SSH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.06159693
2negative regulation of cell killing (GO:0031342)5.05360855
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05360855
4tolerance induction (GO:0002507)4.68279881
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66609080
6positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.62745915
7antigen processing and presentation of endogenous antigen (GO:0019883)4.61546155
8G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.59853674
9detection of other organism (GO:0098543)4.54631026
10positive regulation of gamma-delta T cell activation (GO:0046645)4.38839091
11neutrophil activation involved in immune response (GO:0002283)4.34746325
12detection of external biotic stimulus (GO:0098581)4.34403466
13regulation of B cell receptor signaling pathway (GO:0050855)4.30572185
14negative regulation of lymphocyte mediated immunity (GO:0002707)4.18021809
15cilium or flagellum-dependent cell motility (GO:0001539)4.17285736
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.14649643
17response to host immune response (GO:0052572)4.11684170
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.11684170
19detection of bacterium (GO:0016045)4.05429114
20response to peptidoglycan (GO:0032494)4.02373817
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01994531
22positive thymic T cell selection (GO:0045059)4.00061360
23negative regulation of interleukin-12 production (GO:0032695)3.99276127
24negative regulation of T cell mediated immunity (GO:0002710)3.97527937
25neutrophil mediated immunity (GO:0002446)3.89561025
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.85375167
27response to host (GO:0075136)3.85375167
28response to host defenses (GO:0052200)3.85375167
29microglial cell activation (GO:0001774)3.85142933
30positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.84434526
31positive T cell selection (GO:0043368)3.83654657
32detection of biotic stimulus (GO:0009595)3.78213264
33activated T cell proliferation (GO:0050798)3.75678560
34negative regulation of granulocyte differentiation (GO:0030853)3.72275471
35interferon-gamma production (GO:0032609)3.71715235
36cellular response to interleukin-15 (GO:0071350)3.67701117
37respiratory burst (GO:0045730)3.63978087
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.61130563
39myeloid cell activation involved in immune response (GO:0002275)3.60613565
40negative regulation of leukocyte mediated immunity (GO:0002704)3.57013967
41cellular extravasation (GO:0045123)3.56099244
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.46301294
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.44806800
44myeloid leukocyte mediated immunity (GO:0002444)3.44501367
45response to interleukin-15 (GO:0070672)3.43376105
46mature B cell differentiation (GO:0002335)3.41396475
47regulation of gamma-delta T cell differentiation (GO:0045586)3.38582255
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37260264
49leukocyte migration involved in inflammatory response (GO:0002523)3.34010611
50production of molecular mediator involved in inflammatory response (GO:0002532)3.32880123
51granulocyte activation (GO:0036230)3.29562606
52regulation of T cell tolerance induction (GO:0002664)3.26528785
53immunoglobulin mediated immune response (GO:0016064)3.26160834
54germinal center formation (GO:0002467)3.25370305
55negative regulation of T-helper cell differentiation (GO:0045623)3.17491144
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17491144
57regulation of gamma-delta T cell activation (GO:0046643)3.17390758
58antigen processing and presentation via MHC class Ib (GO:0002475)3.17153609
59negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15558165
60purinergic nucleotide receptor signaling pathway (GO:0035590)3.13962590
61positive regulation of mast cell activation (GO:0033005)3.13626179
62negative T cell selection (GO:0043383)3.13201317
63B cell receptor signaling pathway (GO:0050853)3.12034558
64regulation of mast cell degranulation (GO:0043304)3.09515314
65defense response to protozoan (GO:0042832)3.07571336
66regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.06529130
67positive regulation of granulocyte differentiation (GO:0030854)3.05749099
68T cell selection (GO:0045058)3.01399136
69dendritic cell migration (GO:0036336)2.98872755
70negative thymic T cell selection (GO:0045060)2.98504001
71negative regulation of translation, ncRNA-mediated (GO:0040033)2.97575548
72regulation of translation, ncRNA-mediated (GO:0045974)2.97575548
73negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97575548
74regulation of mast cell activation (GO:0033003)2.97438095
75thymic T cell selection (GO:0045061)2.97364796
76positive regulation by symbiont of host defense response (GO:0052509)2.96817901
77modulation by symbiont of host defense response (GO:0052031)2.96817901
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96817901
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96817901
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.96817901
81modulation by symbiont of host immune response (GO:0052553)2.96817901
82regulation of alpha-beta T cell proliferation (GO:0046640)2.96224365
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93452617
84histone H3-K4 trimethylation (GO:0080182)2.93335774
85negative regulation of adaptive immune response (GO:0002820)2.92966060
86regulation of mast cell activation involved in immune response (GO:0033006)2.92689697
87positive regulation of interferon-alpha production (GO:0032727)2.92639294
88regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91739840
89T cell migration (GO:0072678)2.91217887
90type I interferon signaling pathway (GO:0060337)2.90653103
91cellular response to type I interferon (GO:0071357)2.90653103
92response to type I interferon (GO:0034340)2.90468784
93positive regulation of B cell differentiation (GO:0045579)2.89523771
94regulation of interleukin-12 biosynthetic process (GO:0045075)2.87595553
95leukocyte degranulation (GO:0043299)2.87204054
96positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87085803
97leukocyte aggregation (GO:0070486)2.86829286
98antigen receptor-mediated signaling pathway (GO:0050851)2.86262288
99negative regulation of erythrocyte differentiation (GO:0045647)2.85358293
100G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.84527301
101macrophage activation involved in immune response (GO:0002281)2.80255505
102myeloid leukocyte activation (GO:0002274)2.79896130
103B cell homeostasis (GO:0001782)2.78815700
104regulation of germinal center formation (GO:0002634)2.78766365
105interferon-gamma-mediated signaling pathway (GO:0060333)2.77786594
106RNA destabilization (GO:0050779)2.75471819
107regulation of granulocyte differentiation (GO:0030852)2.75414352
108T cell receptor signaling pathway (GO:0050852)2.75076334
109regulation of necroptotic process (GO:0060544)2.74508724
110negative regulation of B cell proliferation (GO:0030889)2.73094502
111regulation of B cell differentiation (GO:0045577)2.72118844
112positive regulation of tolerance induction (GO:0002645)2.70826679
113regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.67265574
114positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.67265574
115regulation of tolerance induction (GO:0002643)2.65786382
116negative regulation of execution phase of apoptosis (GO:1900118)2.61122439
117regulation of interferon-beta biosynthetic process (GO:0045357)2.59016570
118positive regulation of chemokine secretion (GO:0090197)2.58994545
119acrosome assembly (GO:0001675)2.58629891
120positive regulation of B cell proliferation (GO:0030890)2.56452741
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54921494
122mast cell activation (GO:0045576)2.54691279
123regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.54288700
124positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.54288700
125epithelial cilium movement (GO:0003351)2.54282930
126regulation of interleukin-2 biosynthetic process (GO:0045076)2.52044884
127response to muramyl dipeptide (GO:0032495)2.50878677
128regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.47675200
129axonemal dynein complex assembly (GO:0070286)2.45090262
130multicellular organism reproduction (GO:0032504)2.43546959
131interkinetic nuclear migration (GO:0022027)2.42895226
132presynaptic membrane assembly (GO:0097105)2.42545329
133regulation of B cell proliferation (GO:0030888)2.42503493
134adaptation of signaling pathway (GO:0023058)2.42420228
135regulation of cytokine production involved in inflammatory response (GO:1900015)2.42237482
136macrophage activation (GO:0042116)2.38545204
137fusion of sperm to egg plasma membrane (GO:0007342)2.36161623
138negative regulation of interleukin-6 production (GO:0032715)2.35919155
139lymphocyte homeostasis (GO:0002260)2.35610742
140negative regulation of inclusion body assembly (GO:0090084)2.35486737
141T cell costimulation (GO:0031295)2.35095756
142T cell homeostasis (GO:0043029)2.34962430
143purinergic receptor signaling pathway (GO:0035587)2.34210358
144CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.33803672
145T-helper cell differentiation (GO:0042093)2.33803672
146cilium movement (GO:0003341)2.33331208
147regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32119899
148piRNA metabolic process (GO:0034587)2.31861467
149DNA methylation involved in gamete generation (GO:0043046)2.31762363
150lymphocyte costimulation (GO:0031294)2.30796695
151alpha-beta T cell differentiation (GO:0046632)2.27349278
152regulation of natural killer cell mediated immunity (GO:0002715)2.27050826
153regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.27050826
154alpha-beta T cell activation (GO:0046631)2.26000477
155neutrophil activation (GO:0042119)2.25967473
156negative regulation of bone resorption (GO:0045779)2.23732192
157lymph node development (GO:0048535)2.23537933
158regulation of regulatory T cell differentiation (GO:0045589)2.22976415
159positive regulation of B cell activation (GO:0050871)2.22659507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.78507084
2EZH2_22144423_ChIP-Seq_EOC_Human4.56636211
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.52266387
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31637498
5MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80883197
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.58179069
7RUNX_20019798_ChIP-Seq_JUKART_Human2.48415236
8SPI1_23547873_ChIP-Seq_NB4_Human2.35269898
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.28341018
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20322869
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.17835702
12GBX2_23144817_ChIP-Seq_PC3_Human2.04524330
13* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.02173414
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.01373755
15VDR_21846776_ChIP-Seq_THP-1_Human1.97610993
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93657555
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92944126
18* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92709434
19GATA3_27048872_Chip-Seq_THYMUS_Human1.90398799
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88076511
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.87893091
22* RUNX1_22412390_ChIP-Seq_EML_Mouse1.86485225
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.84466670
24MYC_22102868_ChIP-Seq_BL_Human1.84461852
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.82314711
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80107890
27TCF7_22412390_ChIP-Seq_EML_Mouse1.75819133
28SCL_19346495_ChIP-Seq_HPC-7_Human1.74695264
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71334294
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69808501
31GATA1_19941827_ChIP-Seq_MEL_Mouse1.63966978
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63283874
33TAF15_26573619_Chip-Seq_HEK293_Human1.61407864
34GATA1_22025678_ChIP-Seq_K562_Human1.59103355
35VDR_24787735_ChIP-Seq_THP-1_Human1.57213863
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.57159528
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56880073
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56212249
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55767292
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53798372
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53307978
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50075148
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.49174958
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47188991
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46399709
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46390919
47GATA3_26560356_Chip-Seq_TH2_Human1.45919412
48KDM2B_26808549_Chip-Seq_DND41_Human1.43867644
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43249025
50* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42453719
51AR_21572438_ChIP-Seq_LNCaP_Human1.42342337
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41807501
53MAF_26560356_Chip-Seq_TH2_Human1.40481186
54* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36885675
55MYB_26560356_Chip-Seq_TH2_Human1.36204173
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35868676
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35668517
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.35185895
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32593677
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32452364
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30523962
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29985473
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29791686
64* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29636968
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27314345
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27018919
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.26264907
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.26167480
69* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25658781
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25420031
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.25049371
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25030381
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24914377
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24057710
75GATA1_19941826_ChIP-Seq_K562_Human1.21522501
76* DROSHA_22980978_ChIP-Seq_HELA_Human1.19343235
77* SPI1_23127762_ChIP-Seq_K562_Human1.16787920
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16374607
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15759032
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14775183
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.14738149
82SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13712806
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13709497
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13709497
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13487611
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12837520
87VDR_22108803_ChIP-Seq_LS180_Human1.11367334
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.11176521
89P300_18555785_Chip-Seq_ESCs_Mouse1.11013897
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10361212
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10238811
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09660057
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.09195895
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09066425
95* GATA2_19941826_ChIP-Seq_K562_Human1.08376126
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08250217
97P53_22387025_ChIP-Seq_ESCs_Mouse1.07987403
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07525963
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07476771
100MYB_26560356_Chip-Seq_TH1_Human1.07383728
101* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06271310
102* MAF_26560356_Chip-Seq_TH1_Human1.05329538
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.04696385
104OCT4_18555785_Chip-Seq_ESCs_Mouse1.03575109
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.03184656
106P300_19829295_ChIP-Seq_ESCs_Human1.02505901
107AHR_22903824_ChIP-Seq_MCF-7_Human1.02084134
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.01081286
109SMAD4_21799915_ChIP-Seq_A2780_Human1.00908446
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00889521
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00723343
112VDR_24763502_ChIP-Seq_THP-1_Human0.99824728
113GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99788585
114ARNT_22903824_ChIP-Seq_MCF-7_Human0.99584242
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99287425
116KDM2B_26808549_Chip-Seq_REH_Human0.99067636
117* PU_27001747_Chip-Seq_BMDM_Mouse0.98966352
118TP53_16413492_ChIP-PET_HCT116_Human0.98851056
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98534413
120PU1_27457419_Chip-Seq_LIVER_Mouse0.98449334
121* TCF4_23295773_ChIP-Seq_U87_Human0.97542982
122* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95389281
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94793572
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94711961
125STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94699257
126SMRT_27268052_Chip-Seq_Bcells_Human0.94653451
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.93875821
128* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93731942
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93617666
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.93160568
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93150048
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.92134476
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92019303
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91153573
135* ER_23166858_ChIP-Seq_MCF-7_Human0.91128338
136* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90960059
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.90759810
138ZFX_18555785_Chip-Seq_ESCs_Mouse0.90744444
139IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90509067
140KLF4_18555785_Chip-Seq_ESCs_Mouse0.90116536
141* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90067946
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.89896414
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89762205
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.89468533
145* UTX_26944678_Chip-Seq_JUKART_Human0.88817342
146* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88145270
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84915010
148SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84155140
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.82999055
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80437085
151* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78406525
152* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78406078
153* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76184658
154KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75201089
155RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74959885
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74907089
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.74659199
158* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74111992
159* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73147061
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72968945
161* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.68094228
162FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.67349802
163CIITA_25753668_ChIP-Seq_RAJI_Human0.61876734
164TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.61268167

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color4.04967553
2MP0005671_abnormal_response_to3.12914394
3MP0003136_yellow_coat_color3.02244223
4MP0003724_increased_susceptibility_to2.96543356
5MP0004381_abnormal_hair_follicle2.92184200
6MP0003303_peritoneal_inflammation2.76072942
7MP0001800_abnormal_humoral_immune2.62085125
8MP0001835_abnormal_antigen_presentation2.60355053
9MP0003763_abnormal_thymus_physiology2.57613468
10MP0001188_hyperpigmentation2.54108937
11MP0008260_abnormal_autophagy2.51481460
12MP0005387_immune_system_phenotype2.41284511
13MP0001790_abnormal_immune_system2.41284511
14MP0005174_abnormal_tail_pigmentation2.38533852
15MP0000015_abnormal_ear_pigmentation2.36092815
16MP0005410_abnormal_fertilization2.35215847
17MP0005451_abnormal_body_composition2.29042398
18MP0005000_abnormal_immune_tolerance2.27029333
19MP0002723_abnormal_immune_serum2.25309026
20MP0002452_abnormal_antigen_presenting2.24240099
21MP0004510_myositis2.18882118
22MP0003828_pulmonary_edema2.18819568
23MP0002420_abnormal_adaptive_immunity2.08553000
24MP0001819_abnormal_immune_cell2.06490938
25MP0003436_decreased_susceptibility_to1.99895445
26MP0002419_abnormal_innate_immunity1.96973662
27MP0000685_abnormal_immune_system1.89800514
28MP0003045_fibrosis1.81263709
29MP0003172_abnormal_lysosome_physiology1.80833182
30MP0005025_abnormal_response_to1.80759500
31MP0001853_heart_inflammation1.76982337
32MP0002148_abnormal_hypersensitivity_rea1.74266615
33MP0009785_altered_susceptibility_to1.72657003
34MP0002166_altered_tumor_susceptibility1.72560487
35MP0002398_abnormal_bone_marrow1.65433142
36MP0000716_abnormal_immune_system1.65390494
37MP0005670_abnormal_white_adipose1.64512121
38MP0002396_abnormal_hematopoietic_system1.63481968
39MP0002405_respiratory_system_inflammati1.59997982
40MP0006082_CNS_inflammation1.57184104
41MP0001851_eye_inflammation1.56152632
42MP0002132_abnormal_respiratory_system1.55841662
43MP0002277_abnormal_respiratory_mucosa1.52274525
44MP0005464_abnormal_platelet_physiology1.51250917
45MP0000465_gastrointestinal_hemorrhage1.49627537
46MP0003300_gastrointestinal_ulcer1.48901837
47MP0002933_joint_inflammation1.48626847
48MP0003183_abnormal_peptide_metabolism1.46679186
49MP0008995_early_reproductive_senescence1.45999605
50MP0000703_abnormal_thymus_morphology1.38637886
51MP0003866_abnormal_defecation1.32247174
52MP0009764_decreased_sensitivity_to1.29144648
53MP0002009_preneoplasia1.26685360
54MP0000689_abnormal_spleen_morphology1.26602684
55MP0003656_abnormal_erythrocyte_physiolo1.25979129
56MP0001873_stomach_inflammation1.25714830
57MP0005397_hematopoietic_system_phenotyp1.21399661
58MP0001545_abnormal_hematopoietic_system1.21399661
59MP0002332_abnormal_exercise_endurance1.20877471
60MP0003787_abnormal_imprinting1.20000823
61MP0002722_abnormal_immune_system1.19047731
62MP0005164_abnormal_response_to1.17834129
63MP0005075_abnormal_melanosome_morpholog1.17421771
64MP0003221_abnormal_cardiomyocyte_apopto1.16882437
65MP0003690_abnormal_glial_cell1.15998609
66MP0000858_altered_metastatic_potential1.15993665
67MP0002006_tumorigenesis1.15730728
68MP0002429_abnormal_blood_cell1.14795397
69MP0002095_abnormal_skin_pigmentation1.10851398
70MP0000920_abnormal_myelination1.10488646
71MP0001533_abnormal_skeleton_physiology1.09797684
72MP0001845_abnormal_inflammatory_respons1.09184764
73MP0002998_abnormal_bone_remodeling1.08140824
74MP0010155_abnormal_intestine_physiology1.07599339
75MP0004808_abnormal_hematopoietic_stem1.07237805
76MP0004484_altered_response_of1.06910018
77MP0008877_abnormal_DNA_methylation1.06702205
78MP0009278_abnormal_bone_marrow1.06333370
79MP0008057_abnormal_DNA_replication1.02903556
80MP0003646_muscle_fatigue1.00266650
81MP0000569_abnormal_digit_pigmentation1.00131883
82MP0000751_myopathy0.95708500
83MP0003191_abnormal_cellular_cholesterol0.95270842
84MP0009333_abnormal_splenocyte_physiolog0.94129219
85MP0004742_abnormal_vestibular_system0.93168156
86MP0009379_abnormal_foot_pigmentation0.92757373
87MP0005666_abnormal_adipose_tissue0.87926200
88MP0003091_abnormal_cell_migration0.86563264
89MP0002928_abnormal_bile_duct0.84642463
90MP0006292_abnormal_olfactory_placode0.84206387
91MP0003698_abnormal_male_reproductive0.83026444
92MP0003880_abnormal_central_pattern0.82643714
93MP0003075_altered_response_to0.82301012
94MP0005166_decreased_susceptibility_to0.78857428
95MP0000249_abnormal_blood_vessel0.76129601
96MP0000343_altered_response_to0.75803141
97MP0002102_abnormal_ear_morphology0.75195288
98MP0008469_abnormal_protein_level0.74618362
99MP0001986_abnormal_taste_sensitivity0.73691450
100MP0003448_altered_tumor_morphology0.73340955
101MP0009763_increased_sensitivity_to0.70392834
102MP0001663_abnormal_digestive_system0.70263529
103MP0004883_abnormal_blood_vessel0.69845004
104MP0005645_abnormal_hypothalamus_physiol0.69839385
105MP0008961_abnormal_basal_metabolism0.69293429
106MP0005423_abnormal_somatic_nervous0.67516212
107MP0001929_abnormal_gametogenesis0.67283052
108MP0002138_abnormal_hepatobiliary_system0.66061021
109MP0004185_abnormal_adipocyte_glucose0.65748538
110MP0001879_abnormal_lymphatic_vessel0.65731604
111MP0000604_amyloidosis0.64445167
112MP0003941_abnormal_skin_development0.62538625
113MP0005310_abnormal_salivary_gland0.61924563
114MP0004145_abnormal_muscle_electrophysio0.60418497
115MP0005376_homeostasis/metabolism_phenot0.60046022
116MP0004130_abnormal_muscle_cell0.59471247
117MP0001486_abnormal_startle_reflex0.59438533
118MP0002133_abnormal_respiratory_system0.57195626
119MP0005388_respiratory_system_phenotype0.57195626
120MP0004947_skin_inflammation0.57154159
121MP0000749_muscle_degeneration0.57130762
122MP0008004_abnormal_stomach_pH0.57087043
123MP0008874_decreased_physiological_sensi0.56700777
124MP0005390_skeleton_phenotype0.56632919
125MP0009765_abnormal_xenobiotic_induced0.55994109
126MP0002971_abnormal_brown_adipose0.55515275
127MP0000767_abnormal_smooth_muscle0.55169319
128MP0009115_abnormal_fat_cell0.54397110
129MP0000371_diluted_coat_color0.53808039

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)4.84277226
2Absent/shortened dynein arms (HP:0200106)4.84277226
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.67750943
4Recurrent gram-negative bacterial infections (HP:0005420)4.25587701
5Gastrointestinal infarctions (HP:0005244)4.25015328
6Abnormality of macrophages (HP:0004311)4.24850941
7Agammaglobulinemia (HP:0004432)3.99050959
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.82794156
9Recurrent sinusitis (HP:0011108)3.55442654
10Chronic mucocutaneous candidiasis (HP:0002728)3.49842617
11Recurrent cutaneous fungal infections (HP:0011370)3.49842617
12Chest pain (HP:0100749)3.44695551
13Recurrent fungal infections (HP:0002841)3.41480321
14Chronic diarrhea (HP:0002028)3.37369707
15Nasal polyposis (HP:0100582)3.27941160
16Glomerulonephritis (HP:0000099)3.26495472
17Recurrent abscess formation (HP:0002722)3.25137537
18Panhypogammaglobulinemia (HP:0003139)3.24915472
19Abnormal respiratory motile cilium physiology (HP:0012261)3.24523022
20Stomatitis (HP:0010280)3.24122221
21Meningitis (HP:0001287)3.22444565
22Gingival bleeding (HP:0000225)3.22071207
23Inflammation of the large intestine (HP:0002037)3.17594330
24Abnormality of the fingertips (HP:0001211)3.15567036
25Peritonitis (HP:0002586)3.11035133
26Eczematoid dermatitis (HP:0000976)3.10735033
27Abnormal ciliary motility (HP:0012262)3.08635543
28Recurrent bronchitis (HP:0002837)3.08151127
29Systemic lupus erythematosus (HP:0002725)3.05434253
30Thyroiditis (HP:0100646)3.04216437
31Abnormality of the nasal mucosa (HP:0000433)3.02583242
32Colitis (HP:0002583)3.00325885
33Retrobulbar optic neuritis (HP:0100654)2.97970012
34Optic neuritis (HP:0100653)2.97970012
35Urticaria (HP:0001025)2.96111037
36Increased IgE level (HP:0003212)2.94470413
37Obstructive lung disease (HP:0006536)2.92875677
38Chronic obstructive pulmonary disease (HP:0006510)2.92875677
39IgM deficiency (HP:0002850)2.90863808
40Abnormal respiratory epithelium morphology (HP:0012253)2.90505351
41Abnormal respiratory motile cilium morphology (HP:0005938)2.90505351
42Myositis (HP:0100614)2.87198657
43Epistaxis (HP:0000421)2.81672891
44Gastrointestinal inflammation (HP:0004386)2.74531182
45Spontaneous hematomas (HP:0007420)2.73901790
46Recurrent viral infections (HP:0004429)2.73727001
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.67481648
48Bronchiectasis (HP:0002110)2.65996846
49Episodic fever (HP:0001954)2.63861593
50Eosinophilia (HP:0001880)2.62518263
51Hypochromic microcytic anemia (HP:0004840)2.62304398
52Subacute progressive viral hepatitis (HP:0006572)2.61863929
53T lymphocytopenia (HP:0005403)2.61744768
54Recurrent bacterial skin infections (HP:0005406)2.58014779
55Difficulty running (HP:0009046)2.57681004
56Pulmonary embolism (HP:0002204)2.57530467
57Rhinitis (HP:0012384)2.57264294
58Pustule (HP:0200039)2.55994036
59Viral hepatitis (HP:0006562)2.48769420
60Orchitis (HP:0100796)2.48458060
61Recurrent skin infections (HP:0001581)2.47805943
62Abnormality of T cell number (HP:0011839)2.44985898
63Slow saccadic eye movements (HP:0000514)2.44181277
64Hypochromic anemia (HP:0001931)2.43872279
65Abnormality of eosinophils (HP:0001879)2.43667388
66Anorexia (HP:0002039)2.42300394
67Abnormality of B cell number (HP:0010975)2.42172386
68B lymphocytopenia (HP:0010976)2.42172386
69Severe combined immunodeficiency (HP:0004430)2.42011249
70Muscle hypertrophy of the lower extremities (HP:0008968)2.41460563
71Cellulitis (HP:0100658)2.37180911
72Vasculitis (HP:0002633)2.35960641
73Abnormality of the peritoneum (HP:0002585)2.35670807
74Abnormality of the endocardium (HP:0004306)2.32524802
75Elevated erythrocyte sedimentation rate (HP:0003565)2.31196577
76Bronchitis (HP:0012387)2.30580572
77Recurrent otitis media (HP:0000403)2.30323287
78Abnormality of the axillary hair (HP:0100134)2.28127241
79Abnormality of secondary sexual hair (HP:0009888)2.28127241
80Abnormality of T cell physiology (HP:0011840)2.24565192
81Hemoptysis (HP:0002105)2.21410974
82Mediastinal lymphadenopathy (HP:0100721)2.21156115
83Sepsis (HP:0100806)2.16742476
84Leukocytosis (HP:0001974)2.16508291
85Gangrene (HP:0100758)2.14582569
86Acute hepatic failure (HP:0006554)2.14285508
87Abnormality of the pleura (HP:0002103)2.14000554
88Prolonged bleeding time (HP:0003010)2.13990446
89Microcytic anemia (HP:0001935)2.12638468
90Obstructive sleep apnea (HP:0002870)2.10831020
91Calf muscle hypertrophy (HP:0008981)2.08630710
92Prostate neoplasm (HP:0100787)2.08238015
93Chronic otitis media (HP:0000389)2.05788989
94Autoimmune hemolytic anemia (HP:0001890)2.05786136
95Chronic sinusitis (HP:0011109)2.02799794
96Gastrointestinal stroma tumor (HP:0100723)2.01150835
97Amyloidosis (HP:0011034)2.00876424
98Vertigo (HP:0002321)2.00588205
99Widely spaced teeth (HP:0000687)1.98879249
100Aplasia cutis congenita (HP:0001057)1.98450132
101Disproportionate tall stature (HP:0001519)1.97310980
102Cheilitis (HP:0100825)1.96890489
103Abnormality of T cells (HP:0002843)1.96180883
104Recurrent pneumonia (HP:0006532)1.95387175
105Increased IgM level (HP:0003496)1.95096590
106Arterial tortuosity (HP:0005116)1.91781897
107Keratoconjunctivitis sicca (HP:0001097)1.91390927
108Hematochezia (HP:0002573)1.91312573
109Keratitis (HP:0000491)1.89759962
110Lymphopenia (HP:0001888)1.89450694
111Papilledema (HP:0001085)1.89300409
112Pulmonary infiltrates (HP:0002113)1.88932710
113Fatigue (HP:0012378)1.88645378
114Granulocytopenia (HP:0001913)1.88377633
115Stomach cancer (HP:0012126)1.87005169
116Abnormal platelet volume (HP:0011876)1.86586221
117Glomerulopathy (HP:0100820)1.83827776
118Skin ulcer (HP:0200042)1.83594542
119Verrucae (HP:0200043)1.82388183
120Papilloma (HP:0012740)1.82388183
121Neoplasm of the tracheobronchial system (HP:0100552)1.81763469
122Postural instability (HP:0002172)1.81052420
123Encephalitis (HP:0002383)1.80677749
124Nephronophthisis (HP:0000090)1.79779571
125Gingivitis (HP:0000230)1.79050768
126Acne (HP:0001061)1.74179319
127Osteomyelitis (HP:0002754)1.73060067
128Hemiplegia (HP:0002301)1.72396659
129Hypergammaglobulinemia (HP:0010702)1.71476712
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.71368013
131Abnormality of the prostate (HP:0008775)1.70955025
132Nephritis (HP:0000123)1.70793662
133Ulnar claw (HP:0001178)1.70281918
134Hyperkalemia (HP:0002153)1.69807327
135Muscle fiber splitting (HP:0003555)1.69717294
136Keratoconjunctivitis (HP:0001096)1.68700907
137Thyroid-stimulating hormone excess (HP:0002925)1.68130105
138Lip pit (HP:0100267)1.67980264
139Autoimmune thrombocytopenia (HP:0001973)1.67749129
140Combined immunodeficiency (HP:0005387)1.67545896
141Hypoplasia of the thymus (HP:0000778)1.67081924
142Absent frontal sinuses (HP:0002688)1.66812957
143Sudden death (HP:0001699)1.65839171
144Abnormality of the renal medulla (HP:0100957)1.64378513
145Abnormality of the nasal septum (HP:0000419)1.63785920
146Spondylolisthesis (HP:0003302)1.63461135
147Arterial thrombosis (HP:0004420)1.63189758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.64283735
2TXK3.59527048
3TGFBR23.55483688
4MAP2K32.82426016
5MAP4K12.65306936
6GRK72.53195758
7MAPK152.31687122
8IRAK42.19384487
9ITK1.97746137
10TLK11.97130526
11BLK1.96405136
12CLK11.85717760
13CAMK1G1.85408155
14TNIK1.79081008
15NLK1.78953928
16FES1.78688330
17SIK21.78619856
18EPHB11.70407199
19MKNK21.66800537
20ERN11.64849867
21TYK21.63016045
22PKN11.56194253
23MAP3K141.54088602
24TEC1.53940137
25STK101.51374405
26IRAK31.50911614
27IRAK11.50094879
28PIK3CG1.44376997
29CAMK1D1.43476015
30HCK1.36543943
31JAK11.35482692
32MAP3K31.35042380
33CSF1R1.33160745
34IKBKE1.29697551
35CSK1.28819881
36ZAP701.26558634
37TAOK11.25422765
38KSR21.20678840
39MAP3K11.19818022
40LCK1.18660749
41MAP3K21.17984561
42CDK31.16334986
43SGK21.16173351
44PHKG21.12429795
45PHKG11.12429795
46MAPK121.10119531
47PDK21.09764911
48SGK31.05138680
49FGFR31.04869142
50DMPK1.04433363
51RIPK41.04201422
52BTK1.03192211
53ADRBK20.99845566
54YES10.97050770
55SYK0.96828026
56BMPR20.96655939
57EPHA30.96564279
58PRKD20.95598934
59MAP3K60.92550550
60PTK2B0.91772985
61EIF2AK20.90422306
62PRKAA20.88858247
63IRAK20.87848929
64KIT0.86635192
65JAK30.85560502
66PRKCQ0.84622726
67MAP3K110.84411502
68INSRR0.83588183
69MARK20.83455440
70TAOK30.83178402
71MAPK70.81962802
72LYN0.80614170
73IKBKB0.79394491
74OBSCN0.78627795
75TBK10.78433114
76MARK30.77262679
77FRK0.76756366
78MATK0.76044657
79WNK10.75826679
80MAP2K40.75687884
81CDK90.75469612
82FGFR40.73844107
83CDK120.70639149
84MAPK130.69739273
85LRRK20.68064424
86CAMKK20.66707488
87STK390.66400547
88STK110.64936339
89CAMK10.63970206
90RPS6KA50.63640462
91BMPR1B0.63448209
92CAMK40.63342217
93SIK30.62752620
94VRK10.62052511
95BRD40.60577357
96MUSK0.60205727
97PDPK10.60171223
98FGR0.60036295
99SGK4940.59492302
100SGK2230.59492302
101PTK60.58788453
102RET0.57400031
103STK380.57010937
104MAP3K50.56964971
105KSR10.56254986
106HIPK20.55954468
107RAF10.55806705
108CDC42BPA0.55778758
109FYN0.54748529
110PRKD10.54391328
111NTRK20.53559614
112MAP3K70.53042534
113CAMKK10.51938458
114MAP3K100.51508951
115PNCK0.49524141
116FGFR20.49403966
117GRK10.49147833
118TTN0.48789130
119TRIB30.48550899
120PRPF4B0.47167638
121DYRK1B0.47133307
122PRKG10.47108850
123PIK3CA0.46948821
124GRK60.46948722
125MAP3K130.46592180
126STK40.45550790
127TNK20.45538567
128PIM10.44523203
129CHUK0.43154537
130TRPM70.42198012
131MAPK40.41211672
132PDK10.40436525
133MELK0.40157917
134JAK20.40076361
135IGF1R0.39394374
136NUAK10.38676713
137SGK10.37500290
138GRK50.36444866
139ZAK0.36270929

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.99915561
2Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61662713
3Osteoclast differentiation_Homo sapiens_hsa043802.34124585
4B cell receptor signaling pathway_Homo sapiens_hsa046622.30456939
5T cell receptor signaling pathway_Homo sapiens_hsa046602.15599885
6Staphylococcus aureus infection_Homo sapiens_hsa051502.15462723
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.05359949
8Measles_Homo sapiens_hsa051621.81679166
9Other glycan degradation_Homo sapiens_hsa005111.80495353
10Hematopoietic cell lineage_Homo sapiens_hsa046401.80327975
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.80049065
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78447849
13Leishmaniasis_Homo sapiens_hsa051401.70368083
14Non-small cell lung cancer_Homo sapiens_hsa052231.63742746
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.50468688
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40132792
17Legionellosis_Homo sapiens_hsa051341.35613213
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34799386
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34653640
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33225971
21Type I diabetes mellitus_Homo sapiens_hsa049401.32710243
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30256615
23Chemokine signaling pathway_Homo sapiens_hsa040621.29936829
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28063990
25Toxoplasmosis_Homo sapiens_hsa051451.20258593
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19335393
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.17930078
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17340047
29Autoimmune thyroid disease_Homo sapiens_hsa053201.14472782
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.13393996
31Dorso-ventral axis formation_Homo sapiens_hsa043201.11707739
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10470693
33Prolactin signaling pathway_Homo sapiens_hsa049171.09386316
34Pertussis_Homo sapiens_hsa051331.08498106
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08315172
36Graft-versus-host disease_Homo sapiens_hsa053321.07873034
37Acute myeloid leukemia_Homo sapiens_hsa052211.05475031
38Renin secretion_Homo sapiens_hsa049241.05035358
39VEGF signaling pathway_Homo sapiens_hsa043701.03084161
40Viral myocarditis_Homo sapiens_hsa054161.02836995
41Antigen processing and presentation_Homo sapiens_hsa046121.01587377
42Platelet activation_Homo sapiens_hsa046111.00794253
43Endometrial cancer_Homo sapiens_hsa052131.00422589
44Phagosome_Homo sapiens_hsa041451.00042749
45Malaria_Homo sapiens_hsa051440.98687501
46Allograft rejection_Homo sapiens_hsa053300.98000280
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96158240
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95934909
49ABC transporters_Homo sapiens_hsa020100.94706262
50MAPK signaling pathway_Homo sapiens_hsa040100.93817185
51Herpes simplex infection_Homo sapiens_hsa051680.90872120
52Influenza A_Homo sapiens_hsa051640.90594525
53Apoptosis_Homo sapiens_hsa042100.89759774
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89576116
55African trypanosomiasis_Homo sapiens_hsa051430.89215426
56Tuberculosis_Homo sapiens_hsa051520.89010666
57Axon guidance_Homo sapiens_hsa043600.88891441
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88549342
59mTOR signaling pathway_Homo sapiens_hsa041500.85813798
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85741868
61Morphine addiction_Homo sapiens_hsa050320.85178280
62Hepatitis B_Homo sapiens_hsa051610.84567575
63Dilated cardiomyopathy_Homo sapiens_hsa054140.83063460
64Calcium signaling pathway_Homo sapiens_hsa040200.82859858
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82308667
66GnRH signaling pathway_Homo sapiens_hsa049120.81613600
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80741959
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80686384
69Ether lipid metabolism_Homo sapiens_hsa005650.79826619
70Fanconi anemia pathway_Homo sapiens_hsa034600.79251525
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78667986
72Insulin resistance_Homo sapiens_hsa049310.77924638
73Asthma_Homo sapiens_hsa053100.77313545
74TNF signaling pathway_Homo sapiens_hsa046680.76927731
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76826478
76Taste transduction_Homo sapiens_hsa047420.75264386
77Lysine degradation_Homo sapiens_hsa003100.74669805
78Colorectal cancer_Homo sapiens_hsa052100.74378074
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74100154
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73446441
81Notch signaling pathway_Homo sapiens_hsa043300.72970224
82Pancreatic cancer_Homo sapiens_hsa052120.72538469
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.71902204
84cAMP signaling pathway_Homo sapiens_hsa040240.71802782
85ErbB signaling pathway_Homo sapiens_hsa040120.71017686
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68491417
87Renal cell carcinoma_Homo sapiens_hsa052110.68271319
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68191643
89Viral carcinogenesis_Homo sapiens_hsa052030.65979879
90HIF-1 signaling pathway_Homo sapiens_hsa040660.65649930
91Salmonella infection_Homo sapiens_hsa051320.65565435
92Ras signaling pathway_Homo sapiens_hsa040140.64959409
93Shigellosis_Homo sapiens_hsa051310.64930683
94Long-term potentiation_Homo sapiens_hsa047200.64257803
95Glioma_Homo sapiens_hsa052140.63178897
96Oxytocin signaling pathway_Homo sapiens_hsa049210.62677603
97Choline metabolism in cancer_Homo sapiens_hsa052310.62518230
98Inositol phosphate metabolism_Homo sapiens_hsa005620.62379485
99* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61840013
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60617415
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.59866718
102Salivary secretion_Homo sapiens_hsa049700.58969583
103Epstein-Barr virus infection_Homo sapiens_hsa051690.58801906
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.58780392
105Chronic myeloid leukemia_Homo sapiens_hsa052200.58672418
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58539907
107Glutamatergic synapse_Homo sapiens_hsa047240.58407955
108Non-homologous end-joining_Homo sapiens_hsa034500.58348515
109Phototransduction_Homo sapiens_hsa047440.58274450
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58000748
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57879580
112Rap1 signaling pathway_Homo sapiens_hsa040150.57749069
113Sphingolipid metabolism_Homo sapiens_hsa006000.57614678
114Type II diabetes mellitus_Homo sapiens_hsa049300.56817025
115HTLV-I infection_Homo sapiens_hsa051660.55837945
116Prostate cancer_Homo sapiens_hsa052150.54895890
117Hepatitis C_Homo sapiens_hsa051600.54804956
118Serotonergic synapse_Homo sapiens_hsa047260.54789480
119Amoebiasis_Homo sapiens_hsa051460.54107652
120Estrogen signaling pathway_Homo sapiens_hsa049150.53976161
121FoxO signaling pathway_Homo sapiens_hsa040680.53526778
122Rheumatoid arthritis_Homo sapiens_hsa053230.53324327
123Long-term depression_Homo sapiens_hsa047300.53191592
124Endocytosis_Homo sapiens_hsa041440.53002798
125Insulin signaling pathway_Homo sapiens_hsa049100.52713602
126Systemic lupus erythematosus_Homo sapiens_hsa053220.52184341
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51924531
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51258108
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.50754995
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50269630
131Regulation of autophagy_Homo sapiens_hsa041400.48608537
132Pathways in cancer_Homo sapiens_hsa052000.47806157
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47527991
134Nicotine addiction_Homo sapiens_hsa050330.47213504
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46904873
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46610286
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46132159

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