SSFA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.02463235
2establishment of skin barrier (GO:0061436)4.89186503
3hypotonic response (GO:0006971)4.76848349
4regulation of water loss via skin (GO:0033561)4.66888674
5COPI coating of Golgi vesicle (GO:0048205)4.05103356
6Golgi transport vesicle coating (GO:0048200)4.05103356
7nuclear pore complex assembly (GO:0051292)4.01353602
8cytoskeletal anchoring at plasma membrane (GO:0007016)3.93474413
9negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.88115780
10regulation of pigment cell differentiation (GO:0050932)3.86293750
11peptidyl-threonine dephosphorylation (GO:0035970)3.68511815
12mesodermal cell differentiation (GO:0048333)3.65363290
13mammary gland epithelial cell proliferation (GO:0033598)3.57096101
14phospholipid efflux (GO:0033700)3.51152911
15hemidesmosome assembly (GO:0031581)3.47828337
16intestinal cholesterol absorption (GO:0030299)3.39267612
17embryonic process involved in female pregnancy (GO:0060136)3.32657750
18multicellular organismal water homeostasis (GO:0050891)3.28601521
19nuclear pore organization (GO:0006999)3.24669266
20regulation of transforming growth factor beta2 production (GO:0032909)3.20558079
21cell-substrate junction assembly (GO:0007044)3.20019357
22regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.19538811
23regulation of glucose import in response to insulin stimulus (GO:2001273)3.17264429
24positive regulation of osteoblast proliferation (GO:0033690)3.11145957
25regulation of phospholipase A2 activity (GO:0032429)3.10948100
26activation of Rac GTPase activity (GO:0032863)3.05071046
27barbed-end actin filament capping (GO:0051016)3.04081575
28water homeostasis (GO:0030104)3.00166352
29positive regulation of p38MAPK cascade (GO:1900745)2.99385870
30positive regulation of cholesterol efflux (GO:0010875)2.96506461
31regulation of cholesterol homeostasis (GO:2000188)2.96488654
32COPII vesicle coating (GO:0048208)2.89971781
33positive regulation of developmental pigmentation (GO:0048087)2.88351862
34positive regulation of sterol transport (GO:0032373)2.88153226
35positive regulation of cholesterol transport (GO:0032376)2.88153226
36keratinization (GO:0031424)2.87550514
37gap junction assembly (GO:0016264)2.87356606
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.84882363
39dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.84497578
40positive regulation of cellular response to insulin stimulus (GO:1900078)2.83012425
41regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.82571621
42low-density lipoprotein particle clearance (GO:0034383)2.81998739
43negative regulation of anoikis (GO:2000811)2.81644524
44bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80277140
45negative regulation of DNA repair (GO:0045738)2.79976936
46pore complex assembly (GO:0046931)2.75577491
47modulation by symbiont of host immune response (GO:0052553)2.75276406
48positive regulation by symbiont of host defense response (GO:0052509)2.75276406
49modulation by symbiont of host defense response (GO:0052031)2.75276406
50modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75276406
51modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75276406
52positive regulation by organism of defense response of other organism involved in symbiotic interact2.75276406
53surfactant homeostasis (GO:0043129)2.73909366
54peptidyl-glutamic acid carboxylation (GO:0017187)2.73672971
55protein carboxylation (GO:0018214)2.73672971
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.72602901
57triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.71075386
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.69389095
59L-phenylalanine catabolic process (GO:0006559)2.69389095
60hormone catabolic process (GO:0042447)2.68635964
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68439008
62vesicle coating (GO:0006901)2.68145403
63lung vasculature development (GO:0060426)2.66956312
64glomerular visceral epithelial cell development (GO:0072015)2.65953869
65bone remodeling (GO:0046849)2.65917776
66sulfur amino acid catabolic process (GO:0000098)2.64988864
67keratinocyte differentiation (GO:0030216)2.64632740
68protein hydroxylation (GO:0018126)2.64195747
69negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.63470105
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60583361
71membrane raft organization (GO:0031579)2.58470573
72regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.58446233
73regulation of membrane protein ectodomain proteolysis (GO:0051043)2.58196492
74endothelial cell morphogenesis (GO:0001886)2.58122337
75alpha-linolenic acid metabolic process (GO:0036109)2.57967579
76regulation of cholesterol storage (GO:0010885)2.57923113
77negative regulation of chondrocyte differentiation (GO:0032331)2.57327591
78negative regulation of fatty acid transport (GO:2000192)2.56752213
79establishment of endothelial barrier (GO:0061028)2.55925013
80growth hormone receptor signaling pathway (GO:0060396)2.54169712
81adherens junction assembly (GO:0034333)2.53930534
82regulation of endothelial cell chemotaxis (GO:2001026)2.53826228
83positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.52837260
84skin morphogenesis (GO:0043589)2.52165049
85transcytosis (GO:0045056)2.52076751
86apoptotic cell clearance (GO:0043277)2.51311903
87linoleic acid metabolic process (GO:0043651)2.50945542
88plasma lipoprotein particle clearance (GO:0034381)2.50838210
89epidermal cell differentiation (GO:0009913)2.50039395
90phospholipid homeostasis (GO:0055091)2.49431904
91focal adhesion assembly (GO:0048041)2.48115653
92cell-substrate adherens junction assembly (GO:0007045)2.48115653
93regulation of interferon-beta biosynthetic process (GO:0045357)2.47670428
94regulation of anoikis (GO:2000209)2.47472595
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.46894772
96L-phenylalanine metabolic process (GO:0006558)2.46894772
97cysteine metabolic process (GO:0006534)2.46354401
98SMAD protein complex assembly (GO:0007183)2.46229652
99homocysteine metabolic process (GO:0050667)2.46159809
100chemical homeostasis within a tissue (GO:0048875)2.45510850
101regulation of nucleobase-containing compound transport (GO:0032239)2.45376482
102morphogenesis of an epithelial sheet (GO:0002011)2.44596258
103iron ion import (GO:0097286)2.43342891
104negative regulation of protein localization to plasma membrane (GO:1903077)2.41993676
105regulation of RNA export from nucleus (GO:0046831)2.41767751
106negative regulation of smooth muscle cell differentiation (GO:0051151)2.40119745
107mRNA transcription (GO:0009299)2.39948795
108positive regulation of fatty acid beta-oxidation (GO:0032000)2.39616195
109hippo signaling (GO:0035329)2.39494002
110definitive hemopoiesis (GO:0060216)2.39429186
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39279067
112response to methylmercury (GO:0051597)2.38965235
113intestinal absorption (GO:0050892)2.38939911
114fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.38692869
115embryonic eye morphogenesis (GO:0048048)2.38381715
116cellular senescence (GO:0090398)2.37840942
117protein localization to microtubule (GO:0035372)2.37637745
118negative regulation of lipase activity (GO:0060192)2.37451851
119fibrinolysis (GO:0042730)2.35941483
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.35806216
121positive regulation of insulin receptor signaling pathway (GO:0046628)2.35416353
122branching involved in mammary gland duct morphogenesis (GO:0060444)2.34951171
123detection of bacterium (GO:0016045)2.34321060
124positive regulation of lipid catabolic process (GO:0050996)2.34309088
125epithelial cell-cell adhesion (GO:0090136)2.34306111
126urea metabolic process (GO:0019627)2.33573349
127urea cycle (GO:0000050)2.33573349
128negative regulation of keratinocyte proliferation (GO:0010839)2.33009583
129endodermal cell differentiation (GO:0035987)2.32914304
130protein localization to endosome (GO:0036010)2.32717081
131reverse cholesterol transport (GO:0043691)2.32071482
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31755055
133positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.31551039
134regulation of glomerular filtration (GO:0003093)2.31300606
135G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.30714899
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.30558287
137positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.30049887
138high-density lipoprotein particle remodeling (GO:0034375)2.29724295
139detection of other organism (GO:0098543)2.29570415
140positive regulation of extracellular matrix organization (GO:1903055)2.28998305
141plasma membrane repair (GO:0001778)2.28896002
142regulation of p38MAPK cascade (GO:1900744)2.28788311
143regulation of keratinocyte differentiation (GO:0045616)2.28778662
144regulation of triglyceride catabolic process (GO:0010896)2.28724085
145response to laminar fluid shear stress (GO:0034616)2.28547009
146endocardial cushion development (GO:0003197)2.28536601
147regulation of mitotic spindle organization (GO:0060236)2.28408066
148positive regulation of receptor recycling (GO:0001921)2.27426745
149stress fiber assembly (GO:0043149)2.26899564
150glomerular epithelial cell development (GO:0072310)2.26579608
151adhesion of symbiont to host cell (GO:0044650)2.26466203
152virion attachment to host cell (GO:0019062)2.26466203
153complement activation, alternative pathway (GO:0006957)2.26277420
154amino-acid betaine metabolic process (GO:0006577)2.25956350
155chondrocyte proliferation (GO:0035988)2.24862996
156negative regulation of potassium ion transmembrane transport (GO:1901380)2.24414233
157aromatic amino acid family catabolic process (GO:0009074)2.24245085
158cell-cell junction assembly (GO:0007043)2.23595727
159cellular modified amino acid catabolic process (GO:0042219)2.22882085
160regulation of protein localization to plasma membrane (GO:1903076)2.22874774
161protein retention in ER lumen (GO:0006621)2.22273276
162regulation of early endosome to late endosome transport (GO:2000641)2.22016289
163cell adhesion mediated by integrin (GO:0033627)2.21846840
164regulation of cholesterol transport (GO:0032374)2.21729070
165regulation of sterol transport (GO:0032371)2.21729070
166macrophage activation involved in immune response (GO:0002281)2.21491782
167positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.20941110
168valine metabolic process (GO:0006573)2.20806371
169cholesterol efflux (GO:0033344)2.20532384
170negative regulation of lipid storage (GO:0010888)2.20229098
171sphingosine metabolic process (GO:0006670)2.20024266
172cholesterol transport (GO:0030301)2.18411946
173sterol transport (GO:0015918)2.18411946
174negative regulation of cholesterol transport (GO:0032375)2.18297665
175negative regulation of sterol transport (GO:0032372)2.18297665
176keratinocyte proliferation (GO:0043616)2.18142575
177lysine catabolic process (GO:0006554)2.17764852
178lysine metabolic process (GO:0006553)2.17764852
179lipoprotein metabolic process (GO:0042157)2.16919618
180T-helper 1 type immune response (GO:0042088)2.13809571
181regulation of cholesterol efflux (GO:0010874)2.12149581
182cellular response to growth hormone stimulus (GO:0071378)2.12012309
183positive regulation of interferon-alpha production (GO:0032727)2.11928575
184primary alcohol catabolic process (GO:0034310)2.10411079
185macroautophagy (GO:0016236)2.09307378
186adhesion of symbiont to host (GO:0044406)2.08770397
187bile acid biosynthetic process (GO:0006699)2.06619427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.76095560
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.04761293
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.73655284
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35549374
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.03632873
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.91838441
7AR_21909140_ChIP-Seq_LNCAP_Human2.89138779
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.76942369
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75119760
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.42466769
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34887880
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20333855
13* ESR1_21235772_ChIP-Seq_MCF-7_Human2.13487505
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10518662
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.09202474
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.06550179
17CTNNB1_20460455_ChIP-Seq_HCT116_Human2.05927317
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03490003
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90703708
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86981629
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.84541702
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81482331
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80846341
24* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.80178369
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.73256500
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73128675
27* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71158360
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70496100
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69804849
30* BRD4_25478319_ChIP-Seq_HGPS_Human1.69365924
31CLOCK_20551151_ChIP-Seq_293T_Human1.68743775
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61441880
33P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60726637
34P63_26484246_Chip-Seq_KERATINOCYTES_Human1.60235328
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58851110
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.58555501
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57669376
38ATF3_27146783_Chip-Seq_COLON_Human1.57364791
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.55681769
40SOX2_20726797_ChIP-Seq_SW620_Human1.50667692
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50615254
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48705952
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48520572
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.47249274
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.46008803
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45554988
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45509343
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.44090670
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43086399
50* UBF1/2_26484160_Chip-Seq_HMECs_Human1.42750194
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42042333
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40287542
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.40072320
54GATA1_22025678_ChIP-Seq_K562_Human1.38027732
55CJUN_26792858_Chip-Seq_BT549_Human1.37066441
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35495635
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35269386
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35191151
59* GATA4_25053715_ChIP-Seq_YYC3_Human1.35098889
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34903010
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34782982
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34782982
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33847874
64TP53_16413492_ChIP-PET_HCT116_Human1.32694926
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.30584327
66NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29969849
67EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29439525
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25619142
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25415244
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.24488820
71CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23465021
72PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23246802
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21833456
74TCF7_22412390_ChIP-Seq_EML_Mouse1.20702145
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19140707
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18783864
77TP63_23658742_ChIP-Seq_EP156T_Human1.18451891
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17075295
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17075295
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15201053
81RXR_22108803_ChIP-Seq_LS180_Human1.14895416
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14634103
83TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13977532
84* FOXA2_19822575_ChIP-Seq_HepG2_Human1.13941418
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12238940
86* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10436330
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.09429015
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08522133
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08071735
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06541798
91GATA6_25053715_ChIP-Seq_YYC3_Human1.05422466
92* CHD1_26751641_Chip-Seq_LNCaP_Human1.05264128
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05193203
94VDR_24787735_ChIP-Seq_THP-1_Human1.04046778
95* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03955645
96AHR_22903824_ChIP-Seq_MCF-7_Human1.02026002
97* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01541160
98RACK7_27058665_Chip-Seq_MCF-7_Human0.99641805
99RUNX_20019798_ChIP-Seq_JUKART_Human0.98982943
100SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96774309
101RUNX1_27514584_Chip-Seq_MCF-7_Human0.96100706
102GATA2_19941826_ChIP-Seq_K562_Human0.95607228
103KLF5_25053715_ChIP-Seq_YYC3_Human0.94407581
104MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94163378
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94053698
106* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93172941
107TBX20_22328084_ChIP-Seq_HEART_Mouse0.92738568
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.92738568
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92521758
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92362264
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91817097
112ZNF263_19887448_ChIP-Seq_K562_Human0.91593696
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90477303
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90118140
115TCF4_18268006_ChIP-ChIP_LS174T_Human0.89483494
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89103923
117GATA3_24758297_ChIP-Seq_MCF-7_Human0.88701872
118GATA1_19941826_ChIP-Seq_K562_Human0.86564224
119TP53_18474530_ChIP-ChIP_U2OS_Human0.86313635
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85827195
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84581863
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84443185
123PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84353785
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82301549
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81924872
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80128216
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.79542796
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79287940
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.79164450
130TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79060818
131* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78997689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.27663521
2MP0002796_impaired_skin_barrier4.21923378
3MP0002254_reproductive_system_inflammat3.19211335
4MP0003191_abnormal_cellular_cholesterol3.16334359
5MP0005275_abnormal_skin_tensile3.13054411
6MP0005360_urolithiasis3.08502241
7MP0003705_abnormal_hypodermis_morpholog2.85434624
8MP0002139_abnormal_hepatobiliary_system2.77661635
9MP0003941_abnormal_skin_development2.67325505
10MP0005365_abnormal_bile_salt2.59139536
11MP0005085_abnormal_gallbladder_physiolo2.51869269
12MP0001666_abnormal_nutrient_absorption2.45859737
13MP0005409_darkened_coat_color2.44444928
14MP0004947_skin_inflammation2.37522960
15MP0005501_abnormal_skin_physiology2.35389115
16MP0002060_abnormal_skin_morphology2.23752649
17MP0003453_abnormal_keratinocyte_physiol2.13871790
18MP0005257_abnormal_intraocular_pressure2.12455071
19MP0005451_abnormal_body_composition2.06892612
20MP0003300_gastrointestinal_ulcer1.95818074
21MP0003252_abnormal_bile_duct1.95584335
22MP0010678_abnormal_skin_adnexa1.94948825
23MP0009780_abnormal_chondrocyte_physiolo1.94699004
24MP0003566_abnormal_cell_adhesion1.91462616
25MP0001216_abnormal_epidermal_layer1.91322575
26MP0005083_abnormal_biliary_tract1.89483658
27MP0003828_pulmonary_edema1.85573522
28MP0008875_abnormal_xenobiotic_pharmacok1.82609579
29MP0009840_abnormal_foam_cell1.82261919
30MP0005058_abnormal_lysosome_morphology1.71846073
31MP0000579_abnormal_nail_morphology1.61056428
32MP0010329_abnormal_lipoprotein_level1.56075895
33MP0003950_abnormal_plasma_membrane1.54875755
34MP0000383_abnormal_hair_follicle1.53598262
35MP0009697_abnormal_copulation1.53345849
36MP0003436_decreased_susceptibility_to1.51851325
37MP0002098_abnormal_vibrissa_morphology1.50886901
38MP0002138_abnormal_hepatobiliary_system1.45692139
39MP0010771_integument_phenotype1.45638139
40MP0004019_abnormal_vitamin_homeostasis1.42654757
41MP0000762_abnormal_tongue_morphology1.41066688
42MP0004233_abnormal_muscle_weight1.40864422
43MP0005248_abnormal_Harderian_gland1.38330397
44MP0002896_abnormal_bone_mineralization1.34151295
45MP0000377_abnormal_hair_follicle1.29703470
46MP0000647_abnormal_sebaceous_gland1.28784830
47MP0002877_abnormal_melanocyte_morpholog1.25200708
48MP0000537_abnormal_urethra_morphology1.24886824
49MP0004381_abnormal_hair_follicle1.24557981
50MP0003303_peritoneal_inflammation1.24447537
51MP0000733_abnormal_muscle_development1.24205741
52MP0006138_congestive_heart_failure1.23569826
53MP0001915_intracranial_hemorrhage1.23327101
54MP0002166_altered_tumor_susceptibility1.20675275
55MP0003279_aneurysm1.20041575
56MP0004808_abnormal_hematopoietic_stem1.19562812
57MP0003195_calcinosis1.18952257
58MP0005076_abnormal_cell_differentiation1.16568867
59* MP0002118_abnormal_lipid_homeostasis1.15074261
60MP0008438_abnormal_cutaneous_collagen1.14681489
61MP0005623_abnormal_meninges_morphology1.14508270
62MP0002009_preneoplasia1.13602303
63MP0009053_abnormal_anal_canal1.11863487
64* MP0000609_abnormal_liver_physiology1.11555496
65MP0005164_abnormal_response_to1.10365689
66MP0001191_abnormal_skin_condition1.10364417
67MP0009931_abnormal_skin_appearance1.09865675
68MP0009643_abnormal_urine_homeostasis1.08929997
69MP0003724_increased_susceptibility_to1.08017692
70MP0001879_abnormal_lymphatic_vessel1.06352542
71MP0005332_abnormal_amino_acid1.04978126
72MP0000604_amyloidosis1.04544521
73MP0002006_tumorigenesis1.03828642
74MP0000767_abnormal_smooth_muscle1.03571028
75MP0008057_abnormal_DNA_replication1.03063168
76MP0010352_gastrointestinal_tract_polyps1.01831804
77MP0002086_abnormal_extraembryonic_tissu1.01435992
78MP0003075_altered_response_to1.01342434
79MP0005621_abnormal_cell_physiology1.01067167
80MP0004272_abnormal_basement_membrane1.00161836
81MP0004264_abnormal_extraembryonic_tissu1.00101623
82MP0004782_abnormal_surfactant_physiolog0.99617574
83MP0005167_abnormal_blood-brain_barrier0.99364291
84MP0000427_abnormal_hair_cycle0.99259386
85MP0009764_decreased_sensitivity_to0.99077451
86MP0000013_abnormal_adipose_tissue0.98856825
87MP0006082_CNS_inflammation0.98277872
88MP0003868_abnormal_feces_composition0.96592217
89MP0001533_abnormal_skeleton_physiology0.96081566
90MP0000627_abnormal_mammary_gland0.94848791
91MP0002419_abnormal_innate_immunity0.94431547
92MP0005023_abnormal_wound_healing0.94283834
93MP0001835_abnormal_antigen_presentation0.93832954
94MP0001346_abnormal_lacrimal_gland0.91629079
95MP0003045_fibrosis0.91104297
96MP0005171_absent_coat_pigmentation0.90882524
97MP0003690_abnormal_glial_cell0.90097002
98MP0002998_abnormal_bone_remodeling0.89999123
99MP0000003_abnormal_adipose_tissue0.89433104
100MP0009384_cardiac_valve_regurgitation0.89061999
101MP0002136_abnormal_kidney_physiology0.87917546
102MP0008004_abnormal_stomach_pH0.87156663
103MP0001348_abnormal_lacrimal_gland0.86846960
104MP0002092_abnormal_eye_morphology0.86759096
105MP0001851_eye_inflammation0.85808543
106MP0000367_abnormal_coat/_hair0.84789766
107MP0001243_abnormal_dermal_layer0.83462381
108MP0005464_abnormal_platelet_physiology0.83173693
109MP0004084_abnormal_cardiac_muscle0.82231657
110MP0005503_abnormal_tendon_morphology0.81423480
111MP0001790_abnormal_immune_system0.80761161
112MP0005387_immune_system_phenotype0.80761161
113MP0003385_abnormal_body_wall0.80512535
114MP0000467_abnormal_esophagus_morphology0.80200553
115MP0008469_abnormal_protein_level0.80193353
116MP0002148_abnormal_hypersensitivity_rea0.79995236
117MP0010155_abnormal_intestine_physiology0.78578185
118MP0000569_abnormal_digit_pigmentation0.78536324
119MP0004130_abnormal_muscle_cell0.78406949
120MP0001845_abnormal_inflammatory_respons0.77483844
121MP0004197_abnormal_fetal_growth/weight/0.77105167
122MP0005000_abnormal_immune_tolerance0.77102690
123MP0001873_stomach_inflammation0.76957488
124MP0005319_abnormal_enzyme/_coenzyme0.76064349
125MP0005165_increased_susceptibility_to0.75780686
126MP0005670_abnormal_white_adipose0.75769639
127MP0005025_abnormal_response_to0.75728141
128MP0010630_abnormal_cardiac_muscle0.75165606
129MP0001756_abnormal_urination0.74899674
130* MP0004185_abnormal_adipocyte_glucose0.74208892
131MP0010368_abnormal_lymphatic_system0.73541422
132MP0000685_abnormal_immune_system0.73158791
133MP0000428_abnormal_craniofacial_morphol0.72477418
134MP0001958_emphysema0.72426216
135MP0003984_embryonic_growth_retardation0.72147405
136MP0000432_abnormal_head_morphology0.72086681
137MP0003172_abnormal_lysosome_physiology0.71873967
138MP0003091_abnormal_cell_migration0.71569491
139MP0003943_abnormal_hepatobiliary_system0.71259562
140MP0002925_abnormal_cardiovascular_devel0.71247989
141MP0003656_abnormal_erythrocyte_physiolo0.70129854
142MP0000465_gastrointestinal_hemorrhage0.69845222
143MP0001849_ear_inflammation0.69567377
144MP0002697_abnormal_eye_size0.68164868
145MP0005197_abnormal_uvea_morphology0.68023013
146MP0005187_abnormal_penis_morphology0.67251434
147MP0004087_abnormal_muscle_fiber0.66982868
148MP0002088_abnormal_embryonic_growth/wei0.66112114
149MP0001614_abnormal_blood_vessel0.65863106
150MP0005193_abnormal_anterior_eye0.65428494
151MP0009379_abnormal_foot_pigmentation0.64606353
152MP0001661_extended_life_span0.63833351
153MP0000858_altered_metastatic_potential0.62881679
154MP0002128_abnormal_blood_circulation0.62734184
155MP0001784_abnormal_fluid_regulation0.61822462

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.96554447
2Eczematoid dermatitis (HP:0000976)3.79929785
3Right ventricular cardiomyopathy (HP:0011663)3.69345750
4Increased IgE level (HP:0003212)3.69056694
5Subacute progressive viral hepatitis (HP:0006572)3.44557481
6Arterial tortuosity (HP:0005116)3.41532691
7Myocardial infarction (HP:0001658)3.40773695
8Xanthomatosis (HP:0000991)3.25997031
9Premature rupture of membranes (HP:0001788)3.24272382
10Vascular tortuosity (HP:0004948)3.11875118
11Deep venous thrombosis (HP:0002625)3.06539296
12Plantar hyperkeratosis (HP:0007556)3.03118163
13Vertebral arch anomaly (HP:0008438)2.94349682
14Ankyloglossia (HP:0010296)2.92229522
15Systemic lupus erythematosus (HP:0002725)2.89568858
16Intrahepatic cholestasis (HP:0001406)2.89061009
17Abnormality of glutamine family amino acid metabolism (HP:0010902)2.88574448
18Insomnia (HP:0100785)2.84965805
19Complement deficiency (HP:0004431)2.81513795
20Thick nail (HP:0001805)2.79632665
21Lip pit (HP:0100267)2.79238888
22Abnormality of proline metabolism (HP:0010907)2.69981865
23Hydroxyprolinuria (HP:0003080)2.69981865
24Palmoplantar hyperkeratosis (HP:0000972)2.69789755
25Congenital ichthyosiform erythroderma (HP:0007431)2.69454857
26Spinal cord lesions (HP:0100561)2.67921563
27Syringomyelia (HP:0003396)2.67921563
28Glomerulonephritis (HP:0000099)2.65922729
29Termporal pattern (HP:0011008)2.64662132
30Insidious onset (HP:0003587)2.64662132
31Papillary thyroid carcinoma (HP:0002895)2.59161527
32Vacuolated lymphocytes (HP:0001922)2.56487020
33Mucopolysacchariduria (HP:0008155)2.55432948
34Urinary glycosaminoglycan excretion (HP:0003541)2.55432948
35Increased cerebral lipofuscin (HP:0011813)2.54814322
36Hypotrichosis (HP:0001006)2.53951870
37Short nail (HP:0001799)2.53744897
38Nephritis (HP:0000123)2.51097656
39Abnormality of nail color (HP:0100643)2.50596975
40Palmar hyperkeratosis (HP:0010765)2.49827698
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48491247
42Flat acetabular roof (HP:0003180)2.47924982
43Dysostosis multiplex (HP:0000943)2.47349177
44Milia (HP:0001056)2.47122062
45Aortic aneurysm (HP:0004942)2.45328993
46Broad face (HP:0000283)2.43623757
47Axonal loss (HP:0003447)2.42965023
48Esophageal varix (HP:0002040)2.41984800
49Gangrene (HP:0100758)2.40272752
50Abnormality of complement system (HP:0005339)2.38344899
51Abnormality of polysaccharide metabolism (HP:0011012)2.37981855
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.37981855
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.37981855
54Abnormality of oral frenula (HP:0000190)2.36801315
55Amyloidosis (HP:0011034)2.36271023
56Aortic dissection (HP:0002647)2.36108582
57Fragile skin (HP:0001030)2.34750502
58Spondylolisthesis (HP:0003302)2.34389393
59Onycholysis (HP:0001806)2.34114640
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.33959446
61Woolly hair (HP:0002224)2.33753559
62Fat malabsorption (HP:0002630)2.33710197
63Epidermoid cyst (HP:0200040)2.30077233
64Wormian bones (HP:0002645)2.29829471
65Osteolytic defects of the hand bones (HP:0009699)2.29621371
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.29621371
67Hyporeflexia of lower limbs (HP:0002600)2.29595804
68Abnormality of the common coagulation pathway (HP:0010990)2.26569874
69Hematochezia (HP:0002573)2.25862205
70Hypoalphalipoproteinemia (HP:0003233)2.24344128
71Focal segmental glomerulosclerosis (HP:0000097)2.24210998
72Joint hemorrhage (HP:0005261)2.19771553
73Recurrent gram-negative bacterial infections (HP:0005420)2.18342835
74Increased neuronal autofluorescent lipopigment (HP:0002074)2.16324158
75Increased connective tissue (HP:0009025)2.13854049
76Atrophic scars (HP:0001075)2.13576441
77Vertebral compression fractures (HP:0002953)2.11807146
78Hyperlipoproteinemia (HP:0010980)2.11756833
79Cerebral aneurysm (HP:0004944)2.06161681
80Micronodular cirrhosis (HP:0001413)2.06066443
81Abnormality of the left ventricular outflow tract (HP:0011103)2.05678474
82Subaortic stenosis (HP:0001682)2.05678474
83Hypoglycemic coma (HP:0001325)2.05582154
84Recurrent bacterial skin infections (HP:0005406)2.04976638
85Periodontitis (HP:0000704)2.03066539
86Absent frontal sinuses (HP:0002688)2.02830682
87Hypercholesterolemia (HP:0003124)2.02155049
88Corneal erosion (HP:0200020)2.00728723
89Vascular calcification (HP:0004934)2.00147988
90Hyperglycinuria (HP:0003108)1.99684105
91Asymmetry of the thorax (HP:0001555)1.99105310
92Fragile nails (HP:0001808)1.98443022
93Conjunctival hamartoma (HP:0100780)1.97956778
94Ulnar bowing (HP:0003031)1.97678001
95Ectropion (HP:0000656)1.97340639
96Dehydration (HP:0001944)1.97064538
97Erythroderma (HP:0001019)1.96973063
98Increased CSF protein (HP:0002922)1.96657794
99Hyperacusis (HP:0010780)1.96235583
100Alopecia of scalp (HP:0002293)1.95830545
101Cardiovascular calcification (HP:0011915)1.95827450
102Acanthosis nigricans (HP:0000956)1.95325703
103Cervical subluxation (HP:0003308)1.95270506
104Curly hair (HP:0002212)1.95165036
105Distal lower limb amyotrophy (HP:0008944)1.94160229
106Cubitus valgus (HP:0002967)1.91766773
107Glomerulosclerosis (HP:0000096)1.91697103
108Overgrowth (HP:0001548)1.90483488
109Autoimmune thrombocytopenia (HP:0001973)1.89914035
110Abnormality of the gastric mucosa (HP:0004295)1.89564816
111Peritonitis (HP:0002586)1.89561209
112Missing ribs (HP:0000921)1.88610547
113Prolonged partial thromboplastin time (HP:0003645)1.87845442
114Relative macrocephaly (HP:0004482)1.86759361
115Steatorrhea (HP:0002570)1.86708644
116Mitral stenosis (HP:0001718)1.86608114
117Mitral valve prolapse (HP:0001634)1.83125488
118Diaphragmatic weakness (HP:0009113)1.82933624
119Selective tooth agenesis (HP:0001592)1.82922882
120Erythema (HP:0010783)1.82238966
121Coarse hair (HP:0002208)1.82101732
122Advanced eruption of teeth (HP:0006288)1.81203304
123Abnormality of sulfur amino acid metabolism (HP:0004339)1.80303303
124Ketosis (HP:0001946)1.80102273
125Hypolipoproteinemia (HP:0010981)1.80044297
126Hemorrhage of the eye (HP:0011885)1.80027464
127Neonatal short-limb short stature (HP:0008921)1.79884957
128Bladder diverticulum (HP:0000015)1.79571161
129Spinal rigidity (HP:0003306)1.79028713
130Aplasia cutis congenita (HP:0001057)1.78916004
131Abnormality of purine metabolism (HP:0004352)1.78852129
132Aneurysm (HP:0002617)1.78622308
133Hypoplasia of the iris (HP:0007676)1.78525458
134Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78250893
135Abnormality of the distal phalanx of the thumb (HP:0009617)1.78229364
136Tetraparesis (HP:0002273)1.77115671
137Interstitial pulmonary disease (HP:0006530)1.77080795
138Thin skin (HP:0000963)1.76008885
139Aplasia involving bones of the extremities (HP:0009825)1.75019263
140Aplasia involving bones of the upper limbs (HP:0009823)1.75019263
141Aplasia of the phalanges of the hand (HP:0009802)1.75019263
142Follicular hyperkeratosis (HP:0007502)1.74944274
143Neurofibrillary tangles (HP:0002185)1.74382902
144Mildly elevated creatine phosphokinase (HP:0008180)1.74063411
145Mitral regurgitation (HP:0001653)1.73574156
146Dilatation of the ascending aorta (HP:0005111)1.72969893
147Conjugated hyperbilirubinemia (HP:0002908)1.72389828
148Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72386462
149Gingival bleeding (HP:0000225)1.72369396
150Recurrent abscess formation (HP:0002722)1.72364240
151Abnormality of the acetabulum (HP:0003170)1.71914359
152Urticaria (HP:0001025)1.71868227
153Thin bony cortex (HP:0002753)1.71459983
154Orchitis (HP:0100796)1.71213059
155Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71160429
156Abnormality of the distal phalanges of the toes (HP:0010182)1.71159850
157Reduced subcutaneous adipose tissue (HP:0003758)1.71036584
158Pruritus (HP:0000989)1.70618781
159Abnormality of glycine metabolism (HP:0010895)1.70019606
160Abnormality of serine family amino acid metabolism (HP:0010894)1.70019606
161Scanning speech (HP:0002168)1.69530993
162Turricephaly (HP:0000262)1.69183789
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68985675
164Distal lower limb muscle weakness (HP:0009053)1.68544353
165Natal tooth (HP:0000695)1.68321392
166Soft skin (HP:0000977)1.68306292
167Deviation of the thumb (HP:0009603)1.67623483
168Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.66977994
169Abnormality of chloride homeostasis (HP:0011422)1.66787506
170Abnormal auditory evoked potentials (HP:0006958)1.65979934
171Bilateral sensorineural hearing impairment (HP:0008619)1.65596556
172Cerebral inclusion bodies (HP:0100314)1.65369939
173Hypopigmentation of the fundus (HP:0007894)1.64165287
174Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.63984902
175Elbow flexion contracture (HP:0002987)1.63412281
176Viral hepatitis (HP:0006562)1.62531751
177Renal cell carcinoma (HP:0005584)1.61026971
178Pili torti (HP:0003777)1.60435681
179Abnormal ossification of hand bones (HP:0005921)1.57535359
180Dysmetric saccades (HP:0000641)1.54449616
181Shallow orbits (HP:0000586)1.53264195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.68001790
2MST1R3.41136527
3EPHA23.18908559
4SCYL22.64851335
5LATS12.61947763
6STK392.61356979
7TRIB32.45320165
8TGFBR22.38180177
9RIPK12.20404681
10MAP3K142.04567466
11PTK61.99390045
12TBK11.99103689
13MAP3K31.95233396
14EPHB11.94591537
15LATS21.92632794
16ICK1.92001136
17FGFR41.90142984
18TYK21.88371087
19EEF2K1.86896280
20TAOK31.79657074
21MAP3K21.73376985
22SIK11.64590686
23ERBB31.63187599
24FRK1.59463542
25PBK1.50560598
26CAMK1D1.49697375
27JAK11.48857027
28PRPF4B1.45612532
29MET1.41365626
30MAPKAPK31.41081430
31IRAK31.40557251
32MAPK151.39465787
33BRD41.37822588
34BCKDK1.36528290
35PKN21.36057623
36AKT31.33849742
37BMX1.33440843
38INSRR1.32419050
39EPHA31.30517808
40FGFR31.28619570
41STK38L1.27044827
42FER1.24137178
43RIPK41.20808775
44MST41.20740938
45IKBKE1.20523082
46IKBKB1.17163459
47TTN1.14481402
48TRPM71.14217393
49PIK3CG1.11210565
50STK101.10684565
51JAK21.06988478
52MAP3K61.05500765
53PAK41.04725890
54PDGFRA1.04581898
55STK31.03011772
56PDGFRB0.97069000
57CDK60.95556243
58NEK90.95529702
59LRRK20.95423257
60CHUK0.93783847
61CAMK1G0.93092839
62NTRK10.92365010
63NEK60.92035333
64LMTK20.91583367
65MAP2K30.86462549
66EPHB20.84250358
67FGFR20.83628030
68JAK30.83287650
69PTK20.81969183
70MAP3K10.80734024
71MELK0.78646639
72CSK0.78190814
73GSK3A0.78055187
74PRKAA20.78026465
75DMPK0.76590381
76MAP3K70.73909016
77ERBB40.72750193
78DYRK1B0.71771076
79KIT0.71648062
80MAP2K20.71283662
81WNK40.69156584
82KSR10.66956904
83SGK30.66847661
84PNCK0.65398602
85BRSK20.65312901
86YES10.63853135
87STK380.63103566
88RET0.63039238
89ITK0.62859003
90ZAP700.60964210
91MAP2K10.59512429
92PRKD10.59247535
93FGFR10.56738426
94HCK0.56730337
95ABL10.56540666
96AKT20.55971418
97ROCK20.53840164
98EIF2AK30.53600295
99PAK20.52450414
100MAP3K120.51902365
101PDPK10.51155658
102MAP4K10.50788383
103EIF2AK10.50429804
104FLT30.50071990
105MAP3K130.49394369
106IGF1R0.49145279
107MAPK110.48959229
108DDR20.48257625
109PRKD30.48037003
110IRAK10.47235244
111BCR0.47213004
112MOS0.46965003
113KSR20.45874907
114BLK0.45090646
115SIK30.44855791
116BMPR20.44657316
117EGFR0.44647317
118TIE10.44401641
119ERBB20.44281100
120PIK3CA0.44249353
121HIPK20.43274039
122SMG10.42855280
123MAPKAPK20.42232297
124MYLK0.41975711
125RPS6KB20.41283105
126ABL20.41221834
127PRKCH0.41090657
128STK240.41019270
129CDK80.40748177
130WEE10.40740195
131MAP3K80.40201543
132WNK10.39969637
133TGFBR10.39692170
134CDK120.38570002
135EIF2AK20.38440845
136CDK90.37677882
137PRKG20.37012672
138CSF1R0.36686488
139MTOR0.36315426
140NEK20.32224803
141RPS6KB10.32072176
142PRKD20.30246119
143ROCK10.29371443
144MAPK100.27382074

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.73563645
2Staphylococcus aureus infection_Homo sapiens_hsa051502.22560808
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.15748888
4Chronic myeloid leukemia_Homo sapiens_hsa052202.00408556
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98844367
6Caffeine metabolism_Homo sapiens_hsa002321.95604556
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.91564540
8Fatty acid degradation_Homo sapiens_hsa000711.86391638
9Fat digestion and absorption_Homo sapiens_hsa049751.86210802
10Complement and coagulation cascades_Homo sapiens_hsa046101.81829681
11Thyroid cancer_Homo sapiens_hsa052161.81781747
12PPAR signaling pathway_Homo sapiens_hsa033201.68532490
13Renal cell carcinoma_Homo sapiens_hsa052111.64689920
14Arginine biosynthesis_Homo sapiens_hsa002201.55986617
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51267627
16ErbB signaling pathway_Homo sapiens_hsa040121.51141367
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49364313
18ABC transporters_Homo sapiens_hsa020101.47918971
19Tryptophan metabolism_Homo sapiens_hsa003801.42594212
20MicroRNAs in cancer_Homo sapiens_hsa052061.42016418
21Histidine metabolism_Homo sapiens_hsa003401.41497971
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40415421
23Endometrial cancer_Homo sapiens_hsa052131.39917009
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38805892
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37097643
26Non-small cell lung cancer_Homo sapiens_hsa052231.34889444
27Bile secretion_Homo sapiens_hsa049761.33350028
28Bladder cancer_Homo sapiens_hsa052191.27698547
29Glioma_Homo sapiens_hsa052141.27455408
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.26736395
31Protein digestion and absorption_Homo sapiens_hsa049741.25632625
32Fatty acid metabolism_Homo sapiens_hsa012121.25226258
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.23988326
34Lysosome_Homo sapiens_hsa041421.23493023
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22988023
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22043776
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19650560
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.18958736
39Inositol phosphate metabolism_Homo sapiens_hsa005621.18598955
40Sulfur metabolism_Homo sapiens_hsa009201.18388217
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17128623
42VEGF signaling pathway_Homo sapiens_hsa043701.15478111
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.14537114
44Prostate cancer_Homo sapiens_hsa052151.12482472
45Pancreatic secretion_Homo sapiens_hsa049721.11946664
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11509522
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08502141
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.08022049
49Hippo signaling pathway_Homo sapiens_hsa043901.07469383
50beta-Alanine metabolism_Homo sapiens_hsa004101.06846962
51Leishmaniasis_Homo sapiens_hsa051401.06117047
52Chemical carcinogenesis_Homo sapiens_hsa052041.06031117
53Propanoate metabolism_Homo sapiens_hsa006401.05750482
54Starch and sucrose metabolism_Homo sapiens_hsa005001.05708106
55Melanogenesis_Homo sapiens_hsa049161.05536247
56Vitamin digestion and absorption_Homo sapiens_hsa049771.05487329
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03852542
58Osteoclast differentiation_Homo sapiens_hsa043801.03133770
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02991723
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.01452363
61Glycerolipid metabolism_Homo sapiens_hsa005611.01035545
62Adipocytokine signaling pathway_Homo sapiens_hsa049201.00731771
63Retinol metabolism_Homo sapiens_hsa008301.00164727
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99959158
65Prion diseases_Homo sapiens_hsa050200.99385984
66Choline metabolism in cancer_Homo sapiens_hsa052310.98881035
67Pathways in cancer_Homo sapiens_hsa052000.98568470
68Peroxisome_Homo sapiens_hsa041460.97197321
69GnRH signaling pathway_Homo sapiens_hsa049120.97000022
70Other glycan degradation_Homo sapiens_hsa005110.96778717
71mTOR signaling pathway_Homo sapiens_hsa041500.96759860
72Insulin resistance_Homo sapiens_hsa049310.95771721
73Amoebiasis_Homo sapiens_hsa051460.93241150
74Toxoplasmosis_Homo sapiens_hsa051450.91545632
75Circadian rhythm_Homo sapiens_hsa047100.90832772
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.90628744
77Acute myeloid leukemia_Homo sapiens_hsa052210.90149169
78Phenylalanine metabolism_Homo sapiens_hsa003600.89910051
79Insulin signaling pathway_Homo sapiens_hsa049100.89620160
80Endocytosis_Homo sapiens_hsa041440.89186193
81Estrogen signaling pathway_Homo sapiens_hsa049150.88756966
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87246690
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86161025
84Pertussis_Homo sapiens_hsa051330.84434459
85Mineral absorption_Homo sapiens_hsa049780.84205156
86Prolactin signaling pathway_Homo sapiens_hsa049170.83621538
87Tight junction_Homo sapiens_hsa045300.83267141
88Long-term potentiation_Homo sapiens_hsa047200.82790329
89Colorectal cancer_Homo sapiens_hsa052100.82624607
90Fatty acid biosynthesis_Homo sapiens_hsa000610.81354238
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81353827
92TGF-beta signaling pathway_Homo sapiens_hsa043500.81029055
93Rap1 signaling pathway_Homo sapiens_hsa040150.79873398
94Fatty acid elongation_Homo sapiens_hsa000620.79280534
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.79008642
96Gap junction_Homo sapiens_hsa045400.78452223
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77951584
98Renin-angiotensin system_Homo sapiens_hsa046140.77864411
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77858982
100Sphingolipid metabolism_Homo sapiens_hsa006000.77755109
101TNF signaling pathway_Homo sapiens_hsa046680.77439497
102Melanoma_Homo sapiens_hsa052180.77163523
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75023803
104Malaria_Homo sapiens_hsa051440.74593096
105Shigellosis_Homo sapiens_hsa051310.74318935
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73171422
107Notch signaling pathway_Homo sapiens_hsa043300.73162366
108Butanoate metabolism_Homo sapiens_hsa006500.72859994
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72416098
110Dilated cardiomyopathy_Homo sapiens_hsa054140.72233716
111Adherens junction_Homo sapiens_hsa045200.72137095
112ECM-receptor interaction_Homo sapiens_hsa045120.72119133
113Steroid biosynthesis_Homo sapiens_hsa001000.71418993
114FoxO signaling pathway_Homo sapiens_hsa040680.71186219
115Hepatitis C_Homo sapiens_hsa051600.70578302
116Tuberculosis_Homo sapiens_hsa051520.70036570
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.69113753
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68957307
119AMPK signaling pathway_Homo sapiens_hsa041520.68523887
120Lysine degradation_Homo sapiens_hsa003100.68486612
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68262593
122Hedgehog signaling pathway_Homo sapiens_hsa043400.67155029
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63915853
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63608544
125Hepatitis B_Homo sapiens_hsa051610.63019108
126Ras signaling pathway_Homo sapiens_hsa040140.62853640
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61540749
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60997298
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.60497301
130Proteoglycans in cancer_Homo sapiens_hsa052050.60143840
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58189943
132Wnt signaling pathway_Homo sapiens_hsa043100.57794596
133Dorso-ventral axis formation_Homo sapiens_hsa043200.57658693
134p53 signaling pathway_Homo sapiens_hsa041150.57058478
135Influenza A_Homo sapiens_hsa051640.56637357
136Legionellosis_Homo sapiens_hsa051340.56302690
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55970906
138Linoleic acid metabolism_Homo sapiens_hsa005910.55610083
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55254330
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55177205
141Basal cell carcinoma_Homo sapiens_hsa052170.55165872
142Selenocompound metabolism_Homo sapiens_hsa004500.54298317
143Tyrosine metabolism_Homo sapiens_hsa003500.53791319
144Folate biosynthesis_Homo sapiens_hsa007900.53611326
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53466988
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.52751811
147Axon guidance_Homo sapiens_hsa043600.52085955
148Thyroid hormone synthesis_Homo sapiens_hsa049180.51788808
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51642420
150Salmonella infection_Homo sapiens_hsa051320.50195622
151Small cell lung cancer_Homo sapiens_hsa052220.50063015
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49513904
153Focal adhesion_Homo sapiens_hsa045100.48710072
154Viral carcinogenesis_Homo sapiens_hsa052030.48604445
155Graft-versus-host disease_Homo sapiens_hsa053320.47419463
156RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46592371
157Jak-STAT signaling pathway_Homo sapiens_hsa046300.46412688
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43042049
159Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42567393
160Type II diabetes mellitus_Homo sapiens_hsa049300.41347856
161Apoptosis_Homo sapiens_hsa042100.41048895
162Arachidonic acid metabolism_Homo sapiens_hsa005900.39382471
163Platelet activation_Homo sapiens_hsa046110.38414406
164Pancreatic cancer_Homo sapiens_hsa052120.38070558
165African trypanosomiasis_Homo sapiens_hsa051430.38043736
166B cell receptor signaling pathway_Homo sapiens_hsa046620.37887323
167Measles_Homo sapiens_hsa051620.37511715

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