SSPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.57172948
2cardiac myofibril assembly (GO:0055003)7.55360987
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.35147724
4myofibril assembly (GO:0030239)6.76177068
5negative regulation of potassium ion transmembrane transport (GO:1901380)6.55195583
6actin-myosin filament sliding (GO:0033275)6.44839690
7muscle filament sliding (GO:0030049)6.44839690
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.89805901
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.85348188
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.76744209
11plasma membrane repair (GO:0001778)5.55855497
12response to muscle activity (GO:0014850)5.53866388
13actin-mediated cell contraction (GO:0070252)5.53859614
14tricarboxylic acid cycle (GO:0006099)5.46687172
15cardiac muscle contraction (GO:0060048)5.46383706
16regulation of skeletal muscle contraction (GO:0014819)5.38126307
17cardiac muscle cell development (GO:0055013)5.31985611
18regulation of relaxation of muscle (GO:1901077)5.29286362
19regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.10898003
20regulation of actin filament-based movement (GO:1903115)5.06935559
21actomyosin structure organization (GO:0031032)5.05916451
22regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.04539114
23cardiac cell development (GO:0055006)5.00577968
24carnitine shuttle (GO:0006853)4.99546106
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.79870409
26heart trabecula formation (GO:0060347)4.70662265
27regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.70656018
28cardiac muscle tissue morphogenesis (GO:0055008)4.68483864
29sarcoplasmic reticulum calcium ion transport (GO:0070296)4.65211241
30ventricular cardiac muscle cell action potential (GO:0086005)4.64485708
31regulation of sarcomere organization (GO:0060297)4.63468628
32regulation of cell communication by electrical coupling (GO:0010649)4.57879575
33adult heart development (GO:0007512)4.55974225
34regulation of acyl-CoA biosynthetic process (GO:0050812)4.54798841
35cardiac muscle hypertrophy (GO:0003300)4.49629441
36striated muscle contraction (GO:0006941)4.48483738
37ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.48071688
38fatty acid transmembrane transport (GO:1902001)4.43520629
39bundle of His cell to Purkinje myocyte communication (GO:0086069)4.39624154
40muscle cell cellular homeostasis (GO:0046716)4.34639567
41striated muscle hypertrophy (GO:0014897)4.33995009
42regulation of striated muscle contraction (GO:0006942)4.30895998
43muscle tissue morphogenesis (GO:0060415)4.28393962
44regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.27940999
45actin filament-based movement (GO:0030048)4.23931229
46regulation of membrane repolarization (GO:0060306)4.20034306
47negative regulation of protein localization to cell surface (GO:2000009)4.14812029
48skeletal muscle fiber development (GO:0048741)4.13795204
49regulation of coenzyme metabolic process (GO:0051196)4.08307423
50regulation of cofactor metabolic process (GO:0051193)4.08307423
51myotube cell development (GO:0014904)4.02262470
52creatine metabolic process (GO:0006600)4.01044636
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.96531206
54regulation of sequestering of triglyceride (GO:0010889)3.88038580
55cell communication involved in cardiac conduction (GO:0086065)3.85371574
56heart contraction (GO:0060047)3.81425690
57heart process (GO:0003015)3.81425690
58regulation of the force of heart contraction (GO:0002026)3.79824434
59muscle hypertrophy (GO:0014896)3.77738789
60skeletal muscle tissue development (GO:0007519)3.76985758
61peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.73610119
62response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.71326518
63muscle fiber development (GO:0048747)3.66363745
64carnitine transmembrane transport (GO:1902603)3.66277337
65regulation of cardiac muscle contraction (GO:0055117)3.63866827
66regulation of cardiac muscle cell contraction (GO:0086004)3.55558647
67negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.54041016
68relaxation of cardiac muscle (GO:0055119)3.53456116
69cell communication by electrical coupling (GO:0010644)3.46196646
70skeletal muscle adaptation (GO:0043501)3.43928590
71regulation of cardioblast differentiation (GO:0051890)3.41991911
72negative regulation of potassium ion transport (GO:0043267)3.39091542
73positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.36813399
74regulation of fatty acid oxidation (GO:0046320)3.33817245
75trabecula formation (GO:0060343)3.32929083
76regulation of sulfur metabolic process (GO:0042762)3.32498728
77carnitine transport (GO:0015879)3.30642179
78amino-acid betaine transport (GO:0015838)3.30642179
79muscle organ development (GO:0007517)3.30267925
80muscle structure development (GO:0061061)3.29401764
81muscle cell fate commitment (GO:0042693)3.29298335
82skeletal muscle contraction (GO:0003009)3.29175608
83* muscle contraction (GO:0006936)3.28502887
84regulation of heart rate (GO:0002027)3.28350127
85relaxation of muscle (GO:0090075)3.27745722
86cardiac muscle cell action potential involved in contraction (GO:0086002)3.27715342
87cardiac muscle cell action potential (GO:0086001)3.27498181
88regulation of myoblast differentiation (GO:0045661)3.25830805
89muscle hypertrophy in response to stress (GO:0003299)3.25158580
90cardiac muscle adaptation (GO:0014887)3.25158580
91cardiac muscle hypertrophy in response to stress (GO:0014898)3.25158580
92negative regulation of striated muscle cell apoptotic process (GO:0010664)3.19428606
93striated muscle cell development (GO:0055002)3.18710233
94NADH metabolic process (GO:0006734)3.10040457
95fatty acid beta-oxidation (GO:0006635)3.08600717
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08196930
97* muscle system process (GO:0003012)3.07653054
98regulation of heart contraction (GO:0008016)3.06931137
99regulation of calcium ion transmembrane transport (GO:1903169)3.06894065
100regulation of calcium ion transmembrane transporter activity (GO:1901019)3.06894065
1012-oxoglutarate metabolic process (GO:0006103)3.06274008
102ventricular cardiac muscle cell development (GO:0055015)3.06054287
103positive regulation of myoblast differentiation (GO:0045663)3.04130020
104myoblast fusion (GO:0007520)2.96400789
105regulation of muscle contraction (GO:0006937)2.95910764
106regulation of ATPase activity (GO:0043462)2.95813617
107regulation of ATP catabolic process (GO:1903289)2.95813617
108striated muscle atrophy (GO:0014891)2.95711952
109positive regulation of cation channel activity (GO:2001259)2.91272446
110respiratory electron transport chain (GO:0022904)2.91173166
111striated muscle adaptation (GO:0014888)2.91117428
112negative regulation of calcium ion transmembrane transport (GO:1903170)2.90798147
113negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.90798147
114striated muscle tissue development (GO:0014706)2.90789929
115response to inactivity (GO:0014854)2.90674802
116cardiac conduction (GO:0061337)2.90206702
117metanephric mesenchyme development (GO:0072075)2.89815692
118glycogen catabolic process (GO:0005980)2.87309239
119regulation of muscle system process (GO:0090257)2.86023573
120positive regulation of fatty acid oxidation (GO:0046321)2.83614545
121cGMP-mediated signaling (GO:0019934)2.83241193
122mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.83018948
123cell migration involved in heart development (GO:0060973)2.82166757
124negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81667855
125electron transport chain (GO:0022900)2.81515798
126muscle cell development (GO:0055001)2.80993980
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.78600026
128muscle tissue development (GO:0060537)2.76123146
129extracellular fibril organization (GO:0043206)2.74046815
130myotube differentiation (GO:0014902)2.72327940
131response to epinephrine (GO:0071871)2.68729067
132glucan catabolic process (GO:0009251)2.66962610
133kidney mesenchyme development (GO:0072074)2.66871895
134relaxation of smooth muscle (GO:0044557)2.66281535
135muscle atrophy (GO:0014889)2.65841200
136regulation of skeletal muscle fiber development (GO:0048742)2.65423476
137positive regulation of myotube differentiation (GO:0010831)2.65230269
138muscle adaptation (GO:0043500)2.64954760
139glycogen biosynthetic process (GO:0005978)2.61588603
140glucan biosynthetic process (GO:0009250)2.61588603
141skeletal muscle tissue regeneration (GO:0043403)2.57501047
142negative regulation of muscle contraction (GO:0045932)2.57397457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.53607758
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.27505581
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.22753252
4* TBX20_22328084_ChIP-Seq_HEART_Mouse3.02686615
5* TBX20_22080862_ChIP-Seq_HEART_Mouse3.02686615
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.81730961
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.73494699
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.51689950
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50169447
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43407380
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.38722167
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38680462
13* GBX2_23144817_ChIP-Seq_PC3_Human2.31079032
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.28071313
15CLOCK_20551151_ChIP-Seq_293T_Human2.25592471
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20850255
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12579641
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.05901564
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.04136979
20CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84972937
21ZNF263_19887448_ChIP-Seq_K562_Human1.82562261
22TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73822752
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.66649211
24* CJUN_26792858_Chip-Seq_BT549_Human1.62918404
25EZH2_22144423_ChIP-Seq_EOC_Human1.60173998
26* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.57293667
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57175193
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54986357
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50547614
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46459413
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.46201961
32* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46072647
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41813323
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.41543544
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41353530
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41353530
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40950515
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38000128
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36399032
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.31475969
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31251223
42ISL1_27105846_Chip-Seq_CPCs_Mouse1.29994272
43NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.29801056
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.26950010
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26623594
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24188898
47* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23502960
48* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23502960
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21603646
50VDR_22108803_ChIP-Seq_LS180_Human1.20391933
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19617937
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19313498
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19080481
54* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16527798
55TP53_18474530_ChIP-ChIP_U2OS_Human1.15926209
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15243887
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14283724
58DROSHA_22980978_ChIP-Seq_HELA_Human1.13676304
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12996929
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12092568
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10263058
62TP53_16413492_ChIP-PET_HCT116_Human1.09250053
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09069098
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08439511
65* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08269885
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07592423
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.06099052
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05681940
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05639161
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.04213137
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02412372
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.02375630
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01901348
74BCAT_22108803_ChIP-Seq_LS180_Human1.01713421
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.01361493
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01257490
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00008408
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98153294
79* BRD4_25478319_ChIP-Seq_HGPS_Human0.97819966
80* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97649911
81* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97569623
82ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97135158
83P300_19829295_ChIP-Seq_ESCs_Human0.96652607
84SOX2_21211035_ChIP-Seq_LN229_Gbm0.95400440
85AR_21572438_ChIP-Seq_LNCaP_Human0.95217177
86EED_16625203_ChIP-ChIP_MESCs_Mouse0.94361805
87AHR_22903824_ChIP-Seq_MCF-7_Human0.94250108
88EZH2_27294783_Chip-Seq_ESCs_Mouse0.93581357
89ER_23166858_ChIP-Seq_MCF-7_Human0.93428235
90* PIAS1_25552417_ChIP-Seq_VCAP_Human0.92713089
91SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92559003
92* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92286713
93CBP_20019798_ChIP-Seq_JUKART_Human0.91780953
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91780953
95FOXA2_19822575_ChIP-Seq_HepG2_Human0.91738204
96CDX2_22108803_ChIP-Seq_LS180_Human0.91469584
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.91029116
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91013490
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90994302
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.90927789
101KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90842893
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90493030
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89927845
104TCF4_18268006_ChIP-ChIP_LS174T_Human0.89227622
105LXR_22158963_ChIP-Seq_LIVER_Mouse0.88565095
106* TCF4_23295773_ChIP-Seq_U87_Human0.87638005
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87308561
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87084091
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86080776
110TBL1_22424771_ChIP-Seq_293T_Human0.86069893
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85604391
112RNF2_27304074_Chip-Seq_ESCs_Mouse0.85085881
113JARID2_20064375_ChIP-Seq_MESCs_Mouse0.84612295
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84496695
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84133743
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83952274
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83895004
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.83584948
119ZNF274_21170338_ChIP-Seq_K562_Hela0.83550305
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83260989
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82747656
122NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81844883
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80914843
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80603010
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79990654
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.79571649
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.79532626
128SMAD_19615063_ChIP-ChIP_OVARY_Human0.79506693
129* TP53_23651856_ChIP-Seq_MEFs_Mouse0.78065251
130GATA1_19941826_ChIP-Seq_K562_Human0.77034896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.86682729
2MP0004084_abnormal_cardiac_muscle5.00418133
3MP0000751_myopathy4.89822699
4MP0003646_muscle_fatigue4.82543265
5MP0004215_abnormal_myocardial_fiber4.04210829
6MP0004036_abnormal_muscle_relaxation3.95523877
7MP0000749_muscle_degeneration3.73559294
8MP0005330_cardiomyopathy3.46689847
9MP0004087_abnormal_muscle_fiber2.97175146
10MP0002972_abnormal_cardiac_muscle2.84219029
11MP0008438_abnormal_cutaneous_collagen2.82131039
12MP0004130_abnormal_muscle_cell2.80132578
13MP0000750_abnormal_muscle_regeneration2.71845021
14MP0008775_abnormal_heart_ventricle2.68021902
15MP0005620_abnormal_muscle_contractility2.66307915
16MP0004145_abnormal_muscle_electrophysio2.58603906
17MP0003137_abnormal_impulse_conducting2.48235978
18MP0002106_abnormal_muscle_physiology2.45531413
19MP0010630_abnormal_cardiac_muscle2.32886770
20MP0001544_abnormal_cardiovascular_syste2.31626384
21MP0005385_cardiovascular_system_phenoty2.31626384
22MP0004484_altered_response_of2.29918551
23MP0006138_congestive_heart_failure2.28773308
24MP0005369_muscle_phenotype2.11520896
25MP0002269_muscular_atrophy2.11198039
26MP0000747_muscle_weakness2.09788528
27MP0003950_abnormal_plasma_membrane2.08861150
28MP0003828_pulmonary_edema2.05959818
29MP0000759_abnormal_skeletal_muscle2.05651222
30MP0005275_abnormal_skin_tensile1.89923538
31MP0005666_abnormal_adipose_tissue1.85233618
32MP0004085_abnormal_heartbeat1.81382061
33MP0005670_abnormal_white_adipose1.76441713
34MP0003279_aneurysm1.73370760
35MP0004233_abnormal_muscle_weight1.66684032
36MP0005503_abnormal_tendon_morphology1.59496090
37MP0003221_abnormal_cardiomyocyte_apopto1.59300829
38MP0004185_abnormal_adipocyte_glucose1.57418350
39MP0004272_abnormal_basement_membrane1.44121311
40MP0002108_abnormal_muscle_morphology1.43322372
41MP0005375_adipose_tissue_phenotype1.39026145
42MP0010368_abnormal_lymphatic_system1.34870659
43MP0004510_myositis1.33097704
44MP0002127_abnormal_cardiovascular_syste1.32460101
45MP0002332_abnormal_exercise_endurance1.26811069
46MP0005623_abnormal_meninges_morphology1.25644227
47MP0006036_abnormal_mitochondrial_physio1.24620422
48MP0000013_abnormal_adipose_tissue1.21217812
49MP0003705_abnormal_hypodermis_morpholog1.18547862
50MP0000733_abnormal_muscle_development1.15416628
51MP0000003_abnormal_adipose_tissue1.09630041
52MP0000266_abnormal_heart_morphology1.06742300
53MP0000343_altered_response_to1.06386933
54MP0003136_yellow_coat_color1.03707374
55MP0001958_emphysema1.03072745
56MP0005165_increased_susceptibility_to1.01971143
57MP0003567_abnormal_fetal_cardiomyocyte1.01591389
58MP0009384_cardiac_valve_regurgitation0.98434943
59MP0002234_abnormal_pharynx_morphology0.95497796
60MP0003566_abnormal_cell_adhesion0.95483899
61MP0001661_extended_life_span0.92610833
62MP0000762_abnormal_tongue_morphology0.91168757
63MP0004270_analgesia0.89029134
64MP0002128_abnormal_blood_circulation0.87158430
65MP0002971_abnormal_brown_adipose0.86405004
66MP0001879_abnormal_lymphatic_vessel0.86061577
67MP0010030_abnormal_orbit_morphology0.85688583
68MP0000767_abnormal_smooth_muscle0.83191596
69MP0004134_abnormal_chest_morphology0.81153198
70MP0003879_abnormal_hair_cell0.79642786
71MP0001542_abnormal_bone_strength0.79250394
72MP0005451_abnormal_body_composition0.79052814
73MP0000230_abnormal_systemic_arterial0.78583213
74MP0002876_abnormal_thyroid_physiology0.73296226
75MP0002295_abnormal_pulmonary_circulatio0.72185749
76MP0005171_absent_coat_pigmentation0.71415481
77MP0001299_abnormal_eye_distance/0.69080105
78MP0005167_abnormal_blood-brain_barrier0.67480572
79MP0000372_irregular_coat_pigmentation0.67407101
80MP0001984_abnormal_olfaction0.67018157
81MP0010386_abnormal_urinary_bladder0.65485975
82MP0009780_abnormal_chondrocyte_physiolo0.59756523
83MP0003045_fibrosis0.58788384
84MP0000163_abnormal_cartilage_morphology0.53954601
85MP0002115_abnormal_skeleton_extremities0.53858711
86MP0008004_abnormal_stomach_pH0.53570940
87MP0006035_abnormal_mitochondrial_morpho0.53545654
88MP0005595_abnormal_vascular_smooth0.53061637
89MP0002925_abnormal_cardiovascular_devel0.52900065
90MP0001614_abnormal_blood_vessel0.52119122
91MP0005508_abnormal_skeleton_morphology0.50384523
92MP0009250_abnormal_appendicular_skeleto0.49963598
93MP0000534_abnormal_ureter_morphology0.49703042
94MP0002877_abnormal_melanocyte_morpholog0.48255669
95MP0002909_abnormal_adrenal_gland0.48096949
96MP0002249_abnormal_larynx_morphology0.47395264
97MP0005266_abnormal_metabolism0.47271078
98MP0005166_decreased_susceptibility_to0.46639856
99MP0005023_abnormal_wound_healing0.46456801
100MP0004043_abnormal_pH_regulation0.45712192
101MP0001502_abnormal_circadian_rhythm0.45482370
102MP0002896_abnormal_bone_mineralization0.44545761
103MP0009115_abnormal_fat_cell0.43934249
104MP0001270_distended_abdomen0.43779112
105MP0002114_abnormal_axial_skeleton0.43666912
106MP0002133_abnormal_respiratory_system0.43554033
107MP0005388_respiratory_system_phenotype0.43554033
108MP0002102_abnormal_ear_morphology0.43170366
109MP0005187_abnormal_penis_morphology0.43100521
110MP0002933_joint_inflammation0.40564210
111MP0003385_abnormal_body_wall0.40507930
112MP0001784_abnormal_fluid_regulation0.39411520
113MP0003091_abnormal_cell_migration0.39410402
114MP0002078_abnormal_glucose_homeostasis0.39161026
115MP0004147_increased_porphyrin_level0.36802050
116MP0003948_abnormal_gas_homeostasis0.36652866
117MP0005334_abnormal_fat_pad0.34939241
118MP0000920_abnormal_myelination0.32539765
119MP0008961_abnormal_basal_metabolism0.31708316
120MP0002060_abnormal_skin_morphology0.31309830
121MP0003935_abnormal_craniofacial_develop0.31179112
122MP0000428_abnormal_craniofacial_morphol0.31083329
123MP0005535_abnormal_body_temperature0.30536147
124MP0003690_abnormal_glial_cell0.30172711
125MP0002168_other_aberrant_phenotype0.30070650

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.98167457
2Calf muscle hypertrophy (HP:0008981)5.99009786
3Ventricular tachycardia (HP:0004756)5.83053321
4Exercise-induced myalgia (HP:0003738)5.66562534
5Muscle hypertrophy of the lower extremities (HP:0008968)5.63085476
6Muscle fiber splitting (HP:0003555)5.62728746
7Exercise-induced muscle cramps (HP:0003710)5.55628188
8Atrial fibrillation (HP:0005110)5.33170629
9Abnormality of the calf musculature (HP:0001430)5.06936576
10Primary atrial arrhythmia (HP:0001692)4.95053847
11Hyporeflexia of lower limbs (HP:0002600)4.87948693
12Lipoatrophy (HP:0100578)4.86557836
13Supraventricular tachycardia (HP:0004755)4.72660212
14Supraventricular arrhythmia (HP:0005115)4.66946422
15Myoglobinuria (HP:0002913)4.60111891
16Right ventricular cardiomyopathy (HP:0011663)4.51255420
17Subaortic stenosis (HP:0001682)4.48392122
18Abnormality of the left ventricular outflow tract (HP:0011103)4.48392122
19Increased connective tissue (HP:0009025)4.20392734
20Type 1 muscle fiber predominance (HP:0003803)4.09363653
21Syncope (HP:0001279)4.04275221
22Ulnar deviation of the wrist (HP:0003049)4.03524188
23Myopathic facies (HP:0002058)4.01959775
24EMG: myopathic abnormalities (HP:0003458)3.98612858
25Dilated cardiomyopathy (HP:0001644)3.97058924
26Difficulty running (HP:0009046)3.96229669
27Bundle branch block (HP:0011710)3.93428896
28Centrally nucleated skeletal muscle fibers (HP:0003687)3.79699252
29Prolonged QT interval (HP:0001657)3.76024196
30Asymmetric septal hypertrophy (HP:0001670)3.65872181
31Palpitations (HP:0001962)3.57158913
32Calcaneovalgus deformity (HP:0001848)3.56372360
33Ventricular arrhythmia (HP:0004308)3.53480668
34Rhabdomyolysis (HP:0003201)3.44924330
35Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.42292805
36Muscle fiber inclusion bodies (HP:0100299)3.41362485
37Myotonia (HP:0002486)3.37542459
38Heart block (HP:0012722)3.34359013
39Increased variability in muscle fiber diameter (HP:0003557)3.27694808
40Atrioventricular block (HP:0001678)3.25785164
41Aortic aneurysm (HP:0004942)3.25665982
42Absent phalangeal crease (HP:0006109)3.24733608
43Abnormal atrioventricular conduction (HP:0005150)3.22919586
44Deformed tarsal bones (HP:0008119)3.16852936
45Popliteal pterygium (HP:0009756)3.06919625
46Abnormality of skeletal muscle fiber size (HP:0012084)3.02806225
47Difficulty climbing stairs (HP:0003551)3.00922621
48Frequent falls (HP:0002359)3.00166008
49Broad metatarsal (HP:0001783)2.96638940
50Malignant hyperthermia (HP:0002047)2.95017269
51Ventricular fibrillation (HP:0001663)2.89662334
52Nemaline bodies (HP:0003798)2.84116268
53Muscle stiffness (HP:0003552)2.70710175
54Abnormal finger flexion creases (HP:0006143)2.67434494
55Weak cry (HP:0001612)2.66482595
56Aortic dissection (HP:0002647)2.58645574
57Abnormal EKG (HP:0003115)2.58178170
58Left ventricular hypertrophy (HP:0001712)2.58087690
59Neck muscle weakness (HP:0000467)2.55171655
60Fetal akinesia sequence (HP:0001989)2.53628952
61Bulbar palsy (HP:0001283)2.53547831
62Hypoplastic ischia (HP:0003175)2.52236857
63Ketoacidosis (HP:0001993)2.52176524
64Mildly elevated creatine phosphokinase (HP:0008180)2.49000707
65Hypoglycemic coma (HP:0001325)2.43375898
66Abnormality of the shoulder girdle musculature (HP:0001435)2.41046307
67Hepatic necrosis (HP:0002605)2.39891823
68Scapular winging (HP:0003691)2.38440591
69Premature rupture of membranes (HP:0001788)2.37734142
70Spinal rigidity (HP:0003306)2.32320292
71Protrusio acetabuli (HP:0003179)2.32320079
72Fatigable weakness (HP:0003473)2.31168176
73Abnormality of the neuromuscular junction (HP:0003398)2.31168176
74Gowers sign (HP:0003391)2.28652485
75Abnormality of the ischium (HP:0003174)2.26998892
76Abnormal mitochondria in muscle tissue (HP:0008316)2.26837668
77Limited hip movement (HP:0008800)2.24632655
78Acute necrotizing encephalopathy (HP:0006965)2.22701050
79Distal lower limb muscle weakness (HP:0009053)2.21605277
80Slender build (HP:0001533)2.21549216
81Round ear (HP:0100830)2.18301019
82Palmoplantar keratoderma (HP:0000982)2.13870171
83Respiratory insufficiency due to muscle weakness (HP:0002747)2.11752984
84Limb-girdle muscle atrophy (HP:0003797)2.11499457
85Ankle contracture (HP:0006466)2.10480408
86Pheochromocytoma (HP:0002666)2.07403636
87Areflexia of lower limbs (HP:0002522)2.07055339
88Muscular dystrophy (HP:0003560)2.05614956
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05100689
90Abnormality of fatty-acid metabolism (HP:0004359)2.04642475
91Generalized muscle weakness (HP:0003324)2.04625254
92Conjunctival hamartoma (HP:0100780)2.04261340
93Steppage gait (HP:0003376)2.03256160
94Distal lower limb amyotrophy (HP:0008944)1.99777099
95Facial diplegia (HP:0001349)1.97850841
96Distal arthrogryposis (HP:0005684)1.96447363
97Abnormality of the foot musculature (HP:0001436)1.96187518
98Dicarboxylic aciduria (HP:0003215)1.95610696
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95610696
100Hepatocellular necrosis (HP:0001404)1.95562617
101Hyperkalemia (HP:0002153)1.95381993
102Acute encephalopathy (HP:0006846)1.93224328
103Progressive macrocephaly (HP:0004481)1.91715783
104Nonprogressive disorder (HP:0003680)1.90993239
105Hip contracture (HP:0003273)1.90668260
106Foot dorsiflexor weakness (HP:0009027)1.89367912
107Sudden cardiac death (HP:0001645)1.87765433
108Congestive heart failure (HP:0001635)1.85258999
109Vascular tortuosity (HP:0004948)1.85235312
110Type 2 muscle fiber atrophy (HP:0003554)1.85216751
111Aplasia of the musculature (HP:0100854)1.84762716
112Increased muscle lipid content (HP:0009058)1.84218978
113Waddling gait (HP:0002515)1.83612683
114Breech presentation (HP:0001623)1.83004231
115Metatarsus adductus (HP:0001840)1.82977814
116EMG: neuropathic changes (HP:0003445)1.82875596
117Pulmonary artery stenosis (HP:0004415)1.82594524
118Large for gestational age (HP:0001520)1.81493842
119Abnormality of alanine metabolism (HP:0010916)1.80200471
120Hyperalaninemia (HP:0003348)1.80200471
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80200471
122Neuroendocrine neoplasm (HP:0100634)1.80135499
123Rimmed vacuoles (HP:0003805)1.79535779
124Abnormality of the calcaneus (HP:0008364)1.79399061
125Limb-girdle muscle weakness (HP:0003325)1.78933644
126Proximal amyotrophy (HP:0007126)1.78402771
127Testicular atrophy (HP:0000029)1.77289765
128Ketosis (HP:0001946)1.74558440
129Infantile muscular hypotonia (HP:0008947)1.72932003
130Hamartoma of the eye (HP:0010568)1.70377894
131Cerebral edema (HP:0002181)1.68415624
132Arterial tortuosity (HP:0005116)1.67189479
133Insulin-resistant diabetes mellitus (HP:0000831)1.66925761
134Cerebral aneurysm (HP:0004944)1.63293481
135Soft skin (HP:0000977)1.56821293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.38699726
2OBSCN4.20653459
3PHKG13.56997494
4PHKG23.56997494
5LMTK23.40409276
6DMPK3.07581046
7MYLK3.03351176
8TRIB33.01845202
9PDK42.97139235
10PDK32.97139235
11PKN22.65326232
12TIE12.42701489
13MUSK2.31006399
14PIK3CA2.20361280
15BCKDK2.05533781
16FRK1.86209282
17PDK21.85627835
18PINK11.80651555
19STK241.77063530
20PDGFRA1.75882069
21NEK11.51997272
22PAK31.47084048
23STK391.39237312
24TRPM71.36442217
25PRKD11.32414301
26ILK1.30739381
27LATS11.21961598
28WNK41.21871702
29EPHB11.21707176
30INSRR1.20952231
31RIPK11.13543749
32ROCK11.10197848
33GRK71.10161252
34CAMK2D1.09248681
35MAP3K71.05166540
36STK38L1.02349919
37MARK30.98018693
38LATS20.97679859
39SIK10.96105955
40MAPK120.94283649
41PRKAA20.93992671
42CCNB10.90045411
43PRKD30.88911609
44BLK0.87842841
45ROCK20.85935199
46MARK10.85612841
47SGK20.85507676
48TGFBR20.84528035
49DDR20.83966006
50WNK10.83403043
51PKN10.82787225
52PRKAA10.81819103
53CDC42BPA0.80737189
54FGFR20.80593392
55ICK0.73568895
56CAMK1D0.72566240
57ZAK0.71300396
58MAPKAPK30.71259884
59SGK4940.68282529
60SGK2230.68282529
61NLK0.68064634
62NEK90.67419989
63RET0.62927326
64FLT30.62451641
65MET0.61310555
66PDGFRB0.61108025
67SGK30.60766766
68EPHB20.59731177
69ERBB30.58585164
70KSR20.58005765
71MAP3K90.57881058
72EPHA30.57660029
73CAMK2B0.56975168
74CAMK1G0.56464757
75PTK2B0.56378578
76CAMK2A0.56230427
77STK380.53379970
78PIK3CG0.53371369
79FER0.52491880
80PAK60.52126442
81CAMK40.50894157
82MOS0.50435921
83PRKCH0.50406706
84FGFR40.50361023
85PRKCE0.49519544
86PDPK10.48941047
87MELK0.48640567
88AKT30.46131538
89PRKG20.45331986
90PRKACB0.43688558
91BMPR1B0.43342926
92DAPK30.43338296
93MAP3K130.42568148
94MAP3K50.41774674
95STK40.40887710
96MAP3K10.39641080
97PRKD20.39599074
98PTK60.39098979
99LIMK10.39089796
100LRRK20.38546404
101CAMK2G0.38416542
102MAPK150.38378297
103MAPK40.38351700
104FGFR30.37331434
105KIT0.36863366
106CAMK10.36859927
107ADRBK10.34640417
108GSK3A0.32978269
109PTK20.32897800
110MTOR0.32826806
111MAP2K40.32788785
112PRKACA0.32787155
113PDK10.31631863
114MAP2K10.30827249
115PRKACG0.29754888
116PAK20.29023855
117GRK50.28928619
118FGFR10.27988593
119AKT20.27020698
120RPS6KB10.26646760
121MAP2K30.25920619
122RPS6KA30.24176351
123MAP3K60.24098606
124TGFBR10.23621196
125JAK10.23316892
126MAPK70.23259744
127STK30.22789531
128MAPKAPK50.21517557
129MARK20.20105999
130EEF2K0.20104294
131PRKG10.19453190

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.29648420
2Dilated cardiomyopathy_Homo sapiens_hsa054143.67856204
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.59003109
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.58834763
5Cardiac muscle contraction_Homo sapiens_hsa042603.52013031
6Propanoate metabolism_Homo sapiens_hsa006403.43385290
7Fatty acid degradation_Homo sapiens_hsa000712.89087495
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68415390
9Fatty acid metabolism_Homo sapiens_hsa012122.49591122
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47309710
11Parkinsons disease_Homo sapiens_hsa050122.27277314
12Oxidative phosphorylation_Homo sapiens_hsa001902.08954867
13Carbon metabolism_Homo sapiens_hsa012002.01931224
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80238763
15Alzheimers disease_Homo sapiens_hsa050101.76271823
16Fatty acid elongation_Homo sapiens_hsa000621.74341824
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68042485
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67881241
19Pyruvate metabolism_Homo sapiens_hsa006201.67424595
20Viral myocarditis_Homo sapiens_hsa054161.51829033
21PPAR signaling pathway_Homo sapiens_hsa033201.45611464
22ECM-receptor interaction_Homo sapiens_hsa045121.45251225
23Butanoate metabolism_Homo sapiens_hsa006501.41744881
24Focal adhesion_Homo sapiens_hsa045101.36917331
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35845964
26Nitrogen metabolism_Homo sapiens_hsa009101.35607105
27Huntingtons disease_Homo sapiens_hsa050161.32368777
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.31090227
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28992747
30Insulin resistance_Homo sapiens_hsa049311.23347483
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.16717552
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16331174
33Fatty acid biosynthesis_Homo sapiens_hsa000611.15560722
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14501616
35Insulin signaling pathway_Homo sapiens_hsa049101.03265607
36Histidine metabolism_Homo sapiens_hsa003401.01638787
37AMPK signaling pathway_Homo sapiens_hsa041521.00804171
38Glucagon signaling pathway_Homo sapiens_hsa049221.00338248
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89612440
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.88577338
41Tight junction_Homo sapiens_hsa045300.87801083
42Starch and sucrose metabolism_Homo sapiens_hsa005000.87355683
43Regulation of autophagy_Homo sapiens_hsa041400.84350023
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82206721
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81320713
46Calcium signaling pathway_Homo sapiens_hsa040200.77020790
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77006181
48Lysine degradation_Homo sapiens_hsa003100.75990640
49beta-Alanine metabolism_Homo sapiens_hsa004100.75782061
50Oxytocin signaling pathway_Homo sapiens_hsa049210.75497541
51Ovarian steroidogenesis_Homo sapiens_hsa049130.75018159
52Adherens junction_Homo sapiens_hsa045200.73323985
53Olfactory transduction_Homo sapiens_hsa047400.72473136
54Pancreatic secretion_Homo sapiens_hsa049720.71202251
55Long-term potentiation_Homo sapiens_hsa047200.69046593
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68158487
57Mineral absorption_Homo sapiens_hsa049780.66899096
58Biosynthesis of amino acids_Homo sapiens_hsa012300.65884522
59Renin secretion_Homo sapiens_hsa049240.63995790
60Amoebiasis_Homo sapiens_hsa051460.63957782
61Type II diabetes mellitus_Homo sapiens_hsa049300.63162630
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63016239
63HIF-1 signaling pathway_Homo sapiens_hsa040660.62914505
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61734966
65Tryptophan metabolism_Homo sapiens_hsa003800.61662682
66Proteoglycans in cancer_Homo sapiens_hsa052050.59208847
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58901753
68Renal cell carcinoma_Homo sapiens_hsa052110.58164204
69Amphetamine addiction_Homo sapiens_hsa050310.57961262
70Hedgehog signaling pathway_Homo sapiens_hsa043400.57371967
71cAMP signaling pathway_Homo sapiens_hsa040240.57244041
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57211475
73MAPK signaling pathway_Homo sapiens_hsa040100.55345731
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55248980
75Arginine and proline metabolism_Homo sapiens_hsa003300.53778336
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.53655459
77Gastric acid secretion_Homo sapiens_hsa049710.52458510
78Protein digestion and absorption_Homo sapiens_hsa049740.52167252
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51112789
80GABAergic synapse_Homo sapiens_hsa047270.50668092
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50507692
82Circadian rhythm_Homo sapiens_hsa047100.48624867
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48029907
84Bile secretion_Homo sapiens_hsa049760.47125917
85Thyroid hormone synthesis_Homo sapiens_hsa049180.46132841
86Peroxisome_Homo sapiens_hsa041460.45427416
87Dorso-ventral axis formation_Homo sapiens_hsa043200.44104690
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41459686
89ABC transporters_Homo sapiens_hsa020100.40728892
90GnRH signaling pathway_Homo sapiens_hsa049120.40082208
91Long-term depression_Homo sapiens_hsa047300.40031632
92Phototransduction_Homo sapiens_hsa047440.39700464
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39697958
94Glioma_Homo sapiens_hsa052140.39259440
95Dopaminergic synapse_Homo sapiens_hsa047280.39156979
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38391479
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36568806
98Pentose phosphate pathway_Homo sapiens_hsa000300.36175668
99Fructose and mannose metabolism_Homo sapiens_hsa000510.35358974
100Insulin secretion_Homo sapiens_hsa049110.35328432
101Wnt signaling pathway_Homo sapiens_hsa043100.34619307
102Small cell lung cancer_Homo sapiens_hsa052220.34511912
103Platelet activation_Homo sapiens_hsa046110.34000383
104Glutamatergic synapse_Homo sapiens_hsa047240.32498104
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.32491433
106Glycerolipid metabolism_Homo sapiens_hsa005610.31075036
107Circadian entrainment_Homo sapiens_hsa047130.30328702
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30318326
109Gap junction_Homo sapiens_hsa045400.30020822
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.26938583
111Melanogenesis_Homo sapiens_hsa049160.25508321
112Phenylalanine metabolism_Homo sapiens_hsa003600.25038912
113Arginine biosynthesis_Homo sapiens_hsa002200.24915253
114Tyrosine metabolism_Homo sapiens_hsa003500.24491884
115Cholinergic synapse_Homo sapiens_hsa047250.23822974
116mTOR signaling pathway_Homo sapiens_hsa041500.23623479
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23031674
118Melanoma_Homo sapiens_hsa052180.22941704
119VEGF signaling pathway_Homo sapiens_hsa043700.22738406
120FoxO signaling pathway_Homo sapiens_hsa040680.21950484
121Rap1 signaling pathway_Homo sapiens_hsa040150.20627905
122TGF-beta signaling pathway_Homo sapiens_hsa043500.19662495
123Galactose metabolism_Homo sapiens_hsa000520.19644357
124Hippo signaling pathway_Homo sapiens_hsa043900.19637444
125Axon guidance_Homo sapiens_hsa043600.18638021
126Sulfur metabolism_Homo sapiens_hsa009200.18415607
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17837048
128Ras signaling pathway_Homo sapiens_hsa040140.17661789
129Estrogen signaling pathway_Homo sapiens_hsa049150.17291616
130Pathways in cancer_Homo sapiens_hsa052000.16930375
131Salivary secretion_Homo sapiens_hsa049700.15332745

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