SSC4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)5.14725013
2plasma lipoprotein particle assembly (GO:0034377)5.14649009
3proline biosynthetic process (GO:0006561)4.90254532
4negative regulation of fibrinolysis (GO:0051918)4.64361322
5regulation of apoptotic cell clearance (GO:2000425)4.63655687
6proline metabolic process (GO:0006560)4.59865567
7mitotic metaphase plate congression (GO:0007080)4.54823091
8DNA replication checkpoint (GO:0000076)4.49198975
9protein-lipid complex assembly (GO:0065005)4.42576399
10regulation of cholesterol esterification (GO:0010872)4.40714174
11intestinal cholesterol absorption (GO:0030299)4.25805905
12low-density lipoprotein particle remodeling (GO:0034374)4.20479401
13protein carboxylation (GO:0018214)4.17152620
14peptidyl-glutamic acid carboxylation (GO:0017187)4.17152620
15folic acid metabolic process (GO:0046655)4.10713871
16purine nucleobase biosynthetic process (GO:0009113)4.01261698
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.99597839
18L-phenylalanine metabolic process (GO:0006558)3.99597839
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.99501591
20L-phenylalanine catabolic process (GO:0006559)3.99501591
21DNA deamination (GO:0045006)3.98324603
22folic acid-containing compound biosynthetic process (GO:0009396)3.96505820
23regulation of fibrinolysis (GO:0051917)3.96037485
24regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.88920011
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.87790166
26ribosome assembly (GO:0042255)3.84461920
27protein-lipid complex remodeling (GO:0034368)3.84079178
28macromolecular complex remodeling (GO:0034367)3.84079178
29plasma lipoprotein particle remodeling (GO:0034369)3.84079178
30L-serine metabolic process (GO:0006563)3.83601105
31regulation of spindle organization (GO:0090224)3.77267375
32protein localization to kinetochore (GO:0034501)3.76291063
33nucleobase biosynthetic process (GO:0046112)3.75448761
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.72423333
35plasma lipoprotein particle clearance (GO:0034381)3.70433290
36cholesterol efflux (GO:0033344)3.67712835
37DNA replication initiation (GO:0006270)3.66894834
38plasma lipoprotein particle organization (GO:0071827)3.66815669
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.61829872
40metaphase plate congression (GO:0051310)3.59047627
41regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.56715854
42regulation of posttranscriptional gene silencing (GO:0060147)3.56628869
43regulation of gene silencing by miRNA (GO:0060964)3.56628869
44regulation of gene silencing by RNA (GO:0060966)3.56628869
45formation of translation preinitiation complex (GO:0001731)3.51583317
46high-density lipoprotein particle remodeling (GO:0034375)3.49350228
47paraxial mesoderm development (GO:0048339)3.48968533
48DNA strand elongation involved in DNA replication (GO:0006271)3.48035001
49regulation of protein activation cascade (GO:2000257)3.41509748
50protein-lipid complex subunit organization (GO:0071825)3.36462933
51glycine metabolic process (GO:0006544)3.36300983
52regulation of complement activation (GO:0030449)3.33136533
53protein localization to chromosome, centromeric region (GO:0071459)3.32241073
54blood coagulation, intrinsic pathway (GO:0007597)3.31938900
55rRNA modification (GO:0000154)3.28735687
56DNA strand elongation (GO:0022616)3.28199875
57telomere maintenance via semi-conservative replication (GO:0032201)3.27404418
58protein K6-linked ubiquitination (GO:0085020)3.26871473
59reverse cholesterol transport (GO:0043691)3.23629519
60regulation of plasminogen activation (GO:0010755)3.22739610
61regulation of cholesterol homeostasis (GO:2000188)3.21921006
62regulation of cholesterol biosynthetic process (GO:0045540)3.21355983
63regulation of non-canonical Wnt signaling pathway (GO:2000050)3.21344504
64ribosome biogenesis (GO:0042254)3.20561909
65pteridine-containing compound biosynthetic process (GO:0042559)3.16381058
66mitotic chromosome condensation (GO:0007076)3.15029966
67L-alpha-amino acid transmembrane transport (GO:1902475)3.13827428
68positive regulation of chromosome segregation (GO:0051984)3.13491998
69notochord development (GO:0030903)3.12993458
70mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.11524152
71regulation of mitotic spindle organization (GO:0060236)3.11504913
72mitotic nuclear envelope disassembly (GO:0007077)3.09819891
73establishment of integrated proviral latency (GO:0075713)3.09383181
74establishment of chromosome localization (GO:0051303)3.08981273
75attachment of spindle microtubules to kinetochore (GO:0008608)3.08885492
76negative regulation of sterol transport (GO:0032372)3.08528421
77negative regulation of cholesterol transport (GO:0032375)3.08528421
78serine family amino acid biosynthetic process (GO:0009070)3.06837787
79ribosomal small subunit assembly (GO:0000028)3.05594693
80mitotic sister chromatid segregation (GO:0000070)3.04468933
81regulation of bile acid biosynthetic process (GO:0070857)3.04464189
82heterochromatin organization (GO:0070828)3.03834838
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01890099
84telomere maintenance via recombination (GO:0000722)3.00135558
85maturation of SSU-rRNA (GO:0030490)2.99386071
86L-methionine biosynthetic process (GO:0071265)2.97981974
87amino acid salvage (GO:0043102)2.97981974
88L-methionine salvage (GO:0071267)2.97981974
89positive regulation of hormone metabolic process (GO:0032352)2.94397446
90pentose metabolic process (GO:0019321)2.91954253
91intestinal absorption (GO:0050892)2.88900953
92ribonucleoprotein complex biogenesis (GO:0022613)2.88452468
93IMP biosynthetic process (GO:0006188)2.88274049
94regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.85944987
95membrane disassembly (GO:0030397)2.85438028
96nuclear envelope disassembly (GO:0051081)2.85438028
97IMP metabolic process (GO:0046040)2.84500552
98pinocytosis (GO:0006907)2.83696805
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.83688019
100positive regulation of hormone biosynthetic process (GO:0046886)2.82802032
101rRNA methylation (GO:0031167)2.82485649
102ribosomal small subunit biogenesis (GO:0042274)2.82478241
103lung epithelium development (GO:0060428)2.80927945
104regulation of mitochondrial translation (GO:0070129)2.79150338
105pseudouridine synthesis (GO:0001522)2.76932466
106protein retention in ER lumen (GO:0006621)2.75429105
107rRNA processing (GO:0006364)2.74350075
108monoubiquitinated protein deubiquitination (GO:0035520)2.74166382
1094-hydroxyproline metabolic process (GO:0019471)2.73003812
110translational initiation (GO:0006413)2.72658139
111L-ascorbic acid metabolic process (GO:0019852)2.72497061
112CENP-A containing nucleosome assembly (GO:0034080)2.72435017
113positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.70600416
114protein complex localization (GO:0031503)2.70566796
115regulation of chromosome segregation (GO:0051983)2.70470044
116phospholipid efflux (GO:0033700)2.69656949
117telomere maintenance via telomere lengthening (GO:0010833)2.68796989
118histone H2A ubiquitination (GO:0033522)2.68422213
119chromatin remodeling at centromere (GO:0031055)2.68121862
120low-density lipoprotein particle clearance (GO:0034383)2.67700059
121sterol homeostasis (GO:0055092)2.67520810
122kinetochore assembly (GO:0051382)2.67337240
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66716545
124DNA replication-dependent nucleosome organization (GO:0034723)2.66569656
125DNA replication-dependent nucleosome assembly (GO:0006335)2.66569656
126folic acid-containing compound metabolic process (GO:0006760)2.66478250
127viral transcription (GO:0019083)2.65931641
128cholesterol biosynthetic process (GO:0006695)2.65806520
129translational termination (GO:0006415)2.65693419
130pre-miRNA processing (GO:0031054)2.65677024
131rRNA metabolic process (GO:0016072)2.65393330
132cholesterol homeostasis (GO:0042632)2.65371381
133mitotic recombination (GO:0006312)2.65200451
134histone H2A monoubiquitination (GO:0035518)2.64448026
135inner cell mass cell proliferation (GO:0001833)2.61939123
136proteasome assembly (GO:0043248)2.61666752
137lysine metabolic process (GO:0006553)2.61329448
138lysine catabolic process (GO:0006554)2.61329448
139regulation of histone H3-K27 methylation (GO:0061085)2.60810892
140DNA replication-independent nucleosome assembly (GO:0006336)2.60157266
141DNA replication-independent nucleosome organization (GO:0034724)2.60157266
142histone arginine methylation (GO:0034969)2.59981651
143meiotic chromosome segregation (GO:0045132)2.59679243
144alpha-linolenic acid metabolic process (GO:0036109)2.59429803
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59107824
146regulation of translation in response to stress (GO:0043555)2.58133946
147spindle checkpoint (GO:0031577)2.57775322
148serine family amino acid catabolic process (GO:0009071)2.57611038
149mesenchymal cell proliferation (GO:0010463)2.55985356
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55137878
151trivalent inorganic anion homeostasis (GO:0072506)2.54913948
152phosphate ion homeostasis (GO:0055062)2.54913948
153negative regulation of chromosome segregation (GO:0051985)2.54907806
154methionine biosynthetic process (GO:0009086)2.54778666
155cellular modified amino acid catabolic process (GO:0042219)2.54560056
156mitochondrial DNA metabolic process (GO:0032042)2.52671771
157regulation of cell fate specification (GO:0042659)2.52570875
158positive regulation of lipoprotein lipase activity (GO:0051006)2.52236264
159positive regulation of triglyceride lipase activity (GO:0061365)2.52236264
160maturation of 5.8S rRNA (GO:0000460)2.51616583
161kinetochore organization (GO:0051383)2.51479874
162oocyte maturation (GO:0001556)2.50595159
163lung-associated mesenchyme development (GO:0060484)2.49789330
164methionine metabolic process (GO:0006555)2.49263535
165glutamate metabolic process (GO:0006536)2.48439952
166protein localization to chromosome (GO:0034502)2.48069389
167regulation of stem cell maintenance (GO:2000036)2.47302462
168ribosomal large subunit biogenesis (GO:0042273)2.46971645
169pteridine-containing compound metabolic process (GO:0042558)2.46906608
170translational elongation (GO:0006414)2.46780000
171modified amino acid transport (GO:0072337)2.45670175
172negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.45402367
173diacylglycerol metabolic process (GO:0046339)2.44936684
174sulfur amino acid biosynthetic process (GO:0000097)2.44796107
175dorsal/ventral axis specification (GO:0009950)2.44286748
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.44223860
177serine family amino acid metabolic process (GO:0009069)2.43457897
178sterol transport (GO:0015918)2.43360869
179cholesterol transport (GO:0030301)2.43360869
180negative regulation of mitotic sister chromatid separation (GO:2000816)2.43041819
181negative regulation of mitotic sister chromatid segregation (GO:0033048)2.43041819
182negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.43041819
183negative regulation of sister chromatid segregation (GO:0033046)2.43041819
184regulation of exit from mitosis (GO:0007096)2.42969675
185convergent extension (GO:0060026)2.42625493
186regulation of mitotic metaphase/anaphase transition (GO:0030071)2.42384869
187lipoprotein metabolic process (GO:0042157)2.42311371
188mitotic spindle assembly checkpoint (GO:0007094)2.42301411
189mitotic spindle checkpoint (GO:0071174)2.41799892
190folic acid transport (GO:0015884)2.40986756
191nucleotide-sugar biosynthetic process (GO:0009226)2.40528291
192biotin metabolic process (GO:0006768)2.39550755
193fatty acid homeostasis (GO:0055089)2.37635386
194peptidyl-arginine omega-N-methylation (GO:0035247)2.36421839
195glutamine family amino acid biosynthetic process (GO:0009084)2.35930476
196oligosaccharide catabolic process (GO:0009313)2.35848928
197branching involved in salivary gland morphogenesis (GO:0060445)2.35493071
198positive regulation of SMAD protein import into nucleus (GO:0060391)2.35400055

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21505256
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.77442018
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.34839556
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.00359522
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81582713
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46596199
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45904646
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.38639361
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37758272
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36554778
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29747721
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25592381
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.25137351
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.15899092
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15548766
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14029119
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.10047709
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10037551
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09752042
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09412620
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.05856470
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.99184828
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.98014597
24XRN2_22483619_ChIP-Seq_HELA_Human1.91142775
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91025513
26AR_21909140_ChIP-Seq_LNCAP_Human1.84557217
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84325861
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82730812
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80268358
30VDR_23849224_ChIP-Seq_CD4+_Human1.78963720
31SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.77294633
32MYC_22102868_ChIP-Seq_BL_Human1.76027071
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72062333
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71013476
35SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70478588
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69851032
37DCP1A_22483619_ChIP-Seq_HELA_Human1.68199890
38ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66231370
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65480550
40GABP_19822575_ChIP-Seq_HepG2_Human1.64550738
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62145337
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61111061
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60391049
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54898143
45NANOG_16153702_ChIP-ChIP_HESCs_Human1.53182106
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53136935
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51155670
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.50528202
49CLOCK_20551151_ChIP-Seq_293T_Human1.47658302
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46463104
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.45959779
52FOXP3_21729870_ChIP-Seq_TREG_Human1.45802507
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.45176595
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44708179
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44166080
56LXR_22158963_ChIP-Seq_LIVER_Mouse1.42609090
57SOX17_20123909_ChIP-Seq_XEN_Mouse1.41970364
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41702051
59KDM5A_27292631_Chip-Seq_BREAST_Human1.39535211
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39159110
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38530056
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36567718
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35280435
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.35119867
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34901177
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32474169
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32209620
68TTF2_22483619_ChIP-Seq_HELA_Human1.28579951
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27985970
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26933997
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26915095
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24476050
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23806452
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23794759
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22383853
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19881147
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19708880
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19577456
79TFEB_21752829_ChIP-Seq_HELA_Human1.18668748
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18642302
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17598542
82VDR_21846776_ChIP-Seq_THP-1_Human1.17213988
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16465669
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16349056
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16145166
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16105616
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15686348
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14959490
89SPI1_23547873_ChIP-Seq_NB4_Human1.14803524
90TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14020123
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13817189
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.12967149
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.12559036
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10878016
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09609548
96CIITA_25753668_ChIP-Seq_RAJI_Human1.09503549
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08425333
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08383907
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08106410
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06689263
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05793403
102SOX2_16153702_ChIP-ChIP_HESCs_Human1.05244198
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04793408
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04555791
105KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04538987
106KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04538987
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04538987
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03686609
109OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03457863
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03343617
111NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03340741
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03249032
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03078783
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02731484
115IRF8_21731497_ChIP-ChIP_J774_Mouse1.01937450
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01878121
117THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01496645
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00978907
119TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00853285
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00471986
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98730598
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98629708
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.97730429
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96866942
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96577380
126ELK1_19687146_ChIP-ChIP_HELA_Human0.95950791
127NANOG_21062744_ChIP-ChIP_HESCs_Human0.95914825
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94757226
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.92866723
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92197922
131MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92180652
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92074912
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91961460
134ZNF263_19887448_ChIP-Seq_K562_Human0.91164028
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90422580
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89144297
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88990270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.78069290
2MP0003122_maternal_imprinting4.60081564
3MP0003111_abnormal_nucleus_morphology3.48393080
4MP0000566_synostosis3.30661831
5MP0004957_abnormal_blastocyst_morpholog3.21705587
6MP0010094_abnormal_chromosome_stability3.19625924
7MP0003941_abnormal_skin_development3.18809731
8MP0003195_calcinosis3.01137598
9MP0009840_abnormal_foam_cell2.95269681
10MP0003077_abnormal_cell_cycle2.94145162
11MP0010030_abnormal_orbit_morphology2.90205249
12MP0003806_abnormal_nucleotide_metabolis2.86319103
13MP0002254_reproductive_system_inflammat2.79320705
14MP0006292_abnormal_olfactory_placode2.60431544
15MP0003718_maternal_effect2.42016470
16MP0002938_white_spotting2.22169609
17MP0003136_yellow_coat_color2.15105879
18MP0002089_abnormal_postnatal_growth/wei2.04732274
19MP0008057_abnormal_DNA_replication2.02786266
20MP0000490_abnormal_crypts_of1.97114177
21MP0001293_anophthalmia1.92307695
22MP0009333_abnormal_splenocyte_physiolog1.91930972
23MP0010307_abnormal_tumor_latency1.91865942
24MP0001666_abnormal_nutrient_absorption1.89345582
25MP0005451_abnormal_body_composition1.89231077
26MP0000350_abnormal_cell_proliferation1.83384089
27MP0003121_genomic_imprinting1.82329642
28MP0006054_spinal_hemorrhage1.78795476
29MP0010329_abnormal_lipoprotein_level1.76505806
30MP0001730_embryonic_growth_arrest1.76080374
31MP0004272_abnormal_basement_membrane1.71801086
32MP0008007_abnormal_cellular_replicative1.71733292
33MP0008058_abnormal_DNA_repair1.71624493
34MP0003937_abnormal_limbs/digits/tail_de1.69650040
35MP0003890_abnormal_embryonic-extraembry1.67981091
36MP0003436_decreased_susceptibility_to1.67171808
37MP0002396_abnormal_hematopoietic_system1.65928103
38MP0003123_paternal_imprinting1.65574604
39MP0008260_abnormal_autophagy1.63180215
40MP0002697_abnormal_eye_size1.61992758
41MP0001915_intracranial_hemorrhage1.61402904
42MP0002233_abnormal_nose_morphology1.61231345
43MP0005365_abnormal_bile_salt1.60183054
44MP0009672_abnormal_birth_weight1.58313585
45MP0001545_abnormal_hematopoietic_system1.58073976
46MP0005397_hematopoietic_system_phenotyp1.58073976
47MP0005360_urolithiasis1.56433557
48MP0003656_abnormal_erythrocyte_physiolo1.50274612
49MP0002653_abnormal_ependyma_morphology1.49380193
50MP0005076_abnormal_cell_differentiation1.49285419
51MP0003315_abnormal_perineum_morphology1.46993523
52MP0005085_abnormal_gallbladder_physiolo1.46765751
53MP0003186_abnormal_redox_activity1.46674338
54MP0002139_abnormal_hepatobiliary_system1.46359413
55MP0010352_gastrointestinal_tract_polyps1.42734668
56MP0003942_abnormal_urinary_system1.38897765
57MP0009278_abnormal_bone_marrow1.36992673
58MP0001286_abnormal_eye_development1.35410465
59MP0008932_abnormal_embryonic_tissue1.35328983
60MP0002019_abnormal_tumor_incidence1.33052905
61MP0005257_abnormal_intraocular_pressure1.32285568
62MP0005083_abnormal_biliary_tract1.29194668
63MP0001672_abnormal_embryogenesis/_devel1.29088167
64MP0005380_embryogenesis_phenotype1.29088167
65MP0004133_heterotaxia1.27445065
66MP0001661_extended_life_span1.25897002
67MP0002111_abnormal_tail_morphology1.25414981
68MP0003119_abnormal_digestive_system1.25085109
69MP0005379_endocrine/exocrine_gland_phen1.24162585
70MP0002092_abnormal_eye_morphology1.24160687
71MP0000537_abnormal_urethra_morphology1.23392417
72MP0001697_abnormal_embryo_size1.21182543
73MP0003172_abnormal_lysosome_physiology1.19192902
74MP0001849_ear_inflammation1.18054661
75MP0004264_abnormal_extraembryonic_tissu1.14454108
76MP0003303_peritoneal_inflammation1.13497188
77MP0002080_prenatal_lethality1.12420395
78MP0005220_abnormal_exocrine_pancreas1.11003656
79MP0000428_abnormal_craniofacial_morphol1.10889415
80MP0000313_abnormal_cell_death1.09644718
81MP0003115_abnormal_respiratory_system1.07249477
82MP0000049_abnormal_middle_ear1.07054845
83MP0002085_abnormal_embryonic_tissue1.06603315
84MP0001299_abnormal_eye_distance/1.05780139
85MP0003984_embryonic_growth_retardation1.05755547
86MP0000609_abnormal_liver_physiology1.05607424
87MP0004185_abnormal_adipocyte_glucose1.05076501
88MP0000858_altered_metastatic_potential1.03634686
89MP0003283_abnormal_digestive_organ1.03624094
90MP0000689_abnormal_spleen_morphology1.03308914
91MP0002086_abnormal_extraembryonic_tissu1.03231780
92MP0002163_abnormal_gland_morphology1.02824528
93MP0002088_abnormal_embryonic_growth/wei1.02715072
94MP0002090_abnormal_vision1.02176777
95MP0005332_abnormal_amino_acid1.01988218
96MP0003786_premature_aging1.01938008
97MP0001835_abnormal_antigen_presentation1.01282729
98MP0003938_abnormal_ear_development1.00694720
99MP0003566_abnormal_cell_adhesion0.99600799
100MP0001764_abnormal_homeostasis0.99555183
101MP0008875_abnormal_xenobiotic_pharmacok0.98119808
102MP0005023_abnormal_wound_healing0.98072162
103MP0009697_abnormal_copulation0.96069467
104MP0003878_abnormal_ear_physiology0.95707269
105MP0005377_hearing/vestibular/ear_phenot0.95707269
106MP0001853_heart_inflammation0.95464971
107MP0002722_abnormal_immune_system0.95114218
108MP0002405_respiratory_system_inflammati0.94285803
109MP0009384_cardiac_valve_regurgitation0.94114773
110MP0003705_abnormal_hypodermis_morpholog0.93389822
111MP0003191_abnormal_cellular_cholesterol0.92433642
112MP0005310_abnormal_salivary_gland0.92344524
113MP0005499_abnormal_olfactory_system0.92262254
114MP0005394_taste/olfaction_phenotype0.92262254
115MP0000598_abnormal_liver_morphology0.91804923
116MP0001119_abnormal_female_reproductive0.91751855
117MP0002398_abnormal_bone_marrow0.91226055
118MP0009785_altered_susceptibility_to0.91221359
119MP0002084_abnormal_developmental_patter0.90505020
120MP0005395_other_phenotype0.90438741
121MP0002877_abnormal_melanocyte_morpholog0.89691484
122MP0004858_abnormal_nervous_system0.89604926
123MP0000750_abnormal_muscle_regeneration0.87126424
124MP0003453_abnormal_keratinocyte_physiol0.86233089
125MP0003385_abnormal_body_wall0.85846670
126MP0003646_muscle_fatigue0.85377739
127MP0005058_abnormal_lysosome_morphology0.83749026
128MP0000762_abnormal_tongue_morphology0.83613614
129MP0001346_abnormal_lacrimal_gland0.82680565
130MP0001800_abnormal_humoral_immune0.82620173
131MP0005408_hypopigmentation0.82545150
132MP0002210_abnormal_sex_determination0.82334778
133MP0005621_abnormal_cell_physiology0.82237722
134MP0004197_abnormal_fetal_growth/weight/0.82190940
135MP0008789_abnormal_olfactory_epithelium0.81222528
136MP0009703_decreased_birth_body0.81182022
137MP0003567_abnormal_fetal_cardiomyocyte0.80795823
138MP0005319_abnormal_enzyme/_coenzyme0.80353029
139MP0006036_abnormal_mitochondrial_physio0.80085368
140MP0002429_abnormal_blood_cell0.80072105
141MP0008877_abnormal_DNA_methylation0.79138594
142MP0002419_abnormal_innate_immunity0.78712561
143MP0004808_abnormal_hematopoietic_stem0.78099176
144MP0000432_abnormal_head_morphology0.77850413
145MP0000685_abnormal_immune_system0.77729982
146MP0001145_abnormal_male_reproductive0.77426892
147MP0002132_abnormal_respiratory_system0.76663694
148MP0006035_abnormal_mitochondrial_morpho0.76601686
149MP0000653_abnormal_sex_gland0.76569112
150MP0002452_abnormal_antigen_presenting0.76477083
151MP0003935_abnormal_craniofacial_develop0.76194908
152MP0000716_abnormal_immune_system0.75825876
153MP0005464_abnormal_platelet_physiology0.75603807
154MP0000678_abnormal_parathyroid_gland0.75528653
155MP0003699_abnormal_female_reproductive0.74469836
156MP0001845_abnormal_inflammatory_respons0.74452980
157MP0005025_abnormal_response_to0.74224293
158MP0005000_abnormal_immune_tolerance0.73871634
159MP0002282_abnormal_trachea_morphology0.73331404
160MP0000477_abnormal_intestine_morphology0.72659439
161MP0000358_abnormal_cell_content/0.72130584

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.37496676
2Prolonged partial thromboplastin time (HP:0003645)4.86036294
3Birth length less than 3rd percentile (HP:0003561)4.73576977
4Carpal bone hypoplasia (HP:0001498)4.30911889
5Breast hypoplasia (HP:0003187)4.11951240
6Vaginal fistula (HP:0004320)3.69656765
7Pancreatic islet-cell hyperplasia (HP:0004510)3.67794869
8Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.53303879
9Joint hemorrhage (HP:0005261)3.52066293
10Rough bone trabeculation (HP:0100670)3.42348788
11Multiple enchondromatosis (HP:0005701)3.31453415
12Hypercholesterolemia (HP:0003124)3.29920939
13Hyperglycinuria (HP:0003108)3.27874761
14Hyperglycinemia (HP:0002154)3.19426078
15Oral leukoplakia (HP:0002745)3.19308431
16Small epiphyses (HP:0010585)3.12202115
17Choanal stenosis (HP:0000452)3.10898713
18Broad alveolar ridges (HP:0000187)3.07620868
19Patellar aplasia (HP:0006443)3.03523535
20Hepatoblastoma (HP:0002884)3.01851844
21Aplasia/Hypoplasia of the patella (HP:0006498)2.95164951
22Pustule (HP:0200039)2.94942778
23Nephroblastoma (Wilms tumor) (HP:0002667)2.79038583
24Secondary amenorrhea (HP:0000869)2.78425812
25Complement deficiency (HP:0004431)2.77991144
26Rectovaginal fistula (HP:0000143)2.75924517
27Rectal fistula (HP:0100590)2.75924517
28Hypolipoproteinemia (HP:0010981)2.75541172
29Abnormality of the common coagulation pathway (HP:0010990)2.70978056
30Abnormality of the anterior horn cell (HP:0006802)2.70813047
31Degeneration of anterior horn cells (HP:0002398)2.70813047
32Microretrognathia (HP:0000308)2.68285769
33Glomerulonephritis (HP:0000099)2.66890687
34Hypoplasia of the capital femoral epiphysis (HP:0003090)2.65135382
35Abnormality of cells of the erythroid lineage (HP:0012130)2.63575035
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.63341265
37Absent epiphyses (HP:0010577)2.63341265
38Embryonal renal neoplasm (HP:0011794)2.62275291
39Premature ovarian failure (HP:0008209)2.59855050
40Coronal craniosynostosis (HP:0004440)2.58480625
41Impulsivity (HP:0100710)2.58440646
42Hypophosphatemic rickets (HP:0004912)2.58154310
43Aplastic anemia (HP:0001915)2.55491007
44Abnormal number of erythroid precursors (HP:0012131)2.53899364
45Bifid tongue (HP:0010297)2.52037861
46Recurrent bacterial skin infections (HP:0005406)2.52026679
47Abnormality of the lacrimal duct (HP:0011481)2.51332082
48Epiphyseal dysplasia (HP:0002656)2.49788255
49Recurrent abscess formation (HP:0002722)2.47952742
50Hypoglycemic coma (HP:0001325)2.43173922
51Abnormality of serine family amino acid metabolism (HP:0010894)2.43003681
52Abnormality of glycine metabolism (HP:0010895)2.43003681
53Abnormal trabecular bone morphology (HP:0100671)2.42692211
54Myelomeningocele (HP:0002475)2.42576651
55Facial hemangioma (HP:0000329)2.42009685
56Asymmetry of the thorax (HP:0001555)2.40242307
57Reticulocytopenia (HP:0001896)2.39565922
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39520946
59Hypoalphalipoproteinemia (HP:0003233)2.38904398
60Abnormality of carpal bone ossification (HP:0006257)2.38085634
61Alacrima (HP:0000522)2.37998140
62Gout (HP:0001997)2.37875316
63Increased serum pyruvate (HP:0003542)2.37420478
64Abnormality of glycolysis (HP:0004366)2.36036522
65Intestinal fistula (HP:0100819)2.34148574
66Septo-optic dysplasia (HP:0100842)2.30202240
67Chromsome breakage (HP:0040012)2.28882180
68Male infertility (HP:0003251)2.23536529
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.22843280
70Irregular epiphyses (HP:0010582)2.22597829
71Slender long bone (HP:0003100)2.21228066
72Diastasis recti (HP:0001540)2.21049122
73Absent eyebrow (HP:0002223)2.20448388
74Entropion (HP:0000621)2.20345972
75Abnormal tarsal ossification (HP:0008369)2.19528241
76Abnormality of endocrine pancreas physiology (HP:0012093)2.15985341
77Abnormality of the pancreatic islet cells (HP:0006476)2.15985341
78Selective tooth agenesis (HP:0001592)2.15133015
79Flat acetabular roof (HP:0003180)2.13839291
80Hypoplastic pelvis (HP:0008839)2.13661071
81Broad palm (HP:0001169)2.13595787
82Duplication of thumb phalanx (HP:0009942)2.13164588
83Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12760382
84Squamous cell carcinoma (HP:0002860)2.10176334
85Cerebral hypomyelination (HP:0006808)2.10036027
86Abnormality of the lumbar spine (HP:0100712)2.09399248
87Breast aplasia (HP:0100783)2.09269324
88Hemorrhage of the eye (HP:0011885)2.08690467
89Progressive muscle weakness (HP:0003323)2.07218655
90Macrocytic anemia (HP:0001972)2.07161266
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05148400
92Myocardial infarction (HP:0001658)2.03736873
93Partial duplication of thumb phalanx (HP:0009944)2.03464979
94Abnormal ventriculo-arterial connection (HP:0011563)2.03349193
95Transposition of the great arteries (HP:0001669)2.03349193
96Abnormal connection of the cardiac segments (HP:0011545)2.03349193
97Hypobetalipoproteinemia (HP:0003563)2.03112315
98Capillary hemangiomas (HP:0005306)2.02290981
99Systemic lupus erythematosus (HP:0002725)2.01729360
100Anal stenosis (HP:0002025)2.01092481
101Spinal muscular atrophy (HP:0007269)2.01084807
102Bone marrow hypocellularity (HP:0005528)2.00958673
103Thrombocytosis (HP:0001894)2.00946591
104Abnormality of methionine metabolism (HP:0010901)2.00466816
105Anophthalmia (HP:0000528)2.00328614
106Abnormality of serum amino acid levels (HP:0003112)2.00071154
107Enlarged kidneys (HP:0000105)1.99833232
108Spontaneous abortion (HP:0005268)1.99120959
109Bronchomalacia (HP:0002780)1.98353281
110Abnormality of the nasal septum (HP:0000419)1.97621618
111Hypoglycemic seizures (HP:0002173)1.96441953
112Vascular calcification (HP:0004934)1.96440995
113Renal duplication (HP:0000075)1.96086296
114Abnormality of lateral ventricle (HP:0030047)1.95438936
115Premature graying of hair (HP:0002216)1.95415736
116Agnosia (HP:0010524)1.94446319
117Flared iliac wings (HP:0002869)1.94345669
118Recurrent gram-negative bacterial infections (HP:0005420)1.94008995
119Abnormality of pain sensation (HP:0010832)1.93790062
120Impaired pain sensation (HP:0007328)1.93790062
121Wide nose (HP:0000445)1.93097018
122Upper motor neuron abnormality (HP:0002127)1.93067527
123Poikiloderma (HP:0001029)1.92870881
124Facial cleft (HP:0002006)1.91980152
125Abnormality of the nasolacrimal system (HP:0000614)1.91694753
126Abnormality of the alveolar ridges (HP:0006477)1.89419975
127Bilateral microphthalmos (HP:0007633)1.89078621
128Abnormality of the motor neurons (HP:0002450)1.88882812
129Abnormal neuron morphology (HP:0012757)1.88882812
130Neoplasm of the pancreas (HP:0002894)1.88406231
131Acanthocytosis (HP:0001927)1.87852007
132Absent radius (HP:0003974)1.86895108
133Abnormality of pyrimidine metabolism (HP:0004353)1.86167413
134Myelodysplasia (HP:0002863)1.86063579
135Aplasia/Hypoplasia of the breasts (HP:0010311)1.85617394
136Abnormal lung lobation (HP:0002101)1.85613518
137Megaloblastic anemia (HP:0001889)1.85594902
138Decreased lacrimation (HP:0000633)1.84597172
139Shawl scrotum (HP:0000049)1.84297801
140Absent thumb (HP:0009777)1.84294531
141Reduced antithrombin III activity (HP:0001976)1.84210381
142Trismus (HP:0000211)1.83801077
143Pterygium (HP:0001059)1.83316916
144Hepatocellular carcinoma (HP:0001402)1.82800789
145Delayed epiphyseal ossification (HP:0002663)1.81360381
146Abnormality of complement system (HP:0005339)1.80003132
147Nausea (HP:0002018)1.77642842
148Broad thumb (HP:0011304)1.75405750
149Preaxial foot polydactyly (HP:0001841)1.75052684
150Personality changes (HP:0000751)1.74985498
151Abnormality of the middle phalanges of the toes (HP:0010183)1.74810706
152Absent forearm bone (HP:0003953)1.74705142
153Aplasia involving forearm bones (HP:0009822)1.74705142
154Epidermoid cyst (HP:0200040)1.74125689
155Hypoplasia of the fovea (HP:0007750)1.73983435
156Aplasia/Hypoplasia of the fovea (HP:0008060)1.73983435
157Abnormality of sulfur amino acid metabolism (HP:0004339)1.72089363
158Abnormality of the ileum (HP:0001549)1.71727561
159Meckel diverticulum (HP:0002245)1.71534356
160Hemivertebrae (HP:0002937)1.70844114
161Type I transferrin isoform profile (HP:0003642)1.69351972
162Abnormality of the distal phalanges of the toes (HP:0010182)1.68011458
163Intrahepatic cholestasis (HP:0001406)1.67921588
164Death in infancy (HP:0001522)1.66511939
165Poor head control (HP:0002421)1.65659219
166IgM deficiency (HP:0002850)1.65199565
167Aplasia/hypoplasia of the humerus (HP:0006507)1.63918150
168Cervical subluxation (HP:0003308)1.63657852
169Spastic diplegia (HP:0001264)1.62594294
170Anomalous pulmonary venous return (HP:0010772)1.62515730
171Abnormality of macrophages (HP:0004311)1.62151361
172Tracheoesophageal fistula (HP:0002575)1.62000983
173Abnormal cartilage morphology (HP:0002763)1.61725755
174Prolonged neonatal jaundice (HP:0006579)1.61572749
175Hypochromic anemia (HP:0001931)1.60393069
176Muscle fiber atrophy (HP:0100295)1.60247514
177Xanthomatosis (HP:0000991)1.57779108
178Abnormality of chromosome stability (HP:0003220)1.56792470
179Sparse eyelashes (HP:0000653)1.56667285
180Pallor (HP:0000980)1.56548226
181Eczematoid dermatitis (HP:0000976)1.56079781
182Supernumerary spleens (HP:0009799)1.55738922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR44.61869380
2BUB13.78940847
3PBK3.44292709
4WEE13.38772516
5FGFR23.06148016
6NEK22.90967608
7TAF12.79581877
8TESK22.49652045
9NME22.36112524
10FGFR12.34384181
11ICK2.26289512
12EIF2AK12.25194014
13VRK22.23801824
14DYRK32.18618962
15FGFR32.14927270
16BRSK22.11068437
17CDK122.02171586
18TTK1.97167158
19PLK41.94883738
20LATS21.94008369
21CDC71.86230669
22WNK41.80367576
23TYRO31.76571405
24PLK11.75939207
25EEF2K1.73222869
26RPS6KA41.68142006
27LMTK21.65895976
28MAPKAPK31.64113061
29RPS6KB21.61875189
30SMG11.61003890
31PDGFRA1.58437705
32MAP3K31.58361017
33STK101.58210628
34INSRR1.55654834
35EIF2AK31.52132206
36MAP3K111.51447319
37ARAF1.49792191
38CDK71.48893862
39PIM21.46949553
40FLT31.45399949
41PASK1.44824182
42ERN11.39107145
43MAP3K61.38801703
44TSSK61.37933513
45PIM11.35586885
46BRAF1.33966374
47BRSK11.32544701
48MAP3K81.32468609
49LATS11.30499626
50TLK11.30268264
51CDK41.29546349
52MAP2K31.29305624
53AURKB1.27089791
54TAOK11.24034277
55STK31.23438261
56IRAK31.23046168
57MAP4K11.22614765
58RAF11.22126453
59STK161.19410598
60STK38L1.15164880
61FGR1.12697038
62CHEK21.12088637
63AURKA1.09783607
64EPHA21.09244020
65BCR1.06447872
66ABL21.05722399
67VRK11.03199362
68TNIK1.00815456
69NEK10.98840275
70KSR20.97452570
71BCKDK0.94564399
72DYRK20.93674346
73TAOK30.92769346
74STK40.91446735
75TRIB30.91168748
76ALK0.90308257
77TRIM280.88368719
78DYRK1B0.87050610
79BMX0.86622450
80PLK30.85564383
81SRPK10.84911156
82MAP3K100.82642254
83MKNK10.81834433
84NME10.81605082
85ATR0.79936381
86MKNK20.79854821
87MOS0.79580386
88ERBB40.78542157
89PDK20.78019823
90TYK20.77247635
91MAP3K90.76499514
92SCYL20.75552875
93ACVR1B0.75369364
94MAPK110.73365953
95LRRK20.70642536
96BLK0.70483049
97MAP2K20.69655721
98TEC0.68215183
99EPHA40.67567954
100PKN20.65620954
101BTK0.64966061
102KIT0.64617071
103CHEK10.63944338
104CDK90.63086669
105PTK20.63024625
106CDK60.62324079
107CSF1R0.61340899
108JAK30.60149009
109DDR20.59614661
110CDK80.58647643
111WNK30.57270878
112PAK40.57005673
113GRK60.55265072
114RIPK10.54070690
115PRKCI0.54054256
116CSNK1E0.52835888
117PAK10.52456951
118ATM0.50399753
119CDK20.48989705
120ERBB20.48525455
121TBK10.47927773
122CAMK1D0.47501247
123TRPM70.45555948
124DAPK10.45241011
125NUAK10.44710128
126STK390.44382892
127MTOR0.43402891
128MET0.43077301
129IKBKB0.42610125
130CSNK1G10.42122317
131MATK0.41719810
132PTK60.41671271
133MELK0.41412561
134ZAK0.41078296
135STK240.40854729
136CDK10.40090039
137MST40.40030451
138RPS6KA50.39263927
139PRKG20.38939852
140MAP3K50.38621671
141CSNK2A10.38526318
142HIPK20.38145028
143CSNK2A20.38035958
144WNK10.37776696
145MAP3K40.37752595
146CDK190.34623601

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.41717561
2Vitamin B6 metabolism_Homo sapiens_hsa007503.22009586
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10598023
4Mismatch repair_Homo sapiens_hsa034302.92505267
5RNA polymerase_Homo sapiens_hsa030202.86077381
6Folate biosynthesis_Homo sapiens_hsa007902.79976857
7Steroid biosynthesis_Homo sapiens_hsa001002.79849415
8Complement and coagulation cascades_Homo sapiens_hsa046102.64557810
9Base excision repair_Homo sapiens_hsa034102.43856654
10Ribosome_Homo sapiens_hsa030102.39190347
11RNA transport_Homo sapiens_hsa030132.37658628
12Cell cycle_Homo sapiens_hsa041102.33841784
13One carbon pool by folate_Homo sapiens_hsa006702.16393159
14Pyrimidine metabolism_Homo sapiens_hsa002402.10283393
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05968984
16Homologous recombination_Homo sapiens_hsa034402.05869574
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04711374
18Nucleotide excision repair_Homo sapiens_hsa034201.92939543
19Proteasome_Homo sapiens_hsa030501.90950835
20Basal transcription factors_Homo sapiens_hsa030221.85278673
21Spliceosome_Homo sapiens_hsa030401.83517237
22Pyruvate metabolism_Homo sapiens_hsa006201.81734606
23Sulfur relay system_Homo sapiens_hsa041221.76437654
24Fat digestion and absorption_Homo sapiens_hsa049751.71087169
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.64029894
26p53 signaling pathway_Homo sapiens_hsa041151.62845078
27Propanoate metabolism_Homo sapiens_hsa006401.61649201
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.59188993
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55603976
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55454731
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53592163
32Pentose phosphate pathway_Homo sapiens_hsa000301.51928494
33Fatty acid metabolism_Homo sapiens_hsa012121.48483824
34Selenocompound metabolism_Homo sapiens_hsa004501.46467314
35Fatty acid elongation_Homo sapiens_hsa000621.45536345
36N-Glycan biosynthesis_Homo sapiens_hsa005101.42588776
37RNA degradation_Homo sapiens_hsa030181.35895290
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.31412383
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29534220
40Fanconi anemia pathway_Homo sapiens_hsa034601.25102715
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20477865
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.18401396
43Biosynthesis of amino acids_Homo sapiens_hsa012301.17105655
44Basal cell carcinoma_Homo sapiens_hsa052171.10952793
45PPAR signaling pathway_Homo sapiens_hsa033201.10235708
46Non-homologous end-joining_Homo sapiens_hsa034501.05170996
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02650137
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.01089657
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00395995
50Glutathione metabolism_Homo sapiens_hsa004800.99414114
51Fatty acid biosynthesis_Homo sapiens_hsa000610.96891622
52Phenylalanine metabolism_Homo sapiens_hsa003600.94222879
53Purine metabolism_Homo sapiens_hsa002300.93469711
54Herpes simplex infection_Homo sapiens_hsa051680.92920599
55Lysine degradation_Homo sapiens_hsa003100.90833209
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90211250
57Regulation of autophagy_Homo sapiens_hsa041400.88624841
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88357498
59Epstein-Barr virus infection_Homo sapiens_hsa051690.86741349
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86624522
61Tyrosine metabolism_Homo sapiens_hsa003500.86502442
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85454441
63mRNA surveillance pathway_Homo sapiens_hsa030150.83199984
64Hippo signaling pathway_Homo sapiens_hsa043900.81739233
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81112275
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.80701396
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78535096
68Butanoate metabolism_Homo sapiens_hsa006500.77589763
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.77286423
70Bladder cancer_Homo sapiens_hsa052190.69824304
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69351949
72Galactose metabolism_Homo sapiens_hsa000520.68960618
73Other glycan degradation_Homo sapiens_hsa005110.67252479
74Arginine and proline metabolism_Homo sapiens_hsa003300.67147606
75Antigen processing and presentation_Homo sapiens_hsa046120.66935533
76Thyroid cancer_Homo sapiens_hsa052160.66512683
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66346025
78Adherens junction_Homo sapiens_hsa045200.66230361
79Arginine biosynthesis_Homo sapiens_hsa002200.63928804
80Fructose and mannose metabolism_Homo sapiens_hsa000510.63813090
81Carbon metabolism_Homo sapiens_hsa012000.63743383
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63321623
83Legionellosis_Homo sapiens_hsa051340.63123166
84Wnt signaling pathway_Homo sapiens_hsa043100.62885849
85Peroxisome_Homo sapiens_hsa041460.60908618
86Glycerolipid metabolism_Homo sapiens_hsa005610.60248804
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.60099817
88Vitamin digestion and absorption_Homo sapiens_hsa049770.59647034
89Renin-angiotensin system_Homo sapiens_hsa046140.58036631
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57456405
91Viral carcinogenesis_Homo sapiens_hsa052030.57434648
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57223520
93mTOR signaling pathway_Homo sapiens_hsa041500.55794688
94Staphylococcus aureus infection_Homo sapiens_hsa051500.53055892
95Linoleic acid metabolism_Homo sapiens_hsa005910.51413128
96Tryptophan metabolism_Homo sapiens_hsa003800.51086887
97Apoptosis_Homo sapiens_hsa042100.50572178
98Sphingolipid metabolism_Homo sapiens_hsa006000.49959276
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49572459
100Acute myeloid leukemia_Homo sapiens_hsa052210.49474591
101Systemic lupus erythematosus_Homo sapiens_hsa053220.48537731
102Tight junction_Homo sapiens_hsa045300.48456062
103Protein export_Homo sapiens_hsa030600.48409370
104TGF-beta signaling pathway_Homo sapiens_hsa043500.47501135
105Hedgehog signaling pathway_Homo sapiens_hsa043400.47471863
106Hepatitis B_Homo sapiens_hsa051610.46535024
107ECM-receptor interaction_Homo sapiens_hsa045120.44935909
108Retinol metabolism_Homo sapiens_hsa008300.44870487
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43621189
110Leishmaniasis_Homo sapiens_hsa051400.43608624
111Oocyte meiosis_Homo sapiens_hsa041140.43041813
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42943863
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42895997
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41115401
115Bile secretion_Homo sapiens_hsa049760.39412700
116Shigellosis_Homo sapiens_hsa051310.38922750
117Influenza A_Homo sapiens_hsa051640.38516726
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37770782
119Chemical carcinogenesis_Homo sapiens_hsa052040.37431976
120Histidine metabolism_Homo sapiens_hsa003400.37063981
121beta-Alanine metabolism_Homo sapiens_hsa004100.37059218
122Small cell lung cancer_Homo sapiens_hsa052220.36372540
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36168989
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35697450
125Metabolic pathways_Homo sapiens_hsa011000.35579880
126MicroRNAs in cancer_Homo sapiens_hsa052060.35456681
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.34798395
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.34725223
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34253231
130Fatty acid degradation_Homo sapiens_hsa000710.34031474
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33655938
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32791086
133Starch and sucrose metabolism_Homo sapiens_hsa005000.31584140
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31172939
135Lysosome_Homo sapiens_hsa041420.30695451
136Arachidonic acid metabolism_Homo sapiens_hsa005900.30684634

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