SSRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.05858426
2protein localization to kinetochore (GO:0034501)5.08179938
3DNA strand elongation involved in DNA replication (GO:0006271)4.71760875
4nuclear pore organization (GO:0006999)4.54287762
5DNA replication initiation (GO:0006270)4.47222104
6DNA strand elongation (GO:0022616)4.46248985
7nuclear pore complex assembly (GO:0051292)4.40952863
8protein localization to chromosome, centromeric region (GO:0071459)4.24260126
9folic acid-containing compound biosynthetic process (GO:0009396)4.16295393
10mitotic nuclear envelope disassembly (GO:0007077)4.15386544
11telomere maintenance via semi-conservative replication (GO:0032201)4.12730674
12mitotic chromosome condensation (GO:0007076)4.12476162
13sister chromatid segregation (GO:0000819)4.02808380
14DNA replication-dependent nucleosome organization (GO:0034723)4.00341705
15DNA replication-dependent nucleosome assembly (GO:0006335)4.00341705
16mitotic sister chromatid segregation (GO:0000070)3.97023799
17formation of translation preinitiation complex (GO:0001731)3.94168622
18ribosomal small subunit biogenesis (GO:0042274)3.89594139
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.89100049
20nuclear envelope disassembly (GO:0051081)3.88451752
21membrane disassembly (GO:0030397)3.88451752
22DNA duplex unwinding (GO:0032508)3.85558526
23DNA geometric change (GO:0032392)3.83849311
24mitotic metaphase plate congression (GO:0007080)3.82792281
25protein complex localization (GO:0031503)3.82327417
26DNA replication checkpoint (GO:0000076)3.81851149
27negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.80693966
28mitotic recombination (GO:0006312)3.80569660
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.80409178
30IMP biosynthetic process (GO:0006188)3.73782292
31mitotic sister chromatid cohesion (GO:0007064)3.72677805
32telomere maintenance via recombination (GO:0000722)3.71507862
33ribosomal small subunit assembly (GO:0000028)3.63915904
34maturation of SSU-rRNA (GO:0030490)3.56184654
35negative regulation of RNA splicing (GO:0033119)3.55062142
36nucleobase biosynthetic process (GO:0046112)3.53028220
37viral transcription (GO:0019083)3.48621021
38positive regulation of chromosome segregation (GO:0051984)3.46964465
39protein-DNA complex disassembly (GO:0032986)3.46105227
40nucleosome disassembly (GO:0006337)3.46105227
41translational termination (GO:0006415)3.45898308
42metaphase plate congression (GO:0051310)3.45840447
43heterochromatin organization (GO:0070828)3.44569402
44cellular protein complex localization (GO:0034629)3.41864962
45kinetochore organization (GO:0051383)3.41342462
46regulation of translational fidelity (GO:0006450)3.39431947
47telomere maintenance via telomere lengthening (GO:0010833)3.37313084
48chromatin remodeling at centromere (GO:0031055)3.36534891
49pore complex assembly (GO:0046931)3.36262333
50translesion synthesis (GO:0019985)3.35959127
51CENP-A containing nucleosome assembly (GO:0034080)3.33094740
52DNA replication-independent nucleosome organization (GO:0034724)3.32787222
53DNA replication-independent nucleosome assembly (GO:0006336)3.32787222
54attachment of spindle microtubules to kinetochore (GO:0008608)3.32034563
55nucleotide-excision repair, DNA gap filling (GO:0006297)3.31838134
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.31148346
57regulation of mitotic spindle organization (GO:0060236)3.30562519
58dosage compensation (GO:0007549)3.29617289
59IMP metabolic process (GO:0046040)3.29509920
60DNA topological change (GO:0006265)3.29291625
61negative regulation of mRNA processing (GO:0050686)3.28234689
62establishment of viral latency (GO:0019043)3.27601569
63regulation of spindle organization (GO:0090224)3.26973775
64DNA packaging (GO:0006323)3.25498972
65RNA stabilization (GO:0043489)3.25109734
66mRNA stabilization (GO:0048255)3.25109734
67regulation of histone H3-K9 methylation (GO:0051570)3.24262612
68DNA conformation change (GO:0071103)3.23640834
69translational initiation (GO:0006413)3.22042756
70translational elongation (GO:0006414)3.21922112
71protein localization to chromosome (GO:0034502)3.21464821
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20962677
73proline biosynthetic process (GO:0006561)3.19464300
74chromatin assembly or disassembly (GO:0006333)3.18772862
75establishment of chromosome localization (GO:0051303)3.17740750
76regulation of sister chromatid cohesion (GO:0007063)3.16565833
77establishment of integrated proviral latency (GO:0075713)3.15183492
78pre-miRNA processing (GO:0031054)3.14827536
79ribonucleoprotein complex biogenesis (GO:0022613)3.14718882
80mRNA splicing, via spliceosome (GO:0000398)3.12460007
81RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.12460007
82regulation of translational termination (GO:0006449)3.12043225
83negative regulation of histone methylation (GO:0031061)3.11536271
84regulation of chromosome segregation (GO:0051983)3.11188253
85RNA splicing, via transesterification reactions (GO:0000375)3.09926485
86chromosome condensation (GO:0030261)3.08950760
87positive regulation of mitotic sister chromatid separation (GO:1901970)3.08527055
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.08527055
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.08527055
90regulation of nucleobase-containing compound transport (GO:0032239)3.08266059
91nuclear envelope organization (GO:0006998)3.07000009
92postreplication repair (GO:0006301)3.05611973
93chromatin assembly (GO:0031497)3.04915710
94nucleobase-containing small molecule interconversion (GO:0015949)3.03153540
95ribosome biogenesis (GO:0042254)3.02735228
96positive regulation of DNA-dependent DNA replication (GO:2000105)3.02406746
97DNA synthesis involved in DNA repair (GO:0000731)3.01306788
98ATP-dependent chromatin remodeling (GO:0043044)3.00298644
99negative regulation of mRNA metabolic process (GO:1903312)2.98016024
100alternative mRNA splicing, via spliceosome (GO:0000380)2.97780010
101ribosomal large subunit biogenesis (GO:0042273)2.97674361
102peptidyl-arginine omega-N-methylation (GO:0035247)2.97238883
103double-strand break repair via nonhomologous end joining (GO:0006303)2.96262111
104non-recombinational repair (GO:0000726)2.96262111
105protein export from nucleus (GO:0006611)2.95182135
106regulation of mammary gland epithelial cell proliferation (GO:0033599)2.93642572
107purine nucleobase biosynthetic process (GO:0009113)2.93506108
108spliceosomal tri-snRNP complex assembly (GO:0000244)2.92382251
109L-serine metabolic process (GO:0006563)2.91576459
110negative regulation of chromosome segregation (GO:0051985)2.91231645
111ribosome assembly (GO:0042255)2.90570960
112COPI coating of Golgi vesicle (GO:0048205)2.90522370
113Golgi transport vesicle coating (GO:0048200)2.90522370
114somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90250606
115somatic hypermutation of immunoglobulin genes (GO:0016446)2.90250606
116histone exchange (GO:0043486)2.89543767
117spindle checkpoint (GO:0031577)2.88682081
118spindle assembly checkpoint (GO:0071173)2.88393067
119regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88203989
120regulation of RNA export from nucleus (GO:0046831)2.86787756
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.86545439
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86545439
123negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86545439
124negative regulation of sister chromatid segregation (GO:0033046)2.86545439
125regulation of centrosome cycle (GO:0046605)2.85838362
126chromosome segregation (GO:0007059)2.84269989
127mRNA transport (GO:0051028)2.76328242
128regulation of translational elongation (GO:0006448)2.75732448
129histone arginine methylation (GO:0034969)2.74920461
130DNA ligation (GO:0006266)2.74112228
131viral mRNA export from host cell nucleus (GO:0046784)2.72412923
132peptidyl-arginine methylation (GO:0018216)2.69770483
133peptidyl-arginine N-methylation (GO:0035246)2.69770483
134rRNA transcription (GO:0009303)2.69511523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.22508500
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.01822317
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01580266
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69252713
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40402617
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.01638335
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93886239
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58558461
9MYC_22102868_ChIP-Seq_BL_Human2.51834355
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35627084
11AR_21909140_ChIP-Seq_LNCAP_Human2.34581341
12XRN2_22483619_ChIP-Seq_HELA_Human2.31384461
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23191466
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.23157960
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.22671014
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11835597
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09781985
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.09777180
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04810859
20E2F7_22180533_ChIP-Seq_HELA_Human10.0455411
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99082102
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98237642
23CIITA_25753668_ChIP-Seq_RAJI_Human1.96793936
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.88522882
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85230755
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79048902
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76635079
28VDR_23849224_ChIP-Seq_CD4+_Human1.74293109
29TTF2_22483619_ChIP-Seq_HELA_Human1.72488569
30FOXP3_21729870_ChIP-Seq_TREG_Human1.72282143
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70241283
32ZNF263_19887448_ChIP-Seq_K562_Human1.70175340
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.67303687
34DCP1A_22483619_ChIP-Seq_HELA_Human1.62427349
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61951562
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60777818
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59353440
38GABP_19822575_ChIP-Seq_HepG2_Human1.59203273
39* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59086925
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56925011
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55300056
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53610771
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51302276
44KDM5A_27292631_Chip-Seq_BREAST_Human1.51039377
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48623039
46VDR_21846776_ChIP-Seq_THP-1_Human1.47188337
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46311049
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43740852
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40968186
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40606297
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39866690
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38643734
53ELK1_19687146_ChIP-ChIP_HELA_Human1.38103233
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35826119
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.27883695
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26020731
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24095693
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22110211
59TFEB_21752829_ChIP-Seq_HELA_Human1.21676174
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21512174
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19478942
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19413428
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19330132
64CLOCK_20551151_ChIP-Seq_293T_Human1.18761177
65* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18511527
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17969345
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15517933
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14380636
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13421448
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.12097081
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11111532
72* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10602619
73HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10548376
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09837039
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09514276
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09331788
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08378962
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08340453
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07417166
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07153489
81RACK7_27058665_Chip-Seq_MCF-7_Human1.05258625
82* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04800530
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04062281
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03083131
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02344443
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00855635
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00206575
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.98521709
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97530449
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97383089
91* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97341170
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97225014
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96683708
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96271688
95* UTX_26944678_Chip-Seq_JUKART_Human0.94817697
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.94330062
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93336693
98TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93229608
99ATF3_27146783_Chip-Seq_COLON_Human0.92724195
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91834095
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91089165
102CHD1_26751641_Chip-Seq_LNCaP_Human0.89204022
103MAF_26560356_Chip-Seq_TH1_Human0.88791202
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88360604
105* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88039721
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87476682
107* NCOR1_26117541_ChIP-Seq_K562_Human0.86860261
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86714452
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.86479442
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85776567
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85623608
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85523638
113* LXR_22292898_ChIP-Seq_THP-1_Human0.85360586
114TCF7_22412390_ChIP-Seq_EML_Mouse0.85151951
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84748021
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83606892
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83288336
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83249678
119SPI1_23547873_ChIP-Seq_NB4_Human0.82330944
120MYC_18940864_ChIP-ChIP_HL60_Human0.82183672
121* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81203829
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80270315
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79914687
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.79412005
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78827769
126MYB_26560356_Chip-Seq_TH2_Human0.78094505
127MYB_26560356_Chip-Seq_TH1_Human0.77106892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.28907273
2MP0010094_abnormal_chromosome_stability4.21403757
3MP0003111_abnormal_nucleus_morphology3.98568629
4* MP0004957_abnormal_blastocyst_morpholog3.80984689
5MP0003077_abnormal_cell_cycle3.66420817
6MP0008057_abnormal_DNA_replication3.40022839
7MP0010352_gastrointestinal_tract_polyps3.02939288
8MP0008007_abnormal_cellular_replicative2.60260457
9MP0003123_paternal_imprinting2.55308305
10MP0001730_embryonic_growth_arrest2.49516405
11MP0008058_abnormal_DNA_repair2.41446634
12MP0000350_abnormal_cell_proliferation2.32817368
13MP0008932_abnormal_embryonic_tissue2.31136342
14MP0002396_abnormal_hematopoietic_system2.29284172
15MP0010307_abnormal_tumor_latency2.09099483
16MP0004185_abnormal_adipocyte_glucose2.05814287
17MP0005076_abnormal_cell_differentiation2.03465364
18MP0003705_abnormal_hypodermis_morpholog1.99241620
19MP0001697_abnormal_embryo_size1.89904349
20MP0000537_abnormal_urethra_morphology1.86048484
21MP0010030_abnormal_orbit_morphology1.85405547
22MP0004808_abnormal_hematopoietic_stem1.82745908
23MP0004197_abnormal_fetal_growth/weight/1.82694308
24MP0001672_abnormal_embryogenesis/_devel1.82279961
25MP0005380_embryogenesis_phenotype1.82279961
26MP0002084_abnormal_developmental_patter1.76053231
27MP0003121_genomic_imprinting1.72507306
28* MP0002085_abnormal_embryonic_tissue1.71207956
29* MP0002080_prenatal_lethality1.69381281
30MP0003984_embryonic_growth_retardation1.68336106
31MP0002088_abnormal_embryonic_growth/wei1.65986496
32MP0000490_abnormal_crypts_of1.62961375
33MP0002086_abnormal_extraembryonic_tissu1.59819809
34MP0006054_spinal_hemorrhage1.59083402
35MP0005623_abnormal_meninges_morphology1.53136999
36MP0009053_abnormal_anal_canal1.52201378
37MP0001346_abnormal_lacrimal_gland1.51756186
38MP0003567_abnormal_fetal_cardiomyocyte1.51291909
39MP0008877_abnormal_DNA_methylation1.47909116
40MP0000566_synostosis1.42641016
41MP0003890_abnormal_embryonic-extraembry1.39728498
42MP0002019_abnormal_tumor_incidence1.35770301
43MP0000313_abnormal_cell_death1.35185797
44MP0005501_abnormal_skin_physiology1.33812855
45MP0000703_abnormal_thymus_morphology1.32956502
46MP0009278_abnormal_bone_marrow1.29924724
47MP0001293_anophthalmia1.29453794
48MP0003763_abnormal_thymus_physiology1.28383674
49MP0002796_impaired_skin_barrier1.26448913
50MP0000678_abnormal_parathyroid_gland1.26447216
51MP0003786_premature_aging1.21707563
52MP0009697_abnormal_copulation1.20112383
53MP0002009_preneoplasia1.18882347
54MP0009379_abnormal_foot_pigmentation1.15515050
55MP0003941_abnormal_skin_development1.14713313
56MP0003119_abnormal_digestive_system1.12614112
57MP0002398_abnormal_bone_marrow1.12057485
58MP0003566_abnormal_cell_adhesion1.10816833
59MP0002249_abnormal_larynx_morphology1.10450376
60MP0000428_abnormal_craniofacial_morphol1.09512899
61MP0001915_intracranial_hemorrhage1.09471907
62MP0001849_ear_inflammation1.06287322
63MP0009333_abnormal_splenocyte_physiolog1.04090884
64MP0005023_abnormal_wound_healing1.03750920
65MP0002877_abnormal_melanocyte_morpholog1.03231215
66MP0005451_abnormal_body_composition1.01613889
67MP0002722_abnormal_immune_system1.01553697
68MP0000762_abnormal_tongue_morphology1.00807733
69MP0009672_abnormal_birth_weight0.99419394
70MP0003315_abnormal_perineum_morphology0.98427913
71MP0010234_abnormal_vibrissa_follicle0.98282096
72MP0000733_abnormal_muscle_development0.98132903
73MP0005397_hematopoietic_system_phenotyp0.97350881
74MP0001545_abnormal_hematopoietic_system0.97350881
75MP0002111_abnormal_tail_morphology0.97110775
76MP0003937_abnormal_limbs/digits/tail_de0.96885204
77MP0001661_extended_life_span0.95351730
78MP0005257_abnormal_intraocular_pressure0.95310876
79MP0003115_abnormal_respiratory_system0.94633062
80MP0004272_abnormal_basement_membrane0.94358364
81MP0000579_abnormal_nail_morphology0.93878932
82MP0009703_decreased_birth_body0.90976998
83MP0000689_abnormal_spleen_morphology0.90502520
84MP0002092_abnormal_eye_morphology0.89913180
85MP0000858_altered_metastatic_potential0.88544286
86MP0002060_abnormal_skin_morphology0.85440993
87MP0004858_abnormal_nervous_system0.84453857
88MP0002697_abnormal_eye_size0.82839473
89MP0000477_abnormal_intestine_morphology0.82644267
90MP0005666_abnormal_adipose_tissue0.81738857
91MP0002210_abnormal_sex_determination0.79710787
92MP0003453_abnormal_keratinocyte_physiol0.79571774
93MP0003942_abnormal_urinary_system0.79358864
94MP0002429_abnormal_blood_cell0.78683082
95MP0006292_abnormal_olfactory_placode0.78597696
96MP0003755_abnormal_palate_morphology0.77617019
97MP0003935_abnormal_craniofacial_develop0.76436790
98MP0000003_abnormal_adipose_tissue0.76378407
99MP0005384_cellular_phenotype0.75763608
100MP0002925_abnormal_cardiovascular_devel0.75333678
101MP0003300_gastrointestinal_ulcer0.75087179
102MP0002081_perinatal_lethality0.74753430
103MP0005621_abnormal_cell_physiology0.74479561
104MP0010630_abnormal_cardiac_muscle0.74275050
105MP0001145_abnormal_male_reproductive0.73616426
106MP0001348_abnormal_lacrimal_gland0.73347124
107MP0002932_abnormal_joint_morphology0.73122858
108MP0000432_abnormal_head_morphology0.72877804
109MP0001286_abnormal_eye_development0.72865833
110MP0002089_abnormal_postnatal_growth/wei0.72720909
111MP0000534_abnormal_ureter_morphology0.71856104
112MP0002233_abnormal_nose_morphology0.71620643
113MP0008770_decreased_survivor_rate0.71600014
114MP0004264_abnormal_extraembryonic_tissu0.70708407
115MP0001216_abnormal_epidermal_layer0.68523645
116MP0003861_abnormal_nervous_system0.66762016
117MP0003122_maternal_imprinting0.66573092
118MP0002653_abnormal_ependyma_morphology0.66511964
119MP0003385_abnormal_body_wall0.65435185
120MP0000716_abnormal_immune_system0.65250767
121MP0000358_abnormal_cell_content/0.64620918
122MP0003221_abnormal_cardiomyocyte_apopto0.64273224
123MP0003283_abnormal_digestive_organ0.64200746
124MP0002114_abnormal_axial_skeleton0.64065370
125MP0002938_white_spotting0.64059706
126MP0004233_abnormal_muscle_weight0.63876195
127MP0000049_abnormal_middle_ear0.60929039
128MP0005187_abnormal_penis_morphology0.60868247
129MP0002282_abnormal_trachea_morphology0.59566952
130MP0000653_abnormal_sex_gland0.56205969
131MP0002160_abnormal_reproductive_system0.55599696
132MP0000465_gastrointestinal_hemorrhage0.55500055

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.54639870
2Colon cancer (HP:0003003)3.39331329
3Selective tooth agenesis (HP:0001592)3.38828166
4Reticulocytopenia (HP:0001896)3.35671649
5Birth length less than 3rd percentile (HP:0003561)3.18193407
6Increased nuchal translucency (HP:0010880)3.17551605
7Medulloblastoma (HP:0002885)3.15236875
8Insomnia (HP:0100785)3.14800485
9Short 4th metacarpal (HP:0010044)2.98078653
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.98078653
11Proximal placement of thumb (HP:0009623)2.97839962
12Deviation of the thumb (HP:0009603)2.93686566
13Volvulus (HP:0002580)2.89667159
14Patellar aplasia (HP:0006443)2.74325135
15High anterior hairline (HP:0009890)2.73682537
16Progressive muscle weakness (HP:0003323)2.73048085
17Abnormality of cells of the erythroid lineage (HP:0012130)2.72571268
18Basal cell carcinoma (HP:0002671)2.69745772
19Abnormal number of incisors (HP:0011064)2.66681829
20Aplasia/Hypoplasia of the patella (HP:0006498)2.58560534
21Cortical dysplasia (HP:0002539)2.56737752
22Astrocytoma (HP:0009592)2.56470020
23Abnormality of the astrocytes (HP:0100707)2.56470020
24Atresia of the external auditory canal (HP:0000413)2.55028298
25Abnormality of the anterior horn cell (HP:0006802)2.52817590
26Degeneration of anterior horn cells (HP:0002398)2.52817590
27Multiple enchondromatosis (HP:0005701)2.50928174
28Abnormality of chromosome stability (HP:0003220)2.48258028
29Hyperacusis (HP:0010780)2.48246954
30Renal duplication (HP:0000075)2.46746812
31Rhabdomyosarcoma (HP:0002859)2.46203629
32Chromsome breakage (HP:0040012)2.45525446
33Progressive external ophthalmoplegia (HP:0000590)2.41324382
34High pitched voice (HP:0001620)2.38383493
35Overlapping toe (HP:0001845)2.35767186
36Abnormal number of erythroid precursors (HP:0012131)2.35080162
37Missing ribs (HP:0000921)2.33965481
3811 pairs of ribs (HP:0000878)2.32024884
39Elfin facies (HP:0004428)2.31827994
40Ankyloglossia (HP:0010296)2.31164145
41Meckel diverticulum (HP:0002245)2.30426882
42Myelodysplasia (HP:0002863)2.28387326
43Abnormal lung lobation (HP:0002101)2.26830477
44Ulnar bowing (HP:0003031)2.26283229
45Thrombocytosis (HP:0001894)2.26184627
46Neoplasm of the pancreas (HP:0002894)2.24310938
47Absent thumb (HP:0009777)2.24232731
48Abnormality of the ileum (HP:0001549)2.20495238
49Abnormality of the calcaneus (HP:0008364)2.20112106
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.19193780
51Agnosia (HP:0010524)2.19011829
52Abnormality of the 4th metacarpal (HP:0010012)2.18440311
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17497839
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15888924
55Glioma (HP:0009733)2.15397008
56Increased density of long bones (HP:0006392)2.14864375
57Asymmetry of the thorax (HP:0001555)2.13543291
58Facial hemangioma (HP:0000329)2.13066899
59Broad distal phalanx of finger (HP:0009836)2.12043528
60Oral leukoplakia (HP:0002745)2.10535707
61Small intestinal stenosis (HP:0012848)2.09868762
62Duodenal stenosis (HP:0100867)2.09868762
63Ectopic kidney (HP:0000086)2.09494157
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.09350731
65Neoplasm of striated muscle (HP:0009728)2.08904173
66Microvesicular hepatic steatosis (HP:0001414)2.07467427
67Abnormality of cochlea (HP:0000375)2.05923310
68Abnormality of the preputium (HP:0100587)2.05077702
69Breast hypoplasia (HP:0003187)2.03344060
70Duplication of thumb phalanx (HP:0009942)2.03145397
71Cutaneous melanoma (HP:0012056)2.03044186
72Cafe-au-lait spot (HP:0000957)1.99998071
73Squamous cell carcinoma (HP:0002860)1.97878368
74Pseudobulbar signs (HP:0002200)1.96333495
75Termporal pattern (HP:0011008)1.95948984
76Insidious onset (HP:0003587)1.95948984
77Urethral obstruction (HP:0000796)1.93073243
78Long palpebral fissure (HP:0000637)1.93027332
79Abnormality of the labia minora (HP:0012880)1.92251159
80Abnormality of the carotid arteries (HP:0005344)1.92049480
81Prominent nose (HP:0000448)1.91970849
82Deep palmar crease (HP:0006191)1.91809876
83Trismus (HP:0000211)1.91433406
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.91265038
85Abnormality of the phalanges of the hallux (HP:0010057)1.89794133
86Adenoma sebaceum (HP:0009720)1.89404586
87Angiofibromas (HP:0010615)1.89404586
88Amaurosis fugax (HP:0100576)1.88163621
89Biliary tract neoplasm (HP:0100574)1.87841389
90Aplastic anemia (HP:0001915)1.87760990
91Dysmetric saccades (HP:0000641)1.87586586
92Pelvic girdle muscle weakness (HP:0003749)1.86724712
93Neoplasm of the oral cavity (HP:0100649)1.86633149
94Abnormality of oral frenula (HP:0000190)1.86614303
95Patellar dislocation (HP:0002999)1.86379064
96Nephroblastoma (Wilms tumor) (HP:0002667)1.85783181
97Disproportionate tall stature (HP:0001519)1.84553445
98Broad palm (HP:0001169)1.84329352
99Skin tags (HP:0010609)1.83662467
100Abnormality of glycolysis (HP:0004366)1.82900466
101Septate vagina (HP:0001153)1.82867168
102Long eyelashes (HP:0000527)1.82537941
103Malignant gastrointestinal tract tumors (HP:0006749)1.81972637
104Gastrointestinal carcinoma (HP:0002672)1.81972637
105Slender long bone (HP:0003100)1.80222247
106Spastic diplegia (HP:0001264)1.80139088
107Achilles tendon contracture (HP:0001771)1.79884657
108Glossoptosis (HP:0000162)1.79389099
109Tracheoesophageal fistula (HP:0002575)1.78464578
110Macrocytic anemia (HP:0001972)1.78308109
111Obsessive-compulsive behavior (HP:0000722)1.78168606
112Preauricular skin tag (HP:0000384)1.77786003
113Abnormality of the duodenum (HP:0002246)1.77728678
114Pallor (HP:0000980)1.77592673
115Skull defect (HP:0001362)1.77371883
116Pointed chin (HP:0000307)1.76725114
117Intestinal polyp (HP:0005266)1.76399152
118Cutis marmorata (HP:0000965)1.76090197
119Abnormal gallbladder physiology (HP:0012438)1.76069473
120Cholecystitis (HP:0001082)1.76069473
121Ovarian neoplasm (HP:0100615)1.75703016
122Choanal atresia (HP:0000453)1.74846717
123Bowel diverticulosis (HP:0005222)1.74359368
124Abnormality of chromosome segregation (HP:0002916)1.74264320
125Neoplasm of the colon (HP:0100273)1.73444393
126Absent radius (HP:0003974)1.72924104
127Intestinal polyposis (HP:0200008)1.72138144
128Sloping forehead (HP:0000340)1.71504675
129Horseshoe kidney (HP:0000085)1.69240545
130Cellular immunodeficiency (HP:0005374)1.68545861
131Overriding aorta (HP:0002623)1.68422472
132Embryonal renal neoplasm (HP:0011794)1.68382481
133Abnormality of the salivary glands (HP:0010286)1.67877421
134Abnormality of reticulocytes (HP:0004312)1.67423727
135Abnormality of the umbilical cord (HP:0010881)1.67048493
136Trigonocephaly (HP:0000243)1.66752001
137Renovascular hypertension (HP:0100817)1.66158367
138Facial cleft (HP:0002006)1.64541718
139Deep philtrum (HP:0002002)1.63513534
140Premature graying of hair (HP:0002216)1.63377849
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.63268909
142Carpal bone hypoplasia (HP:0001498)1.62232187
143Vertebral arch anomaly (HP:0008438)1.62202801
144Ankle contracture (HP:0006466)1.62079253
145Calcaneovalgus deformity (HP:0001848)1.61782615
146Arnold-Chiari malformation (HP:0002308)1.61717636
147Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61445848
148Back pain (HP:0003418)1.61403062
149Flat cornea (HP:0007720)1.61231082
150Premature rupture of membranes (HP:0001788)1.60962697
151Orthostatic hypotension (HP:0001278)1.59908004
152Ragged-red muscle fibers (HP:0003200)1.59115561
153Leiomyosarcoma (HP:0100243)1.57807533
154Uterine leiomyosarcoma (HP:0002891)1.57807533
155Progressive hearing impairment (HP:0001730)1.57313870
156Unilateral renal agenesis (HP:0000122)1.55908873
157Heterotopia (HP:0002282)1.54295596
158Aplasia involving forearm bones (HP:0009822)1.54254902
159Absent forearm bone (HP:0003953)1.54254902
160Morphological abnormality of the inner ear (HP:0011390)1.52917164
161Microglossia (HP:0000171)1.52577342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.76373969
2SMG13.41562938
3BUB13.41011178
4EEF2K3.36072695
5WEE13.21501664
6NEK23.04704924
7PASK2.84077980
8PKN22.43656419
9MAP3K102.42869863
10CDK122.32754927
11TSSK62.32052164
12TESK22.10565803
13TTK2.05545549
14RPS6KB22.02352990
15TRIB31.93604643
16STK101.84199140
17MKNK11.84114763
18SRPK11.83753858
19NEK11.76749762
20ATR1.69710110
21EIF2AK11.67265428
22IRAK31.67105968
23TGFBR11.66383901
24PLK11.65339869
25VRK21.63709836
26MST1R1.61112987
27LATS21.60730957
28CDK41.58927589
29SCYL21.58765795
30AURKB1.58149770
31RPS6KA41.55569093
32MAP3K81.54895350
33BRSK21.49965549
34CDK71.48932908
35PBK1.45213723
36PRPF4B1.41972825
37TLK11.41932656
38PLK31.36449930
39PAK41.36092377
40LRRK21.35805834
41CHEK11.29399047
42BRD41.24284976
43ALK1.21578350
44MAP4K11.21565584
45CHEK21.17459295
46ACVR1B1.16713808
47CDK61.13316358
48DYRK31.10331091
49SIK11.09675400
50MKNK21.08269959
51TAF11.07996060
52BRSK11.05146698
53FLT30.99534401
54TESK10.97608290
55NME20.96308865
56AURKA0.95774466
57STK40.93982576
58CDK20.92622665
59EIF2AK30.92171978
60ATM0.91145292
61MELK0.90576035
62BRAF0.89990346
63PTK60.86788464
64MAP3K90.85667167
65PLK40.85008771
66VRK10.84387199
67MET0.84366099
68GRK60.84118225
69EPHA20.83153026
70TTN0.80944484
71CCNB10.80693646
72STK30.78314182
73KSR20.78263603
74MTOR0.75616289
75FGFR40.74935874
76CAMK1G0.71858173
77PAK20.70098705
78NTRK10.70072486
79ERBB40.68974253
80PIM10.68581652
81CDK10.68328376
82FGFR10.67249605
83CLK10.66552963
84CAMK1D0.66233038
85PTK20.63339603
86PNCK0.63136113
87MAP2K30.59742173
88CDK11A0.59305503
89PAK10.59255280
90CSNK2A20.58859282
91PDGFRA0.58486061
92ILK0.57072931
93RIPK10.55687982
94BTK0.55535985
95ARAF0.54337663
96CDK150.54273075
97ZAP700.53877946
98CDK80.52914935
99PRKD30.51764771
100CDK180.50977240
101NME10.49491083
102TYRO30.48759545
103AKT20.48201990
104CSF1R0.47403430
105KDR0.47063607
106BLK0.46344965
107CDK140.44844769
108CSNK1E0.43489657
109PRKDC0.43128964
110EIF2AK20.41458284
111* CSNK2A10.41214451
112BMX0.39986141
113TAOK20.38301808
114CDK90.37069877
115PRKCI0.36757185
116LATS10.34677854
117KSR10.34656154
118LIMK10.34487294
119DMPK0.34105203
120MAPK140.32329157
121CSNK1D0.31743291
122JAK30.29261067
123AKT10.27981678
124MAP3K30.24374335
125RPS6KA10.23878456
126ICK0.23550874
127ITK0.23192091
128MAPKAPK20.21654010
129RPS6KB10.21378461
130MAPK90.20683668
131MAPK10.20181073
132MAPK110.19985572

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.95483105
2Mismatch repair_Homo sapiens_hsa034304.10955980
3Spliceosome_Homo sapiens_hsa030403.45611068
4RNA transport_Homo sapiens_hsa030133.10606751
5Cell cycle_Homo sapiens_hsa041103.02361208
6Base excision repair_Homo sapiens_hsa034102.91992329
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91952394
8One carbon pool by folate_Homo sapiens_hsa006702.81917967
9Ribosome_Homo sapiens_hsa030102.63470844
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.62383772
11Nucleotide excision repair_Homo sapiens_hsa034202.57759029
12Homologous recombination_Homo sapiens_hsa034402.57669868
13Non-homologous end-joining_Homo sapiens_hsa034502.08033991
14mRNA surveillance pathway_Homo sapiens_hsa030152.07479730
15Proteasome_Homo sapiens_hsa030501.99721468
16RNA polymerase_Homo sapiens_hsa030201.94215989
17Fanconi anemia pathway_Homo sapiens_hsa034601.89756629
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75612968
19RNA degradation_Homo sapiens_hsa030181.73122074
20Pyrimidine metabolism_Homo sapiens_hsa002401.71637139
21p53 signaling pathway_Homo sapiens_hsa041151.57398791
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38304652
23Antigen processing and presentation_Homo sapiens_hsa046121.36130012
24Viral carcinogenesis_Homo sapiens_hsa052031.34709229
25Systemic lupus erythematosus_Homo sapiens_hsa053221.28267640
26Basal transcription factors_Homo sapiens_hsa030221.24568276
27Epstein-Barr virus infection_Homo sapiens_hsa051691.22360942
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20261569
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18616341
30HTLV-I infection_Homo sapiens_hsa051661.16536906
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13285756
32MicroRNAs in cancer_Homo sapiens_hsa052061.11630468
33Oocyte meiosis_Homo sapiens_hsa041141.10048742
34Chronic myeloid leukemia_Homo sapiens_hsa052201.06830758
35Vitamin B6 metabolism_Homo sapiens_hsa007501.05237342
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03886667
37Small cell lung cancer_Homo sapiens_hsa052221.03242610
38Herpes simplex infection_Homo sapiens_hsa051681.01932703
39Pyruvate metabolism_Homo sapiens_hsa006200.99372185
40Colorectal cancer_Homo sapiens_hsa052100.94408985
41Thyroid cancer_Homo sapiens_hsa052160.94143698
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90648430
43Primary immunodeficiency_Homo sapiens_hsa053400.89765958
44Sulfur relay system_Homo sapiens_hsa041220.87312417
45Basal cell carcinoma_Homo sapiens_hsa052170.86237933
46Fructose and mannose metabolism_Homo sapiens_hsa000510.85305018
47Hippo signaling pathway_Homo sapiens_hsa043900.79853573
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77961578
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77289433
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.76468655
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75638352
52Selenocompound metabolism_Homo sapiens_hsa004500.75064171
53Bladder cancer_Homo sapiens_hsa052190.74861510
54Purine metabolism_Homo sapiens_hsa002300.74131449
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74027828
56Viral myocarditis_Homo sapiens_hsa054160.73748509
57Notch signaling pathway_Homo sapiens_hsa043300.71745392
58Adherens junction_Homo sapiens_hsa045200.71385043
59Hepatitis B_Homo sapiens_hsa051610.70757328
60Biosynthesis of amino acids_Homo sapiens_hsa012300.70750497
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.69144504
62TGF-beta signaling pathway_Homo sapiens_hsa043500.69120039
63Non-small cell lung cancer_Homo sapiens_hsa052230.67748569
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66350166
65Renal cell carcinoma_Homo sapiens_hsa052110.65910251
66Folate biosynthesis_Homo sapiens_hsa007900.65882338
67Legionellosis_Homo sapiens_hsa051340.63943522
68Prion diseases_Homo sapiens_hsa050200.63799770
69ErbB signaling pathway_Homo sapiens_hsa040120.63572858
70Apoptosis_Homo sapiens_hsa042100.63540823
71Shigellosis_Homo sapiens_hsa051310.63334499
72Galactose metabolism_Homo sapiens_hsa000520.62983711
73Pancreatic cancer_Homo sapiens_hsa052120.62031249
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61700136
75Alcoholism_Homo sapiens_hsa050340.61381594
76N-Glycan biosynthesis_Homo sapiens_hsa005100.61287413
77mTOR signaling pathway_Homo sapiens_hsa041500.56627116
78Proteoglycans in cancer_Homo sapiens_hsa052050.56374406
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56035880
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55347832
81Insulin signaling pathway_Homo sapiens_hsa049100.55026107
82Pentose phosphate pathway_Homo sapiens_hsa000300.53760078
83Hedgehog signaling pathway_Homo sapiens_hsa043400.53235860
84Measles_Homo sapiens_hsa051620.53235257
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52172957
86Pathways in cancer_Homo sapiens_hsa052000.51830231
87Acute myeloid leukemia_Homo sapiens_hsa052210.51286674
88Prostate cancer_Homo sapiens_hsa052150.50566076
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50532703
90B cell receptor signaling pathway_Homo sapiens_hsa046620.49811182
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.47995655
92HIF-1 signaling pathway_Homo sapiens_hsa040660.47409191
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.46609841
94AMPK signaling pathway_Homo sapiens_hsa041520.45743099
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45317933
96Endometrial cancer_Homo sapiens_hsa052130.45044990
97T cell receptor signaling pathway_Homo sapiens_hsa046600.44744411
98Lysine degradation_Homo sapiens_hsa003100.43580240
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43156408
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41862706
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41725078
102Wnt signaling pathway_Homo sapiens_hsa043100.39165303
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38419068
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.37941429
105Arginine biosynthesis_Homo sapiens_hsa002200.36780337
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.36623385
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35185864
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35101331
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34861416
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33626480
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33380622
112Melanogenesis_Homo sapiens_hsa049160.32913763
113Focal adhesion_Homo sapiens_hsa045100.32399796
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32323024
115VEGF signaling pathway_Homo sapiens_hsa043700.31525065
116Carbon metabolism_Homo sapiens_hsa012000.28692259
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27449760
118Tight junction_Homo sapiens_hsa045300.27169557
119Glioma_Homo sapiens_hsa052140.26641316
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26234637
121Influenza A_Homo sapiens_hsa051640.25000402
122Melanoma_Homo sapiens_hsa052180.24901818
123Hematopoietic cell lineage_Homo sapiens_hsa046400.24341652
124Platelet activation_Homo sapiens_hsa046110.23168532
125Toxoplasmosis_Homo sapiens_hsa051450.22527932

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