ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	GDP-mannose metabolic process (GO:0019673)	5.23947431
2	proline biosynthetic process (GO:0006561)	4.08414979
3	ribosomal small subunit biogenesis (GO:0042274)	4.01521883
4	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.98707984
5	DNA strand renaturation (GO:0000733)	3.98058502
6	protein carboxylation (GO:0018214)	3.78178933
7	peptidyl-glutamic acid carboxylation (GO:0017187)	3.78178933
8	urea cycle (GO:0000050)	3.71383752
9	UV protection (GO:0009650)	3.60232630
10	atrioventricular valve morphogenesis (GO:0003181)	3.59291169
11	cellular protein complex localization (GO:0034629)	3.54997787
12	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.43891188
13	basement membrane organization (GO:0071711)	3.43464651
14	regulation of chromatin binding (GO:0035561)	3.39446369
15	glutamine family amino acid biosynthetic process (GO:0009084)	3.39012174
16	sulfur amino acid catabolic process (GO:0000098)	3.37309951
17	pentose metabolic process (GO:0019321)	3.29214445
18	positive regulation of odontogenesis (GO:0042482)	3.27585123
19	viral transcription (GO:0019083)	3.26609244
20	mannose metabolic process (GO:0006013)	3.24988766
21	regulation of glucose import in response to insulin stimulus (GO:2001273)	3.24975677
22	focal adhesion assembly (GO:0048041)	3.24730060
23	cell-substrate adherens junction assembly (GO:0007045)	3.24730060
24	regulation of translational fidelity (GO:0006450)	3.22563300
25	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.22442401
26	urea metabolic process (GO:0019627)	3.21453875
27	protein retention in ER lumen (GO:0006621)	3.19611047
28	regulation of apoptotic process involved in morphogenesis (GO:1902337)	3.13441512
29	mitochondrial fusion (GO:0008053)	3.10243793
30	protein maturation by protein folding (GO:0022417)	3.09320464
31	folic acid metabolic process (GO:0046655)	3.07214312
32	regulation of early endosome to late endosome transport (GO:2000641)	3.04126191
33	nucleotide-sugar biosynthetic process (GO:0009226)	3.01432830
34	translational termination (GO:0006415)	3.00730385
35	negative regulation of glycogen biosynthetic process (GO:0045719)	2.99032612
36	modulation by virus of host process (GO:0019054)	2.98853954
37	negative regulation of cell size (GO:0045792)	2.97349873
38	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.92037485
39	apoptotic process involved in morphogenesis (GO:0060561)	2.91469009
40	adenosine receptor signaling pathway (GO:0001973)	2.91168780
41	modulation by symbiont of host cellular process (GO:0044068)	2.89485422
42	atrial septum morphogenesis (GO:0060413)	2.83753569
43	cellular response to ATP (GO:0071318)	2.82787647
44	adherens junction assembly (GO:0034333)	2.82268812
45	mitotic chromosome condensation (GO:0007076)	2.81867677
46	muscle cell fate commitment (GO:0042693)	2.81420766
47	meiotic chromosome segregation (GO:0045132)	2.80368617
48	amyloid precursor protein catabolic process (GO:0042987)	2.79849071
49	mitotic nuclear envelope reassembly (GO:0007084)	2.77575764
50	nuclear envelope reassembly (GO:0031468)	2.77575764
51	nitrogen cycle metabolic process (GO:0071941)	2.76686620
52	protein complex localization (GO:0031503)	2.75246621
53	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.74659666
54	regulation of skeletal muscle contraction (GO:0014819)	2.74348845
55	embryonic skeletal joint morphogenesis (GO:0060272)	2.74084811
56	cell-substrate junction assembly (GO:0007044)	2.72902328
57	protein insertion into membrane (GO:0051205)	2.68122997
58	translational elongation (GO:0006414)	2.66825775
59	protein hydroxylation (GO:0018126)	2.62015052
60	hyaluronan catabolic process (GO:0030214)	2.61298164
61	rRNA transcription (GO:0009303)	2.60649445
62	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.60037680
63	positive regulation of myotube differentiation (GO:0010831)	2.59650479
64	viral life cycle (GO:0019058)	2.58824237
65	midgut development (GO:0007494)	2.56914995
66	tooth mineralization (GO:0034505)	2.55378544
67	mammary gland epithelial cell differentiation (GO:0060644)	2.54490267
68	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.54172179
69	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.53348635
70	COPI coating of Golgi vesicle (GO:0048205)	2.52652332
71	Golgi transport vesicle coating (GO:0048200)	2.52652332
72	homocysteine metabolic process (GO:0050667)	2.52326458
73	stress fiber assembly (GO:0043149)	2.50436078
74	low-density lipoprotein particle clearance (GO:0034383)	2.48469233
75	snRNA metabolic process (GO:0016073)	2.47966554
76	activation of Rac GTPase activity (GO:0032863)	2.46874505
77	kidney mesenchyme development (GO:0072074)	2.44768684
78	embryo implantation (GO:0007566)	2.42718281
79	negative regulation of fatty acid transport (GO:2000192)	2.41743982
80	adenine nucleotide transport (GO:0051503)	2.41634154
81	response to laminar fluid shear stress (GO:0034616)	2.39496546
82	regulation of fatty acid beta-oxidation (GO:0031998)	2.38462621
83	glycogen catabolic process (GO:0005980)	2.37608715
84	synaptonemal complex assembly (GO:0007130)	2.37256523
85	positive regulation of osteoblast proliferation (GO:0033690)	2.35872985
86	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.35664695
87	peptidyl-proline hydroxylation (GO:0019511)	2.35642780
88	cellular protein complex disassembly (GO:0043624)	2.35529467
89	negative regulation of viral release from host cell (GO:1902187)	2.34671700
90	histone phosphorylation (GO:0016572)	2.34505756
91	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.32620595
92	regulation of glucocorticoid metabolic process (GO:0031943)	2.32555158
93	proline metabolic process (GO:0006560)	2.32169237
94	negative regulation of glycogen metabolic process (GO:0070874)	2.31646417
95	positive regulation of keratinocyte differentiation (GO:0045618)	2.29190172
96	positive regulation of protein export from nucleus (GO:0046827)	2.28586133
97	peptidyl-arginine omega-N-methylation (GO:0035247)	2.28230267
98	lymph vessel development (GO:0001945)	2.27635399
99	positive regulation of p38MAPK cascade (GO:1900745)	2.26339534
100	cochlea morphogenesis (GO:0090103)	2.25579971

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	3.28395605
2	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.05343544
3	LXR_22292898_ChIP-Seq_THP-1_Human	2.61717008
4	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.52717175
5	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.32843647
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.32032596
7	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.29432089
8	XRN2_22483619_ChIP-Seq_HELA_Human	2.27581886
9	RACK7_27058665_Chip-Seq_MCF-7_Human	2.24454416
10	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.17394876
11	MYC_22102868_ChIP-Seq_BL_Human	2.16246831
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.06754637
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.02308347
14	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.98944984
15	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.95054797
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.91717925
17	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.81018379
18	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.79675050
19	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.72106944
20	P68_20966046_ChIP-Seq_HELA_Human	1.71727936
21	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.71723774
22	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.68841842
23	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.66410666
24	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.65921257
25	KDM2B_26808549_Chip-Seq_DND41_Human	1.65572643
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.65139402
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.62057735
28	E2F7_22180533_ChIP-Seq_HELA_Human	1.61809926
29	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.59954491
30	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.59908237
31	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.57514617
32	MAF_26560356_Chip-Seq_TH2_Human	1.56342670
33	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.56153184
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.52514028
35	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.49416873
36	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.49225151
37	ATF3_27146783_Chip-Seq_COLON_Human	1.48953399
38	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.48753959
39	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.48252336
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.47407621
41	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.47029328
42	VDR_24763502_ChIP-Seq_THP-1_Human	1.46932842
43	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.45597101
44	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.45065504
45	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.44899488
46	MAF_26560356_Chip-Seq_TH1_Human	1.42464654
47	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.41656126
48	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.40174378
49	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39126999
50	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.38318295
51	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.36430754
52	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.34838367
53	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.34603496
54	TCF7_22412390_ChIP-Seq_EML_Mouse	1.33790280
55	CTCF_21964334_Chip-Seq_Bcells_Human	1.32954890
56	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.32751275
57	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.32610380
58	CREB1_26743006_Chip-Seq_LNCaP_Human	1.31821928
59	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.30226367
60	SMC4_20622854_ChIP-Seq_HELA_Human	1.29703055
61	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.29518401
62	DCP1A_22483619_ChIP-Seq_HELA_Human	1.28564832
63	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.27429455
64	BCOR_27268052_Chip-Seq_Bcells_Human	1.27343861
65	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.25363514
66	KDM2B_26808549_Chip-Seq_K562_Human	1.25354482
67	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.25227935
68	TP53_22127205_ChIP-Seq_IMR90_Human	1.24037848
69	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.22886378
70	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.22614214
71	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.21716283
72	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.21517832
73	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.20730328
74	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.20370623
75	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.19953830
76	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.19746839
77	NCOR1_26117541_ChIP-Seq_K562_Human	1.19522913
78	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.19385052
79	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.18557261
80	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.17337042
81	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.17155744
82	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.17146822
83	UTX_26944678_Chip-Seq_JUKART_Human	1.16155694
84	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.15483313
85	GABP_19822575_ChIP-Seq_HepG2_Human	1.15072014
86	E2F1_20622854_ChIP-Seq_HELA_Human	1.15041323
87	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.14272453
88	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.12043986
89	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.11503732
90	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.10716037
91	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.10663399
92	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.10397379
93	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09828463
94	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.09293994
95	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.08548822
96	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.07619544
97	BCL6_27268052_Chip-Seq_Bcells_Human	1.07454280
98	CTCF_27219007_Chip-Seq_Bcells_Human	1.07159557
99	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.05761712
100	TTF2_22483619_ChIP-Seq_HELA_Human	1.03296679

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003705_abnormal_hypodermis_morpholog	5.48480258
2	MP0008438_abnormal_cutaneous_collagen	3.59289008
3	MP0005451_abnormal_body_composition	3.33004488
4	MP0005171_absent_coat_pigmentation	3.13439781
5	MP0005058_abnormal_lysosome_morphology	2.83200493
6	MP0010030_abnormal_orbit_morphology	2.80090573
7	MP0000013_abnormal_adipose_tissue	2.72820314
8	MP0005083_abnormal_biliary_tract	2.68685006
9	MP0009840_abnormal_foam_cell	2.55026332
10	MP0000003_abnormal_adipose_tissue	2.38964518
11	MP0002877_abnormal_melanocyte_morpholog	2.38739650
12	MP0002822_catalepsy	2.28165369
13	MP0000751_myopathy	2.25280761
14	MP0005409_darkened_coat_color	2.25087684
15	MP0005623_abnormal_meninges_morphology	2.09778675
16	MP0005257_abnormal_intraocular_pressure	2.09338245
17	MP0005076_abnormal_cell_differentiation	2.07885000
18	MP0001661_extended_life_span	2.04273735
19	MP0004233_abnormal_muscle_weight	1.94408625
20	MP0003111_abnormal_nucleus_morphology	1.93882295
21	MP0003453_abnormal_keratinocyte_physiol	1.91789994
22	MP0000750_abnormal_muscle_regeneration	1.85013335
23	MP0004185_abnormal_adipocyte_glucose	1.82567845
24	MP0001346_abnormal_lacrimal_gland	1.80867984
25	MP0001958_emphysema	1.78333866
26	MP0001849_ear_inflammation	1.76921146
27	MP0004858_abnormal_nervous_system	1.66919271
28	MP0003279_aneurysm	1.66878346
29	MP0000747_muscle_weakness	1.65450492
30	MP0000733_abnormal_muscle_development	1.60968352
31	MP0005375_adipose_tissue_phenotype	1.58704954
32	MP0003091_abnormal_cell_migration	1.56741372
33	MP0005501_abnormal_skin_physiology	1.52959433
34	MP0003959_abnormal_lean_body	1.51693314
35	MP0003566_abnormal_cell_adhesion	1.45044794
36	MP0002060_abnormal_skin_morphology	1.43296499
37	MP0000759_abnormal_skeletal_muscle	1.33864106
38	MP0009384_cardiac_valve_regurgitation	1.33178197
39	MP0004272_abnormal_basement_membrane	1.29487606
40	MP0002249_abnormal_larynx_morphology	1.25512564
41	MP0001188_hyperpigmentation	1.25009173
42	MP0001348_abnormal_lacrimal_gland	1.24182086
43	MP0005666_abnormal_adipose_tissue	1.22187577
44	MP0002089_abnormal_postnatal_growth/wei	1.19488382
45	MP0003077_abnormal_cell_cycle	1.18910804
46	MP0005330_cardiomyopathy	1.17867937
47	MP0004808_abnormal_hematopoietic_stem	1.14778456
48	MP0000678_abnormal_parathyroid_gland	1.14151021
49	MP0004130_abnormal_muscle_cell	1.11247492
50	MP0005023_abnormal_wound_healing	1.06449922
51	MP0001243_abnormal_dermal_layer	1.04903957
52	MP0001873_stomach_inflammation	0.99046629
53	MP0004087_abnormal_muscle_fiber	0.97603560
54	MP0003303_peritoneal_inflammation	0.94837458
55	MP0002796_impaired_skin_barrier	0.93504143
56	MP0009931_abnormal_skin_appearance	0.89053823
57	MP0002896_abnormal_bone_mineralization	0.87941049
58	MP0000350_abnormal_cell_proliferation	0.87462002
59	MP0003172_abnormal_lysosome_physiology	0.84093749
60	MP0003693_abnormal_embryo_hatching	0.83653385
61	MP0005197_abnormal_uvea_morphology	0.82588779
62	MP0003942_abnormal_urinary_system	0.82164490
63	MP0008260_abnormal_autophagy	0.81657029
64	MP0010094_abnormal_chromosome_stability	0.81581798
65	MP0003984_embryonic_growth_retardation	0.80131654
66	MP0005174_abnormal_tail_pigmentation	0.79896799
67	MP0000358_abnormal_cell_content/	0.79435687
68	MP0000490_abnormal_crypts_of	0.78279475
69	MP0004957_abnormal_blastocyst_morpholog	0.78160874
70	MP0002080_prenatal_lethality	0.77654835
71	MP0002396_abnormal_hematopoietic_system	0.77608219
72	MP0000858_altered_metastatic_potential	0.77033993
73	MP0009250_abnormal_appendicular_skeleto	0.75845470
74	MP0000313_abnormal_cell_death	0.75827532
75	MP0002088_abnormal_embryonic_growth/wei	0.74089289
76	MP0008932_abnormal_embryonic_tissue	0.74041018
77	MP0000767_abnormal_smooth_muscle	0.73952359
78	MP0001986_abnormal_taste_sensitivity	0.73945379
79	MP0005621_abnormal_cell_physiology	0.73903132
80	MP0005503_abnormal_tendon_morphology	0.72942235
81	MP0002086_abnormal_extraembryonic_tissu	0.72554067
82	MP0001542_abnormal_bone_strength	0.72518301
83	MP0000538_abnormal_urinary_bladder	0.72004989
84	MP0003136_yellow_coat_color	0.71568590
85	MP0003385_abnormal_body_wall	0.70373062
86	MP0009333_abnormal_splenocyte_physiolog	0.70185978
87	MP0001915_intracranial_hemorrhage	0.68815666
88	MP0005380_embryogenesis_phenotype	0.67391094
89	MP0001672_abnormal_embryogenesis/_devel	0.67391094
90	MP0004381_abnormal_hair_follicle	0.66964723
91	MP0001216_abnormal_epidermal_layer	0.66891437
92	MP0003115_abnormal_respiratory_system	0.66662196
93	MP0005275_abnormal_skin_tensile	0.65379601
94	MP0003123_paternal_imprinting	0.64780599
95	MP0010771_integument_phenotype	0.64742895
96	MP0002092_abnormal_eye_morphology	0.64039263
97	MP0001186_pigmentation_phenotype	0.63484638
98	MP0010307_abnormal_tumor_latency	0.59940583
99	MP0002113_abnormal_skeleton_development	0.59758606
100	MP0001756_abnormal_urination	0.59592956

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	4.43344858
2	Protrusio acetabuli (HP:0003179)	4.16995133
3	Ulnar bowing (HP:0003031)	3.74304011
4	Thin bony cortex (HP:0002753)	3.64723592
5	Premature rupture of membranes (HP:0001788)	3.59037814
6	Hemorrhage of the eye (HP:0011885)	3.05175405
7	Squamous cell carcinoma (HP:0002860)	2.96984121
8	Vertebral compression fractures (HP:0002953)	2.93153054
9	Fragile skin (HP:0001030)	2.90993192
10	Progressive muscle weakness (HP:0003323)	2.84911945
11	Turricephaly (HP:0000262)	2.84450457
12	Poikiloderma (HP:0001029)	2.80318993
13	Myopathic facies (HP:0002058)	2.66558010
14	Elbow flexion contracture (HP:0002987)	2.61358267
15	Thin ribs (HP:0000883)	2.61007760
16	Rib fusion (HP:0000902)	2.60091503
17	Ragged-red muscle fibers (HP:0003200)	2.59422173
18	Mesangial abnormality (HP:0001966)	2.58795424
19	Abnormality of the intrinsic pathway (HP:0010989)	2.55636697
20	Congenital malformation of the right heart (HP:0011723)	2.50132652
21	Double outlet right ventricle (HP:0001719)	2.50132652
22	Aplasia of the musculature (HP:0100854)	2.40707373
23	Long palpebral fissure (HP:0000637)	2.37285716
24	Cervical subluxation (HP:0003308)	2.32038273
25	Slender long bone (HP:0003100)	2.28579108
26	Achilles tendon contracture (HP:0001771)	2.28070610
27	Biconcave vertebral bodies (HP:0004586)	2.22602209
28	Coronal craniosynostosis (HP:0004440)	2.21956959
29	Dyschromatopsia (HP:0007641)	2.20889242
30	Breast hypoplasia (HP:0003187)	2.19708463
31	Popliteal pterygium (HP:0009756)	2.16303783
32	Type 1 muscle fiber predominance (HP:0003803)	2.14035825
33	Akinesia (HP:0002304)	2.13093128
34	Joint stiffness (HP:0001387)	2.12207911
35	Mildly elevated creatine phosphokinase (HP:0008180)	2.11865223
36	Genu recurvatum (HP:0002816)	2.11861064
37	Blue sclerae (HP:0000592)	2.10343612
38	Spondylolisthesis (HP:0003302)	2.09984972
39	Asymmetry of the thorax (HP:0001555)	2.05404292
40	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.05369670
41	Abnormality of the Achilles tendon (HP:0005109)	2.05177261
42	Vaginal fistula (HP:0004320)	2.04358151
43	Bowed forearm bones (HP:0003956)	2.03422593
44	Bowing of the arm (HP:0006488)	2.03422593
45	Intestinal fistula (HP:0100819)	2.02359165
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.97564819
47	Sparse lateral eyebrow (HP:0005338)	1.97344565
48	Asymmetric septal hypertrophy (HP:0001670)	1.96522647
49	Nuclear cataract (HP:0100018)	1.96441136
50	Generalized amyotrophy (HP:0003700)	1.95794243
51	Distal lower limb amyotrophy (HP:0008944)	1.95402407
52	Increased variability in muscle fiber diameter (HP:0003557)	1.94051618
53	Rectovaginal fistula (HP:0000143)	1.93646510
54	Rectal fistula (HP:0100590)	1.93646510
55	Syringomyelia (HP:0003396)	1.93634439
56	Spinal cord lesions (HP:0100561)	1.93634439
57	Wormian bones (HP:0002645)	1.93070439
58	Hyperacusis (HP:0010780)	1.92317641
59	Ulnar deviation of the wrist (HP:0003049)	1.92087166
60	Fetal akinesia sequence (HP:0001989)	1.91463206
61	Mitral regurgitation (HP:0001653)	1.90530489
62	Anteriorly placed anus (HP:0001545)	1.89836772
63	Dislocated radial head (HP:0003083)	1.89144711
64	Renal Fanconi syndrome (HP:0001994)	1.86647786
65	Soft skin (HP:0000977)	1.86444975
66	Spinal rigidity (HP:0003306)	1.86364616
67	Cholelithiasis (HP:0001081)	1.84034814
68	Annular pancreas (HP:0001734)	1.83825154
69	Bladder diverticulum (HP:0000015)	1.83023893
70	Short nail (HP:0001799)	1.82568589
71	Zonular cataract (HP:0010920)	1.82188099
72	Hypercortisolism (HP:0001578)	1.81134585
73	Disproportionate tall stature (HP:0001519)	1.78265114
74	Distal lower limb muscle weakness (HP:0009053)	1.75746831
75	Abnormal gallbladder morphology (HP:0012437)	1.74983142
76	Ankle contracture (HP:0006466)	1.74401063
77	Aortic aneurysm (HP:0004942)	1.73216709
78	Abnormality of the radial head (HP:0003995)	1.73153710
79	Hypertensive crisis (HP:0100735)	1.71838526
80	Abnormal trabecular bone morphology (HP:0100671)	1.71487846
81	Shallow orbits (HP:0000586)	1.70715095
82	Easy fatigability (HP:0003388)	1.70589947
83	Truncus arteriosus (HP:0001660)	1.70026357
84	Entropion (HP:0000621)	1.69429291
85	Abnormality of skeletal muscle fiber size (HP:0012084)	1.69340661
86	Pterygium (HP:0001059)	1.69225131
87	Increased connective tissue (HP:0009025)	1.67415732
88	Trismus (HP:0000211)	1.66932941
89	Abnormality of the gallbladder (HP:0005264)	1.66468430
90	Increased muscle lipid content (HP:0009058)	1.65067259
91	Rectal prolapse (HP:0002035)	1.64667106
92	Neonatal onset (HP:0003623)	1.64659564
93	Abnormality of cells of the erythroid lineage (HP:0012130)	1.63425410
94	Cerebral aneurysm (HP:0004944)	1.63252884
95	Mucopolysacchariduria (HP:0008155)	1.63228671
96	Urinary glycosaminoglycan excretion (HP:0003541)	1.63228671
97	Self-mutilation (HP:0000742)	1.63022420
98	Rough bone trabeculation (HP:0100670)	1.62442962
99	Vascular tortuosity (HP:0004948)	1.62210004
100	Hyperextensible skin (HP:0000974)	1.61205544

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.79361912
2	SMG1	4.10340311
3	IRAK3	3.13974748
4	ICK	2.90803510
5	SIK1	2.76898555
6	NME2	2.73564485
7	EEF2K	2.50012449
8	PIM2	2.45583227
9	MAP2K3	2.37328138
10	ERN1	2.35772125
11	STK16	2.09320077
12	VRK2	2.08072495
13	PDK2	2.01404096
14	TTN	1.96288655
15	AKT3	1.76286639
16	MAPK15	1.66587377
17	TLK1	1.61636525
18	CDK12	1.51160726
19	TAOK2	1.49001273
20	MAPK11	1.43784642
21	BUB1	1.41515802
22	PRPF4B	1.34554279
23	PKN2	1.31166527
24	PRKD3	1.30059084
25	LATS2	1.29744385
26	TESK2	1.27870196
27	BRAF	1.23066961
28	PRKD2	1.21499529
29	IRAK2	1.16788900
30	TAF1	1.11280346
31	MAP3K3	1.09706252
32	DAPK3	1.08209131
33	PDPK1	1.07693931
34	MTOR	1.07623465
35	AURKA	1.01661112
36	MAPK12	0.98244169
37	MAP3K11	0.97841398
38	ARAF	0.95220791
39	NEK2	0.94528105
40	EPHA2	0.92097538
41	ABL2	0.91787839
42	PDGFRA	0.91656608
43	PTK2	0.88760025
44	MUSK	0.84703508
45	CDK8	0.84688209
46	MELK	0.83558482
47	AKT2	0.83051683
48	PTK6	0.79991415
49	CDK4	0.76044698
50	PAK4	0.74240846
51	MAPKAPK5	0.73064067
52	ZAK	0.72583583
53	CHEK2	0.72530906
54	CDK7	0.71806725
55	TESK1	0.71227967
56	BMX	0.70169073
57	EPHB2	0.70051791
58	RPS6KB2	0.69890040
59	FGFR4	0.69853341
60	MST1R	0.68710347
61	RPS6KA2	0.68331895
62	RPS6KL1	0.67727933
63	RPS6KC1	0.67727933
64	BLK	0.67475834
65	MAPKAPK3	0.66470567
66	MAP3K8	0.66301698
67	MAP2K2	0.65281594
68	LRRK2	0.63941844
69	ILK	0.63723820
70	PAK2	0.62203167
71	TAOK1	0.59815760
72	TBK1	0.59681885
73	HIPK2	0.55404713
74	ZAP70	0.54157141
75	DDR2	0.53996394
76	MOS	0.53957189
77	WNK4	0.53765364
78	NEK9	0.53572575
79	SCYL2	0.52177411
80	DYRK1B	0.51766907
81	BRSK1	0.51260629
82	RPS6KA5	0.50867442
83	MAP2K6	0.49793574
84	RPS6KA6	0.49108273
85	RIPK1	0.48451650
86	MARK2	0.47837214
87	DAPK1	0.46144281
88	RAF1	0.45620843
89	DYRK3	0.45586543
90	GRK6	0.44092637
91	MAP3K1	0.43995606
92	MAP3K7	0.42925919
93	PAK1	0.42844412
94	GSK3A	0.40860733
95	CDC42BPA	0.40094458
96	CAMK1D	0.39507319
97	CDK11A	0.35800048
98	CDK6	0.35582910
99	IKBKB	0.35536772
100	MET	0.35176017

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	4.99494634
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.22643749
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.70326787
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.69125061
5	Other glycan degradation_Homo sapiens_hsa00511	2.64325575
6	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.47742815
7	Bladder cancer_Homo sapiens_hsa05219	2.37650493
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.28205317
9	Ribosome_Homo sapiens_hsa03010	2.06775014
10	Arginine biosynthesis_Homo sapiens_hsa00220	1.99525627
11	Pentose phosphate pathway_Homo sapiens_hsa00030	1.97494603
12	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.85910443
13	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.73809784
14	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.56896623
15	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.51126347
16	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.50599289
17	Non-small cell lung cancer_Homo sapiens_hsa05223	1.47641696
18	Alcoholism_Homo sapiens_hsa05034	1.33836059
19	Small cell lung cancer_Homo sapiens_hsa05222	1.33574691
20	mTOR signaling pathway_Homo sapiens_hsa04150	1.32164864
21	Acute myeloid leukemia_Homo sapiens_hsa05221	1.30855004
22	Sphingolipid metabolism_Homo sapiens_hsa00600	1.30471470
23	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.29169957
24	DNA replication_Homo sapiens_hsa03030	1.23306477
25	Base excision repair_Homo sapiens_hsa03410	1.22671552
26	Endometrial cancer_Homo sapiens_hsa05213	1.20274135
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.20245172
28	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.18743941
29	Galactose metabolism_Homo sapiens_hsa00052	1.16059626
30	Sulfur metabolism_Homo sapiens_hsa00920	1.15887968
31	Thyroid cancer_Homo sapiens_hsa05216	1.14581593
32	VEGF signaling pathway_Homo sapiens_hsa04370	1.07528784
33	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.07009191
34	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.06627898
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05275243
36	Pancreatic cancer_Homo sapiens_hsa05212	1.03787759
37	Notch signaling pathway_Homo sapiens_hsa04330	1.02154108
38	Lysosome_Homo sapiens_hsa04142	1.00976686
39	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.96680591
40	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95348116
41	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.94028613
42	Cell cycle_Homo sapiens_hsa04110	0.93838872
43	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.93010099
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90981094
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.87610714
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.87453253
47	Carbon metabolism_Homo sapiens_hsa01200	0.87447252
48	Viral carcinogenesis_Homo sapiens_hsa05203	0.86237766
49	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.83718662
50	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.83170083
51	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.81532076
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.79066009
53	Insulin resistance_Homo sapiens_hsa04931	0.76444454
54	Glioma_Homo sapiens_hsa05214	0.75577953
55	MicroRNAs in cancer_Homo sapiens_hsa05206	0.73417499
56	Insulin signaling pathway_Homo sapiens_hsa04910	0.73376058
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71815846
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.71549762
59	Prion diseases_Homo sapiens_hsa05020	0.71301305
60	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.70903334
61	Melanoma_Homo sapiens_hsa05218	0.69510274
62	ECM-receptor interaction_Homo sapiens_hsa04512	0.69353428
63	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.67709281
64	Prostate cancer_Homo sapiens_hsa05215	0.67032059
65	Proteoglycans in cancer_Homo sapiens_hsa05205	0.66822127
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.65899703
67	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.65860228
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64553059
69	Apoptosis_Homo sapiens_hsa04210	0.64086102
70	HTLV-I infection_Homo sapiens_hsa05166	0.63511684
71	Hepatitis C_Homo sapiens_hsa05160	0.61504198
72	AMPK signaling pathway_Homo sapiens_hsa04152	0.60989582
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60221084
74	Focal adhesion_Homo sapiens_hsa04510	0.58617307
75	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.56780593
76	Hepatitis B_Homo sapiens_hsa05161	0.55913783
77	p53 signaling pathway_Homo sapiens_hsa04115	0.55693316
78	Folate biosynthesis_Homo sapiens_hsa00790	0.55336457
79	Renal cell carcinoma_Homo sapiens_hsa05211	0.53954564
80	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.51987352
81	Colorectal cancer_Homo sapiens_hsa05210	0.51362257
82	Lysine degradation_Homo sapiens_hsa00310	0.50857844
83	Amoebiasis_Homo sapiens_hsa05146	0.49626903
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48580940
85	TNF signaling pathway_Homo sapiens_hsa04668	0.46705971
86	One carbon pool by folate_Homo sapiens_hsa00670	0.45404156
87	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.43547389
88	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.43054317
89	Melanogenesis_Homo sapiens_hsa04916	0.43010880
90	Glucagon signaling pathway_Homo sapiens_hsa04922	0.42333599
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.39971723
92	Endocytosis_Homo sapiens_hsa04144	0.39589082
93	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.39567144
94	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.38098114
95	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.37888228
96	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36287871
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35879703
98	Glutathione metabolism_Homo sapiens_hsa00480	0.35623816
99	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.34515054
100	Pathways in cancer_Homo sapiens_hsa05200	0.34498768

SSR4P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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