SSR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)7.00988632
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.33327808
3Golgi transport vesicle coating (GO:0048200)6.23028281
4COPI coating of Golgi vesicle (GO:0048205)6.23028281
5protein retention in ER lumen (GO:0006621)5.91902706
6response to pheromone (GO:0019236)5.54281664
7keratan sulfate catabolic process (GO:0042340)5.19121213
8negative regulation of phagocytosis (GO:0050765)5.03212237
9lactate metabolic process (GO:0006089)4.91080288
10cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.84844945
11chondrocyte development (GO:0002063)4.84393947
12cartilage condensation (GO:0001502)4.69899506
13cell aggregation (GO:0098743)4.69899506
14nucleotide-sugar biosynthetic process (GO:0009226)4.01675537
15negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.98576474
16ER overload response (GO:0006983)3.97466991
17positive regulation of protein autophosphorylation (GO:0031954)3.90723865
18cellular ketone body metabolic process (GO:0046950)3.90717199
19respiratory chain complex IV assembly (GO:0008535)3.86428635
20cullin deneddylation (GO:0010388)3.81561556
21ketone body metabolic process (GO:1902224)3.76874405
22notochord development (GO:0030903)3.71366531
23water-soluble vitamin biosynthetic process (GO:0042364)3.69152145
24positive regulation of glycolytic process (GO:0045821)3.63268069
25zinc ion transport (GO:0006829)3.62674367
26COPII vesicle coating (GO:0048208)3.54190797
27proteasome assembly (GO:0043248)3.51970084
28protein deneddylation (GO:0000338)3.47504364
29negative regulation of mast cell activation (GO:0033004)3.43654975
30collagen fibril organization (GO:0030199)3.40379610
31inositol phosphate catabolic process (GO:0071545)3.36279625
32poly(A)+ mRNA export from nucleus (GO:0016973)3.35041070
33regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.30458992
34negative regulation of complement activation (GO:0045916)3.30011698
35negative regulation of protein activation cascade (GO:2000258)3.28257032
36cytochrome complex assembly (GO:0017004)3.26050068
37regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.22959650
38chondroitin sulfate biosynthetic process (GO:0030206)3.22489573
39positive regulation of actin filament depolymerization (GO:0030836)3.22427736
40positive regulation of extracellular matrix organization (GO:1903055)3.20733992
41polyol catabolic process (GO:0046174)3.18431544
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.17769528
43DNA ligation (GO:0006266)3.16429626
44lipopolysaccharide biosynthetic process (GO:0009103)3.16196309
45meiotic chromosome segregation (GO:0045132)3.12005987
46ER to Golgi vesicle-mediated transport (GO:0006888)3.11310357
47branched-chain amino acid catabolic process (GO:0009083)3.10913078
48negative regulation of neurological system process (GO:0031645)3.10516461
49regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.06474408
50limb bud formation (GO:0060174)3.05981316
51ribosome assembly (GO:0042255)3.05767991
52IMP biosynthetic process (GO:0006188)3.05620693
53nucleotide-sugar metabolic process (GO:0009225)3.04170655
54keratinocyte development (GO:0003334)3.03762390
55mannosylation (GO:0097502)3.03252059
56phosphorylated carbohydrate dephosphorylation (GO:0046838)3.03197585
57inositol phosphate dephosphorylation (GO:0046855)3.03197585
58type B pancreatic cell development (GO:0003323)3.02811030
59nucleotide transmembrane transport (GO:1901679)3.02388308
60prenylation (GO:0097354)3.00201987
61protein prenylation (GO:0018342)3.00201987
62embryonic skeletal joint morphogenesis (GO:0060272)2.99884411
63RNA-dependent DNA replication (GO:0006278)2.99534119
64neutrophil mediated immunity (GO:0002446)2.96927548
65UDP-N-acetylglucosamine metabolic process (GO:0006047)2.96589554
66C-terminal protein lipidation (GO:0006501)2.95399807
67viral mRNA export from host cell nucleus (GO:0046784)2.94513627
68negative regulation of glycogen biosynthetic process (GO:0045719)2.93325501
69protein K11-linked deubiquitination (GO:0035871)2.93181464
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.93180043
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93180043
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93180043
73nucleobase biosynthetic process (GO:0046112)2.92121463
74dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.91007874
75pteridine-containing compound biosynthetic process (GO:0042559)2.89683969
76deoxyribonucleotide biosynthetic process (GO:0009263)2.86675001
77positive regulation of histone H3-K4 methylation (GO:0051571)2.86360925
78heart process (GO:0003015)2.85659340
79heart contraction (GO:0060047)2.85659340
80inositol phosphate-mediated signaling (GO:0048016)2.85648720
81neutrophil activation involved in immune response (GO:0002283)2.85322416
82telomere maintenance via semi-conservative replication (GO:0032201)2.85080042
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82282220
84regulation of acyl-CoA biosynthetic process (GO:0050812)2.82225518
85peptide catabolic process (GO:0043171)2.82178759
86chaperone-mediated protein folding (GO:0061077)2.80793020
87regulation of growth of symbiont in host (GO:0044126)2.80628609
88negative regulation of growth of symbiont in host (GO:0044130)2.80628609
89negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.80628609
90modulation of growth of symbiont involved in interaction with host (GO:0044144)2.80628609
91nucleobase-containing small molecule interconversion (GO:0015949)2.79502536
922-deoxyribonucleotide biosynthetic process (GO:0009265)2.78044827
93deoxyribose phosphate biosynthetic process (GO:0046385)2.78044827
94telomere maintenance via recombination (GO:0000722)2.76674758
95platelet dense granule organization (GO:0060155)2.75992589
96rRNA methylation (GO:0031167)2.75552523
97regulation of metalloenzyme activity (GO:0048552)2.73767323
98purine nucleobase biosynthetic process (GO:0009113)2.73112988
99negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.73026103
100magnesium ion transport (GO:0015693)2.72123999
101zinc ion transmembrane transport (GO:0071577)2.71900717
102insulin secretion (GO:0030073)2.71519439
103negative regulation of execution phase of apoptosis (GO:1900118)2.71451745
104CENP-A containing nucleosome assembly (GO:0034080)2.71312365
105synapsis (GO:0007129)2.71209201
106regulation of male gonad development (GO:2000018)2.70913977
107intra-Golgi vesicle-mediated transport (GO:0006891)2.70873924
108lipopolysaccharide metabolic process (GO:0008653)2.69792332
109regulation of protein autophosphorylation (GO:0031952)2.68692533
110xenobiotic catabolic process (GO:0042178)2.67777806
111protein peptidyl-prolyl isomerization (GO:0000413)2.67605219
112myeloid leukocyte mediated immunity (GO:0002444)2.66648044
113DNA strand renaturation (GO:0000733)2.66184916
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65654363
115DNA double-strand break processing (GO:0000729)2.65290605
116glycosphingolipid catabolic process (GO:0046479)2.62887400
117mitotic recombination (GO:0006312)2.62235671
118peptidyl-cysteine modification (GO:0018198)2.61320277
119histamine secretion (GO:0001821)2.60267299
120DNA topological change (GO:0006265)2.59372212
121positive regulation of male gonad development (GO:2000020)2.59223531
122preassembly of GPI anchor in ER membrane (GO:0016254)2.57973533
123replication fork processing (GO:0031297)2.55968966
124C-terminal protein amino acid modification (GO:0018410)2.55881618
125production of molecular mediator involved in inflammatory response (GO:0002532)2.54224892
126negative regulation of chemokine production (GO:0032682)2.53170342
127chromatin remodeling at centromere (GO:0031055)2.53134413
128myelin assembly (GO:0032288)2.53099540
129regulation of coenzyme metabolic process (GO:0051196)2.52092614
130regulation of cofactor metabolic process (GO:0051193)2.52092614
131regulation of sulfur metabolic process (GO:0042762)2.51315091
132regulation of protein glycosylation (GO:0060049)2.51157415
133regulation of type B pancreatic cell apoptotic process (GO:2000674)2.49364498
134protein N-linked glycosylation (GO:0006487)2.48320316
135maturation of 5.8S rRNA (GO:0000460)2.48092036
136energy homeostasis (GO:0097009)2.47879174
137endosome to pigment granule transport (GO:0043485)2.47507307
138endosome to melanosome transport (GO:0035646)2.47507307
139reactive oxygen species biosynthetic process (GO:1903409)2.47481532
140regulation of glucokinase activity (GO:0033131)2.46996963
141regulation of hexokinase activity (GO:1903299)2.46996963
142nucleotide-excision repair, DNA gap filling (GO:0006297)2.46664928
143folic acid-containing compound biosynthetic process (GO:0009396)2.46568304
144protein N-linked glycosylation via asparagine (GO:0018279)2.46116615
145cellular response to BMP stimulus (GO:0071773)2.45625247
146response to BMP (GO:0071772)2.45625247
147peptidyl-histidine modification (GO:0018202)2.44438465
148negative regulation of glycogen metabolic process (GO:0070874)2.41822642
149aldehyde catabolic process (GO:0046185)2.41726573
150cartilage development (GO:0051216)2.40840014
151glycolipid catabolic process (GO:0019377)2.39853599
152endocrine pancreas development (GO:0031018)2.39809177
153IMP metabolic process (GO:0046040)2.39433462
154DNA catabolic process, exonucleolytic (GO:0000738)2.38976271
155proteoglycan metabolic process (GO:0006029)2.38873870
156tetrahydrofolate metabolic process (GO:0046653)2.38729327
157peptidyl-asparagine modification (GO:0018196)2.38625632
158peptidyl-proline modification (GO:0018208)2.38450637
159somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.38319159
160somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.38319159
161isotype switching (GO:0045190)2.38319159
162snRNA processing (GO:0016180)2.38237607
163dendritic cell chemotaxis (GO:0002407)2.38063097
164sequestering of metal ion (GO:0051238)2.37919001
165regulation of cellular amino acid metabolic process (GO:0006521)2.37533591
166negative regulation of hormone biosynthetic process (GO:0032353)2.37237117
167definitive hemopoiesis (GO:0060216)2.36665810
168negative regulation of acute inflammatory response (GO:0002674)2.36538220
169regulation of cell maturation (GO:1903429)2.36346682
170antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.36124478
171sphingomyelin metabolic process (GO:0006684)2.35221899
172rRNA modification (GO:0000154)2.34555647
173vascular smooth muscle contraction (GO:0014829)2.33621103
174peptide hormone processing (GO:0016486)2.32995389
175S-adenosylmethionine metabolic process (GO:0046500)2.32724892
176L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.32039453
177cellular zinc ion homeostasis (GO:0006882)2.30860071
178iron ion import (GO:0097286)2.30760881
179cell wall macromolecule catabolic process (GO:0016998)2.29811950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.82436816
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91080689
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.15014871
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06266408
5GATA1_22025678_ChIP-Seq_K562_Human2.95917637
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.78860855
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.61655289
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.56535573
9ELK1_19687146_ChIP-ChIP_HELA_Human2.55963407
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51935461
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.46668523
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.41949961
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38721471
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28430899
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.23364466
16ZNF274_21170338_ChIP-Seq_K562_Hela2.21264087
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.18240126
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17614825
19FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.12370884
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.09964057
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.09658939
22HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99746955
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96220955
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91820154
25FUS_26573619_Chip-Seq_HEK293_Human1.85332386
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.84916063
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79155337
28VDR_23849224_ChIP-Seq_CD4+_Human1.78154295
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.77433256
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73632761
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72923472
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72062203
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71278131
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70254922
35IGF1R_20145208_ChIP-Seq_DFB_Human1.68434062
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67537260
37P300_19829295_ChIP-Seq_ESCs_Human1.64111665
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63818794
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.63400691
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62363004
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59407780
42GBX2_23144817_ChIP-Seq_PC3_Human1.59118446
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.59018602
44* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58840420
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.54604426
46* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54004416
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51857446
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.49462944
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49000193
50* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48579953
51* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48417103
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47998308
53TAF15_26573619_Chip-Seq_HEK293_Human1.47282157
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46428036
55ER_23166858_ChIP-Seq_MCF-7_Human1.43070885
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42324104
57EWS_26573619_Chip-Seq_HEK293_Human1.40152123
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.39955287
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39463981
60CDX2_22108803_ChIP-Seq_LS180_Human1.39159088
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38216374
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37877124
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36676328
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35905498
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35082050
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35017820
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33620753
68VDR_22108803_ChIP-Seq_LS180_Human1.33121468
69FOXP3_21729870_ChIP-Seq_TREG_Human1.32006435
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31584704
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.31373429
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29924123
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29579025
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.29478758
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.29431620
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28197094
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.27138200
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26351989
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25786983
80SMAD4_21799915_ChIP-Seq_A2780_Human1.25634607
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23686910
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22706909
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22288641
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22016724
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21411950
86CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21221462
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20476181
88BCAT_22108803_ChIP-Seq_LS180_Human1.19657914
89BP1_19119308_ChIP-ChIP_Hs578T_Human1.18372586
90EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17722109
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16875239
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.16413503
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16407019
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15922878
95STAT3_23295773_ChIP-Seq_U87_Human1.15491662
96P53_22387025_ChIP-Seq_ESCs_Mouse1.15335930
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.15210475
98NANOG_19829295_ChIP-Seq_ESCs_Human1.15025920
99SOX2_19829295_ChIP-Seq_ESCs_Human1.15025920
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13497072
101TCF4_22108803_ChIP-Seq_LS180_Human1.12842496
102AR_25329375_ChIP-Seq_VCAP_Human1.12112738
103DCP1A_22483619_ChIP-Seq_HELA_Human1.11669559
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11442138
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11334334
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10645455
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10645455
108CBP_20019798_ChIP-Seq_JUKART_Human1.10610298
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10610298
110SPI1_23547873_ChIP-Seq_NB4_Human1.09725921
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09470175
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09198331
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08935926
114HTT_18923047_ChIP-ChIP_STHdh_Human1.08770805
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08725644
116AR_21909140_ChIP-Seq_LNCAP_Human1.08381230
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.08121600
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.07991811
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07937066
120* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07546353
121* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07483984
122PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07076982
123NOTCH1_21737748_ChIP-Seq_TLL_Human1.07037777
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.06784123
125SALL4_22934838_ChIP-ChIP_CD34+_Human1.06530160
126THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05469178
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05274721
128NMYC_18555785_Chip-Seq_ESCs_Mouse1.04007609
129SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02868550
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01806352
131STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01510592
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.00974272
133CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99171320
134SOX2_18555785_Chip-Seq_ESCs_Mouse0.99140205
135P300_18555785_Chip-Seq_ESCs_Mouse0.99089237
136GABP_19822575_ChIP-Seq_HepG2_Human0.98624370
137SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96256185
138EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95691183
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95424451
140BRD4_25478319_ChIP-Seq_HGPS_Human0.95250396
141SCL_19346495_ChIP-Seq_HPC-7_Human0.94928274
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93497558
143ZFX_18555785_Chip-Seq_ESCs_Mouse0.90797374
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.90520387
145CMYC_18555785_Chip-Seq_ESCs_Mouse0.90151227
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90142073
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90080064
148* CJUN_26792858_Chip-Seq_BT549_Human0.88555112
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87110942
150* TFEB_21752829_ChIP-Seq_HELA_Human0.86953005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.75811910
2MP0005503_abnormal_tendon_morphology3.65453850
3MP0006054_spinal_hemorrhage3.52271557
4MP0004134_abnormal_chest_morphology3.31046665
5MP0002877_abnormal_melanocyte_morpholog3.14289485
6MP0002933_joint_inflammation3.04382055
7MP0010234_abnormal_vibrissa_follicle2.86233611
8MP0002282_abnormal_trachea_morphology2.69220437
9MP0000569_abnormal_digit_pigmentation2.66343686
10MP0009697_abnormal_copulation2.64145014
11MP0008057_abnormal_DNA_replication2.57309714
12MP0003123_paternal_imprinting2.55081455
13MP0004782_abnormal_surfactant_physiolog2.32930849
14MP0008007_abnormal_cellular_replicative2.27890248
15MP0002009_preneoplasia2.22212729
16MP0000163_abnormal_cartilage_morphology2.21671584
17MP0002163_abnormal_gland_morphology2.18134684
18MP0009250_abnormal_appendicular_skeleto2.15582532
19MP0002396_abnormal_hematopoietic_system2.15432295
20MP0002837_dystrophic_cardiac_calcinosis2.11149137
21MP0005646_abnormal_pituitary_gland2.03574018
22MP0008438_abnormal_cutaneous_collagen1.99397363
23MP0001542_abnormal_bone_strength1.98518316
24MP0005075_abnormal_melanosome_morpholog1.94637026
25MP0002876_abnormal_thyroid_physiology1.93129958
26MP0005379_endocrine/exocrine_gland_phen1.92253379
27MP0010094_abnormal_chromosome_stability1.91516694
28MP0002115_abnormal_skeleton_extremities1.86652721
29MP0006072_abnormal_retinal_apoptosis1.86594921
30MP0003786_premature_aging1.83196909
31MP0003693_abnormal_embryo_hatching1.81722013
32MP0001533_abnormal_skeleton_physiology1.80819029
33MP0000013_abnormal_adipose_tissue1.79567244
34MP0009780_abnormal_chondrocyte_physiolo1.78260507
35MP0005390_skeleton_phenotype1.77481008
36MP0008058_abnormal_DNA_repair1.76304096
37MP0003183_abnormal_peptide_metabolism1.76124295
38MP0002090_abnormal_vision1.75045450
39MP0002113_abnormal_skeleton_development1.70133396
40MP0002909_abnormal_adrenal_gland1.68446043
41MP0002139_abnormal_hepatobiliary_system1.67756272
42MP0003436_decreased_susceptibility_to1.67108374
43MP0010352_gastrointestinal_tract_polyps1.66095180
44MP0002938_white_spotting1.61513253
45MP0005332_abnormal_amino_acid1.60667784
46MP0001177_atelectasis1.60361573
47MP0003279_aneurysm1.60301145
48MP0003787_abnormal_imprinting1.60136016
49MP0005174_abnormal_tail_pigmentation1.59442818
50MP0003950_abnormal_plasma_membrane1.56772691
51MP0005508_abnormal_skeleton_morphology1.55880833
52MP0000427_abnormal_hair_cycle1.55274428
53MP0001835_abnormal_antigen_presentation1.54596729
54MP0003806_abnormal_nucleotide_metabolis1.54096646
55MP0004147_increased_porphyrin_level1.52970800
56MP0010329_abnormal_lipoprotein_level1.50970584
57MP0003252_abnormal_bile_duct1.50012122
58MP0001188_hyperpigmentation1.48427449
59MP0003795_abnormal_bone_structure1.48142159
60MP0001944_abnormal_pancreas_morphology1.46924315
61MP0002693_abnormal_pancreas_physiology1.43530665
62MP0003943_abnormal_hepatobiliary_system1.39497186
63MP0003718_maternal_effect1.38519145
64MP0002109_abnormal_limb_morphology1.34811068
65MP0003121_genomic_imprinting1.32335796
66MP0005253_abnormal_eye_physiology1.32037977
67MP0005365_abnormal_bile_salt1.31785855
68MP0003172_abnormal_lysosome_physiology1.30594023
69MP0002089_abnormal_postnatal_growth/wei1.30513616
70MP0005171_absent_coat_pigmentation1.29242763
71MP0002896_abnormal_bone_mineralization1.28544449
72MP0001270_distended_abdomen1.27499023
73MP0010678_abnormal_skin_adnexa1.26678797
74MP0002102_abnormal_ear_morphology1.26143576
75MP0000371_diluted_coat_color1.25962501
76MP0000372_irregular_coat_pigmentation1.22245835
77MP0002419_abnormal_innate_immunity1.22187876
78MP0002254_reproductive_system_inflammat1.19932165
79MP0005636_abnormal_mineral_homeostasis1.18090669
80MP0000015_abnormal_ear_pigmentation1.17916494
81MP0003868_abnormal_feces_composition1.17843283
82MP0005551_abnormal_eye_electrophysiolog1.17366121
83MP0001661_extended_life_span1.16374269
84MP0001756_abnormal_urination1.16299985
85MP0003186_abnormal_redox_activity1.15126034
86MP0001986_abnormal_taste_sensitivity1.14014563
87MP0002148_abnormal_hypersensitivity_rea1.13898612
88MP0005395_other_phenotype1.11005590
89MP0010386_abnormal_urinary_bladder1.10324683
90MP0008775_abnormal_heart_ventricle1.08143962
91MP0003724_increased_susceptibility_to1.08013682
92MP0001764_abnormal_homeostasis1.07067945
93MP0003077_abnormal_cell_cycle1.05497350
94MP0002295_abnormal_pulmonary_circulatio1.05157141
95MP0003890_abnormal_embryonic-extraembry1.02111852
96MP0004215_abnormal_myocardial_fiber1.00807841
97MP0000566_synostosis1.00088182
98MP0001666_abnormal_nutrient_absorption0.99956306
99MP0004957_abnormal_blastocyst_morpholog0.99867519
100MP0002168_other_aberrant_phenotype0.99762335
101MP0003111_abnormal_nucleus_morphology0.99452891
102MP0000343_altered_response_to0.99083612
103MP0005085_abnormal_gallbladder_physiolo0.98344435
104MP0000762_abnormal_tongue_morphology0.98199152
105MP0000681_abnormal_thyroid_gland0.98082019
106MP0005164_abnormal_response_to0.97306829
107MP0008877_abnormal_DNA_methylation0.97023200
108MP0002166_altered_tumor_susceptibility0.96841168
109MP0002006_tumorigenesis0.96369998
110MP0003755_abnormal_palate_morphology0.93998609
111MP0005275_abnormal_skin_tensile0.93790736
112MP0000639_abnormal_adrenal_gland0.93715059
113MP0001119_abnormal_female_reproductive0.93459018
114MP0000647_abnormal_sebaceous_gland0.92812864
115MP0003122_maternal_imprinting0.92751250
116MP0000678_abnormal_parathyroid_gland0.92725269
117MP0000538_abnormal_urinary_bladder0.92583272
118MP0002078_abnormal_glucose_homeostasis0.92257926
119MP0001958_emphysema0.92000854
120MP0001299_abnormal_eye_distance/0.91316439
121MP0009046_muscle_twitch0.90991749
122MP0002998_abnormal_bone_remodeling0.90212007
123MP0004808_abnormal_hematopoietic_stem0.90029010
124MP0005084_abnormal_gallbladder_morpholo0.89939641
125MP0009785_altered_susceptibility_to0.88381394
126MP0002160_abnormal_reproductive_system0.88131022
127MP0004019_abnormal_vitamin_homeostasis0.87159065
128MP0005367_renal/urinary_system_phenotyp0.86408422
129MP0000516_abnormal_urinary_system0.86408422
130MP0001324_abnormal_eye_pigmentation0.86300043
131MP0000049_abnormal_middle_ear0.85993934
132MP0005408_hypopigmentation0.84721898
133MP0009053_abnormal_anal_canal0.83626443
134MP0004272_abnormal_basement_membrane0.82538794
135MP0002060_abnormal_skin_morphology0.82338893
136MP0001984_abnormal_olfaction0.82100156
137MP0001879_abnormal_lymphatic_vessel0.81689862
138MP0001186_pigmentation_phenotype0.81616680
139MP0005389_reproductive_system_phenotype0.80794376
140MP0000465_gastrointestinal_hemorrhage0.79888151
141MP0002095_abnormal_skin_pigmentation0.79106757
142MP0003656_abnormal_erythrocyte_physiolo0.77673760
143MP0004264_abnormal_extraembryonic_tissu0.76946706
144MP0005645_abnormal_hypothalamus_physiol0.76840783
145MP0008004_abnormal_stomach_pH0.76083635
146MP0001243_abnormal_dermal_layer0.75891713
147MP0003763_abnormal_thymus_physiology0.74692522
148MP0006292_abnormal_olfactory_placode0.73270081
149MP0005165_increased_susceptibility_to0.73235610
150MP0006036_abnormal_mitochondrial_physio0.73235202
151MP0000858_altered_metastatic_potential0.73230091
152MP0002751_abnormal_autonomic_nervous0.71901305
153MP0002116_abnormal_craniofacial_bone0.71679637
154MP0005220_abnormal_exocrine_pancreas0.71470548
155MP0004484_altered_response_of0.71409622
156MP0003011_delayed_dark_adaptation0.68357420
157MP0005410_abnormal_fertilization0.67413681
158MP0005360_urolithiasis0.67128765
159MP0002118_abnormal_lipid_homeostasis0.66850504

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)8.05644571
2Epiphyseal dysplasia (HP:0002656)7.74213432
3Vitreoretinal degeneration (HP:0000655)6.60807052
4Flat capital femoral epiphysis (HP:0003370)5.06585581
5Cupped ribs (HP:0000887)5.03896672
6Abnormal tarsal ossification (HP:0008369)4.97621967
7Small epiphyses (HP:0010585)4.83332336
8Abnormal foot bone ossification (HP:0010675)4.71156866
9Hypoplastic ischia (HP:0003175)4.60932718
10Hypoglycemic seizures (HP:0002173)4.46307524
11Hypoglycemic coma (HP:0001325)4.35190103
12Abnormality of the ischium (HP:0003174)4.35015012
13Hypothermia (HP:0002045)4.03416388
14Delayed epiphyseal ossification (HP:0002663)3.98906953
15Absent epiphyses (HP:0010577)3.89596644
16Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.89596644
17Abnormality of femoral epiphyses (HP:0006499)3.86249116
18Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.86249116
19Metaphyseal dysplasia (HP:0100255)3.84592100
20Arthropathy (HP:0003040)3.82205829
21Genu varum (HP:0002970)3.80443071
22Hyperinsulinemic hypoglycemia (HP:0000825)3.75799853
23Ketoacidosis (HP:0001993)3.70084791
24Flat acetabular roof (HP:0003180)3.67461774
25Mild short stature (HP:0003502)3.66792737
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.62421153
27Metaphyseal cupping (HP:0003021)3.61572139
28Long clavicles (HP:0000890)3.54256113
29Abnormality of the epiphysis of the femoral head (HP:0010574)3.48040152
30Abnormality of incisor morphology (HP:0011063)3.40620384
31Abnormality of the femoral head (HP:0003368)3.39373876
32Flattened epiphyses (HP:0003071)3.37990831
33Neonatal short-limb short stature (HP:0008921)3.37077683
34Symptomatic seizures (HP:0011145)3.34015251
35Abnormality of the vertebral endplates (HP:0005106)3.29981128
36Metaphyseal irregularity (HP:0003025)3.27137180
37Short femoral neck (HP:0100864)3.24655109
38Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.16315150
39Absent frontal sinuses (HP:0002688)3.15491544
40Hyperglycemia (HP:0003074)3.13639296
41Large for gestational age (HP:0001520)3.13281143
42Stillbirth (HP:0003826)3.12366772
43Cervical subluxation (HP:0003308)3.12103192
44Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.07072212
45Hypobetalipoproteinemia (HP:0003563)3.07028380
46Pancreatic islet-cell hyperplasia (HP:0004510)3.03354235
47Methylmalonic acidemia (HP:0002912)3.02995330
4811 pairs of ribs (HP:0000878)3.01941165
49Abnormality of vitamin B metabolism (HP:0004340)2.98848043
50Beaking of vertebral bodies (HP:0004568)2.96191943
51Abnormality of endocrine pancreas physiology (HP:0012093)2.92996326
52Abnormality of the pancreatic islet cells (HP:0006476)2.92996326
53Irregular vertebral endplates (HP:0003301)2.91572986
54Osteoarthritis (HP:0002758)2.88756844
55Intestinal atresia (HP:0011100)2.86872897
56Barrel-shaped chest (HP:0001552)2.81030967
57Neoplasm of the adrenal gland (HP:0100631)2.75721198
58Mesomelia (HP:0003027)2.72531143
59Vascular calcification (HP:0004934)2.72339352
60Abnormal vertebral ossification (HP:0100569)2.70413928
61Thoracolumbar scoliosis (HP:0002944)2.68264347
62Conjunctival hamartoma (HP:0100780)2.68166575
63Abnormality of methionine metabolism (HP:0010901)2.67992706
64Fibular hypoplasia (HP:0003038)2.67193390
65Platyspondyly (HP:0000926)2.65297211
66Abnormality of the frontal sinuses (HP:0002687)2.62813425
67Abnormality of vitamin metabolism (HP:0100508)2.61180017
68Proximal tubulopathy (HP:0000114)2.59762041
69Abnormal protein glycosylation (HP:0012346)2.56396149
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.56396149
71Cardiovascular calcification (HP:0011915)2.55937459
72Patchy hypopigmentation of hair (HP:0011365)2.52892926
73Vertebral hypoplasia (HP:0008417)2.51281095
74Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.51281095
75Tongue fasciculations (HP:0001308)2.50947572
76Renal cortical cysts (HP:0000803)2.50168279
77Hamartoma of the eye (HP:0010568)2.50093261
78Protuberant abdomen (HP:0001538)2.49892552
79Aplasia/hypoplasia of the femur (HP:0005613)2.47623955
80Hypomagnesemia (HP:0002917)2.47402632
81Abnormality of the proximal phalanges of the hand (HP:0009834)2.46731489
82Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.46389928
83Abnormality of the phalanges of the 2nd finger (HP:0009541)2.45358011
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.42908238
85Abnormality of carpal bone ossification (HP:0006257)2.42464987
86Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.37163646
87Hypokinesia (HP:0002375)2.34259744
88Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34052835
89Methylmalonic aciduria (HP:0012120)2.32335926
90Thin ribs (HP:0000883)2.29996593
91Glossoptosis (HP:0000162)2.29411189
92Abnormality of the phalanges of the 5th finger (HP:0004213)2.28894373
93Disproportionate short-trunk short stature (HP:0003521)2.28275565
94Prominent metopic ridge (HP:0005487)2.27463453
95Aplasia/Hypoplasia of the fovea (HP:0008060)2.25267805
96Hypoplasia of the fovea (HP:0007750)2.25267805
97Abnormality of the pubic bones (HP:0003172)2.25158210
98Abnormality of the renal cortex (HP:0011035)2.24250649
99Patent foramen ovale (HP:0001655)2.23108485
100Micromelia (HP:0002983)2.22889075
101Progressive macrocephaly (HP:0004481)2.22568123
102Coxa vara (HP:0002812)2.22283624
103Hypoplasia of the odontoid process (HP:0003311)2.18934282
104Ovoid vertebral bodies (HP:0003300)2.18137831
105Ketosis (HP:0001946)2.16496139
106Enlarged epiphyses (HP:0010580)2.15357573
107Hypoplastic ilia (HP:0000946)2.15014322
108White forelock (HP:0002211)2.13626002
109Orthostatic hypotension (HP:0001278)2.13417207
110Type I transferrin isoform profile (HP:0003642)2.12025016
111Abnormality of the vitamin B12 metabolism (HP:0004341)2.10270656
112Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08710798
113Cutaneous melanoma (HP:0012056)2.08111991
114Spinal cord lesions (HP:0100561)2.07379961
115Syringomyelia (HP:0003396)2.07379961
116Hypoplastic scapulae (HP:0000882)2.07158578
117Aplasia/Hypoplasia of the scapulae (HP:0006713)2.07158578
118Decreased skull ossification (HP:0004331)2.06174314
119Albinism (HP:0001022)2.05597710
120Flared metaphyses (HP:0003015)2.05040510
121Thyroid carcinoma (HP:0002890)2.01418494
122Aplasia/Hypoplasia involving the vertebral column (HP:0008518)2.00595942
123Hypolipoproteinemia (HP:0010981)1.98795851
124Meningioma (HP:0002858)1.97533072
125Deep philtrum (HP:0002002)1.95845908
126Thrombocytosis (HP:0001894)1.95456348
127Coxa valga (HP:0002673)1.94875976
128Vacuolated lymphocytes (HP:0001922)1.94194769
129Increased CSF protein (HP:0002922)1.93400420
130Steatorrhea (HP:0002570)1.92745292
131Acute necrotizing encephalopathy (HP:0006965)1.92399075
132Hepatic necrosis (HP:0002605)1.91941653
133Neoplasm of the adrenal cortex (HP:0100641)1.91213036
134Palpitations (HP:0001962)1.90105263
135Hypoplastic iliac wings (HP:0002866)1.89502753
136Hypoproteinemia (HP:0003075)1.89417423
137Increased CSF lactate (HP:0002490)1.88260334
138Hypoplastic pelvis (HP:0008839)1.87956084
139Muscle fibrillation (HP:0010546)1.87872187
140Thyroiditis (HP:0100646)1.87211137
141Abnormality of the metopic suture (HP:0005556)1.86930864
142Neuroendocrine neoplasm (HP:0100634)1.85241641
143Fat malabsorption (HP:0002630)1.84753044
144Progressive inability to walk (HP:0002505)1.83533151
145Intrahepatic cholestasis (HP:0001406)1.83416986
146Abnormal hand bone ossification (HP:0010660)1.83406535
147Acute encephalopathy (HP:0006846)1.83206159
148Prolonged partial thromboplastin time (HP:0003645)1.83128352
149Abnormality of the calcaneus (HP:0008364)1.82260847
150Pheochromocytoma (HP:0002666)1.79739614
151Limited elbow extension (HP:0001377)1.79025129
152Abnormality of the fovea (HP:0000493)1.78492582
153Abnormality of the wing of the ilium (HP:0011867)1.77812683
154Exostoses (HP:0100777)1.77479670
155Generalized hypopigmentation (HP:0007513)1.77237417
156Abnormality of the lumbar spine (HP:0100712)1.76586898
157Abnormality of skull ossification (HP:0002703)1.76258265
158Cystic hygroma (HP:0000476)1.75212886
159Reduced antithrombin III activity (HP:0001976)1.75111468
160Fair hair (HP:0002286)1.74034093
161Hemiparesis (HP:0001269)1.72718943
162Abnormality of the odontoid process (HP:0003310)1.72642569
163Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71809634
164Epidermoid cyst (HP:0200040)1.71493982
165Broad phalanx (HP:0006009)1.70780857
166Volvulus (HP:0002580)1.70424270
167Abnormality of glycolysis (HP:0004366)1.69655966
168Chromsome breakage (HP:0040012)1.69412619
169Spinal cord compression (HP:0002176)1.69383977
170Adrenal hypoplasia (HP:0000835)1.68724285
171Glioma (HP:0009733)1.67339838
172Muscular hypotonia of the trunk (HP:0008936)1.67252277
173Submucous cleft hard palate (HP:0000176)1.66949917
174Ependymoma (HP:0002888)1.66709425
175Papillary thyroid carcinoma (HP:0002895)1.66141334
176Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.65698574
177Abnormality of the intrinsic pathway (HP:0010989)1.65606717
178Abnormal protein N-linked glycosylation (HP:0012347)1.65550095
179Abnormal glycosylation (HP:0012345)1.65550095
180Generalized hypopigmentation of hair (HP:0011358)1.64789800
181Unilateral renal agenesis (HP:0000122)1.63914155
182Insulin-resistant diabetes mellitus (HP:0000831)1.63257018
183Abnormality of urine glucose concentration (HP:0011016)1.62731366
184Glycosuria (HP:0003076)1.62731366
185Abnormal albumin level (HP:0012116)1.60137202
186Hypoalbuminemia (HP:0003073)1.60137202
187Congenital stationary night blindness (HP:0007642)1.60094563
188Breast carcinoma (HP:0003002)1.59139102
189Rhabdomyosarcoma (HP:0002859)1.58951922
190Abnormal biliary tract morphology (HP:0012440)1.58679725
191Medial flaring of the eyebrow (HP:0010747)1.58383482
192Abnormality of magnesium homeostasis (HP:0004921)1.57499937
193Abnormality of calcium-phosphate metabolism (HP:0100530)1.57183531
194Epiphyseal stippling (HP:0010655)1.56207842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.08435060
2ERBB33.86920771
3MAP3K32.86379038
4AKT32.62592530
5STK242.53632137
6ZAK2.48577798
7IRAK42.42214145
8MAP3K142.39451669
9PRPF4B2.32869169
10FRK2.31134355
11STK38L2.28379994
12WNK32.26992704
13EIF2AK12.16830874
14IRAK32.13718428
15EIF2AK32.10358714
16SIK32.06334407
17NUAK12.05496235
18BRSK22.01262121
19MKNK11.94228653
20BMPR21.92894716
21PLK21.86564758
22MKNK21.77850060
23MAP4K21.77101143
24CASK1.76698295
25TRPM71.76246967
26NEK11.72872202
27TSSK61.68694560
28GRK11.65240234
29FGFR21.58517413
30PLK31.58277857
31DDR21.56352071
32CDK81.55550218
33NME11.53254890
34MST41.48801624
35SGK21.47354121
36FER1.45599019
37CLK11.44053838
38PASK1.43713679
39NEK91.43392741
40TEC1.40231500
41PRKG21.40033600
42PBK1.39711580
43PIM21.35136820
44TAOK21.29812756
45MAP3K21.29689572
46STK391.25085627
47SRPK11.18059156
48NLK1.17787965
49BMPR1B1.17213258
50PLK41.14909524
51CSNK1G11.14398150
52TAOK31.14277231
53VRK11.14183814
54RPS6KB11.13443690
55STK161.13116237
56NEK61.10819300
57CDC71.10180554
58SCYL21.07575142
59PDK21.07160192
60TXK1.06984735
61PAK31.06883688
62TESK11.02696421
63CCNB11.01249222
64ACVR1B0.98029099
65YES10.97684655
66EIF2AK20.97207945
67STK30.93141919
68PRKCE0.89798547
69OXSR10.88227460
70WNK40.87887873
71MAP3K120.87869564
72PNCK0.87564163
73CSNK1G30.84902463
74PIM10.83256734
75MAP2K30.82282850
76RPS6KA60.81407083
77RPS6KC10.79367124
78RPS6KL10.79367124
79SGK30.77734352
80BCR0.75902577
81BRSK10.75668485
82ATR0.75452461
83FLT30.72650210
84CSNK1G20.68380792
85TGFBR10.66415581
86LIMK10.65523014
87PRKD30.65138635
88CHUK0.63841358
89TTK0.61036731
90INSRR0.61008347
91MAP2K60.60498543
92MAP2K70.59771179
93RPS6KA40.59467608
94SGK4940.59429486
95SGK2230.59429486
96JAK30.59105120
97TGFBR20.58954771
98CSNK1A1L0.58533795
99LATS10.58467547
100STK40.57787678
101WEE10.56852784
102PIK3CA0.54956478
103CDC42BPA0.54279804
104PHKG20.54039391
105PHKG10.54039391
106NTRK30.53725629
107CDK70.51692468
108TNIK0.50105358
109RPS6KA20.48868528
110CDK30.48197851
111MYLK0.48062536
112STK100.47598167
113ADRBK10.47543599
114BTK0.47434749
115ATM0.47312871
116JAK10.47064208
117ERBB40.46886849
118FGFR10.46768431
119BUB10.45832345
120KIT0.44969487
121PLK10.44796272
122IKBKB0.41142803
123MAP3K50.40915359
124CSNK2A10.39518266
125MAPK130.39408702
126AURKB0.38368361
127PRKCI0.37967346
128CAMK2D0.37838721
129KSR10.37345220
130PRKCD0.36799035
131IGF1R0.36782310
132NME20.35564303
133CAMKK20.35359297
134CDK60.34787142
135GSK3A0.34480078
136PRKAA20.33841295
137MAPK30.33733471
138EPHA30.33350665
139ADRBK20.32612832
140ABL10.31842611
141BRAF0.31242232
142DYRK1A0.30872992
143PIK3CG0.30466444
144BRD40.29700063
145PRKCG0.28876682
146FGFR30.28832595
147CSNK1A10.28805899
148MAP2K10.28312712
149IRAK10.28068742
150PTK2B0.23430234

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.76319177
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.79913573
3DNA replication_Homo sapiens_hsa030302.96286444
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95530238
5Fatty acid elongation_Homo sapiens_hsa000622.71103731
6Base excision repair_Homo sapiens_hsa034102.61510433
7Butanoate metabolism_Homo sapiens_hsa006502.60823313
8Propanoate metabolism_Homo sapiens_hsa006402.60020044
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50507628
10Mismatch repair_Homo sapiens_hsa034302.46448942
11Vitamin B6 metabolism_Homo sapiens_hsa007502.36255569
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34911141
13Homologous recombination_Homo sapiens_hsa034402.15065568
14SNARE interactions in vesicular transport_Homo sapiens_hsa041302.13605176
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.09669594
16Non-homologous end-joining_Homo sapiens_hsa034502.09132856
17* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03319460
18Sulfur metabolism_Homo sapiens_hsa009201.95659588
19Nucleotide excision repair_Homo sapiens_hsa034201.93776643
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93666950
21One carbon pool by folate_Homo sapiens_hsa006701.91460492
22N-Glycan biosynthesis_Homo sapiens_hsa005101.90455734
23ECM-receptor interaction_Homo sapiens_hsa045121.83105988
24Proteasome_Homo sapiens_hsa030501.82974350
25Basal transcription factors_Homo sapiens_hsa030221.73995579
26RNA degradation_Homo sapiens_hsa030181.66820981
27Protein digestion and absorption_Homo sapiens_hsa049741.66018921
28Cell cycle_Homo sapiens_hsa041101.62445652
29Other glycan degradation_Homo sapiens_hsa005111.55764505
30Fanconi anemia pathway_Homo sapiens_hsa034601.54210195
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53479236
32RNA polymerase_Homo sapiens_hsa030201.52581056
33Fatty acid metabolism_Homo sapiens_hsa012121.52530741
34Legionellosis_Homo sapiens_hsa051341.51540567
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.50576416
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47822977
37Peroxisome_Homo sapiens_hsa041461.46838743
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46646125
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.45915392
40Pyrimidine metabolism_Homo sapiens_hsa002401.42667024
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39915629
42Sphingolipid metabolism_Homo sapiens_hsa006001.36219985
43Phagosome_Homo sapiens_hsa041451.29734905
44Tryptophan metabolism_Homo sapiens_hsa003801.29319893
45Vibrio cholerae infection_Homo sapiens_hsa051101.24577693
46RNA transport_Homo sapiens_hsa030131.22965954
47Arachidonic acid metabolism_Homo sapiens_hsa005901.20226232
48Folate biosynthesis_Homo sapiens_hsa007901.20010169
49Galactose metabolism_Homo sapiens_hsa000521.18312285
50Spliceosome_Homo sapiens_hsa030401.17763268
51Circadian rhythm_Homo sapiens_hsa047101.17726713
52Antigen processing and presentation_Homo sapiens_hsa046121.17136877
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15142004
54Fatty acid degradation_Homo sapiens_hsa000711.13150895
55Purine metabolism_Homo sapiens_hsa002301.05138210
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02995991
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02264364
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02177260
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01972842
60Regulation of autophagy_Homo sapiens_hsa041401.01213627
61Starch and sucrose metabolism_Homo sapiens_hsa005000.98809221
62Type I diabetes mellitus_Homo sapiens_hsa049400.96132222
63Collecting duct acid secretion_Homo sapiens_hsa049660.95186136
64Thyroid cancer_Homo sapiens_hsa052160.91451167
65Ether lipid metabolism_Homo sapiens_hsa005650.91141350
66Complement and coagulation cascades_Homo sapiens_hsa046100.90960800
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90604239
68Malaria_Homo sapiens_hsa051440.90011338
69Leishmaniasis_Homo sapiens_hsa051400.89454960
70Steroid biosynthesis_Homo sapiens_hsa001000.87267817
71beta-Alanine metabolism_Homo sapiens_hsa004100.85238238
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.83973313
73Nitrogen metabolism_Homo sapiens_hsa009100.82527913
74Oxidative phosphorylation_Homo sapiens_hsa001900.80209858
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78718537
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78264730
77p53 signaling pathway_Homo sapiens_hsa041150.76528933
78Pyruvate metabolism_Homo sapiens_hsa006200.76441658
79Selenocompound metabolism_Homo sapiens_hsa004500.76067929
80Measles_Homo sapiens_hsa051620.75784202
81Herpes simplex infection_Homo sapiens_hsa051680.75464346
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.74858601
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.72823572
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72344608
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71341983
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70808924
87Mineral absorption_Homo sapiens_hsa049780.70788160
88Phototransduction_Homo sapiens_hsa047440.70173633
89Retinol metabolism_Homo sapiens_hsa008300.69999235
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.68942464
91Influenza A_Homo sapiens_hsa051640.67497184
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64113104
93TGF-beta signaling pathway_Homo sapiens_hsa043500.63533476
94Chemical carcinogenesis_Homo sapiens_hsa052040.63205060
95Insulin secretion_Homo sapiens_hsa049110.62483337
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.62235511
97Hematopoietic cell lineage_Homo sapiens_hsa046400.61519400
98mRNA surveillance pathway_Homo sapiens_hsa030150.60002368
99Epstein-Barr virus infection_Homo sapiens_hsa051690.58757675
100Focal adhesion_Homo sapiens_hsa045100.58434617
101Fat digestion and absorption_Homo sapiens_hsa049750.57184257
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56793957
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.56519493
104Apoptosis_Homo sapiens_hsa042100.56237479
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56201827
106Rheumatoid arthritis_Homo sapiens_hsa053230.54788925
107Allograft rejection_Homo sapiens_hsa053300.54089395
108Caffeine metabolism_Homo sapiens_hsa002320.52959009
109Arginine biosynthesis_Homo sapiens_hsa002200.51855747
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50782944
111Hepatitis B_Homo sapiens_hsa051610.50702117
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50536934
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48292897
114Vitamin digestion and absorption_Homo sapiens_hsa049770.48017813
115Pertussis_Homo sapiens_hsa051330.47909666
116Graft-versus-host disease_Homo sapiens_hsa053320.47270809
117Thyroid hormone synthesis_Homo sapiens_hsa049180.46514828
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46047511
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44842660
120HTLV-I infection_Homo sapiens_hsa051660.44517413
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.43739786
122Carbon metabolism_Homo sapiens_hsa012000.42254331
123ABC transporters_Homo sapiens_hsa020100.41930081
124Prostate cancer_Homo sapiens_hsa052150.40846440
125Renin-angiotensin system_Homo sapiens_hsa046140.39736721
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39653363
127Viral carcinogenesis_Homo sapiens_hsa052030.37837807
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37102729
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36724880
130Oocyte meiosis_Homo sapiens_hsa041140.35826086
131Toxoplasmosis_Homo sapiens_hsa051450.35510916
132Glutathione metabolism_Homo sapiens_hsa004800.33810765
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33444540
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32343450
135Lysine degradation_Homo sapiens_hsa003100.31902192
136Lysosome_Homo sapiens_hsa041420.29530053
137TNF signaling pathway_Homo sapiens_hsa046680.29016200
138Tuberculosis_Homo sapiens_hsa051520.28757967
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28184801
140Shigellosis_Homo sapiens_hsa051310.27192384
141Asthma_Homo sapiens_hsa053100.27001545
142Linoleic acid metabolism_Homo sapiens_hsa005910.25530365
143Parkinsons disease_Homo sapiens_hsa050120.23885940
144Arginine and proline metabolism_Homo sapiens_hsa003300.23722786
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22507453
146Autoimmune thyroid disease_Homo sapiens_hsa053200.22330075
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.19289012
148Olfactory transduction_Homo sapiens_hsa047400.19276836
149Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19201084
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.18886979
151Metabolic pathways_Homo sapiens_hsa011000.17986406
152MicroRNAs in cancer_Homo sapiens_hsa052060.17574167

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »