SSMEM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.96673710
2piRNA metabolic process (GO:0034587)9.92901046
3epithelial cilium movement (GO:0003351)9.56414423
4spermatid development (GO:0007286)9.34238367
5male meiosis (GO:0007140)9.04088235
6motile cilium assembly (GO:0044458)9.03200921
7reproduction (GO:0000003)8.87499022
8synaptonemal complex organization (GO:0070193)8.72685075
9synaptonemal complex assembly (GO:0007130)8.51908950
10cilium movement (GO:0003341)8.20216964
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.11533537
12regulation of cilium movement (GO:0003352)7.87286877
13single fertilization (GO:0007338)7.27339171
14sperm capacitation (GO:0048240)6.58684695
15protein targeting to Golgi (GO:0000042)6.58640741
16DNA methylation involved in gamete generation (GO:0043046)6.45097399
17negative regulation of inclusion body assembly (GO:0090084)6.39777755
18fertilization (GO:0009566)6.38306509
19spermatogenesis (GO:0007283)6.36816108
20male gamete generation (GO:0048232)6.34769414
21establishment of protein localization to Golgi (GO:0072600)6.30402035
22retrograde transport, vesicle recycling within Golgi (GO:0000301)6.23668712
23male meiosis I (GO:0007141)6.22302929
24chromosome organization involved in meiosis (GO:0070192)5.91781041
25gamete generation (GO:0007276)5.84020513
26microtubule depolymerization (GO:0007019)5.75743926
27germ cell development (GO:0007281)5.42408890
28organic cation transport (GO:0015695)5.41182627
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.40858613
30meiotic nuclear division (GO:0007126)5.36686294
31response to pheromone (GO:0019236)5.26585240
32regulation of inclusion body assembly (GO:0090083)5.20173251
33ventricular system development (GO:0021591)5.17465630
34histone H3-K9 demethylation (GO:0033169)5.14432348
35seminiferous tubule development (GO:0072520)5.07393428
36meiosis I (GO:0007127)5.06505649
37rRNA methylation (GO:0031167)5.01159569
38calcium ion-dependent exocytosis (GO:0017156)4.89406591
39cell recognition (GO:0008037)4.78269392
40microtubule severing (GO:0051013)4.66320113
41protein localization to Golgi apparatus (GO:0034067)4.61893733
42regulation of microtubule-based movement (GO:0060632)4.61679950
43multicellular organismal reproductive process (GO:0048609)4.56947830
44DNA synthesis involved in DNA repair (GO:0000731)4.40131845
45meiotic cell cycle (GO:0051321)4.35775961
46monoubiquitinated protein deubiquitination (GO:0035520)4.23922227
47RNA destabilization (GO:0050779)4.23347792
48phosphatidylethanolamine biosynthetic process (GO:0006646)4.21457425
49sexual reproduction (GO:0019953)4.18426448
50regulation of histone H3-K9 methylation (GO:0051570)4.17714356
51positive regulation of Rab GTPase activity (GO:0032851)4.13697342
52regulation of Rab GTPase activity (GO:0032313)4.13697342
53chromosome condensation (GO:0030261)4.07946963
54left/right pattern formation (GO:0060972)4.05279302
55protein localization to cilium (GO:0061512)4.04698383
56genitalia morphogenesis (GO:0035112)4.02369323
57rRNA modification (GO:0000154)4.01231994
58DNA packaging (GO:0006323)4.00976650
59spermatid nucleus differentiation (GO:0007289)3.97768537
60female gamete generation (GO:0007292)3.94587195
61glycerol ether metabolic process (GO:0006662)3.93214918
62microtubule nucleation (GO:0007020)3.90162756
63phosphatidylethanolamine metabolic process (GO:0046337)3.89897824
64regulation of female gonad development (GO:2000194)3.88861697
65chaperone-mediated protein complex assembly (GO:0051131)3.84304778
66protein polyglutamylation (GO:0018095)3.78818671
67multicellular organismal development (GO:0007275)3.70797542
68chromatin silencing (GO:0006342)3.64722562
69negative regulation of histone methylation (GO:0031061)3.63951546
70ether metabolic process (GO:0018904)3.62718084
71regulation of DNA methylation (GO:0044030)3.62080685
72meiotic cell cycle process (GO:1903046)3.61108151
73gene silencing by RNA (GO:0031047)3.60755195
74nuclear pore organization (GO:0006999)3.58984563
75intraciliary transport (GO:0042073)3.50493027
76synapsis (GO:0007129)3.49722406
77regulation of acrosome reaction (GO:0060046)3.37789543
78regulation of spindle checkpoint (GO:0090231)3.37183828
79oogenesis (GO:0048477)3.35254713
80sister chromatid cohesion (GO:0007062)3.31116010
81cerebral cortex neuron differentiation (GO:0021895)3.29472937
82regulation of meiosis I (GO:0060631)3.28386109
83axoneme assembly (GO:0035082)3.27458594
84resolution of meiotic recombination intermediates (GO:0000712)3.24776727
85centrosome duplication (GO:0051298)3.21316436
86positive regulation of meiosis (GO:0045836)3.12269944
87mitotic sister chromatid cohesion (GO:0007064)3.09767751
88microtubule-based movement (GO:0007018)3.08530167
89carnitine transport (GO:0015879)3.08211709
90amino-acid betaine transport (GO:0015838)3.08211709
91negative regulation of organelle assembly (GO:1902116)3.06715918
92single strand break repair (GO:0000012)3.06144722
93protein K11-linked deubiquitination (GO:0035871)3.05781562
94interferon-gamma secretion (GO:0072643)3.05314193
95lactate metabolic process (GO:0006089)3.04505722
96sequestering of actin monomers (GO:0042989)3.03446871
97cilium organization (GO:0044782)3.03318832
98carnitine transmembrane transport (GO:1902603)3.03065876
99nuclear pore complex assembly (GO:0051292)3.02546261
100pore complex assembly (GO:0046931)2.99749395
101protein refolding (GO:0042026)2.98230059
102positive regulation of meiotic cell cycle (GO:0051446)2.98073925
103regulation of centriole replication (GO:0046599)2.96511051
104response to acidic pH (GO:0010447)2.95064895
105nucleoside diphosphate phosphorylation (GO:0006165)2.94997490
106cellular response to pH (GO:0071467)2.94757146
107multicellular organismal movement (GO:0050879)2.94195601
108musculoskeletal movement (GO:0050881)2.94195601
109regulation of meiotic cell cycle (GO:0051445)2.93758590
110reciprocal DNA recombination (GO:0035825)2.93262637
111microtubule polymerization or depolymerization (GO:0031109)2.92962691
112polyol catabolic process (GO:0046174)2.90774202
113alditol metabolic process (GO:0019400)2.90765255
114nucleus organization (GO:0006997)2.87841676
115cilium assembly (GO:0042384)2.87479555
116cellular component assembly involved in morphogenesis (GO:0010927)2.85707141
117cilium morphogenesis (GO:0060271)2.85093015
118GTP biosynthetic process (GO:0006183)2.83985321
119glycolytic process (GO:0006096)2.75361528
120gene silencing (GO:0016458)2.70009940
121centriole assembly (GO:0098534)2.63223040
122regulation of protein polyubiquitination (GO:1902914)2.58435734
123centriole replication (GO:0007099)2.54842929
124peptidyl-glutamic acid modification (GO:0018200)2.54691823
125UTP biosynthetic process (GO:0006228)2.52965173
126histone exchange (GO:0043486)2.49258403
127fusion of sperm to egg plasma membrane (GO:0007342)13.1291528
128sperm motility (GO:0030317)12.7248130
129cilium or flagellum-dependent cell motility (GO:0001539)12.2494206
130acrosome assembly (GO:0001675)11.8540579
131sperm-egg recognition (GO:0035036)11.1911688
132acrosome reaction (GO:0007340)10.7484264
133multicellular organism reproduction (GO:0032504)10.7279488
134binding of sperm to zona pellucida (GO:0007339)10.3806259
135cell wall macromolecule metabolic process (GO:0044036)10.3786116
136cell wall macromolecule catabolic process (GO:0016998)10.3786116
137axonemal dynein complex assembly (GO:0070286)10.3265054
138cell-cell recognition (GO:0009988)10.0066547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.95421210
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.82391361
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60077127
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.43689853
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.24292037
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.57997849
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55621347
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.37571893
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36757942
10FUS_26573619_Chip-Seq_HEK293_Human2.31810673
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22794988
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22161441
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16296918
14ZNF274_21170338_ChIP-Seq_K562_Hela2.15178518
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06163892
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05793276
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.03070692
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8869498
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.99406996
20VDR_22108803_ChIP-Seq_LS180_Human1.96716613
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.94183023
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83725585
23NANOG_20526341_ChIP-Seq_ESCs_Human1.78458428
24ER_23166858_ChIP-Seq_MCF-7_Human1.77559843
25KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76913565
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.70609759
27SMAD4_21741376_ChIP-Seq_EPCs_Human1.68503341
28STAT1_17558387_ChIP-Seq_HELA_Human1.68284256
29ERA_21632823_ChIP-Seq_H3396_Human1.67238997
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.66685359
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.64339940
32TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.63962536
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.63710714
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.63558055
35DROSHA_22980978_ChIP-Seq_HELA_Human1.63471017
36AR_25329375_ChIP-Seq_VCAP_Human1.63405349
37RAC3_21632823_ChIP-Seq_H3396_Human1.58940827
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.58589288
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.57883186
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57057097
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.53651603
42P300_19829295_ChIP-Seq_ESCs_Human1.52879408
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50767447
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.50184561
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49164758
46MYC_19829295_ChIP-Seq_ESCs_Human1.49130092
47GATA3_21867929_ChIP-Seq_CD8_Mouse1.48174043
48GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47169366
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.45647760
50TAL1_26923725_Chip-Seq_HPCs_Mouse1.44850107
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.44652336
52SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43100946
53ARNT_22903824_ChIP-Seq_MCF-7_Human1.39767999
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39000044
55RUNX2_22187159_ChIP-Seq_PCA_Human1.37834617
56KDM2B_26808549_Chip-Seq_REH_Human1.36691864
57OCT4_20526341_ChIP-Seq_ESCs_Human1.36625883
58STAT3_23295773_ChIP-Seq_U87_Human1.36179531
59TAF2_19829295_ChIP-Seq_ESCs_Human1.35926666
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35782263
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35480776
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34894411
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34359132
64CBP_20019798_ChIP-Seq_JUKART_Human1.33443477
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33443477
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.29272447
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28994883
68GBX2_23144817_ChIP-Seq_PC3_Human1.27888856
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.27733826
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.26980671
71CTCF_20526341_ChIP-Seq_ESCs_Human1.26133768
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25012905
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24865404
74SMAD4_21799915_ChIP-Seq_A2780_Human1.24646444
75TCF4_23295773_ChIP-Seq_U87_Human1.24273520
76SMAD3_21741376_ChIP-Seq_ESCs_Human1.23919693
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.22982094
78RNF2_27304074_Chip-Seq_NSC_Mouse1.21768617
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21635443
80BCL6_27268052_Chip-Seq_Bcells_Human1.21513866
81SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.21003561
82TBL1_22424771_ChIP-Seq_293T_Human1.18891695
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18844780
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18767909
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.18697665
86RBPJ_21746931_ChIP-Seq_IB4_Human1.17976138
87TAF15_26573619_Chip-Seq_HEK293_Human1.17802984
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17634607
89P53_21459846_ChIP-Seq_SAOS-2_Human1.17248170
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.16761571
91REST_21632747_ChIP-Seq_MESCs_Mouse1.15307029
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.15166410
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.14752841
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14611761
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14611761
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.14461118
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14461118
98TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.14174721
99FOXH1_21741376_ChIP-Seq_EPCs_Human1.13822311
100NFYB_21822215_ChIP-Seq_K562_Human1.12598972
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11839164
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11476324
103ETV1_20927104_ChIP-Seq_GIST48_Human1.11055893
104RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10881247
105GF1_26923725_Chip-Seq_HPCs_Mouse1.10332480
106CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10271653
107OCT4_18555785_Chip-Seq_ESCs_Mouse1.09846665
108CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08501035
109GATA3_26560356_Chip-Seq_TH1_Human1.08093582
110CEBPB_22108803_ChIP-Seq_LS180_Human1.07772889
111E2F1_20622854_ChIP-Seq_HELA_Human1.07334902
112SOX2_19829295_ChIP-Seq_ESCs_Human1.07022990
113NANOG_19829295_ChIP-Seq_ESCs_Human1.07022990
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06886215
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06547749
116SMC4_20622854_ChIP-Seq_HELA_Human1.06534374
117HNFA_21074721_ChIP-Seq_CACO-2_Human1.06019175
118CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05210260
119SMAD4_21741376_ChIP-Seq_HESCs_Human1.04607808
120BCOR_27268052_Chip-Seq_Bcells_Human1.04602478
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04452554
122P53_22387025_ChIP-Seq_ESCs_Mouse1.04416096
123RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04366481
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03955990
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.03276412
126CBP_21632823_ChIP-Seq_H3396_Human1.02971861
127P68_20966046_ChIP-Seq_HELA_Human1.02668861
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02619484
129NCOR_22424771_ChIP-Seq_293T_Human1.02563485
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02379214
131E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02158873
132KLF4_19829295_ChIP-Seq_ESCs_Human1.02148645
133PHF8_20622854_ChIP-Seq_HELA_Human1.02081304
134SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02069893
135CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01531234
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01324058
137ERG_20517297_ChIP-Seq_VCAP_Human1.01139388
138OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01124174
139SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00444600
140SALL4_22934838_ChIP-ChIP_CD34+_Human1.00101318
141KLF4_18555785_Chip-Seq_ESCs_Mouse0.99948652
142KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99946740
143ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99909991
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99908155
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99150994
146TP63_22573176_ChIP-Seq_HFKS_Human0.99029950
147SMRT_27268052_Chip-Seq_Bcells_Human0.98900620
148TP53_18474530_ChIP-ChIP_U2OS_Human0.98890995
149P300_18555785_Chip-Seq_ESCs_Mouse0.97959174
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97697252
151TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97089447
152SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97064163
153ESET_19884257_ChIP-Seq_ESCs_Mouse0.96771647
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.96536126
155PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96208971
156ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94903808
157EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93926294
158CMYC_18555785_Chip-Seq_ESCs_Mouse0.93736582
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.93106718
160STAT3_18555785_Chip-Seq_ESCs_Mouse0.92504132
161CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92481669
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92388020
163RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92341017
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.91859113
165RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90896445
166RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90688261
167LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89803230
168SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89052906
169PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88025748
170EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87687570
171FLI1_21867929_ChIP-Seq_CD8_Mouse0.87034392
172MYC_27129775_Chip-Seq_CORNEA_Mouse0.86982174
173PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85794923
174PU1_27457419_Chip-Seq_LIVER_Mouse0.85532026
175SOX9_26525672_Chip-Seq_HEART_Mouse0.84559155

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06231450
2MP0001929_abnormal_gametogenesis5.68224224
3MP0008877_abnormal_DNA_methylation5.43920681
4MP0003718_maternal_effect4.91418981
5MP0002210_abnormal_sex_determination3.92659437
6MP0002161_abnormal_fertility/fecundity3.29182358
7MP0001145_abnormal_male_reproductive3.26844489
8MP0006292_abnormal_olfactory_placode3.21284831
9MP0008789_abnormal_olfactory_epithelium2.90789325
10MP0000653_abnormal_sex_gland2.86111520
11MP0002653_abnormal_ependyma_morphology2.75986084
12MP0005499_abnormal_olfactory_system2.44033323
13MP0005394_taste/olfaction_phenotype2.44033323
14MP0001348_abnormal_lacrimal_gland2.39394676
15MP0000678_abnormal_parathyroid_gland2.20275880
16MP0005670_abnormal_white_adipose2.09940853
17MP0005410_abnormal_fertilization15.4137498
18MP0002160_abnormal_reproductive_system1.99030808
19MP0005395_other_phenotype1.94887957
20MP0008004_abnormal_stomach_pH1.80077666
21MP0008057_abnormal_DNA_replication1.78895493
22MP0005623_abnormal_meninges_morphology1.70377007
23MP0003646_muscle_fatigue1.62647671
24MP0008058_abnormal_DNA_repair1.54341337
25MP0002138_abnormal_hepatobiliary_system1.46452684
26MP0001485_abnormal_pinna_reflex1.43780662
27MP0001486_abnormal_startle_reflex1.42516992
28MP0005379_endocrine/exocrine_gland_phen1.41332491
29MP0010094_abnormal_chromosome_stability1.32916017
30MP0002282_abnormal_trachea_morphology1.22455121
31MP0005423_abnormal_somatic_nervous1.22452082
32MP0008995_early_reproductive_senescence1.20911977
33MP0005647_abnormal_sex_gland1.18022367
34MP0004233_abnormal_muscle_weight1.14084221
35MP0005360_urolithiasis1.10714250
36MP0001984_abnormal_olfaction1.10221628
37MP0001963_abnormal_hearing_physiology1.09590348
38MP0002132_abnormal_respiratory_system1.09401635
39MP0005389_reproductive_system_phenotype1.04205227
40MP0003011_delayed_dark_adaptation1.03825964
41MP0003786_premature_aging1.02267322
42MP0002127_abnormal_cardiovascular_syste1.02046269
43MP0008007_abnormal_cellular_replicative0.98861876
44MP0002249_abnormal_larynx_morphology0.98193523
45MP0000026_abnormal_inner_ear0.95772601
46MP0001765_abnormal_ion_homeostasis0.89923912
47MP0000049_abnormal_middle_ear0.89794172
48MP0009046_muscle_twitch0.86156654
49MP0006276_abnormal_autonomic_nervous0.84885396
50MP0003111_abnormal_nucleus_morphology0.80325260
51MP0002735_abnormal_chemical_nociception0.77989945
52MP0000569_abnormal_digit_pigmentation0.77539569
53MP0001986_abnormal_taste_sensitivity0.76065213
54MP0001666_abnormal_nutrient_absorption0.74320725
55MP0000631_abnormal_neuroendocrine_gland0.73771985
56MP0005310_abnormal_salivary_gland0.73563727
57MP0009379_abnormal_foot_pigmentation0.72369687
58MP0001968_abnormal_touch/_nociception0.71567210
59MP0002557_abnormal_social/conspecific_i0.71533861
60MP0000372_irregular_coat_pigmentation0.70767735
61MP0002272_abnormal_nervous_system0.70007751
62MP0002067_abnormal_sensory_capabilities0.69150404
63MP0000566_synostosis0.65507135
64MP0005397_hematopoietic_system_phenotyp0.64454504
65MP0001545_abnormal_hematopoietic_system0.64454504
66MP0009278_abnormal_bone_marrow0.63670351
67MP0002822_catalepsy0.63512172
68MP0002229_neurodegeneration0.63176060
69MP0003119_abnormal_digestive_system0.62764130
70MP0003699_abnormal_female_reproductive0.61436381
71MP0005377_hearing/vestibular/ear_phenot0.61372765
72MP0003878_abnormal_ear_physiology0.61372765
73MP0003115_abnormal_respiratory_system0.58241464
74MP0005408_hypopigmentation0.58186426
75MP0002234_abnormal_pharynx_morphology0.55292899
76MP0001119_abnormal_female_reproductive0.54824164
77MP0004134_abnormal_chest_morphology0.53723247
78MP0009053_abnormal_anal_canal0.53008854
79MP0000358_abnormal_cell_content/0.52981928
80MP0004859_abnormal_synaptic_plasticity0.52906031
81MP0002233_abnormal_nose_morphology0.52727072
82MP0009697_abnormal_copulation0.52701498
83MP0010307_abnormal_tumor_latency0.51433821
84MP0010368_abnormal_lymphatic_system0.51293964
85MP0005646_abnormal_pituitary_gland0.51113044
86MP0001664_abnormal_digestion0.50863154
87MP0000230_abnormal_systemic_arterial0.50437826
88MP0000955_abnormal_spinal_cord0.49829513
89MP0002572_abnormal_emotion/affect_behav0.49166323
90MP0004084_abnormal_cardiac_muscle0.48732250
91MP0003077_abnormal_cell_cycle0.48490868
92MP0004808_abnormal_hematopoietic_stem0.47578468
93MP0005636_abnormal_mineral_homeostasis0.45336448
94MP0001730_embryonic_growth_arrest0.44308509
95MP0000470_abnormal_stomach_morphology0.44015345
96MP0002928_abnormal_bile_duct0.43607395
97MP0003136_yellow_coat_color0.42981153
98MP0009745_abnormal_behavioral_response0.42033383
99MP0003950_abnormal_plasma_membrane0.41109545
100MP0001293_anophthalmia0.40629502
101MP0001324_abnormal_eye_pigmentation0.40270930
102MP0005451_abnormal_body_composition0.40156508
103MP0004036_abnormal_muscle_relaxation0.39806587
104MP0005666_abnormal_adipose_tissue0.39762956
105MP0003183_abnormal_peptide_metabolism0.39624512
106MP0003890_abnormal_embryonic-extraembry0.39236562
107MP0004085_abnormal_heartbeat0.39136880
108MP0005253_abnormal_eye_physiology0.38898048
109MP0002102_abnormal_ear_morphology0.37575698
110MP0000681_abnormal_thyroid_gland0.37574604
111MP0002733_abnormal_thermal_nociception0.36441625
112MP0006036_abnormal_mitochondrial_physio0.35730650
113MP0005551_abnormal_eye_electrophysiolog0.35205314
114MP0003693_abnormal_embryo_hatching0.34202746
115MP0001764_abnormal_homeostasis0.33729202
116MP0005391_vision/eye_phenotype0.33717928
117MP0004019_abnormal_vitamin_homeostasis0.33144877
118MP0002269_muscular_atrophy0.30920987
119MP0000313_abnormal_cell_death0.30458144
120MP0003861_abnormal_nervous_system0.29337048
121MP0004133_heterotaxia0.28996385
122MP0001727_abnormal_embryo_implantation0.28575393
123MP0000534_abnormal_ureter_morphology0.26904904
124MP0000427_abnormal_hair_cycle0.25633037
125MP0009115_abnormal_fat_cell0.24977423
126MP0002084_abnormal_developmental_patter0.23955066
127MP0002092_abnormal_eye_morphology0.23337296
128MP0003329_amyloid_beta_deposits0.22734743
129MP0003942_abnormal_urinary_system0.22100035
130MP0006072_abnormal_retinal_apoptosis0.21499198
131MP0002152_abnormal_brain_morphology0.21303198
132MP0002169_no_abnormal_phenotype0.21130237
133MP0001672_abnormal_embryogenesis/_devel0.20919244
134MP0005380_embryogenesis_phenotype0.20919244
135MP0002873_normal_phenotype0.20753812
136MP0003936_abnormal_reproductive_system0.20662339
137MP0000432_abnormal_head_morphology0.17515113
138MP0002736_abnormal_nociception_after0.17299905
139MP0002971_abnormal_brown_adipose0.17096248
140MP0001697_abnormal_embryo_size0.17049672
141MP0004811_abnormal_neuron_physiology0.16784555
142MP0001661_extended_life_span0.15380837
143MP0002796_impaired_skin_barrier0.14971627
144MP0004742_abnormal_vestibular_system0.14953510
145MP0002085_abnormal_embryonic_tissue0.14809022
146MP0003879_abnormal_hair_cell0.14275565
147MP0002080_prenatal_lethality0.13951076
148MP0000001_mammalian_phenotype0.13856584
149MP0003633_abnormal_nervous_system0.13774030
150MP0003787_abnormal_imprinting0.13498611
151MP0000647_abnormal_sebaceous_gland0.13011594
152MP0002139_abnormal_hepatobiliary_system0.12946643
153MP0003984_embryonic_growth_retardation0.12533571
154MP0001919_abnormal_reproductive_system0.12296813
155MP0003631_nervous_system_phenotype0.11038476
156MP0006035_abnormal_mitochondrial_morpho0.10973114
157MP0003948_abnormal_gas_homeostasis0.10890465
158MP0004264_abnormal_extraembryonic_tissu0.10451426

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.57476166
2Abnormal respiratory epithelium morphology (HP:0012253)8.92013532
3Abnormal respiratory motile cilium morphology (HP:0005938)8.92013532
4Rhinitis (HP:0012384)7.84212350
5Abnormal ciliary motility (HP:0012262)7.79372431
6Chronic bronchitis (HP:0004469)7.32156023
7Infertility (HP:0000789)6.56677733
8Nasal polyposis (HP:0100582)6.17582639
9Severe visual impairment (HP:0001141)5.37240520
10Chronic hepatic failure (HP:0100626)5.25907945
11Abnormality of the nasal mucosa (HP:0000433)5.04391750
12Cone-rod dystrophy (HP:0000548)4.86817991
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.56556159
14Bronchiectasis (HP:0002110)4.53149475
15Nephronophthisis (HP:0000090)4.50997884
16Bronchitis (HP:0012387)4.39167893
17Asymmetric septal hypertrophy (HP:0001670)4.22427277
18Attenuation of retinal blood vessels (HP:0007843)3.88194077
19Bony spicule pigmentary retinopathy (HP:0007737)3.87995106
20Male infertility (HP:0003251)3.84529045
21Osteomalacia (HP:0002749)3.62633785
22Resting tremor (HP:0002322)3.56885129
23Abnormal spermatogenesis (HP:0008669)3.56015792
24Abnormality of macular pigmentation (HP:0008002)3.45544065
25Abnormality of the renal medulla (HP:0100957)3.42705978
26Aplasia/Hypoplasia of the earlobes (HP:0009906)3.41073405
27Recurrent sinusitis (HP:0011108)3.37259669
28Abnormality of the lower motor neuron (HP:0002366)3.29059406
29Recurrent otitis media (HP:0000403)3.18898230
30Oligodactyly (hands) (HP:0001180)3.13660073
31Abnormality of abdominal situs (HP:0011620)3.03095367
32Abdominal situs inversus (HP:0003363)3.03095367
33Hyperkalemia (HP:0002153)3.01160556
34Portal hypertension (HP:0001409)2.94853962
35Tubulointerstitial nephritis (HP:0001970)2.93996451
36Gonadotropin excess (HP:0000837)2.92707709
37Spontaneous abortion (HP:0005268)2.87640014
38Abnormality of dental color (HP:0011073)2.87538635
39Amelogenesis imperfecta (HP:0000705)2.83095755
40Hypophosphatemic rickets (HP:0004912)2.83066853
41Truncal obesity (HP:0001956)2.81232686
42Abnormality of midbrain morphology (HP:0002418)2.77908233
43Molar tooth sign on MRI (HP:0002419)2.77908233
44Optic nerve hypoplasia (HP:0000609)2.75584652
45Abnormality of the hepatic vasculature (HP:0006707)2.69926371
46Azoospermia (HP:0000027)2.69815093
47Tubular atrophy (HP:0000092)2.62274149
48Sensory axonal neuropathy (HP:0003390)2.56576645
49Medial flaring of the eyebrow (HP:0010747)2.53127114
50Intellectual disability, moderate (HP:0002342)2.51462390
51Amyotrophic lateral sclerosis (HP:0007354)2.47915842
52Tubulointerstitial abnormality (HP:0001969)2.47860025
53Anterior segment dysgenesis (HP:0007700)2.47765747
54Hypoplastic ischia (HP:0003175)2.46376549
55Impulsivity (HP:0100710)2.45411459
56Potter facies (HP:0002009)2.44833646
57Facial shape deformation (HP:0011334)2.44833646
58Progressive cerebellar ataxia (HP:0002073)2.44803705
59Recurrent bronchitis (HP:0002837)2.43842473
60Postural instability (HP:0002172)2.41864300
61Congenital sensorineural hearing impairment (HP:0008527)2.41417463
62Fibular hypoplasia (HP:0003038)2.41128545
63Menstrual irregularities (HP:0000858)2.35869461
64Abnormal rod and cone electroretinograms (HP:0008323)2.31312607
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30641360
66Facial hemangioma (HP:0000329)2.29643617
67Generalized aminoaciduria (HP:0002909)2.28766353
68Hypoalphalipoproteinemia (HP:0003233)2.28717308
69Insulin-resistant diabetes mellitus (HP:0000831)2.24327754
70Postaxial foot polydactyly (HP:0001830)2.20375439
71Enlarged epiphyses (HP:0010580)2.18809645
72Oligodactyly (HP:0012165)2.14169067
73Abnormality of the ischium (HP:0003174)2.14139617
74Impaired proprioception (HP:0010831)2.06560562
75Subcapsular cataract (HP:0000523)2.04149765
76Abnormality of the labia minora (HP:0012880)2.00262497
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.00154183
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4024826
79Dynein arm defect of respiratory motile cilia (HP:0012255)12.8795483
80Absent/shortened dynein arms (HP:0200106)12.8795483
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.98576812
82Congenital hepatic fibrosis (HP:0002612)1.98303278
83Stage 5 chronic kidney disease (HP:0003774)1.97198345
84Septo-optic dysplasia (HP:0100842)1.97017830
85Progressive sensorineural hearing impairment (HP:0000408)1.96564498
86Tubulointerstitial fibrosis (HP:0005576)1.95816669
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95649970
88Hypoplasia of the fovea (HP:0007750)1.94396135
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.94396135
90Abnormality of the renal cortex (HP:0011035)1.86682797
91Maternal diabetes (HP:0009800)1.83632789
92Upper limb muscle weakness (HP:0003484)1.83306677
93Oculomotor apraxia (HP:0000657)1.83215531
94Polydipsia (HP:0001959)1.82534206
95Abnormal drinking behavior (HP:0030082)1.82534206
96Hypoplasia of the thymus (HP:0000778)1.82029643
97Short ribs (HP:0000773)1.81919101
98Photophobia (HP:0000613)1.81807697
99Short tibia (HP:0005736)1.79743377
100Facial cleft (HP:0002006)1.79375761
101Lip pit (HP:0100267)1.78327594
102Abnormality of the fovea (HP:0000493)1.77128806
103Upper motor neuron abnormality (HP:0002127)1.76197696
104Microglossia (HP:0000171)1.75559853
105Sandal gap (HP:0001852)1.75425761
106Renal dysplasia (HP:0000110)1.75356304
107Aplasia/Hypoplasia of the tibia (HP:0005772)1.74065652
108Renovascular hypertension (HP:0100817)1.72455107
109Abnormality of the anterior horn cell (HP:0006802)1.70518236
110Degeneration of anterior horn cells (HP:0002398)1.70518236
111Increased purine levels (HP:0004368)1.69347887
112Taurodontia (HP:0000679)1.67217963
113Abnormality of permanent molar morphology (HP:0011071)1.67217963
114Abnormality of the dental root (HP:0006486)1.67217963
115Abnormality of dentin (HP:0010299)1.66900673
116Supernumerary spleens (HP:0009799)1.66739260
117Median cleft lip (HP:0000161)1.65813596
118Dyschromatopsia (HP:0007641)1.63622328
119Spastic tetraparesis (HP:0001285)1.61394599
120Postaxial hand polydactyly (HP:0001162)1.61305761
121Absent frontal sinuses (HP:0002688)1.60365227
122Cholecystitis (HP:0001082)1.60133709
123Abnormal gallbladder physiology (HP:0012438)1.60133709
124Abnormality of renal excretion (HP:0011036)1.56247142
125Abnormality of molar (HP:0011077)1.56232265
126Abnormality of molar morphology (HP:0011070)1.56232265
127Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56039141
128Absent epiphyses (HP:0010577)1.56039141
129Pancreatic fibrosis (HP:0100732)1.55153990
130Heterotopia (HP:0002282)1.54828961
131Decreased central vision (HP:0007663)1.52897462
132Abnormality of the dental pulp (HP:0006479)1.52839471
133J-shaped sella turcica (HP:0002680)1.52789026
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.52648240
135Cystic liver disease (HP:0006706)1.52295833
136Bell-shaped thorax (HP:0001591)1.51540744
137Short thorax (HP:0010306)1.50833583
138Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.49455132
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.48704449
14011 pairs of ribs (HP:0000878)1.43649779
141Chronic sinusitis (HP:0011109)1.42849572
142Abnormal biliary tract physiology (HP:0012439)1.39830563
143Bile duct proliferation (HP:0001408)1.39830563
144Nephropathy (HP:0000112)1.34046544
145Choroideremia (HP:0001139)1.31723471
146Deformed sella turcica (HP:0002681)1.30662273
147Congenital primary aphakia (HP:0007707)1.30161521
148Breast carcinoma (HP:0003002)1.29314671
149True hermaphroditism (HP:0010459)1.29260720
150Gait imbalance (HP:0002141)1.28365576
151Broad distal phalanx of finger (HP:0009836)1.26666133
152Aplasia/Hypoplasia of the lens (HP:0008063)1.26523370
153Abnormal urine output (HP:0012590)1.24292478
154Hemorrhage of the eye (HP:0011885)1.23726573
155Abnormality of ocular smooth pursuit (HP:0000617)1.22736270
156Short femoral neck (HP:0100864)1.21048925
157Cerebellar dysplasia (HP:0007033)1.18351192
158Hypoplasia of dental enamel (HP:0006297)1.16773967
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.16357425
160Pachygyria (HP:0001302)1.16038270
161Decreased motor nerve conduction velocity (HP:0003431)1.14437312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.85029573
2PDK48.85029573
3PDK25.77046636
4TESK15.00867876
5PRKD34.02365963
6INSRR3.53203758
7PLK23.51307305
8ICK3.50135555
9MAP3K93.04426984
10BRD42.79429975
11DDR22.72414981
12PTK2B2.44754098
13ARAF2.37125339
14WNK42.22420767
15CDK192.19954304
16MAP3K132.19145889
17PNCK2.17328054
18STK392.12772908
19PIK3CG1.97632210
20NEK21.96887491
21TIE11.80791691
22NTRK31.78490767
23MAP4K21.60461881
24STK381.50316168
25EEF2K1.31302523
26CDK71.31173995
27KSR21.22250797
28CAMK1D1.20235579
29MOS1.03532957
30DYRK1B1.00920414
31DYRK31.00519135
32MET0.99356876
33PDK10.98027562
34MAPK150.96771932
35STK30.95611085
36CDC70.92744285
37TTK0.89826560
38WNK10.87861647
39CCNB10.87667736
40TYRO30.87325043
41PASK0.84743566
42TAOK30.80076533
43NEK90.77282943
44VRK10.76190788
45CAMK10.74902633
46CDK90.74738701
47STK38L0.74480480
48EPHA20.71959647
49MAPKAPK30.69890384
50MST1R0.69762265
51PINK10.69686165
52WEE10.67146209
53OXSR10.66435123
54MAP3K80.63294128
55CHEK20.61796237
56IRAK10.61310804
57TNIK0.60861385
58ATR0.55471391
59CHEK10.54593693
60PRKAA20.53884447
61STK240.52780879
62MAPKAPK50.48877520
63LATS20.46982997
64PLK40.45822836
65CAMK1G0.45306241
66PDPK10.44802099
67ZAK0.44532966
68AKT30.44250042
69TESK20.43088369
70SIK20.42591212
71LATS10.41038624
72PRKCI0.39779014
73NUAK10.38735809
74ATM0.37542332
75LMTK20.37059347
76PRKG20.36407006
77PLK10.35525000
78MAP2K60.34178468
79NTRK20.33832653
80MAP2K20.32934821
81MUSK0.31286570
82SGK10.30997875
83BRSK20.30810756
84PAK10.30474331
85RAF10.27121597
86PRKAA10.26683274
87MTOR0.26212044
88PKN10.26175026
89IRAK20.25647752
90PRKACA0.24841574
91BRAF0.22845106
92PRKCG0.22774038
93RPS6KB10.22571102
94CAMK40.21309709
95TLK10.20853399
96MAPK130.20425218
97CAMKK10.19639529
98SGK2230.19207612
99SGK4940.19207612
100RPS6KA20.18855168
101MARK20.17200373
102ROCK10.16783757
103PAK20.15825067
104BRSK10.15644854
105CDK50.15474158
106RIPK40.15453218
107NEK60.14218206
108BMPR1B0.13844390
109CDK30.13633348
110CDK120.11977199
111MAP2K70.08471270
112CSNK2A10.08156531
113CDK10.07578947
114MAP3K40.07145668
115CDK20.06437948
116WNK30.06041610
117AURKA0.05637696
118RPS6KA10.05632747
119PAK40.05303652
120MARK30.05154621
121GSK3B0.04007115
122STK110.03773309
123CSNK1D0.03645613
124PRKCZ0.03598534
125CDK150.02974749
126MAPK80.02824692
127CDK40.02805205
128MAP3K50.02252588
129TAOK10.02219346
130CSNK2A20.01887282
131PRKDC0.01762552
132MAP3K100.01610976
133CDK11A0.01486817
134CDK180.01124338
135PRKCQ0.00195794
136CDK6-0.0463372
137MAPK10-0.0452157
138PIM1-0.0444647
139CDK14-0.0410880
140MAPK1-0.0404933
141PRKCB-0.0383240
142CASK-0.0340304
143EIF2AK1-0.0328248
144BUB1-0.0280572
145PRKACB-0.0265706
146PRKG1-0.0207061
147CAMK2A-0.0146315
148STK10-0.0136098
149PRKACG-0.0079990
150AURKB-0.0033861

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.16953990
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.78366684
3Olfactory transduction_Homo sapiens_hsa047404.42970783
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.15423165
5Pyruvate metabolism_Homo sapiens_hsa006204.09173231
6Fatty acid biosynthesis_Homo sapiens_hsa000613.41344514
7Propanoate metabolism_Homo sapiens_hsa006403.24328321
8Basal transcription factors_Homo sapiens_hsa030223.12147398
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.85326852
10Glucagon signaling pathway_Homo sapiens_hsa049222.84774712
11Linoleic acid metabolism_Homo sapiens_hsa005912.80597415
12Fanconi anemia pathway_Homo sapiens_hsa034602.49243303
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.44734384
14Pentose phosphate pathway_Homo sapiens_hsa000302.38154880
15Selenocompound metabolism_Homo sapiens_hsa004502.37943780
16Oocyte meiosis_Homo sapiens_hsa041142.00031350
17Dorso-ventral axis formation_Homo sapiens_hsa043201.98681593
18Glycerolipid metabolism_Homo sapiens_hsa005611.88562881
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80750712
20Phototransduction_Homo sapiens_hsa047441.78380577
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63156736
22Butanoate metabolism_Homo sapiens_hsa006501.63119678
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.62558416
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.62063680
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.61575722
26Amphetamine addiction_Homo sapiens_hsa050311.59613329
27PPAR signaling pathway_Homo sapiens_hsa033201.57103823
28Huntingtons disease_Homo sapiens_hsa050161.49861016
29mRNA surveillance pathway_Homo sapiens_hsa030151.45863462
30Fructose and mannose metabolism_Homo sapiens_hsa000511.44430399
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42409991
32RNA transport_Homo sapiens_hsa030131.41867732
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.41547776
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33463807
35Mismatch repair_Homo sapiens_hsa034301.32435426
36Carbon metabolism_Homo sapiens_hsa012001.31927951
37Ether lipid metabolism_Homo sapiens_hsa005651.30363577
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27908294
39Caffeine metabolism_Homo sapiens_hsa002321.23376599
40Phenylalanine metabolism_Homo sapiens_hsa003601.18435688
41Purine metabolism_Homo sapiens_hsa002301.17175664
42Fat digestion and absorption_Homo sapiens_hsa049751.15902406
43Renin secretion_Homo sapiens_hsa049241.14541939
44Nitrogen metabolism_Homo sapiens_hsa009101.13556952
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12771099
46Cardiac muscle contraction_Homo sapiens_hsa042601.10947222
47Nicotine addiction_Homo sapiens_hsa050331.06952053
48Base excision repair_Homo sapiens_hsa034101.03493275
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01839091
50Antigen processing and presentation_Homo sapiens_hsa046121.01233169
51Nucleotide excision repair_Homo sapiens_hsa034200.97991593
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97889891
53Ovarian steroidogenesis_Homo sapiens_hsa049130.96533877
54Mineral absorption_Homo sapiens_hsa049780.95796603
55Biosynthesis of amino acids_Homo sapiens_hsa012300.95370238
56Morphine addiction_Homo sapiens_hsa050320.94222984
57Gap junction_Homo sapiens_hsa045400.92761555
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92473943
59Fatty acid metabolism_Homo sapiens_hsa012120.91694755
60Glutathione metabolism_Homo sapiens_hsa004800.90096274
61Serotonergic synapse_Homo sapiens_hsa047260.89348580
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89306100
63Fatty acid degradation_Homo sapiens_hsa000710.88629779
64Glutamatergic synapse_Homo sapiens_hsa047240.87768647
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80865382
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77261261
67Type II diabetes mellitus_Homo sapiens_hsa049300.76382537
68Long-term potentiation_Homo sapiens_hsa047200.75484518
69Tyrosine metabolism_Homo sapiens_hsa003500.75470493
70Arachidonic acid metabolism_Homo sapiens_hsa005900.75218472
71Chemical carcinogenesis_Homo sapiens_hsa052040.71820719
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68145892
73Circadian rhythm_Homo sapiens_hsa047100.67642116
74ABC transporters_Homo sapiens_hsa020100.67237425
75Homologous recombination_Homo sapiens_hsa034400.67020202
76Regulation of autophagy_Homo sapiens_hsa041400.66200065
77Collecting duct acid secretion_Homo sapiens_hsa049660.65977790
78Hedgehog signaling pathway_Homo sapiens_hsa043400.64973266
79Sulfur relay system_Homo sapiens_hsa041220.63637507
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63326992
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60888174
82Circadian entrainment_Homo sapiens_hsa047130.60811478
83Cell cycle_Homo sapiens_hsa041100.60348216
84RNA degradation_Homo sapiens_hsa030180.60143392
85Estrogen signaling pathway_Homo sapiens_hsa049150.59793691
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56966080
87GABAergic synapse_Homo sapiens_hsa047270.56870598
88Systemic lupus erythematosus_Homo sapiens_hsa053220.54469694
89Pyrimidine metabolism_Homo sapiens_hsa002400.54304369
90Arginine and proline metabolism_Homo sapiens_hsa003300.53543418
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.53241174
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51058081
93Oxytocin signaling pathway_Homo sapiens_hsa049210.50491996
94Calcium signaling pathway_Homo sapiens_hsa040200.49358211
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.48442125
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46473136
97AMPK signaling pathway_Homo sapiens_hsa041520.46440377
98Long-term depression_Homo sapiens_hsa047300.45320788
99VEGF signaling pathway_Homo sapiens_hsa043700.44928834
100Choline metabolism in cancer_Homo sapiens_hsa052310.44775144
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43069285
102Gastric acid secretion_Homo sapiens_hsa049710.41947750
103MAPK signaling pathway_Homo sapiens_hsa040100.41319240
104Autoimmune thyroid disease_Homo sapiens_hsa053200.41209619
105Thyroid hormone synthesis_Homo sapiens_hsa049180.40675091
106ECM-receptor interaction_Homo sapiens_hsa045120.39853179
107Insulin secretion_Homo sapiens_hsa049110.39668742
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39576301
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39311818
110Cholinergic synapse_Homo sapiens_hsa047250.38879982
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.37752180
112Metabolic pathways_Homo sapiens_hsa011000.37424001
113mTOR signaling pathway_Homo sapiens_hsa041500.36949250
114Legionellosis_Homo sapiens_hsa051340.36586781
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36468270
116Inositol phosphate metabolism_Homo sapiens_hsa005620.36345639
117Type I diabetes mellitus_Homo sapiens_hsa049400.35536937
118Adherens junction_Homo sapiens_hsa045200.35340995
119Renin-angiotensin system_Homo sapiens_hsa046140.35289330
120Tight junction_Homo sapiens_hsa045300.35204217
121Allograft rejection_Homo sapiens_hsa053300.34334519
122Endocytosis_Homo sapiens_hsa041440.34248154
123Arginine biosynthesis_Homo sapiens_hsa002200.33419817
124DNA replication_Homo sapiens_hsa030300.32330570
125Bile secretion_Homo sapiens_hsa049760.29265258
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.25766925
127Viral carcinogenesis_Homo sapiens_hsa052030.24251751
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24052404
129Alcoholism_Homo sapiens_hsa050340.23951630
130Wnt signaling pathway_Homo sapiens_hsa043100.22129889
131Retinol metabolism_Homo sapiens_hsa008300.21967719
132Synaptic vesicle cycle_Homo sapiens_hsa047210.21927842
133N-Glycan biosynthesis_Homo sapiens_hsa005100.21781371
134Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21305786
135Pancreatic secretion_Homo sapiens_hsa049720.20152357
136Taste transduction_Homo sapiens_hsa047420.17970373
137Non-homologous end-joining_Homo sapiens_hsa034500.16806092
138Epstein-Barr virus infection_Homo sapiens_hsa051690.15967645
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15243119
140cAMP signaling pathway_Homo sapiens_hsa040240.14828860
141Protein digestion and absorption_Homo sapiens_hsa049740.14590729
142Spliceosome_Homo sapiens_hsa030400.11743009
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.11541702
144Salivary secretion_Homo sapiens_hsa049700.11440921
145B cell receptor signaling pathway_Homo sapiens_hsa046620.11007061

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