SSR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)8.28812671
2Golgi transport vesicle coating (GO:0048200)7.65386724
3COPI coating of Golgi vesicle (GO:0048205)7.65386724
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.38131334
5protein retention in ER lumen (GO:0006621)5.94885686
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.50837401
7* cotranslational protein targeting to membrane (GO:0006613)5.43890389
8* protein targeting to ER (GO:0045047)5.42076090
9protein maturation by protein folding (GO:0022417)5.36674886
10GDP-mannose metabolic process (GO:0019673)5.21091927
11* protein localization to endoplasmic reticulum (GO:0070972)5.17953161
12* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.17422539
13COPII vesicle coating (GO:0048208)4.79622279
14ribosomal small subunit assembly (GO:0000028)4.52809067
15cellular ketone body metabolic process (GO:0046950)4.36173151
16exocrine pancreas development (GO:0031017)4.26718894
17sequestering of metal ion (GO:0051238)4.20058623
18positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.17805482
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.06485846
20viral transcription (GO:0019083)4.03554797
21peptide hormone processing (GO:0016486)4.02793698
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93472695
23translational termination (GO:0006415)3.91956658
24endocrine pancreas development (GO:0031018)3.87230931
25ketone body metabolic process (GO:1902224)3.85083446
26ribosomal small subunit biogenesis (GO:0042274)3.82059943
27protein N-linked glycosylation via asparagine (GO:0018279)3.79537626
28DNA deamination (GO:0045006)3.77097533
29regulation of hexokinase activity (GO:1903299)3.76627716
30regulation of glucokinase activity (GO:0033131)3.76627716
31water-soluble vitamin biosynthetic process (GO:0042364)3.76009928
32ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.75502828
33ATP synthesis coupled proton transport (GO:0015986)3.72417248
34energy coupled proton transport, down electrochemical gradient (GO:0015985)3.72417248
35peptidyl-asparagine modification (GO:0018196)3.72278349
36lactate metabolic process (GO:0006089)3.72001918
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65861199
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63413238
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.63413238
40ER overload response (GO:0006983)3.63252942
41positive regulation of respiratory burst (GO:0060267)3.58711947
42L-phenylalanine metabolic process (GO:0006558)3.58530788
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.58530788
44* protein targeting to membrane (GO:0006612)3.58371065
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.57931446
46nucleotide transmembrane transport (GO:1901679)3.57031291
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.54333176
48L-phenylalanine catabolic process (GO:0006559)3.54333176
49* translation (GO:0006412)3.53195178
50protein N-linked glycosylation (GO:0006487)3.50511831
51activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.47969382
52hydrogen ion transmembrane transport (GO:1902600)3.46990979
53regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.44411896
54platelet dense granule organization (GO:0060155)3.44127047
55positive regulation of nuclease activity (GO:0032075)3.39496423
56translational elongation (GO:0006414)3.30775572
57protein neddylation (GO:0045116)3.30144443
58xenobiotic catabolic process (GO:0042178)3.29890320
59dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.26599385
60regulation of type B pancreatic cell apoptotic process (GO:2000674)3.23291612
61proton transport (GO:0015992)3.21917256
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21832128
63respiratory electron transport chain (GO:0022904)3.20311301
64inositol phosphate catabolic process (GO:0071545)3.19626376
65C-terminal protein lipidation (GO:0006501)3.19357268
66insulin secretion (GO:0030073)3.18563826
67glycerophospholipid catabolic process (GO:0046475)3.18197236
68hydrogen transport (GO:0006818)3.16558500
69viral life cycle (GO:0019058)3.16396522
70ER to Golgi vesicle-mediated transport (GO:0006888)3.15807253
71electron transport chain (GO:0022900)3.15275050
72positive regulation of peptide hormone secretion (GO:0090277)3.14923492
73regulation of nuclease activity (GO:0032069)3.13445961
74endoplasmic reticulum unfolded protein response (GO:0030968)3.13103630
75regulation of mitochondrial translation (GO:0070129)3.12457903
76antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.12222184
77phosphorylated carbohydrate dephosphorylation (GO:0046838)3.11387904
78inositol phosphate dephosphorylation (GO:0046855)3.11387904
79cellular response to unfolded protein (GO:0034620)3.08951369
80cellular response to topologically incorrect protein (GO:0035967)3.08203286
81negative regulation of execution phase of apoptosis (GO:1900118)3.07802380
82glandular epithelial cell differentiation (GO:0002067)3.07258569
83cell redox homeostasis (GO:0045454)3.07125944
84nitric oxide biosynthetic process (GO:0006809)3.05336737
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.03226843
86nucleotide-sugar biosynthetic process (GO:0009226)3.02813314
87positive regulation of glycolytic process (GO:0045821)3.01840186
88nucleoside diphosphate catabolic process (GO:0009134)3.01661176
89mannosylation (GO:0097502)3.01295896
90negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.01235586
91respiratory chain complex IV assembly (GO:0008535)3.00717945
92positive regulation of peptide secretion (GO:0002793)2.99429890
93pteridine-containing compound biosynthetic process (GO:0042559)2.98536700
94intestinal cholesterol absorption (GO:0030299)2.97463119
95regulation of autophagic vacuole assembly (GO:2000785)2.97026598
96nucleotide-sugar metabolic process (GO:0009225)2.94829029
97L-alpha-amino acid transmembrane transport (GO:1902475)2.94137757
98positive regulation of calcium ion import (GO:0090280)2.94101641
99protein complex biogenesis (GO:0070271)2.92787059
100peptidyl-histidine modification (GO:0018202)2.91173467
101eosinophil chemotaxis (GO:0048245)2.91157863
102regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.91140135
103proline biosynthetic process (GO:0006561)2.89793423
104protein autoprocessing (GO:0016540)2.89187250
105cellular protein complex disassembly (GO:0043624)2.88354744
106UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85482382
107ER-nucleus signaling pathway (GO:0006984)2.84933057
108ATP hydrolysis coupled proton transport (GO:0015991)2.84222547
109energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.84222547
110translational initiation (GO:0006413)2.82060973
111nitric oxide mediated signal transduction (GO:0007263)2.81649430
112mitochondrial calcium ion transport (GO:0006851)2.81426460
113positive regulation of insulin secretion (GO:0032024)2.80552172
114C-terminal protein amino acid modification (GO:0018410)2.80384878
115vesicle coating (GO:0006901)2.79359712
116cytochrome complex assembly (GO:0017004)2.79249641
117response to endoplasmic reticulum stress (GO:0034976)2.79033868
118positive regulation of TOR signaling (GO:0032008)2.77462089
119purine nucleoside triphosphate biosynthetic process (GO:0009145)2.75621332
120epithelial cell fate commitment (GO:0072148)2.73634186
121preassembly of GPI anchor in ER membrane (GO:0016254)2.73489692
122peptide metabolic process (GO:0006518)2.72669680
123L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72519792
124purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72351029
125ATP biosynthetic process (GO:0006754)2.71309979
126auditory receptor cell differentiation (GO:0042491)2.70973033
127digestion (GO:0007586)2.70487203
128nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.69785089
129glucosamine-containing compound catabolic process (GO:1901072)2.68007785
130regulation of oxidative phosphorylation (GO:0002082)2.67316324
131fucose metabolic process (GO:0006004)2.66832964
132regulation of cellular amino acid metabolic process (GO:0006521)2.63535694
133guanosine-containing compound biosynthetic process (GO:1901070)2.62190997
134eosinophil migration (GO:0072677)2.62165381
135negative regulation of glycoprotein biosynthetic process (GO:0010561)2.60993624
136mitochondrial respiratory chain complex assembly (GO:0033108)2.60706995
137regulation of vacuole organization (GO:0044088)2.58725843
138* establishment of protein localization to membrane (GO:0090150)2.56993352
139GPI anchor biosynthetic process (GO:0006506)2.56991486
140deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56801329
141proteasome assembly (GO:0043248)2.56448710
142pyrimidine-containing compound transmembrane transport (GO:0072531)2.55711697
143* protein targeting (GO:0006605)2.55554535
144regulation of insulin secretion (GO:0050796)2.55442502
145polyol catabolic process (GO:0046174)2.54574247
146zinc ion homeostasis (GO:0055069)2.53831741
147phenylpropanoid metabolic process (GO:0009698)2.50876945
148hydrogen peroxide catabolic process (GO:0042744)2.50362827
149glycolipid catabolic process (GO:0019377)2.48192402
150positive regulation of prostaglandin secretion (GO:0032308)2.47811958
151response to unfolded protein (GO:0006986)2.47451412
152negative regulation of acute inflammatory response (GO:0002674)2.46214059
153response to topologically incorrect protein (GO:0035966)2.45627365
154reactive oxygen species biosynthetic process (GO:1903409)2.45044485
155iron-sulfur cluster assembly (GO:0016226)2.44270117
156metallo-sulfur cluster assembly (GO:0031163)2.44270117
157chaperone-mediated protein transport (GO:0072321)2.43509758
158toxin metabolic process (GO:0009404)2.43180394
159peptide catabolic process (GO:0043171)2.43170210
160tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42390023
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42390023
162regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.42332504
163glutathione derivative metabolic process (GO:1901685)2.42062810
164glutathione derivative biosynthetic process (GO:1901687)2.42062810
165GTP biosynthetic process (GO:0006183)2.40357160
166protein peptidyl-prolyl isomerization (GO:0000413)2.40098162
167axoneme assembly (GO:0035082)2.39385531
168type B pancreatic cell development (GO:0003323)2.39134368
169positive regulation of hormone secretion (GO:0046887)2.39026461
170NADH dehydrogenase complex assembly (GO:0010257)2.38875077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.49614277
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.39144650
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25459495
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.91368786
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61144824
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.46392506
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.40197062
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.27061948
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26449316
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.01575046
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75957955
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70507365
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.59242334
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58668927
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.57053669
16GATA1_22025678_ChIP-Seq_K562_Human2.39419502
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35797320
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33270725
19VDR_23849224_ChIP-Seq_CD4+_Human2.31388002
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.30923972
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.28915659
22DCP1A_22483619_ChIP-Seq_HELA_Human2.23044032
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.21155522
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16683679
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15888646
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.15374611
27ERG_20887958_ChIP-Seq_HPC-7_Mouse2.13818350
28* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12954999
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04598832
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.04517257
31ELK1_19687146_ChIP-ChIP_HELA_Human1.99626542
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.97910045
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96713011
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91353363
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90271546
36GABP_19822575_ChIP-Seq_HepG2_Human1.85405564
37HTT_18923047_ChIP-ChIP_STHdh_Human1.80354975
38FOXP3_21729870_ChIP-Seq_TREG_Human1.79526390
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78451872
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.77249109
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76094700
42* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.69044742
43* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67012011
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.64755209
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61712210
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58098459
47ZNF274_21170338_ChIP-Seq_K562_Hela1.57218377
48XRN2_22483619_ChIP-Seq_HELA_Human1.54227821
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54026171
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.50035775
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50035775
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.49677685
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49092239
54TP53_22573176_ChIP-Seq_HFKS_Human1.48246199
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43600118
56TFEB_21752829_ChIP-Seq_HELA_Human1.42686169
57SPI1_23547873_ChIP-Seq_NB4_Human1.36181569
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33339211
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31724155
60TTF2_22483619_ChIP-Seq_HELA_Human1.31668270
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31414863
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30280774
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28934857
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27952480
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27484456
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27272619
67* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26721739
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23619188
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23358280
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22421536
71MYC_18940864_ChIP-ChIP_HL60_Human1.20466497
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.18545583
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.18341863
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13284306
75TAF2_19829295_ChIP-Seq_ESCs_Human1.12839657
76NCOR_22424771_ChIP-Seq_293T_Human1.12620648
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10551660
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09842318
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08058526
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07873520
81MYC_19829295_ChIP-Seq_ESCs_Human1.05225882
82STAT1_20625510_ChIP-Seq_HELA_Human1.04838475
83SOX2_19829295_ChIP-Seq_ESCs_Human1.04648986
84NANOG_19829295_ChIP-Seq_ESCs_Human1.04648986
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.04608242
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.03389268
87BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02738763
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01544384
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01519298
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01259404
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00834325
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99424480
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99363819
94ERA_21632823_ChIP-Seq_H3396_Human0.99255807
95ERG_20517297_ChIP-Seq_VCAP_Human0.98972517
96RXR_22158963_ChIP-Seq_LIVER_Mouse0.98494462
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96684788
98BCAT_22108803_ChIP-Seq_LS180_Human0.96043263
99NANOG_20526341_ChIP-Seq_ESCs_Human0.95493958
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95423420
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94863900
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94585974
103FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94340693
104VDR_22108803_ChIP-Seq_LS180_Human0.94266937
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94075753
106CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93473535
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93269587
108SOX2_20726797_ChIP-Seq_SW620_Human0.93164157
109* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92067829
110AR_20517297_ChIP-Seq_VCAP_Human0.91824625
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91608671
112EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88647022
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88009003
114P300_27268052_Chip-Seq_Bcells_Human0.87846668
115RBPJ_21746931_ChIP-Seq_IB4_Human0.87666971
116EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87385903
117BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86509189
118LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86106662
119PHF8_20622853_ChIP-Seq_HELA_Human0.85878090
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85620060
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85195078
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84806557
123MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84763417
124IRF1_19129219_ChIP-ChIP_H3396_Human0.84663497
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84312669
126KDM5A_27292631_Chip-Seq_BREAST_Human0.84237868
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83865116
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82188711
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82130435
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82111031
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81781239
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81674368
133GATA6_21074721_ChIP-Seq_CACO-2_Human0.80966577
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80627742
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.80485562
136RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80387215
137CIITA_25753668_ChIP-Seq_RAJI_Human0.80327802
138HOXB7_26014856_ChIP-Seq_BT474_Human0.80297128
139FOXH1_21741376_ChIP-Seq_EPCs_Human0.80180525
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79946749
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.79762481
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78964448
143* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.78904700
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78745243
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78712927
146PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78594007
147CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.78426863
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77953773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.02470325
2MP0003183_abnormal_peptide_metabolism3.79073488
3MP0005220_abnormal_exocrine_pancreas3.57772897
4MP0005379_endocrine/exocrine_gland_phen3.53882983
5MP0002693_abnormal_pancreas_physiology3.32011033
6MP0004043_abnormal_pH_regulation3.14339407
7MP0010386_abnormal_urinary_bladder2.95966896
8MP0000013_abnormal_adipose_tissue2.90670876
9MP0001944_abnormal_pancreas_morphology2.83851608
10MP0010234_abnormal_vibrissa_follicle2.65628285
11MP0002877_abnormal_melanocyte_morpholog2.56607277
12MP0005083_abnormal_biliary_tract2.55181759
13MP0005058_abnormal_lysosome_morphology2.54967172
14MP0001666_abnormal_nutrient_absorption2.36675636
15MP0003787_abnormal_imprinting2.34496223
16MP0005365_abnormal_bile_salt2.18968181
17MP0002163_abnormal_gland_morphology2.14915629
18MP0005084_abnormal_gallbladder_morpholo2.10162032
19MP0000372_irregular_coat_pigmentation2.09680247
20MP0009379_abnormal_foot_pigmentation2.09616179
21MP0001986_abnormal_taste_sensitivity2.06186587
22MP0004019_abnormal_vitamin_homeostasis1.95405147
23MP0005646_abnormal_pituitary_gland1.88715430
24MP0005636_abnormal_mineral_homeostasis1.86215224
25MP0006054_spinal_hemorrhage1.85544392
26MP0003724_increased_susceptibility_to1.81808647
27MP0003186_abnormal_redox_activity1.80647373
28MP0002909_abnormal_adrenal_gland1.77971403
29MP0004264_abnormal_extraembryonic_tissu1.77414360
30MP0002254_reproductive_system_inflammat1.75900260
31MP0003806_abnormal_nucleotide_metabolis1.74865720
32MP0009643_abnormal_urine_homeostasis1.71476518
33MP0002876_abnormal_thyroid_physiology1.70942884
34MP0003868_abnormal_feces_composition1.70851963
35MP0003011_delayed_dark_adaptation1.67208633
36MP0003123_paternal_imprinting1.63844080
37MP0002638_abnormal_pupillary_reflex1.63628910
38MP0002148_abnormal_hypersensitivity_rea1.63339232
39MP0005645_abnormal_hypothalamus_physiol1.61263342
40MP0002078_abnormal_glucose_homeostasis1.58713173
41MP0001905_abnormal_dopamine_level1.56691259
42MP0000678_abnormal_parathyroid_gland1.55596942
43MP0002837_dystrophic_cardiac_calcinosis1.53631066
44MP0005408_hypopigmentation1.52001569
45MP0001764_abnormal_homeostasis1.51956217
46MP0001835_abnormal_antigen_presentation1.48746482
47MP0003959_abnormal_lean_body1.48732931
48MP0003122_maternal_imprinting1.48215750
49MP0008877_abnormal_DNA_methylation1.48200483
50MP0005310_abnormal_salivary_gland1.48099921
51MP0006036_abnormal_mitochondrial_physio1.47290333
52MP0002277_abnormal_respiratory_mucosa1.46598770
53MP0010329_abnormal_lipoprotein_level1.46017809
54MP0000613_abnormal_salivary_gland1.45632064
55MP0003436_decreased_susceptibility_to1.45574079
56MP0001765_abnormal_ion_homeostasis1.42568904
57MP0000003_abnormal_adipose_tissue1.41884409
58MP0002139_abnormal_hepatobiliary_system1.41003334
59MP0003786_premature_aging1.38734705
60MP0003693_abnormal_embryo_hatching1.38573406
61MP0009785_altered_susceptibility_to1.38491200
62MP0008875_abnormal_xenobiotic_pharmacok1.35142151
63MP0009046_muscle_twitch1.32837819
64MP0005000_abnormal_immune_tolerance1.26580987
65MP0003172_abnormal_lysosome_physiology1.26501006
66MP0001756_abnormal_urination1.25448396
67MP0005551_abnormal_eye_electrophysiolog1.22627365
68MP0005671_abnormal_response_to1.22621333
69MP0000681_abnormal_thyroid_gland1.19844841
70MP0008872_abnormal_physiological_respon1.19699338
71MP0003866_abnormal_defecation1.18624960
72MP0002419_abnormal_innate_immunity1.17554530
73MP0001845_abnormal_inflammatory_respons1.17345439
74MP0005253_abnormal_eye_physiology1.16008022
75MP0006072_abnormal_retinal_apoptosis1.15374079
76MP0005025_abnormal_response_to1.15124468
77MP0008469_abnormal_protein_level1.14695072
78MP0003283_abnormal_digestive_organ1.14200242
79MP0005174_abnormal_tail_pigmentation1.13892604
80MP0009333_abnormal_splenocyte_physiolog1.10074285
81MP0005387_immune_system_phenotype1.08909022
82MP0001790_abnormal_immune_system1.08909022
83MP0001533_abnormal_skeleton_physiology1.08577672
84MP0000015_abnormal_ear_pigmentation1.06896929
85MP0002090_abnormal_vision1.05094973
86MP0005085_abnormal_gallbladder_physiolo1.01515986
87MP0005075_abnormal_melanosome_morpholog1.00603777
88MP0001664_abnormal_digestion0.99863411
89MP0003953_abnormal_hormone_level0.99834280
90MP0005389_reproductive_system_phenotype0.98893456
91MP0008995_early_reproductive_senescence0.98677171
92MP0002138_abnormal_hepatobiliary_system0.98542799
93MP0002938_white_spotting0.97717558
94MP0002295_abnormal_pulmonary_circulatio0.96353344
95MP0002933_joint_inflammation0.95208625
96MP0005332_abnormal_amino_acid0.95194808
97MP0001501_abnormal_sleep_pattern0.94443389
98MP0003795_abnormal_bone_structure0.93669401
99MP0001542_abnormal_bone_strength0.93377087
100MP0009780_abnormal_chondrocyte_physiolo0.92186822
101MP0005367_renal/urinary_system_phenotyp0.91991485
102MP0000516_abnormal_urinary_system0.91991485
103MP0000631_abnormal_neuroendocrine_gland0.91259281
104MP0004133_heterotaxia0.91250022
105MP0004142_abnormal_muscle_tone0.90998658
106MP0002723_abnormal_immune_serum0.90827550
107MP0001881_abnormal_mammary_gland0.89975744
108MP0001919_abnormal_reproductive_system0.88449181
109MP0005535_abnormal_body_temperature0.87603446
110MP0003656_abnormal_erythrocyte_physiolo0.84741087
111MP0005410_abnormal_fertilization0.83755259
112MP0004782_abnormal_surfactant_physiolog0.83536295
113MP0001984_abnormal_olfaction0.82118532
114MP0001661_extended_life_span0.81925672
115MP0000538_abnormal_urinary_bladder0.81391199
116MP0009840_abnormal_foam_cell0.80450113
117MP0009642_abnormal_blood_homeostasis0.78717192
118MP0002160_abnormal_reproductive_system0.78693420
119MP0002118_abnormal_lipid_homeostasis0.78625270
120MP0000685_abnormal_immune_system0.78385959
121MP0002166_altered_tumor_susceptibility0.78030436
122MP0002420_abnormal_adaptive_immunity0.76939948
123MP0000230_abnormal_systemic_arterial0.76178924
124MP0006035_abnormal_mitochondrial_morpho0.76067900
125MP0003300_gastrointestinal_ulcer0.75441922
126MP0001819_abnormal_immune_cell0.75424779
127MP0002896_abnormal_bone_mineralization0.74640503
128MP0003075_altered_response_to0.74137623
129MP0005464_abnormal_platelet_physiology0.73171823
130MP0005448_abnormal_energy_balance0.72293635
131MP0000358_abnormal_cell_content/0.71919149
132MP0004147_increased_porphyrin_level0.71916461
133MP0002452_abnormal_antigen_presenting0.71525847
134MP0000609_abnormal_liver_physiology0.71497202
135MP0002822_catalepsy0.71288106
136MP0005319_abnormal_enzyme/_coenzyme0.71154172
137MP0002928_abnormal_bile_duct0.70943534
138MP0000490_abnormal_crypts_of0.70663439
139MP0006082_CNS_inflammation0.69270497
140MP0000639_abnormal_adrenal_gland0.68406885
141MP0002136_abnormal_kidney_physiology0.67779357
142MP0009745_abnormal_behavioral_response0.66410394
143MP0000427_abnormal_hair_cycle0.63988225
144MP0002557_abnormal_social/conspecific_i0.63647198
145MP0003121_genomic_imprinting0.63624404
146MP0002095_abnormal_skin_pigmentation0.63468897
147MP0001970_abnormal_pain_threshold0.62222129
148MP0002229_neurodegeneration0.61134969

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)4.37680428
2Abnormal protein N-linked glycosylation (HP:0012347)4.19866437
3Abnormal protein glycosylation (HP:0012346)4.19866437
4Abnormal glycosylation (HP:0012345)4.19866437
5Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.19866437
6Vacuolated lymphocytes (HP:0001922)4.09124783
7Hypoglycemic coma (HP:0001325)4.07006428
8Hypoglycemic seizures (HP:0002173)3.97292079
9Symptomatic seizures (HP:0011145)3.92195962
10Hyperinsulinemic hypoglycemia (HP:0000825)3.88499988
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.65183240
12Reduced antithrombin III activity (HP:0001976)3.62864219
13Abnormality of cells of the erythroid lineage (HP:0012130)3.59991508
14Acute necrotizing encephalopathy (HP:0006965)3.57607427
15Abnormality of the intrinsic pathway (HP:0010989)3.46821111
16Abnormal number of erythroid precursors (HP:0012131)3.42330759
17Dysostosis multiplex (HP:0000943)3.39097714
18Mitochondrial inheritance (HP:0001427)3.31912836
19Generalized aminoaciduria (HP:0002909)3.31491393
20Abnormal mitochondria in muscle tissue (HP:0008316)3.27590725
21Hepatic necrosis (HP:0002605)3.21274465
22Acute encephalopathy (HP:0006846)3.13769939
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.00369325
24Hepatocellular necrosis (HP:0001404)2.85227654
25Renal Fanconi syndrome (HP:0001994)2.84984332
26Lipid accumulation in hepatocytes (HP:0006561)2.78031021
27Abnormality of vitamin B metabolism (HP:0004340)2.77653678
28Increased hepatocellular lipid droplets (HP:0006565)2.76039646
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75230226
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75230226
31Hypothermia (HP:0002045)2.73582744
32Increased CSF lactate (HP:0002490)2.73031506
33Progressive macrocephaly (HP:0004481)2.72936924
34Beaking of vertebral bodies (HP:0004568)2.71748844
35Urinary glycosaminoglycan excretion (HP:0003541)2.69415267
36Mucopolysacchariduria (HP:0008155)2.69415267
37Hypokinesia (HP:0002375)2.68825969
38Double outlet right ventricle (HP:0001719)2.67405147
39Congenital malformation of the right heart (HP:0011723)2.67405147
40Late onset (HP:0003584)2.64365177
41Progressive neurologic deterioration (HP:0002344)2.59376362
42Abnormality of calcium-phosphate metabolism (HP:0100530)2.56851571
43Abnormality of the pancreatic islet cells (HP:0006476)2.56293927
44Abnormality of endocrine pancreas physiology (HP:0012093)2.56293927
45Aplastic anemia (HP:0001915)2.54615415
46Methylmalonic aciduria (HP:0012120)2.51921272
47Ketoacidosis (HP:0001993)2.50588768
48Methylmalonic acidemia (HP:0002912)2.47597061
49Hyperthyroidism (HP:0000836)2.47277560
503-Methylglutaconic aciduria (HP:0003535)2.43867827
51Glycosuria (HP:0003076)2.43293553
52Abnormality of urine glucose concentration (HP:0011016)2.43293553
53Hyperglycemia (HP:0003074)2.43069147
54Agitation (HP:0000713)2.40486455
55Hypomagnesemia (HP:0002917)2.36689788
56Large for gestational age (HP:0001520)2.35803573
57Abnormality of polysaccharide metabolism (HP:0011012)2.33637306
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33637306
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33637306
60Abnormality of renal resorption (HP:0011038)2.33260473
61Exertional dyspnea (HP:0002875)2.31204783
62Hypoalbuminemia (HP:0003073)2.30596345
63Abnormal albumin level (HP:0012116)2.30596345
64Thrombocytosis (HP:0001894)2.30086981
65Irregular vertebral endplates (HP:0003301)2.28473205
66Abnormality of magnesium homeostasis (HP:0004921)2.27407152
67Enlarged penis (HP:0000040)2.25099305
68Hyperphosphaturia (HP:0003109)2.24355191
69Poor head control (HP:0002421)2.23611058
70Lethargy (HP:0001254)2.22589288
71Reticulocytopenia (HP:0001896)2.20795622
72Conjunctival hamartoma (HP:0100780)2.20760256
73Insulin-resistant diabetes mellitus (HP:0000831)2.19621756
74Conjugated hyperbilirubinemia (HP:0002908)2.18364968
75Increased intramyocellular lipid droplets (HP:0012240)2.18285501
76Tongue fasciculations (HP:0001308)2.16899344
77Abnormality of liposaccharide metabolism (HP:0010968)2.13604030
78Abnormality of glycosphingolipid metabolism (HP:0004343)2.13604030
79Abnormality of glycolipid metabolism (HP:0010969)2.13604030
80Petechiae (HP:0000967)2.12063743
81Abnormality of vitamin metabolism (HP:0100508)2.11772376
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10438467
83Macrocytic anemia (HP:0001972)2.09273258
84Increased muscle lipid content (HP:0009058)2.09226169
85Abnormal tarsal ossification (HP:0008369)2.08596053
86Abnormal pancreas size (HP:0012094)2.08582500
87Optic disc pallor (HP:0000543)2.08453240
88Cerebral edema (HP:0002181)2.08127385
89Pallor (HP:0000980)2.05970173
90Increased CSF protein (HP:0002922)2.05205894
91Abnormality of the common coagulation pathway (HP:0010990)2.04582917
92Lactic acidosis (HP:0003128)2.04137582
93Flat capital femoral epiphysis (HP:0003370)2.02599770
94Testicular atrophy (HP:0000029)2.02113898
95Hyperparathyroidism (HP:0000843)2.01967924
96Pancreatic fibrosis (HP:0100732)2.00958474
97Pancreatic islet-cell hyperplasia (HP:0004510)1.99345118
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98525424
99Prolonged neonatal jaundice (HP:0006579)1.98269643
100Prolonged partial thromboplastin time (HP:0003645)1.98114120
101Pancreatic cysts (HP:0001737)1.96423318
102Intestinal atresia (HP:0011100)1.94915380
103Medial flaring of the eyebrow (HP:0010747)1.94494514
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94093072
105Dysautonomia (HP:0002459)1.90670563
106Abdominal distention (HP:0003270)1.90214213
10711 pairs of ribs (HP:0000878)1.89839379
108Abnormality of the vertebral endplates (HP:0005106)1.89238697
109Muscular hypotonia of the trunk (HP:0008936)1.88715589
110Retinal atrophy (HP:0001105)1.88077619
111Poor suck (HP:0002033)1.87809810
112Abnormality of midbrain morphology (HP:0002418)1.87715786
113Molar tooth sign on MRI (HP:0002419)1.87715786
114Respiratory failure (HP:0002878)1.86863400
115Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86538815
116Exercise intolerance (HP:0003546)1.86410977
117Abnormality of the renal cortex (HP:0011035)1.86090661
118Microvesicular hepatic steatosis (HP:0001414)1.83849593
119Thoracolumbar scoliosis (HP:0002944)1.83359487
120Ketosis (HP:0001946)1.83300030
121Vascular calcification (HP:0004934)1.81738074
122Increased serum lactate (HP:0002151)1.81356418
123Albinism (HP:0001022)1.81099252
124Abnormal drinking behavior (HP:0030082)1.80343465
125Polydipsia (HP:0001959)1.80343465
126Hemiparesis (HP:0001269)1.79909405
127Aplasia/hypoplasia of the uterus (HP:0008684)1.79783675
128Abnormal rod and cone electroretinograms (HP:0008323)1.79343033
129Joint stiffness (HP:0001387)1.78943736
130Abnormality of the pons (HP:0007361)1.77948944
131Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77164633
132Dicarboxylic aciduria (HP:0003215)1.77164633
133Hypoplasia of the pons (HP:0012110)1.76979414
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75462667
135Hyperphosphatemia (HP:0002905)1.75166846
136Congenital sensorineural hearing impairment (HP:0008527)1.74947587
137Abnormality of T cell physiology (HP:0011840)1.74461913
138Decreased circulating renin level (HP:0003351)1.74334400
139Abnormal pupillary function (HP:0007686)1.73490606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.18032463
2NME23.91199505
3ERN13.64271708
4EIF2AK33.41282261
5INSRR3.30593088
6STK163.23875798
7BCKDK3.20679374
8IRAK32.97811372
9PIK3CG2.97017139
10VRK22.92229481
11PASK2.90456107
12TAOK32.84173270
13MAP4K22.79781158
14FGFR22.60148324
15GRK12.41869587
16PHKG12.26011582
17PHKG22.26011582
18WNK42.23933424
19FLT32.18070541
20WNK32.12694458
21IRAK42.11320917
22PIM21.93080068
23MAP2K61.91299616
24CAMKK21.79832791
25NME11.78342558
26VRK11.68955604
27MST41.66907504
28PAK31.64138333
29TEC1.53163888
30ZAK1.44859859
31HIPK21.42167853
32FRK1.41093613
33BRSK21.31988954
34DAPK21.31382407
35ARAF1.30546753
36BRAF1.30390666
37FER1.29931175
38MAP2K21.28593781
39IRAK11.22367689
40PINK11.15834551
41ZAP701.14274588
42TBK11.12309086
43MAP3K31.10416133
44CSNK1G31.09121516
45CSNK1G11.07873504
46MAPKAPK31.06090694
47ADRBK21.03500539
48EIF2AK11.03170821
49TRIM281.02331950
50SCYL21.00584182
51BTK0.95472359
52PRKCE0.94075645
53ILK0.91272161
54TYK20.89062453
55TNK20.87784625
56AKT30.87394425
57MAP3K20.84897178
58JAK30.84685334
59STK40.84602496
60DAPK10.81031000
61FGFR30.81015606
62STK30.80110700
63DAPK30.79241160
64TNIK0.78750198
65MYLK0.77058383
66EPHA20.76779467
67CSNK1G20.76417669
68IKBKB0.75531438
69BMPR1B0.74602632
70TESK10.74420231
71STK240.74031736
72MAP3K140.73670821
73GRK70.73523459
74NLK0.73310440
75NTRK30.71253432
76MAPKAPK50.71009844
77UHMK10.70271338
78TRPM70.70059697
79BMPR20.69919163
80PRKCG0.69184276
81PBK0.68648119
82OXSR10.68157568
83DYRK30.67759736
84STK390.67563637
85KDR0.65704517
86LYN0.64667313
87CDK80.63005135
88SYK0.62376869
89IKBKE0.61789240
90PRKCI0.60961858
91ACVR1B0.60730991
92ABL20.57824656
93MAP3K120.57236434
94PRKG20.56162726
95MET0.55252927
96IRAK20.54889157
97BLK0.52821610
98TLK10.51875283
99CSNK1A1L0.51235027
100RPS6KB20.50787457
101BUB10.49845162
102RPS6KA50.49809998
103DYRK1B0.48956439
104MST1R0.47977691
105MAP3K10.47388400
106CSNK1A10.47184959
107CHUK0.46754864
108EIF2AK20.45368373
109NTRK10.44374075
110MAP4K10.43991404
111ITK0.43095554
112CSK0.42625825
113PRKCQ0.42050073
114KIT0.41877430
115MAP3K40.41830603
116NUAK10.41194456
117MUSK0.40972785
118GSK3A0.39887401
119PLK20.39650140
120DYRK20.39534486
121LRRK20.38819356
122CASK0.38483423
123MAP2K30.38388113
124TESK20.37344376
125TXK0.37242150
126PTK2B0.36642645
127CSNK2A10.36484281
128PRKCA0.36393817
129PRKACA0.35141585
130PLK30.35059622
131PRKCD0.33760711
132LMTK20.33406078
133GRK50.33005241
134EPHA30.32807675
135RPS6KA40.32789307
136TAOK10.32123358
137CSNK2A20.31738680
138MAP2K70.31645203
139MAP3K90.31587788
140LCK0.30622723
141CDK190.28992758
142JAK20.28010902
143CAMK2D0.26799655
144ADRBK10.26309324
145MAPKAPK20.25932433
146WEE10.25682706
147MAP3K110.23894690
148SRPK10.23800075
149LIMK10.21221429

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.38455085
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.19219533
3Ribosome_Homo sapiens_hsa030103.48939135
4Oxidative phosphorylation_Homo sapiens_hsa001902.96005131
5* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.76272817
6Folate biosynthesis_Homo sapiens_hsa007902.72906532
7Sulfur metabolism_Homo sapiens_hsa009202.60123405
8Proteasome_Homo sapiens_hsa030502.47410229
9Other glycan degradation_Homo sapiens_hsa005112.26292882
10Parkinsons disease_Homo sapiens_hsa050122.24607606
11N-Glycan biosynthesis_Homo sapiens_hsa005102.24399581
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20904617
13Butanoate metabolism_Homo sapiens_hsa006502.07452336
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.99697340
15Vibrio cholerae infection_Homo sapiens_hsa051101.95540040
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.88074254
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78098103
18Alzheimers disease_Homo sapiens_hsa050101.74433024
19Cardiac muscle contraction_Homo sapiens_hsa042601.48246988
20RNA polymerase_Homo sapiens_hsa030201.43966203
21Huntingtons disease_Homo sapiens_hsa050161.43804702
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42489119
23Lysosome_Homo sapiens_hsa041421.40992187
24Vitamin B6 metabolism_Homo sapiens_hsa007501.38955194
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32400854
26Type I diabetes mellitus_Homo sapiens_hsa049401.17915920
27Pyrimidine metabolism_Homo sapiens_hsa002401.17504193
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.17021879
29Sulfur relay system_Homo sapiens_hsa041221.08882244
30Regulation of autophagy_Homo sapiens_hsa041401.07763275
31Pancreatic secretion_Homo sapiens_hsa049721.06180528
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04543600
33Mineral absorption_Homo sapiens_hsa049781.02321419
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00943285
35Galactose metabolism_Homo sapiens_hsa000521.00037094
36Histidine metabolism_Homo sapiens_hsa003400.97017852
37Selenocompound metabolism_Homo sapiens_hsa004500.96759304
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95236873
39Phototransduction_Homo sapiens_hsa047440.93805992
40Fatty acid elongation_Homo sapiens_hsa000620.93800820
41Fat digestion and absorption_Homo sapiens_hsa049750.92505813
42Sphingolipid metabolism_Homo sapiens_hsa006000.92283346
43Propanoate metabolism_Homo sapiens_hsa006400.91341361
44Linoleic acid metabolism_Homo sapiens_hsa005910.89611127
45Legionellosis_Homo sapiens_hsa051340.88201581
46Arachidonic acid metabolism_Homo sapiens_hsa005900.84825580
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84144006
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83214062
49Collecting duct acid secretion_Homo sapiens_hsa049660.83115085
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.81946634
51Steroid biosynthesis_Homo sapiens_hsa001000.81607322
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81344316
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80842818
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80351452
55Antigen processing and presentation_Homo sapiens_hsa046120.78071894
56Metabolic pathways_Homo sapiens_hsa011000.77174608
57Renin-angiotensin system_Homo sapiens_hsa046140.74968962
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.72947279
59Protein digestion and absorption_Homo sapiens_hsa049740.72591917
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72325356
61Synaptic vesicle cycle_Homo sapiens_hsa047210.71588576
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70707190
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67716057
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67289399
65Nitrogen metabolism_Homo sapiens_hsa009100.65730606
66Rheumatoid arthritis_Homo sapiens_hsa053230.65446770
67Homologous recombination_Homo sapiens_hsa034400.64970574
68Glutathione metabolism_Homo sapiens_hsa004800.64955035
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63854747
70Phagosome_Homo sapiens_hsa041450.62987783
71Peroxisome_Homo sapiens_hsa041460.62932198
72Fatty acid metabolism_Homo sapiens_hsa012120.62425934
73beta-Alanine metabolism_Homo sapiens_hsa004100.60023532
74Insulin secretion_Homo sapiens_hsa049110.59506818
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58531700
76Fatty acid degradation_Homo sapiens_hsa000710.55874839
77Retinol metabolism_Homo sapiens_hsa008300.55495312
78Purine metabolism_Homo sapiens_hsa002300.54674829
79Tryptophan metabolism_Homo sapiens_hsa003800.52365669
80Asthma_Homo sapiens_hsa053100.51493690
81Arginine and proline metabolism_Homo sapiens_hsa003300.51483169
82Phenylalanine metabolism_Homo sapiens_hsa003600.51343649
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50181389
84Starch and sucrose metabolism_Homo sapiens_hsa005000.49832588
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49659892
86DNA replication_Homo sapiens_hsa030300.49442366
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48920777
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.48580494
89Circadian rhythm_Homo sapiens_hsa047100.46694362
90Tyrosine metabolism_Homo sapiens_hsa003500.46033231
91Nucleotide excision repair_Homo sapiens_hsa034200.42554259
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41694719
93Fructose and mannose metabolism_Homo sapiens_hsa000510.41136015
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40457395
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38750260
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36148230
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.35706051
98Basal transcription factors_Homo sapiens_hsa030220.35630721
99Graft-versus-host disease_Homo sapiens_hsa053320.34667609
100ABC transporters_Homo sapiens_hsa020100.33938932
101Ether lipid metabolism_Homo sapiens_hsa005650.33642199
102Arginine biosynthesis_Homo sapiens_hsa002200.33494052
103Mismatch repair_Homo sapiens_hsa034300.33006116
104Pentose phosphate pathway_Homo sapiens_hsa000300.32570548
105RNA degradation_Homo sapiens_hsa030180.31365258
106Non-homologous end-joining_Homo sapiens_hsa034500.30895785
107Autoimmune thyroid disease_Homo sapiens_hsa053200.30677397
108Prion diseases_Homo sapiens_hsa050200.29449380
109Hematopoietic cell lineage_Homo sapiens_hsa046400.29382986
110One carbon pool by folate_Homo sapiens_hsa006700.29372460
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28422125
112Caffeine metabolism_Homo sapiens_hsa002320.28320328
113Pertussis_Homo sapiens_hsa051330.27852695
114Chemical carcinogenesis_Homo sapiens_hsa052040.26327332
115Vitamin digestion and absorption_Homo sapiens_hsa049770.26313371
116Allograft rejection_Homo sapiens_hsa053300.25363762
117Spliceosome_Homo sapiens_hsa030400.25262154
118Ovarian steroidogenesis_Homo sapiens_hsa049130.25216252
119Base excision repair_Homo sapiens_hsa034100.25066644
120Type II diabetes mellitus_Homo sapiens_hsa049300.24937768
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24117359
122Thyroid hormone synthesis_Homo sapiens_hsa049180.23518581
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23393216
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23197281
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22769875
126Glucagon signaling pathway_Homo sapiens_hsa049220.22187536
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21657891
128Pyruvate metabolism_Homo sapiens_hsa006200.19965332
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19421286

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