SSB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.58302957
2DNA unwinding involved in DNA replication (GO:0006268)4.54030990
3CENP-A containing nucleosome assembly (GO:0034080)4.50842093
4kinetochore organization (GO:0051383)4.49010603
5chromatin remodeling at centromere (GO:0031055)4.44981257
6maturation of SSU-rRNA (GO:0030490)4.34974655
7DNA strand elongation involved in DNA replication (GO:0006271)4.26888913
8translational termination (GO:0006415)4.17054273
9viral transcription (GO:0019083)4.16598178
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.15012662
11DNA replication initiation (GO:0006270)4.14567676
12telomere maintenance via semi-conservative replication (GO:0032201)4.09995544
13DNA replication-independent nucleosome organization (GO:0034724)4.09031801
14DNA replication-independent nucleosome assembly (GO:0006336)4.09031801
15DNA strand elongation (GO:0022616)4.05670407
16ribosomal small subunit biogenesis (GO:0042274)4.03557770
17establishment of integrated proviral latency (GO:0075713)4.01771231
18attachment of spindle microtubules to kinetochore (GO:0008608)3.96335712
19proteasome assembly (GO:0043248)3.92912799
20mitotic metaphase plate congression (GO:0007080)3.92292093
21DNA replication checkpoint (GO:0000076)3.92176431
22ribosomal large subunit biogenesis (GO:0042273)3.91001994
23telomere maintenance via recombination (GO:0000722)3.90690699
24mitotic recombination (GO:0006312)3.88501842
25protein localization to kinetochore (GO:0034501)3.80620388
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.79918557
27metaphase plate congression (GO:0051310)3.76740445
28kinetochore assembly (GO:0051382)3.72368495
29formation of translation preinitiation complex (GO:0001731)3.72214649
30DNA damage response, detection of DNA damage (GO:0042769)3.67065290
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65989194
32histone exchange (GO:0043486)3.64569584
33cotranslational protein targeting to membrane (GO:0006613)3.63353278
34translational elongation (GO:0006414)3.63240830
35DNA ligation (GO:0006266)3.59586893
36mitotic chromosome condensation (GO:0007076)3.58627748
37translational initiation (GO:0006413)3.58272908
38protein targeting to ER (GO:0045047)3.58040268
39IMP metabolic process (GO:0046040)3.57313265
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.56837493
41chaperone-mediated protein transport (GO:0072321)3.52200838
42nucleotide-excision repair, DNA gap filling (GO:0006297)3.48356848
43regulation of centriole replication (GO:0046599)3.48170816
44DNA topological change (GO:0006265)3.47187617
45DNA replication-dependent nucleosome assembly (GO:0006335)3.46757944
46DNA replication-dependent nucleosome organization (GO:0034723)3.46757944
47negative regulation of DNA-dependent DNA replication (GO:2000104)3.46365523
48establishment of chromosome localization (GO:0051303)3.46218837
49telomere maintenance via telomere lengthening (GO:0010833)3.46009893
50meiotic chromosome segregation (GO:0045132)3.44552545
51regulation of helicase activity (GO:0051095)3.43681389
52spliceosomal complex assembly (GO:0000245)3.43339330
53nuclear pore organization (GO:0006999)3.42947608
54energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42637772
55ATP synthesis coupled proton transport (GO:0015986)3.42637772
56regulation of mitotic spindle checkpoint (GO:1903504)3.41771625
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41771625
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.40397810
59ribonucleoprotein complex biogenesis (GO:0022613)3.38367664
60mitotic sister chromatid cohesion (GO:0007064)3.36155990
61protein localization to endoplasmic reticulum (GO:0070972)3.35381664
62cellular protein complex disassembly (GO:0043624)3.33585813
63spliceosomal snRNP assembly (GO:0000387)3.31162843
64ribosome assembly (GO:0042255)3.30502256
65spindle checkpoint (GO:0031577)3.29718384
66mitotic nuclear envelope disassembly (GO:0007077)3.28419560
67nuclear pore complex assembly (GO:0051292)3.28092234
68viral life cycle (GO:0019058)3.25774884
69spindle assembly checkpoint (GO:0071173)3.24720058
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22303777
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.20198083
72negative regulation of sister chromatid segregation (GO:0033046)3.20198083
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.20198083
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.20198083
75mitotic spindle assembly checkpoint (GO:0007094)3.19624600
76protein localization to chromosome, centromeric region (GO:0071459)3.19287666
77viral mRNA export from host cell nucleus (GO:0046784)3.18355530
78mitotic sister chromatid segregation (GO:0000070)3.17060342
79rRNA processing (GO:0006364)3.16750759
80nucleobase biosynthetic process (GO:0046112)3.15630712
81sister chromatid segregation (GO:0000819)3.15403040
82mitotic spindle checkpoint (GO:0071174)3.15351986
83termination of RNA polymerase III transcription (GO:0006386)3.14747165
84transcription elongation from RNA polymerase III promoter (GO:0006385)3.14747165
85negative regulation of chromosome segregation (GO:0051985)3.13651523
86negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13052587
87establishment of viral latency (GO:0019043)3.12426694
88IMP biosynthetic process (GO:0006188)3.09161505
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08312812
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08055872
91negative regulation of ligase activity (GO:0051352)3.06248248
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06248248
93non-recombinational repair (GO:0000726)3.06044961
94double-strand break repair via nonhomologous end joining (GO:0006303)3.06044961
95rRNA metabolic process (GO:0016072)3.04734549
96negative regulation of RNA splicing (GO:0033119)3.04502102
97RNA splicing, via transesterification reactions (GO:0000375)3.04023404
98mitotic G2/M transition checkpoint (GO:0044818)3.03999036
99membrane disassembly (GO:0030397)3.03530188
100nuclear envelope disassembly (GO:0051081)3.03530188
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03061412
102purine nucleobase biosynthetic process (GO:0009113)3.02398115
103RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02226650
104mRNA splicing, via spliceosome (GO:0000398)3.02226650
105nuclear-transcribed mRNA catabolic process (GO:0000956)3.01329127
106negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00735157
107transcription-coupled nucleotide-excision repair (GO:0006283)3.00640812
108ATP-dependent chromatin remodeling (GO:0043044)3.00528032
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00475151
110replication fork processing (GO:0031297)3.00200218
111DNA catabolic process, exonucleolytic (GO:0000738)3.00111125
112protein complex disassembly (GO:0043241)2.99404176
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.99330242
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98595596
115rRNA modification (GO:0000154)2.98174475
116chromatin assembly or disassembly (GO:0006333)2.97661279
117regulation of chromosome segregation (GO:0051983)2.97019428
118regulation of mitotic sister chromatid separation (GO:0010965)2.96943506
119regulation of mitotic sister chromatid segregation (GO:0033047)2.96943506
120regulation of sister chromatid segregation (GO:0033045)2.96943506
121DNA double-strand break processing (GO:0000729)2.96388047
122positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95971681
123telomere maintenance via telomerase (GO:0007004)2.94896969
124protein neddylation (GO:0045116)2.94058470
125cullin deneddylation (GO:0010388)2.93637735
126termination of RNA polymerase II transcription (GO:0006369)2.93428935
127maturation of 5.8S rRNA (GO:0000460)2.92559093
128negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92419776
129regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92379688
130ribosome biogenesis (GO:0042254)2.91214443
131pseudouridine synthesis (GO:0001522)2.91129811
132negative regulation of DNA recombination (GO:0045910)2.91045603
133DNA-templated transcription, termination (GO:0006353)2.90746311
134translation (GO:0006412)2.90323370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.08715261
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.58640279
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.31291336
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.99125438
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63234599
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.48444986
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.32154089
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.29521285
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25236058
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99311065
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85171611
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81717520
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80219531
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.78914810
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65616056
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60953439
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60618393
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.52822999
19ELK1_19687146_ChIP-ChIP_HELA_Human2.49626529
20* VDR_23849224_ChIP-Seq_CD4+_Human2.47886471
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.38919678
22XRN2_22483619_ChIP-Seq_HELA_Human2.38373602
23AR_21909140_ChIP-Seq_LNCAP_Human2.36005604
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34806414
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.27811265
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.23759404
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22837509
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17176915
29DCP1A_22483619_ChIP-Seq_HELA_Human2.16402512
30FOXP3_21729870_ChIP-Seq_TREG_Human2.13767626
31TTF2_22483619_ChIP-Seq_HELA_Human2.11092881
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10604870
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.09738679
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09352109
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.00260654
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98692476
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97823205
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93833317
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92443999
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91147995
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83898808
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80619836
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77890662
44* GABP_19822575_ChIP-Seq_HepG2_Human1.76168095
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72610664
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71876969
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65811587
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.63789224
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63618143
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60359671
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.58061455
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.56715578
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56481585
54CIITA_25753668_ChIP-Seq_RAJI_Human1.52884567
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49875766
56MYC_18940864_ChIP-ChIP_HL60_Human1.43041121
57* TP63_19390658_ChIP-ChIP_HaCaT_Human1.38986458
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36648151
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.32297845
60VDR_22108803_ChIP-Seq_LS180_Human1.30556898
61KDM5A_27292631_Chip-Seq_BREAST_Human1.26590257
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20976030
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18913723
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18849965
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.17732244
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17716583
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15990067
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15182300
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15182300
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15182300
71CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13853928
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13684759
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13158586
74EWS_26573619_Chip-Seq_HEK293_Human1.12174954
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09217304
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09166543
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08554746
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07697993
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.07687936
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.07179098
81FUS_26573619_Chip-Seq_HEK293_Human1.06679302
82ZNF274_21170338_ChIP-Seq_K562_Hela1.05883130
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00238170
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00193654
85TFEB_21752829_ChIP-Seq_HELA_Human0.99998932
86TAF15_26573619_Chip-Seq_HEK293_Human0.98174476
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98148450
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98031162
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97999617
90* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97489248
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96900890
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96433939
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.93635338
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93351677
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89566940
96HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89435415
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89297980
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89004740
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88028328
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.87820665
101MYC_22102868_ChIP-Seq_BL_Human0.87790306
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85110522
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84393682
104IRF1_19129219_ChIP-ChIP_H3396_Human0.83249721
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82996550
106IGF1R_20145208_ChIP-Seq_DFB_Human0.81053948
107* P300_19829295_ChIP-Seq_ESCs_Human0.81031999
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80862206
109SPI1_23547873_ChIP-Seq_NB4_Human0.80840378
110RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77630169
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76719524
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76541845
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75911098
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.74775485
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.73911983
116GATA1_26923725_Chip-Seq_HPCs_Mouse0.73466683
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72663749
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71889866
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.71170114
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67940618
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.66476483
122TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66005436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.76491910
2MP0010094_abnormal_chromosome_stability4.39873413
3MP0008057_abnormal_DNA_replication4.16811885
4* MP0004957_abnormal_blastocyst_morpholog4.05825562
5MP0003077_abnormal_cell_cycle3.65593410
6MP0003111_abnormal_nucleus_morphology3.59648049
7MP0008058_abnormal_DNA_repair3.22874806
8MP0008007_abnormal_cellular_replicative3.05792745
9MP0003123_paternal_imprinting3.02513987
10MP0008932_abnormal_embryonic_tissue2.74201478
11MP0008877_abnormal_DNA_methylation2.49950959
12MP0003121_genomic_imprinting2.38181239
13MP0002396_abnormal_hematopoietic_system2.30444750
14MP0009379_abnormal_foot_pigmentation2.00129660
15MP0000350_abnormal_cell_proliferation1.99175561
16MP0001730_embryonic_growth_arrest1.96131724
17MP0003786_premature_aging1.90710438
18MP0006054_spinal_hemorrhage1.90671552
19MP0003136_yellow_coat_color1.76902967
20MP0003315_abnormal_perineum_morphology1.64390841
21MP0002938_white_spotting1.59373557
22MP0001697_abnormal_embryo_size1.53070397
23MP0003567_abnormal_fetal_cardiomyocyte1.50535676
24MP0010352_gastrointestinal_tract_polyps1.49135856
25MP0006292_abnormal_olfactory_placode1.44861838
26MP0009672_abnormal_birth_weight1.44762316
27MP0004808_abnormal_hematopoietic_stem1.44433394
28MP0003186_abnormal_redox_activity1.42189541
29MP0000490_abnormal_crypts_of1.42085862
30MP0000537_abnormal_urethra_morphology1.39297447
31MP0002697_abnormal_eye_size1.38400747
32* MP0002085_abnormal_embryonic_tissue1.37857354
33MP0002102_abnormal_ear_morphology1.37819397
34MP0010030_abnormal_orbit_morphology1.36595512
35MP0005380_embryogenesis_phenotype1.34674438
36MP0001672_abnormal_embryogenesis/_devel1.34674438
37MP0002084_abnormal_developmental_patter1.34574418
38MP0003890_abnormal_embryonic-extraembry1.31588498
39MP0003806_abnormal_nucleotide_metabolis1.31306572
40MP0003787_abnormal_imprinting1.29594533
41MP0003718_maternal_effect1.28275048
42MP0002080_prenatal_lethality1.27615096
43MP0008995_early_reproductive_senescence1.26235842
44MP0002233_abnormal_nose_morphology1.24360339
45MP0002210_abnormal_sex_determination1.23893375
46MP0010307_abnormal_tumor_latency1.22615498
47MP0004197_abnormal_fetal_growth/weight/1.22378064
48MP0003937_abnormal_limbs/digits/tail_de1.21376664
49MP0000313_abnormal_cell_death1.18684723
50MP0003122_maternal_imprinting1.17086960
51MP0006035_abnormal_mitochondrial_morpho1.16196372
52MP0003984_embryonic_growth_retardation1.15597222
53MP0005394_taste/olfaction_phenotype1.13282214
54MP0005499_abnormal_olfactory_system1.13282214
55MP0002736_abnormal_nociception_after1.12780826
56MP0002088_abnormal_embryonic_growth/wei1.11579409
57MP0001293_anophthalmia1.10711922
58MP0004133_heterotaxia1.09906223
59MP0002019_abnormal_tumor_incidence1.09493683
60MP0001188_hyperpigmentation1.07414246
61MP0006036_abnormal_mitochondrial_physio1.05192967
62MP0001145_abnormal_male_reproductive1.03933331
63MP0009703_decreased_birth_body1.03152306
64* MP0002086_abnormal_extraembryonic_tissu1.02939150
65MP0002234_abnormal_pharynx_morphology1.01801723
66MP0003941_abnormal_skin_development1.00732839
67MP0000703_abnormal_thymus_morphology1.00201965
68MP0003763_abnormal_thymus_physiology0.97320094
69MP0000653_abnormal_sex_gland0.96524391
70MP0002160_abnormal_reproductive_system0.95462161
71MP0002095_abnormal_skin_pigmentation0.94681873
72MP0001529_abnormal_vocalization0.94581964
73MP0000631_abnormal_neuroendocrine_gland0.94322925
74MP0000049_abnormal_middle_ear0.93437701
75MP0001299_abnormal_eye_distance/0.89349930
76MP0002751_abnormal_autonomic_nervous0.89073020
77MP0002282_abnormal_trachea_morphology0.88874998
78MP0001929_abnormal_gametogenesis0.87816823
79MP0000647_abnormal_sebaceous_gland0.85126738
80MP0009053_abnormal_anal_canal0.84317189
81MP0001119_abnormal_female_reproductive0.84284618
82MP0005389_reproductive_system_phenotype0.84108400
83MP0009697_abnormal_copulation0.84036582
84MP0005391_vision/eye_phenotype0.83202407
85MP0001286_abnormal_eye_development0.83099857
86MP0009333_abnormal_splenocyte_physiolog0.82963793
87MP0002398_abnormal_bone_marrow0.81989449
88MP0005084_abnormal_gallbladder_morpholo0.81809525
89MP0004147_increased_porphyrin_level0.81131187
90MP0000358_abnormal_cell_content/0.80648280
91MP0005187_abnormal_penis_morphology0.79686773
92MP0002163_abnormal_gland_morphology0.78432168
93MP0008789_abnormal_olfactory_epithelium0.78134346
94MP0002092_abnormal_eye_morphology0.77438978
95MP0001485_abnormal_pinna_reflex0.77080405
96MP0005253_abnormal_eye_physiology0.76838050
97MP0003755_abnormal_palate_morphology0.76180171
98MP0000372_irregular_coat_pigmentation0.74554963
99MP0001545_abnormal_hematopoietic_system0.72517969
100MP0005397_hematopoietic_system_phenotyp0.72517969
101MP0003385_abnormal_body_wall0.71754788
102MP0002722_abnormal_immune_system0.70783770
103MP0001984_abnormal_olfaction0.70543687
104MP0001177_atelectasis0.70169507
105MP0002114_abnormal_axial_skeleton0.70165528
106MP0000428_abnormal_craniofacial_morphol0.69970893
107MP0002932_abnormal_joint_morphology0.69867510
108MP0009250_abnormal_appendicular_skeleto0.69537204
109MP0002111_abnormal_tail_morphology0.69488899
110MP0003942_abnormal_urinary_system0.68132643
111MP0000516_abnormal_urinary_system0.67101916
112MP0005367_renal/urinary_system_phenotyp0.67101916
113MP0003119_abnormal_digestive_system0.66517020
114MP0003698_abnormal_male_reproductive0.65614351
115MP0002254_reproductive_system_inflammat0.65486206
116MP0006072_abnormal_retinal_apoptosis0.64717640
117MP0000579_abnormal_nail_morphology0.64406055
118MP0003935_abnormal_craniofacial_develop0.63941690
119MP0000689_abnormal_spleen_morphology0.63798884
120MP0001915_intracranial_hemorrhage0.63693526
121MP0003861_abnormal_nervous_system0.63259893
122MP0003221_abnormal_cardiomyocyte_apopto0.62537702
123MP0000465_gastrointestinal_hemorrhage0.61073906
124MP0000432_abnormal_head_morphology0.60723552
125MP0001919_abnormal_reproductive_system0.59724660
126MP0003938_abnormal_ear_development0.59297787
127MP0005384_cellular_phenotype0.59164138
128MP0002177_abnormal_outer_ear0.58332083
129MP0005174_abnormal_tail_pigmentation0.56718379
130MP0002429_abnormal_blood_cell0.56157882
131MP0002132_abnormal_respiratory_system0.55191914
132MP0002116_abnormal_craniofacial_bone0.54284780

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.41352801
2Reticulocytopenia (HP:0001896)4.18286286
3Abnormality of cells of the erythroid lineage (HP:0012130)4.08938394
4Abnormal number of erythroid precursors (HP:0012131)3.78147516
5Colon cancer (HP:0003003)3.75725955
6Aplastic anemia (HP:0001915)3.41493597
7Medulloblastoma (HP:0002885)3.32892201
8Chromsome breakage (HP:0040012)3.32383656
9Acute encephalopathy (HP:0006846)3.23667737
10Volvulus (HP:0002580)3.11366223
11Oral leukoplakia (HP:0002745)2.95080240
12Pallor (HP:0000980)2.91279450
13Breast hypoplasia (HP:0003187)2.86119359
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84693200
15Patellar aplasia (HP:0006443)2.82811846
16Septo-optic dysplasia (HP:0100842)2.81329496
17Abnormality of chromosome stability (HP:0003220)2.80515991
18Macrocytic anemia (HP:0001972)2.76174519
1911 pairs of ribs (HP:0000878)2.67233413
20Multiple enchondromatosis (HP:0005701)2.62260884
21Aplasia/Hypoplasia of the patella (HP:0006498)2.61327800
22Meckel diverticulum (HP:0002245)2.58168658
23Abnormality of the preputium (HP:0100587)2.57546003
24Abnormality of methionine metabolism (HP:0010901)2.57136045
25Myelodysplasia (HP:0002863)2.49533821
26Abnormal lung lobation (HP:0002101)2.48341764
27Cerebral edema (HP:0002181)2.45678179
28Hyperglycinemia (HP:0002154)2.42943460
29Selective tooth agenesis (HP:0001592)2.42822943
30Abnormality of the ileum (HP:0001549)2.42685469
31Cortical dysplasia (HP:0002539)2.41865186
32Supernumerary spleens (HP:0009799)2.39369928
33Nephroblastoma (Wilms tumor) (HP:0002667)2.39340424
34Agnosia (HP:0010524)2.36956450
35Proximal placement of thumb (HP:0009623)2.36139660
36Methylmalonic acidemia (HP:0002912)2.34470529
37Abnormal number of incisors (HP:0011064)2.32099201
38Premature graying of hair (HP:0002216)2.31973775
39Embryonal renal neoplasm (HP:0011794)2.30354592
40Abnormality of the labia minora (HP:0012880)2.30156735
41Rhabdomyosarcoma (HP:0002859)2.30009757
42Abnormality of the anterior horn cell (HP:0006802)2.29475081
43Degeneration of anterior horn cells (HP:0002398)2.29475081
44Abnormality of serum amino acid levels (HP:0003112)2.29396045
45Small intestinal stenosis (HP:0012848)2.28418102
46Duodenal stenosis (HP:0100867)2.28418102
47Deviation of the thumb (HP:0009603)2.28192660
48Atresia of the external auditory canal (HP:0000413)2.26719885
49Renal Fanconi syndrome (HP:0001994)2.25161998
50Rough bone trabeculation (HP:0100670)2.23180774
51Glossoptosis (HP:0000162)2.18918299
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.18708022
53Megaloblastic anemia (HP:0001889)2.15625967
54Homocystinuria (HP:0002156)2.15437579
55Abnormality of homocysteine metabolism (HP:0010919)2.15437579
56Increased hepatocellular lipid droplets (HP:0006565)2.13943950
57Absent radius (HP:0003974)2.12850808
58Hepatocellular necrosis (HP:0001404)2.11559361
59Absent septum pellucidum (HP:0001331)2.11353783
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10469057
61Acute necrotizing encephalopathy (HP:0006965)2.10047152
62Increased nuchal translucency (HP:0010880)2.09397624
63Horseshoe kidney (HP:0000085)2.06338744
64Stenosis of the external auditory canal (HP:0000402)2.05795961
65Short middle phalanx of the 5th finger (HP:0004220)2.02102072
66Sloping forehead (HP:0000340)2.02048029
67Neoplasm of the pancreas (HP:0002894)2.01992714
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.01094456
69Absent forearm bone (HP:0003953)2.00497108
70Aplasia involving forearm bones (HP:0009822)2.00497108
71Abnormality of the septum pellucidum (HP:0007375)2.00294294
72Absent thumb (HP:0009777)1.99761017
73Leukodystrophy (HP:0002415)1.98669538
74Increased serum lactate (HP:0002151)1.97751934
75Facial hemangioma (HP:0000329)1.94995703
76Respiratory difficulties (HP:0002880)1.93181000
77Bifid tongue (HP:0010297)1.91846817
78Hepatic necrosis (HP:0002605)1.91516367
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89819948
80Abnormality of alanine metabolism (HP:0010916)1.89819948
81Hyperalaninemia (HP:0003348)1.89819948
82Triphalangeal thumb (HP:0001199)1.89472308
83Bone marrow hypocellularity (HP:0005528)1.89413435
84Thrombocytosis (HP:0001894)1.88943339
85Congenital, generalized hypertrichosis (HP:0004540)1.88577138
86Pancreatic islet-cell hyperplasia (HP:0004510)1.88070252
87Cerebral hypomyelination (HP:0006808)1.86353111
88Neoplasm of the colon (HP:0100273)1.85899893
89Pancreatic fibrosis (HP:0100732)1.85377686
90Ectopic kidney (HP:0000086)1.85308241
91Optic nerve coloboma (HP:0000588)1.84771972
92Glioma (HP:0009733)1.84613063
93Abnormality of the duodenum (HP:0002246)1.84377015
94Abnormal mitochondria in muscle tissue (HP:0008316)1.83956125
95Microvesicular hepatic steatosis (HP:0001414)1.82252944
96Carpal bone hypoplasia (HP:0001498)1.81838379
97Microretrognathia (HP:0000308)1.81502613
98Ependymoma (HP:0002888)1.81500851
99Hypoplasia of the pons (HP:0012110)1.80384892
100Mitochondrial inheritance (HP:0001427)1.79907683
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79791935
102Abnormality of the carotid arteries (HP:0005344)1.79775253
103Hyperglycinuria (HP:0003108)1.79732776
104Progressive macrocephaly (HP:0004481)1.79540031
105Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79200004
106Abnormality of the pons (HP:0007361)1.77730259
107Cellular immunodeficiency (HP:0005374)1.77570363
108Basal cell carcinoma (HP:0002671)1.77204182
109Abnormality of serine family amino acid metabolism (HP:0010894)1.76929563
110Abnormality of glycine metabolism (HP:0010895)1.76929563
111Bilateral microphthalmos (HP:0007633)1.75464134
112Intestinal atresia (HP:0011100)1.75444656
113Lactic acidosis (HP:0003128)1.74536203
114Increased CSF lactate (HP:0002490)1.74393722
115Facial cleft (HP:0002006)1.73529927
116Abnormal trabecular bone morphology (HP:0100671)1.71893035
117Slender long bone (HP:0003100)1.70799786
118Spastic diplegia (HP:0001264)1.70514210
119Acute myeloid leukemia (HP:0004808)1.69934129
120Short thumb (HP:0009778)1.69784262
121Irregular epiphyses (HP:0010582)1.69533636
122Ovarian neoplasm (HP:0100615)1.68573934
123Depressed nasal ridge (HP:0000457)1.68296965
124Exercise intolerance (HP:0003546)1.67688935
125Amaurosis fugax (HP:0100576)1.65828196
126Lipid accumulation in hepatocytes (HP:0006561)1.64986866
127Maternal diabetes (HP:0009800)1.64825183
128Abnormality of glycolysis (HP:0004366)1.63929469
129Increased serum pyruvate (HP:0003542)1.63929469
130Missing ribs (HP:0000921)1.63793783
131Lymphoma (HP:0002665)1.63234322
132Shoulder girdle muscle weakness (HP:0003547)1.63172930
133Exertional dyspnea (HP:0002875)1.62779694
134Cleft eyelid (HP:0000625)1.61936019
135Pancytopenia (HP:0001876)1.61698095
136Tracheoesophageal fistula (HP:0002575)1.60601605
137Asplenia (HP:0001746)1.59172336
138Calcaneovalgus deformity (HP:0001848)1.58905713
139Abnormality of the calcaneus (HP:0008364)1.58176598
140Type I transferrin isoform profile (HP:0003642)1.57504806
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.56760381
142Decreased activity of mitochondrial respiratory chain (HP:0008972)1.56760381
143Biliary tract neoplasm (HP:0100574)1.56528051
144Pancreatic cysts (HP:0001737)1.55226821

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.79106947
2WEE14.12526824
3BUB13.67529661
4STK163.20760620
5EIF2AK13.07784721
6SRPK13.06899867
7MKNK12.80259316
8VRK22.77885472
9ACVR1B2.67514576
10TNIK2.56172460
11TSSK62.52693079
12VRK12.29489073
13BRSK22.24077844
14NEK22.14690720
15PASK2.01837510
16TTK2.01548572
17PLK32.00920855
18MKNK21.99004479
19PLK41.96651625
20EIF2AK31.95625108
21TRIM281.94798306
22PLK11.92333288
23TAF11.80418821
24AURKB1.72698880
25TGFBR11.69403559
26ATR1.67103764
27NME21.60258757
28NEK11.59965108
29PNCK1.57568252
30WNK31.54062293
31RPS6KB21.49675699
32DYRK31.41076178
33CDK71.40086775
34PBK1.39839788
35CDK81.38460920
36MST41.27784464
37CHEK21.22322388
38CHEK11.21310571
39RPS6KA41.20769234
40BRSK11.20128715
41CCNB11.19940067
42TESK21.16649382
43TLK11.15785734
44SCYL21.13773777
45AURKA1.09694375
46MAP3K81.07512169
47NUAK11.05953579
48ATM1.04552778
49ERBB31.00161938
50CDK40.85868089
51STK38L0.85608749
52CSNK1G30.84388707
53STK100.83216341
54* CSNK2A20.81091998
55LIMK10.80856145
56PAK40.79555821
57NME10.79508361
58CDK120.78628583
59BRD40.78623350
60TEC0.77942339
61CDK20.77790096
62* CSNK2A10.77214618
63PDK20.76991111
64LATS10.75653500
65MELK0.74326862
66YES10.72184849
67CDK10.70976713
68MAP3K40.70511367
69EIF2AK20.69936605
70BMPR1B0.67750018
71PLK20.67095637
72LATS20.66469635
73LRRK20.63316497
74ZAK0.63181806
75FGFR10.62832532
76CDK30.62612204
77BCR0.59602002
78RPS6KA50.59295643
79CSNK1G10.58055207
80STK40.58026291
81CSNK1A1L0.57648652
82DYRK20.57507338
83ERBB40.57294915
84MAP4K20.56253673
85CDK60.53033527
86PIM20.52818740
87PIM10.50692968
88BRAF0.49039655
89STK240.48175276
90ILK0.45605827
91CSNK1E0.45282164
92CLK10.45201978
93STK30.44818993
94CASK0.44248066
95TESK10.43782001
96MAP3K100.42959626
97PRKDC0.41157822
98PAK10.37953745
99FLT30.35065897
100TXK0.34858897
101EEF2K0.34225531
102PRKCG0.33935033
103MINK10.33669349
104RAF10.33539884
105CSNK1G20.33492589
106MAPK130.30124533
107MAP3K120.30124127
108CDK180.30089913
109DMPK0.28819982
110BTK0.28323392
111OXSR10.28099888
112MAPK140.28069050
113NLK0.27532138
114CDK150.24198831
115RPS6KB10.24159398
116PRKACB0.23742201
117CDK90.23476104
118CDK140.22472906
119PRKCI0.21763830
120CSNK1A10.21621474
121CDK190.21332343
122GRK10.21255012
123MAP3K60.21082489
124TIE10.20871913
125CSNK1D0.19959379
126JAK30.19927641
127ALK0.19785929
128KDR0.19041518
129CDK11A0.18446631
130PAK20.17894307

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.53448991
2Mismatch repair_Homo sapiens_hsa034304.02960433
3Ribosome_Homo sapiens_hsa030103.87893242
4Spliceosome_Homo sapiens_hsa030403.53822867
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.38118484
6Proteasome_Homo sapiens_hsa030503.33652851
7RNA polymerase_Homo sapiens_hsa030203.06057958
8Homologous recombination_Homo sapiens_hsa034403.02162411
9Nucleotide excision repair_Homo sapiens_hsa034202.98729628
10RNA transport_Homo sapiens_hsa030132.97788340
11Cell cycle_Homo sapiens_hsa041102.77909439
12Base excision repair_Homo sapiens_hsa034102.70468762
13Non-homologous end-joining_Homo sapiens_hsa034502.42102140
14Basal transcription factors_Homo sapiens_hsa030222.22764190
15RNA degradation_Homo sapiens_hsa030182.21373676
16Fanconi anemia pathway_Homo sapiens_hsa034602.19654894
17Pyrimidine metabolism_Homo sapiens_hsa002402.17260214
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.05778078
19One carbon pool by folate_Homo sapiens_hsa006701.88767821
20mRNA surveillance pathway_Homo sapiens_hsa030151.87503320
21Protein export_Homo sapiens_hsa030601.81385466
22Propanoate metabolism_Homo sapiens_hsa006401.60091820
23Pyruvate metabolism_Homo sapiens_hsa006201.50721704
24p53 signaling pathway_Homo sapiens_hsa041151.42942844
25Steroid biosynthesis_Homo sapiens_hsa001001.41733659
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40015961
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39812509
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36394668
29Purine metabolism_Homo sapiens_hsa002301.25085316
30Selenocompound metabolism_Homo sapiens_hsa004501.21406580
31Oocyte meiosis_Homo sapiens_hsa041141.18293690
32Epstein-Barr virus infection_Homo sapiens_hsa051691.17621528
33Parkinsons disease_Homo sapiens_hsa050121.15408073
34Vitamin B6 metabolism_Homo sapiens_hsa007501.14056690
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10663379
36Huntingtons disease_Homo sapiens_hsa050161.08258940
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08178960
38* Systemic lupus erythematosus_Homo sapiens_hsa053221.04300900
39Folate biosynthesis_Homo sapiens_hsa007901.02719424
40Antigen processing and presentation_Homo sapiens_hsa046121.02328240
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02306623
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02244543
43Oxidative phosphorylation_Homo sapiens_hsa001901.01634474
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01019290
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96799133
46Biosynthesis of amino acids_Homo sapiens_hsa012300.93739264
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92900089
48Viral carcinogenesis_Homo sapiens_hsa052030.90645894
49Herpes simplex infection_Homo sapiens_hsa051680.88401452
50Carbon metabolism_Homo sapiens_hsa012000.86159400
51Fatty acid elongation_Homo sapiens_hsa000620.82452765
52Cardiac muscle contraction_Homo sapiens_hsa042600.77944638
53HTLV-I infection_Homo sapiens_hsa051660.77011113
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73925312
55TGF-beta signaling pathway_Homo sapiens_hsa043500.70365210
56Alcoholism_Homo sapiens_hsa050340.70249020
57Thyroid cancer_Homo sapiens_hsa052160.68538244
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68105566
59MicroRNAs in cancer_Homo sapiens_hsa052060.66544496
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60976952
61Alzheimers disease_Homo sapiens_hsa050100.60853477
62Metabolic pathways_Homo sapiens_hsa011000.60350819
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59622371
64Colorectal cancer_Homo sapiens_hsa052100.56283322
65Legionellosis_Homo sapiens_hsa051340.54049601
66Butanoate metabolism_Homo sapiens_hsa006500.53952961
67Primary immunodeficiency_Homo sapiens_hsa053400.50929519
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50911208
69Small cell lung cancer_Homo sapiens_hsa052220.50027997
70Vitamin digestion and absorption_Homo sapiens_hsa049770.49436926
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48242010
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47886670
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47314719
74N-Glycan biosynthesis_Homo sapiens_hsa005100.46193050
75Hippo signaling pathway_Homo sapiens_hsa043900.46157850
76Shigellosis_Homo sapiens_hsa051310.44129468
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43602273
78Hepatitis B_Homo sapiens_hsa051610.42709762
79Hematopoietic cell lineage_Homo sapiens_hsa046400.41865881
80Fatty acid metabolism_Homo sapiens_hsa012120.40886108
81Basal cell carcinoma_Homo sapiens_hsa052170.40724024
82Measles_Homo sapiens_hsa051620.40428351
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36497991
84Arginine and proline metabolism_Homo sapiens_hsa003300.35753903
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35309518
86Sulfur relay system_Homo sapiens_hsa041220.35041311
87Autoimmune thyroid disease_Homo sapiens_hsa053200.34987721
88Asthma_Homo sapiens_hsa053100.34907534
89Pathways in cancer_Homo sapiens_hsa052000.34014275
90Peroxisome_Homo sapiens_hsa041460.33641389
91Wnt signaling pathway_Homo sapiens_hsa043100.33238844
92beta-Alanine metabolism_Homo sapiens_hsa004100.32946625
93Allograft rejection_Homo sapiens_hsa053300.32164350
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32155092
95Fatty acid degradation_Homo sapiens_hsa000710.31033542
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29135566
97Viral myocarditis_Homo sapiens_hsa054160.28699989
98Type I diabetes mellitus_Homo sapiens_hsa049400.26128805
99Apoptosis_Homo sapiens_hsa042100.25990131
100Prostate cancer_Homo sapiens_hsa052150.25737663
101Hedgehog signaling pathway_Homo sapiens_hsa043400.25508630
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25070490
103Sulfur metabolism_Homo sapiens_hsa009200.24955875
104Tryptophan metabolism_Homo sapiens_hsa003800.24912314
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23733622
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23172244
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.22341672
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.21956475
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21145626
110Adherens junction_Homo sapiens_hsa045200.20577763
111RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20526386
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.19072533
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18505518
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18250689
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17970170
116Nicotine addiction_Homo sapiens_hsa050330.17514275
117Glutathione metabolism_Homo sapiens_hsa004800.17204569
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.16862676
119Notch signaling pathway_Homo sapiens_hsa043300.16732348
120Pancreatic cancer_Homo sapiens_hsa052120.16611383
121Influenza A_Homo sapiens_hsa051640.16408006
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16342180
123Retinol metabolism_Homo sapiens_hsa008300.16203483
124Lysine degradation_Homo sapiens_hsa003100.16159839
125Nitrogen metabolism_Homo sapiens_hsa009100.16144432
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15471032
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.14996176
128Phototransduction_Homo sapiens_hsa047440.13257314
129Melanoma_Homo sapiens_hsa052180.12996053
130Arachidonic acid metabolism_Homo sapiens_hsa005900.12819923
131T cell receptor signaling pathway_Homo sapiens_hsa046600.12505235
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12389703
133Caffeine metabolism_Homo sapiens_hsa002320.12382757
134Chronic myeloid leukemia_Homo sapiens_hsa052200.12298516
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.11975919
136HIF-1 signaling pathway_Homo sapiens_hsa040660.11182462
137Tight junction_Homo sapiens_hsa045300.10798117
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10011573
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09600199
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09515064
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08382216
142Graft-versus-host disease_Homo sapiens_hsa053320.07618782
143Pentose phosphate pathway_Homo sapiens_hsa000300.06946456
144Fat digestion and absorption_Homo sapiens_hsa049750.06412542
145Olfactory transduction_Homo sapiens_hsa047400.06234373
146Bladder cancer_Homo sapiens_hsa052190.05600473

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