SSTR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.51878326
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98455494
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.63444699
4positive regulation of synaptic transmission, GABAergic (GO:0032230)5.37883587
5facial nerve structural organization (GO:0021612)5.24080534
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.23918403
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19858764
8synaptic vesicle exocytosis (GO:0016079)5.18919781
9vocalization behavior (GO:0071625)5.18317238
10glutamate secretion (GO:0014047)5.17854656
11positive regulation of synapse maturation (GO:0090129)5.16476915
12synaptic vesicle maturation (GO:0016188)5.00357884
13protein localization to synapse (GO:0035418)4.94742237
14regulation of glutamate receptor signaling pathway (GO:1900449)4.93837586
15regulation of synaptic vesicle exocytosis (GO:2000300)4.90852642
16neuron cell-cell adhesion (GO:0007158)4.86027558
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.86017575
18tachykinin receptor signaling pathway (GO:0007217)4.78092514
19locomotory exploration behavior (GO:0035641)4.64705179
20cranial nerve structural organization (GO:0021604)4.56195886
21long-term memory (GO:0007616)4.54540717
22regulation of synaptic vesicle transport (GO:1902803)4.49321607
23regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.46333769
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40521495
25negative regulation of dendrite development (GO:2000171)4.21903932
26neurotransmitter-gated ion channel clustering (GO:0072578)4.20777119
27regulation of neuronal synaptic plasticity (GO:0048168)4.18694848
28regulation of synapse structural plasticity (GO:0051823)4.15539880
29regulation of synapse maturation (GO:0090128)4.13387719
30neuron recognition (GO:0008038)4.07099050
31neurotransmitter secretion (GO:0007269)4.03709838
32central nervous system projection neuron axonogenesis (GO:0021952)3.99649147
33postsynaptic membrane organization (GO:0001941)3.94376756
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.93112806
35positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.86880352
36neuronal action potential propagation (GO:0019227)3.85621517
37indole-containing compound catabolic process (GO:0042436)3.84972152
38indolalkylamine catabolic process (GO:0046218)3.84972152
39tryptophan catabolic process (GO:0006569)3.84972152
40axonal fasciculation (GO:0007413)3.80877954
41positive regulation of neurotransmitter secretion (GO:0001956)3.80044459
42synaptic transmission, glutamatergic (GO:0035249)3.77380685
43synaptic transmission, cholinergic (GO:0007271)3.72806912
44activation of protein kinase A activity (GO:0034199)3.71895315
45indolalkylamine metabolic process (GO:0006586)3.70822171
46regulation of synaptic transmission, glutamatergic (GO:0051966)3.70019083
47exploration behavior (GO:0035640)3.68687071
48synaptic vesicle endocytosis (GO:0048488)3.67068817
49layer formation in cerebral cortex (GO:0021819)3.65212343
50behavioral defense response (GO:0002209)3.64656890
51behavioral fear response (GO:0001662)3.64656890
52regulation of postsynaptic membrane potential (GO:0060078)3.63646498
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62584065
54regulation of synaptic transmission, GABAergic (GO:0032228)3.59415174
55regulation of neurotransmitter secretion (GO:0046928)3.57933620
56kynurenine metabolic process (GO:0070189)3.57855361
57fucose catabolic process (GO:0019317)3.56481847
58L-fucose metabolic process (GO:0042354)3.56481847
59L-fucose catabolic process (GO:0042355)3.56481847
60dendritic spine morphogenesis (GO:0060997)3.56339935
61neuron-neuron synaptic transmission (GO:0007270)3.55591986
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.53046377
63presynaptic membrane assembly (GO:0097105)3.51421981
64proline transport (GO:0015824)3.51108487
65glutamate receptor signaling pathway (GO:0007215)3.50142477
66positive regulation of membrane potential (GO:0045838)3.47214835
67gamma-aminobutyric acid transport (GO:0015812)3.47095948
68presynaptic membrane organization (GO:0097090)3.46118946
69long-term synaptic potentiation (GO:0060291)3.44306354
70cell migration in hindbrain (GO:0021535)3.39128519
71learning (GO:0007612)3.38279601
72transmission of nerve impulse (GO:0019226)3.36032991
73regulation of synaptic plasticity (GO:0048167)3.35860782
74fear response (GO:0042596)3.35018273
75positive regulation of digestive system process (GO:0060456)3.34810582
76positive regulation of synaptic transmission (GO:0050806)3.32916618
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.32913738
78neuromuscular synaptic transmission (GO:0007274)3.30292295
79cerebellar granule cell differentiation (GO:0021707)3.28558721
80neuronal action potential (GO:0019228)3.26121053
81negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25775556
82regulation of glutamate secretion (GO:0014048)3.25294657
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24176033
84positive regulation of action potential (GO:0045760)3.23349473
85regulation of glucocorticoid secretion (GO:2000849)3.22675988
86serotonin metabolic process (GO:0042428)3.19531589
87neurotransmitter transport (GO:0006836)3.18909961
88positive regulation of neurotransmitter transport (GO:0051590)3.17887404
89platelet dense granule organization (GO:0060155)3.15730663
90behavioral response to ethanol (GO:0048149)3.15283196
91cerebral cortex radially oriented cell migration (GO:0021799)3.13992763
92membrane depolarization during action potential (GO:0086010)3.13090821
93tryptophan metabolic process (GO:0006568)3.12745888
94reflex (GO:0060004)3.12061234
95regulation of vesicle fusion (GO:0031338)3.11529772
96regulation of neurotransmitter transport (GO:0051588)3.11162739
97indole-containing compound metabolic process (GO:0042430)3.10605904
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10230397
99primary amino compound metabolic process (GO:1901160)3.09633090
100pyrimidine nucleobase catabolic process (GO:0006208)3.09061982
101detection of light stimulus involved in visual perception (GO:0050908)3.06835277
102detection of light stimulus involved in sensory perception (GO:0050962)3.06835277
103glycine transport (GO:0015816)3.06055439
104cellular ketone body metabolic process (GO:0046950)3.05828101
105positive regulation of synapse assembly (GO:0051965)3.05575916
106detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05002129
107positive regulation of muscle cell apoptotic process (GO:0010661)3.04604204
108regulation of synaptic transmission (GO:0050804)3.04443320
109regulation of neurotransmitter uptake (GO:0051580)3.03528173
110mechanosensory behavior (GO:0007638)3.02898399
111* cerebellum development (GO:0021549)3.01950943
112heparin metabolic process (GO:0030202)3.00174731
113heparin biosynthetic process (GO:0030210)3.00174731
114negative regulation of microtubule polymerization (GO:0031115)2.99979667
115negative regulation of dendrite morphogenesis (GO:0050774)2.99454163
116sympathetic nervous system development (GO:0048485)2.98948041
117associative learning (GO:0008306)2.97551208
118regulation of protein kinase A signaling (GO:0010738)2.95771809
119anatomical structure arrangement (GO:0048532)2.93620977
120regulation of neurotransmitter levels (GO:0001505)2.92471436
121G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92346718
122positive regulation of growth hormone secretion (GO:0060124)2.90849611
123response to pheromone (GO:0019236)2.90576917
124protein localization to cilium (GO:0061512)2.88802178
125positive regulation of dendritic spine morphogenesis (GO:0061003)2.88785526
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88277124
127synaptic vesicle transport (GO:0048489)2.86720450
128establishment of synaptic vesicle localization (GO:0097480)2.86720450
129dendrite morphogenesis (GO:0048813)2.86337509
130central nervous system neuron axonogenesis (GO:0021955)2.86306237
1313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.83794398
132purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.83794398
133membrane depolarization (GO:0051899)2.83646849
134DNA deamination (GO:0045006)2.82754600
135gamma-aminobutyric acid signaling pathway (GO:0007214)2.82510556
136startle response (GO:0001964)2.81887544
137positive regulation of amino acid transport (GO:0051957)2.81876118
138negative regulation of interleukin-17 production (GO:0032700)2.81179919
139regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.80319543
140regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.80319543
141auditory behavior (GO:0031223)2.79623100
142regulation of collateral sprouting (GO:0048670)2.79613583
143regulation of dendritic spine morphogenesis (GO:0061001)2.79401761
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78361914
145nucleobase catabolic process (GO:0046113)2.75280328
146adaptation of signaling pathway (GO:0023058)2.72492873
147ketone body metabolic process (GO:1902224)2.70416458
148spinal cord motor neuron differentiation (GO:0021522)2.69467562
149negative regulation of mast cell activation (GO:0033004)2.69442636
150cellular biogenic amine catabolic process (GO:0042402)2.68397916
151amine catabolic process (GO:0009310)2.68397916
152cellular response to ATP (GO:0071318)2.68079314
153sulfation (GO:0051923)2.65919928
154regulation of action potential (GO:0098900)2.63096090
155neural tube formation (GO:0001841)2.60742034
156protein polyglutamylation (GO:0018095)2.57774124
157retinal cone cell development (GO:0046549)2.56997663
158adult walking behavior (GO:0007628)2.55302586
159action potential (GO:0001508)2.50945787
160glycosphingolipid biosynthetic process (GO:0006688)2.50652563
161epithelial cilium movement (GO:0003351)2.50188876
162response to amphetamine (GO:0001975)2.49837704
163alanine transport (GO:0032328)2.49400159
164axoneme assembly (GO:0035082)2.48123102
165regulation of respiratory system process (GO:0044065)2.47667347
166negative regulation of translation, ncRNA-mediated (GO:0040033)2.46903784
167regulation of translation, ncRNA-mediated (GO:0045974)2.46903784
168negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.46903784
169nonmotile primary cilium assembly (GO:0035058)2.46862279
170cAMP catabolic process (GO:0006198)2.46671413
171cellular response to sterol (GO:0036315)2.45815737
172respiratory chain complex IV assembly (GO:0008535)2.45205404
173regulation of cilium movement (GO:0003352)2.40079486
174potassium ion transmembrane transport (GO:0071805)2.39731680
175cellular potassium ion transport (GO:0071804)2.39731680
176regulation of synaptic transmission, dopaminergic (GO:0032225)2.39035354
177regulation of respiratory gaseous exchange (GO:0043576)2.38417863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.76812866
2GBX2_23144817_ChIP-Seq_PC3_Human3.40515174
3REST_21632747_ChIP-Seq_MESCs_Mouse3.18469627
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17754495
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07398808
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06054051
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.93429657
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.73962561
9REST_18959480_ChIP-ChIP_MESCs_Mouse2.73678982
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.70836082
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68027002
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.67731313
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65078503
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62711310
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56255607
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53471763
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51893573
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51893573
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.50844621
20VDR_22108803_ChIP-Seq_LS180_Human2.49935308
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.48920248
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.46664319
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46363257
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44262173
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33682813
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33584668
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.33291709
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29901871
29DROSHA_22980978_ChIP-Seq_HELA_Human2.27660867
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25948685
31IGF1R_20145208_ChIP-Seq_DFB_Human2.25342369
32TAF15_26573619_Chip-Seq_HEK293_Human2.13861499
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.01465294
34* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97497312
35AR_21572438_ChIP-Seq_LNCaP_Human1.80491624
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.78585464
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78325336
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.77969525
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77267165
40EWS_26573619_Chip-Seq_HEK293_Human1.75670563
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75406713
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65157820
43ER_23166858_ChIP-Seq_MCF-7_Human1.60631390
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58811063
45P300_19829295_ChIP-Seq_ESCs_Human1.55968491
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55409040
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50331318
48BCAT_22108803_ChIP-Seq_LS180_Human1.49398431
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47759585
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47528633
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.47312365
52SMAD4_21799915_ChIP-Seq_A2780_Human1.47039515
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46855311
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46497024
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45348695
56FUS_26573619_Chip-Seq_HEK293_Human1.44678906
57RNF2_27304074_Chip-Seq_NSC_Mouse1.43586888
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.39684149
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39159921
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36129283
61* RING1B_27294783_Chip-Seq_ESCs_Mouse1.36089606
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32007834
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31356811
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31000927
65CBP_20019798_ChIP-Seq_JUKART_Human1.31000927
66AR_25329375_ChIP-Seq_VCAP_Human1.30413547
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29775016
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.29327999
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28548283
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28113478
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27401442
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.24236450
73TP53_22573176_ChIP-Seq_HFKS_Human1.23718003
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23485768
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.23074517
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21323882
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20980589
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20875498
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.19769064
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19760278
81* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18277942
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17825937
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.17823977
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.17351486
85FLI1_21867929_ChIP-Seq_TH2_Mouse1.16635914
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15826504
87TCF4_22108803_ChIP-Seq_LS180_Human1.15096628
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.15041557
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14989950
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14357807
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13297621
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12394570
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11834306
94P53_22387025_ChIP-Seq_ESCs_Mouse1.11632004
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11443692
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11289580
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.10868276
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09970659
99NANOG_19829295_ChIP-Seq_ESCs_Human1.09959293
100SOX2_19829295_ChIP-Seq_ESCs_Human1.09959293
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09422820
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07705914
103IRF1_19129219_ChIP-ChIP_H3396_Human1.06819359
104OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06210104
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05847067
106POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03393578
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03284985
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.02782409
109STAT3_18555785_Chip-Seq_ESCs_Mouse1.01987677
110AR_19668381_ChIP-Seq_PC3_Human1.00622647
111JUN_21703547_ChIP-Seq_K562_Human1.00019505
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99638336
113* RUNX2_22187159_ChIP-Seq_PCA_Human0.98440484
114TCF4_23295773_ChIP-Seq_U87_Human0.96073355
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94775393
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.94236866
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93180142
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.92586174
119STAT3_23295773_ChIP-Seq_U87_Human0.92560235
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92557504
121ZNF274_21170338_ChIP-Seq_K562_Hela0.90053095
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89928328
123WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89758306
124ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89430069
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.88182146
126* RING1B_27294783_Chip-Seq_NPCs_Mouse0.87545624
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87001817
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86852066
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86852066
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86239864
131WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85539788
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85329251
133CTCF_27219007_Chip-Seq_Bcells_Human0.84927715
134TET1_21490601_ChIP-Seq_MESCs_Mouse0.84550809
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82803815
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82764020
137AHR_22903824_ChIP-Seq_MCF-7_Human0.81266466
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80749022
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79146616
140SOX9_26525672_Chip-Seq_HEART_Mouse0.78980509
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78714441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.63129417
2MP0003880_abnormal_central_pattern4.26367204
3MP0004270_analgesia3.84320084
4* MP0003635_abnormal_synaptic_transmissio3.75709209
5* MP0002063_abnormal_learning/memory/cond3.25711583
6MP0009745_abnormal_behavioral_response3.23141397
7MP0002735_abnormal_chemical_nociception3.14856608
8MP0001968_abnormal_touch/_nociception3.10203136
9MP0005167_abnormal_blood-brain_barrier3.00776541
10* MP0002572_abnormal_emotion/affect_behav2.96081889
11MP0010386_abnormal_urinary_bladder2.94141021
12MP0002064_seizures2.89412777
13MP0002734_abnormal_mechanical_nocicepti2.89137690
14MP0002638_abnormal_pupillary_reflex2.73836180
15MP0006276_abnormal_autonomic_nervous2.67596609
16MP0003183_abnormal_peptide_metabolism2.61470133
17MP0003195_calcinosis2.60431556
18MP0005423_abnormal_somatic_nervous2.46482935
19MP0000569_abnormal_digit_pigmentation2.45249336
20MP0000778_abnormal_nervous_system2.43616468
21MP0002736_abnormal_nociception_after2.41733744
22MP0009046_muscle_twitch2.36979715
23MP0008877_abnormal_DNA_methylation2.36657191
24* MP0002272_abnormal_nervous_system2.26741057
25MP0002822_catalepsy2.19150326
26MP0001970_abnormal_pain_threshold2.16392035
27MP0001486_abnormal_startle_reflex2.15178257
28MP0002733_abnormal_thermal_nociception2.13118164
29MP0001440_abnormal_grooming_behavior2.02511471
30MP0002184_abnormal_innervation2.02446055
31MP0006292_abnormal_olfactory_placode1.96786327
32MP0002067_abnormal_sensory_capabilities1.90641455
33MP0002557_abnormal_social/conspecific_i1.88928033
34MP0004811_abnormal_neuron_physiology1.85861418
35MP0001984_abnormal_olfaction1.85445644
36MP0005253_abnormal_eye_physiology1.81832594
37MP0002653_abnormal_ependyma_morphology1.80334616
38MP0001188_hyperpigmentation1.75426761
39MP0003122_maternal_imprinting1.73236149
40MP0003787_abnormal_imprinting1.71835871
41MP0002909_abnormal_adrenal_gland1.69485266
42MP0003879_abnormal_hair_cell1.66094827
43MP0009780_abnormal_chondrocyte_physiolo1.64821807
44MP0005645_abnormal_hypothalamus_physiol1.61704464
45MP0001502_abnormal_circadian_rhythm1.60672550
46MP0002254_reproductive_system_inflammat1.60513728
47MP0004885_abnormal_endolymph1.55659803
48MP0008569_lethality_at_weaning1.55631324
49MP0002163_abnormal_gland_morphology1.51925548
50* MP0005386_behavior/neurological_phenoty1.50970379
51* MP0004924_abnormal_behavior1.50970379
52MP0001501_abnormal_sleep_pattern1.49885416
53MP0005646_abnormal_pituitary_gland1.47698144
54MP0004858_abnormal_nervous_system1.45589649
55MP0004142_abnormal_muscle_tone1.42254551
56MP0001986_abnormal_taste_sensitivity1.41996121
57MP0003646_muscle_fatigue1.38716476
58* MP0002066_abnormal_motor_capabilities/c1.37064097
59MP0004043_abnormal_pH_regulation1.36698557
60* MP0002882_abnormal_neuron_morphology1.35777535
61MP0000955_abnormal_spinal_cord1.35205883
62MP0002938_white_spotting1.30687559
63MP0000013_abnormal_adipose_tissue1.28122838
64MP0001529_abnormal_vocalization1.25296482
65MP0005394_taste/olfaction_phenotype1.23440254
66MP0005499_abnormal_olfactory_system1.23440254
67MP0003136_yellow_coat_color1.21579337
68MP0002751_abnormal_autonomic_nervous1.19434377
69MP0004133_heterotaxia1.17988379
70MP0000631_abnormal_neuroendocrine_gland1.16996147
71MP0005084_abnormal_gallbladder_morpholo1.13398656
72MP0002152_abnormal_brain_morphology1.13332885
73MP0002102_abnormal_ear_morphology1.12905566
74MP0003633_abnormal_nervous_system1.10568428
75* MP0001905_abnormal_dopamine_level1.10538674
76MP0002876_abnormal_thyroid_physiology1.08567414
77MP0000538_abnormal_urinary_bladder1.03495312
78MP0000427_abnormal_hair_cycle1.00912408
79MP0000372_irregular_coat_pigmentation0.99623034
80MP0002069_abnormal_eating/drinking_beha0.98050158
81MP0003329_amyloid_beta_deposits0.97057883
82MP0005379_endocrine/exocrine_gland_phen0.96747808
83MP0003632_abnormal_nervous_system0.96227583
84MP0004147_increased_porphyrin_level0.95995565
85MP0005174_abnormal_tail_pigmentation0.93905664
86MP0002693_abnormal_pancreas_physiology0.92839022
87MP0003011_delayed_dark_adaptation0.91168048
88MP0008789_abnormal_olfactory_epithelium0.90277105
89MP0001963_abnormal_hearing_physiology0.87119106
90MP0005535_abnormal_body_temperature0.86713052
91MP0004215_abnormal_myocardial_fiber0.86544304
92MP0001664_abnormal_digestion0.85414578
93* MP0005195_abnormal_posterior_eye0.83371859
94MP0003631_nervous_system_phenotype0.83121872
95MP0003890_abnormal_embryonic-extraembry0.82325336
96MP0004742_abnormal_vestibular_system0.81335721
97MP0008874_decreased_physiological_sensi0.80752392
98MP0003119_abnormal_digestive_system0.80643703
99MP0002837_dystrophic_cardiac_calcinosis0.80582114
100MP0008872_abnormal_physiological_respon0.79368599
101MP0003283_abnormal_digestive_organ0.78367270
102MP0003137_abnormal_impulse_conducting0.76041021
103MP0008875_abnormal_xenobiotic_pharmacok0.75988760
104MP0002928_abnormal_bile_duct0.75911078
105MP0000751_myopathy0.75321929
106MP0003861_abnormal_nervous_system0.75139854
107MP0004145_abnormal_muscle_electrophysio0.73805923
108MP0001485_abnormal_pinna_reflex0.72647459
109MP0006072_abnormal_retinal_apoptosis0.69726849
110MP0005448_abnormal_energy_balance0.69337587
111MP0004085_abnormal_heartbeat0.68387910
112MP0001944_abnormal_pancreas_morphology0.67919091
113* MP0002752_abnormal_somatic_nervous0.67592956
114MP0004233_abnormal_muscle_weight0.67035657
115MP0005409_darkened_coat_color0.66849357
116MP0002229_neurodegeneration0.65960332
117MP0002234_abnormal_pharynx_morphology0.65231929
118MP0003938_abnormal_ear_development0.61218185
119MP0000026_abnormal_inner_ear0.60651368
120MP0003123_paternal_imprinting0.58142933
121MP0003956_abnormal_body_size0.57618201
122MP0003634_abnormal_glial_cell0.57544711
123MP0003121_genomic_imprinting0.56954914
124MP0010770_preweaning_lethality0.56057254
125MP0002082_postnatal_lethality0.56057254
126MP0001177_atelectasis0.54035719
127MP0010769_abnormal_survival0.53332960
128MP0005187_abnormal_penis_morphology0.52996352
129MP0001943_abnormal_respiration0.52573791
130MP0010768_mortality/aging0.50466009
131MP0005551_abnormal_eye_electrophysiolog0.50097661

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.16977358
2Myokymia (HP:0002411)5.93679654
3Epileptic encephalopathy (HP:0200134)5.44575548
4Hyperventilation (HP:0002883)5.25762579
5Visual hallucinations (HP:0002367)5.07520830
6Focal seizures (HP:0007359)4.42314748
7Pancreatic cysts (HP:0001737)3.94756998
8Atonic seizures (HP:0010819)3.86471182
9Febrile seizures (HP:0002373)3.76441765
10Poor eye contact (HP:0000817)3.61400649
11Broad-based gait (HP:0002136)3.60124437
12Abnormality of midbrain morphology (HP:0002418)3.54655143
13Molar tooth sign on MRI (HP:0002419)3.54655143
14Pancreatic fibrosis (HP:0100732)3.39064166
15Congenital stationary night blindness (HP:0007642)3.38320826
16Obstructive sleep apnea (HP:0002870)3.36091188
17Nephronophthisis (HP:0000090)3.31488953
18Epileptiform EEG discharges (HP:0011182)3.27136181
19True hermaphroditism (HP:0010459)3.26845059
20Absence seizures (HP:0002121)3.25478550
21Depression (HP:0000716)3.24980683
22EEG with generalized epileptiform discharges (HP:0011198)3.16928963
23Progressive cerebellar ataxia (HP:0002073)3.15604472
24Stereotypic behavior (HP:0000733)3.14220147
25Anxiety (HP:0000739)3.10928463
26Abnormal hair whorl (HP:0010721)3.10092067
27Abnormal social behavior (HP:0012433)3.06256785
28Impaired social interactions (HP:0000735)3.06256785
29Hypsarrhythmia (HP:0002521)3.05759359
30Type II lissencephaly (HP:0007260)3.03561046
31Sleep apnea (HP:0010535)2.98031461
32Ankle clonus (HP:0011448)2.96156389
33Pheochromocytoma (HP:0002666)2.95450674
34Dialeptic seizures (HP:0011146)2.93938578
35Generalized tonic-clonic seizures (HP:0002069)2.91983287
36Abnormality of the renal medulla (HP:0100957)2.90977024
37Failure to thrive in infancy (HP:0001531)2.82102233
38Agitation (HP:0000713)2.79267748
39Amblyopia (HP:0000646)2.78579634
40Supranuclear gaze palsy (HP:0000605)2.77883633
41Abnormality of the renal cortex (HP:0011035)2.76713996
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.75841445
43Genetic anticipation (HP:0003743)2.75723840
44Impaired vibration sensation in the lower limbs (HP:0002166)2.75272410
45Attenuation of retinal blood vessels (HP:0007843)2.74295471
46Truncal ataxia (HP:0002078)2.71880093
47Protruding tongue (HP:0010808)2.71063624
48Neuroendocrine neoplasm (HP:0100634)2.65128030
49Excessive salivation (HP:0003781)2.64672464
50Drooling (HP:0002307)2.64672464
51Abolished electroretinogram (ERG) (HP:0000550)2.64378092
52Neoplasm of the peripheral nervous system (HP:0100007)2.63620379
53Abnormal eating behavior (HP:0100738)2.61960659
54Blue irides (HP:0000635)2.57989056
55Poor suck (HP:0002033)2.55149934
56Intestinal atresia (HP:0011100)2.52359522
57Inability to walk (HP:0002540)2.51142698
58Abnormality of the lower motor neuron (HP:0002366)2.50992870
59Spastic gait (HP:0002064)2.50762303
60Urinary urgency (HP:0000012)2.48140093
61Menstrual irregularities (HP:0000858)2.46689381
62Progressive inability to walk (HP:0002505)2.46057655
63Large for gestational age (HP:0001520)2.43762064
64Urinary bladder sphincter dysfunction (HP:0002839)2.43497481
65Nonprogressive disorder (HP:0003680)2.40553609
66Cystic liver disease (HP:0006706)2.34239867
67Polydipsia (HP:0001959)2.33841686
68Abnormal drinking behavior (HP:0030082)2.33841686
69Growth hormone excess (HP:0000845)2.31876919
70Congenital sensorineural hearing impairment (HP:0008527)2.31808686
71Spinal canal stenosis (HP:0003416)2.28434965
72Delusions (HP:0000746)2.27970754
73Cerebellar dysplasia (HP:0007033)2.27671212
74Gait imbalance (HP:0002141)2.27641593
75Bony spicule pigmentary retinopathy (HP:0007737)2.26420857
76Abnormality of alanine metabolism (HP:0010916)2.26285693
77Hyperalaninemia (HP:0003348)2.26285693
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26285693
79Hypoventilation (HP:0002791)2.26153383
80Scanning speech (HP:0002168)2.25460787
81Action tremor (HP:0002345)2.24792610
82Hyperthyroidism (HP:0000836)2.24628012
83Hypothermia (HP:0002045)2.24484574
84Lissencephaly (HP:0001339)2.24380724
85Abnormal rod and cone electroretinograms (HP:0008323)2.23784300
86Acute lymphatic leukemia (HP:0006721)2.23694373
87Limb dystonia (HP:0002451)2.23652411
88Keratoconus (HP:0000563)2.23513737
89Increased corneal curvature (HP:0100692)2.23513737
90Torticollis (HP:0000473)2.23334280
91Polyphagia (HP:0002591)2.22655363
92Focal dystonia (HP:0004373)2.22372708
93Chronic hepatic failure (HP:0100626)2.21479369
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.19769275
95Psychosis (HP:0000709)2.18308496
96Severe muscular hypotonia (HP:0006829)2.17560056
97Absent speech (HP:0001344)2.16990460
98Tubular atrophy (HP:0000092)2.16819816
99Esotropia (HP:0000565)2.15901149
100Genital tract atresia (HP:0001827)2.15094222
101Postural instability (HP:0002172)2.14779688
102Bradykinesia (HP:0002067)2.13189532
103Optic nerve hypoplasia (HP:0000609)2.11752494
104Amyotrophic lateral sclerosis (HP:0007354)2.11417859
105Pendular nystagmus (HP:0012043)2.11331931
106Oligodactyly (hands) (HP:0001180)2.10614300
107Vaginal atresia (HP:0000148)2.10312213
108Papilledema (HP:0001085)2.09811367
109Sporadic (HP:0003745)2.09290844
110Tachypnea (HP:0002789)2.09137538
111Gaze-evoked nystagmus (HP:0000640)2.07800549
112Decreased circulating renin level (HP:0003351)2.07539081
113Furrowed tongue (HP:0000221)2.04541316
114Ketoacidosis (HP:0001993)2.04403099
115Impaired pain sensation (HP:0007328)2.01587944
116Abnormality of pain sensation (HP:0010832)2.01587944
117Methylmalonic aciduria (HP:0012120)2.01352249
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00908576
119Methylmalonic acidemia (HP:0002912)2.00548427
120Renal cortical cysts (HP:0000803)1.99878056
121Macroglossia (HP:0000158)1.97627746
122Progressive microcephaly (HP:0000253)1.96389243
123Incomplete penetrance (HP:0003829)1.95796689
124Congenital hepatic fibrosis (HP:0002612)1.93068550
125Medial flaring of the eyebrow (HP:0010747)1.92439579
126Neuroblastic tumors (HP:0004376)1.92295882
127Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.92295882
128Neuroblastoma (HP:0003006)1.92295882
129Primitive neuroectodermal tumor (HP:0030065)1.92295882
130Polyuria (HP:0000103)1.92202217
131Craniofacial dystonia (HP:0012179)1.91573317
132Status epilepticus (HP:0002133)1.91213441
133Autism (HP:0000717)1.90352110
134Pointed chin (HP:0000307)1.90265631
135Patellar aplasia (HP:0006443)1.89488362
136Abnormality of calcium-phosphate metabolism (HP:0100530)1.89075069
137Disproportionate short-trunk short stature (HP:0003521)1.88706758
138Muscular hypotonia of the trunk (HP:0008936)1.87699485
139Nephrogenic diabetes insipidus (HP:0009806)1.87596112
140Hemiparesis (HP:0001269)1.87528030
141Fetal akinesia sequence (HP:0001989)1.87074395
142Congenital primary aphakia (HP:0007707)1.86744957
143Gait ataxia (HP:0002066)1.86160518
144Dysmetria (HP:0001310)1.85423905
145Lower limb muscle weakness (HP:0007340)1.85406116
146Megalencephaly (HP:0001355)1.85256481
147Clumsiness (HP:0002312)1.85001961
148Hypoplasia of the pons (HP:0012110)1.84736889
149Mutism (HP:0002300)1.84667386
150Open mouth (HP:0000194)1.83006447
151Testicular neoplasm (HP:0010788)1.81930845
152Impaired smooth pursuit (HP:0007772)1.81286610
153Aplasia/Hypoplasia of the patella (HP:0006498)1.80856769
154Heterochromia iridis (HP:0001100)1.79725090
155Anencephaly (HP:0002323)1.78969986
156Sclerocornea (HP:0000647)1.78928789
157Chorioretinal atrophy (HP:0000533)1.77625106
158Abnormality of the pons (HP:0007361)1.76308823
159Abnormality of the labia minora (HP:0012880)1.76258574
160Decreased central vision (HP:0007663)1.75602143
161Congenital, generalized hypertrichosis (HP:0004540)1.75566483
162Birth length less than 3rd percentile (HP:0003561)1.75145120
163Retinal dysplasia (HP:0007973)1.74515729
164Tubulointerstitial fibrosis (HP:0005576)1.73366475
165Absent/shortened dynein arms (HP:0200106)1.72497174
166Dynein arm defect of respiratory motile cilia (HP:0012255)1.72497174
167Abnormal respiratory motile cilium morphology (HP:0005938)1.70445991
168Abnormal respiratory epithelium morphology (HP:0012253)1.70445991
169Ketosis (HP:0001946)1.68660592
170Pachygyria (HP:0001302)1.67713527
171Male pseudohermaphroditism (HP:0000037)1.67091265
172Widely spaced teeth (HP:0000687)1.67035010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.03996446
2GRK15.19905446
3NTRK34.34757968
4CASK3.55943296
5MARK13.32782547
6MAP3K123.10844376
7CDK193.08012599
8EPHA43.00734112
9DAPK22.98523131
10TLK12.62716107
11RIPK42.60699729
12DAPK12.58623593
13BMPR1B2.51047349
14FLT32.50469106
15MAP3K42.48444187
16ACVR1B2.47438085
17MAP2K72.45899657
18MAP3K92.33942607
19WNK32.24525132
20TNIK2.24447094
21KIT2.18774815
22MAP4K22.14121526
23MINK12.05170029
24ZAK2.04695222
25KSR11.98428246
26INSRR1.85357357
27KSR21.82177305
28PINK11.81416850
29CCNB11.74542870
30UHMK11.63776421
31MAP2K41.58840696
32MAPK131.43226295
33CAMKK11.35527223
34ARAF1.35035528
35WNK41.32662468
36CAMKK21.31011463
37RAF11.30492752
38NTRK21.30482218
39PLK21.26211758
40SIK21.25687080
41GRK51.24289182
42NUAK11.23812666
43CDK51.22586520
44FES1.21593355
45PRPF4B1.20798416
46PAK61.17954428
47CSF1R1.17645165
48MAPK151.14848428
49SCYL21.14733731
50MKNK21.13314652
51NTRK11.13284268
52PNCK1.11142124
53* ADRBK21.09062513
54STK161.05356398
55PKN11.04753479
56TAOK31.02772495
57MAP3K21.01300469
58PRKCE0.95945485
59STK38L0.94271687
60CSNK1G10.89588969
61MAP2K60.86102526
62EPHB20.85201485
63STK390.85180924
64SGK20.81964210
65GRK70.80688031
66SGK2230.79160077
67SGK4940.79160077
68YES10.78951910
69PRKCG0.78277132
70DAPK30.77690836
71SIK30.74651813
72TXK0.74644747
73DYRK20.71132796
74DYRK1A0.71020241
75TRIM280.69795834
76OXSR10.69091959
77FGFR20.68307751
78CSNK1G20.67079131
79RPS6KA20.66457156
80CDK180.65524828
81CAMK40.65347058
82CAMK10.65109076
83ADRBK10.63513813
84TSSK60.62977573
85MARK20.62713739
86MATK0.62455633
87CDK150.61777233
88CDK140.61435479
89STK110.61132102
90CDK80.59029764
91TGFBR10.57121729
92BRAF0.55079736
93CAMK2A0.55056124
94CDK11A0.54464447
95CAMK2B0.53300630
96SGK30.52545943
97CHUK0.51693225
98MUSK0.50638478
99TNK20.50110941
100RET0.48087577
101MAP3K10.47697725
102CSNK1G30.47115439
103GRK60.46212263
104AKT30.45934632
105PRKACA0.45856620
106IRAK10.45476124
107PRKCH0.44382950
108PTK2B0.43748707
109PIK3CA0.43192717
110VRK10.41730866
111HIPK20.41710590
112BCR0.41406989
113MAP3K70.41106966
114CAMK1G0.41062417
115CSNK1A10.40952177
116RPS6KA50.40025824
117FGR0.39905690
118SYK0.38708735
119CSNK1D0.38571896
120NLK0.38076036
121PRKAA10.37669877
122PRKCQ0.37614341
123ERBB20.36989892
124TAOK10.36580221
125PIM20.36508171
126MAP2K10.36323081
127SGK10.35865023
128MAPKAPK50.35738246
129CDK30.35486890
130MAP3K60.34815828
131BMPR20.34739536
132PRKG10.34553137
133ERBB30.33306382
134PDK10.32926171
135FER0.31661523
136PRKAA20.31445150
137CAMK1D0.31378723
138MAP4K10.31350384
139CSNK1A1L0.31061360
140LIMK10.29679679
141IKBKB0.29552403
142PRKCZ0.29028414
143PRKCA0.28680519
144NME10.28405329
145STK240.27821090
146MST40.27191380
147ROCK20.24923561
148PHKG20.23373154
149PHKG10.23373154
150PAK30.21321867

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.78297125
2Nicotine addiction_Homo sapiens_hsa050333.34152207
3Olfactory transduction_Homo sapiens_hsa047403.08186477
4Circadian entrainment_Homo sapiens_hsa047132.80341782
5Long-term potentiation_Homo sapiens_hsa047202.67199865
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66628989
7GABAergic synapse_Homo sapiens_hsa047272.65475660
8Morphine addiction_Homo sapiens_hsa050322.59227612
9Insulin secretion_Homo sapiens_hsa049112.50896046
10Amphetamine addiction_Homo sapiens_hsa050312.46912055
11Glutamatergic synapse_Homo sapiens_hsa047242.43419663
12Butanoate metabolism_Homo sapiens_hsa006502.40579920
13Collecting duct acid secretion_Homo sapiens_hsa049662.36156205
14Dopaminergic synapse_Homo sapiens_hsa047282.27147191
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.16426281
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.14889808
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06753887
18Renin secretion_Homo sapiens_hsa049242.01269849
19Linoleic acid metabolism_Homo sapiens_hsa005911.91421252
20Cholinergic synapse_Homo sapiens_hsa047251.88345875
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87824759
22* Gastric acid secretion_Homo sapiens_hsa049711.85927559
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85469915
24Nitrogen metabolism_Homo sapiens_hsa009101.82154885
25Tryptophan metabolism_Homo sapiens_hsa003801.80202362
26Long-term depression_Homo sapiens_hsa047301.75968262
27Taste transduction_Homo sapiens_hsa047421.73765378
28Vibrio cholerae infection_Homo sapiens_hsa051101.73288058
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72664733
30Salivary secretion_Homo sapiens_hsa049701.68393401
31Type I diabetes mellitus_Homo sapiens_hsa049401.68123152
32Serotonergic synapse_Homo sapiens_hsa047261.65951338
33Cocaine addiction_Homo sapiens_hsa050301.62900018
34Ether lipid metabolism_Homo sapiens_hsa005651.60947454
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60034930
36Calcium signaling pathway_Homo sapiens_hsa040201.56163055
37Oxytocin signaling pathway_Homo sapiens_hsa049211.52459925
38ABC transporters_Homo sapiens_hsa020101.47135208
39Selenocompound metabolism_Homo sapiens_hsa004501.36708040
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36316946
41Axon guidance_Homo sapiens_hsa043601.35387550
42GnRH signaling pathway_Homo sapiens_hsa049121.34989321
43Gap junction_Homo sapiens_hsa045401.29361900
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27977274
45Estrogen signaling pathway_Homo sapiens_hsa049151.16085078
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.13641690
47* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13512726
48* cAMP signaling pathway_Homo sapiens_hsa040241.13147342
49ErbB signaling pathway_Homo sapiens_hsa040121.10591635
50Glioma_Homo sapiens_hsa052141.05837491
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05579884
52Protein export_Homo sapiens_hsa030601.04776559
53Melanogenesis_Homo sapiens_hsa049161.01113343
54Caffeine metabolism_Homo sapiens_hsa002321.00154142
55Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99967324
56Type II diabetes mellitus_Homo sapiens_hsa049300.97951894
57Pancreatic secretion_Homo sapiens_hsa049720.96973604
58Colorectal cancer_Homo sapiens_hsa052100.95905551
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.95851831
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95319124
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94981223
62Fanconi anemia pathway_Homo sapiens_hsa034600.93963793
63Regulation of autophagy_Homo sapiens_hsa041400.93600957
64Homologous recombination_Homo sapiens_hsa034400.92072232
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.91526711
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84789931
67Basal transcription factors_Homo sapiens_hsa030220.82331434
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.82043619
69Ovarian steroidogenesis_Homo sapiens_hsa049130.81833315
70Alcoholism_Homo sapiens_hsa050340.81763788
71Sulfur metabolism_Homo sapiens_hsa009200.81715478
72Peroxisome_Homo sapiens_hsa041460.81386766
73Propanoate metabolism_Homo sapiens_hsa006400.78816844
74African trypanosomiasis_Homo sapiens_hsa051430.77652217
75Chemical carcinogenesis_Homo sapiens_hsa052040.76453705
76Dorso-ventral axis formation_Homo sapiens_hsa043200.76404895
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.74665666
78Endometrial cancer_Homo sapiens_hsa052130.72341947
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72315368
80Asthma_Homo sapiens_hsa053100.72233270
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70991779
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70009837
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69475593
84Glycerolipid metabolism_Homo sapiens_hsa005610.68656244
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68621459
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68534519
87Oocyte meiosis_Homo sapiens_hsa041140.68393510
88Retinol metabolism_Homo sapiens_hsa008300.68095165
89Phototransduction_Homo sapiens_hsa047440.67255792
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67185201
91Circadian rhythm_Homo sapiens_hsa047100.66482942
92Oxidative phosphorylation_Homo sapiens_hsa001900.66335305
93Mineral absorption_Homo sapiens_hsa049780.65545101
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64439582
95RNA polymerase_Homo sapiens_hsa030200.63791303
96MAPK signaling pathway_Homo sapiens_hsa040100.62282125
97Glucagon signaling pathway_Homo sapiens_hsa049220.62053367
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61892825
99Alzheimers disease_Homo sapiens_hsa050100.60862230
100Vitamin digestion and absorption_Homo sapiens_hsa049770.59661540
101Histidine metabolism_Homo sapiens_hsa003400.58987012
102Arachidonic acid metabolism_Homo sapiens_hsa005900.57896686
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55840373
104Cardiac muscle contraction_Homo sapiens_hsa042600.55665383
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55314242
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55036476
107Parkinsons disease_Homo sapiens_hsa050120.54134163
108Thyroid hormone synthesis_Homo sapiens_hsa049180.54021244
109Acute myeloid leukemia_Homo sapiens_hsa052210.53509542
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53086534
111beta-Alanine metabolism_Homo sapiens_hsa004100.51996449
112Thyroid cancer_Homo sapiens_hsa052160.51905786
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.51683055
114Fat digestion and absorption_Homo sapiens_hsa049750.49016430
115VEGF signaling pathway_Homo sapiens_hsa043700.48360786
116Sphingolipid metabolism_Homo sapiens_hsa006000.48057838
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47287744
118Rap1 signaling pathway_Homo sapiens_hsa040150.46813815
119Prion diseases_Homo sapiens_hsa050200.45315248
120Ras signaling pathway_Homo sapiens_hsa040140.45248400
121Insulin signaling pathway_Homo sapiens_hsa049100.44839028
122Non-small cell lung cancer_Homo sapiens_hsa052230.44694396
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.44582758
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42378208
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42135180
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41814681
127Allograft rejection_Homo sapiens_hsa053300.40900378
128RNA degradation_Homo sapiens_hsa030180.39971214
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38997364
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38545247
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.38176293
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35468332
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.35395936
134Huntingtons disease_Homo sapiens_hsa050160.35379461
135Wnt signaling pathway_Homo sapiens_hsa043100.34675572
136Phagosome_Homo sapiens_hsa041450.34444703
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32428830
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32095660
139Choline metabolism in cancer_Homo sapiens_hsa052310.31906168
140Fatty acid biosynthesis_Homo sapiens_hsa000610.31704479
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31224370
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30868955
143Rheumatoid arthritis_Homo sapiens_hsa053230.30423047
144Pertussis_Homo sapiens_hsa051330.29521396
145Purine metabolism_Homo sapiens_hsa002300.28378697
146Melanoma_Homo sapiens_hsa052180.28361809
147Metabolic pathways_Homo sapiens_hsa011000.28041832
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28021760
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27618239
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26638985
1512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25497967

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