SSTR5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cholesterol esterification (GO:0010872)6.74795704
2very-low-density lipoprotein particle assembly (GO:0034379)6.16691864
3plasma lipoprotein particle assembly (GO:0034377)6.01459475
4lung epithelium development (GO:0060428)6.00109446
5peptidyl-glutamic acid carboxylation (GO:0017187)5.80302907
6protein carboxylation (GO:0018214)5.80302907
7phospholipid efflux (GO:0033700)5.54011180
8protein-lipid complex assembly (GO:0065005)5.37243006
9regulation of cholesterol biosynthetic process (GO:0045540)5.36863210
10regulation of glutamate secretion (GO:0014048)5.30835310
11high-density lipoprotein particle remodeling (GO:0034375)5.29203085
12histone H4-K12 acetylation (GO:0043983)5.21397809
13regulation of cholesterol homeostasis (GO:2000188)5.19764669
14negative regulation of sterol transport (GO:0032372)5.18821106
15negative regulation of cholesterol transport (GO:0032375)5.18821106
16negative regulation of amino acid transport (GO:0051956)5.15802022
17plasma lipoprotein particle remodeling (GO:0034369)5.15130908
18protein-lipid complex remodeling (GO:0034368)5.15130908
19macromolecular complex remodeling (GO:0034367)5.15130908
20triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.12664502
21embryonic retina morphogenesis in camera-type eye (GO:0060059)4.91793202
22synaptic vesicle maturation (GO:0016188)4.90356820
23neuromuscular process controlling posture (GO:0050884)4.86486717
24neuromuscular process controlling balance (GO:0050885)4.84209746
25cell migration in hindbrain (GO:0021535)4.80927684
26regulation of plasminogen activation (GO:0010755)4.76955165
27plasma lipoprotein particle clearance (GO:0034381)4.75006518
28regulation of bile acid biosynthetic process (GO:0070857)4.69024068
29negative regulation of fibrinolysis (GO:0051918)4.66863476
30cholesterol efflux (GO:0033344)4.61929082
31low-density lipoprotein particle remodeling (GO:0034374)4.59756203
32plasma lipoprotein particle organization (GO:0071827)4.59167174
33proline biosynthetic process (GO:0006561)4.58519494
34reverse cholesterol transport (GO:0043691)4.51418731
35positive regulation of steroid metabolic process (GO:0045940)4.51286805
36regulation of short-term neuronal synaptic plasticity (GO:0048172)4.40981858
37locomotory exploration behavior (GO:0035641)4.39942943
38exploration behavior (GO:0035640)4.36457708
39protein-lipid complex subunit organization (GO:0071825)4.32763785
40respiratory system process (GO:0003016)4.28947806
41regulation of fibrinolysis (GO:0051917)4.20630311
42positive regulation of hormone metabolic process (GO:0032352)4.16241123
43positive regulation of amino acid transport (GO:0051957)4.04890241
44positive regulation of fatty acid biosynthetic process (GO:0045723)3.89913470
45positive regulation of hormone biosynthetic process (GO:0046886)3.88346704
46bone remodeling (GO:0046849)3.87260413
47negative regulation of lipase activity (GO:0060192)3.86076172
48negative regulation of dendrite morphogenesis (GO:0050774)3.84573271
49establishment or maintenance of monopolar cell polarity (GO:0061339)3.81222069
50establishment of monopolar cell polarity (GO:0061162)3.81222069
51vocalization behavior (GO:0071625)3.79026761
52regulation of translational termination (GO:0006449)3.77227704
53regulation of cholesterol metabolic process (GO:0090181)3.75921237
54establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.63187183
55mitochondrion transport along microtubule (GO:0047497)3.63187183
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60567605
57positive regulation of growth hormone secretion (GO:0060124)3.60322929
58intestinal cholesterol absorption (GO:0030299)3.56853369
59basement membrane organization (GO:0071711)3.56013662
60regulation of lipoprotein particle clearance (GO:0010984)3.53036977
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.52435938
62regulation of synaptic vesicle exocytosis (GO:2000300)3.51640027
63regulation of complement activation (GO:0030449)3.47643219
64neuromuscular process (GO:0050905)3.45428873
65regulation of protein activation cascade (GO:2000257)3.44486210
66regulation of extracellular matrix disassembly (GO:0010715)3.42246971
67regulation of cAMP-dependent protein kinase activity (GO:2000479)3.41828098
68proline transport (GO:0015824)3.39982137
69histone H4-K5 acetylation (GO:0043981)3.38848564
70histone H4-K8 acetylation (GO:0043982)3.38848564
71growth hormone secretion (GO:0030252)3.35820499
72establishment of mitochondrion localization (GO:0051654)3.31849718
73positive regulation of steroid biosynthetic process (GO:0010893)3.31394189
74trivalent inorganic anion homeostasis (GO:0072506)3.30504117
75phosphate ion homeostasis (GO:0055062)3.30504117
76calcium-mediated signaling using intracellular calcium source (GO:0035584)3.30436516
77activation of protein kinase A activity (GO:0034199)3.29226671
78regulation of apoptotic cell clearance (GO:2000425)3.28789172
79fibrinolysis (GO:0042730)3.28262769
80negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.27312779
81regulation of fatty acid biosynthetic process (GO:0042304)3.25944732
82fatty acid homeostasis (GO:0055089)3.23957791
83positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.23904758
84regulation of posttranscriptional gene silencing (GO:0060147)3.23569035
85regulation of gene silencing by miRNA (GO:0060964)3.23569035
86regulation of gene silencing by RNA (GO:0060966)3.23569035
87COPI coating of Golgi vesicle (GO:0048205)3.22244150
88Golgi transport vesicle coating (GO:0048200)3.22244150
89negative regulation of lipid transport (GO:0032369)3.22215473
90dopamine receptor signaling pathway (GO:0007212)3.21078595
91synaptic vesicle exocytosis (GO:0016079)3.20849105
92regulation of neuronal synaptic plasticity (GO:0048168)3.18269927
93regulation of extracellular matrix organization (GO:1903053)3.17410979
94regulation of NFAT protein import into nucleus (GO:0051532)3.15776540
95blood coagulation, intrinsic pathway (GO:0007597)3.15074128
96glutamate metabolic process (GO:0006536)3.13453246
97regulation of amino acid transport (GO:0051955)3.11592012
98cholesterol homeostasis (GO:0042632)3.11094621
99lipoprotein metabolic process (GO:0042157)3.09914647
100positive regulation of triglyceride lipase activity (GO:0061365)3.08435344
101positive regulation of lipoprotein lipase activity (GO:0051006)3.08435344
102gamma-aminobutyric acid transport (GO:0015812)3.07896141
103sterol homeostasis (GO:0055092)3.05859239
104negative regulation of blood coagulation (GO:0030195)3.05192200
105negative regulation of hemostasis (GO:1900047)3.05192200
106negative regulation of telomerase activity (GO:0051974)3.05108633
107planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04198730
108positive regulation of cellular response to insulin stimulus (GO:1900078)3.03523171
109biotin metabolic process (GO:0006768)3.02937835
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02877801
111mitotic sister chromatid segregation (GO:0000070)3.01523790
112negative regulation of amine transport (GO:0051953)3.01319884
113regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.01234075
114regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01079501
115adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.00809396
116regulation of synapse structural plasticity (GO:0051823)3.00425089
117negative regulation of fatty acid transport (GO:2000192)3.00224287
118apoptotic process involved in morphogenesis (GO:0060561)2.99254417
119negative regulation of Ras GTPase activity (GO:0034261)2.98917972
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.96782118
121branching involved in mammary gland duct morphogenesis (GO:0060444)2.96413715
122desmosome organization (GO:0002934)2.96381258
123positive regulation of insulin receptor signaling pathway (GO:0046628)2.96178978
124regulation of synaptic vesicle transport (GO:1902803)2.95906805
125neurotransmitter secretion (GO:0007269)2.94999198
126regulation of glucose import in response to insulin stimulus (GO:2001273)2.94852044
127neurofilament cytoskeleton organization (GO:0060052)2.94831282
128positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.94539103
129regulation of glutamate receptor signaling pathway (GO:1900449)2.94516154
130glucose 6-phosphate metabolic process (GO:0051156)2.94051358
131renal system development (GO:0072001)2.93901749
132erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.93755126
133L-phenylalanine metabolic process (GO:0006558)2.93755126
134cell-cell junction maintenance (GO:0045217)2.93707404
135gap junction assembly (GO:0016264)2.92702887
136negative regulation of fatty acid biosynthetic process (GO:0045717)2.90963185
137dendritic spine morphogenesis (GO:0060997)2.90575218
138neuron cell-cell adhesion (GO:0007158)2.90204023
139renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.87965446
140negative regulation of dendrite development (GO:2000171)2.86984930
141negative regulation of catenin import into nucleus (GO:0035414)2.85656392
142positive regulation of protein homooligomerization (GO:0032464)2.85541692
143regulation of autophagic vacuole assembly (GO:2000785)2.85019328
144hemidesmosome assembly (GO:0031581)2.83413242
145organelle transport along microtubule (GO:0072384)2.82667583
146vesicle transport along microtubule (GO:0047496)2.82340640
147bone morphogenesis (GO:0060349)2.81669529
148negative regulation of coagulation (GO:0050819)2.81465322
149somite rostral/caudal axis specification (GO:0032525)2.81062523
150proline metabolic process (GO:0006560)2.79332979
151neuronal action potential propagation (GO:0019227)2.78619601
152regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.76639322
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76558530
154drinking behavior (GO:0042756)2.76487293
155positive regulation of extracellular matrix organization (GO:1903055)2.76446154
156positive regulation of cellular amine metabolic process (GO:0033240)2.75260063
157regulation of metalloenzyme activity (GO:0048552)2.75105804
158female mating behavior (GO:0060180)2.74686084
159regulation of microtubule-based movement (GO:0060632)2.74404899
160regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.74027729
161negative regulation of protein oligomerization (GO:0032460)2.72421552
162establishment of apical/basal cell polarity (GO:0035089)2.72197411
163heterochromatin organization (GO:0070828)2.71631068
164establishment of protein localization to mitochondrial membrane (GO:0090151)2.71103553
165prepulse inhibition (GO:0060134)2.70619163
166glutamine family amino acid biosynthetic process (GO:0009084)2.70465090
167transcription from mitochondrial promoter (GO:0006390)2.70288866
168triglyceride homeostasis (GO:0070328)2.69938723
169acylglycerol homeostasis (GO:0055090)2.69938723
170exocrine pancreas development (GO:0031017)2.69400581
171sterol transport (GO:0015918)2.68929778
172cholesterol transport (GO:0030301)2.68929778
173regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68870910
174positive regulation of lipid catabolic process (GO:0050996)2.68203657
175response to parathyroid hormone (GO:0071107)2.68038979
176protein polyglutamylation (GO:0018095)2.66553178
177synapse assembly (GO:0007416)2.65987286
178protein localization to synapse (GO:0035418)2.64975069
179mitochondrial DNA metabolic process (GO:0032042)2.63528281
180response to dietary excess (GO:0002021)2.63388725
181detection of temperature stimulus (GO:0016048)2.62526031
182activation of Rac GTPase activity (GO:0032863)2.62090547
183regulation of integrin activation (GO:0033623)2.60090362
184regulation of female receptivity (GO:0045924)2.59057679
185regulation of dendritic spine morphogenesis (GO:0061001)2.58860084
186cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58586053
187transmission of nerve impulse (GO:0019226)2.58527575
188atrial cardiac muscle cell action potential (GO:0086014)2.58464462
189innervation (GO:0060384)2.57446807
190regulation of protein homooligomerization (GO:0032462)2.57347636
191regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.54907990
192regulation of circadian sleep/wake cycle (GO:0042749)2.54907990
193replication fork processing (GO:0031297)2.53965205
194neuron fate specification (GO:0048665)2.53925341
195cerebellar Purkinje cell layer development (GO:0021680)2.53412157
196regulation of vacuole organization (GO:0044088)2.52442020
197positive regulation of membrane potential (GO:0045838)2.50541891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.96794028
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78269176
3SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.64362605
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.54581621
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.54581621
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.54581621
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.40350347
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.17486511
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.01552739
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.95289049
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.93798934
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.82755305
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.78922898
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.67771845
15* ERG_21242973_ChIP-ChIP_JURKAT_Human2.62193583
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.61819636
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.59667524
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54881105
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.45760366
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.43958117
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.33304568
22REST_21632747_ChIP-Seq_MESCs_Mouse2.33170495
23* RCOR3_21632747_ChIP-Seq_MESCs_Mouse2.20753000
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.20678508
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20362239
26POU5F1_16518401_ChIP-PET_MESCs_Mouse2.19012948
27TCF3_18692474_ChIP-Seq_MESCs_Mouse2.18702410
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15000894
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.12510811
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.11456215
31ZFP281_27345836_Chip-Seq_ESCs_Mouse2.08964711
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.01878908
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96589965
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92454812
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.89513757
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89488571
37SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.85445921
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81958328
39MYC_22102868_ChIP-Seq_BL_Human1.81304639
40NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.79872500
41P68_20966046_ChIP-Seq_HELA_Human1.78830107
42KDM2B_26808549_Chip-Seq_K562_Human1.78380422
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.75236453
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71634379
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70148627
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68960176
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68375484
48PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.61816715
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.61510574
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59816313
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55752928
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55693518
53NANOG_18692474_ChIP-Seq_MESCs_Mouse1.55675915
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55573610
55VDR_21846776_ChIP-Seq_THP-1_Human1.54541242
56NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.54173625
57TCF7_22412390_ChIP-Seq_EML_Mouse1.51077792
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50939975
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.50644770
60ATF3_27146783_Chip-Seq_COLON_Human1.47214473
61* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46375605
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46223121
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.45644658
64CTCF_27219007_Chip-Seq_Bcells_Human1.44895257
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44468472
66TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.43209214
67SOX2_18692474_ChIP-Seq_MESCs_Mouse1.43144925
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42491406
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40766494
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40515501
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40383354
72EZH2_22144423_ChIP-Seq_EOC_Human1.39761208
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39446253
74OCT4_18692474_ChIP-Seq_MEFs_Mouse1.38874742
75LXR_22292898_ChIP-Seq_THP-1_Human1.37784284
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.36737996
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36485182
78CLOCK_20551151_ChIP-Seq_293T_Human1.35809241
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35792731
80TP53_22127205_ChIP-Seq_IMR90_Human1.35438734
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35205273
82* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35197032
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35170844
84RARB_24833708_ChIP-Seq_LIVER_Mouse1.34536276
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34458947
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33504948
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33340321
88POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.33190122
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32895841
90SOX2_18692474_ChIP-Seq_MEFs_Mouse1.32640551
91POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.31723700
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31359787
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30727621
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.29847492
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27207730
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27139104
97NANOG_16518401_ChIP-PET_MESCs_Mouse1.25606279
98RACK7_27058665_Chip-Seq_MCF-7_Human1.25227570
99AR_21909140_ChIP-Seq_LNCAP_Human1.24966052
100TET1_21490601_ChIP-Seq_MESCs_Mouse1.24836465
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24266684
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.23061215
103NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22439980
104HNF4A_19822575_ChIP-Seq_HepG2_Human1.22129720
105* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21748181
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.21594513
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.21166518
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19394085
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19074358
110EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18788846
111RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18788846
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18133851
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18131065
114* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16997809
115GATA6_25053715_ChIP-Seq_YYC3_Human1.16435293
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16331351
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16223385
118CREB1_26743006_Chip-Seq_LNCaP_Human1.14521294
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14116280
120* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13677189
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13668692
122ZNF263_19887448_ChIP-Seq_K562_Human1.12686430
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12134550
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11731456
125SA1_27219007_Chip-Seq_ERYTHROID_Human1.11155169
126NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08704297
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08391829
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07585825
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07550990
130* SMC4_20622854_ChIP-Seq_HELA_Human1.07171982
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06289412
132RNF2_27304074_Chip-Seq_ESCs_Mouse1.06117446
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05728346
134BCOR_27268052_Chip-Seq_Bcells_Human1.05351761
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04315514
136KAP1_27257070_Chip-Seq_ESCs_Mouse1.04196276
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03654439
138* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03610532
139ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03566320
140STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02191042
141SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01869352
142STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01142379
143RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98204687
144SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98172291
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.97740951
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.97740690
147TP53_20018659_ChIP-ChIP_R1E_Mouse0.97726847
148OCT4_19829295_ChIP-Seq_ESCs_Human0.97238314
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97117939
150ETS1_21867929_ChIP-Seq_TH2_Mouse0.96782203
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.96720842
152MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96238524
153SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95969820
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95535790
155KDM2B_26808549_Chip-Seq_DND41_Human0.95174343
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95118605
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94945313
158BCL6_27268052_Chip-Seq_Bcells_Human0.94381980
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94291419
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.93652862
161JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91841323
162EGR1_19374776_ChIP-ChIP_THP-1_Human0.90502383
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.90182935
164POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90135767
165BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89745403
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89328474
167WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88035909
168RNF2_27304074_Chip-Seq_NSC_Mouse0.87695509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.62380665
2MP0005360_urolithiasis5.28416051
3MP0003122_maternal_imprinting4.78236892
4MP0005645_abnormal_hypothalamus_physiol4.31168929
5MP0002822_catalepsy4.18003675
6MP0004859_abnormal_synaptic_plasticity4.14727482
7MP0003123_paternal_imprinting3.46895516
8MP0009046_muscle_twitch3.35123060
9MP0005451_abnormal_body_composition3.33908394
10MP0009840_abnormal_foam_cell2.92976667
11MP0005365_abnormal_bile_salt2.83200877
12MP0000537_abnormal_urethra_morphology2.76592012
13MP0003635_abnormal_synaptic_transmissio2.67896200
14MP0002089_abnormal_postnatal_growth/wei2.53467170
15MP0003121_genomic_imprinting2.53199955
16MP0002735_abnormal_chemical_nociception2.47835585
17MP0002909_abnormal_adrenal_gland2.46473904
18MP0002139_abnormal_hepatobiliary_system2.41848825
19MP0004858_abnormal_nervous_system2.41022009
20MP0003283_abnormal_digestive_organ2.36630834
21MP0004270_analgesia2.32679717
22MP0002063_abnormal_learning/memory/cond2.31766456
23MP0001348_abnormal_lacrimal_gland2.27340942
24MP0003787_abnormal_imprinting2.25236701
25MP0005076_abnormal_cell_differentiation2.24617167
26MP0004185_abnormal_adipocyte_glucose2.23972354
27MP0002653_abnormal_ependyma_morphology2.21833176
28MP0003315_abnormal_perineum_morphology2.19848588
29MP0010329_abnormal_lipoprotein_level2.11750497
30MP0008057_abnormal_DNA_replication2.11229057
31MP0002733_abnormal_thermal_nociception2.11086407
32MP0009745_abnormal_behavioral_response2.07821319
33MP0002064_seizures2.05510830
34MP0002572_abnormal_emotion/affect_behav2.05000312
35MP0003880_abnormal_central_pattern1.92311333
36MP0004133_heterotaxia1.90989762
37MP0002166_altered_tumor_susceptibility1.88036049
38MP0001970_abnormal_pain_threshold1.88012114
39MP0006276_abnormal_autonomic_nervous1.86682185
40MP0001440_abnormal_grooming_behavior1.86057349
41MP0002249_abnormal_larynx_morphology1.78236983
42MP0005670_abnormal_white_adipose1.75715954
43MP0002272_abnormal_nervous_system1.74097700
44MP0003705_abnormal_hypodermis_morpholog1.70437343
45MP0000538_abnormal_urinary_bladder1.68647102
46MP0003890_abnormal_embryonic-extraembry1.65581321
47MP0004811_abnormal_neuron_physiology1.65231040
48MP0001968_abnormal_touch/_nociception1.64812817
49MP0004885_abnormal_endolymph1.63217954
50MP0000955_abnormal_spinal_cord1.62215421
51MP0001188_hyperpigmentation1.59574976
52MP0010234_abnormal_vibrissa_follicle1.53213455
53MP0009780_abnormal_chondrocyte_physiolo1.50821559
54MP0005257_abnormal_intraocular_pressure1.49304109
55MP0001666_abnormal_nutrient_absorption1.49303642
56MP0000751_myopathy1.48359411
57MP0003879_abnormal_hair_cell1.46449219
58MP0000631_abnormal_neuroendocrine_gland1.46224086
59MP0010030_abnormal_orbit_morphology1.44789426
60MP0002736_abnormal_nociception_after1.44412797
61MP0002184_abnormal_innervation1.43712397
62MP0001486_abnormal_startle_reflex1.42476702
63MP0004145_abnormal_muscle_electrophysio1.41209359
64MP0002734_abnormal_mechanical_nocicepti1.40669387
65MP0004142_abnormal_muscle_tone1.39278557
66MP0003195_calcinosis1.38469383
67MP0001661_extended_life_span1.37359278
68MP0005666_abnormal_adipose_tissue1.37180159
69MP0008875_abnormal_xenobiotic_pharmacok1.36191594
70MP0004264_abnormal_extraembryonic_tissu1.34839159
71MP0006072_abnormal_retinal_apoptosis1.33460747
72MP0000003_abnormal_adipose_tissue1.32041446
73MP0002006_tumorigenesis1.31896967
74MP0008995_early_reproductive_senescence1.29484516
75MP0005085_abnormal_gallbladder_physiolo1.29288275
76MP0003115_abnormal_respiratory_system1.26523204
77MP0005386_behavior/neurological_phenoty1.26313347
78MP0004924_abnormal_behavior1.26313347
79MP0000678_abnormal_parathyroid_gland1.23642575
80MP0005058_abnormal_lysosome_morphology1.22325043
81MP0005220_abnormal_exocrine_pancreas1.22174447
82MP0000467_abnormal_esophagus_morphology1.22123577
83MP0005167_abnormal_blood-brain_barrier1.17557968
84MP0002234_abnormal_pharynx_morphology1.17217720
85MP0001727_abnormal_embryo_implantation1.15991194
86MP0005375_adipose_tissue_phenotype1.15954968
87MP0003329_amyloid_beta_deposits1.15212694
88MP0003172_abnormal_lysosome_physiology1.13233553
89MP0000778_abnormal_nervous_system1.12058150
90MP0003137_abnormal_impulse_conducting1.12014425
91MP0002066_abnormal_motor_capabilities/c1.11746422
92MP0002118_abnormal_lipid_homeostasis1.11550667
93MP0002882_abnormal_neuron_morphology1.11079910
94MP0004272_abnormal_basement_membrane1.09796022
95MP0002751_abnormal_autonomic_nervous1.09180423
96MP0005409_darkened_coat_color1.08945621
97MP0003942_abnormal_urinary_system1.06864196
98MP0002557_abnormal_social/conspecific_i1.05386659
99MP0004233_abnormal_muscle_weight1.05075713
100MP0002067_abnormal_sensory_capabilities1.04619624
101MP0008877_abnormal_DNA_methylation1.04265255
102MP0005499_abnormal_olfactory_system1.03789217
103MP0005394_taste/olfaction_phenotype1.03789217
104MP0001501_abnormal_sleep_pattern1.02927116
105MP0010386_abnormal_urinary_bladder1.01370290
106MP0006292_abnormal_olfactory_placode1.01257777
107MP0002332_abnormal_exercise_endurance1.01236924
108MP0000609_abnormal_liver_physiology1.00500879
109MP0003453_abnormal_keratinocyte_physiol1.00380819
110MP0005623_abnormal_meninges_morphology0.98926467
111MP0010630_abnormal_cardiac_muscle0.98693342
112MP0008961_abnormal_basal_metabolism0.92900944
113MP0001915_intracranial_hemorrhage0.92857039
114MP0002152_abnormal_brain_morphology0.92697331
115MP0008260_abnormal_autophagy0.92529641
116MP0000733_abnormal_muscle_development0.91775865
117MP0003566_abnormal_cell_adhesion0.90064396
118MP0002108_abnormal_muscle_morphology0.88477073
119MP0000534_abnormal_ureter_morphology0.87403407
120MP0003943_abnormal_hepatobiliary_system0.86802024
121MP0003633_abnormal_nervous_system0.86724276
122MP0005448_abnormal_energy_balance0.86660002
123MP0008872_abnormal_physiological_respon0.86443584
124MP0003075_altered_response_to0.83779764
125MP0002269_muscular_atrophy0.82813022
126MP0002752_abnormal_somatic_nervous0.81907796
127MP0001764_abnormal_homeostasis0.81254410
128MP0000639_abnormal_adrenal_gland0.79535665
129MP0003861_abnormal_nervous_system0.79309566
130MP0000579_abnormal_nail_morphology0.78893577
131MP0003786_premature_aging0.78312014
132MP0002229_neurodegeneration0.76493276
133MP0010352_gastrointestinal_tract_polyps0.75976937
134MP0002009_preneoplasia0.75731358
135MP0005332_abnormal_amino_acid0.75282454
136MP0001502_abnormal_circadian_rhythm0.74627704
137MP0005501_abnormal_skin_physiology0.74238954
138MP0002970_abnormal_white_adipose0.73143413
139MP0003111_abnormal_nucleus_morphology0.72687266
140MP0004957_abnormal_blastocyst_morpholog0.72387541
141MP0000747_muscle_weakness0.70552825
142MP0000762_abnormal_tongue_morphology0.70444944
143MP0003634_abnormal_glial_cell0.70358249
144MP0003191_abnormal_cellular_cholesterol0.70258432
145MP0008789_abnormal_olfactory_epithelium0.70234379
146MP0002084_abnormal_developmental_patter0.69645463
147MP0003119_abnormal_digestive_system0.69581177
148MP0005330_cardiomyopathy0.69230563
149MP0002254_reproductive_system_inflammat0.67664450
150MP0000858_altered_metastatic_potential0.66929370
151MP0005423_abnormal_somatic_nervous0.66393439
152MP0001849_ear_inflammation0.66164188
153MP0004087_abnormal_muscle_fiber0.65782208
154MP0002233_abnormal_nose_morphology0.65722258
155MP0005266_abnormal_metabolism0.65683531
156MP0003984_embryonic_growth_retardation0.63934557
157MP0001730_embryonic_growth_arrest0.63915004
158MP0002086_abnormal_extraembryonic_tissu0.63893000
159MP0001485_abnormal_pinna_reflex0.63879560
160MP0001943_abnormal_respiration0.63427298
161MP0005083_abnormal_biliary_tract0.62318069
162MP0008569_lethality_at_weaning0.62210164
163MP0008874_decreased_physiological_sensi0.60150712
164MP0001529_abnormal_vocalization0.60138778
165MP0002098_abnormal_vibrissa_morphology0.60129626
166MP0004197_abnormal_fetal_growth/weight/0.59639826
167MP0002060_abnormal_skin_morphology0.59596169
168MP0000350_abnormal_cell_proliferation0.58779303
169MP0008770_decreased_survivor_rate0.57835594
170MP0002085_abnormal_embryonic_tissue0.57758346
171MP0004036_abnormal_muscle_relaxation0.56937577
172MP0002971_abnormal_brown_adipose0.56801958
173MP0000598_abnormal_liver_morphology0.56488300
174MP0002088_abnormal_embryonic_growth/wei0.55833835

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.27464721
2Abnormality of the lower motor neuron (HP:0002366)6.73485050
3Myokymia (HP:0002411)6.08549046
4Hemorrhage of the eye (HP:0011885)5.49569424
5Joint hemorrhage (HP:0005261)4.88900495
6Abnormality of the labia minora (HP:0012880)4.52714568
7Hypercortisolism (HP:0001578)4.26855012
8Prolonged partial thromboplastin time (HP:0003645)4.26464922
9Asymmetry of the thorax (HP:0001555)4.24486044
10Flat acetabular roof (HP:0003180)3.96778495
11Xanthomatosis (HP:0000991)3.61815783
12Rib fusion (HP:0000902)3.57967771
13Premature skin wrinkling (HP:0100678)3.55796692
14Abnormality of carpal bone ossification (HP:0006257)3.52471037
15Amyotrophic lateral sclerosis (HP:0007354)3.42991823
16Annular pancreas (HP:0001734)3.28664161
17Tongue fasciculations (HP:0001308)3.26498172
18Hypochromic microcytic anemia (HP:0004840)3.22161534
19Hypercholesterolemia (HP:0003124)3.20644516
20Bifid scrotum (HP:0000048)3.11932027
21Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11759273
22Ventricular fibrillation (HP:0001663)3.09830360
23Ulnar bowing (HP:0003031)3.05695199
24Ankyloglossia (HP:0010296)3.05298375
25Febrile seizures (HP:0002373)3.02914069
26Failure to thrive in infancy (HP:0001531)2.99069031
27Muscle fibrillation (HP:0010546)2.94435779
28Bronchomalacia (HP:0002780)2.94357950
29Hypobetalipoproteinemia (HP:0003563)2.94299925
30Astrocytoma (HP:0009592)2.94157113
31Abnormality of the astrocytes (HP:0100707)2.94157113
32Shawl scrotum (HP:0000049)2.93013175
33Late onset (HP:0003584)2.91893043
34Focal seizures (HP:0007359)2.84377015
35Abnormal ossification of hand bones (HP:0005921)2.81379851
36Facial hemangioma (HP:0000329)2.80510677
37Neonatal death (HP:0003811)2.79378381
38Partial duplication of thumb phalanx (HP:0009944)2.66573877
39Stridor (HP:0010307)2.63423351
40Atonic seizures (HP:0010819)2.60099888
41Protrusio acetabuli (HP:0003179)2.58498499
42Abnormal hand bone ossification (HP:0010660)2.57183712
43Broad face (HP:0000283)2.56894537
44Pterygium (HP:0001059)2.56786512
45Distal lower limb muscle weakness (HP:0009053)2.55589646
46Impaired pain sensation (HP:0007328)2.54117179
47Abnormality of pain sensation (HP:0010832)2.54117179
48Focal motor seizures (HP:0011153)2.51552947
49Dialeptic seizures (HP:0011146)2.49379581
50Absence seizures (HP:0002121)2.49300130
51Action tremor (HP:0002345)2.49181887
52Menorrhagia (HP:0000132)2.48761503
53Diaphragmatic weakness (HP:0009113)2.48053373
54Resting tremor (HP:0002322)2.47444187
55Epileptic encephalopathy (HP:0200134)2.46158873
56Ependymoma (HP:0002888)2.43848438
57Obstructive sleep apnea (HP:0002870)2.43784690
58Depression (HP:0000716)2.43531815
59Amblyopia (HP:0000646)2.42417437
60Ureteral stenosis (HP:0000071)2.40245782
61Abnormality of the distal phalanges of the toes (HP:0010182)2.36461181
62Urethral obstruction (HP:0000796)2.35765137
63Generalized hypotonia (HP:0001290)2.34547429
64Abnormality of the Achilles tendon (HP:0005109)2.33312526
65Visual hallucinations (HP:0002367)2.33023128
66Progressive cerebellar ataxia (HP:0002073)2.32683917
67Spastic gait (HP:0002064)2.30938757
68Hyperacusis (HP:0010780)2.29946058
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.29773498
70Concave nail (HP:0001598)2.28997136
71Abnormality of the aortic arch (HP:0012303)2.27828664
72Hypoalphalipoproteinemia (HP:0003233)2.26356236
73Hypolipoproteinemia (HP:0010981)2.25000220
74Coxa vara (HP:0002812)2.24661976
75Aplasia involving bones of the upper limbs (HP:0009823)2.22243474
76Aplasia of the phalanges of the hand (HP:0009802)2.22243474
77Aplasia involving bones of the extremities (HP:0009825)2.22243474
78Spinal muscular atrophy (HP:0007269)2.20874618
79Abnormality of the corticospinal tract (HP:0002492)2.18149790
80Fragile skin (HP:0001030)2.17033684
81Right ventricular cardiomyopathy (HP:0011663)2.16833022
82Anxiety (HP:0000739)2.15322474
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.15280660
84Broad alveolar ridges (HP:0000187)2.14619315
85Ureteral obstruction (HP:0006000)2.14338594
86Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12909393
87Biconcave vertebral bodies (HP:0004586)2.12726360
88Abnormal EKG (HP:0003115)2.11720638
89Impaired vibration sensation in the lower limbs (HP:0002166)2.11470345
90Partial duplication of the phalanx of hand (HP:0009999)2.10918716
91Pigmentary retinal degeneration (HP:0001146)2.10333436
92Progressive sensorineural hearing impairment (HP:0000408)2.10176084
93Upper limb amyotrophy (HP:0009129)2.09611387
94Distal upper limb amyotrophy (HP:0007149)2.09611387
95Adrenal overactivity (HP:0002717)2.07188447
96Apathy (HP:0000741)2.06764830
97Dysautonomia (HP:0002459)2.05945381
98Hand muscle atrophy (HP:0009130)2.05730351
99Intention tremor (HP:0002080)2.03723705
100Prolonged QT interval (HP:0001657)2.03507849
101Abnormality of the motor neurons (HP:0002450)2.02744550
102Abnormal neuron morphology (HP:0012757)2.02744550
103Urinary urgency (HP:0000012)2.02691702
104Bilateral microphthalmos (HP:0007633)2.02682941
105Abnormality of oral frenula (HP:0000190)2.02411648
106Shoulder girdle muscle weakness (HP:0003547)2.01918258
107Hyperparathyroidism (HP:0000843)2.01537880
108Complement deficiency (HP:0004431)2.01271293
109Abnormality of the vitreous humor (HP:0004327)2.00631994
110Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00505339
111Turricephaly (HP:0000262)2.00390399
112Urinary bladder sphincter dysfunction (HP:0002839)2.00267435
113Abnormal vertebral ossification (HP:0100569)1.98421412
114Gout (HP:0001997)1.98380966
115Dysdiadochokinesis (HP:0002075)1.98258862
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97720441
117Polyphagia (HP:0002591)1.97375400
118Glioma (HP:0009733)1.96429444
119Aplasia/hypoplasia of the humerus (HP:0006507)1.96395908
120Horizontal nystagmus (HP:0000666)1.95931670
121Bowing of the arm (HP:0006488)1.94123198
122Bowed forearm bones (HP:0003956)1.94123198
123Aplasia of the musculature (HP:0100854)1.93900320
124Testicular atrophy (HP:0000029)1.93241444
125Abnormal tarsal ossification (HP:0008369)1.92102637
126Supernumerary spleens (HP:0009799)1.91971498
127Hypokinesia (HP:0002375)1.91844757
128Abnormal eating behavior (HP:0100738)1.91530542
129Supranuclear gaze palsy (HP:0000605)1.91420549
130Rectovaginal fistula (HP:0000143)1.90831056
131Rectal fistula (HP:0100590)1.90831056
132Spinal cord compression (HP:0002176)1.88938018
133Ankle clonus (HP:0011448)1.88799111
134Enlarged penis (HP:0000040)1.87827352
135Bulbar palsy (HP:0001283)1.87623100
136Reticulocytosis (HP:0001923)1.86462505
137Aplasia/hypoplasia of the femur (HP:0005613)1.85704015
138Tented upper lip vermilion (HP:0010804)1.85606333
139Cerebral aneurysm (HP:0004944)1.85066340
140Epiphyseal dysplasia (HP:0002656)1.84648524
141Septate vagina (HP:0001153)1.84575194
142Abnormality of the acetabulum (HP:0003170)1.84324596
143Vaginal fistula (HP:0004320)1.83777386
144Broad palm (HP:0001169)1.83767892
145Neoplasm of striated muscle (HP:0009728)1.83616549
146Achilles tendon contracture (HP:0001771)1.83343811
147Diminished motivation (HP:0000745)1.82947010
148Spastic tetraparesis (HP:0001285)1.82570435
149Shallow orbits (HP:0000586)1.82372114
150Hypoventilation (HP:0002791)1.82247588
151Generalized tonic-clonic seizures (HP:0002069)1.81676392
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79957989
153Sleep apnea (HP:0010535)1.79760495
154Impaired social interactions (HP:0000735)1.79026823
155Abnormal social behavior (HP:0012433)1.79026823
156Abnormality of the labia (HP:0000058)1.78928647
157Thin bony cortex (HP:0002753)1.78881035
158Distal sensory impairment (HP:0002936)1.78776792
159Abnormality of complement system (HP:0005339)1.77770042
160Fasciculations (HP:0002380)1.77732181
161Vertebral compression fractures (HP:0002953)1.77073488
162Limb hypertonia (HP:0002509)1.77040203
163Mitral stenosis (HP:0001718)1.76908961
164Delusions (HP:0000746)1.76842724
16511 pairs of ribs (HP:0000878)1.75873565
166Short femoral neck (HP:0100864)1.75029676
167Deviation of the thumb (HP:0009603)1.74700139
168Abnormality of chromosome segregation (HP:0002916)1.73670224
169Generalized myoclonic seizures (HP:0002123)1.73581782
170Narrow nasal bridge (HP:0000446)1.73014252
171Choanal stenosis (HP:0000452)1.71498024
172Barrel-shaped chest (HP:0001552)1.71029777
173Paraparesis (HP:0002385)1.70138626
174Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.66932582
175Alacrima (HP:0000522)1.65492525
176Widely patent fontanelles and sutures (HP:0004492)1.62633435
177Advanced eruption of teeth (HP:0006288)1.61808646
178Abnormality of the musculature of the hand (HP:0001421)1.59781567
179Subcapsular cataract (HP:0000523)1.59768874
180Cerebral inclusion bodies (HP:0100314)1.59673021
181Abnormal gallbladder physiology (HP:0012438)1.59129298
182Cholecystitis (HP:0001082)1.59129298
183Abnormality of the middle phalanges of the toes (HP:0010183)1.58654914
184Polar cataract (HP:0010696)1.57544499
185Glomerulonephritis (HP:0000099)1.57123471
186Small epiphyses (HP:0010585)1.55087137
187Testicular neoplasm (HP:0010788)1.54506821
188Facial shape deformation (HP:0011334)1.52178409
189Potter facies (HP:0002009)1.52178409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.45128983
2MST1R5.24559896
3MAP3K94.66884166
4FGFR44.50502738
5NTRK34.13773815
6SIK14.10795348
7TRIB33.64639897
8EPHA43.24112761
9IRAK33.10376417
10TAOK23.01055734
11TYRO32.78629786
12CAMK1D2.68937008
13CDK122.64329317
14EEF2K2.50286312
15ICK2.42130328
16MET2.38931366
17SMG12.30708326
18ERN12.30373799
19NTRK12.16240466
20DDR22.11913289
21WNK42.11789827
22KSR22.09297597
23MINK12.09292549
24GRK72.08700406
25UHMK11.92655031
26MATK1.88390688
27LATS21.84829681
28MAP2K61.78022313
29CAMK1G1.75602647
30MAP3K111.74024820
31RIPK11.72233366
32PAK61.71380713
33AKT31.69761785
34FGR1.60230233
35NTRK21.54781546
36DAPK11.50995215
37NEK11.45788400
38BMX1.42103696
39GRK51.39431600
40PIM21.37408965
41PKN21.31894465
42IRAK21.28580894
43ARAF1.23502140
44MAPK151.20322648
45PAK41.18294060
46ALK1.14970397
47FGFR31.14905381
48PINK11.11898937
49MTOR1.11142344
50CDK71.10089488
51SCYL21.06821997
52NME21.06095460
53KSR11.04380742
54PTK61.03878867
55DAPK21.03186300
56PLK11.01042765
57CDK51.00741830
58WEE11.00228992
59WNK10.99854254
60CAMKK10.99336454
61HIPK20.97525403
62MAP3K120.96172648
63PTK20.95738854
64FGFR10.88350329
65MAP2K40.86893347
66CAMK40.86177585
67DYRK1B0.85256511
68CAMK2G0.83358392
69TTN0.83344037
70LMTK20.81490353
71PNCK0.81284225
72MAP3K60.81175743
73MAP3K20.80130483
74PHKG20.78466743
75PHKG10.78466743
76PRKD20.77864092
77CDK150.77468666
78MARK10.75010854
79PRKD30.74796650
80MAP3K100.74687346
81CDK180.74551806
82PRPF4B0.73879493
83PRKCG0.73665576
84FGFR20.73411019
85CDC42BPA0.73320917
86PAK30.72013574
87CDK11A0.71711885
88CDK140.70950339
89CDK80.70867065
90STK380.69946709
91MAPK100.67780193
92ADRBK10.67604025
93PRKAA20.66999376
94BRSK10.64665483
95CAMK2A0.64075660
96GRK60.61374902
97RAF10.61317520
98MAPK110.60830235
99MOS0.59197976
100SGK10.58877270
101TNK20.58713081
102TESK20.58325909
103TAOK10.57441931
104SIK20.56338539
105PDPK10.54150094
106RPS6KA30.53375071
107CDK90.53272622
108DYRK30.52947595
109CSNK1E0.52856027
110MARK20.52735354
111STK390.51426711
112FES0.51087489
113MAP3K50.49992554
114PRKCI0.49929349
115TESK10.49453688
116MAP3K130.47116880
117PDK10.46487194
118MUSK0.45255500
119RPS6KL10.44990224
120RPS6KC10.44990224
121SGK4940.44472973
122SGK2230.44472973
123GSK3A0.42995727
124MAP3K70.42734402
125PRKAA10.42548823
126PRKG20.42508404
127CHEK20.42329251
128MAP3K80.42278904
129PDGFRA0.42119972
130PRKACG0.41642195
131MAP2K10.41604155
132CDK40.40740577
133PDK40.39903374
134PDK30.39903374
135SGK30.39223613
136RPS6KA10.39155983
137SGK20.39085813
138FER0.38725425
139AKT20.36868445
140BRAF0.36818449
141ERBB40.36397447
142NME10.34682257
143EPHB10.30598197
144BRD40.27503557
145NEK20.26708731
146MAP3K10.23785722
147MAP3K30.22017537
148CSF1R0.21747392
149IRAK40.21675658
150AURKA0.21292727
151ERBB20.21150000
152EIF2AK10.19743632
153CDK10.19714625
154MAPK80.19381212
155CHUK0.17629892
156LRRK20.16906836
157IRAK10.16573985
158GSK3B0.14964964
159ILK0.14414748
160PRKD10.14019024

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.32799121
2Complement and coagulation cascades_Homo sapiens_hsa046103.27248646
3Synaptic vesicle cycle_Homo sapiens_hsa047212.71404640
4Amphetamine addiction_Homo sapiens_hsa050312.64677518
5Olfactory transduction_Homo sapiens_hsa047402.62740167
6Nicotine addiction_Homo sapiens_hsa050332.45736025
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.45385545
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42909791
9GABAergic synapse_Homo sapiens_hsa047272.33237384
10Long-term potentiation_Homo sapiens_hsa047202.31493686
11Arginine and proline metabolism_Homo sapiens_hsa003302.23943503
12Vitamin B6 metabolism_Homo sapiens_hsa007502.22652518
13Cocaine addiction_Homo sapiens_hsa050302.21413108
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.19146382
15Other glycan degradation_Homo sapiens_hsa005112.15451889
16Dopaminergic synapse_Homo sapiens_hsa047282.11891878
17Sulfur relay system_Homo sapiens_hsa041221.96030111
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.90318147
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88959335
20Phenylalanine metabolism_Homo sapiens_hsa003601.88192229
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87864259
22Circadian entrainment_Homo sapiens_hsa047131.85799930
23Insulin secretion_Homo sapiens_hsa049111.83990322
24Morphine addiction_Homo sapiens_hsa050321.83140359
25Steroid biosynthesis_Homo sapiens_hsa001001.79607331
26Vitamin digestion and absorption_Homo sapiens_hsa049771.78900171
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.78335187
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.76495270
29GnRH signaling pathway_Homo sapiens_hsa049121.76419678
30Pyruvate metabolism_Homo sapiens_hsa006201.75768756
31Oocyte meiosis_Homo sapiens_hsa041141.71555499
32Long-term depression_Homo sapiens_hsa047301.71036528
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68089867
34Histidine metabolism_Homo sapiens_hsa003401.67854472
35Glutamatergic synapse_Homo sapiens_hsa047241.62297806
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62136388
37Renin secretion_Homo sapiens_hsa049241.60489168
38Fatty acid metabolism_Homo sapiens_hsa012121.59398653
39PPAR signaling pathway_Homo sapiens_hsa033201.57270392
40Gap junction_Homo sapiens_hsa045401.56887617
41Fat digestion and absorption_Homo sapiens_hsa049751.55242918
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.53185444
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.52932619
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52930848
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50551637
46Lysine degradation_Homo sapiens_hsa003101.48490297
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46541148
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42353898
49Cholinergic synapse_Homo sapiens_hsa047251.41333129
50Salivary secretion_Homo sapiens_hsa049701.39650670
51Dorso-ventral axis formation_Homo sapiens_hsa043201.37440388
52Renin-angiotensin system_Homo sapiens_hsa046141.36942051
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36184889
54Prion diseases_Homo sapiens_hsa050201.35594967
55Gastric acid secretion_Homo sapiens_hsa049711.30521351
56Serotonergic synapse_Homo sapiens_hsa047261.29141275
57Carbon metabolism_Homo sapiens_hsa012001.29060457
58Bladder cancer_Homo sapiens_hsa052191.26643646
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20913345
60N-Glycan biosynthesis_Homo sapiens_hsa005101.18580706
61Estrogen signaling pathway_Homo sapiens_hsa049151.18203370
62Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15783347
63mTOR signaling pathway_Homo sapiens_hsa041501.14983635
64ABC transporters_Homo sapiens_hsa020101.14543307
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13560506
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13415410
67Collecting duct acid secretion_Homo sapiens_hsa049661.12607591
68Oxytocin signaling pathway_Homo sapiens_hsa049211.11985973
69Vibrio cholerae infection_Homo sapiens_hsa051101.10193156
70Taste transduction_Homo sapiens_hsa047421.09272966
71Melanogenesis_Homo sapiens_hsa049161.07259066
72AMPK signaling pathway_Homo sapiens_hsa041521.05606256
73Sphingolipid metabolism_Homo sapiens_hsa006001.04832151
74ECM-receptor interaction_Homo sapiens_hsa045121.03297002
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03172082
76One carbon pool by folate_Homo sapiens_hsa006701.03063579
77Fatty acid degradation_Homo sapiens_hsa000711.01137550
78Fructose and mannose metabolism_Homo sapiens_hsa000511.00528991
79Glioma_Homo sapiens_hsa052141.00018354
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98248783
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97596396
82Type I diabetes mellitus_Homo sapiens_hsa049400.97274359
83Thyroid cancer_Homo sapiens_hsa052160.96629902
84Graft-versus-host disease_Homo sapiens_hsa053320.93940693
85Insulin resistance_Homo sapiens_hsa049310.92131593
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91743598
87Fatty acid biosynthesis_Homo sapiens_hsa000610.90545116
88VEGF signaling pathway_Homo sapiens_hsa043700.84086111
89Calcium signaling pathway_Homo sapiens_hsa040200.84009784
90Tyrosine metabolism_Homo sapiens_hsa003500.80281128
91MAPK signaling pathway_Homo sapiens_hsa040100.78586118
92ErbB signaling pathway_Homo sapiens_hsa040120.78015461
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74939221
94Thyroid hormone synthesis_Homo sapiens_hsa049180.74807236
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.73736546
96Hippo signaling pathway_Homo sapiens_hsa043900.73697649
97Hedgehog signaling pathway_Homo sapiens_hsa043400.72170185
98Pentose phosphate pathway_Homo sapiens_hsa000300.71400423
99* cAMP signaling pathway_Homo sapiens_hsa040240.71347504
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.70557925
101Basal cell carcinoma_Homo sapiens_hsa052170.70500319
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69740968
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.69460725
104Rap1 signaling pathway_Homo sapiens_hsa040150.69376315
105Non-small cell lung cancer_Homo sapiens_hsa052230.68886305
106Glucagon signaling pathway_Homo sapiens_hsa049220.68455598
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66376954
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.66138702
109Tight junction_Homo sapiens_hsa045300.65256375
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65184627
111Cardiac muscle contraction_Homo sapiens_hsa042600.64846563
112Biosynthesis of amino acids_Homo sapiens_hsa012300.64584605
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64390560
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.63517388
115Alcoholism_Homo sapiens_hsa050340.62682487
116Sulfur metabolism_Homo sapiens_hsa009200.62403720
117Starch and sucrose metabolism_Homo sapiens_hsa005000.61355550
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61037507
119Galactose metabolism_Homo sapiens_hsa000520.59695957
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.57752642
121* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57167009
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56356746
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54976257
124Proteoglycans in cancer_Homo sapiens_hsa052050.53074835
125Choline metabolism in cancer_Homo sapiens_hsa052310.52618274
126Chronic myeloid leukemia_Homo sapiens_hsa052200.52095555
127Arginine biosynthesis_Homo sapiens_hsa002200.51552641
128mRNA surveillance pathway_Homo sapiens_hsa030150.50824153
129Dilated cardiomyopathy_Homo sapiens_hsa054140.50778083
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49916277
131Selenocompound metabolism_Homo sapiens_hsa004500.49402551
132Focal adhesion_Homo sapiens_hsa045100.49001177
133Cysteine and methionine metabolism_Homo sapiens_hsa002700.48153468
134Wnt signaling pathway_Homo sapiens_hsa043100.46803631
135Notch signaling pathway_Homo sapiens_hsa043300.46369127
136Endometrial cancer_Homo sapiens_hsa052130.46254775
137Circadian rhythm_Homo sapiens_hsa047100.44363832
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43953769
139RNA transport_Homo sapiens_hsa030130.43606873
140Adherens junction_Homo sapiens_hsa045200.42860104
141Nitrogen metabolism_Homo sapiens_hsa009100.41514748
142Glycerolipid metabolism_Homo sapiens_hsa005610.41351579
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40498904
144Mismatch repair_Homo sapiens_hsa034300.40079273
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39978268
146Bile secretion_Homo sapiens_hsa049760.39686997
147Prostate cancer_Homo sapiens_hsa052150.38395300
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.38370964
149Small cell lung cancer_Homo sapiens_hsa052220.38358075
150Pancreatic secretion_Homo sapiens_hsa049720.37614002
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37340664
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36986133
153Axon guidance_Homo sapiens_hsa043600.36717541
154Insulin signaling pathway_Homo sapiens_hsa049100.36583121
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.31006216
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30735460
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30242506
158Type II diabetes mellitus_Homo sapiens_hsa049300.27974634
159Metabolic pathways_Homo sapiens_hsa011000.26966398
160Glutathione metabolism_Homo sapiens_hsa004800.26631670
161Peroxisome_Homo sapiens_hsa041460.24938274
162Ovarian steroidogenesis_Homo sapiens_hsa049130.22237477
163Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20591577
164Acute myeloid leukemia_Homo sapiens_hsa052210.16581785

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