

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.73301846 |
| 2 | DNA deamination (GO:0045006) | 5.30363479 |
| 3 | chaperone-mediated protein transport (GO:0072321) | 5.29165142 |
| 4 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.24754572 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 5.14624064 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.92869434 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 4.90827412 |
| 8 | viral transcription (GO:0019083) | 4.84077828 |
| 9 | ribosomal large subunit biogenesis (GO:0042273) | 4.80400117 |
| 10 | translational termination (GO:0006415) | 4.73201549 |
| 11 | respiratory electron transport chain (GO:0022904) | 4.68672952 |
| 12 | electron transport chain (GO:0022900) | 4.57764458 |
| 13 | proteasome assembly (GO:0043248) | 4.48059559 |
| 14 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.42695943 |
| 15 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.40809266 |
| 16 | cotranslational protein targeting to membrane (GO:0006613) | 4.36735092 |
| 17 | CENP-A containing nucleosome assembly (GO:0034080) | 4.31573320 |
| 18 | protein targeting to ER (GO:0045047) | 4.30968645 |
| 19 | chromatin remodeling at centromere (GO:0031055) | 4.24410255 |
| 20 | translational elongation (GO:0006414) | 4.17844961 |
| 21 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.14788185 |
| 22 | telomere maintenance via recombination (GO:0000722) | 4.10706556 |
| 23 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.10379294 |
| 24 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.09559586 |
| 25 | protein localization to endoplasmic reticulum (GO:0070972) | 4.08096074 |
| 26 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.08058521 |
| 27 | DNA strand elongation (GO:0022616) | 4.00711910 |
| 28 | translational initiation (GO:0006413) | 3.94169084 |
| 29 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.91830047 |
| 30 | termination of RNA polymerase III transcription (GO:0006386) | 3.91830047 |
| 31 | protein neddylation (GO:0045116) | 3.87648404 |
| 32 | kinetochore organization (GO:0051383) | 3.83671270 |
| 33 | translation (GO:0006412) | 3.83163413 |
| 34 | DNA replication initiation (GO:0006270) | 3.78236216 |
| 35 | mitotic recombination (GO:0006312) | 3.74603291 |
| 36 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.72924705 |
| 37 | viral life cycle (GO:0019058) | 3.70246893 |
| 38 | rRNA processing (GO:0006364) | 3.69795494 |
| 39 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.69387361 |
| 40 | kinetochore assembly (GO:0051382) | 3.68723203 |
| 41 | cellular protein complex disassembly (GO:0043624) | 3.68041834 |
| 42 | spliceosomal snRNP assembly (GO:0000387) | 3.66004163 |
| 43 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.65466705 |
| 44 | protein targeting to mitochondrion (GO:0006626) | 3.65146270 |
| 45 | pseudouridine synthesis (GO:0001522) | 3.64230656 |
| 46 | rRNA modification (GO:0000154) | 3.62663637 |
| 47 | formation of translation preinitiation complex (GO:0001731) | 3.60142217 |
| 48 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.59702834 |
| 49 | RNA capping (GO:0036260) | 3.58381880 |
| 50 | 7-methylguanosine RNA capping (GO:0009452) | 3.58381880 |
| 51 | rRNA metabolic process (GO:0016072) | 3.58120086 |
| 52 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.57884884 |
| 53 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.57784841 |
| 54 | cellular component biogenesis (GO:0044085) | 3.57417504 |
| 55 | 7-methylguanosine mRNA capping (GO:0006370) | 3.56373573 |
| 56 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.55355947 |
| 57 | DNA replication-independent nucleosome organization (GO:0034724) | 3.55355947 |
| 58 | viral mRNA export from host cell nucleus (GO:0046784) | 3.54947778 |
| 59 | telomere maintenance via telomere lengthening (GO:0010833) | 3.54068758 |
| 60 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.53956309 |
| 61 | termination of RNA polymerase I transcription (GO:0006363) | 3.53021359 |
| 62 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.52795472 |
| 63 | ATP synthesis coupled proton transport (GO:0015986) | 3.52795472 |
| 64 | establishment of integrated proviral latency (GO:0075713) | 3.51433431 |
| 65 | inner mitochondrial membrane organization (GO:0007007) | 3.50819896 |
| 66 | oxidative phosphorylation (GO:0006119) | 3.50428238 |
| 67 | DNA damage response, detection of DNA damage (GO:0042769) | 3.50303735 |
| 68 | DNA replication checkpoint (GO:0000076) | 3.49961482 |
| 69 | ribosome biogenesis (GO:0042254) | 3.49363218 |
| 70 | establishment of viral latency (GO:0019043) | 3.48879007 |
| 71 | nucleobase biosynthetic process (GO:0046112) | 3.47003479 |
| 72 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.46459003 |
| 73 | protein localization to mitochondrion (GO:0070585) | 3.42832766 |
| 74 | spliceosomal complex assembly (GO:0000245) | 3.42421441 |
| 75 | establishment of protein localization to mitochondrion (GO:0072655) | 3.42352846 |
| 76 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.42003941 |
| 77 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.41402558 |
| 78 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.39560375 |
| 79 | transcription from RNA polymerase I promoter (GO:0006360) | 3.38535846 |
| 80 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.38533687 |
| 81 | purine nucleobase biosynthetic process (GO:0009113) | 3.36953198 |
| 82 | mitotic metaphase plate congression (GO:0007080) | 3.36919994 |
| 83 | cullin deneddylation (GO:0010388) | 3.35629266 |
| 84 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.33613506 |
| 85 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.32896310 |
| 86 | negative regulation of ligase activity (GO:0051352) | 3.32896310 |
| 87 | histone exchange (GO:0043486) | 3.32777059 |
| 88 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.30487527 |
| 89 | NADH dehydrogenase complex assembly (GO:0010257) | 3.30487527 |
| 90 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.30487527 |
| 91 | regulation of mitochondrial translation (GO:0070129) | 3.27029282 |
| 92 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.25940454 |
| 93 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.24321092 |
| 94 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.24321092 |
| 95 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.24321092 |
| 96 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.23450612 |
| 97 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.23450612 |
| 98 | protein complex disassembly (GO:0043241) | 3.22864691 |
| 99 | positive regulation of ligase activity (GO:0051351) | 3.22791806 |
| 100 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.18724209 |
| 101 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.18724209 |
| 102 | ribosome assembly (GO:0042255) | 3.18444351 |
| 103 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.18005897 |
| 104 | ATP biosynthetic process (GO:0006754) | 3.16970727 |
| 105 | cytochrome complex assembly (GO:0017004) | 3.15755969 |
| 106 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.14514799 |
| 107 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.14514799 |
| 108 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.14272685 |
| 109 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.14272685 |
| 110 | protein localization to kinetochore (GO:0034501) | 3.14174990 |
| 111 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.12409237 |
| 112 | histone mRNA metabolic process (GO:0008334) | 3.12027478 |
| 113 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.11900733 |
| 114 | protein deneddylation (GO:0000338) | 3.11138594 |
| 115 | macromolecular complex disassembly (GO:0032984) | 3.10898811 |
| 116 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.09662702 |
| 117 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.09630500 |
| 118 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.09501397 |
| 119 | protein complex biogenesis (GO:0070271) | 3.06493796 |
| 120 | metaphase plate congression (GO:0051310) | 3.06359212 |
| 121 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.05451274 |
| 122 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.05353022 |
| 123 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.02183036 |
| 124 | DNA-templated transcription, termination (GO:0006353) | 3.00370781 |
| 125 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.00143684 |
| 126 | IMP biosynthetic process (GO:0006188) | 3.00138462 |
| 127 | maturation of 5.8S rRNA (GO:0000460) | 3.00086431 |
| 128 | respiratory chain complex IV assembly (GO:0008535) | 2.99622812 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.42732534 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.62614081 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.42678527 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.94830793 |
| 5 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.89023969 |
| 6 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.64615792 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.44485750 |
| 8 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.33538863 |
| 9 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.25832008 |
| 10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.25215550 |
| 11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.06752238 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.06735003 |
| 13 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.01332951 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.98740189 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.91852029 |
| 16 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.90299808 |
| 17 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.89024124 |
| 18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.84405577 |
| 19 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.80686022 |
| 20 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.78302570 |
| 21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.69546904 |
| 22 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.40926111 |
| 23 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.39629439 |
| 24 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.38630868 |
| 25 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.33920697 |
| 26 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.32948951 |
| 27 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.31397549 |
| 28 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.31089139 |
| 29 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.29511775 |
| 30 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 2.27514174 |
| 31 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.16591231 |
| 32 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.14810787 |
| 33 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.12492546 |
| 34 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.05728836 |
| 35 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.04151906 |
| 36 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.98016425 |
| 37 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.97342840 |
| 38 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.94633740 |
| 39 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.87397193 |
| 40 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.86430554 |
| 41 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.84543466 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.83998576 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.79371695 |
| 44 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.77417251 |
| 45 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.75137790 |
| 46 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.73563020 |
| 47 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70639418 |
| 48 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.68398680 |
| 49 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.64506498 |
| 50 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.64051517 |
| 51 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.63990987 |
| 52 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.58998306 |
| 53 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.58081106 |
| 54 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.56675307 |
| 55 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.54585513 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.47771074 |
| 57 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.47259084 |
| 58 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.40236696 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.39723041 |
| 60 | EWS_26573619_Chip-Seq_HEK293_Human | 1.36324012 |
| 61 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34909036 |
| 62 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.33363663 |
| 63 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.31710063 |
| 64 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.30285912 |
| 65 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.29377945 |
| 66 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.28115709 |
| 67 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.26045994 |
| 68 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.25991621 |
| 69 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.22328896 |
| 70 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.21564791 |
| 71 | FUS_26573619_Chip-Seq_HEK293_Human | 1.19214933 |
| 72 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.18130143 |
| 73 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.12750332 |
| 74 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.12417783 |
| 75 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.10051749 |
| 76 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.09540994 |
| 77 | VDR_22108803_ChIP-Seq_LS180_Human | 1.07005124 |
| 78 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.04681286 |
| 79 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.04062452 |
| 80 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.03050793 |
| 81 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.01533591 |
| 82 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.00984031 |
| 83 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.99961187 |
| 84 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.99593388 |
| 85 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.97196349 |
| 86 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.95775543 |
| 87 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.95618304 |
| 88 | * SPI1_23547873_ChIP-Seq_NB4_Human | 0.95579627 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94361114 |
| 90 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.87017771 |
| 91 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.86886948 |
| 92 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83175778 |
| 93 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.82308705 |
| 94 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.78512360 |
| 95 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.78242276 |
| 96 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.76294054 |
| 97 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.74887243 |
| 98 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.74136626 |
| 99 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.74099385 |
| 100 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.74017241 |
| 101 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.73471732 |
| 102 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.72866998 |
| 103 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.71004923 |
| 104 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.70171974 |
| 105 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.70057778 |
| 106 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.68630490 |
| 107 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.68380951 |
| 108 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.67747267 |
| 109 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.66427060 |
| 110 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.66249868 |
| 111 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.66071501 |
| 112 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.64910417 |
| 113 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.62420617 |
| 114 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.62216020 |
| 115 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.61324830 |
| 116 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.60671418 |
| 117 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.59999465 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.42740338 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.42021078 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.00348819 |
| 4 | MP0008057_abnormal_DNA_replication | 3.90729829 |
| 5 | MP0008058_abnormal_DNA_repair | 3.75411092 |
| 6 | MP0003077_abnormal_cell_cycle | 3.56316169 |
| 7 | MP0003111_abnormal_nucleus_morphology | 3.39067967 |
| 8 | MP0006292_abnormal_olfactory_placode | 3.11676493 |
| 9 | MP0009379_abnormal_foot_pigmentation | 3.07912200 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.76022872 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.69036249 |
| 12 | MP0008877_abnormal_DNA_methylation | 2.34406837 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.25477051 |
| 14 | MP0003786_premature_aging | 2.21324077 |
| 15 | MP0003718_maternal_effect | 2.05388675 |
| 16 | MP0003123_paternal_imprinting | 2.04804359 |
| 17 | MP0009697_abnormal_copulation | 1.89875423 |
| 18 | MP0003186_abnormal_redox_activity | 1.87873393 |
| 19 | MP0003806_abnormal_nucleotide_metabolis | 1.83744248 |
| 20 | MP0006036_abnormal_mitochondrial_physio | 1.71592013 |
| 21 | MP0002938_white_spotting | 1.61206566 |
| 22 | MP0003315_abnormal_perineum_morphology | 1.58911452 |
| 23 | MP0000490_abnormal_crypts_of | 1.57472928 |
| 24 | MP0000372_irregular_coat_pigmentation | 1.47178879 |
| 25 | MP0005075_abnormal_melanosome_morpholog | 1.45237041 |
| 26 | MP0000350_abnormal_cell_proliferation | 1.44871838 |
| 27 | MP0008995_early_reproductive_senescence | 1.42666052 |
| 28 | MP0001986_abnormal_taste_sensitivity | 1.39652631 |
| 29 | MP0002736_abnormal_nociception_after | 1.39555596 |
| 30 | MP0002638_abnormal_pupillary_reflex | 1.39486364 |
| 31 | MP0000566_synostosis | 1.35379224 |
| 32 | MP0000313_abnormal_cell_death | 1.34691275 |
| 33 | MP0003763_abnormal_thymus_physiology | 1.32236229 |
| 34 | MP0003567_abnormal_fetal_cardiomyocyte | 1.31941819 |
| 35 | MP0001730_embryonic_growth_arrest | 1.30716450 |
| 36 | MP0003121_genomic_imprinting | 1.30040611 |
| 37 | MP0002132_abnormal_respiratory_system | 1.29484279 |
| 38 | MP0002095_abnormal_skin_pigmentation | 1.28636940 |
| 39 | MP0005084_abnormal_gallbladder_morpholo | 1.24522854 |
| 40 | MP0004133_heterotaxia | 1.24266018 |
| 41 | MP0005174_abnormal_tail_pigmentation | 1.20995521 |
| 42 | MP0006035_abnormal_mitochondrial_morpho | 1.20840563 |
| 43 | MP0003136_yellow_coat_color | 1.19714879 |
| 44 | MP0001188_hyperpigmentation | 1.19522866 |
| 45 | MP0001764_abnormal_homeostasis | 1.19164440 |
| 46 | MP0002210_abnormal_sex_determination | 1.16396345 |
| 47 | MP0002837_dystrophic_cardiac_calcinosis | 1.13018479 |
| 48 | MP0002277_abnormal_respiratory_mucosa | 1.12892855 |
| 49 | MP0002163_abnormal_gland_morphology | 1.11402770 |
| 50 | MP0002160_abnormal_reproductive_system | 1.09157817 |
| 51 | MP0005394_taste/olfaction_phenotype | 1.08837909 |
| 52 | MP0005499_abnormal_olfactory_system | 1.08837909 |
| 53 | MP0003890_abnormal_embryonic-extraembry | 1.08116350 |
| 54 | MP0001697_abnormal_embryo_size | 1.07185885 |
| 55 | MP0002009_preneoplasia | 1.06285821 |
| 56 | MP0000631_abnormal_neuroendocrine_gland | 1.05213757 |
| 57 | MP0009333_abnormal_splenocyte_physiolog | 1.04108283 |
| 58 | MP0002697_abnormal_eye_size | 1.04083601 |
| 59 | MP0003011_delayed_dark_adaptation | 1.04081050 |
| 60 | MP0002019_abnormal_tumor_incidence | 1.03555435 |
| 61 | MP0004808_abnormal_hematopoietic_stem | 1.02006761 |
| 62 | MP0008789_abnormal_olfactory_epithelium | 1.01381128 |
| 63 | MP0001835_abnormal_antigen_presentation | 1.01070877 |
| 64 | MP0005389_reproductive_system_phenotype | 1.01054604 |
| 65 | MP0003941_abnormal_skin_development | 1.00960848 |
| 66 | MP0005379_endocrine/exocrine_gland_phen | 0.98974347 |
| 67 | MP0001145_abnormal_male_reproductive | 0.98461557 |
| 68 | MP0002080_prenatal_lethality | 0.98093791 |
| 69 | MP0010030_abnormal_orbit_morphology | 0.97585036 |
| 70 | MP0001293_anophthalmia | 0.97309523 |
| 71 | MP0005671_abnormal_response_to | 0.96114731 |
| 72 | MP0005253_abnormal_eye_physiology | 0.95800462 |
| 73 | MP0002234_abnormal_pharynx_morphology | 0.95585360 |
| 74 | MP0002233_abnormal_nose_morphology | 0.94891464 |
| 75 | MP0001529_abnormal_vocalization | 0.94317827 |
| 76 | MP0001853_heart_inflammation | 0.94159562 |
| 77 | MP0002751_abnormal_autonomic_nervous | 0.93978565 |
| 78 | MP0000703_abnormal_thymus_morphology | 0.93087454 |
| 79 | MP0001984_abnormal_olfaction | 0.91891722 |
| 80 | MP0002006_tumorigenesis | 0.91266292 |
| 81 | MP0000049_abnormal_middle_ear | 0.90705299 |
| 82 | MP0001672_abnormal_embryogenesis/_devel | 0.90211296 |
| 83 | MP0005380_embryogenesis_phenotype | 0.90211296 |
| 84 | MP0001119_abnormal_female_reproductive | 0.88180858 |
| 85 | MP0000689_abnormal_spleen_morphology | 0.87823703 |
| 86 | MP0000653_abnormal_sex_gland | 0.87484061 |
| 87 | MP0004142_abnormal_muscle_tone | 0.87409416 |
| 88 | MP0000647_abnormal_sebaceous_gland | 0.86993880 |
| 89 | MP0002398_abnormal_bone_marrow | 0.86855835 |
| 90 | MP0002085_abnormal_embryonic_tissue | 0.85988768 |
| 91 | MP0000015_abnormal_ear_pigmentation | 0.85951527 |
| 92 | MP0002722_abnormal_immune_system | 0.85799912 |
| 93 | MP0002111_abnormal_tail_morphology | 0.85591582 |
| 94 | MP0001485_abnormal_pinna_reflex | 0.83786805 |
| 95 | MP0001929_abnormal_gametogenesis | 0.82877965 |
| 96 | MP0002102_abnormal_ear_morphology | 0.82359083 |
| 97 | MP0005408_hypopigmentation | 0.80550994 |
| 98 | MP0009672_abnormal_birth_weight | 0.80150045 |
| 99 | MP0003938_abnormal_ear_development | 0.79997326 |
| 100 | MP0003119_abnormal_digestive_system | 0.79346804 |
| 101 | MP0006072_abnormal_retinal_apoptosis | 0.78645157 |
| 102 | MP0002090_abnormal_vision | 0.78613484 |
| 103 | MP0009785_altered_susceptibility_to | 0.78514173 |
| 104 | MP0001919_abnormal_reproductive_system | 0.77274585 |
| 105 | MP0002148_abnormal_hypersensitivity_rea | 0.76364781 |
| 106 | MP0003984_embryonic_growth_retardation | 0.75235864 |
| 107 | MP0005391_vision/eye_phenotype | 0.74795608 |
| 108 | MP0000678_abnormal_parathyroid_gland | 0.73893928 |
| 109 | MP0002429_abnormal_blood_cell | 0.73260755 |
| 110 | MP0003787_abnormal_imprinting | 0.72417127 |
| 111 | MP0005266_abnormal_metabolism | 0.72179453 |
| 112 | MP0002088_abnormal_embryonic_growth/wei | 0.71673310 |
| 113 | MP0000358_abnormal_cell_content/ | 0.70445042 |
| 114 | MP0008872_abnormal_physiological_respon | 0.69672378 |
| 115 | MP0001186_pigmentation_phenotype | 0.67402292 |
| 116 | MP0005551_abnormal_eye_electrophysiolog | 0.67381527 |
| 117 | MP0003698_abnormal_male_reproductive | 0.67349236 |
| 118 | MP0000716_abnormal_immune_system | 0.66555838 |
| 119 | MP0005332_abnormal_amino_acid | 0.65104859 |
| 120 | MP0001286_abnormal_eye_development | 0.64968014 |
| 121 | MP0002282_abnormal_trachea_morphology | 0.63496605 |
| 122 | MP0001968_abnormal_touch/_nociception | 0.63453307 |
| 123 | MP0006276_abnormal_autonomic_nervous | 0.63326983 |
| 124 | MP0001905_abnormal_dopamine_level | 0.62995473 |
| 125 | MP0005395_other_phenotype | 0.62483446 |
| 126 | MP0004215_abnormal_myocardial_fiber | 0.60983043 |
| 127 | MP0004147_increased_porphyrin_level | 0.58496470 |
| 128 | MP0001800_abnormal_humoral_immune | 0.57646499 |
| 129 | MP0003937_abnormal_limbs/digits/tail_de | 0.56846611 |
| 130 | MP0002420_abnormal_adaptive_immunity | 0.56131653 |
| 131 | MP0002084_abnormal_developmental_patter | 0.56128655 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 4.80545706 |
| 2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.74442652 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 4.48724653 |
| 4 | Abnormal number of erythroid precursors (HP:0012131) | 4.43196630 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.14436081 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.05106500 |
| 7 | Birth length less than 3rd percentile (HP:0003561) | 3.98384942 |
| 8 | Hepatocellular necrosis (HP:0001404) | 3.93331414 |
| 9 | Increased CSF lactate (HP:0002490) | 3.84551582 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.67186225 |
| 11 | Hepatic necrosis (HP:0002605) | 3.59815279 |
| 12 | Progressive macrocephaly (HP:0004481) | 3.57592074 |
| 13 | Aplastic anemia (HP:0001915) | 3.56440914 |
| 14 | Macrocytic anemia (HP:0001972) | 3.54894758 |
| 15 | Acute encephalopathy (HP:0006846) | 3.54626131 |
| 16 | 3-Methylglutaconic aciduria (HP:0003535) | 3.51444677 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.42034389 |
| 18 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.42034389 |
| 19 | Microvesicular hepatic steatosis (HP:0001414) | 3.32358135 |
| 20 | Lipid accumulation in hepatocytes (HP:0006561) | 3.29889540 |
| 21 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.29320464 |
| 22 | Chromsome breakage (HP:0040012) | 3.25414602 |
| 23 | Type I transferrin isoform profile (HP:0003642) | 3.25061742 |
| 24 | Pallor (HP:0000980) | 3.24842038 |
| 25 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.21600981 |
| 26 | Increased serum lactate (HP:0002151) | 3.18754897 |
| 27 | Oral leukoplakia (HP:0002745) | 3.11233086 |
| 28 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.92254220 |
| 29 | Renal Fanconi syndrome (HP:0001994) | 2.88776691 |
| 30 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.81929663 |
| 31 | Exercise intolerance (HP:0003546) | 2.81205228 |
| 32 | Exertional dyspnea (HP:0002875) | 2.80419238 |
| 33 | Breast hypoplasia (HP:0003187) | 2.79206967 |
| 34 | Colon cancer (HP:0003003) | 2.69816658 |
| 35 | Abnormality of chromosome stability (HP:0003220) | 2.67103980 |
| 36 | Lactic acidosis (HP:0003128) | 2.61186421 |
| 37 | Abnormality of the preputium (HP:0100587) | 2.59001629 |
| 38 | Abnormality of the labia minora (HP:0012880) | 2.56225589 |
| 39 | 11 pairs of ribs (HP:0000878) | 2.50722679 |
| 40 | Meckel diverticulum (HP:0002245) | 2.49274718 |
| 41 | Rough bone trabeculation (HP:0100670) | 2.47496626 |
| 42 | Abnormality of methionine metabolism (HP:0010901) | 2.47237940 |
| 43 | Congenital, generalized hypertrichosis (HP:0004540) | 2.46221431 |
| 44 | Methylmalonic acidemia (HP:0002912) | 2.43618933 |
| 45 | Cerebral edema (HP:0002181) | 2.43533374 |
| 46 | Cerebral hypomyelination (HP:0006808) | 2.41552190 |
| 47 | Increased intramyocellular lipid droplets (HP:0012240) | 2.41049424 |
| 48 | Respiratory failure (HP:0002878) | 2.40122807 |
| 49 | Degeneration of anterior horn cells (HP:0002398) | 2.38454157 |
| 50 | Abnormality of the anterior horn cell (HP:0006802) | 2.38454157 |
| 51 | Reduced antithrombin III activity (HP:0001976) | 2.38388487 |
| 52 | Pancytopenia (HP:0001876) | 2.37303122 |
| 53 | Abnormality of the ileum (HP:0001549) | 2.36391757 |
| 54 | Patellar aplasia (HP:0006443) | 2.36381239 |
| 55 | Respiratory difficulties (HP:0002880) | 2.35131929 |
| 56 | Premature graying of hair (HP:0002216) | 2.34961205 |
| 57 | Absent thumb (HP:0009777) | 2.34163513 |
| 58 | Lethargy (HP:0001254) | 2.33171362 |
| 59 | Abnormal protein glycosylation (HP:0012346) | 2.25818588 |
| 60 | Abnormal glycosylation (HP:0012345) | 2.25818588 |
| 61 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.25818588 |
| 62 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.25818588 |
| 63 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.22446607 |
| 64 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.21059657 |
| 65 | Septo-optic dysplasia (HP:0100842) | 2.19147426 |
| 66 | Methylmalonic aciduria (HP:0012120) | 2.17713141 |
| 67 | Myelodysplasia (HP:0002863) | 2.17333926 |
| 68 | Abnormality of serum amino acid levels (HP:0003112) | 2.17149622 |
| 69 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.14499509 |
| 70 | Abnormality of alanine metabolism (HP:0010916) | 2.14499509 |
| 71 | Hyperalaninemia (HP:0003348) | 2.14499509 |
| 72 | Abnormal lung lobation (HP:0002101) | 2.13376210 |
| 73 | Bone marrow hypocellularity (HP:0005528) | 2.13287858 |
| 74 | Triphalangeal thumb (HP:0001199) | 2.10744070 |
| 75 | Pancreatic cysts (HP:0001737) | 2.09293029 |
| 76 | IgM deficiency (HP:0002850) | 2.08713824 |
| 77 | Hyperglycinemia (HP:0002154) | 2.05689946 |
| 78 | Increased serum pyruvate (HP:0003542) | 2.05068865 |
| 79 | Abnormality of glycolysis (HP:0004366) | 2.05068865 |
| 80 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.04428226 |
| 81 | Optic disc pallor (HP:0000543) | 2.03750806 |
| 82 | Supernumerary spleens (HP:0009799) | 2.01557260 |
| 83 | Megaloblastic anemia (HP:0001889) | 2.01139795 |
| 84 | Stenosis of the external auditory canal (HP:0000402) | 2.00581364 |
| 85 | X-linked dominant inheritance (HP:0001423) | 1.98584515 |
| 86 | Abnormality of the renal collecting system (HP:0004742) | 1.95229597 |
| 87 | Increased muscle lipid content (HP:0009058) | 1.95007493 |
| 88 | Cellular immunodeficiency (HP:0005374) | 1.94256514 |
| 89 | Multiple enchondromatosis (HP:0005701) | 1.93980558 |
| 90 | Type 2 muscle fiber atrophy (HP:0003554) | 1.93576940 |
| 91 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.93017157 |
| 92 | Thrombocytosis (HP:0001894) | 1.92811528 |
| 93 | Cleft eyelid (HP:0000625) | 1.92170179 |
| 94 | Pancreatic fibrosis (HP:0100732) | 1.90813725 |
| 95 | Selective tooth agenesis (HP:0001592) | 1.90547193 |
| 96 | Carpal bone hypoplasia (HP:0001498) | 1.90052902 |
| 97 | Abnormal trabecular bone morphology (HP:0100671) | 1.89948598 |
| 98 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.89476518 |
| 99 | Duplicated collecting system (HP:0000081) | 1.88674964 |
| 100 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.87219869 |
| 101 | Leukodystrophy (HP:0002415) | 1.87219827 |
| 102 | Horseshoe kidney (HP:0000085) | 1.86745714 |
| 103 | Hypoplasia of the radius (HP:0002984) | 1.86473972 |
| 104 | CNS demyelination (HP:0007305) | 1.85401736 |
| 105 | Small intestinal stenosis (HP:0012848) | 1.84611949 |
| 106 | Duodenal stenosis (HP:0100867) | 1.84611949 |
| 107 | Absent radius (HP:0003974) | 1.84343631 |
| 108 | Glycosuria (HP:0003076) | 1.84162554 |
| 109 | Abnormality of urine glucose concentration (HP:0011016) | 1.84162554 |
| 110 | Muscle fiber atrophy (HP:0100295) | 1.83366791 |
| 111 | Amniotic constriction ring (HP:0009775) | 1.81129511 |
| 112 | Abnormality of placental membranes (HP:0011409) | 1.81129511 |
| 113 | Facial cleft (HP:0002006) | 1.80220161 |
| 114 | Generalized aminoaciduria (HP:0002909) | 1.79161962 |
| 115 | Sparse eyelashes (HP:0000653) | 1.79106514 |
| 116 | Molar tooth sign on MRI (HP:0002419) | 1.78578367 |
| 117 | Abnormality of midbrain morphology (HP:0002418) | 1.78578367 |
| 118 | Absent septum pellucidum (HP:0001331) | 1.77577298 |
| 119 | Absent forearm bone (HP:0003953) | 1.75587902 |
| 120 | Aplasia involving forearm bones (HP:0009822) | 1.75587902 |
| 121 | True hermaphroditism (HP:0010459) | 1.74361887 |
| 122 | Lymphoma (HP:0002665) | 1.74318436 |
| 123 | Medulloblastoma (HP:0002885) | 1.74102930 |
| 124 | Trismus (HP:0000211) | 1.73703076 |
| 125 | Sclerocornea (HP:0000647) | 1.73476022 |
| 126 | Abnormality of renal resorption (HP:0011038) | 1.73176117 |
| 127 | Hypoplasia of the pons (HP:0012110) | 1.72924768 |
| 128 | Abnormality of the pons (HP:0007361) | 1.72383160 |
| 129 | Hyperphosphaturia (HP:0003109) | 1.71419296 |
| 130 | Homocystinuria (HP:0002156) | 1.68858930 |
| 131 | Abnormality of homocysteine metabolism (HP:0010919) | 1.68858930 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.69734969 |
| 2 | BUB1 | 3.98568974 |
| 3 | EIF2AK1 | 3.82732514 |
| 4 | WEE1 | 3.67704710 |
| 5 | STK16 | 3.62237852 |
| 6 | SRPK1 | 3.20495634 |
| 7 | EIF2AK3 | 3.02822555 |
| 8 | NME2 | 2.88359902 |
| 9 | CDC7 | 2.73308744 |
| 10 | PLK4 | 2.61950909 |
| 11 | VRK1 | 2.39201491 |
| 12 | MKNK1 | 2.38810924 |
| 13 | ACVR1B | 2.30309732 |
| 14 | TAF1 | 1.94543751 |
| 15 | MKNK2 | 1.91403574 |
| 16 | ZAK | 1.87323055 |
| 17 | MST4 | 1.85164589 |
| 18 | PBK | 1.85004631 |
| 19 | TLK1 | 1.80616057 |
| 20 | BRSK2 | 1.80044282 |
| 21 | TTK | 1.56472418 |
| 22 | TEC | 1.54753885 |
| 23 | PLK1 | 1.52076378 |
| 24 | TRIM28 | 1.50304297 |
| 25 | IRAK3 | 1.48578057 |
| 26 | WNK3 | 1.46461031 |
| 27 | TNIK | 1.43887329 |
| 28 | NUAK1 | 1.42556420 |
| 29 | ATR | 1.40286770 |
| 30 | PASK | 1.37782572 |
| 31 | EIF2AK2 | 1.36401775 |
| 32 | AURKB | 1.36312853 |
| 33 | CDK8 | 1.35427672 |
| 34 | PLK3 | 1.35407134 |
| 35 | PDK2 | 1.33491632 |
| 36 | CDK7 | 1.31670215 |
| 37 | DYRK3 | 1.28770922 |
| 38 | NME1 | 1.27133556 |
| 39 | NEK2 | 1.26841316 |
| 40 | MAP4K2 | 1.25571919 |
| 41 | CCNB1 | 1.24285005 |
| 42 | IRAK4 | 1.23148212 |
| 43 | TSSK6 | 1.21289525 |
| 44 | RPS6KB2 | 1.18787344 |
| 45 | STK38L | 1.16149208 |
| 46 | NEK1 | 1.14475638 |
| 47 | RPS6KA4 | 1.03357830 |
| 48 | FLT3 | 0.97553933 |
| 49 | CSNK1G1 | 0.95991881 |
| 50 | MUSK | 0.95794171 |
| 51 | AURKA | 0.92728990 |
| 52 | BCKDK | 0.89679857 |
| 53 | CSNK2A1 | 0.87888735 |
| 54 | BRSK1 | 0.84589717 |
| 55 | PIM2 | 0.83460378 |
| 56 | CSNK1G2 | 0.81644857 |
| 57 | CHEK2 | 0.81053690 |
| 58 | KDR | 0.80956849 |
| 59 | CSNK2A2 | 0.77388984 |
| 60 | YES1 | 0.75938270 |
| 61 | ADRBK2 | 0.74650914 |
| 62 | PNCK | 0.74127463 |
| 63 | NEK6 | 0.73968383 |
| 64 | TXK | 0.72433986 |
| 65 | EPHA2 | 0.72256132 |
| 66 | RPS6KA5 | 0.71985312 |
| 67 | TGFBR1 | 0.71246663 |
| 68 | CSNK1A1L | 0.70203733 |
| 69 | BCR | 0.70077059 |
| 70 | BRAF | 0.69044419 |
| 71 | STK4 | 0.68334910 |
| 72 | MYLK | 0.68165875 |
| 73 | BRD4 | 0.67454553 |
| 74 | DYRK2 | 0.65581879 |
| 75 | OXSR1 | 0.65006263 |
| 76 | ILK | 0.64041502 |
| 77 | TESK2 | 0.63070200 |
| 78 | MAP2K7 | 0.62616967 |
| 79 | * CHEK1 | 0.62181739 |
| 80 | CDK19 | 0.61907341 |
| 81 | INSRR | 0.61903999 |
| 82 | GRK1 | 0.60236829 |
| 83 | PRKCI | 0.60194602 |
| 84 | BMPR1B | 0.59646726 |
| 85 | NLK | 0.58376050 |
| 86 | PLK2 | 0.56645665 |
| 87 | DAPK1 | 0.56255502 |
| 88 | ATM | 0.55893926 |
| 89 | ALK | 0.54896431 |
| 90 | MAP3K12 | 0.54596566 |
| 91 | PIK3CA | 0.53898913 |
| 92 | CDK4 | 0.52860571 |
| 93 | BTK | 0.52373724 |
| 94 | CSNK1E | 0.50597831 |
| 95 | CAMKK2 | 0.50128001 |
| 96 | ERBB3 | 0.49393880 |
| 97 | MAPKAPK5 | 0.49393313 |
| 98 | MAP3K4 | 0.48762377 |
| 99 | STK39 | 0.48549501 |
| 100 | WNK4 | 0.45422973 |
| 101 | KIT | 0.45281700 |
| 102 | PAK4 | 0.44267635 |
| 103 | PIM1 | 0.44079317 |
| 104 | CDK2 | 0.43598918 |
| 105 | MAP3K8 | 0.43556329 |
| 106 | OBSCN | 0.42995495 |
| 107 | CASK | 0.40608231 |
| 108 | BMPR2 | 0.39154777 |
| 109 | LYN | 0.38328383 |
| 110 | CDK3 | 0.38256476 |
| 111 | GRK7 | 0.36759042 |
| 112 | PRKCG | 0.36686746 |
| 113 | CDK1 | 0.35870434 |
| 114 | AKT3 | 0.35127367 |
| 115 | ERBB4 | 0.34204252 |
| 116 | IKBKB | 0.32796737 |
| 117 | STK3 | 0.32474532 |
| 118 | DAPK3 | 0.32149444 |
| 119 | IRAK1 | 0.32058031 |
| 120 | FGFR1 | 0.31146794 |
| 121 | STK24 | 0.30628674 |
| 122 | PAK1 | 0.30535687 |
| 123 | CSNK1A1 | 0.28816285 |
| 124 | ABL2 | 0.27675736 |
| 125 | MARK3 | 0.27395066 |
| 126 | CSNK1G3 | 0.27034101 |
| 127 | MELK | 0.26396283 |
| 128 | RPS6KB1 | 0.25772442 |
| 129 | LIMK1 | 0.25606781 |
| 130 | RAF1 | 0.24811115 |
| 131 | IRAK2 | 0.24432602 |
| 132 | PRKDC | 0.24071570 |
| 133 | PRKACB | 0.21099934 |
| 134 | CLK1 | 0.20545383 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.82228443 |
| 2 | * DNA replication_Homo sapiens_hsa03030 | 4.08894308 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 4.07911437 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.85594245 |
| 5 | * Mismatch repair_Homo sapiens_hsa03430 | 3.53218182 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.12231540 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.06651609 |
| 8 | * Homologous recombination_Homo sapiens_hsa03440 | 2.78774738 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.78286737 |
| 10 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.77295691 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.55782534 |
| 12 | Protein export_Homo sapiens_hsa03060 | 2.53201017 |
| 13 | Base excision repair_Homo sapiens_hsa03410 | 2.46823908 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 2.39839265 |
| 15 | Parkinsons disease_Homo sapiens_hsa05012 | 2.39284392 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.20965158 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.10130000 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 2.03587517 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.99005475 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.96980106 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.95790914 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.92247807 |
| 23 | Cell cycle_Homo sapiens_hsa04110 | 1.87209696 |
| 24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.61125048 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.55651099 |
| 26 | Alzheimers disease_Homo sapiens_hsa05010 | 1.47494448 |
| 27 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.38101120 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.36202067 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.33857413 |
| 30 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.26109480 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.18394251 |
| 32 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.09225237 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.07208167 |
| 34 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.04592133 |
| 35 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.03693941 |
| 36 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.98725330 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.97855593 |
| 38 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.96330599 |
| 39 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.84539490 |
| 40 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.84533121 |
| 41 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.83832047 |
| 42 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.79739230 |
| 43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.77779923 |
| 44 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.75499779 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.74673837 |
| 46 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.71016031 |
| 47 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.69211626 |
| 48 | Sulfur relay system_Homo sapiens_hsa04122 | 0.67905264 |
| 49 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.65164358 |
| 50 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.64679205 |
| 51 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.64614146 |
| 52 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.64022254 |
| 53 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.63442896 |
| 54 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.62292185 |
| 55 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60796392 |
| 56 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.58993337 |
| 57 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.58498127 |
| 58 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.58151441 |
| 59 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.56961598 |
| 60 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.56534091 |
| 61 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.54505791 |
| 62 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.50768480 |
| 63 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.49465598 |
| 64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.48227573 |
| 65 | Allograft rejection_Homo sapiens_hsa05330 | 0.46607187 |
| 66 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.45615128 |
| 67 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.45391314 |
| 68 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.43054844 |
| 69 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.41573084 |
| 70 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.38922645 |
| 71 | Asthma_Homo sapiens_hsa05310 | 0.38698803 |
| 72 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.38016041 |
| 73 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.36628067 |
| 74 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.32850036 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.32433321 |
| 76 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.32145130 |
| 77 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.31121911 |
| 78 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.30848577 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.30685187 |
| 80 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.30464917 |
| 81 | Legionellosis_Homo sapiens_hsa05134 | 0.29871459 |
| 82 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.29677783 |
| 83 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.29500211 |
| 84 | Carbon metabolism_Homo sapiens_hsa01200 | 0.29001653 |
| 85 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.28616859 |
| 86 | Retinol metabolism_Homo sapiens_hsa00830 | 0.28103990 |
| 87 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.27922174 |
| 88 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.27489633 |
| 89 | Thyroid cancer_Homo sapiens_hsa05216 | 0.27223328 |
| 90 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.27106412 |
| 91 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.26956426 |
| 92 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.26114132 |
| 93 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.26048317 |
| 94 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.25894630 |
| 95 | Measles_Homo sapiens_hsa05162 | 0.24702148 |
| 96 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.24625168 |
| 97 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.23753444 |
| 98 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.23664835 |
| 99 | Galactose metabolism_Homo sapiens_hsa00052 | 0.23535784 |
| 100 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.23278921 |
| 101 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.23019075 |
| 102 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.22896588 |
| 103 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.22857981 |
| 104 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.22774719 |
| 105 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.21686648 |
| 106 | HTLV-I infection_Homo sapiens_hsa05166 | 0.21525513 |
| 107 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.19256113 |
| 108 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.19111583 |
| 109 | Alcoholism_Homo sapiens_hsa05034 | 0.18756737 |
| 110 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.17994841 |
| 111 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.17058976 |
| 112 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.16730688 |
| 113 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.15402879 |
| 114 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.14866665 |
| 115 | Phototransduction_Homo sapiens_hsa04744 | 0.14440491 |
| 116 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.14339777 |
| 117 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.13992461 |
| 118 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.13498871 |
| 119 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.12980451 |
| 120 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.12907164 |
| 121 | Other glycan degradation_Homo sapiens_hsa00511 | 0.10350052 |
| 122 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.10316046 |
| 123 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.08633597 |
| 124 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.08495618 |
| 125 | Olfactory transduction_Homo sapiens_hsa04740 | 0.07126387 |
| 126 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.06077795 |
| 127 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.05726407 |
| 128 | Peroxisome_Homo sapiens_hsa04146 | 0.04414141 |
| 129 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.04202595 |
| 130 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.03718552 |
| 131 | Apoptosis_Homo sapiens_hsa04210 | 0.03426017 |

