SST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.16209529
2regulation of glucokinase activity (GO:0033131)5.98620434
3regulation of hexokinase activity (GO:1903299)5.98620434
4regulation of type B pancreatic cell apoptotic process (GO:2000674)5.74588284
5positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.61048190
6response to pheromone (GO:0019236)5.38236500
7COPI coating of Golgi vesicle (GO:0048205)5.37758363
8Golgi transport vesicle coating (GO:0048200)5.37758363
9L-fucose catabolic process (GO:0042355)5.05897142
10fucose catabolic process (GO:0019317)5.05897142
11L-fucose metabolic process (GO:0042354)5.05897142
12adult feeding behavior (GO:0008343)4.97997691
13detection of calcium ion (GO:0005513)4.86180363
14cellular ketone body metabolic process (GO:0046950)4.85747469
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.80810385
16aggressive behavior (GO:0002118)4.80330942
17embryonic retina morphogenesis in camera-type eye (GO:0060059)4.75101731
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69650289
19behavioral response to ethanol (GO:0048149)4.68866077
20exogenous drug catabolic process (GO:0042738)4.65899677
21positive regulation of mitochondrial fission (GO:0090141)4.59563910
22glycerophospholipid catabolic process (GO:0046475)4.54919481
23protein localization to cilium (GO:0061512)4.52947904
24negative regulation of gluconeogenesis (GO:0045721)4.50759061
25regulation of neurotransmitter uptake (GO:0051580)4.34542067
26startle response (GO:0001964)4.34399612
27ketone body metabolic process (GO:1902224)4.29256513
28neuron cell-cell adhesion (GO:0007158)4.24600893
29pigment granule transport (GO:0051904)4.22432426
30pyrimidine nucleobase catabolic process (GO:0006208)4.17525929
31establishment of pigment granule localization (GO:0051905)4.11131847
32succinate metabolic process (GO:0006105)4.07448707
33nucleobase catabolic process (GO:0046113)4.01708394
34regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.00982124
35regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.00982124
36auditory receptor cell differentiation (GO:0042491)3.94903307
37endocrine pancreas development (GO:0031018)3.93059880
38detection of light stimulus involved in sensory perception (GO:0050962)3.92915223
39detection of light stimulus involved in visual perception (GO:0050908)3.92915223
40regulation of synaptic vesicle exocytosis (GO:2000300)3.88503081
41synaptic vesicle exocytosis (GO:0016079)3.86082334
42positive regulation of synaptic transmission, GABAergic (GO:0032230)3.84508842
43activation of protein kinase A activity (GO:0034199)3.84255164
44regulation of glutamate receptor signaling pathway (GO:1900449)3.81808751
45phenylpropanoid metabolic process (GO:0009698)3.76757793
46melanosome transport (GO:0032402)3.73940262
47drug catabolic process (GO:0042737)3.69747748
48protein K6-linked ubiquitination (GO:0085020)3.69624253
49pigment granule localization (GO:0051875)3.68477722
50energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.68078553
51ATP hydrolysis coupled proton transport (GO:0015991)3.68078553
52synaptic transmission, dopaminergic (GO:0001963)3.67747198
53glandular epithelial cell development (GO:0002068)3.64695539
54establishment of melanosome localization (GO:0032401)3.64330209
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63450886
56type B pancreatic cell development (GO:0003323)3.62732125
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61888945
58L-phenylalanine catabolic process (GO:0006559)3.61888945
59synaptic vesicle maturation (GO:0016188)3.61712259
60peptide hormone processing (GO:0016486)3.61241238
61regulation of beta-amyloid formation (GO:1902003)3.59429980
62gamma-aminobutyric acid transport (GO:0015812)3.59022821
63dopamine transport (GO:0015872)3.57559900
64locomotory exploration behavior (GO:0035641)3.53692767
65negative regulation of JAK-STAT cascade (GO:0046426)3.53609468
66epithelial cell fate commitment (GO:0072148)3.52952791
67dicarboxylic acid catabolic process (GO:0043649)3.50345325
68nitric oxide mediated signal transduction (GO:0007263)3.49932499
69vocalization behavior (GO:0071625)3.49306954
70catecholamine transport (GO:0051937)3.47874271
71cellular response to glucagon stimulus (GO:0071377)3.43325262
72positive regulation of response to extracellular stimulus (GO:0032106)3.42962841
73positive regulation of response to nutrient levels (GO:0032109)3.42962841
74transferrin transport (GO:0033572)3.37945974
75positive regulation of amine transport (GO:0051954)3.35406961
76negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34369973
77regulation of response to food (GO:0032095)3.31374154
78poly(A)+ mRNA export from nucleus (GO:0016973)3.30581250
79regulation of synaptic vesicle transport (GO:1902803)3.24103038
80melanosome localization (GO:0032400)3.23798966
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22084273
82xenobiotic catabolic process (GO:0042178)3.22008009
83trivalent inorganic cation transport (GO:0072512)3.21854173
84ferric iron transport (GO:0015682)3.21854173
85regulation of mitochondrial fission (GO:0090140)3.21694956
86exploration behavior (GO:0035640)3.19210419
87regulation of synaptic transmission, dopaminergic (GO:0032225)3.18303223
88insulin secretion (GO:0030073)3.16798577
89regulation of short-term neuronal synaptic plasticity (GO:0048172)3.16631799
90positive regulation of insulin secretion (GO:0032024)3.14926220
91peptidyl-cysteine modification (GO:0018198)3.12919886
92intraciliary transport (GO:0042073)3.12720265
93parturition (GO:0007567)3.11371060
94neurotransmitter secretion (GO:0007269)3.11366264
95phagosome maturation (GO:0090382)3.10356553
96positive regulation of amino acid transport (GO:0051957)3.08820755
97positive regulation of membrane potential (GO:0045838)3.08717569
98neurotransmitter uptake (GO:0001504)3.06955831
99retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.06785539
100glandular epithelial cell differentiation (GO:0002067)3.06234871
101positive regulation of action potential (GO:0045760)3.06198469
102protein localization to synapse (GO:0035418)3.05828652
103negative regulation of cAMP-mediated signaling (GO:0043951)3.04030938
104innervation (GO:0060384)3.03600976
105oxaloacetate metabolic process (GO:0006107)3.00150965
106cerebellar Purkinje cell layer development (GO:0021680)2.98207390
107NADH metabolic process (GO:0006734)2.97532369
108positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97151207
109norepinephrine metabolic process (GO:0042415)2.97056649
110negative regulation of telomere maintenance (GO:0032205)2.96675711
111regulation of insulin secretion (GO:0050796)2.95829080
112regulation of amyloid precursor protein catabolic process (GO:1902991)2.95354339
113regulation of mitochondrial translation (GO:0070129)2.95129136
114protein-cofactor linkage (GO:0018065)2.94918861
115regulation of vesicle fusion (GO:0031338)2.94612392
116plasma membrane fusion (GO:0045026)2.94396557
117L-phenylalanine metabolic process (GO:0006558)2.94182412
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.94182412
119calcium ion import (GO:0070509)2.93714311
120cellular response to ammonium ion (GO:0071242)2.93642489
121regulation of calcium ion-dependent exocytosis (GO:0017158)2.93389712
122neuron-neuron synaptic transmission (GO:0007270)2.93085648
123negative regulation of receptor activity (GO:2000272)2.92746371
124negative regulation of neurotransmitter transport (GO:0051589)2.91495728
125positive regulation of exocytosis (GO:0045921)2.91184854
126dentate gyrus development (GO:0021542)2.89345679
127positive regulation of transcription regulatory region DNA binding (GO:2000679)2.89246848
128neurotransmitter biosynthetic process (GO:0042136)2.88854523
129neuromuscular process controlling posture (GO:0050884)2.86974062
130regulation of exocytosis (GO:0017157)2.86332437
131regulation of peptide hormone secretion (GO:0090276)2.84064218
132uterus development (GO:0060065)2.83932989
133positive regulation of guanylate cyclase activity (GO:0031284)2.82591290
134L-alpha-amino acid transmembrane transport (GO:1902475)2.82190019
135ER overload response (GO:0006983)2.81678558
136negative regulation of peptide hormone secretion (GO:0090278)2.81356905
137ionotropic glutamate receptor signaling pathway (GO:0035235)2.81023155
138establishment of mitochondrion localization (GO:0051654)2.79483564
139transmission of nerve impulse (GO:0019226)2.79436851
140regulation of peptide secretion (GO:0002791)2.79154549
141vesicle coating (GO:0006901)2.78503489
142dendritic spine morphogenesis (GO:0060997)2.77789421
143chemosensory behavior (GO:0007635)2.76023167
144regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75416153
145glutamate secretion (GO:0014047)2.75292397
146regulation of appetite (GO:0032098)2.74174075
147fucosylation (GO:0036065)2.73966395
148regulation of neurotransmitter levels (GO:0001505)2.73243535
149water-soluble vitamin biosynthetic process (GO:0042364)2.72198098
150growth hormone secretion (GO:0030252)2.72177633
151glycosphingolipid biosynthetic process (GO:0006688)2.71893915
152synaptic transmission, glutamatergic (GO:0035249)2.71566288
153COPII vesicle coating (GO:0048208)2.71328276
154righting reflex (GO:0060013)2.71147803
155response to histamine (GO:0034776)2.71034869
156negative regulation of calcium ion transport into cytosol (GO:0010523)2.70994089
157neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.70907015
158protein maturation by protein folding (GO:0022417)2.70879443
159negative regulation of peptide secretion (GO:0002792)2.70798015
160positive regulation of receptor recycling (GO:0001921)2.70248545
161neuronal action potential propagation (GO:0019227)2.69457646
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68987186
163zinc ion homeostasis (GO:0055069)2.68827271
164positive regulation of neurotransmitter transport (GO:0051590)2.68482590
165regulation of cAMP-dependent protein kinase activity (GO:2000479)2.68132719
166proline transport (GO:0015824)2.67871187
167cochlea development (GO:0090102)2.67416306
168axoneme assembly (GO:0035082)2.67003336
169mitochondrial calcium ion transport (GO:0006851)2.66971821
170synapse assembly (GO:0007416)2.66197178
171platelet dense granule organization (GO:0060155)2.65421755
172genitalia morphogenesis (GO:0035112)2.64914675
173astrocyte differentiation (GO:0048708)2.63924961
174substrate-independent telencephalic tangential migration (GO:0021826)2.62740273
175substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.62740273
176response to dietary excess (GO:0002021)2.62142741
177maintenance of gastrointestinal epithelium (GO:0030277)2.61391779
178negative regulation of heart growth (GO:0061117)2.60900180
179negative regulation of cardiac muscle tissue growth (GO:0055022)2.60900180
180positive regulation of peptide hormone secretion (GO:0090277)2.60279392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.49741041
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.36673795
3GBX2_23144817_ChIP-Seq_PC3_Human3.65684905
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.29206421
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88785473
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74957125
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.61218843
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44773729
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43917305
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42959524
11IRF1_19129219_ChIP-ChIP_H3396_Human2.37995245
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.36756696
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35691914
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33997320
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27167824
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23791990
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22309205
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21976657
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20077360
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19787525
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19468746
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.19362814
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16946995
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16946995
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07391070
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97254847
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93017828
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90655721
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87135330
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82198611
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.81961226
32TAF15_26573619_Chip-Seq_HEK293_Human1.78990159
33SMAD4_21799915_ChIP-Seq_A2780_Human1.78454186
34AR_21572438_ChIP-Seq_LNCaP_Human1.77171636
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75862408
36P300_19829295_ChIP-Seq_ESCs_Human1.73286781
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.72032707
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71628871
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.71368016
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66294810
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63013688
42ZNF274_21170338_ChIP-Seq_K562_Hela1.62184774
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59025934
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.57916552
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55348714
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.55328014
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53808858
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.53268418
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52882071
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51485598
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50438028
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49291571
53VDR_22108803_ChIP-Seq_LS180_Human1.46403855
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.43968161
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43915886
56FUS_26573619_Chip-Seq_HEK293_Human1.43365583
57* DROSHA_22980978_ChIP-Seq_HELA_Human1.35592617
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.34735735
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34406484
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.30191713
61STAT3_23295773_ChIP-Seq_U87_Human1.29805904
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29425810
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25410977
64EWS_26573619_Chip-Seq_HEK293_Human1.24963702
65RNF2_27304074_Chip-Seq_NSC_Mouse1.23304498
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22285910
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20264011
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18459897
69* PRDM14_20953172_ChIP-Seq_ESCs_Human1.18093935
70NCOR_22424771_ChIP-Seq_293T_Human1.16910513
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16673690
72AR_25329375_ChIP-Seq_VCAP_Human1.16059501
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15955527
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13487566
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13273320
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.13150854
77REST_19997604_ChIP-ChIP_NEURONS_Mouse1.11610658
78ER_23166858_ChIP-Seq_MCF-7_Human1.11191930
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11189979
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11189979
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10976714
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10816308
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09764679
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08250139
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07544704
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07325237
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06569749
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.06267283
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06171943
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05860263
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.05602381
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05445662
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05184960
94MYC_19829295_ChIP-Seq_ESCs_Human1.04739500
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04265130
96SMAD3_21741376_ChIP-Seq_ESCs_Human1.04013111
97TP53_18474530_ChIP-ChIP_U2OS_Human1.02041285
98* TCF4_22108803_ChIP-Seq_LS180_Human0.99550489
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99473805
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.99090671
101HTT_18923047_ChIP-ChIP_STHdh_Human0.98696158
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98409653
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98409653
104TCF4_23295773_ChIP-Seq_U87_Human0.96497464
105TP53_22573176_ChIP-Seq_HFKS_Human0.96385173
106* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95966347
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.95619594
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94793086
109* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93775807
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93385933
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92909115
112FOXA1_25329375_ChIP-Seq_VCAP_Human0.91491546
113FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91491546
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91347215
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90744633
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90679685
117CBP_20019798_ChIP-Seq_JUKART_Human0.90408092
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90408092
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90386948
120IGF1R_20145208_ChIP-Seq_DFB_Human0.89670424
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89225991
122* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89142082
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88262976
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87917921
125AHR_22903824_ChIP-Seq_MCF-7_Human0.87578281
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86501766
127EST1_17652178_ChIP-ChIP_JURKAT_Human0.86216307
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86014673
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.85890739
130* BCAT_22108803_ChIP-Seq_LS180_Human0.84172333
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84137503
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.84054492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.33699579
2MP0005645_abnormal_hypothalamus_physiol4.93398054
3MP0003122_maternal_imprinting3.42210289
4MP0002909_abnormal_adrenal_gland3.10747407
5MP0003183_abnormal_peptide_metabolism3.09558810
6MP0002837_dystrophic_cardiac_calcinosis2.98060347
7MP0004043_abnormal_pH_regulation2.68322943
8MP0001529_abnormal_vocalization2.62630065
9MP0005187_abnormal_penis_morphology2.48101756
10MP0001501_abnormal_sleep_pattern2.46876648
11MP0004859_abnormal_synaptic_plasticity2.46105330
12MP0004147_increased_porphyrin_level2.44839692
13MP0010386_abnormal_urinary_bladder2.39275417
14MP0003787_abnormal_imprinting2.33554974
15* MP0003635_abnormal_synaptic_transmissio2.32030525
16MP0005379_endocrine/exocrine_gland_phen2.29701203
17MP0003195_calcinosis2.24719163
18MP0002064_seizures2.20420909
19MP0004270_analgesia2.16241603
20MP0009780_abnormal_chondrocyte_physiolo2.15503733
21MP0000372_irregular_coat_pigmentation2.09780279
22MP0009046_muscle_twitch2.09472495
23MP0005423_abnormal_somatic_nervous2.01930637
24* MP0002272_abnormal_nervous_system2.01788819
25MP0003283_abnormal_digestive_organ1.98103587
26MP0002693_abnormal_pancreas_physiology1.96393737
27MP0009745_abnormal_behavioral_response1.95391850
28MP0004885_abnormal_endolymph1.95199433
29MP0002572_abnormal_emotion/affect_behav1.92509204
30MP0002638_abnormal_pupillary_reflex1.91872720
31MP0000003_abnormal_adipose_tissue1.88254940
32MP0003646_muscle_fatigue1.83975848
33MP0001188_hyperpigmentation1.82100419
34MP0002063_abnormal_learning/memory/cond1.80192841
35MP0002734_abnormal_mechanical_nocicepti1.79137183
36MP0001944_abnormal_pancreas_morphology1.78544342
37MP0008877_abnormal_DNA_methylation1.76745274
38MP0002928_abnormal_bile_duct1.70527135
39MP0001440_abnormal_grooming_behavior1.69804288
40MP0004858_abnormal_nervous_system1.69414043
41MP0002090_abnormal_vision1.69002095
42MP0005551_abnormal_eye_electrophysiolog1.63789108
43MP0001986_abnormal_taste_sensitivity1.60644551
44MP0003959_abnormal_lean_body1.57950777
45MP0002735_abnormal_chemical_nociception1.54978901
46MP0004036_abnormal_muscle_relaxation1.53343520
47MP0004084_abnormal_cardiac_muscle1.52031116
48MP0002163_abnormal_gland_morphology1.48922704
49MP0001905_abnormal_dopamine_level1.46031705
50MP0002822_catalepsy1.43162833
51MP0002102_abnormal_ear_morphology1.42195065
52MP0008961_abnormal_basal_metabolism1.41703107
53MP0000639_abnormal_adrenal_gland1.40615751
54MP0002078_abnormal_glucose_homeostasis1.38197421
55MP0001970_abnormal_pain_threshold1.36848376
56MP0001661_extended_life_span1.36735393
57MP0005253_abnormal_eye_physiology1.33948116
58MP0006276_abnormal_autonomic_nervous1.33657799
59MP0001968_abnormal_touch/_nociception1.32762114
60MP0003045_fibrosis1.32271328
61MP0002736_abnormal_nociception_after1.31983960
62MP0006292_abnormal_olfactory_placode1.31500151
63MP0004233_abnormal_muscle_weight1.29794563
64MP0003866_abnormal_defecation1.29398366
65MP0002557_abnormal_social/conspecific_i1.28173038
66MP0005646_abnormal_pituitary_gland1.27937618
67MP0002876_abnormal_thyroid_physiology1.27825215
68MP0003123_paternal_imprinting1.26674839
69MP0002733_abnormal_thermal_nociception1.26605097
70MP0003880_abnormal_central_pattern1.25390289
71MP0003121_genomic_imprinting1.24857605
72MP0006036_abnormal_mitochondrial_physio1.23852176
73MP0005167_abnormal_blood-brain_barrier1.23827283
74MP0005535_abnormal_body_temperature1.23763090
75MP0010329_abnormal_lipoprotein_level1.23305153
76MP0001485_abnormal_pinna_reflex1.21736458
77MP0003011_delayed_dark_adaptation1.20817317
78MP0003172_abnormal_lysosome_physiology1.20142847
79MP0003329_amyloid_beta_deposits1.17803937
80MP0006072_abnormal_retinal_apoptosis1.16691081
81MP0002229_neurodegeneration1.15871014
82MP0002184_abnormal_innervation1.13765153
83MP0005266_abnormal_metabolism1.12336779
84MP0002069_abnormal_eating/drinking_beha1.11872469
85MP0001984_abnormal_olfaction1.11240986
86MP0003136_yellow_coat_color1.09742029
87MP0001756_abnormal_urination1.09247322
88MP0002877_abnormal_melanocyte_morpholog1.08127902
89MP0004924_abnormal_behavior1.07475730
90MP0005386_behavior/neurological_phenoty1.07475730
91MP0001486_abnormal_startle_reflex1.07442546
92MP0005377_hearing/vestibular/ear_phenot1.06173978
93MP0003878_abnormal_ear_physiology1.06173978
94MP0002067_abnormal_sensory_capabilities1.04776510
95MP0004019_abnormal_vitamin_homeostasis1.03945224
96* MP0001664_abnormal_digestion1.02108494
97MP0000955_abnormal_spinal_cord1.01894358
98MP0001764_abnormal_homeostasis1.01059981
99MP0005448_abnormal_energy_balance0.99890039
100MP0001502_abnormal_circadian_rhythm0.99588796
101MP0005332_abnormal_amino_acid0.96933573
102MP0000678_abnormal_parathyroid_gland0.95827810
103MP0000631_abnormal_neuroendocrine_gland0.94785942
104MP0004811_abnormal_neuron_physiology0.94373705
105MP0002332_abnormal_exercise_endurance0.93751262
106MP0003879_abnormal_hair_cell0.91508697
107MP0000750_abnormal_muscle_regeneration0.91162274
108MP0005257_abnormal_intraocular_pressure0.90615349
109MP0004085_abnormal_heartbeat0.87607393
110MP0001765_abnormal_ion_homeostasis0.85249982
111MP0003953_abnormal_hormone_level0.83479942
112MP0002066_abnormal_motor_capabilities/c0.83455143
113MP0000778_abnormal_nervous_system0.82505993
114MP0000230_abnormal_systemic_arterial0.82422992
115MP0004134_abnormal_chest_morphology0.81852989
116MP0008872_abnormal_physiological_respon0.80799387
117MP0003567_abnormal_fetal_cardiomyocyte0.80470600
118MP0005174_abnormal_tail_pigmentation0.80339309
119MP0000751_myopathy0.79308758
120MP0003119_abnormal_digestive_system0.77899707
121MP0001963_abnormal_hearing_physiology0.76814489
122MP0005220_abnormal_exocrine_pancreas0.76265539
123MP0008995_early_reproductive_senescence0.74778265
124MP0002882_abnormal_neuron_morphology0.73157855
125MP0004142_abnormal_muscle_tone0.72848500
126MP0008569_lethality_at_weaning0.71211214
127MP0005084_abnormal_gallbladder_morpholo0.71150027
128MP0005670_abnormal_white_adipose0.69525235
129MP0008775_abnormal_heart_ventricle0.68767978
130MP0002896_abnormal_bone_mineralization0.67997371
131MP0005058_abnormal_lysosome_morphology0.67513978
132MP0003633_abnormal_nervous_system0.67407736
133MP0003638_abnormal_response/metabolism_0.67368440
134MP0002234_abnormal_pharynx_morphology0.65972484
135MP0004264_abnormal_extraembryonic_tissu0.65348072
136MP0004883_abnormal_blood_vessel0.65317777
137MP0005499_abnormal_olfactory_system0.64712796
138MP0005394_taste/olfaction_phenotype0.64712796
139MP0002168_other_aberrant_phenotype0.64690315

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.17549848
2Hyperinsulinemic hypoglycemia (HP:0000825)4.70059948
3Retinal atrophy (HP:0001105)4.66230484
4Arthropathy (HP:0003040)4.56128205
5Neuroendocrine neoplasm (HP:0100634)4.52662222
6Abnormal hair whorl (HP:0010721)4.52304960
7Wrist flexion contracture (HP:0001239)4.41096118
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14570801
9Symptomatic seizures (HP:0011145)4.06106804
10Agitation (HP:0000713)4.03631882
11Abnormality of calcium-phosphate metabolism (HP:0100530)3.95510864
12Pheochromocytoma (HP:0002666)3.91078817
13Hypomagnesemia (HP:0002917)3.85081192
14Hypoglycemic seizures (HP:0002173)3.74698297
15Visual hallucinations (HP:0002367)3.59099270
16Focal motor seizures (HP:0011153)3.56086105
17Failure to thrive in infancy (HP:0001531)3.48361914
18Oligomenorrhea (HP:0000876)3.48262840
19Pancreatic islet-cell hyperplasia (HP:0004510)3.47681884
20Atonic seizures (HP:0010819)3.43253526
21Abnormality of magnesium homeostasis (HP:0004921)3.29864004
22Acute necrotizing encephalopathy (HP:0006965)3.21541221
23Sex reversal (HP:0012245)3.19998792
24Abnormal sex determination (HP:0012244)3.19998792
25Abnormality of the fovea (HP:0000493)3.17830119
26Insulin-resistant diabetes mellitus (HP:0000831)3.17302905
27Absence seizures (HP:0002121)3.10227534
28Hyperglycemia (HP:0003074)3.05964916
29Papilledema (HP:0001085)3.04803674
30Anterior segment dysgenesis (HP:0007700)3.04550964
31Epileptiform EEG discharges (HP:0011182)2.98865697
32Abnormal mitochondria in muscle tissue (HP:0008316)2.98657755
33EEG with generalized epileptiform discharges (HP:0011198)2.97672236
34Abnormality of the pancreatic islet cells (HP:0006476)2.96460339
35Abnormality of endocrine pancreas physiology (HP:0012093)2.96460339
36Generalized tonic-clonic seizures (HP:0002069)2.94141298
37Hypsarrhythmia (HP:0002521)2.91043717
38Ketoacidosis (HP:0001993)2.90621479
39Osteomalacia (HP:0002749)2.89985653
40Abnormality of macular pigmentation (HP:0008002)2.87771551
41Congenital primary aphakia (HP:0007707)2.86638005
42Resting tremor (HP:0002322)2.85653074
43Adrenal hypoplasia (HP:0000835)2.83773554
44Anxiety (HP:0000739)2.81501735
45Congenital glaucoma (HP:0001087)2.78753181
46Large for gestational age (HP:0001520)2.76470950
47Delayed puberty (HP:0000823)2.75919586
48Hypoglycemic coma (HP:0001325)2.75428413
49Progressive macrocephaly (HP:0004481)2.74987439
50Focal seizures (HP:0007359)2.73888714
51Abolished electroretinogram (ERG) (HP:0000550)2.73295319
52Dysostosis multiplex (HP:0000943)2.68490251
53Polyphagia (HP:0002591)2.63727492
54Myokymia (HP:0002411)2.63707988
55Acute encephalopathy (HP:0006846)2.58143753
56Nephrogenic diabetes insipidus (HP:0009806)2.56531842
57Dialeptic seizures (HP:0011146)2.54180837
58Late onset (HP:0003584)2.51795687
59Vaginal atresia (HP:0000148)2.49079416
60Spastic tetraplegia (HP:0002510)2.45980057
61Genital tract atresia (HP:0001827)2.42570029
62Bilateral sensorineural hearing impairment (HP:0008619)2.41043077
63Abnormal ciliary motility (HP:0012262)2.39717968
64Hypoventilation (HP:0002791)2.39550178
65Progressive neurologic deterioration (HP:0002344)2.39193314
66Skin nodule (HP:0200036)2.38717197
67Ketosis (HP:0001946)2.34524596
68Hepatoblastoma (HP:0002884)2.33513035
69Abnormality of the labia minora (HP:0012880)2.30655709
70Genetic anticipation (HP:0003743)2.30619886
71Growth hormone deficiency (HP:0000824)2.29465007
72Abnormal respiratory epithelium morphology (HP:0012253)2.29426951
73Abnormal respiratory motile cilium morphology (HP:0005938)2.29426951
74Mitochondrial inheritance (HP:0001427)2.29366438
75Psychosis (HP:0000709)2.29258860
76Broad face (HP:0000283)2.28839299
77Narrow nasal bridge (HP:0000446)2.26531564
78Hyperphosphaturia (HP:0003109)2.26260250
79Neoplasm of the peripheral nervous system (HP:0100007)2.24685271
80Hypokalemia (HP:0002900)2.24049526
81Type II lissencephaly (HP:0007260)2.22041037
82Restlessness (HP:0000711)2.22011895
83Postural tremor (HP:0002174)2.21653273
84Impaired vibration sensation in the lower limbs (HP:0002166)2.17207627
85Prominent metopic ridge (HP:0005487)2.14779762
86Sensorimotor neuropathy (HP:0007141)2.14087679
87Hyperparathyroidism (HP:0000843)2.14012115
88Abnormal rod and cone electroretinograms (HP:0008323)2.13539311
89Congenital sensorineural hearing impairment (HP:0008527)2.13531969
90Hypogonadotrophic hypogonadism (HP:0000044)2.12249780
91Abnormal drinking behavior (HP:0030082)2.12179550
92Polydipsia (HP:0001959)2.12179550
93Progressive cerebellar ataxia (HP:0002073)2.11165200
94Prominent supraorbital ridges (HP:0000336)2.09938573
95Neoplasm of the tracheobronchial system (HP:0100552)2.08885176
96Poor suck (HP:0002033)2.07920406
97Epileptic encephalopathy (HP:0200134)2.05741981
98Shoulder girdle muscle weakness (HP:0003547)2.05480744
99Buphthalmos (HP:0000557)2.05435876
100Abnormality of the vocal cords (HP:0008777)2.05239847
101Decreased circulating renin level (HP:0003351)2.04249251
102Abnormal eating behavior (HP:0100738)2.02537041
103Absent eyebrow (HP:0002223)2.02462920
104Sleep apnea (HP:0010535)2.02117897
105Hepatic necrosis (HP:0002605)2.02059533
106Tachypnea (HP:0002789)2.01476207
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01195953
108Unilateral renal agenesis (HP:0000122)2.00891734
109Bony spicule pigmentary retinopathy (HP:0007737)2.00838232
110Hypothermia (HP:0002045)2.00788232
111Abnormality of pain sensation (HP:0010832)1.99710128
112Impaired pain sensation (HP:0007328)1.99710128
113Azoospermia (HP:0000027)1.99209731
114Macroorchidism (HP:0000053)1.98375295
115Gait imbalance (HP:0002141)1.96771083
116Congenital stationary night blindness (HP:0007642)1.96094795
117Renal salt wasting (HP:0000127)1.95744823
118Aplasia/Hypoplasia of the macula (HP:0008059)1.95137129
119Tetany (HP:0001281)1.94900032
120Gout (HP:0001997)1.94681225
121Intestinal atresia (HP:0011100)1.94027205
122Tubulointerstitial nephritis (HP:0001970)1.94027052
123Labial hypoplasia (HP:0000066)1.93141090
124Lissencephaly (HP:0001339)1.91721176
125Abnormality of the hip-girdle musculature (HP:0001445)1.90770977
126Abnormality of the musculature of the pelvis (HP:0001469)1.90770977
127Depression (HP:0000716)1.90569158
1283-Methylglutaconic aciduria (HP:0003535)1.90424218
129Renal Fanconi syndrome (HP:0001994)1.89916291
130Torticollis (HP:0000473)1.89567341
131Abnormal pupillary function (HP:0007686)1.89528727
132Poor coordination (HP:0002370)1.89453154
133Broad-based gait (HP:0002136)1.89017797
134Polyuria (HP:0000103)1.89003584
135Rhinitis (HP:0012384)1.88870220
136Mesomelia (HP:0003027)1.88751337
137Hyperventilation (HP:0002883)1.87417483
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.87333180
139Absent/shortened dynein arms (HP:0200106)1.87333180
140Retinitis pigmentosa (HP:0000510)1.87188678
141Hyperphosphatemia (HP:0002905)1.85793073
142Specific learning disability (HP:0001328)1.85071329
143Abnormal pancreas size (HP:0012094)1.84980514
144Muscular hypotonia of the trunk (HP:0008936)1.84964049
145Generalized hypopigmentation (HP:0007513)1.84386916
146Drooling (HP:0002307)1.84345633
147Excessive salivation (HP:0003781)1.84345633
148Retinal dysplasia (HP:0007973)1.83756193
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.83237795
150Hypoplasia of the fovea (HP:0007750)1.83237795
151Short foot (HP:0001773)1.82626856
152Tinnitus (HP:0000360)1.82616352
153Abnormal urine phosphate concentration (HP:0012599)1.82235252
154Increased circulating renin level (HP:0000848)1.81693754
155Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81389232
156Abnormality of the diencephalon (HP:0010662)1.80173101
157Neuronal loss in central nervous system (HP:0002529)1.80019705
158Zonular cataract (HP:0010920)1.79881166
159Abnormality of dental color (HP:0011073)1.79772159
160Medial flaring of the eyebrow (HP:0010747)1.78394831
161Febrile seizures (HP:0002373)1.78205988
162Focal dystonia (HP:0004373)1.74406301
163Attenuation of retinal blood vessels (HP:0007843)1.73172421
164Abnormality of renin-angiotensin system (HP:0000847)1.73151235
165Absent speech (HP:0001344)1.72789377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.92692132
2TAOK34.37457883
3PIK3CG3.82310200
4INSRR3.52948198
5NTRK32.96170219
6HIPK22.65242606
7MAP3K42.62939671
8UHMK12.56448388
9MAP2K72.50514600
10CASK2.37015660
11PNCK2.36957395
12MAP3K122.31634169
13STK162.27849766
14MYLK2.17373821
15FRK2.15870157
16NME12.10234962
17MAP3K22.09666359
18AKT32.06634768
19MAPK152.05186058
20NTRK22.01606004
21MAP3K91.95129819
22PAK31.86805543
23ARAF1.84596498
24GRK71.80216685
25PASK1.66415839
26MARK11.66049946
27PRKD31.61856116
28TAOK11.60471871
29TESK11.58444471
30DYRK21.53790393
31MAP2K41.49197033
32ADRBK21.44877072
33MAP4K21.41894981
34ERBB31.41740093
35TESK21.38994512
36WNK31.38783660
37MAPKAPK31.38203667
38MAP3K11.34990256
39KSR21.34063312
40GRK11.32774470
41MINK11.29576682
42NTRK11.22478690
43TRIM281.15689734
44CAMK2A1.15368746
45BRAF1.13777822
46PRKCH1.11189413
47CAMK2B1.07757426
48CDC42BPA1.07388545
49PRKCG1.03475608
50NLK1.00652799
51SCYL21.00073230
52GRK51.00041860
53PRKCE0.98002631
54MAP3K130.95915963
55CAMK2D0.94753012
56CDK50.94188857
57CAMK2G0.91147990
58EPHA30.88568568
59CAMK10.88363542
60PLK20.87141065
61MAP2K10.86584645
62CSNK1A10.85646960
63MAPK130.83605220
64ADRBK10.78248583
65BCR0.73362943
66CAMK40.72661375
67DAPK10.72368551
68OXSR10.72137802
69RPS6KL10.68410096
70RPS6KC10.68410096
71SGK4940.67983273
72SGK2230.67983273
73RPS6KA20.67068075
74FES0.66747857
75FER0.65423997
76MARK20.65172051
77CSNK1G20.64770113
78CAMK1G0.64389461
79CSNK1A1L0.64065125
80CAMKK20.63883545
81CSNK1G30.63369617
82PRKACB0.62084862
83SIK30.61340214
84PAK60.60413229
85WNK40.59804902
86LIMK10.58779508
87SGK20.57741827
88PRKACA0.57039931
89GSK3A0.56738497
90CDK30.55535197
91BMPR20.55123270
92EIF2AK30.54951524
93PTK20.54446776
94MAP2K60.53295251
95PRKCZ0.51326135
96MAP3K70.50488032
97BMPR1B0.48745329
98STK110.48130525
99PRKACG0.48065905
100ALK0.47979440
101PIK3CA0.47136044
102IRAK10.46854934
103ZAK0.45595813
104RPS6KA60.45447445
105DAPK20.45169080
106KSR10.45129939
107RET0.45046051
108TSSK60.43792138
109ERBB40.43223081
110DAPK30.42791888
111MAPK90.42609996
112PHKG10.42240531
113PHKG20.42240531
114DYRK30.41929582
115PRKCA0.41768246
116PKN10.41568825
117BCKDK0.41188939
118PRKCQ0.40884216
119PRKCI0.39755724
120SGK10.39594540
121WNK10.39508454
122CAMKK10.38774284
123RPS6KA30.38659166
124PRKCB0.38190683
125CSNK1D0.37729169
126CSNK1E0.37597149
127RPS6KA50.37540110
128RIPK40.36846366
129ACVR1B0.36492136
130PRKG10.36491730
131PTK60.35813007
132CSNK1G10.35592794
133CHUK0.34931670
134LMTK20.34881534
135EPHA40.34310335
136STK38L0.31443549
137FGFR20.31388116
138FLT30.28714112
139ABL10.24962670
140EPHB10.24789056

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.97599393
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64294419
3Synaptic vesicle cycle_Homo sapiens_hsa047212.96427757
4Collecting duct acid secretion_Homo sapiens_hsa049662.94591131
5Type I diabetes mellitus_Homo sapiens_hsa049402.76500242
6Insulin secretion_Homo sapiens_hsa049112.71296084
7Vibrio cholerae infection_Homo sapiens_hsa051102.71198390
8Oxidative phosphorylation_Homo sapiens_hsa001902.65690105
9Protein export_Homo sapiens_hsa030602.24835340
10GABAergic synapse_Homo sapiens_hsa047272.14378588
11Nicotine addiction_Homo sapiens_hsa050332.14004863
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08604166
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97892517
14Circadian entrainment_Homo sapiens_hsa047131.94335751
15Amphetamine addiction_Homo sapiens_hsa050311.91589009
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87823590
17Alzheimers disease_Homo sapiens_hsa050101.82827708
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81105880
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80708981
20Parkinsons disease_Homo sapiens_hsa050121.78832460
21Sulfur metabolism_Homo sapiens_hsa009201.75045584
22Cocaine addiction_Homo sapiens_hsa050301.73485360
23Morphine addiction_Homo sapiens_hsa050321.71850075
24Taste transduction_Homo sapiens_hsa047421.71343714
25Type II diabetes mellitus_Homo sapiens_hsa049301.70905144
26Folate biosynthesis_Homo sapiens_hsa007901.59721564
27Dopaminergic synapse_Homo sapiens_hsa047281.57052586
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56010561
29Long-term depression_Homo sapiens_hsa047301.54671192
30Long-term potentiation_Homo sapiens_hsa047201.50954299
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47218238
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.45973611
33Glutamatergic synapse_Homo sapiens_hsa047241.42920886
34Renin secretion_Homo sapiens_hsa049241.41127975
35Phototransduction_Homo sapiens_hsa047441.35363339
36Olfactory transduction_Homo sapiens_hsa047401.34334084
37Tryptophan metabolism_Homo sapiens_hsa003801.33998027
38Salivary secretion_Homo sapiens_hsa049701.33988652
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32561811
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.29260346
41Cholinergic synapse_Homo sapiens_hsa047251.27728398
42Serotonergic synapse_Homo sapiens_hsa047261.26721100
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24544151
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23673895
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21520968
46Huntingtons disease_Homo sapiens_hsa050161.17771303
47Cardiac muscle contraction_Homo sapiens_hsa042601.13907839
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09159338
49Thyroid hormone synthesis_Homo sapiens_hsa049181.06632207
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06435338
51N-Glycan biosynthesis_Homo sapiens_hsa005101.06372562
52Butanoate metabolism_Homo sapiens_hsa006501.05895860
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.05818291
54Peroxisome_Homo sapiens_hsa041461.02704300
55Selenocompound metabolism_Homo sapiens_hsa004501.01156718
56Pancreatic secretion_Homo sapiens_hsa049721.01039014
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00616074
58Fatty acid degradation_Homo sapiens_hsa000710.98847056
59Rheumatoid arthritis_Homo sapiens_hsa053230.97359598
60Calcium signaling pathway_Homo sapiens_hsa040200.97064230
61Ether lipid metabolism_Homo sapiens_hsa005650.91521412
62cAMP signaling pathway_Homo sapiens_hsa040240.90294533
63Arginine biosynthesis_Homo sapiens_hsa002200.88944054
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88637550
65Phagosome_Homo sapiens_hsa041450.88419258
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87820661
67* Gastric acid secretion_Homo sapiens_hsa049710.87776413
68Gap junction_Homo sapiens_hsa045400.82423587
69Linoleic acid metabolism_Homo sapiens_hsa005910.80552482
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79674816
71Pyruvate metabolism_Homo sapiens_hsa006200.78918058
72Oxytocin signaling pathway_Homo sapiens_hsa049210.77764060
73Estrogen signaling pathway_Homo sapiens_hsa049150.77273938
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75755334
75AMPK signaling pathway_Homo sapiens_hsa041520.74436803
76Prion diseases_Homo sapiens_hsa050200.73805149
77Fatty acid metabolism_Homo sapiens_hsa012120.73542400
78Glucagon signaling pathway_Homo sapiens_hsa049220.68404283
79Lysosome_Homo sapiens_hsa041420.65623158
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62149521
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61929895
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61729862
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.59039595
84GnRH signaling pathway_Homo sapiens_hsa049120.58105453
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57590893
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57428812
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57098963
88Propanoate metabolism_Homo sapiens_hsa006400.52600625
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52055580
90Dorso-ventral axis formation_Homo sapiens_hsa043200.51907813
91Hedgehog signaling pathway_Homo sapiens_hsa043400.51745280
92Alcoholism_Homo sapiens_hsa050340.51191988
93Dilated cardiomyopathy_Homo sapiens_hsa054140.50482319
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48733321
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48072465
96RNA degradation_Homo sapiens_hsa030180.46698547
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46509254
98Ovarian steroidogenesis_Homo sapiens_hsa049130.45801369
99Melanogenesis_Homo sapiens_hsa049160.45620300
100RNA polymerase_Homo sapiens_hsa030200.44266231
101Metabolic pathways_Homo sapiens_hsa011000.43692032
102Steroid biosynthesis_Homo sapiens_hsa001000.43590285
103Mineral absorption_Homo sapiens_hsa049780.42665226
104Fatty acid elongation_Homo sapiens_hsa000620.42491672
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42069978
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41062308
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40752005
108Regulation of autophagy_Homo sapiens_hsa041400.39372308
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.38778044
110Nitrogen metabolism_Homo sapiens_hsa009100.38522866
111Lysine degradation_Homo sapiens_hsa003100.35558750
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34669994
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34327823
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30642701
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30083644
116Sphingolipid metabolism_Homo sapiens_hsa006000.28465014
117Glycerolipid metabolism_Homo sapiens_hsa005610.27819340
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26511494
119Insulin resistance_Homo sapiens_hsa049310.23802302
120Chemical carcinogenesis_Homo sapiens_hsa052040.23294656
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22441119
122Inositol phosphate metabolism_Homo sapiens_hsa005620.22354615
123Insulin signaling pathway_Homo sapiens_hsa049100.22343058
124MAPK signaling pathway_Homo sapiens_hsa040100.22316393
125Histidine metabolism_Homo sapiens_hsa003400.22192709
126ErbB signaling pathway_Homo sapiens_hsa040120.19197630
127Arachidonic acid metabolism_Homo sapiens_hsa005900.18708608
128Renal cell carcinoma_Homo sapiens_hsa052110.16769323
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16462693
130Fat digestion and absorption_Homo sapiens_hsa049750.16179867
131Circadian rhythm_Homo sapiens_hsa047100.15298978
132Phenylalanine metabolism_Homo sapiens_hsa003600.15031325
133beta-Alanine metabolism_Homo sapiens_hsa004100.14978768
134Glioma_Homo sapiens_hsa052140.14231461
135Ras signaling pathway_Homo sapiens_hsa040140.13678344
136Bile secretion_Homo sapiens_hsa049760.12789150
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12024269

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