
2GBX2_23144817_ChIP-Seq_PC3_Human3.71554589
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91884139
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88868329
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76049211
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.54938481
7REST_21632747_ChIP-Seq_MESCs_Mouse2.53884117
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45819002
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45819002
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44375540
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41805266
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40082855
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37103046
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32298137
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24543438
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23373372
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22615721
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21960485
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.18490396
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.13488450
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.10773023
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09878746
23DROSHA_22980978_ChIP-Seq_HELA_Human2.04849953
24AR_21572438_ChIP-Seq_LNCaP_Human2.03958419
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03786559
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.00291150
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.98413062
28TAF15_26573619_Chip-Seq_HEK293_Human1.92968854
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87157300
30IGF1R_20145208_ChIP-Seq_DFB_Human1.84962493
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84134735
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83939041
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81325364
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78191766
35SMAD4_21799915_ChIP-Seq_A2780_Human1.77487347
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65659228
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65315518
38P300_19829295_ChIP-Seq_ESCs_Human1.64048941
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.62077762
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.59975978
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59052000
42ZNF274_21170338_ChIP-Seq_K562_Hela1.58264610
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56925130
44RNF2_27304074_Chip-Seq_NSC_Mouse1.50158097
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.48647448
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47678065
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47622579
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42180484
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.42172181
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41290342
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39647192
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39074871
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38318021
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.37053198
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36433284
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35321798
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.34870681
58AR_25329375_ChIP-Seq_VCAP_Human1.34777010
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33819104
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33755037
61STAT3_23295773_ChIP-Seq_U87_Human1.33096125
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32189985
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30282576
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.29583810
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27691655
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.25794367
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24394091
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23262232
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.23111750
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22543570
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21840467
72AHR_22903824_ChIP-Seq_MCF-7_Human1.21522250
73AR_19668381_ChIP-Seq_PC3_Human1.20407288
74FUS_26573619_Chip-Seq_HEK293_Human1.19472340
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.18856458
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18179230
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17121769
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16478516
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16155049
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16155049
81TCF4_23295773_ChIP-Seq_U87_Human1.15438225
82* SOX9_26525672_Chip-Seq_HEART_Mouse1.15162993
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14318864
84RUNX2_22187159_ChIP-Seq_PCA_Human1.13724118
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11719584
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11605610
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.11420662
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10904864
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.10609987
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10356755
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.10047533
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09955243
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08115868
94ER_23166858_ChIP-Seq_MCF-7_Human1.07768873
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07712482
96VDR_22108803_ChIP-Seq_LS180_Human1.07300798
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.06647892
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05681781
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05144704
100ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03226184
101* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01802640
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01121595
103EWS_26573619_Chip-Seq_HEK293_Human1.00744743
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00454474
105JUN_21703547_ChIP-Seq_K562_Human0.98527783
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98002423
107BCAT_22108803_ChIP-Seq_LS180_Human0.97923061
108TP53_18474530_ChIP-ChIP_U2OS_Human0.97585296
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.97113591
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96802689
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94610291
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.93832437
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93683421
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92870152
115ISL1_27105846_Chip-Seq_CPCs_Mouse0.92673816
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91071107
117TP53_16413492_ChIP-PET_HCT116_Human0.90654430
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90337962
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90102391
120TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89099184
121POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88998534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.50878322
2MP0003880_abnormal_central_pattern4.96630803
3MP0003635_abnormal_synaptic_transmissio3.84387426
4MP0004270_analgesia3.53469836
5MP0005423_abnormal_somatic_nervous3.28317184
6MP0002063_abnormal_learning/memory/cond3.22513626
7MP0009745_abnormal_behavioral_response3.05308298
8MP0002064_seizures2.87525641
9MP0001968_abnormal_touch/_nociception2.82756063
10MP0002572_abnormal_emotion/affect_behav2.75511754
11MP0009046_muscle_twitch2.62930072
12MP0000778_abnormal_nervous_system2.60281378
13MP0002734_abnormal_mechanical_nocicepti2.58106140
14MP0006276_abnormal_autonomic_nervous2.53248308
15MP0001486_abnormal_startle_reflex2.48650360
16MP0003787_abnormal_imprinting2.33486309
17MP0000566_synostosis2.30210416
18MP0003136_yellow_coat_color2.27275088
19MP0002272_abnormal_nervous_system2.25830396
20MP0001501_abnormal_sleep_pattern2.16940539
21MP0005645_abnormal_hypothalamus_physiol2.16898492
22MP0002735_abnormal_chemical_nociception2.16756250
23MP0002736_abnormal_nociception_after2.15119360
24MP0002184_abnormal_innervation2.11722772
25MP0001440_abnormal_grooming_behavior2.06981397
26MP0003122_maternal_imprinting2.04041986
27MP0003123_paternal_imprinting2.03846019
28MP0002733_abnormal_thermal_nociception1.97093135
29MP0002557_abnormal_social/conspecific_i1.90784044
30MP0002067_abnormal_sensory_capabilities1.90422832
31MP0005646_abnormal_pituitary_gland1.90280284
32MP0001529_abnormal_vocalization1.89264206
33MP0004924_abnormal_behavior1.87039002
34MP0005386_behavior/neurological_phenoty1.87039002
35MP0001984_abnormal_olfaction1.81624673
36MP0001970_abnormal_pain_threshold1.81464652
37MP0000569_abnormal_digit_pigmentation1.76709303
38MP0004811_abnormal_neuron_physiology1.74714773
39MP0001502_abnormal_circadian_rhythm1.68881574
40MP0002909_abnormal_adrenal_gland1.62061583
41MP0000955_abnormal_spinal_cord1.55409630
42MP0008569_lethality_at_weaning1.54280636
43MP0000372_irregular_coat_pigmentation1.51483944
44MP0002882_abnormal_neuron_morphology1.48678975
45MP0002822_catalepsy1.47246956
46MP0001188_hyperpigmentation1.41200151
47* MP0002066_abnormal_motor_capabilities/c1.35557252
48MP0004885_abnormal_endolymph1.34708886
49MP0009379_abnormal_foot_pigmentation1.33898113
50MP0005171_absent_coat_pigmentation1.32834135
51MP0009780_abnormal_chondrocyte_physiolo1.31429225
52MP0003121_genomic_imprinting1.31160340
53MP0002234_abnormal_pharynx_morphology1.30047752
54MP0001905_abnormal_dopamine_level1.27329835
55MP0003329_amyloid_beta_deposits1.26960791
56MP0004742_abnormal_vestibular_system1.25756763
57MP0004858_abnormal_nervous_system1.25678817
58MP0003879_abnormal_hair_cell1.24160684
59* MP0002152_abnormal_brain_morphology1.23901003
60MP0000631_abnormal_neuroendocrine_gland1.23462778
61MP0003938_abnormal_ear_development1.21967233
62MP0004133_heterotaxia1.17497956
63MP0003942_abnormal_urinary_system1.17397772
64MP0005551_abnormal_eye_electrophysiolog1.17044246
65MP0004142_abnormal_muscle_tone1.15706597
66MP0000534_abnormal_ureter_morphology1.13808515
67MP0003119_abnormal_digestive_system1.12088804
68MP0006292_abnormal_olfactory_placode1.12075757
69MP0000537_abnormal_urethra_morphology1.10780987
70MP0002638_abnormal_pupillary_reflex1.10607388
71MP0002938_white_spotting1.08096430
72MP0003283_abnormal_digestive_organ1.05498942
73MP0000579_abnormal_nail_morphology1.02116048
74MP0001293_anophthalmia1.01222153
75MP0010386_abnormal_urinary_bladder1.00602510
76MP0005394_taste/olfaction_phenotype0.99369295
77MP0005499_abnormal_olfactory_system0.99369295
78MP0002249_abnormal_larynx_morphology0.98912929
79MP0006072_abnormal_retinal_apoptosis0.97920355
80MP0002069_abnormal_eating/drinking_beha0.96633894
81MP0003567_abnormal_fetal_cardiomyocyte0.96626959
82MP0001324_abnormal_eye_pigmentation0.94977797
83MP0008875_abnormal_xenobiotic_pharmacok0.94651788
84MP0002163_abnormal_gland_morphology0.93141635
85MP0002837_dystrophic_cardiac_calcinosis0.92504938
86MP0002752_abnormal_somatic_nervous0.91869744
87MP0003937_abnormal_limbs/digits/tail_de0.91388199
88MP0002876_abnormal_thyroid_physiology0.90769983
89MP0000015_abnormal_ear_pigmentation0.89769519
90MP0003861_abnormal_nervous_system0.89351867
91MP0003633_abnormal_nervous_system0.88927382
92MP0002102_abnormal_ear_morphology0.88189667
93MP0001963_abnormal_hearing_physiology0.87978332
94MP0005187_abnormal_penis_morphology0.87253976
95MP0001346_abnormal_lacrimal_gland0.86772640
96MP0002229_neurodegeneration0.85085128
97MP0003631_nervous_system_phenotype0.84632297
98MP0004085_abnormal_heartbeat0.84189188
99MP0002697_abnormal_eye_size0.82903253
100MP0000427_abnormal_hair_cycle0.82408151
101MP0002081_perinatal_lethality0.79252115
102MP0002095_abnormal_skin_pigmentation0.78830251
103MP0003878_abnormal_ear_physiology0.78616195
104MP0005377_hearing/vestibular/ear_phenot0.78616195
105MP0001286_abnormal_eye_development0.77821918
106MP0000049_abnormal_middle_ear0.76036366
107MP0001177_atelectasis0.74471143
108MP0009672_abnormal_birth_weight0.74399939
109MP0005174_abnormal_tail_pigmentation0.72484918
110MP0001299_abnormal_eye_distance/0.71497566
111MP0000751_myopathy0.71388537
112MP0003634_abnormal_glial_cell0.70422409
113MP0005253_abnormal_eye_physiology0.69789072
114MP0002751_abnormal_autonomic_nervous0.69722229
115MP0005379_endocrine/exocrine_gland_phen0.68748232
116MP0003632_abnormal_nervous_system0.67805902
117MP0008872_abnormal_physiological_respon0.66517239
118MP0005535_abnormal_body_temperature0.66086031
119MP0002090_abnormal_vision0.66025613
120MP0003137_abnormal_impulse_conducting0.65808393
121MP0001485_abnormal_pinna_reflex0.65027315
122MP0004145_abnormal_muscle_electrophysio0.64166998
123MP0000026_abnormal_inner_ear0.64020570
124MP0003890_abnormal_embryonic-extraembry0.61891522
125MP0008961_abnormal_basal_metabolism0.61229772
126MP0001943_abnormal_respiration0.59069858
127MP0004484_altered_response_of0.58750444
128MP0010770_preweaning_lethality0.57995517
129MP0002082_postnatal_lethality0.57995517
130MP0005409_darkened_coat_color0.57375253
131MP0010769_abnormal_survival0.57300512
132MP0008877_abnormal_DNA_methylation0.55290419
133MP0010768_mortality/aging0.54236999
134MP0008874_decreased_physiological_sensi0.53741587

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.57603891
2Focal seizures (HP:0007359)5.22514325
3Myokymia (HP:0002411)5.08663629
4Epileptic encephalopathy (HP:0200134)4.66082844
5Febrile seizures (HP:0002373)4.46766614
6Atonic seizures (HP:0010819)4.40859905
7Progressive cerebellar ataxia (HP:0002073)4.32166742
8Visual hallucinations (HP:0002367)4.08187729
9Absence seizures (HP:0002121)3.80549110
10Hyperventilation (HP:0002883)3.68125180
11Broad-based gait (HP:0002136)3.61739519
12Drooling (HP:0002307)3.46000313
13Excessive salivation (HP:0003781)3.46000313
14Supranuclear gaze palsy (HP:0000605)3.44673998
15Dialeptic seizures (HP:0011146)3.44275841
16Generalized tonic-clonic seizures (HP:0002069)3.34720965
17Mutism (HP:0002300)3.12798751
18Amblyopia (HP:0000646)3.00101002
19Polyphagia (HP:0002591)2.98950557
20Truncal ataxia (HP:0002078)2.96186026
21Poor eye contact (HP:0000817)2.93685918
22Action tremor (HP:0002345)2.93049332
23Ankle clonus (HP:0011448)2.91824345
24Limb dystonia (HP:0002451)2.87002685
25Genetic anticipation (HP:0003743)2.83239326
26Urinary bladder sphincter dysfunction (HP:0002839)2.82645048
27Gaze-evoked nystagmus (HP:0000640)2.81924511
28Impaired vibration sensation in the lower limbs (HP:0002166)2.75586241
29Abnormal eating behavior (HP:0100738)2.74405102
30Gait imbalance (HP:0002141)2.72255732
31Abnormality of the corticospinal tract (HP:0002492)2.65580250
32Abnormal social behavior (HP:0012433)2.63548608
33Impaired social interactions (HP:0000735)2.63548608
34Progressive inability to walk (HP:0002505)2.63058870
35Absent speech (HP:0001344)2.60297365
36Epileptiform EEG discharges (HP:0011182)2.59758599
37Status epilepticus (HP:0002133)2.58497603
38Protruding tongue (HP:0010808)2.58130718
39Fetal akinesia sequence (HP:0001989)2.52261404
40Blue irides (HP:0000635)2.49412011
41EEG with generalized epileptiform discharges (HP:0011198)2.48504196
42Hemiparesis (HP:0001269)2.48210410
43Agitation (HP:0000713)2.47286110
44Anxiety (HP:0000739)2.47072149
45Dysdiadochokinesis (HP:0002075)2.44592772
46Depression (HP:0000716)2.42932819
47Impaired smooth pursuit (HP:0007772)2.39295016
48Hypsarrhythmia (HP:0002521)2.35871718
49Termporal pattern (HP:0011008)2.34842555
50Insidious onset (HP:0003587)2.34842555
51Inappropriate behavior (HP:0000719)2.34730104
52Amyotrophic lateral sclerosis (HP:0007354)2.34256629
53Dysmetria (HP:0001310)2.32649251
54Postural instability (HP:0002172)2.32577586
55Urinary urgency (HP:0000012)2.32346596
56Abnormality of salivation (HP:0100755)2.32025016
57Stereotypic behavior (HP:0000733)2.28838365
58Spastic gait (HP:0002064)2.27430494
59Akinesia (HP:0002304)2.22778021
60Exotropia (HP:0000577)2.21957024
61Pheochromocytoma (HP:0002666)2.20608978
62Specific learning disability (HP:0001328)2.20240846
63Failure to thrive in infancy (HP:0001531)2.20240341
64Concave nail (HP:0001598)2.20092730
65Abnormality of binocular vision (HP:0011514)2.18305255
66Diplopia (HP:0000651)2.18305255
67Papilledema (HP:0001085)2.17986062
68Abnormality of ocular smooth pursuit (HP:0000617)2.15126430
69Patellar aplasia (HP:0006443)2.14871684
70Abnormal hair whorl (HP:0010721)2.13445659
71Hypoplasia of the brainstem (HP:0002365)2.09413057
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09413057
73Inability to walk (HP:0002540)2.09342848
74Torticollis (HP:0000473)2.08663136
75Aplasia involving bones of the extremities (HP:0009825)2.08608171
76Aplasia involving bones of the upper limbs (HP:0009823)2.08608171
77Aplasia of the phalanges of the hand (HP:0009802)2.08608171
78Morphological abnormality of the pyramidal tract (HP:0002062)2.08166520
79Congenital primary aphakia (HP:0007707)2.06629593
80Neurofibrillary tangles (HP:0002185)2.05014891
81Aplasia/Hypoplasia of the patella (HP:0006498)2.01835511
82Abnormality of the lower motor neuron (HP:0002366)2.00221019
83Cerebral inclusion bodies (HP:0100314)1.99825653
84Split foot (HP:0001839)1.99405014
85Nephrogenic diabetes insipidus (HP:0009806)1.98916296
86Hyperthyroidism (HP:0000836)1.97330577
87Type II lissencephaly (HP:0007260)1.96149175
88Oligodactyly (hands) (HP:0001180)1.96142194
89Abnormality of the aortic arch (HP:0012303)1.94744744
90Abnormality of the labia minora (HP:0012880)1.94044396
91Sleep apnea (HP:0010535)1.93557891
92Esotropia (HP:0000565)1.92241229
93Lower limb muscle weakness (HP:0007340)1.91970344
94Medial flaring of the eyebrow (HP:0010747)1.91454995
95Open mouth (HP:0000194)1.90876604
96Bradykinesia (HP:0002067)1.89065011
97Deep venous thrombosis (HP:0002625)1.87553059
98Focal dystonia (HP:0004373)1.87448913
99Generalized hypopigmentation of hair (HP:0011358)1.86751066
100Sporadic (HP:0003745)1.86370813
10111 pairs of ribs (HP:0000878)1.84801737
102Autism (HP:0000717)1.84211718
103Hypoventilation (HP:0002791)1.84161915
104Aqueductal stenosis (HP:0002410)1.82392447
105Neuroendocrine neoplasm (HP:0100634)1.81588200
106Bronchomalacia (HP:0002780)1.81170693
107Anophthalmia (HP:0000528)1.81146741
108Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79238330
109Degeneration of the lateral corticospinal tracts (HP:0002314)1.79238330
110Generalized myoclonic seizures (HP:0002123)1.78972937
111Diastasis recti (HP:0001540)1.78941328
112Genital tract atresia (HP:0001827)1.78860415
113Lissencephaly (HP:0001339)1.77644169
114Widely spaced teeth (HP:0000687)1.75827540
115Megalencephaly (HP:0001355)1.75582151
116Vaginal atresia (HP:0000148)1.73307037
117Papillary thyroid carcinoma (HP:0002895)1.71621495
118Shawl scrotum (HP:0000049)1.70706497
119Impaired vibratory sensation (HP:0002495)1.70229104
120Cerebellar dysplasia (HP:0007033)1.68916076
121Hyperglycinemia (HP:0002154)1.66547523
122Spastic tetraplegia (HP:0002510)1.65656332
123CNS hypomyelination (HP:0003429)1.65349554
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64738075
125Morphological abnormality of the middle ear (HP:0008609)1.64616382
126Esophageal atresia (HP:0002032)1.63122108
127Congenital stationary night blindness (HP:0007642)1.62215868
128Fair hair (HP:0002286)1.60848838
129Delayed CNS myelination (HP:0002188)1.59504240
130Gastroesophageal reflux (HP:0002020)1.57124505
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.55922996
132Pachygyria (HP:0001302)1.55179764
133Limb hypertonia (HP:0002509)1.55031360
134Astrocytoma (HP:0009592)1.54829963
135Abnormality of the astrocytes (HP:0100707)1.54829963
136Hypoplasia of the corpus callosum (HP:0002079)1.54159200
137Morphological abnormality of the inner ear (HP:0011390)1.52882645
138Renal dysplasia (HP:0000110)1.52587799
139Hepatoblastoma (HP:0002884)1.52181316
140Midline defect of the nose (HP:0004122)1.51706103
141Cutaneous syndactyly (HP:0012725)1.51455558
142Labial hypoplasia (HP:0000066)1.51298613
143Cutaneous finger syndactyly (HP:0010554)1.50644039
144Scrotal hypoplasia (HP:0000046)1.50565140
145Impulsivity (HP:0100710)1.50044014
146Thickened helices (HP:0000391)1.48228075
147Delayed myelination (HP:0012448)1.47569987
148Enlarged penis (HP:0000040)1.47229866
149Prolonged partial thromboplastin time (HP:0003645)1.46884967
150Obsessive-compulsive behavior (HP:0000722)1.46176745
151Absent eyebrow (HP:0002223)1.44687339
152Alacrima (HP:0000522)1.43117469
153Abnormality of hair growth rate (HP:0011363)1.42832433
154Slow-growing hair (HP:0002217)1.42832433

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.93319557
2NTRK34.03740504
3EPHA43.30350426
4MAP3K43.23247821
5MAP3K92.96052013
6MAP2K72.88425914
7NTRK22.80233659
8MINK12.49368295
9MAPK132.36592075
10CASK2.15225831
11DAPK22.09940833
12KSR12.06876891
13MAP2K41.94057276
14MAP3K121.88891403
15PAK61.87320388
16SIK21.80837450
17WEE11.55319096
18TNIK1.52145350
19SIK31.48700518
20BCR1.48491338
21PNCK1.47496762
22WNK41.44940173
23CDK51.42373667
24WNK31.38668853
25PLK21.36261492
26DYRK21.35696279
27KSR21.35100860
28EEF2K1.34600191
29PRPF4B1.32857431
30UHMK11.30208640
31RIPK41.19549829
32TLK11.18284817
33LATS21.17539260
34DYRK1A1.16394440
35NTRK11.14120695
36ERBB31.13572007
37CDK191.11714868
38TYRO31.09302787
39MKNK21.08764608
40PRKD31.06869386
41SGK2231.06191151
42SGK4941.06191151
43SGK21.03393723
44PRKCG1.03055223
45FRK1.02607986
46DAPK11.02051560
47CAMK2A1.00989987
48MAP3K61.00073502
49CAMKK10.97303223
50GRK50.95773924
51PHKG20.95609077
52PHKG10.95609077
53PAK30.95256896
54AKT30.95128711
55CSNK1G20.94568594
56FGFR20.92593720
57CAMK1D0.91506818
58BRD40.90709597
59MAP2K60.87390039
60CDK180.85115402
61SIK10.79987847
62CDK150.78213839
63MARK20.76986690
64FES0.76846714
65MAP3K20.76102605
66ICK0.75843088
67RET0.74636216
68CAMK2B0.74351114
69CDK140.73213079
70SGK10.73109154
71CDK11A0.72643546
72SGK30.71798610
73STK390.70448426
74BMPR20.70355612
75STK380.69697296
76PINK10.69310525
77STK110.69020618
78CSNK1E0.66971571
79TRIM280.64769542
80CAMK40.63532355
81CAMK1G0.63047479
82OXSR10.61184294
83PRKCH0.60451870
84FGFR10.58866052
85CAMKK20.57093231
86ADRBK20.55966180
87PRKCZ0.55617757
88ARAF0.55522994
89RAF10.54581677
90CAMK10.54018435
91RPS6KA20.53662398
92PRKCE0.53566912
93CAMK2D0.49964352
94CSNK1D0.49816139
95EPHB20.49676653
96PIK3CA0.48404538
97LATS10.48232765
98TAOK30.47671748
99CSNK1G30.47328867
100FER0.47095266
101RPS6KB10.47033839
102PKN10.45407708
103CDC42BPA0.44776657
104MAPKAPK50.43291827
105FYN0.42995288
106ERBB20.42805413
107GRK10.42514653
108NME10.42195130
109INSRR0.41904880
110RPS6KA30.41324203
111MAPK150.41284165
112MAP3K130.41078254
113PRKAA10.40654023
114CAMK2G0.40589037
115SRPK10.40433674
116MAPK80.40416719
117GSK3B0.40253626
118CDK30.39664771
119BRAF0.39377685
120CSNK1A1L0.38409143
121TAOK10.37547650
122MKNK10.36833248
123WNK10.36687512
124BRSK10.36656943
125TRIB30.36056344
126MAPK100.35601061
127PRKDC0.34807783
128PRKCB0.34747927
129BMPR1B0.33550711
130PRKACA0.33083597
131NEK60.32713638
132YES10.32614869
133MAPK120.31116646
134ERBB40.30723007
135PRKG10.29807676

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.01176488
2Synaptic vesicle cycle_Homo sapiens_hsa047213.03893513
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72423851
4GABAergic synapse_Homo sapiens_hsa047272.69095839
5Circadian entrainment_Homo sapiens_hsa047132.58893267
6Glutamatergic synapse_Homo sapiens_hsa047242.56517274
7Olfactory transduction_Homo sapiens_hsa047402.47628670
8Long-term potentiation_Homo sapiens_hsa047202.44801711
9Morphine addiction_Homo sapiens_hsa050322.44654351
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38117797
11Amphetamine addiction_Homo sapiens_hsa050312.33613989
12Dopaminergic synapse_Homo sapiens_hsa047282.19899135
13Serotonergic synapse_Homo sapiens_hsa047261.91651073
14Insulin secretion_Homo sapiens_hsa049111.90846209
15Taste transduction_Homo sapiens_hsa047421.89140253
16Cholinergic synapse_Homo sapiens_hsa047251.89110715
17Cocaine addiction_Homo sapiens_hsa050301.84166010
18Salivary secretion_Homo sapiens_hsa049701.76471409
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71282242
20Long-term depression_Homo sapiens_hsa047301.69403764
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68364151
22Butanoate metabolism_Homo sapiens_hsa006501.65035356
23Renin secretion_Homo sapiens_hsa049241.64300076
24Axon guidance_Homo sapiens_hsa043601.64016623
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60122130
26Oxytocin signaling pathway_Homo sapiens_hsa049211.54746621
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.53848687
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50689438
29Gastric acid secretion_Homo sapiens_hsa049711.46977883
30Calcium signaling pathway_Homo sapiens_hsa040201.39964430
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39927559
32Collecting duct acid secretion_Homo sapiens_hsa049661.36926098
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34357892
34GnRH signaling pathway_Homo sapiens_hsa049121.33700394
35ErbB signaling pathway_Homo sapiens_hsa040121.29997322
36Gap junction_Homo sapiens_hsa045401.28237579
37Phototransduction_Homo sapiens_hsa047441.26825891
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26783003
39Type II diabetes mellitus_Homo sapiens_hsa049301.26409478
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24461851
41Caffeine metabolism_Homo sapiens_hsa002321.23003251
42Bile secretion_Homo sapiens_hsa049761.22333888
43Linoleic acid metabolism_Homo sapiens_hsa005911.21939032
44cAMP signaling pathway_Homo sapiens_hsa040241.21759050
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17672007
46Estrogen signaling pathway_Homo sapiens_hsa049151.09135754
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08810915
48Glioma_Homo sapiens_hsa052141.07041650
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04203832
50Steroid biosynthesis_Homo sapiens_hsa001001.02437844
51Vibrio cholerae infection_Homo sapiens_hsa051100.99640057
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97958644
53Melanogenesis_Homo sapiens_hsa049160.95253858
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95115585
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.92460719
56Basal cell carcinoma_Homo sapiens_hsa052170.91885804
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90397033
58Dorso-ventral axis formation_Homo sapiens_hsa043200.90139789
59Fatty acid biosynthesis_Homo sapiens_hsa000610.88316267
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86632119
61Choline metabolism in cancer_Homo sapiens_hsa052310.85154586
62MAPK signaling pathway_Homo sapiens_hsa040100.84237054
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84135240
64Hippo signaling pathway_Homo sapiens_hsa043900.82862253
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81483574
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.81445140
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81371548
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80575412
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80229423
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.79369711
71Endometrial cancer_Homo sapiens_hsa052130.78100435
72Hedgehog signaling pathway_Homo sapiens_hsa043400.76793938
73Circadian rhythm_Homo sapiens_hsa047100.76361935
74Oocyte meiosis_Homo sapiens_hsa041140.75242797
75Type I diabetes mellitus_Homo sapiens_hsa049400.73772622
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.73552088
77Cardiac muscle contraction_Homo sapiens_hsa042600.73508886
78Histidine metabolism_Homo sapiens_hsa003400.72978365
79Arginine biosynthesis_Homo sapiens_hsa002200.72664452
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72363325
81Colorectal cancer_Homo sapiens_hsa052100.71827869
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.71782174
83Tyrosine metabolism_Homo sapiens_hsa003500.71656377
84Renal cell carcinoma_Homo sapiens_hsa052110.70472677
85Ras signaling pathway_Homo sapiens_hsa040140.69916993
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69776935
87Retinol metabolism_Homo sapiens_hsa008300.69227811
88Wnt signaling pathway_Homo sapiens_hsa043100.68912693
89Non-small cell lung cancer_Homo sapiens_hsa052230.68441221
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68406764
91Dilated cardiomyopathy_Homo sapiens_hsa054140.66577039
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.64592677
93ABC transporters_Homo sapiens_hsa020100.63074515
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61499628
95Tryptophan metabolism_Homo sapiens_hsa003800.60521072
96Alcoholism_Homo sapiens_hsa050340.59421181
97Lysine degradation_Homo sapiens_hsa003100.59407246
98Ether lipid metabolism_Homo sapiens_hsa005650.58439060
99Thyroid hormone synthesis_Homo sapiens_hsa049180.57964702
100Vitamin B6 metabolism_Homo sapiens_hsa007500.57685227
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57535370
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57386331
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57026501
104Phenylalanine metabolism_Homo sapiens_hsa003600.56211335
105mTOR signaling pathway_Homo sapiens_hsa041500.55805441
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55107745
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54684918
108AMPK signaling pathway_Homo sapiens_hsa041520.54338491
109Propanoate metabolism_Homo sapiens_hsa006400.53118736
110Pancreatic secretion_Homo sapiens_hsa049720.53051460
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52529850
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52247171
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52162151
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51627226
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.50404202
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49112666
117VEGF signaling pathway_Homo sapiens_hsa043700.48942908
118Inositol phosphate metabolism_Homo sapiens_hsa005620.48177121
119Prion diseases_Homo sapiens_hsa050200.47876629
120Rap1 signaling pathway_Homo sapiens_hsa040150.47656445
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47642224
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47533906
123mRNA surveillance pathway_Homo sapiens_hsa030150.45980479
124Fanconi anemia pathway_Homo sapiens_hsa034600.45834553
125Glucagon signaling pathway_Homo sapiens_hsa049220.44751849
126Insulin signaling pathway_Homo sapiens_hsa049100.44506323
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43636371
128Ovarian steroidogenesis_Homo sapiens_hsa049130.43585317
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42659950
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42546531
131African trypanosomiasis_Homo sapiens_hsa051430.38375657
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37948041
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37628516
134Endocytosis_Homo sapiens_hsa041440.35963439
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35862723
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34941582
137Prolactin signaling pathway_Homo sapiens_hsa049170.33611072
138Chemokine signaling pathway_Homo sapiens_hsa040620.33534874
139T cell receptor signaling pathway_Homo sapiens_hsa046600.29258360

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