SSR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.81164377
2Golgi transport vesicle coating (GO:0048200)7.81164377
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.68835731
4protein retention in ER lumen (GO:0006621)5.95020368
5COPII vesicle coating (GO:0048208)5.21607646
6signal peptide processing (GO:0006465)5.19724530
7collagen fibril organization (GO:0030199)4.37251409
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.13272762
9keratan sulfate catabolic process (GO:0042340)4.03958474
10positive regulation of nuclease activity (GO:0032075)4.00061588
11chondrocyte development (GO:0002063)3.95639726
12sequestering of metal ion (GO:0051238)3.89455957
13endoplasmic reticulum unfolded protein response (GO:0030968)3.84317695
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.82685056
15hemidesmosome assembly (GO:0031581)3.79121725
16nuclear pore organization (GO:0006999)3.74120820
17cellular response to unfolded protein (GO:0034620)3.73641079
18regulation of nuclease activity (GO:0032069)3.71367620
19ribosome assembly (GO:0042255)3.67390570
20cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.63037953
21vesicle coating (GO:0006901)3.61261372
22ER-nucleus signaling pathway (GO:0006984)3.60474818
23chondrocyte proliferation (GO:0035988)3.53077849
24nucleobase-containing small molecule interconversion (GO:0015949)3.52530962
25cellular response to topologically incorrect protein (GO:0035967)3.45674330
26ER overload response (GO:0006983)3.43248275
27UDP-N-acetylglucosamine metabolic process (GO:0006047)3.40572467
28nucleotide-sugar biosynthetic process (GO:0009226)3.34061930
29membrane raft organization (GO:0031579)3.30343255
30regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.24478603
31endothelial cell morphogenesis (GO:0001886)3.22872706
32peptidyl-proline hydroxylation (GO:0019511)3.21569288
33cell adhesion mediated by integrin (GO:0033627)3.19947190
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17415315
35protein N-linked glycosylation via asparagine (GO:0018279)3.15149359
36mitotic metaphase plate congression (GO:0007080)3.14954729
37formation of translation preinitiation complex (GO:0001731)3.13241836
38peptidyl-asparagine modification (GO:0018196)3.12255802
394-hydroxyproline metabolic process (GO:0019471)3.10906576
40ventricular cardiac muscle cell development (GO:0055015)3.09827429
41proteasome assembly (GO:0043248)3.08282259
42regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08146766
43cellular response to vitamin D (GO:0071305)3.07218742
44exocrine pancreas development (GO:0031017)3.06278537
45regulation of metalloenzyme activity (GO:0048552)3.05094092
46response to endoplasmic reticulum stress (GO:0034976)3.02616231
47establishment of integrated proviral latency (GO:0075713)3.02412276
48pore complex assembly (GO:0046931)3.01865769
49endodermal cell differentiation (GO:0035987)2.99468356
50retina vasculature morphogenesis in camera-type eye (GO:0061299)2.96183922
51protein localization to chromosome, centromeric region (GO:0071459)2.93752344
52protein hydroxylation (GO:0018126)2.93502122
53protein N-linked glycosylation (GO:0006487)2.89574175
54response to unfolded protein (GO:0006986)2.85907122
55positive regulation of extracellular matrix organization (GO:1903055)2.85547034
56negative regulation of fatty acid transport (GO:2000192)2.85235013
57metaphase plate congression (GO:0051310)2.84586159
58establishment of chromosome localization (GO:0051303)2.83085341
59embryonic skeletal joint morphogenesis (GO:0060272)2.82452917
60peptide catabolic process (GO:0043171)2.81789820
61protein localization to kinetochore (GO:0034501)2.81174756
62type B pancreatic cell development (GO:0003323)2.80860936
63collagen metabolic process (GO:0032963)2.79740510
64regulation of translational fidelity (GO:0006450)2.79571052
65protein localization to endosome (GO:0036010)2.77176569
66cellular protein complex localization (GO:0034629)2.75677646
67apoptotic cell clearance (GO:0043277)2.74759166
68skin morphogenesis (GO:0043589)2.74626197
69regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.73787870
70ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.73449586
71collagen catabolic process (GO:0030574)2.71909475
72cell-substrate junction assembly (GO:0007044)2.71571883
73substrate adhesion-dependent cell spreading (GO:0034446)2.70984838
74regulation of mitotic spindle organization (GO:0060236)2.70905338
75protein maturation by protein folding (GO:0022417)2.70597670
76mitotic sister chromatid segregation (GO:0000070)2.69975580
77ER to Golgi vesicle-mediated transport (GO:0006888)2.69971326
78regulation of translational termination (GO:0006449)2.68626366
79response to topologically incorrect protein (GO:0035966)2.68274404
80mesenchymal-epithelial cell signaling (GO:0060638)2.64934091
81regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.64919748
82mitotic chromosome condensation (GO:0007076)2.58994536
83protein heterotrimerization (GO:0070208)2.58713976
84cellular response to vitamin (GO:0071295)2.58345779
85multicellular organismal macromolecule metabolic process (GO:0044259)2.57072043
86multicellular organismal catabolic process (GO:0044243)2.56767618
87multicellular organismal metabolic process (GO:0044236)2.56290387
88regulation of transforming growth factor beta1 production (GO:0032908)2.53764297
89protein carboxylation (GO:0018214)2.52389023
90peptidyl-glutamic acid carboxylation (GO:0017187)2.52389023
91negative regulation of DNA repair (GO:0045738)2.51402023
92substrate-dependent cell migration (GO:0006929)2.50821198
93tRNA aminoacylation for protein translation (GO:0006418)2.50710194
94sister chromatid segregation (GO:0000819)2.50291661
95extracellular matrix disassembly (GO:0022617)2.49984728
96cell migration involved in sprouting angiogenesis (GO:0002042)2.48744262
97regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48556674
98protein heterotetramerization (GO:0051290)2.47766491
99negative regulation of glycogen biosynthetic process (GO:0045719)2.47620648
100sprouting angiogenesis (GO:0002040)2.45344940
101notochord development (GO:0030903)2.45242061
102amino acid activation (GO:0043038)2.43738366
103tRNA aminoacylation (GO:0043039)2.43738366
104hippo signaling (GO:0035329)2.40402475
105nucleotide-sugar metabolic process (GO:0009225)2.39421058
106gland morphogenesis (GO:0022612)2.37746576
107positive regulation of protein autophosphorylation (GO:0031954)2.37013516
108cell redox homeostasis (GO:0045454)2.36897477
109lung vasculature development (GO:0060426)2.36851157
110regulation of integrin-mediated signaling pathway (GO:2001044)2.36796522
111positive regulation of endothelial cell apoptotic process (GO:2000353)2.36594637
112establishment of viral latency (GO:0019043)2.36263487
113positive regulation of osteoblast proliferation (GO:0033690)2.35895824
114ribosomal large subunit biogenesis (GO:0042273)2.35752093
115hyaluronan catabolic process (GO:0030214)2.35194753
116chaperone-mediated protein folding (GO:0061077)2.35094066
117paraxial mesoderm development (GO:0048339)2.32729778
118glucocorticoid receptor signaling pathway (GO:0042921)2.32407602
119negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.32024283
120negative regulation of anoikis (GO:2000811)2.31860110
121regulation of transforming growth factor beta2 production (GO:0032909)2.29450007
122deoxyribonucleotide biosynthetic process (GO:0009263)2.29208700
123protein complex localization (GO:0031503)2.29204970
124mitotic nuclear envelope disassembly (GO:0007077)2.29050430
125wound healing, spreading of cells (GO:0044319)2.27452638
126positive regulation of hormone biosynthetic process (GO:0046886)2.26657924
127branching involved in prostate gland morphogenesis (GO:0060442)2.26638698
128cytoskeleton-dependent cytokinesis (GO:0061640)2.25982095
129iron ion import (GO:0097286)2.25848817
130membrane budding (GO:0006900)2.25367720
131sequestering of extracellular ligand from receptor (GO:0035581)2.24411948
132mesodermal cell differentiation (GO:0048333)2.22307309
133basement membrane organization (GO:0071711)2.20898969
134insulin-like growth factor receptor signaling pathway (GO:0048009)2.19614776
135endocardial cushion development (GO:0003197)2.18957817
136glycoprotein catabolic process (GO:0006516)2.18645593
137regulation of interleukin-8 secretion (GO:2000482)2.18596650
138regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.18241493
139negative regulation of chondrocyte differentiation (GO:0032331)2.18030817
140cartilage condensation (GO:0001502)2.17760813
141cell aggregation (GO:0098743)2.17760813
142glandular epithelial cell development (GO:0002068)2.16721445
143positive regulation of macrophage activation (GO:0043032)2.15722555
144regulation of extracellular matrix disassembly (GO:0010715)2.15544489
145wound healing, spreading of epidermal cells (GO:0035313)2.15011631
146cellular response to ATP (GO:0071318)2.14943802
147cellular glucuronidation (GO:0052695)2.13261849
148nucleotide transmembrane transport (GO:1901679)2.12974388
149regulation of plasminogen activation (GO:0010755)2.12179843
150regulation of apoptotic cell clearance (GO:2000425)2.11416818
151negative regulation of cartilage development (GO:0061037)2.10695011
152positive regulation of epithelial to mesenchymal transition (GO:0010718)2.09722063
153nuclear pore complex assembly (GO:0051292)2.09642968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.85241741
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.34396882
3CLOCK_20551151_ChIP-Seq_293T_Human3.32353738
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.27859346
5E2F7_22180533_ChIP-Seq_HELA_Human3.04919937
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.98910468
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98580248
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.73083660
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55862986
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53087430
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.49733177
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48564745
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40217915
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.40094451
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36747820
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.35223428
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31305980
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.22148797
19* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16864547
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.16217725
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15381996
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.13188836
23SALL4_18804426_ChIP-ChIP_XEN_Mouse2.09454688
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08026138
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04963690
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.03014263
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02365098
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98605797
29AR_21909140_ChIP-Seq_LNCAP_Human1.96752538
30DCP1A_22483619_ChIP-Seq_HELA_Human1.95154104
31BRD4_25478319_ChIP-Seq_HGPS_Human1.95148959
32GATA1_22025678_ChIP-Seq_K562_Human1.94897711
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.92118972
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91113046
35CJUN_26792858_Chip-Seq_BT549_Human1.90121820
36* ELK1_19687146_ChIP-ChIP_HELA_Human1.89960532
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.89710167
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83564735
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.83540274
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.81930166
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.81459191
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79527004
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78872449
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78872449
45* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72650380
46* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72650380
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71437668
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70440727
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70058276
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69994353
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.68694548
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67206035
53SOX2_20726797_ChIP-Seq_SW620_Human1.65508872
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.63130721
55NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.62522218
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60174528
57* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58256852
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57557165
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56002611
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.45435326
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44972062
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.44142530
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43479131
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43312327
65FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.42989353
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42184117
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40779231
68HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38176194
69* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32234616
70* ETS1_20019798_ChIP-Seq_JURKAT_Human1.32190633
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31860971
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.31676897
73* TFEB_21752829_ChIP-Seq_HELA_Human1.30339144
74ZNF263_19887448_ChIP-Seq_K562_Human1.29693917
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28246010
76ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28160183
77* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27408965
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27308722
79* GATA4_25053715_ChIP-Seq_YYC3_Human1.26679541
80CHD1_26751641_Chip-Seq_LNCaP_Human1.25339885
81GATA3_24758297_ChIP-Seq_MCF-7_Human1.25148369
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23934353
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23331516
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.22102253
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21612933
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20992828
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20790445
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20485267
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.19030783
90GATA4_21415370_ChIP-Seq_HL-1_Mouse1.18286440
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17667078
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17497279
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.15632763
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.15479391
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15236151
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14836707
97* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13799386
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13589594
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12738021
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11940839
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11935554
102* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11584890
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.10029575
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09722494
105* SOX17_20123909_ChIP-Seq_XEN_Mouse1.07789441
106* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07707931
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07262302
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06814129
109TTF2_22483619_ChIP-Seq_HELA_Human1.06560991
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06539177
111MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06116604
112TP53_18474530_ChIP-ChIP_U2OS_Human1.05887064
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05601278
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04655614
115* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.04317801
116ATF3_27146783_Chip-Seq_COLON_Human1.03384663
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02351228
118GABP_19822575_ChIP-Seq_HepG2_Human1.02158499
119EP300_21415370_ChIP-Seq_HL-1_Mouse1.01801956
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01358608
121* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00573031
122THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99948936
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99667566
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98998931
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98905504
126SRF_21415370_ChIP-Seq_HL-1_Mouse0.97836086
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97383059
128XRN2_22483619_ChIP-Seq_HELA_Human0.97301011
129MYC_18555785_ChIP-Seq_MESCs_Mouse0.96220938
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94701425
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93761772
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.93387266
133FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93245885
134KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93079054
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92770555
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92672974
137FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.90957590
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90846588
139JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90695131
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89760749
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89151111
142FOXM1_23109430_ChIP-Seq_U2OS_Human0.88925725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.02843986
2MP0003950_abnormal_plasma_membrane4.00881636
3MP0005503_abnormal_tendon_morphology3.41511187
4MP0003705_abnormal_hypodermis_morpholog3.32951015
5MP0006054_spinal_hemorrhage3.25646174
6MP0002877_abnormal_melanocyte_morpholog3.16895852
7MP0005275_abnormal_skin_tensile2.94838097
8MP0009384_cardiac_valve_regurgitation2.43261668
9MP0004272_abnormal_basement_membrane2.41533843
10MP0004957_abnormal_blastocyst_morpholog2.07419171
11MP0003279_aneurysm2.02756143
12MP0010352_gastrointestinal_tract_polyps1.89664094
13MP0003566_abnormal_cell_adhesion1.77734531
14MP0002896_abnormal_bone_mineralization1.74139108
15MP0009053_abnormal_anal_canal1.71775769
16MP0001958_emphysema1.62404414
17MP0002282_abnormal_trachea_morphology1.59209136
18MP0005508_abnormal_skeleton_morphology1.59034428
19MP0005408_hypopigmentation1.58685416
20MP0005220_abnormal_exocrine_pancreas1.55090417
21MP0004134_abnormal_chest_morphology1.52417296
22MP0008932_abnormal_embryonic_tissue1.49375247
23MP0000163_abnormal_cartilage_morphology1.48582496
24MP0009250_abnormal_appendicular_skeleto1.45209634
25MP0005023_abnormal_wound_healing1.39269346
26MP0003111_abnormal_nucleus_morphology1.37607613
27MP0002060_abnormal_skin_morphology1.36909667
28MP0002115_abnormal_skeleton_extremities1.36247960
29MP0002933_joint_inflammation1.35709184
30MP0004233_abnormal_muscle_weight1.35036654
31MP0010368_abnormal_lymphatic_system1.34892123
32MP0004084_abnormal_cardiac_muscle1.31640933
33MP0001299_abnormal_eye_distance/1.30945841
34MP0003195_calcinosis1.30858516
35MP0002139_abnormal_hepatobiliary_system1.29730405
36MP0003300_gastrointestinal_ulcer1.29690750
37MP0003252_abnormal_bile_duct1.28400748
38MP0009780_abnormal_chondrocyte_physiolo1.28024217
39MP0001879_abnormal_lymphatic_vessel1.27879555
40MP0000749_muscle_degeneration1.27872103
41MP0000537_abnormal_urethra_morphology1.25836605
42MP0001661_extended_life_span1.22269044
43MP0003077_abnormal_cell_cycle1.22257674
44MP0005076_abnormal_cell_differentiation1.21162771
45MP0003191_abnormal_cellular_cholesterol1.20089959
46MP0003123_paternal_imprinting1.19713777
47MP0010094_abnormal_chromosome_stability1.18861127
48MP0005390_skeleton_phenotype1.17464606
49MP0002295_abnormal_pulmonary_circulatio1.16568786
50MP0002113_abnormal_skeleton_development1.16298626
51MP0003693_abnormal_embryo_hatching1.16201372
52MP0001542_abnormal_bone_strength1.15783921
53MP0009697_abnormal_copulation1.14971639
54MP0005257_abnormal_intraocular_pressure1.13763903
55MP0003868_abnormal_feces_composition1.12984424
56MP0004264_abnormal_extraembryonic_tissu1.12538781
57MP0003942_abnormal_urinary_system1.12517164
58MP0010030_abnormal_orbit_morphology1.11731131
59MP0004197_abnormal_fetal_growth/weight/1.11694643
60MP0003806_abnormal_nucleotide_metabolis1.11668154
61MP0005367_renal/urinary_system_phenotyp1.09552452
62MP0000516_abnormal_urinary_system1.09552452
63MP0003795_abnormal_bone_structure1.07992885
64MP0001730_embryonic_growth_arrest1.07013708
65MP0001243_abnormal_dermal_layer1.06209067
66MP0001533_abnormal_skeleton_physiology1.05665636
67MP0000767_abnormal_smooth_muscle1.03822838
68MP0000358_abnormal_cell_content/1.03258873
69MP0001672_abnormal_embryogenesis/_devel1.00999107
70MP0005380_embryogenesis_phenotype1.00999107
71MP0003091_abnormal_cell_migration1.00605676
72MP0005197_abnormal_uvea_morphology1.00123808
73MP0001348_abnormal_lacrimal_gland0.99120214
74MP0000350_abnormal_cell_proliferation0.98824404
75MP0003984_embryonic_growth_retardation0.96345899
76MP0002086_abnormal_extraembryonic_tissu0.96287183
77MP0005165_increased_susceptibility_to0.96174360
78MP0000013_abnormal_adipose_tissue0.95790601
79MP0002084_abnormal_developmental_patter0.94350184
80MP0001697_abnormal_embryo_size0.93304021
81MP0003786_premature_aging0.93130869
82MP0002109_abnormal_limb_morphology0.93051776
83MP0002088_abnormal_embryonic_growth/wei0.91838743
84MP0005365_abnormal_bile_salt0.91029727
85MP0003385_abnormal_body_wall0.89484683
86MP0004782_abnormal_surfactant_physiolog0.89282386
87MP0003186_abnormal_redox_activity0.88765040
88MP0003890_abnormal_embryonic-extraembry0.88104019
89MP0005623_abnormal_meninges_morphology0.87680176
90MP0000733_abnormal_muscle_development0.87659566
91MP0000428_abnormal_craniofacial_morphol0.86921908
92MP0003115_abnormal_respiratory_system0.86577053
93MP0005193_abnormal_anterior_eye0.84986643
94MP0005621_abnormal_cell_physiology0.84609398
95MP0003448_altered_tumor_morphology0.84471509
96MP0002085_abnormal_embryonic_tissue0.83850301
97MP0003283_abnormal_digestive_organ0.83831640
98MP0002080_prenatal_lethality0.83502470
99MP0005058_abnormal_lysosome_morphology0.83355716
100MP0005330_cardiomyopathy0.83109246
101MP0000751_myopathy0.82447503
102MP0002928_abnormal_bile_duct0.82089712
103MP0003943_abnormal_hepatobiliary_system0.81994462
104MP0001944_abnormal_pancreas_morphology0.81561903
105MP0010307_abnormal_tumor_latency0.81381238
106MP0002938_white_spotting0.80735010
107MP0003755_abnormal_palate_morphology0.80620585
108MP0001881_abnormal_mammary_gland0.80425095
109MP0005248_abnormal_Harderian_gland0.80355644
110MP0000003_abnormal_adipose_tissue0.80039832
111MP0002108_abnormal_muscle_morphology0.78291580
112MP0005360_urolithiasis0.77786883
113MP0002998_abnormal_bone_remodeling0.77438442
114MP0002254_reproductive_system_inflammat0.77359218
115MP0000759_abnormal_skeletal_muscle0.76734245
116MP0002269_muscular_atrophy0.76189515
117MP0005501_abnormal_skin_physiology0.75943656
118MP0005084_abnormal_gallbladder_morpholo0.75920858
119MP0005083_abnormal_biliary_tract0.75881810
120MP0005171_absent_coat_pigmentation0.75775669
121MP0000747_muscle_weakness0.75133691
122MP0008007_abnormal_cellular_replicative0.74669199
123MP0002932_abnormal_joint_morphology0.74587375
124MP0010234_abnormal_vibrissa_follicle0.73280734
125MP0005085_abnormal_gallbladder_physiolo0.73241917
126MP0003937_abnormal_limbs/digits/tail_de0.72706926
127MP0001849_ear_inflammation0.72656985
128MP0005384_cellular_phenotype0.72378411
129MP0002697_abnormal_eye_size0.72061319
130MP0002128_abnormal_blood_circulation0.72044601
131MP0001175_abnormal_lung_morphology0.71684104
132MP0001915_intracranial_hemorrhage0.71565122
133MP0003935_abnormal_craniofacial_develop0.71398523
134MP0001216_abnormal_epidermal_layer0.70986832
135MP0003221_abnormal_cardiomyocyte_apopto0.69995093
136MP0001666_abnormal_nutrient_absorption0.69945244
137MP0001270_distended_abdomen0.69667714
138MP0000432_abnormal_head_morphology0.69653466
139MP0000534_abnormal_ureter_morphology0.69213028
140MP0004087_abnormal_muscle_fiber0.69106314
141MP0000762_abnormal_tongue_morphology0.69015891
142MP0000858_altered_metastatic_potential0.68847552
143MP0002111_abnormal_tail_morphology0.68743190
144MP0005451_abnormal_body_composition0.68509556
145MP0002089_abnormal_postnatal_growth/wei0.67763411
146MP0001177_atelectasis0.67637406
147MP0003122_maternal_imprinting0.67274911
148MP0005164_abnormal_response_to0.65151984
149MP0003941_abnormal_skin_development0.64981028

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)4.78385127
2Protrusio acetabuli (HP:0003179)4.10931106
3Cervical subluxation (HP:0003308)4.04921558
4Premature rupture of membranes (HP:0001788)3.97253934
5Abnormal foot bone ossification (HP:0010675)3.66333793
6Vitreoretinal degeneration (HP:0000655)3.64097357
7Cupped ribs (HP:0000887)3.57932968
8Hypoplastic ischia (HP:0003175)3.51151755
9Irregular epiphyses (HP:0010582)3.48706602
10Abnormal tarsal ossification (HP:0008369)3.48073453
11Abnormality of the ischium (HP:0003174)3.35262244
12Neonatal short-limb short stature (HP:0008921)2.98408992
13Aortic aneurysm (HP:0004942)2.95601705
14Thoracolumbar scoliosis (HP:0002944)2.91227940
15Fragile skin (HP:0001030)2.86603765
16Metaphyseal cupping (HP:0003021)2.84455828
17Flat acetabular roof (HP:0003180)2.82605461
18Beaking of vertebral bodies (HP:0004568)2.79847206
19Abnormality of the intrinsic pathway (HP:0010989)2.76588693
20Amniotic constriction ring (HP:0009775)2.75702518
21Abnormality of placental membranes (HP:0011409)2.75702518
22Wormian bones (HP:0002645)2.72522266
23Aortic dissection (HP:0002647)2.68823041
24Flat capital femoral epiphysis (HP:0003370)2.67268455
25Platyspondyly (HP:0000926)2.63837940
26Ankyloglossia (HP:0010296)2.63653343
27Osteoarthritis (HP:0002758)2.62226576
28Small epiphyses (HP:0010585)2.60762808
29Mesomelia (HP:0003027)2.60099468
30Exostoses (HP:0100777)2.58755476
31Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.56061607
32Abnormality of dentin (HP:0010299)2.54336037
33Syringomyelia (HP:0003396)2.53925769
34Spinal cord lesions (HP:0100561)2.53925769
35Delayed epiphyseal ossification (HP:0002663)2.53085002
36Abnormalities of placenta or umbilical cord (HP:0001194)2.49755652
37Pterygium (HP:0001059)2.49621769
38Abnormality of the umbilical cord (HP:0010881)2.49234739
39Soft skin (HP:0000977)2.48368460
40Subacute progressive viral hepatitis (HP:0006572)2.46361367
41Elbow flexion contracture (HP:0002987)2.45116587
42Spondylolisthesis (HP:0003302)2.43243912
43Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.40539929
44Vertebral compression fractures (HP:0002953)2.40162370
45Abnormality of oral frenula (HP:0000190)2.36693793
46Blue sclerae (HP:0000592)2.36692318
47Cardiovascular calcification (HP:0011915)2.36622409
48Osteolytic defects of the hand bones (HP:0009699)2.32627227
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.32627227
50Protuberant abdomen (HP:0001538)2.32236841
51Abnormal delivery (HP:0001787)2.27256472
52Type 1 muscle fiber predominance (HP:0003803)2.26023056
53Abnormality of the acetabulum (HP:0003170)2.26021287
54Popliteal pterygium (HP:0009756)2.25801553
55Hepatoblastoma (HP:0002884)2.24723118
56Entropion (HP:0000621)2.23171474
57Hypoglycemic coma (HP:0001325)2.22197892
58Metaphyseal dysplasia (HP:0100255)2.20937056
59Reduced subcutaneous adipose tissue (HP:0003758)2.20421046
60Abnormal vertebral ossification (HP:0100569)2.19744856
61Follicular hyperkeratosis (HP:0007502)2.19214397
62Vascular tortuosity (HP:0004948)2.18985688
63Abnormality of carpal bone ossification (HP:0006257)2.18677850
64Absent frontal sinuses (HP:0002688)2.17744832
65Vertebral hypoplasia (HP:0008417)2.17078687
66Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.17078687
67Ankle contracture (HP:0006466)2.16958369
68Atrophic scars (HP:0001075)2.15747936
69Spinal rigidity (HP:0003306)2.15587046
70Flattened epiphyses (HP:0003071)2.15180653
71Coxa vara (HP:0002812)2.13777672
72Mild short stature (HP:0003502)2.13016403
73Abnormality of the common coagulation pathway (HP:0010990)2.12670420
74Abnormality of the calcaneus (HP:0008364)2.12305975
75Biconcave vertebral bodies (HP:0004586)2.10907042
76Breech presentation (HP:0001623)2.09107736
77Generalized amyotrophy (HP:0003700)2.08953484
78Hypoplasia of the odontoid process (HP:0003311)2.08497394
79Ovoid vertebral bodies (HP:0003300)2.08428971
80Abnormality of the fetal cardiovascular system (HP:0010948)2.07611766
81Abnormal umbilical cord blood vessels (HP:0011403)2.07611766
82Single umbilical artery (HP:0001195)2.07611766
83Asymmetry of the thorax (HP:0001555)2.07522683
84Dilatation of the ascending aorta (HP:0005111)2.05813949
85Stillbirth (HP:0003826)2.04897095
86Nonimmune hydrops fetalis (HP:0001790)2.03531300
87Slender build (HP:0001533)2.03032671
88Tetraparesis (HP:0002273)2.02996217
89Abnormality of the frontal sinuses (HP:0002687)2.01903758
90Hyperglycemia (HP:0003074)2.01311933
91Microglossia (HP:0000171)1.99796946
92Abnormality of glycolysis (HP:0004366)1.99139499
93Genu recurvatum (HP:0002816)1.97984105
94Mildly elevated creatine phosphokinase (HP:0008180)1.97268881
95Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95109881
96Mitral stenosis (HP:0001718)1.94807363
97Orthostatic hypotension (HP:0001278)1.94716641
98Abnormal pancreas size (HP:0012094)1.94256817
99Abnormal cartilage morphology (HP:0002763)1.93871440
100Abnormality of the vertebral endplates (HP:0005106)1.93346811
101Onycholysis (HP:0001806)1.92862155
102Irregular vertebral endplates (HP:0003301)1.92520712
103Hyperextensible skin (HP:0000974)1.92372867
104Long clavicles (HP:0000890)1.91402093
105Trismus (HP:0000211)1.91337567
106Abnormality of the lumbar spine (HP:0100712)1.90582033
107Peritonitis (HP:0002586)1.89995513
108Increased serum pyruvate (HP:0003542)1.89499193
109Bowel diverticulosis (HP:0005222)1.89292211
110Abnormality of the distal phalanges of the toes (HP:0010182)1.89251392
111Short 5th finger (HP:0009237)1.88493189
112Knee flexion contracture (HP:0006380)1.88440858
113Short nail (HP:0001799)1.88303847
114Abnormality of methionine metabolism (HP:0010901)1.86474552
115Abnormality of the odontoid process (HP:0003310)1.86396276
116Arterial tortuosity (HP:0005116)1.85964755
117Decreased skull ossification (HP:0004331)1.85863043
118Broad long bones (HP:0005622)1.84993573
119Short middle phalanx of the 5th finger (HP:0004220)1.84905341
120Abnormal ossification of hand bones (HP:0005921)1.84094226
121Nemaline bodies (HP:0003798)1.83793138
122Thin bony cortex (HP:0002753)1.83792501
123Delayed closure of the anterior fontanelle (HP:0001476)1.83326222
124Overgrowth (HP:0001548)1.82883178
125Delayed cranial suture closure (HP:0000270)1.82817829
126Disproportionate short-trunk short stature (HP:0003521)1.82615889
127Hypoglycemic seizures (HP:0002173)1.82520392
128Abnormality of incisor morphology (HP:0011063)1.81362726
129Abnormal hand bone ossification (HP:0010660)1.81070640
130Delayed gross motor development (HP:0002194)1.81057704
131Shallow orbits (HP:0000586)1.78659133
132Genu varum (HP:0002970)1.78424418
133Mitral valve prolapse (HP:0001634)1.78300976
134Bladder diverticulum (HP:0000015)1.78269297
135Coronal craniosynostosis (HP:0004440)1.77321503
136Natal tooth (HP:0000695)1.77182579
137Joint stiffness (HP:0001387)1.73881705
138Broad phalanx (HP:0006009)1.73751341
139Redundant skin (HP:0001582)1.73363120
140Broad face (HP:0000283)1.72928933
141Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72887387
142Ectopia lentis (HP:0001083)1.72749943
143Ulnar bowing (HP:0003031)1.72663416
144Metaphyseal irregularity (HP:0003025)1.71446364
145Termporal pattern (HP:0011008)1.71202431
146Insidious onset (HP:0003587)1.71202431
147Relative macrocephaly (HP:0004482)1.67357947
148Joint laxity (HP:0001388)1.64707389
149Vascular calcification (HP:0004934)1.61899730
150Aortic regurgitation (HP:0001659)1.56840636
151Renal duplication (HP:0000075)1.56292789
152Spinal cord compression (HP:0002176)1.56123994
153Disproportionate tall stature (HP:0001519)1.54642903
154Myocardial infarction (HP:0001658)1.54048746
155Nuclear cataract (HP:0100018)1.53764033
156Kyphoscoliosis (HP:0002751)1.53346243
157Limb-girdle muscle atrophy (HP:0003797)1.52958771
158Upper limb muscle weakness (HP:0003484)1.51159451
159Limb-girdle muscle weakness (HP:0003325)1.50745952
160Selective tooth agenesis (HP:0001592)1.50499974
161Abnormal auditory evoked potentials (HP:0006958)1.49973095
162Rough bone trabeculation (HP:0100670)1.49417640
163Sensory axonal neuropathy (HP:0003390)1.49239104
164Distal upper limb amyotrophy (HP:0007149)1.49011716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.48087601
2ERBB33.05275418
3LATS12.98938537
4DDR22.71362856
5BUB12.68378614
6MAP3K122.46795508
7ERN12.38937326
8NEK92.17858762
9FLT32.15478651
10PKN22.13162290
11SIK12.05813104
12LATS21.97928161
13BRSK21.96450664
14PASK1.93947279
15STK31.93924524
16MAP3K31.90942592
17STK38L1.87525990
18TRIB31.86932212
19PDGFRA1.85759790
20TESK11.83893663
21TTK1.83037081
22TSSK61.82835251
23NUAK11.78536759
24TRPM71.76345939
25EIF2AK31.75905820
26EPHA31.75150124
27RPS6KA41.71879346
28MET1.67710910
29ZAK1.67408800
30PTK61.65520901
31SRPK11.58086026
32SCYL21.57445373
33NME21.54415696
34PIK3CA1.52943547
35TTN1.49926128
36WEE11.46957478
37MOS1.32655041
38TRIM281.28938302
39LIMK11.27439820
40PIK3CG1.25710849
41STK241.25517001
42INSRR1.24622341
43MAP3K141.24500972
44MKNK11.20901252
45TGFBR11.13105945
46PDK21.12358896
47NTRK11.09747449
48PLK21.05332901
49EPHA21.04916926
50LRRK21.01834244
51JAK31.01396787
52MST41.01173134
53PRKG21.00784014
54CLK10.97421872
55CDK60.96144429
56PLK30.94400120
57PAK20.94004408
58BCKDK0.93893849
59PTK20.92024678
60STK100.90904693
61EIF2AK10.86349984
62FGFR10.84336882
63PDGFRB0.80090411
64TIE10.79759002
65FER0.79724124
66MST1R0.79476443
67PAK40.78648684
68FGFR30.78304296
69MUSK0.77633955
70STK160.76349806
71CHUK0.76259830
72PLK10.73331840
73TGFBR20.73227214
74EPHB20.72955954
75ARAF0.71914696
76PRKD30.71063905
77BCR0.71041861
78ERBB40.70611313
79ROCK20.70391094
80EEF2K0.67766273
81ACVR1B0.65726708
82SIK30.65554173
83TAOK30.64592614
84DMPK0.63796300
85FGFR20.63744175
86CHEK20.63729791
87ABL20.62871006
88STK40.62436607
89AKT30.61396885
90MAP2K30.61310608
91KSR10.60976569
92LMTK20.59726942
93PAK30.58028622
94MKNK20.57953577
95GSK3A0.57014995
96BMPR20.56023991
97PIM20.55596342
98NEK20.54722138
99DAPK30.54500538
100CDC70.54376222
101ILK0.54299919
102IRAK30.53802354
103JAK10.52202245
104NEK10.51398324
105BMX0.51275128
106TAF10.51064939
107MTOR0.50831369
108IGF1R0.50433463
109MARK30.50331063
110RPS6KB10.49741210
111MAP3K90.49341990
112BRAF0.47900633
113PBK0.47566265
114MELK0.46931992
115EIF2AK20.45825930
116CDK70.45684275
117MAP3K80.45655496
118PAK10.44888850
119PLK40.44204142
120RPS6KB20.44146799
121ROCK10.43047183
122AURKB0.42512206
123CHEK10.41940003
124BRSK10.41076061
125NEK60.40341090
126IRAK40.36323242
127RAF10.36248444
128AKT20.35435898
129RIPK10.35155186
130DYRK1B0.35145204
131FGFR40.35140995
132ATR0.34317416
133VRK20.33913559
134BMPR1B0.33832878
135MYLK0.33633848
136PIM10.33165563
137INSR0.31846129
138HIPK20.30801655
139CDK80.30308993

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.53226333
2* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.23884402
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.89230253
4Sulfur metabolism_Homo sapiens_hsa009202.88405753
5Proteasome_Homo sapiens_hsa030502.87328960
6ECM-receptor interaction_Homo sapiens_hsa045122.50677493
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.45201980
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33357154
9N-Glycan biosynthesis_Homo sapiens_hsa005102.04157602
10Selenocompound metabolism_Homo sapiens_hsa004501.91481418
11Protein digestion and absorption_Homo sapiens_hsa049741.79959458
12Nucleotide excision repair_Homo sapiens_hsa034201.78394336
13Vitamin B6 metabolism_Homo sapiens_hsa007501.78163079
14Focal adhesion_Homo sapiens_hsa045101.69047770
15Legionellosis_Homo sapiens_hsa051341.68589747
16Mismatch repair_Homo sapiens_hsa034301.63177208
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62520019
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61600443
19DNA replication_Homo sapiens_hsa030301.58240609
20Adherens junction_Homo sapiens_hsa045201.48003739
21One carbon pool by folate_Homo sapiens_hsa006701.46554808
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41149464
23Starch and sucrose metabolism_Homo sapiens_hsa005001.39084985
24TGF-beta signaling pathway_Homo sapiens_hsa043501.38356325
25Biosynthesis of amino acids_Homo sapiens_hsa012301.37515452
26Pyruvate metabolism_Homo sapiens_hsa006201.35161031
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33482125
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32668572
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32144060
30Steroid biosynthesis_Homo sapiens_hsa001001.31924203
31Carbon metabolism_Homo sapiens_hsa012001.29052668
32Small cell lung cancer_Homo sapiens_hsa052221.26653085
33Proteoglycans in cancer_Homo sapiens_hsa052051.25624797
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22350702
35Complement and coagulation cascades_Homo sapiens_hsa046101.13226925
36Basal transcription factors_Homo sapiens_hsa030221.11271520
37Pyrimidine metabolism_Homo sapiens_hsa002401.10682953
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08212249
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.07059360
40Antigen processing and presentation_Homo sapiens_hsa046121.06952604
41Pentose phosphate pathway_Homo sapiens_hsa000301.06557992
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05480840
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04801597
44Thyroid cancer_Homo sapiens_hsa052161.04420378
45Malaria_Homo sapiens_hsa051441.04304224
46Prostate cancer_Homo sapiens_hsa052151.00922855
47RNA polymerase_Homo sapiens_hsa030200.98199685
48Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96930794
49Hippo signaling pathway_Homo sapiens_hsa043900.96854520
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95820523
51MicroRNAs in cancer_Homo sapiens_hsa052060.94509809
52Lysosome_Homo sapiens_hsa041420.94377499
53Tryptophan metabolism_Homo sapiens_hsa003800.93804646
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93201154
55Amoebiasis_Homo sapiens_hsa051460.92909732
56Fatty acid degradation_Homo sapiens_hsa000710.91877787
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90803025
58Galactose metabolism_Homo sapiens_hsa000520.90726286
59Fatty acid elongation_Homo sapiens_hsa000620.90124088
60Cell cycle_Homo sapiens_hsa041100.89309791
61Phagosome_Homo sapiens_hsa041450.88767901
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.87570610
63Bladder cancer_Homo sapiens_hsa052190.87347148
64Ribosome_Homo sapiens_hsa030100.87303312
65p53 signaling pathway_Homo sapiens_hsa041150.85443505
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84133344
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82241275
68Glutathione metabolism_Homo sapiens_hsa004800.81506945
69Folate biosynthesis_Homo sapiens_hsa007900.79909332
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.78202858
71Dilated cardiomyopathy_Homo sapiens_hsa054140.78064905
72Propanoate metabolism_Homo sapiens_hsa006400.77597481
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.77040366
74Homologous recombination_Homo sapiens_hsa034400.76022548
75Renin-angiotensin system_Homo sapiens_hsa046140.75599645
76Fructose and mannose metabolism_Homo sapiens_hsa000510.75340816
77Chronic myeloid leukemia_Homo sapiens_hsa052200.75052073
78Viral myocarditis_Homo sapiens_hsa054160.73067490
79Spliceosome_Homo sapiens_hsa030400.71955285
80Insulin resistance_Homo sapiens_hsa049310.71085431
81Other glycan degradation_Homo sapiens_hsa005110.68819385
82Toxoplasmosis_Homo sapiens_hsa051450.66683822
83Viral carcinogenesis_Homo sapiens_hsa052030.66661454
84Sphingolipid metabolism_Homo sapiens_hsa006000.66638042
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65684310
86Thyroid hormone synthesis_Homo sapiens_hsa049180.65300104
87Caffeine metabolism_Homo sapiens_hsa002320.64635980
88Vibrio cholerae infection_Homo sapiens_hsa051100.63587517
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62849720
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62622236
91RNA degradation_Homo sapiens_hsa030180.62511839
92Hepatitis B_Homo sapiens_hsa051610.61405610
93Leishmaniasis_Homo sapiens_hsa051400.60672899
94Peroxisome_Homo sapiens_hsa041460.60523841
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59913290
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.59717828
97Pancreatic cancer_Homo sapiens_hsa052120.59034065
98Fatty acid metabolism_Homo sapiens_hsa012120.58738223
99TNF signaling pathway_Homo sapiens_hsa046680.57367716
100Lysine degradation_Homo sapiens_hsa003100.57155941
101Fanconi anemia pathway_Homo sapiens_hsa034600.55117905
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54959272
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.54812436
104Chemical carcinogenesis_Homo sapiens_hsa052040.53799023
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53480717
106Pertussis_Homo sapiens_hsa051330.52696574
107HTLV-I infection_Homo sapiens_hsa051660.51867076
108Melanoma_Homo sapiens_hsa052180.50384990
109Apoptosis_Homo sapiens_hsa042100.50247965
110Purine metabolism_Homo sapiens_hsa002300.49728536
111mRNA surveillance pathway_Homo sapiens_hsa030150.49244062
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.48331923
113Tyrosine metabolism_Homo sapiens_hsa003500.47650448
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47469927
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47171372
116Shigellosis_Homo sapiens_hsa051310.46189549
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44983408
118Tight junction_Homo sapiens_hsa045300.44073474
119Arginine and proline metabolism_Homo sapiens_hsa003300.43788046
120Non-homologous end-joining_Homo sapiens_hsa034500.42882877
121Staphylococcus aureus infection_Homo sapiens_hsa051500.42321227
122Endometrial cancer_Homo sapiens_hsa052130.42160366
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41579500
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41186058
125RNA transport_Homo sapiens_hsa030130.40979995
126Basal cell carcinoma_Homo sapiens_hsa052170.40443646
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39504522
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39298016
129Oocyte meiosis_Homo sapiens_hsa041140.37978003
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37745274
131Renal cell carcinoma_Homo sapiens_hsa052110.37264441
132Measles_Homo sapiens_hsa051620.37155509
133Histidine metabolism_Homo sapiens_hsa003400.37004505
134Pathways in cancer_Homo sapiens_hsa052000.36509886
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35379879
136NF-kappa B signaling pathway_Homo sapiens_hsa040640.35108603
137Metabolic pathways_Homo sapiens_hsa011000.34215145
138HIF-1 signaling pathway_Homo sapiens_hsa040660.34110410
139Arginine biosynthesis_Homo sapiens_hsa002200.33487446
140Wnt signaling pathway_Homo sapiens_hsa043100.29537148
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29297761
142Prion diseases_Homo sapiens_hsa050200.28662043
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27919370

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