SSTR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.78290332
2Golgi transport vesicle coating (GO:0048200)8.78290332
3protein maturation by protein folding (GO:0022417)6.41405773
4endocrine pancreas development (GO:0031018)6.07703458
5peptide hormone processing (GO:0016486)5.72820516
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.58891041
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47418590
8negative regulation of cell killing (GO:0031342)5.47418590
9regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.40116177
10COPII vesicle coating (GO:0048208)5.17625031
11type B pancreatic cell development (GO:0003323)5.16610142
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.03073304
13insulin secretion (GO:0030073)5.01850548
14glandular epithelial cell differentiation (GO:0002067)4.95612375
15regulation of type B pancreatic cell apoptotic process (GO:2000674)4.90012008
16detection of calcium ion (GO:0005513)4.89753627
17glandular epithelial cell development (GO:0002068)4.66036361
18activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.65564892
19positive regulation of insulin secretion (GO:0032024)4.54421068
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.52684223
21positive regulation of nuclease activity (GO:0032075)4.40085847
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36466657
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36355360
24type I interferon signaling pathway (GO:0060337)4.35566949
25cellular response to type I interferon (GO:0071357)4.35566949
26vesicle coating (GO:0006901)4.32126564
27response to type I interferon (GO:0034340)4.32086854
28protein retention in ER lumen (GO:0006621)4.30871128
29exocrine pancreas development (GO:0031017)4.30022524
30regulation of insulin secretion (GO:0050796)4.27718798
31antigen processing and presentation of endogenous antigen (GO:0019883)4.07329400
32sequestering of metal ion (GO:0051238)4.05427040
33regulation of nuclease activity (GO:0032069)3.98555222
34negative regulation of protein oligomerization (GO:0032460)3.98246825
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96307258
36positive regulation of Rap GTPase activity (GO:0032854)3.95183505
37chemosensory behavior (GO:0007635)3.94606049
38ER overload response (GO:0006983)3.91653434
39regulation of peptide hormone secretion (GO:0090276)3.89818201
40regulation of peptide secretion (GO:0002791)3.85129766
41inner ear receptor cell development (GO:0060119)3.84073383
42L-alpha-amino acid transmembrane transport (GO:1902475)3.82156406
43positive regulation of gamma-delta T cell activation (GO:0046645)3.81923631
44regulation of B cell receptor signaling pathway (GO:0050855)3.80633747
45intra-Golgi vesicle-mediated transport (GO:0006891)3.78642909
46regulation of ARF protein signal transduction (GO:0032012)3.78591681
47cerebellar Purkinje cell layer development (GO:0021680)3.77178757
48endoplasmic reticulum unfolded protein response (GO:0030968)3.76688802
49protein targeting to Golgi (GO:0000042)3.71829220
50peptide hormone secretion (GO:0030072)3.70161596
51negative regulation of T cell mediated immunity (GO:0002710)3.70061837
52cellular response to unfolded protein (GO:0034620)3.67924941
53positive regulation of peptide hormone secretion (GO:0090277)3.67369796
54negative regulation of norepinephrine secretion (GO:0010700)3.64134874
55peptide secretion (GO:0002790)3.63973604
56positive regulation of peptide secretion (GO:0002793)3.61983785
57T cell migration (GO:0072678)3.60902740
58columnar/cuboidal epithelial cell development (GO:0002066)3.59837798
59ER-nucleus signaling pathway (GO:0006984)3.55163472
60nitric oxide mediated signal transduction (GO:0007263)3.55150104
61cellular response to topologically incorrect protein (GO:0035967)3.54228907
62membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.45831282
63negative thymic T cell selection (GO:0045060)3.44820321
64regulation of gamma-delta T cell activation (GO:0046643)3.42664555
65response to interleukin-15 (GO:0070672)3.40596627
66signal peptide processing (GO:0006465)3.39903767
67negative regulation of lymphocyte mediated immunity (GO:0002707)3.39881511
68protein localization to Golgi apparatus (GO:0034067)3.39434946
69cellular response to vitamin D (GO:0071305)3.38536050
70regulation of hormone secretion (GO:0046883)3.36497689
71cellular response to interleukin-15 (GO:0071350)3.36374855
72ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.35953456
73negative regulation of catecholamine secretion (GO:0033604)3.35710918
74toxin metabolic process (GO:0009404)3.35453280
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34693363
76negative T cell selection (GO:0043383)3.34314976
77establishment of protein localization to Golgi (GO:0072600)3.32900664
78synaptic vesicle docking involved in exocytosis (GO:0016081)3.32251125
79regulation of Rap GTPase activity (GO:0032317)3.30149765
80energy homeostasis (GO:0097009)3.27028144
81synaptic vesicle maturation (GO:0016188)3.26904793
82B cell receptor signaling pathway (GO:0050853)3.25662392
83regulation of synaptic vesicle exocytosis (GO:2000300)3.25480403
84tolerance induction (GO:0002507)3.24568124
85regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24538191
86cellular response to glucagon stimulus (GO:0071377)3.23312506
87response to hepatocyte growth factor (GO:0035728)3.18424873
88cellular response to hepatocyte growth factor stimulus (GO:0035729)3.18424873
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17997405
90retrograde transport, vesicle recycling within Golgi (GO:0000301)3.17398309
91macroautophagy (GO:0016236)3.15696901
92regulation of calcium ion-dependent exocytosis (GO:0017158)3.15259105
93regulation of peptide transport (GO:0090087)3.14466623
94negative regulation of cAMP-mediated signaling (GO:0043951)3.10962374
95negative regulation of insulin secretion (GO:0046676)3.09019175
96relaxation of cardiac muscle (GO:0055119)3.07893254
97membrane repolarization during action potential (GO:0086011)3.07167111
98response to endoplasmic reticulum stress (GO:0034976)3.06429488
99response to ischemia (GO:0002931)3.05585749
100regulation of norepinephrine secretion (GO:0014061)3.05274857
101interferon-gamma-mediated signaling pathway (GO:0060333)2.99393835
102negative regulation of glycoprotein biosynthetic process (GO:0010561)2.99334750
103glutamate secretion (GO:0014047)2.98931718
104regulation of gamma-delta T cell differentiation (GO:0045586)2.98674113
105epithelial cell fate commitment (GO:0072148)2.98473735
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98246333
107activation of protein kinase A activity (GO:0034199)2.96590358
108Golgi organization (GO:0007030)2.93582953
109positive regulation of nitric-oxide synthase activity (GO:0051000)2.93157667
110phosphorylated carbohydrate dephosphorylation (GO:0046838)2.91856049
111inositol phosphate dephosphorylation (GO:0046855)2.91856049
112positive regulation of exocytosis (GO:0045921)2.91241069
113inositol phosphate catabolic process (GO:0071545)2.89678803
114modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88738075
115positive regulation by organism of defense response of other organism involved in symbiotic interact2.88738075
116modulation by symbiont of host immune response (GO:0052553)2.88738075
117positive regulation by symbiont of host defense response (GO:0052509)2.88738075
118modulation by symbiont of host defense response (GO:0052031)2.88738075
119modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88738075
120response to unfolded protein (GO:0006986)2.88566684
121peptide transport (GO:0015833)2.86654775
122hypothalamus development (GO:0021854)2.86602689
123glycerophospholipid catabolic process (GO:0046475)2.85538551
124negative regulation of leukocyte mediated immunity (GO:0002704)2.83940719
125astrocyte differentiation (GO:0048708)2.83802901
126interferon-gamma production (GO:0032609)2.83753709
127positive regulation of hormone secretion (GO:0046887)2.83616285
128regulation of synaptic vesicle transport (GO:1902803)2.81925611
129cellular zinc ion homeostasis (GO:0006882)2.81631104
130response to hexose (GO:0009746)2.81535665
131negative regulation of gluconeogenesis (GO:0045721)2.81384704
132response to glucose (GO:0009749)2.80766969
133protein N-linked glycosylation via asparagine (GO:0018279)2.80617025
134hormone secretion (GO:0046879)2.80539680
135negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80307969
136regulation of extracellular matrix disassembly (GO:0010715)2.79887387
137peptidyl-asparagine modification (GO:0018196)2.79580333
138regulation of glucocorticoid secretion (GO:2000849)2.78694912
139response to topologically incorrect protein (GO:0035966)2.78233211
140ER to Golgi vesicle-mediated transport (GO:0006888)2.77634186
141negative regulation of hormone biosynthetic process (GO:0032353)2.77243750
142negative regulation of hormone metabolic process (GO:0032351)2.77243750
143macrophage activation involved in immune response (GO:0002281)2.76257435
144regulation of beta-amyloid formation (GO:1902003)2.75341104
145hormone transport (GO:0009914)2.71461351
146thymic T cell selection (GO:0045061)2.68835122
147regulation of protein glycosylation (GO:0060049)2.67830624
148negative regulation of peptide hormone secretion (GO:0090278)2.67657038
149regulation of isotype switching to IgG isotypes (GO:0048302)2.66597996
150response to monosaccharide (GO:0034284)2.66005559
151energy reserve metabolic process (GO:0006112)2.65241799
152regulation of amyloid precursor protein catabolic process (GO:1902991)2.65201490
153negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.65120402
154cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65101139
155negative regulation of bone resorption (GO:0045779)2.64636291
156immunoglobulin mediated immune response (GO:0016064)2.62910251
157detection of bacterium (GO:0016045)2.61611635
158positive regulation of respiratory burst (GO:0060267)2.61336116
159positive regulation of neurotransmitter transport (GO:0051590)2.60548083
160synaptic vesicle exocytosis (GO:0016079)2.59347563
161regulation of regulatory T cell differentiation (GO:0045589)2.57753472
162CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.55157853
163positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.54776393
164positive regulation of neurotransmitter secretion (GO:0001956)2.54023243
165positive regulation of humoral immune response (GO:0002922)2.53925396
166positive T cell selection (GO:0043368)2.53753229
167leukocyte aggregation (GO:0070486)2.53356492
168negative regulation of innate immune response (GO:0045824)2.52882550
169signal complex assembly (GO:0007172)2.52605230
170negative regulation of erythrocyte differentiation (GO:0045647)2.52170252
171T cell selection (GO:0045058)2.51747218
172regulation of T cell mediated cytotoxicity (GO:0001914)2.51286751
173NIK/NF-kappaB signaling (GO:0038061)2.51122930
174regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49431663
175regulation of type I interferon-mediated signaling pathway (GO:0060338)2.48588488
176nucleoside diphosphate catabolic process (GO:0009134)2.47590696
177RNA destabilization (GO:0050779)2.47473647
178negative regulation of phagocytosis (GO:0050765)2.47091500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.74309066
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.91061631
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.32418897
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.92733889
5EZH2_22144423_ChIP-Seq_EOC_Human3.54276058
6GATA1_22025678_ChIP-Seq_K562_Human3.34353899
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.26049502
8REST_21632747_ChIP-Seq_MESCs_Mouse2.71973782
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41261257
10GBX2_23144817_ChIP-Seq_PC3_Human2.38553871
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.36464908
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21073581
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19976886
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.15720218
15IGF1R_20145208_ChIP-Seq_DFB_Human2.15369047
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.15053713
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.10361976
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.08092283
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07369144
20NR3C1_23031785_ChIP-Seq_PC12_Mouse2.02954430
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98727937
22RUNX_20019798_ChIP-Seq_JUKART_Human1.94890994
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93360966
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91443008
25ZNF274_21170338_ChIP-Seq_K562_Hela1.88912822
26MYC_22102868_ChIP-Seq_BL_Human1.88029812
27MYB_26560356_Chip-Seq_TH2_Human1.85200832
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82214759
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81514767
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.81355184
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78656762
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76174130
33DROSHA_22980978_ChIP-Seq_HELA_Human1.75320447
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74339772
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73645778
36MYB_26560356_Chip-Seq_TH1_Human1.71516035
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69482427
38MAF_26560356_Chip-Seq_TH1_Human1.68875756
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.62099897
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59990146
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57847280
42STAT3_23295773_ChIP-Seq_U87_Human1.51651508
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51588089
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.51408964
45SMAD4_21799915_ChIP-Seq_A2780_Human1.51158905
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.49490288
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49256930
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48420454
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48146292
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47840812
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45596290
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45216464
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.42965833
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40134942
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39049236
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.37681359
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37037851
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36478448
59UTX_26944678_Chip-Seq_JUKART_Human1.36063721
60* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34482093
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34349066
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.33424521
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33043936
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32625149
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31955948
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.31018176
67* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29451925
68MAF_26560356_Chip-Seq_TH2_Human1.28293453
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24861245
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24861245
71YAP1_20516196_ChIP-Seq_MESCs_Mouse1.24790802
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23898245
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23690019
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23127732
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22791262
76AR_19668381_ChIP-Seq_PC3_Human1.22790194
77SPI1_23127762_ChIP-Seq_K562_Human1.22157593
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21828957
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20524502
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20521744
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20256948
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19951858
83KDM2B_26808549_Chip-Seq_DND41_Human1.19683373
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.19147268
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19097528
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17954716
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17622105
88TCF7_22412390_ChIP-Seq_EML_Mouse1.16886412
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.16751815
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15957597
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15825915
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15536038
93* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14944787
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13852918
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12869773
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.12523099
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11553498
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10550231
99REST_19997604_ChIP-ChIP_NEURONS_Mouse1.10107635
100* TCF4_23295773_ChIP-Seq_U87_Human1.08554469
101* GATA3_26560356_Chip-Seq_TH2_Human1.08308449
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08023772
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07913371
104SMAD3_21741376_ChIP-Seq_ESCs_Human1.07911431
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07773814
106VDR_22108803_ChIP-Seq_LS180_Human1.07267200
107SMRT_27268052_Chip-Seq_Bcells_Human1.07180172
108STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04218749
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03487633
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03229162
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02513607
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01708272
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01450630
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01331112
115SMAD_19615063_ChIP-ChIP_OVARY_Human1.00886756
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00878285
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00601607
118CIITA_25753668_ChIP-Seq_RAJI_Human1.00215094
119CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99466998
120SPI1_23547873_ChIP-Seq_NB4_Human0.99353681
121BCAT_22108803_ChIP-Seq_LS180_Human0.98112866
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97840014
123GATA1_19941826_ChIP-Seq_K562_Human0.97322875
124VDR_24763502_ChIP-Seq_THP-1_Human0.96373416
125TP53_22573176_ChIP-Seq_HFKS_Human0.94511707
126TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93461179
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.92207056
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.92128885
129SCL_19346495_ChIP-Seq_HPC-7_Human0.91971132
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91740829
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.91344407
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91318510
133P300_19829295_ChIP-Seq_ESCs_Human0.91243793
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90492054
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89493093
136RUNX2_22187159_ChIP-Seq_PCA_Human0.89199017
137FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89165069
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88250381
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87992295
140AR_25329375_ChIP-Seq_VCAP_Human0.87361796
141KDM2B_26808549_Chip-Seq_K562_Human0.86624277
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86402017
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.85783240
144NANOG_18555785_Chip-Seq_ESCs_Mouse0.85660804
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85093807
146GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84996853
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.84439149
148HTT_18923047_ChIP-ChIP_STHdh_Human0.84285902
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83879985
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83102688
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82896131
152RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82025098
153VDR_21846776_ChIP-Seq_THP-1_Human0.81853929
154VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81331984
155* LXR_22292898_ChIP-Seq_THP-1_Human0.80396743
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.79749815
157VDR_24787735_ChIP-Seq_THP-1_Human0.79733963
158RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79552329
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77179412
160ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76169405
161DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75814798
162PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74744029
163EGR1_19374776_ChIP-ChIP_THP-1_Human0.73814937
164TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.73016147
165TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72575357
166BCOR_27268052_Chip-Seq_Bcells_Human0.72378110
167* GATA3_26560356_Chip-Seq_TH1_Human0.71831026
168KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71055138
169* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70880685
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68982625
171P53_22127205_ChIP-Seq_FIBROBLAST_Human0.68729781
172BRD4_27068464_Chip-Seq_AML-cells_Mouse0.68374962
173NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.68152051
174* KDM2B_26808549_Chip-Seq_JURKAT_Human0.67664953
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.67592294
176SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.66281013
177SMAD4_21741376_ChIP-Seq_ESCs_Human0.66102148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ4.71304317
2MP0002909_abnormal_adrenal_gland4.63591780
3MP0002877_abnormal_melanocyte_morpholog4.51683804
4MP0009780_abnormal_chondrocyte_physiolo4.37613165
5MP0002693_abnormal_pancreas_physiology4.03046009
6MP0000013_abnormal_adipose_tissue3.68726624
7MP0004043_abnormal_pH_regulation3.60157718
8MP0001944_abnormal_pancreas_morphology3.50590691
9MP0003195_calcinosis3.33432422
10MP0005379_endocrine/exocrine_gland_phen3.25360255
11MP0010386_abnormal_urinary_bladder3.13117365
12MP0002837_dystrophic_cardiac_calcinosis3.06582577
13MP0000678_abnormal_parathyroid_gland3.00798653
14MP0003183_abnormal_peptide_metabolism3.00785684
15MP0004270_analgesia2.61248942
16MP0008877_abnormal_DNA_methylation2.42122285
17MP0000685_abnormal_immune_system2.30561189
18MP0005387_immune_system_phenotype2.29286552
19MP0001790_abnormal_immune_system2.29286552
20MP0001835_abnormal_antigen_presentation2.19776471
21MP0002078_abnormal_glucose_homeostasis2.19215307
22MP0003123_paternal_imprinting2.16139538
23MP0004859_abnormal_synaptic_plasticity2.14668476
24MP0003763_abnormal_thymus_physiology2.08859070
25MP0005220_abnormal_exocrine_pancreas2.08093487
26MP0005671_abnormal_response_to1.99287781
27MP0003724_increased_susceptibility_to1.95482727
28MP0001800_abnormal_humoral_immune1.94587425
29MP0005646_abnormal_pituitary_gland1.91841272
30MP0008961_abnormal_basal_metabolism1.84804780
31MP0003172_abnormal_lysosome_physiology1.82618402
32MP0000003_abnormal_adipose_tissue1.82504363
33MP0005000_abnormal_immune_tolerance1.82256922
34MP0006072_abnormal_retinal_apoptosis1.81797361
35MP0002234_abnormal_pharynx_morphology1.80015951
36MP0003122_maternal_imprinting1.77907654
37MP0005645_abnormal_hypothalamus_physiol1.69458668
38MP0006082_CNS_inflammation1.66814418
39MP0003303_peritoneal_inflammation1.65587049
40MP0004510_myositis1.65423172
41MP0004264_abnormal_extraembryonic_tissu1.64040034
42MP0003635_abnormal_synaptic_transmissio1.63224535
43MP0002638_abnormal_pupillary_reflex1.62133569
44MP0009046_muscle_twitch1.61629355
45MP0002723_abnormal_immune_serum1.59330718
46MP0001986_abnormal_taste_sensitivity1.58538719
47MP0001765_abnormal_ion_homeostasis1.57137053
48MP0003436_decreased_susceptibility_to1.51141195
49MP0003868_abnormal_feces_composition1.49560698
50MP0002420_abnormal_adaptive_immunity1.48045997
51MP0001819_abnormal_immune_cell1.44908510
52MP0002896_abnormal_bone_mineralization1.44682528
53MP0003953_abnormal_hormone_level1.37329456
54MP0002452_abnormal_antigen_presenting1.34424143
55MP0002734_abnormal_mechanical_nocicepti1.33389471
56MP0005025_abnormal_response_to1.32326696
57MP0009785_altered_susceptibility_to1.32020903
58MP0005535_abnormal_body_temperature1.30609880
59MP0002928_abnormal_bile_duct1.29503473
60MP0003045_fibrosis1.28689650
61MP0000462_abnormal_digestive_system1.27442632
62MP0004145_abnormal_muscle_electrophysio1.27108586
63MP0002277_abnormal_respiratory_mucosa1.26648241
64MP0009333_abnormal_splenocyte_physiolog1.24857677
65MP0003787_abnormal_imprinting1.24707042
66MP0003866_abnormal_defecation1.24597468
67MP0002166_altered_tumor_susceptibility1.23836295
68MP0003300_gastrointestinal_ulcer1.20706550
69MP0002876_abnormal_thyroid_physiology1.19736163
70MP0002733_abnormal_thermal_nociception1.19364288
71MP0002063_abnormal_learning/memory/cond1.19085063
72MP0002398_abnormal_bone_marrow1.18671488
73MP0005058_abnormal_lysosome_morphology1.18259286
74MP0000716_abnormal_immune_system1.16573724
75MP0002139_abnormal_hepatobiliary_system1.15219108
76MP0003879_abnormal_hair_cell1.15010159
77MP0002572_abnormal_emotion/affect_behav1.14732547
78MP0000631_abnormal_neuroendocrine_gland1.13485503
79MP0000703_abnormal_thymus_morphology1.12065642
80MP0002419_abnormal_innate_immunity1.06164180
81MP0003121_genomic_imprinting1.05579148
82MP0000689_abnormal_spleen_morphology1.05104208
83MP0001502_abnormal_circadian_rhythm1.04802258
84MP0001845_abnormal_inflammatory_respons1.04251898
85MP0005451_abnormal_body_composition1.03479923
86MP0005075_abnormal_melanosome_morpholog1.02509251
87MP0002272_abnormal_nervous_system1.01779230
88MP0008004_abnormal_stomach_pH1.01361583
89MP0005310_abnormal_salivary_gland1.00072178
90MP0003119_abnormal_digestive_system0.99385439
91MP0003690_abnormal_glial_cell0.99036848
92MP0001299_abnormal_eye_distance/0.98958819
93MP0001873_stomach_inflammation0.98008926
94MP0002064_seizures0.97304056
95MP0003252_abnormal_bile_duct0.95322027
96MP0001970_abnormal_pain_threshold0.94582525
97MP0005187_abnormal_penis_morphology0.94370758
98MP0002405_respiratory_system_inflammati0.92938438
99MP0000955_abnormal_spinal_cord0.91346748
100MP0004381_abnormal_hair_follicle0.91001275
101MP0009745_abnormal_behavioral_response0.90302705
102MP0005375_adipose_tissue_phenotype0.89634259
103MP0000613_abnormal_salivary_gland0.89359693
104MP0005448_abnormal_energy_balance0.86839185
105MP0001501_abnormal_sleep_pattern0.85999622
106MP0002722_abnormal_immune_system0.85950969
107MP0002163_abnormal_gland_morphology0.85243540
108MP0003959_abnormal_lean_body0.85009124
109MP0001270_distended_abdomen0.84597966
110MP0010155_abnormal_intestine_physiology0.84233832
111MP0010234_abnormal_vibrissa_follicle0.83123397
112MP0002429_abnormal_blood_cell0.82319271
113MP0004858_abnormal_nervous_system0.82285474
114MP0008469_abnormal_protein_level0.80067343
115MP0009643_abnormal_urine_homeostasis0.79645794
116MP0002557_abnormal_social/conspecific_i0.79169083
117MP0002148_abnormal_hypersensitivity_rea0.79031153
118MP0003633_abnormal_nervous_system0.78760419
119MP0005423_abnormal_somatic_nervous0.78601603
120MP0001348_abnormal_lacrimal_gland0.77464790
121MP0003329_amyloid_beta_deposits0.77072395
122MP0000230_abnormal_systemic_arterial0.76863752
123MP0002069_abnormal_eating/drinking_beha0.75602402
124MP0002254_reproductive_system_inflammat0.74625735
125MP0004811_abnormal_neuron_physiology0.74365540
126MP0000639_abnormal_adrenal_gland0.74333203
127MP0005253_abnormal_eye_physiology0.73290799
128MP0002006_tumorigenesis0.73169095
129MP0002229_neurodegeneration0.72512734
130MP0001756_abnormal_urination0.71520830
131MP0005636_abnormal_mineral_homeostasis0.69437939
132MP0000681_abnormal_thyroid_gland0.69046331
133MP0004085_abnormal_heartbeat0.68539546
134MP0003880_abnormal_central_pattern0.68081178
135MP0005365_abnormal_bile_salt0.66864103
136MP0001533_abnormal_skeleton_physiology0.66802006
137MP0008569_lethality_at_weaning0.66379314
138MP0010329_abnormal_lipoprotein_level0.65791624
139MP0001664_abnormal_digestion0.64641047
140MP0005257_abnormal_intraocular_pressure0.64334989
141MP0000538_abnormal_urinary_bladder0.63823943
142MP0004036_abnormal_muscle_relaxation0.62374455
143MP0002168_other_aberrant_phenotype0.60867819
144MP0002067_abnormal_sensory_capabilities0.60479425
145MP0001486_abnormal_startle_reflex0.59447103
146MP0005670_abnormal_white_adipose0.58902212
147MP0003634_abnormal_glial_cell0.58026956
148MP0002138_abnormal_hepatobiliary_system0.57790093
149MP0002066_abnormal_motor_capabilities/c0.56513337
150MP0002184_abnormal_innervation0.55531733
151MP0001666_abnormal_nutrient_absorption0.55392527
152MP0004924_abnormal_behavior0.54964412

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.95506664
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.87653341
3Hypoglycemic seizures (HP:0002173)6.80546840
4Symptomatic seizures (HP:0011145)6.02390619
5Hypoglycemic coma (HP:0001325)5.67744533
6Insulin-resistant diabetes mellitus (HP:0000831)5.26226305
7Pancreatic islet-cell hyperplasia (HP:0004510)5.18424280
8Abnormality of endocrine pancreas physiology (HP:0012093)5.06632014
9Abnormality of the pancreatic islet cells (HP:0006476)5.06632014
10Hyperglycemia (HP:0003074)4.95530372
11Large for gestational age (HP:0001520)4.72647017
12Ketoacidosis (HP:0001993)4.56937779
13Abnormality of calcium-phosphate metabolism (HP:0100530)4.48435700
14Decreased circulating renin level (HP:0003351)4.08977323
15Late onset (HP:0003584)3.96669407
16Stomatitis (HP:0010280)3.96184265
17Mucopolysacchariduria (HP:0008155)3.67534093
18Urinary glycosaminoglycan excretion (HP:0003541)3.67534093
19Dysostosis multiplex (HP:0000943)3.60642278
20Eczematoid dermatitis (HP:0000976)3.58189638
21Abnormal pancreas size (HP:0012094)3.42212129
22Abnormality of mucopolysaccharide metabolism (HP:0011020)3.38862999
23Abnormality of polysaccharide metabolism (HP:0011012)3.38862999
24Abnormality of glycosaminoglycan metabolism (HP:0004371)3.38862999
25Papilledema (HP:0001085)3.35072273
26Visual hallucinations (HP:0002367)3.34505014
27Hypokalemia (HP:0002900)3.30920042
28EEG with generalized epileptiform discharges (HP:0011198)3.10667844
29Agitation (HP:0000713)3.10011212
30Gastrointestinal stroma tumor (HP:0100723)3.07975358
31Epileptiform EEG discharges (HP:0011182)3.06039202
32Hypsarrhythmia (HP:0002521)3.03661064
33Episodic fever (HP:0001954)3.01697479
34Unilateral renal agenesis (HP:0000122)3.00775094
35Abnormality of renin-angiotensin system (HP:0000847)2.92884982
36Retinal atrophy (HP:0001105)2.90991005
37Hyperparathyroidism (HP:0000843)2.90906255
38Recurrent sinusitis (HP:0011108)2.86937117
39Insulin resistance (HP:0000855)2.84419047
40Prominent metopic ridge (HP:0005487)2.84164611
41Abnormality of aromatic amino acid family metabolism (HP:0004338)2.83486597
42Testicular neoplasm (HP:0010788)2.82079360
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.79436291
44Conjugated hyperbilirubinemia (HP:0002908)2.77056457
45Increased circulating renin level (HP:0000848)2.76098253
46Abnormality of potassium homeostasis (HP:0011042)2.72777925
47Abnormality of macrophages (HP:0004311)2.71762937
48Hypomagnesemia (HP:0002917)2.68021987
49Lymphopenia (HP:0001888)2.67962885
50Generalized aminoaciduria (HP:0002909)2.66893280
51Menstrual irregularities (HP:0000858)2.66222678
52Vasculitis (HP:0002633)2.65197230
53Enlarged penis (HP:0000040)2.63148745
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.62313650
55Osteomalacia (HP:0002749)2.56866016
56Increased CSF protein (HP:0002922)2.56040314
57Recurrent fungal infections (HP:0002841)2.49294709
58Abnormality of the metopic suture (HP:0005556)2.47269721
59Meningitis (HP:0001287)2.46190511
60Recurrent bacterial skin infections (HP:0005406)2.45120209
61Ketosis (HP:0001946)2.42239455
62Hyperkalemia (HP:0002153)2.41346310
63Recurrent cutaneous fungal infections (HP:0011370)2.38743499
64Chronic mucocutaneous candidiasis (HP:0002728)2.38743499
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.34230188
66Dysautonomia (HP:0002459)2.33291164
67Recurrent bronchitis (HP:0002837)2.30518984
68Global brain atrophy (HP:0002283)2.29702917
69Abnormality of the intrinsic pathway (HP:0010989)2.28941994
70Hematochezia (HP:0002573)2.27177997
71Recurrent abscess formation (HP:0002722)2.27046961
72Retrobulbar optic neuritis (HP:0100654)2.26381528
73Optic neuritis (HP:0100653)2.26381528
74Hyperphosphatemia (HP:0002905)2.25220840
75Type I diabetes mellitus (HP:0100651)2.22925525
76Increased IgE level (HP:0003212)2.19956167
77Pheochromocytoma (HP:0002666)2.19934020
78Hyperthyroidism (HP:0000836)2.15994961
79Hyperactive renin-angiotensin system (HP:0000841)2.15863493
80Myositis (HP:0100614)2.14270948
81Recurrent gram-negative bacterial infections (HP:0005420)2.11683587
82Macroorchidism (HP:0000053)2.11183948
83Hypercortisolism (HP:0001578)2.11068850
84Inflammation of the large intestine (HP:0002037)2.10110171
85Recurrent skin infections (HP:0001581)2.09285855
86Hypochromic microcytic anemia (HP:0004840)2.08304662
87Mediastinal lymphadenopathy (HP:0100721)2.08082210
88Orchitis (HP:0100796)2.06855644
89Progressive neurologic deterioration (HP:0002344)2.06591926
90Congenital glaucoma (HP:0001087)2.06027867
91Cortical visual impairment (HP:0100704)2.05596750
92Sex reversal (HP:0012245)2.03872777
93Abnormal sex determination (HP:0012244)2.03872777
94Hypothermia (HP:0002045)2.03607503
95Hypotension (HP:0002615)2.03562074
96Gastrointestinal inflammation (HP:0004386)2.03438494
97Chronic diarrhea (HP:0002028)2.02887925
98Neoplasm of the adrenal cortex (HP:0100641)1.99777394
99Elevated erythrocyte sedimentation rate (HP:0003565)1.99390949
100Exocrine pancreatic insufficiency (HP:0001738)1.97079774
101Intention tremor (HP:0002080)1.96119299
102Abnormality of T cell physiology (HP:0011840)1.95737176
103Agammaglobulinemia (HP:0004432)1.95081522
104Abnormality of magnesium homeostasis (HP:0004921)1.92735816
105Progressive cerebellar ataxia (HP:0002073)1.92065813
106Chronic otitis media (HP:0000389)1.90849715
107Panhypogammaglobulinemia (HP:0003139)1.90795906
108Depression (HP:0000716)1.90795399
109Restlessness (HP:0000711)1.90776127
110IgM deficiency (HP:0002850)1.90495861
111Abdominal distention (HP:0003270)1.90479696
112Focal motor seizures (HP:0011153)1.90104708
113Recurrent viral infections (HP:0004429)1.89521392
114Acne (HP:0001061)1.87142856
115Thoracolumbar scoliosis (HP:0002944)1.86433784
116Type II lissencephaly (HP:0007260)1.86306391
117Gastrointestinal infarctions (HP:0005244)1.86238068
118Failure to thrive in infancy (HP:0001531)1.83522951
119Acute hepatic failure (HP:0006554)1.82612426
120Neuroendocrine neoplasm (HP:0100634)1.82244456
121Abnormality of T cells (HP:0002843)1.81298815
122Papilloma (HP:0012740)1.80539369
123Verrucae (HP:0200043)1.80539369
124Hypophosphatemia (HP:0002148)1.80419564
125Diplopia (HP:0000651)1.80083058
126Abnormality of binocular vision (HP:0011514)1.80083058
127Abnormality of liposaccharide metabolism (HP:0010968)1.79971758
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.79971758
129Abnormality of glycolipid metabolism (HP:0010969)1.79971758
130Chronic bronchitis (HP:0004469)1.78013589
131Supranuclear gaze palsy (HP:0000605)1.77910876
132Pulmonary infiltrates (HP:0002113)1.76724116
133Anxiety (HP:0000739)1.75122899
134Cerebral inclusion bodies (HP:0100314)1.74776733
135Limb hypertonia (HP:0002509)1.74508199
136Impaired smooth pursuit (HP:0007772)1.73685019
137Premature loss of primary teeth (HP:0006323)1.73163411
138Resting tremor (HP:0002322)1.72215776
139Atonic seizures (HP:0010819)1.70332147
140Adrenal overactivity (HP:0002717)1.69391084
141Gout (HP:0001997)1.69047147
142Severe short stature (HP:0003510)1.68306319
143Hyperphosphaturia (HP:0003109)1.67731822
144Muscular hypotonia of the trunk (HP:0008936)1.67721693
145Absence seizures (HP:0002121)1.66475901
146Skin nodule (HP:0200036)1.66415858
147Protuberant abdomen (HP:0001538)1.64409476
148Neurofibrillary tangles (HP:0002185)1.63878229
149Villous atrophy (HP:0011473)1.63304076
150Abnormality of small intestinal villus morphology (HP:0011472)1.63304076
151Intestinal atresia (HP:0011100)1.62973238
152Bundle branch block (HP:0011710)1.61687438
153Generalized hyperpigmentation (HP:0007440)1.59914430
154Glucose intolerance (HP:0000833)1.56030483
155Epileptic encephalopathy (HP:0200134)1.55906267
156Generalized tonic-clonic seizures (HP:0002069)1.55864115
157Hypokalemic alkalosis (HP:0001949)1.54289458
158Postural tremor (HP:0002174)1.54159662
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.53812544
160Hypoplasia of the fovea (HP:0007750)1.53812544
161Abnormal biliary tract morphology (HP:0012440)1.53311390

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.86613013
2MAPK154.84297563
3PASK4.67611626
4TAOK34.32893266
5PRKD33.67991920
6MAP4K13.22521986
7NTRK32.92720517
8MAP3K22.92412340
9FGFR32.84426270
10HIPK22.76649027
11PRPF4B2.73463092
12FGFR42.53298381
13FGFR22.49885218
14FRK2.46506676
15UHMK12.19215365
16SCYL22.04306078
17TYK22.02897794
18CAMKK22.01412530
19TNK21.99761651
20MAP3K11.95217321
21NTRK11.93115158
22IKBKE1.92788403
23WNK31.75071024
24WNK41.60785101
25IRAK41.59944622
26PRKCH1.47503885
27SIK21.45695561
28NLK1.45032541
29PDGFRA1.42229567
30CDC42BPA1.39419547
31FES1.37541508
32FLT31.36256344
33ERN11.32784119
34TAOK11.26290207
35TXK1.23765729
36MAP3K91.15316800
37SYK1.10788606
38CAMKK11.10702307
39BTK1.10219809
40KSR21.10175492
41EPHB11.10161328
42PTK21.08993824
43PRKD21.08721871
44MAP3K41.06416860
45JAK31.05993152
46PAK31.00917077
47SIK30.98035862
48MAP2K60.96627484
49MAP3K140.96319304
50IRAK10.96273416
51PTK60.95136237
52CSK0.93972717
53IRAK30.93381136
54IKBKB0.90835071
55MAPK110.90580991
56HCK0.89919918
57CDK190.87961765
58PRKCQ0.87655578
59TRIB30.87614344
60GRK50.85616083
61AKT30.85380838
62BRSK20.85106303
63RET0.84531615
64DAPK20.83183306
65WNK10.82306756
66EPHA40.81104435
67CDK50.80473528
68BLK0.78844219
69PIK3CG0.77998196
70ARAF0.76078370
71GRK60.75592391
72TBK10.72884773
73PAK60.72380510
74LYN0.70426667
75LCK0.70315615
76DYRK1B0.69711587
77CAMK2D0.68770556
78YES10.67903623
79CHUK0.67158114
80MARK20.67011522
81KIT0.66335632
82FER0.65894372
83CAMK2B0.64779483
84PTK2B0.63820305
85PRKCE0.63766163
86PNCK0.63120242
87MAP3K70.63055530
88RIPK10.62569554
89RIPK40.61303104
90STK240.58329942
91BRAF0.57487645
92JAK20.56772655
93BMPR20.56417650
94PRKCG0.56086858
95EPHA30.55476021
96PRKAA10.55012545
97MINK10.54842746
98EIF2AK30.54386579
99MAP2K70.54110875
100MET0.54070342
101BRD40.51961955
102SGK2230.50732229
103SGK4940.50732229
104MAPK120.50721720
105ZAP700.50458781
106MAP2K20.49481685
107DAPK10.49105533
108CAMK1G0.48942366
109MAPK70.48730492
110PRKD10.47853705
111PRKCZ0.47836844
112SGK30.47753771
113ALK0.47525003
114IRAK20.47427605
115SGK20.47269514
116ADRBK20.45236344
117PINK10.43788315
118BRSK10.42802740
119MARK10.42650719
120DYRK1A0.42493784
121CAMK2A0.41235423
122PDPK10.40660971
123CSF1R0.40013071
124MARK30.39552244
125PRKACG0.39443402
126PHKG10.39164903
127PHKG20.39164903
128CDK120.39104865
129PDGFRB0.37659654
130CSNK1A10.36684494
131SGK10.36269058
132MAP2K40.35909956
133PRKCI0.35529832
134RPS6KA20.34286449
135PRKACA0.33780272
136MAPK100.31060445
137SIK10.30816856
138JAK10.29967730
139PDK10.29892959
140NEK60.29519844
141RPS6KB10.29503351
142* RPS6KA30.29366807
143STK110.28881792
144MAP2K10.28735042
145ITK0.27146756
146STK380.26521317
147CAMK10.25940032
148MAP3K130.24542279
149MAPK140.23403819
150NTRK20.23303649

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.69651077
2Insulin secretion_Homo sapiens_hsa049113.69625190
3Protein export_Homo sapiens_hsa030603.58275846
4Type II diabetes mellitus_Homo sapiens_hsa049302.78256538
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.57238986
6Type I diabetes mellitus_Homo sapiens_hsa049402.36287082
7Sulfur metabolism_Homo sapiens_hsa009202.33226075
8Primary immunodeficiency_Homo sapiens_hsa053402.17458353
9Amphetamine addiction_Homo sapiens_hsa050311.93603587
10Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91051230
11B cell receptor signaling pathway_Homo sapiens_hsa046621.84704816
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82001079
13Autoimmune thyroid disease_Homo sapiens_hsa053201.80179214
14Allograft rejection_Homo sapiens_hsa053301.80040914
15Vibrio cholerae infection_Homo sapiens_hsa051101.78239335
16Long-term potentiation_Homo sapiens_hsa047201.76707710
17Cocaine addiction_Homo sapiens_hsa050301.76682153
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.69716649
19Taste transduction_Homo sapiens_hsa047421.67146173
20Pancreatic secretion_Homo sapiens_hsa049721.60042463
21Synaptic vesicle cycle_Homo sapiens_hsa047211.59767893
22T cell receptor signaling pathway_Homo sapiens_hsa046601.58595214
23Graft-versus-host disease_Homo sapiens_hsa053321.56395248
24Circadian entrainment_Homo sapiens_hsa047131.52814357
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52711672
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50876126
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48435805
28GABAergic synapse_Homo sapiens_hsa047271.43655774
29Dopaminergic synapse_Homo sapiens_hsa047281.41587092
30Measles_Homo sapiens_hsa051621.39620704
31Osteoclast differentiation_Homo sapiens_hsa043801.36460376
32Cholinergic synapse_Homo sapiens_hsa047251.27843074
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25691853
34Glucagon signaling pathway_Homo sapiens_hsa049221.22389043
35Lysosome_Homo sapiens_hsa041421.21646584
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.18422789
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18089921
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15907719
39Morphine addiction_Homo sapiens_hsa050321.15737483
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15441418
41Thyroid hormone synthesis_Homo sapiens_hsa049181.15345695
42N-Glycan biosynthesis_Homo sapiens_hsa005101.14474670
43Circadian rhythm_Homo sapiens_hsa047101.13592174
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.13447197
45Glutamatergic synapse_Homo sapiens_hsa047241.12303430
46Leishmaniasis_Homo sapiens_hsa051401.10591005
47Serotonergic synapse_Homo sapiens_hsa047261.09852791
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08260610
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07536507
50Renin secretion_Homo sapiens_hsa049241.06041038
51Estrogen signaling pathway_Homo sapiens_hsa049151.04726305
52Collecting duct acid secretion_Homo sapiens_hsa049661.03573498
53Chemokine signaling pathway_Homo sapiens_hsa040621.02798292
54Herpes simplex infection_Homo sapiens_hsa051681.00838480
55Influenza A_Homo sapiens_hsa051640.97740880
56Tuberculosis_Homo sapiens_hsa051520.97694392
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95122674
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94775958
59Hepatitis C_Homo sapiens_hsa051600.94205506
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94169139
61Prion diseases_Homo sapiens_hsa050200.92215542
62Insulin resistance_Homo sapiens_hsa049310.92096568
63Gastric acid secretion_Homo sapiens_hsa049710.91857017
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90369440
65Salivary secretion_Homo sapiens_hsa049700.89998057
66Selenocompound metabolism_Homo sapiens_hsa004500.87381559
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.87169951
68Olfactory transduction_Homo sapiens_hsa047400.85316831
69Other glycan degradation_Homo sapiens_hsa005110.84738880
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84374115
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84062558
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.82850321
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.81617443
74Nicotine addiction_Homo sapiens_hsa050330.80212351
75Folate biosynthesis_Homo sapiens_hsa007900.79494007
76cAMP signaling pathway_Homo sapiens_hsa040240.79100797
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79011305
78Prolactin signaling pathway_Homo sapiens_hsa049170.77924864
79Regulation of autophagy_Homo sapiens_hsa041400.76455477
80Dorso-ventral axis formation_Homo sapiens_hsa043200.74937102
81Long-term depression_Homo sapiens_hsa047300.73524448
82GnRH signaling pathway_Homo sapiens_hsa049120.72882129
83Asthma_Homo sapiens_hsa053100.71856455
84Non-small cell lung cancer_Homo sapiens_hsa052230.70939457
85ABC transporters_Homo sapiens_hsa020100.68994819
86Gap junction_Homo sapiens_hsa045400.68292390
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68201258
88mTOR signaling pathway_Homo sapiens_hsa041500.66528116
89Oxytocin signaling pathway_Homo sapiens_hsa049210.66126775
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65955626
91VEGF signaling pathway_Homo sapiens_hsa043700.65429043
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64320726
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63688292
94Calcium signaling pathway_Homo sapiens_hsa040200.63590927
95Hepatitis B_Homo sapiens_hsa051610.62970132
96Melanogenesis_Homo sapiens_hsa049160.62909276
97Insulin signaling pathway_Homo sapiens_hsa049100.62305493
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62007051
99Acute myeloid leukemia_Homo sapiens_hsa052210.60830967
100Rheumatoid arthritis_Homo sapiens_hsa053230.58320000
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57879095
102Inositol phosphate metabolism_Homo sapiens_hsa005620.55650954
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54124243
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53227340
105Antigen processing and presentation_Homo sapiens_hsa046120.51816715
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50911354
107African trypanosomiasis_Homo sapiens_hsa051430.50907811
108Glioma_Homo sapiens_hsa052140.50896279
109Toxoplasmosis_Homo sapiens_hsa051450.50408104
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47999435
111Butanoate metabolism_Homo sapiens_hsa006500.47334127
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43971055
113Staphylococcus aureus infection_Homo sapiens_hsa051500.42490541
114Sphingolipid metabolism_Homo sapiens_hsa006000.42067228
115Alcoholism_Homo sapiens_hsa050340.41710713
116Protein digestion and absorption_Homo sapiens_hsa049740.40490013
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40419613
118Galactose metabolism_Homo sapiens_hsa000520.38691795
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.38052569
120Dilated cardiomyopathy_Homo sapiens_hsa054140.36898936
121Fat digestion and absorption_Homo sapiens_hsa049750.32846562
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32479433
123AMPK signaling pathway_Homo sapiens_hsa041520.31673089
124Ovarian steroidogenesis_Homo sapiens_hsa049130.30030772
125ErbB signaling pathway_Homo sapiens_hsa040120.29739978
126* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29071763
127Endometrial cancer_Homo sapiens_hsa052130.27364550
128Starch and sucrose metabolism_Homo sapiens_hsa005000.27180775
129Tryptophan metabolism_Homo sapiens_hsa003800.26600183
130Renal cell carcinoma_Homo sapiens_hsa052110.26310398
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26160573
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26074338
133MAPK signaling pathway_Homo sapiens_hsa040100.25559782
134Thyroid cancer_Homo sapiens_hsa052160.23988812
135Bladder cancer_Homo sapiens_hsa052190.23570438
136Prostate cancer_Homo sapiens_hsa052150.22677398
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.20034682
138FoxO signaling pathway_Homo sapiens_hsa040680.20019565

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