SSH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.83958796
2positive regulation of Cdc42 GTPase activity (GO:0043089)4.71802816
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54631209
4regulation of water loss via skin (GO:0033561)4.27153042
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.21926039
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.21926039
7activation of Rac GTPase activity (GO:0032863)3.91353151
8epithelial cell-cell adhesion (GO:0090136)3.80583006
9maternal placenta development (GO:0001893)3.80094236
10bundle of His cell to Purkinje myocyte communication (GO:0086069)3.77926592
11cell-substrate junction assembly (GO:0007044)3.74381242
12antigen processing and presentation of endogenous antigen (GO:0019883)3.71832936
13antigen processing and presentation via MHC class Ib (GO:0002475)3.71605213
14semaphorin-plexin signaling pathway (GO:0071526)3.66442866
15COPI coating of Golgi vesicle (GO:0048205)3.64486118
16Golgi transport vesicle coating (GO:0048200)3.64486118
17establishment of skin barrier (GO:0061436)3.63692967
18positive regulation by symbiont of host defense response (GO:0052509)3.62291178
19modulation by symbiont of host defense response (GO:0052031)3.62291178
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.62291178
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.62291178
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.62291178
23modulation by symbiont of host immune response (GO:0052553)3.62291178
24negative regulation of cell size (GO:0045792)3.61359790
25macrophage activation involved in immune response (GO:0002281)3.48782347
26mannose metabolic process (GO:0006013)3.48336723
27positive regulation of gamma-delta T cell activation (GO:0046645)3.48143649
28positive regulation of B cell differentiation (GO:0045579)3.46161383
29cell-substrate adherens junction assembly (GO:0007045)3.45874944
30focal adhesion assembly (GO:0048041)3.45874944
31regulation of interferon-beta biosynthetic process (GO:0045357)3.43541315
32multicellular organismal water homeostasis (GO:0050891)3.40327489
33branching involved in mammary gland duct morphogenesis (GO:0060444)3.40012431
34peptidyl-tyrosine autophosphorylation (GO:0038083)3.39911035
35atrioventricular valve morphogenesis (GO:0003181)3.39834471
36adherens junction assembly (GO:0034333)3.31984307
37hemidesmosome assembly (GO:0031581)3.29493703
38negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.24350176
39apoptotic process involved in morphogenesis (GO:0060561)3.23032831
40regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.22323637
41apoptotic cell clearance (GO:0043277)3.19596164
42negative regulation of erythrocyte differentiation (GO:0045647)3.16549464
43ear development (GO:0043583)3.13862625
44planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10773584
45endothelial cell chemotaxis (GO:0035767)3.10413163
46glucose catabolic process (GO:0006007)3.01677713
47positive regulation of keratinocyte differentiation (GO:0045618)2.99546380
48cell-cell junction maintenance (GO:0045217)2.94849565
49proline biosynthetic process (GO:0006561)2.93717840
50regulation of cholesterol biosynthetic process (GO:0045540)2.89118046
51regulation of Cdc42 GTPase activity (GO:0043088)2.85343143
52regulation of extracellular matrix disassembly (GO:0010715)2.84657298
53neutrophil activation involved in immune response (GO:0002283)2.82680377
54amyloid precursor protein catabolic process (GO:0042987)2.82015637
55pentose-phosphate shunt (GO:0006098)2.81477365
56citrulline biosynthetic process (GO:0019240)2.78452494
57regulation of fatty acid beta-oxidation (GO:0031998)2.77967957
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76730437
59dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76440193
60barbed-end actin filament capping (GO:0051016)2.76325669
61mammary gland epithelial cell differentiation (GO:0060644)2.76058687
62regulation of gamma-delta T cell activation (GO:0046643)2.75986569
63positive regulation of histone deacetylation (GO:0031065)2.75563261
64positive regulation of epidermal cell differentiation (GO:0045606)2.75388894
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75011037
66regulation of gamma-delta T cell differentiation (GO:0045586)2.73690764
67negative regulation of fatty acid transport (GO:2000192)2.72843860
68negative regulation of viral release from host cell (GO:1902187)2.72153367
69toxin transport (GO:1901998)2.71581657
70water homeostasis (GO:0030104)2.70923908
71response to interferon-alpha (GO:0035455)2.70214135
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69875817
73response to host immune response (GO:0052572)2.69875817
74positive regulation of receptor recycling (GO:0001921)2.69259549
75protein retention in ER lumen (GO:0006621)2.68400998
76basement membrane organization (GO:0071711)2.68081513
77regulation of mammary gland epithelial cell proliferation (GO:0033599)2.66505899
78immunoglobulin mediated immune response (GO:0016064)2.66178616
79establishment of apical/basal cell polarity (GO:0035089)2.65479991
80glucose 6-phosphate metabolic process (GO:0051156)2.63453954
81response to water (GO:0009415)2.62968274
82virion attachment to host cell (GO:0019062)2.62872033
83adhesion of symbiont to host cell (GO:0044650)2.62872033
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.62487251
85positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.61865893
86regulation of apoptotic process involved in morphogenesis (GO:1902337)2.61275122
87regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58274725
88response to host (GO:0075136)2.57777726
89response to host defenses (GO:0052200)2.57777726
90response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.57777726
91regulation of viral release from host cell (GO:1902186)2.56622819
92myeloid cell activation involved in immune response (GO:0002275)2.55896651
93positive regulation of cellular amide metabolic process (GO:0034250)2.54995921
94amyloid precursor protein metabolic process (GO:0042982)2.54956362
95positive regulation of natural killer cell differentiation (GO:0032825)2.54786507
96surfactant homeostasis (GO:0043129)2.54619342
97embryonic process involved in female pregnancy (GO:0060136)2.53786931
98Rho protein signal transduction (GO:0007266)2.53585932
99positive regulation of p38MAPK cascade (GO:1900745)2.52988609
100retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.51571078
101I-kappaB phosphorylation (GO:0007252)2.49176742
102regulation of endothelial cell chemotaxis (GO:2001026)2.48429903
103citrulline metabolic process (GO:0000052)2.48424988
104positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48384611
105hepatocyte apoptotic process (GO:0097284)2.48302646
106interferon-gamma secretion (GO:0072643)2.47935684
107intestinal epithelial cell development (GO:0060576)2.47615176
108positive regulation of interferon-alpha production (GO:0032727)2.47028072
109GDP-mannose metabolic process (GO:0019673)2.46841032
110regulation of glucose import in response to insulin stimulus (GO:2001273)2.45978664
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45689333
112positive regulation of epidermis development (GO:0045684)2.45507645
113insulin-like growth factor receptor signaling pathway (GO:0048009)2.44051336
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44050154
115regulation of early endosome to late endosome transport (GO:2000641)2.43810021
116epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42447578
117cytokine production involved in immune response (GO:0002367)2.41985684
118adhesion of symbiont to host (GO:0044406)2.41439362
119pinocytosis (GO:0006907)2.41380613
120cell adhesion mediated by integrin (GO:0033627)2.41062201
121cell differentiation involved in embryonic placenta development (GO:0060706)2.39488311
122stress fiber assembly (GO:0043149)2.39402454
123response to type I interferon (GO:0034340)2.38469012
124actin filament bundle assembly (GO:0051017)2.38463628
125actin filament bundle organization (GO:0061572)2.38463628
126activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37870574
127NADPH regeneration (GO:0006740)2.37679788
128skin morphogenesis (GO:0043589)2.36664436
129embryonic eye morphogenesis (GO:0048048)2.35859027
130positive regulation of phagocytosis (GO:0050766)2.35389068
131cellular response to type I interferon (GO:0071357)2.35023305
132type I interferon signaling pathway (GO:0060337)2.35023305
133phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.34226277
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32373971
135regulation of interleukin-12 biosynthetic process (GO:0045075)2.31455462
136myelin maintenance (GO:0043217)2.31339125
137branching involved in salivary gland morphogenesis (GO:0060445)2.31183144
138regulation of interferon-alpha production (GO:0032647)2.31179495
139endosome organization (GO:0007032)2.30620419
140positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.30475373
141growth hormone receptor signaling pathway (GO:0060396)2.30076838
142response to food (GO:0032094)2.29050443
143regulation of ruffle assembly (GO:1900027)2.28684050
144regulation of ARF protein signal transduction (GO:0032012)2.28535008
145regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.28035450
146face development (GO:0060324)2.27900684
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.25562502
148negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24337707
149cytoskeletal anchoring at plasma membrane (GO:0007016)2.23859042
150regulation of cellular amide metabolic process (GO:0034248)2.23396111
151regulation of natural killer cell differentiation (GO:0032823)2.22831663
152positive regulation of nuclease activity (GO:0032075)2.22786271
153phagocytosis (GO:0006909)2.20917644
154interferon-gamma-mediated signaling pathway (GO:0060333)2.19992603
155regulation of B cell differentiation (GO:0045577)2.19142562
156response to peptidoglycan (GO:0032494)2.18521580
157macroautophagy (GO:0016236)2.15457094
158regulation of membrane protein ectodomain proteolysis (GO:0051043)2.15310127
159heparin biosynthetic process (GO:0030210)2.15206252
160heparin metabolic process (GO:0030202)2.15206252
161endoplasmic reticulum unfolded protein response (GO:0030968)2.14918503
162regulation of phagocytosis (GO:0050764)2.13495664
163neutrophil mediated immunity (GO:0002446)2.13051257
164receptor catabolic process (GO:0032801)2.12985550
165regulation of regulated secretory pathway (GO:1903305)2.12737201
166response to protozoan (GO:0001562)2.11712849
167production of molecular mediator of immune response (GO:0002440)2.09257727
168sodium ion export (GO:0071436)2.08963368
169NIK/NF-kappaB signaling (GO:0038061)2.07944512
170positive regulation of natural killer cell activation (GO:0032816)2.06552962
171positive regulation of regulated secretory pathway (GO:1903307)2.05754319
172response to muramyl dipeptide (GO:0032495)2.04687245
173lipopolysaccharide-mediated signaling pathway (GO:0031663)2.04594350
174regulation of cholesterol homeostasis (GO:2000188)2.04592729
175negative regulation of stress fiber assembly (GO:0051497)2.04542934
176regulation of cholesterol storage (GO:0010885)2.04190421
177peptide catabolic process (GO:0043171)2.03928718
178maintenance of gastrointestinal epithelium (GO:0030277)2.03877993
179cellular response to unfolded protein (GO:0034620)2.03770828
180macrophage activation (GO:0042116)2.02574430
181granulocyte activation (GO:0036230)2.01739385
182detection of other organism (GO:0098543)2.00913332
183protein localization to endosome (GO:0036010)2.00884056
184defense response to protozoan (GO:0042832)2.00049403
185phosphatidylglycerol biosynthetic process (GO:0006655)1.99030231
186thrombin receptor signaling pathway (GO:0070493)1.99022677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.49649067
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.37019951
3ZNF263_19887448_ChIP-Seq_K562_Human2.77723167
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.71169513
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49434004
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46547079
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.44533870
8GATA1_22025678_ChIP-Seq_K562_Human2.42288532
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.39207698
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37295937
11SCL_19346495_ChIP-Seq_HPC-7_Human2.33922596
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.25740436
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20562285
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17694089
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.12037800
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10295053
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.03357472
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00794018
19ESR1_21235772_ChIP-Seq_MCF-7_Human1.99801401
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.99222628
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.94314200
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90863100
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90790713
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86754926
25LXR_22292898_ChIP-Seq_THP-1_Human1.86473790
26* SPI1_23127762_ChIP-Seq_K562_Human1.83488207
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.81848640
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81569405
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81068455
30TCF7_22412390_ChIP-Seq_EML_Mouse1.79704571
31* VDR_21846776_ChIP-Seq_THP-1_Human1.76718314
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73218706
33* VDR_24763502_ChIP-Seq_THP-1_Human1.72368523
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69767519
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69284519
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69255341
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65133784
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.65125086
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.65122782
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.64363481
41P68_20966046_ChIP-Seq_HELA_Human1.58694119
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57984110
43PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57050950
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56930123
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56301003
46SMC4_20622854_ChIP-Seq_HELA_Human1.52688979
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.51883464
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50314623
49ATF3_27146783_Chip-Seq_COLON_Human1.49431853
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48429466
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.47314794
52RUNX_20019798_ChIP-Seq_JUKART_Human1.47056723
53MYC_22102868_ChIP-Seq_BL_Human1.45674063
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45215797
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.44601876
56KDM2B_26808549_Chip-Seq_DND41_Human1.44339747
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43540386
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43088997
59CREB1_26743006_Chip-Seq_LNCaP_Human1.43040688
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.42958088
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41194110
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40395613
63RACK7_27058665_Chip-Seq_MCF-7_Human1.40128785
64GATA1_19941826_ChIP-Seq_K562_Human1.40040002
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.38902054
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38751944
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37997399
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37452657
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37428835
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36696047
71MAF_26560356_Chip-Seq_TH1_Human1.34966964
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32639484
73* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32005621
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.31833997
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31789540
76GATA2_19941826_ChIP-Seq_K562_Human1.31638375
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31333012
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27414047
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27212368
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27031535
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26880359
82CLOCK_20551151_ChIP-Seq_293T_Human1.26163887
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26024376
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24942000
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23425106
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22997459
87* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22386712
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22324040
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22052192
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.21968035
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20445751
92* SOX2_20726797_ChIP-Seq_SW620_Human1.19678150
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19622434
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19554825
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.18187668
96UTX_26944678_Chip-Seq_JUKART_Human1.16829181
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16670882
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16109807
99* TP63_22573176_ChIP-Seq_HFKS_Human1.16097806
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15786454
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15207469
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15157164
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14875567
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14820551
105DROSHA_22980978_ChIP-Seq_HELA_Human1.14399030
106MYB_26560356_Chip-Seq_TH2_Human1.14358655
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14066971
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13725391
109BCOR_27268052_Chip-Seq_Bcells_Human1.13333925
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.12910633
111ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12165612
112KLF5_25053715_ChIP-Seq_YYC3_Human1.10931410
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.10709198
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10154819
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10022687
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08488824
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08375594
118KDM2B_26808549_Chip-Seq_K562_Human1.06678965
119TRIM28_21343339_ChIP-Seq_HEK293_Human1.06649481
120RUNX1_27514584_Chip-Seq_MCF-7_Human1.05536379
121VDR_24787735_ChIP-Seq_THP-1_Human1.04802859
122TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04556332
123CTCF_27219007_Chip-Seq_Bcells_Human1.04320601
124* SPI1_23547873_ChIP-Seq_NB4_Human1.04152259
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03822356
126TP53_22127205_ChIP-Seq_IMR90_Human1.03785744
127NCOR1_26117541_ChIP-Seq_K562_Human1.03750641
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02924273
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02924273
130STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02610583
131KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01626676
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01112853
133* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01057936
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00877004
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00765456
136GATA4_25053715_ChIP-Seq_YYC3_Human1.00011539
137PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00007428
138PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99718091
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99674405
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99014746
141GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98978002
142RARB_24833708_ChIP-Seq_LIVER_Mouse0.98303203
143MAF_26560356_Chip-Seq_TH2_Human0.97623578
144FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97320484
145BCL6_27268052_Chip-Seq_Bcells_Human0.97172675
146TET1_21490601_ChIP-Seq_MESCs_Mouse0.96829586
147MYB_26560356_Chip-Seq_TH1_Human0.96775390
148FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96570991
149UBF1/2_26484160_Chip-Seq_HMECs_Human0.96341388
150FOXA2_19822575_ChIP-Seq_HepG2_Human0.96284618
151EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95607949
152GATA6_25053715_ChIP-Seq_YYC3_Human0.95503260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.85352203
2MP0005058_abnormal_lysosome_morphology3.23588282
3MP0003172_abnormal_lysosome_physiology3.13799496
4MP0003300_gastrointestinal_ulcer2.94473840
5MP0003183_abnormal_peptide_metabolism2.69920796
6MP0005501_abnormal_skin_physiology2.52121365
7MP0005076_abnormal_cell_differentiation2.50301045
8MP0000566_synostosis2.43768975
9MP0000579_abnormal_nail_morphology2.38747300
10MP0005464_abnormal_platelet_physiology2.34410143
11MP0003436_decreased_susceptibility_to2.30742555
12MP0001835_abnormal_antigen_presentation2.27962069
13MP0000569_abnormal_digit_pigmentation2.27899595
14MP0002098_abnormal_vibrissa_morphology2.26247557
15MP0003191_abnormal_cellular_cholesterol2.25084784
16MP0005451_abnormal_body_composition2.23959823
17MP0005409_darkened_coat_color2.17757017
18MP0003303_peritoneal_inflammation2.12891924
19MP0004381_abnormal_hair_follicle2.07709575
20MP0002254_reproductive_system_inflammat2.06025124
21MP0004947_skin_inflammation2.05867773
22MP0008260_abnormal_autophagy2.00317879
23MP0003075_altered_response_to1.98223838
24MP0009840_abnormal_foam_cell1.93894746
25MP0002419_abnormal_innate_immunity1.89418096
26MP0003705_abnormal_hypodermis_morpholog1.88160855
27MP0000678_abnormal_parathyroid_gland1.87488087
28MP0000685_abnormal_immune_system1.81103467
29MP0000467_abnormal_esophagus_morphology1.79677300
30MP0000604_amyloidosis1.78747200
31MP0001216_abnormal_epidermal_layer1.74579713
32MP0004185_abnormal_adipocyte_glucose1.74009999
33MP0005025_abnormal_response_to1.70157951
34MP0001790_abnormal_immune_system1.69433998
35MP0005387_immune_system_phenotype1.69433998
36MP0001666_abnormal_nutrient_absorption1.68893991
37MP0009785_altered_susceptibility_to1.65979503
38MP0005083_abnormal_biliary_tract1.65441625
39MP0003866_abnormal_defecation1.65170945
40MP0002877_abnormal_melanocyte_morpholog1.65097218
41MP0002166_altered_tumor_susceptibility1.57668280
42MP0002909_abnormal_adrenal_gland1.57343715
43MP0005310_abnormal_salivary_gland1.57219183
44MP0001873_stomach_inflammation1.57088482
45MP0010155_abnormal_intestine_physiology1.56166211
46MP0005000_abnormal_immune_tolerance1.54608381
47MP0009278_abnormal_bone_marrow1.54065979
48MP0004510_myositis1.50749674
49MP0004782_abnormal_surfactant_physiolog1.50434679
50MP0003566_abnormal_cell_adhesion1.49416354
51MP0001533_abnormal_skeleton_physiology1.48676312
52MP0002452_abnormal_antigen_presenting1.46622840
53MP0002249_abnormal_larynx_morphology1.45938947
54MP0004858_abnormal_nervous_system1.43640787
55MP0000383_abnormal_hair_follicle1.42557801
56MP0000465_gastrointestinal_hemorrhage1.41553726
57MP0000858_altered_metastatic_potential1.39866319
58MP0000377_abnormal_hair_follicle1.37834295
59MP0006082_CNS_inflammation1.37046470
60MP0010771_integument_phenotype1.35044247
61MP0005166_decreased_susceptibility_to1.34891175
62MP0001545_abnormal_hematopoietic_system1.34550888
63MP0005397_hematopoietic_system_phenotyp1.34550888
64MP0002148_abnormal_hypersensitivity_rea1.33530125
65MP0001800_abnormal_humoral_immune1.32995714
66MP0009780_abnormal_chondrocyte_physiolo1.32793503
67MP0002723_abnormal_immune_serum1.32690156
68MP0009384_cardiac_valve_regurgitation1.31277897
69MP0000537_abnormal_urethra_morphology1.31188581
70MP0001845_abnormal_inflammatory_respons1.30426443
71MP0005666_abnormal_adipose_tissue1.29804463
72MP0006054_spinal_hemorrhage1.28695324
73MP0005174_abnormal_tail_pigmentation1.27737115
74MP0004264_abnormal_extraembryonic_tissu1.26732150
75MP0005167_abnormal_blood-brain_barrier1.26104884
76MP0003724_increased_susceptibility_to1.25711181
77MP0000762_abnormal_tongue_morphology1.24580303
78MP0009931_abnormal_skin_appearance1.23125601
79MP0002420_abnormal_adaptive_immunity1.23117475
80MP0001819_abnormal_immune_cell1.22667372
81MP0005375_adipose_tissue_phenotype1.19879864
82MP0008438_abnormal_cutaneous_collagen1.19105378
83MP0001849_ear_inflammation1.18973753
84MP0002006_tumorigenesis1.16546756
85MP0001958_emphysema1.15128308
86MP0002796_impaired_skin_barrier1.15086357
87MP0005671_abnormal_response_to1.14774664
88MP0000003_abnormal_adipose_tissue1.14765331
89MP0008469_abnormal_protein_level1.14480812
90MP0000627_abnormal_mammary_gland1.14055688
91MP0003453_abnormal_keratinocyte_physiol1.13884894
92MP0008961_abnormal_basal_metabolism1.13860968
93MP0010678_abnormal_skin_adnexa1.12166397
94MP0003045_fibrosis1.09806411
95MP0003690_abnormal_glial_cell1.08706656
96MP0005275_abnormal_skin_tensile1.08033585
97MP0004272_abnormal_basement_membrane1.07533061
98MP0002998_abnormal_bone_remodeling1.06731175
99MP0000343_altered_response_to1.05230178
100MP0004130_abnormal_muscle_cell1.04795064
101MP0010030_abnormal_orbit_morphology1.04486754
102MP0005377_hearing/vestibular/ear_phenot1.03290750
103MP0003878_abnormal_ear_physiology1.03290750
104MP0009643_abnormal_urine_homeostasis1.02746484
105MP0010329_abnormal_lipoprotein_level1.01288701
106MP0003329_amyloid_beta_deposits0.99367283
107MP0001348_abnormal_lacrimal_gland0.98719933
108MP0001881_abnormal_mammary_gland0.96754493
109MP0010386_abnormal_urinary_bladder0.96395470
110MP0005257_abnormal_intraocular_pressure0.96354214
111MP0002060_abnormal_skin_morphology0.95568947
112MP0003252_abnormal_bile_duct0.94631948
113MP0003656_abnormal_erythrocyte_physiolo0.94225937
114MP0009764_decreased_sensitivity_to0.94046731
115MP0001664_abnormal_digestion0.91735031
116MP0002089_abnormal_postnatal_growth/wei0.90654516
117MP0005365_abnormal_bile_salt0.90484307
118MP0001765_abnormal_ion_homeostasis0.90465487
119MP0000716_abnormal_immune_system0.87382728
120MP0008004_abnormal_stomach_pH0.86940256
121MP0001663_abnormal_digestive_system0.86494037
122MP0005360_urolithiasis0.85484396
123MP0003091_abnormal_cell_migration0.83382895
124MP0002136_abnormal_kidney_physiology0.82685511
125MP0000462_abnormal_digestive_system0.82282624
126MP0002405_respiratory_system_inflammati0.82234256
127MP0005023_abnormal_wound_healing0.81889477
128MP0002118_abnormal_lipid_homeostasis0.80973579
129MP0000609_abnormal_liver_physiology0.80901892
130MP0002896_abnormal_bone_mineralization0.80895327
131MP0005220_abnormal_exocrine_pancreas0.79780354
132MP0003123_paternal_imprinting0.78374385
133MP0001756_abnormal_urination0.78268009
134MP0002398_abnormal_bone_marrow0.77973870
135MP0000490_abnormal_crypts_of0.77790393
136MP0002139_abnormal_hepatobiliary_system0.77786766
137MP0010352_gastrointestinal_tract_polyps0.76562876
138MP0004859_abnormal_synaptic_plasticity0.76265805
139MP0003638_abnormal_response/metabolism_0.75825756
140MP0000470_abnormal_stomach_morphology0.75232474
141MP0004808_abnormal_hematopoietic_stem0.75087779
142MP0003879_abnormal_hair_cell0.74711259
143MP0004233_abnormal_muscle_weight0.73960990
144MP0000477_abnormal_intestine_morphology0.73474907
145MP0000681_abnormal_thyroid_gland0.73306881
146MP0003941_abnormal_skin_development0.73152878
147MP0000689_abnormal_spleen_morphology0.73030416
148MP0005670_abnormal_white_adipose0.71436459
149MP0001243_abnormal_dermal_layer0.71095014
150MP0005248_abnormal_Harderian_gland0.70034749
151MP0000534_abnormal_ureter_morphology0.68953072
152MP0005390_skeleton_phenotype0.68148766
153MP0000367_abnormal_coat/_hair0.66111610
154MP0002132_abnormal_respiratory_system0.65833392
155MP0000767_abnormal_smooth_muscle0.65536537
156MP0006138_congestive_heart_failure0.64807834
157MP0003279_aneurysm0.64064129
158MP0003115_abnormal_respiratory_system0.62350269
159MP0004019_abnormal_vitamin_homeostasis0.61067811

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)3.94163732
2Dysostosis multiplex (HP:0000943)3.80559818
3Vacuolated lymphocytes (HP:0001922)3.66381647
4Recurrent bacterial skin infections (HP:0005406)3.60815746
5Mucopolysacchariduria (HP:0008155)3.43926048
6Urinary glycosaminoglycan excretion (HP:0003541)3.43926048
7Recurrent abscess formation (HP:0002722)3.42400688
8Distal lower limb muscle weakness (HP:0009053)3.39055267
9Abnormality of mucopolysaccharide metabolism (HP:0011020)3.33606782
10Abnormality of polysaccharide metabolism (HP:0011012)3.33606782
11Abnormality of glycosaminoglycan metabolism (HP:0004371)3.33606782
12Chronic otitis media (HP:0000389)3.31881896
13Eczematoid dermatitis (HP:0000976)3.23202423
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.16415327
15Interstitial pulmonary disease (HP:0006530)3.12106533
16Loss of speech (HP:0002371)3.05771783
17J-shaped sella turcica (HP:0002680)3.01483700
18Abnormality of macrophages (HP:0004311)3.00149011
19Periodontitis (HP:0000704)2.85302022
20Hematochezia (HP:0002573)2.83733435
21Abnormal hair laboratory examination (HP:0003328)2.79210824
22Milia (HP:0001056)2.77642659
23Fragile skin (HP:0001030)2.74175109
24Distal lower limb amyotrophy (HP:0008944)2.71915855
25Hyperacusis (HP:0010780)2.68031986
26Abnormality of liposaccharide metabolism (HP:0010968)2.66379453
27Abnormality of glycosphingolipid metabolism (HP:0004343)2.66379453
28Abnormality of glycolipid metabolism (HP:0010969)2.66379453
29Abnormality of nail color (HP:0100643)2.65019097
30Increased IgE level (HP:0003212)2.62185278
31Abnormality of the distal phalanges of the toes (HP:0010182)2.56604906
32Autoimmune thrombocytopenia (HP:0001973)2.56589062
33Hemorrhage of the eye (HP:0011885)2.55130292
34Protrusio acetabuli (HP:0003179)2.53304313
35Obstructive sleep apnea (HP:0002870)2.51899788
36Recurrent gram-negative bacterial infections (HP:0005420)2.49135921
37Fragile nails (HP:0001808)2.47792093
38Cellulitis (HP:0100658)2.42136223
39Prolonged bleeding time (HP:0003010)2.40019942
40Alopecia of scalp (HP:0002293)2.39031847
41Short nail (HP:0001799)2.37750558
42Advanced eruption of teeth (HP:0006288)2.36649802
43Increased connective tissue (HP:0009025)2.36041646
44Septate vagina (HP:0001153)2.35859614
45Myositis (HP:0100614)2.35658367
46Atrophic scars (HP:0001075)2.34201154
47Cerebral aneurysm (HP:0004944)2.31016883
48Stridor (HP:0010307)2.29104723
49Amelogenesis imperfecta (HP:0000705)2.28752245
50Vertebral compression fractures (HP:0002953)2.28396358
51Gingival bleeding (HP:0000225)2.27086292
52Nail dystrophy (HP:0008404)2.26936000
53Axonal loss (HP:0003447)2.26207631
54Elevated erythrocyte sedimentation rate (HP:0003565)2.25531639
55Thoracic kyphosis (HP:0002942)2.25270865
56Pustule (HP:0200039)2.25203814
57Onycholysis (HP:0001806)2.24484726
58Thrombocytosis (HP:0001894)2.24295763
59Cervical subluxation (HP:0003308)2.22315585
60Asymmetry of the thorax (HP:0001555)2.21771701
61Mildly elevated creatine phosphokinase (HP:0008180)2.21203164
62Premature rupture of membranes (HP:0001788)2.19986373
63Abnormal platelet function (HP:0011869)2.19840261
64Impaired platelet aggregation (HP:0003540)2.19840261
65Acanthosis nigricans (HP:0000956)2.18955984
66Easy fatigability (HP:0003388)2.18532020
67Lip pit (HP:0100267)2.13579053
68Petechiae (HP:0000967)2.11846528
69Recurrent skin infections (HP:0001581)2.10543212
70Systemic lupus erythematosus (HP:0002725)2.10521129
71Epistaxis (HP:0000421)2.09886019
72Deep venous thrombosis (HP:0002625)2.08216513
73Right ventricular cardiomyopathy (HP:0011663)2.08185780
74Pterygium (HP:0001059)2.08155786
75Plantar hyperkeratosis (HP:0007556)2.06932629
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06356700
77Recurrent fungal infections (HP:0002841)2.06114237
78Recurrent viral infections (HP:0004429)2.05506079
79Gastrointestinal inflammation (HP:0004386)2.04695565
80Abnormality of the thoracic spine (HP:0100711)2.03463804
81Inflammation of the large intestine (HP:0002037)2.03211945
82Bulbar palsy (HP:0001283)2.01453844
83Lymphangioma (HP:0100764)2.00926411
84Long toe (HP:0010511)2.00284532
85Colitis (HP:0002583)1.98082848
86Menorrhagia (HP:0000132)1.97886918
87Germ cell neoplasia (HP:0100728)1.97519285
88Abdominal distention (HP:0003270)1.96952747
89Curly hair (HP:0002212)1.96882276
90Hyperparathyroidism (HP:0000843)1.96535485
91Micronodular cirrhosis (HP:0001413)1.96492985
92Radial bowing (HP:0002986)1.96320280
93Spinal cord compression (HP:0002176)1.96226405
94Fatigue (HP:0012378)1.96116704
95Hypoplasia of dental enamel (HP:0006297)1.95964890
96Growth hormone excess (HP:0000845)1.95088872
97Ulnar bowing (HP:0003031)1.95007879
98Gingivitis (HP:0000230)1.94702179
99Achilles tendon contracture (HP:0001771)1.92497898
100Thin bony cortex (HP:0002753)1.92464819
101Abnormal blistering of the skin (HP:0008066)1.92087812
102Aortic aneurysm (HP:0004942)1.91778450
103Spondylolisthesis (HP:0003302)1.89683642
104Arterial thrombosis (HP:0004420)1.89592087
105Trismus (HP:0000211)1.89227951
106Selective tooth agenesis (HP:0001592)1.88807900
107Flat acetabular roof (HP:0003180)1.88525053
108Abnormality of the lumbar spine (HP:0100712)1.88306305
109Ridged nail (HP:0001807)1.85541088
110Abnormality of the salivary glands (HP:0010286)1.85443354
111Arterial tortuosity (HP:0005116)1.85349899
112Orchitis (HP:0100796)1.84864120
113Polygenic inheritance (HP:0010982)1.84804564
114Supranuclear gaze palsy (HP:0000605)1.83893972
115Amyloidosis (HP:0011034)1.83430351
116Sparse lateral eyebrow (HP:0005338)1.82219126
117Disinhibition (HP:0000734)1.82163470
118Pili torti (HP:0003777)1.80117912
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.77412043
120Hypotrichosis (HP:0001006)1.77139678
121Hand muscle atrophy (HP:0009130)1.77027070
122Protuberant abdomen (HP:0001538)1.76808352
123Thick nail (HP:0001805)1.76622556
124Bone pain (HP:0002653)1.76123639
125Abnormality of the Achilles tendon (HP:0005109)1.75447234
126Shallow orbits (HP:0000586)1.75228841
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.74628620
128Osteolytic defects of the hand bones (HP:0009699)1.74628620
129Tetraparesis (HP:0002273)1.74267111
130Ventricular tachycardia (HP:0004756)1.74238397
131Premature loss of primary teeth (HP:0006323)1.74226725
132Abnormality of the intrinsic pathway (HP:0010989)1.74210199
133Malnutrition (HP:0004395)1.74161383
134Palmoplantar hyperkeratosis (HP:0000972)1.73823029
135Natal tooth (HP:0000695)1.73628105
136Abnormality of the nasal mucosa (HP:0000433)1.73362414
137Abnormal platelet volume (HP:0011876)1.73301286
138Congenital glaucoma (HP:0001087)1.73274669
139Osteomyelitis (HP:0002754)1.72868678
140Difficulty climbing stairs (HP:0003551)1.72400742
141Abnormal vertebral ossification (HP:0100569)1.71667263
142Metaphyseal cupping (HP:0003021)1.71066915
143Blue sclerae (HP:0000592)1.70814479
144Upper limb amyotrophy (HP:0009129)1.70138720
145Distal upper limb amyotrophy (HP:0007149)1.70138720
146Focal segmental glomerulosclerosis (HP:0000097)1.70114107
147Deformed sella turcica (HP:0002681)1.69925298
148Myocardial infarction (HP:0001658)1.69462118
149Joint stiffness (HP:0001387)1.69361146
150Increased CSF protein (HP:0002922)1.69244336
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68565788
152Aneurysm (HP:0002617)1.68527423
153Increased mean platelet volume (HP:0011877)1.68077129
154Retinal atrophy (HP:0001105)1.67680910
155Esophageal varix (HP:0002040)1.66756780
156Broad face (HP:0000283)1.66664397
157Striae distensae (HP:0001065)1.66523669
158Glomerulosclerosis (HP:0000096)1.66055740
159Beaking of vertebral bodies (HP:0004568)1.65644814
160Glomerulonephritis (HP:0000099)1.65627078
161Flattened epiphyses (HP:0003071)1.65273104
162Bronchomalacia (HP:0002780)1.65034015
163Frequent falls (HP:0002359)1.64816423
164Mitral regurgitation (HP:0001653)1.64779202
165Broad metatarsal (HP:0001783)1.64769044
166Spontaneous hematomas (HP:0007420)1.63139726
167Vascular tortuosity (HP:0004948)1.62895695
168Facial diplegia (HP:0001349)1.62497036
169Bowed forearm bones (HP:0003956)1.59888316

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.10053010
2TRIB33.33484328
3SMG12.39768992
4EEF2K2.34570493
5RIPK12.27203506
6PTK62.24420732
7SIK12.20801240
8EPHB12.19924809
9PKN22.17071072
10MAP4K12.16992954
11KIT2.06868746
12TYK22.05160481
13RIPK42.03470050
14ICK1.96080942
15TAOK31.91380229
16TBK11.86133084
17TESK11.85397800
18MAP3K131.81690174
19MAP3K21.72368111
20JAK31.65615754
21MET1.63892294
22TGFBR21.63463382
23PRPF4B1.61937672
24FES1.55797513
25JAK11.54109788
26NME21.51628418
27KSR21.50860158
28MATK1.49586367
29MAP2K31.47063690
30FRK1.44152027
31CAMKK21.40247619
32MAP3K91.37844095
33SCYL21.37237564
34BTK1.35537057
35TAOK11.34114769
36IKBKE1.33593571
37PRKD21.32300581
38LRRK21.32240317
39MAPKAPK31.31521463
40DAPK21.28385944
41MAP3K11.27819497
42CAMKK11.27260452
43ZAP701.27012136
44MAP3K141.26505932
45TESK21.19468693
46TTN1.18881033
47FGFR41.13726563
48GRK61.10460647
49CDK121.10453662
50MAP3K31.07167848
51SIK21.06300890
52PAK41.06046183
53FLT31.05320694
54CSF1R1.03814774
55JAK21.02506755
56MAP3K71.02447036
57MAPK151.00348131
58MAP3K60.96311467
59LMTK20.95986407
60MTOR0.91348675
61PTK20.91338362
62CDC42BPA0.91291541
63IRAK30.90738168
64CAMK1D0.89891257
65IRAK40.88103753
66SYK0.87769934
67EPHA20.87644693
68BLK0.87444470
69RET0.87320085
70SIK30.86372043
71CSK0.84790002
72TAOK20.81638925
73IRAK20.80900553
74MUSK0.78382044
75ARAF0.77277276
76TEC0.75626758
77LATS20.74659550
78FER0.74409356
79HIPK20.74280007
80NTRK10.74274594
81CDK190.73516408
82PDPK10.73374305
83HCK0.73067995
84MARK20.71885737
85PDK10.68624719
86TRPM70.67625675
87PRKCH0.66817476
88FGFR30.66470616
89MAP2K20.66136478
90PDGFRB0.65037999
91PRKCI0.65010792
92BMX0.63434501
93ITK0.63389468
94PIK3CG0.63189773
95PRKG20.62508006
96IKBKB0.62460122
97MAP2K60.62182352
98CAMK1G0.61648613
99RPS6KL10.60776222
100RPS6KC10.60776222
101ILK0.60127701
102MAPKAPK50.59639617
103PDGFRA0.59276568
104RPS6KA20.58064481
105DDR20.57799719
106EPHB20.57417785
107DAPK10.57027381
108MST1R0.56705905
109EPHA30.56166130
110LCK0.55856444
111TNK20.55658575
112MAP3K110.55278829
113CHUK0.55063330
114STK380.54803736
115NME10.54148862
116MAP2K10.52445083
117NEK60.51842998
118MAPKAPK20.50779855
119LATS10.49755207
120STK100.48635092
121RPS6KB20.45837151
122CDK70.45460246
123TGFBR10.44193696
124CAMK10.43952571
125PRKD10.43482942
126RPS6KA60.42915187
127FYN0.42380697
128TNIK0.42008939
129SGK30.41811113
130CDK60.40626785
131SRC0.40027497
132LYN0.39724031
133PRKD30.38488999
134IRAK10.31107451
135MAPK110.30993160
136DYRK1B0.30836544
137DMPK0.28759891
138CAMK2G0.28523230
139MAP3K100.26920516
140PIM20.26676682
141MAP3K80.25397948

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysosome_Homo sapiens_hsa041422.20916451
2Other glycan degradation_Homo sapiens_hsa005112.18667197
3Notch signaling pathway_Homo sapiens_hsa043302.16266043
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.06627030
5Caffeine metabolism_Homo sapiens_hsa002322.02963404
6Cyanoamino acid metabolism_Homo sapiens_hsa004601.96422041
7Leishmaniasis_Homo sapiens_hsa051401.83008125
8Osteoclast differentiation_Homo sapiens_hsa043801.74703383
9B cell receptor signaling pathway_Homo sapiens_hsa046621.61461177
10Bladder cancer_Homo sapiens_hsa052191.59443664
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.56775470
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56540348
13Thyroid cancer_Homo sapiens_hsa052161.54768137
14Pentose phosphate pathway_Homo sapiens_hsa000301.42684686
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37505891
16Toxoplasmosis_Homo sapiens_hsa051451.34676898
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34265387
18Insulin signaling pathway_Homo sapiens_hsa049101.33373430
19Pertussis_Homo sapiens_hsa051331.31116555
20Tuberculosis_Homo sapiens_hsa051521.27791381
21Type II diabetes mellitus_Homo sapiens_hsa049301.27744854
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26918544
23Staphylococcus aureus infection_Homo sapiens_hsa051501.23049280
24Platelet activation_Homo sapiens_hsa046111.21525631
25Phenylalanine metabolism_Homo sapiens_hsa003601.16760835
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15998515
27Renal cell carcinoma_Homo sapiens_hsa052111.15329421
28AMPK signaling pathway_Homo sapiens_hsa041521.14404958
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14373228
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12688363
31ErbB signaling pathway_Homo sapiens_hsa040121.12167168
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07954342
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07326777
34Acute myeloid leukemia_Homo sapiens_hsa052211.06825566
35Influenza A_Homo sapiens_hsa051641.06420620
36TNF signaling pathway_Homo sapiens_hsa046681.06081443
37Choline metabolism in cancer_Homo sapiens_hsa052311.04093968
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04025619
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02817977
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.02622286
41Shigellosis_Homo sapiens_hsa051311.02208329
42Amoebiasis_Homo sapiens_hsa051461.01252108
43Pancreatic secretion_Homo sapiens_hsa049721.01153081
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99348384
45Salmonella infection_Homo sapiens_hsa051320.98521528
46Insulin resistance_Homo sapiens_hsa049310.96430183
47Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96102865
48Hepatitis C_Homo sapiens_hsa051600.95951821
49Fatty acid biosynthesis_Homo sapiens_hsa000610.94133333
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.94009997
51Chronic myeloid leukemia_Homo sapiens_hsa052200.92548247
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91469576
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.90927945
54Prolactin signaling pathway_Homo sapiens_hsa049170.89964023
55Tight junction_Homo sapiens_hsa045300.89266871
56Sphingolipid metabolism_Homo sapiens_hsa006000.88276843
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87756743
58Apoptosis_Homo sapiens_hsa042100.87405578
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86800676
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.86375591
61Pancreatic cancer_Homo sapiens_hsa052120.85919442
62Measles_Homo sapiens_hsa051620.85864120
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.85298446
64N-Glycan biosynthesis_Homo sapiens_hsa005100.84023007
65Legionellosis_Homo sapiens_hsa051340.82666679
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82359623
67Sulfur relay system_Homo sapiens_hsa041220.82339624
68Galactose metabolism_Homo sapiens_hsa000520.81133690
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80559789
70Renin-angiotensin system_Homo sapiens_hsa046140.80007342
71Synaptic vesicle cycle_Homo sapiens_hsa047210.79911526
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79853410
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79070891
74Chemokine signaling pathway_Homo sapiens_hsa040620.78771477
75Malaria_Homo sapiens_hsa051440.78227842
76Phagosome_Homo sapiens_hsa041450.78150263
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77905724
78Nitrogen metabolism_Homo sapiens_hsa009100.77576841
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.76999721
80Vibrio cholerae infection_Homo sapiens_hsa051100.76583150
81VEGF signaling pathway_Homo sapiens_hsa043700.76494721
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76200555
83Adherens junction_Homo sapiens_hsa045200.75227217
84Rheumatoid arthritis_Homo sapiens_hsa053230.74586171
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74083269
86Gastric acid secretion_Homo sapiens_hsa049710.73346781
87ABC transporters_Homo sapiens_hsa020100.72686183
88Bile secretion_Homo sapiens_hsa049760.72602872
89Endocytosis_Homo sapiens_hsa041440.70964922
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70346370
91* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70224850
92Protein digestion and absorption_Homo sapiens_hsa049740.70022050
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69156135
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68886229
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.68856797
96Proteoglycans in cancer_Homo sapiens_hsa052050.67909977
97Focal adhesion_Homo sapiens_hsa045100.67605348
98Histidine metabolism_Homo sapiens_hsa003400.66676042
99Prostate cancer_Homo sapiens_hsa052150.66599334
100Fat digestion and absorption_Homo sapiens_hsa049750.65601613
101Thyroid hormone synthesis_Homo sapiens_hsa049180.64994829
102Collecting duct acid secretion_Homo sapiens_hsa049660.64942669
103Antigen processing and presentation_Homo sapiens_hsa046120.64131151
104Hematopoietic cell lineage_Homo sapiens_hsa046400.63883401
105Axon guidance_Homo sapiens_hsa043600.63772206
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62696708
107Hepatitis B_Homo sapiens_hsa051610.62341366
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62266486
109Inositol phosphate metabolism_Homo sapiens_hsa005620.61692941
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60652545
111ECM-receptor interaction_Homo sapiens_hsa045120.60388143
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.60195725
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59979798
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58589903
115Glioma_Homo sapiens_hsa052140.58262634
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57946700
117Non-small cell lung cancer_Homo sapiens_hsa052230.57578276
118mTOR signaling pathway_Homo sapiens_hsa041500.57155894
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55613082
120Fructose and mannose metabolism_Homo sapiens_hsa000510.55301430
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55141676
122Mineral absorption_Homo sapiens_hsa049780.55141543
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54822081
124Endometrial cancer_Homo sapiens_hsa052130.54693679
125Prion diseases_Homo sapiens_hsa050200.54623924
126Small cell lung cancer_Homo sapiens_hsa052220.53605477
127Rap1 signaling pathway_Homo sapiens_hsa040150.53102770
128GnRH signaling pathway_Homo sapiens_hsa049120.51979025
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.51223311
130HIF-1 signaling pathway_Homo sapiens_hsa040660.50831415
131Estrogen signaling pathway_Homo sapiens_hsa049150.50826404
132Glucagon signaling pathway_Homo sapiens_hsa049220.49376789
133Arginine biosynthesis_Homo sapiens_hsa002200.48697931
134PPAR signaling pathway_Homo sapiens_hsa033200.46830117
135Pathways in cancer_Homo sapiens_hsa052000.46586181
136Melanogenesis_Homo sapiens_hsa049160.43428448
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43124454

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