

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.15978078 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.99011726 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 4.96277365 |
| 4 | DNA deamination (GO:0045006) | 4.82005771 |
| 5 | ATP synthesis coupled proton transport (GO:0015986) | 4.75889505 |
| 6 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.75889505 |
| 7 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.67662329 |
| 8 | termination of RNA polymerase III transcription (GO:0006386) | 4.67662329 |
| 9 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.61843345 |
| 10 | ribosomal small subunit biogenesis (GO:0042274) | 4.43213179 |
| 11 | cullin deneddylation (GO:0010388) | 4.35687055 |
| 12 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.29710433 |
| 13 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.28696731 |
| 14 | maturation of SSU-rRNA (GO:0030490) | 4.28660130 |
| 15 | protein deneddylation (GO:0000338) | 4.25335669 |
| 16 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 4.23209404 |
| 17 | protein neddylation (GO:0045116) | 4.21025225 |
| 18 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.17767513 |
| 19 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.17589903 |
| 20 | negative regulation of ligase activity (GO:0051352) | 4.16893733 |
| 21 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.16893733 |
| 22 | viral transcription (GO:0019083) | 4.15507309 |
| 23 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.08994057 |
| 24 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.08994057 |
| 25 | translational termination (GO:0006415) | 4.08817659 |
| 26 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.07455053 |
| 27 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.06005037 |
| 28 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.06005037 |
| 29 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.06005037 |
| 30 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 4.05698049 |
| 31 | chaperone-mediated protein transport (GO:0072321) | 4.05252537 |
| 32 | protein maturation by protein folding (GO:0022417) | 4.04722356 |
| 33 | 7-methylguanosine mRNA capping (GO:0006370) | 3.93788953 |
| 34 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.93654197 |
| 35 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.93261862 |
| 36 | cotranslational protein targeting to membrane (GO:0006613) | 3.91529661 |
| 37 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.91091632 |
| 38 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.91091632 |
| 39 | RNA capping (GO:0036260) | 3.87460681 |
| 40 | 7-methylguanosine RNA capping (GO:0009452) | 3.87460681 |
| 41 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.86765464 |
| 42 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.84988936 |
| 43 | protein targeting to ER (GO:0045047) | 3.84210296 |
| 44 | protein complex biogenesis (GO:0070271) | 3.83108422 |
| 45 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.81777978 |
| 46 | NADH dehydrogenase complex assembly (GO:0010257) | 3.81777978 |
| 47 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.81777978 |
| 48 | formation of translation preinitiation complex (GO:0001731) | 3.76719677 |
| 49 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.75461754 |
| 50 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.72575911 |
| 51 | oxidative phosphorylation (GO:0006119) | 3.72448329 |
| 52 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.70258745 |
| 53 | protein localization to endoplasmic reticulum (GO:0070972) | 3.69600075 |
| 54 | translation (GO:0006412) | 3.69578136 |
| 55 | ribosomal large subunit biogenesis (GO:0042273) | 3.69163530 |
| 56 | translational elongation (GO:0006414) | 3.62696120 |
| 57 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.62101125 |
| 58 | positive regulation of ligase activity (GO:0051351) | 3.61257690 |
| 59 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.58559650 |
| 60 | respiratory electron transport chain (GO:0022904) | 3.53536375 |
| 61 | translational initiation (GO:0006413) | 3.48552194 |
| 62 | electron transport chain (GO:0022900) | 3.45819634 |
| 63 | protein targeting to mitochondrion (GO:0006626) | 3.41030919 |
| 64 | viral life cycle (GO:0019058) | 3.37109014 |
| 65 | regulation of mitochondrial translation (GO:0070129) | 3.36539894 |
| 66 | establishment of protein localization to mitochondrion (GO:0072655) | 3.35934298 |
| 67 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.35525508 |
| 68 | respiratory chain complex IV assembly (GO:0008535) | 3.32686359 |
| 69 | cellular protein complex disassembly (GO:0043624) | 3.31480231 |
| 70 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 3.30486703 |
| 71 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.30370920 |
| 72 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.29350425 |
| 73 | viral mRNA export from host cell nucleus (GO:0046784) | 3.26424488 |
| 74 | rRNA modification (GO:0000154) | 3.25286841 |
| 75 | cellular component biogenesis (GO:0044085) | 3.24334971 |
| 76 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.23597469 |
| 77 | regulation of cellular amine metabolic process (GO:0033238) | 3.23197453 |
| 78 | GDP-mannose metabolic process (GO:0019673) | 3.23164476 |
| 79 | DNA strand elongation (GO:0022616) | 3.22415338 |
| 80 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.22142705 |
| 81 | inner mitochondrial membrane organization (GO:0007007) | 3.21833790 |
| 82 | GTP biosynthetic process (GO:0006183) | 3.21257888 |
| 83 | positive regulation of cell cycle arrest (GO:0071158) | 3.19753765 |
| 84 | transcription from mitochondrial promoter (GO:0006390) | 3.19652786 |
| 85 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.17867519 |
| 86 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.17867519 |
| 87 | spliceosomal snRNP assembly (GO:0000387) | 3.17750577 |
| 88 | pseudouridine synthesis (GO:0001522) | 3.16103423 |
| 89 | base-excision repair, AP site formation (GO:0006285) | 3.15521792 |
| 90 | regulation of ligase activity (GO:0051340) | 3.13983843 |
| 91 | L-methionine salvage (GO:0071267) | 3.13495196 |
| 92 | L-methionine biosynthetic process (GO:0071265) | 3.13495196 |
| 93 | amino acid salvage (GO:0043102) | 3.13495196 |
| 94 | autophagic vacuole fusion (GO:0000046) | 3.13490058 |
| 95 | cytochrome complex assembly (GO:0017004) | 3.13412442 |
| 96 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.13190261 |
| 97 | protein localization to mitochondrion (GO:0070585) | 3.13007741 |
| 98 | peptidyl-histidine modification (GO:0018202) | 3.11317026 |
| 99 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.10516601 |
| 100 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.10105423 |
| 101 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.09930304 |
| 102 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.05879148 |
| 103 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.05500591 |
| 104 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.05051517 |
| 105 | rRNA processing (GO:0006364) | 3.03721462 |
| 106 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.02449476 |
| 107 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.02061466 |
| 108 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.00611284 |
| 109 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.00611284 |
| 110 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.00199919 |
| 111 | CTP biosynthetic process (GO:0006241) | 2.97816912 |
| 112 | CTP metabolic process (GO:0046036) | 2.97816912 |
| 113 | rRNA methylation (GO:0031167) | 2.97694152 |
| 114 | maturation of 5.8S rRNA (GO:0000460) | 2.97613507 |
| 115 | DNA replication checkpoint (GO:0000076) | 2.97334212 |
| 116 | UTP biosynthetic process (GO:0006228) | 2.96322813 |
| 117 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.94948015 |
| 118 | intracellular protein transmembrane import (GO:0044743) | 2.93983955 |
| 119 | rRNA metabolic process (GO:0016072) | 2.91466775 |
| 120 | deoxyribonucleotide catabolic process (GO:0009264) | 2.89694194 |
| 121 | establishment of integrated proviral latency (GO:0075713) | 2.89019212 |
| 122 | mitochondrial transport (GO:0006839) | 2.88107766 |
| 123 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.87821790 |
| 124 | intracellular protein transmembrane transport (GO:0065002) | 2.87572855 |
| 125 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.87518635 |
| 126 | telomere maintenance via recombination (GO:0000722) | 2.85542806 |
| 127 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.85060926 |
| 128 | ribosome biogenesis (GO:0042254) | 2.83335772 |
| 129 | telomere maintenance via telomere lengthening (GO:0010833) | 2.82021381 |
| 130 | mannosylation (GO:0097502) | 2.81812913 |
| 131 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.80768590 |
| 132 | protein K6-linked ubiquitination (GO:0085020) | 2.80139609 |
| 133 | ATP biosynthetic process (GO:0006754) | 2.78735378 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.88958002 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.77111620 |
| 3 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.28521049 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.27136042 |
| 5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.87588014 |
| 6 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.76747903 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.56294304 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.56284066 |
| 9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.52393004 |
| 10 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.40270699 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.11409756 |
| 12 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.09087087 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.08287565 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.07929533 |
| 15 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.98979797 |
| 16 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.96264979 |
| 17 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.93343114 |
| 18 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.87983673 |
| 19 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.80271332 |
| 20 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.62616249 |
| 21 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.51466676 |
| 22 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.49024253 |
| 23 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.44115999 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.41160115 |
| 25 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.30505994 |
| 26 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.28620522 |
| 27 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.27882869 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.26480864 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.26278835 |
| 30 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.19192748 |
| 31 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.17187107 |
| 32 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.13922050 |
| 33 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.08620954 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.07334856 |
| 35 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.97320594 |
| 36 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.93548513 |
| 37 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.90718056 |
| 38 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.87560686 |
| 39 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.80214537 |
| 40 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.73651314 |
| 41 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.68902482 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.66937804 |
| 43 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.66359253 |
| 44 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.60376069 |
| 45 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.57282820 |
| 46 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.55493508 |
| 47 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.51386072 |
| 48 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.49032570 |
| 49 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.48833831 |
| 50 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.48650699 |
| 51 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.47473557 |
| 52 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.46466625 |
| 53 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.42332420 |
| 54 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.40431734 |
| 55 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.40369925 |
| 56 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37334807 |
| 57 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.36042679 |
| 58 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.35076338 |
| 59 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.35023696 |
| 60 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.32317207 |
| 61 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.32245191 |
| 62 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.31350476 |
| 63 | MYC_22102868_ChIP-Seq_BL_Human | 1.31300275 |
| 64 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.30372887 |
| 65 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.30019833 |
| 66 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.27480811 |
| 67 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27477943 |
| 68 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.24800523 |
| 69 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.24746344 |
| 70 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.23336257 |
| 71 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.23239022 |
| 72 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.22768028 |
| 73 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.18054985 |
| 74 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.16852861 |
| 75 | * P68_20966046_ChIP-Seq_HELA_Human | 1.16769159 |
| 76 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.16526802 |
| 77 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.16457064 |
| 78 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.14075124 |
| 79 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.13402147 |
| 80 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.06916073 |
| 81 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.05616348 |
| 82 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.04484974 |
| 83 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.04401130 |
| 84 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.03926456 |
| 85 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.02394043 |
| 86 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.01377255 |
| 87 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.00615951 |
| 88 | * PHF8_20622854_ChIP-Seq_HELA_Human | 1.00491128 |
| 89 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.00481818 |
| 90 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 1.00303294 |
| 91 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.00185985 |
| 92 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.00127521 |
| 93 | * SA1_27219007_Chip-Seq_Bcells_Human | 0.98822370 |
| 94 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.97170473 |
| 95 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.95948316 |
| 96 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.95602743 |
| 97 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.94322863 |
| 98 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.93719530 |
| 99 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.93384997 |
| 100 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.93002717 |
| 101 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.92314168 |
| 102 | * MAF_26560356_Chip-Seq_TH2_Human | 0.92099596 |
| 103 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.91936895 |
| 104 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.91906310 |
| 105 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.91723169 |
| 106 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.90575888 |
| 107 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.88561141 |
| 108 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.86773566 |
| 109 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.85741471 |
| 110 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.85368244 |
| 111 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.85361815 |
| 112 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.84736087 |
| 113 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.84003734 |
| 114 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.83949479 |
| 115 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.79184690 |
| 116 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.78611238 |
| 117 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.78197735 |
| 118 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.76938836 |
| 119 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.75602313 |
| 120 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.75331044 |
| 121 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.75084487 |
| 122 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.72885921 |
| 123 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.72065539 |
| 124 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.70984593 |
| 125 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.67355687 |
| 126 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.66567985 |
| 127 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.65359771 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.37990066 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 3.10197885 |
| 3 | MP0003186_abnormal_redox_activity | 2.70909952 |
| 4 | MP0001835_abnormal_antigen_presentation | 2.56655752 |
| 5 | MP0009785_altered_susceptibility_to | 2.51820735 |
| 6 | MP0004147_increased_porphyrin_level | 2.50636136 |
| 7 | MP0002148_abnormal_hypersensitivity_rea | 2.44935559 |
| 8 | MP0003718_maternal_effect | 2.42612001 |
| 9 | MP0005671_abnormal_response_to | 2.41739514 |
| 10 | MP0008058_abnormal_DNA_repair | 2.41489308 |
| 11 | MP0008057_abnormal_DNA_replication | 2.35797564 |
| 12 | MP0003077_abnormal_cell_cycle | 2.34527265 |
| 13 | MP0009379_abnormal_foot_pigmentation | 2.31897236 |
| 14 | MP0010094_abnormal_chromosome_stability | 2.29465950 |
| 15 | MP0002163_abnormal_gland_morphology | 2.28394913 |
| 16 | MP0008260_abnormal_autophagy | 2.16617982 |
| 17 | MP0008932_abnormal_embryonic_tissue | 2.13345040 |
| 18 | MP0001529_abnormal_vocalization | 2.13344795 |
| 19 | MP0009333_abnormal_splenocyte_physiolog | 2.10429022 |
| 20 | MP0001986_abnormal_taste_sensitivity | 2.08280857 |
| 21 | MP0003172_abnormal_lysosome_physiology | 2.04547244 |
| 22 | MP0003111_abnormal_nucleus_morphology | 1.97459629 |
| 23 | MP0003878_abnormal_ear_physiology | 1.96708084 |
| 24 | MP0005377_hearing/vestibular/ear_phenot | 1.96708084 |
| 25 | MP0001873_stomach_inflammation | 1.91399996 |
| 26 | MP0003786_premature_aging | 1.89900365 |
| 27 | MP0006035_abnormal_mitochondrial_morpho | 1.86144711 |
| 28 | MP0002132_abnormal_respiratory_system | 1.86076816 |
| 29 | MP0006036_abnormal_mitochondrial_physio | 1.84101034 |
| 30 | MP0001905_abnormal_dopamine_level | 1.79230157 |
| 31 | MP0000372_irregular_coat_pigmentation | 1.79179766 |
| 32 | MP0003880_abnormal_central_pattern | 1.75212227 |
| 33 | MP0003806_abnormal_nucleotide_metabolis | 1.72510046 |
| 34 | MP0002837_dystrophic_cardiac_calcinosis | 1.71031438 |
| 35 | MP0002638_abnormal_pupillary_reflex | 1.68598435 |
| 36 | MP0005000_abnormal_immune_tolerance | 1.65253399 |
| 37 | MP0003436_decreased_susceptibility_to | 1.62305650 |
| 38 | MP0005025_abnormal_response_to | 1.62214116 |
| 39 | MP0008995_early_reproductive_senescence | 1.57754457 |
| 40 | MP0009840_abnormal_foam_cell | 1.56989479 |
| 41 | MP0008872_abnormal_physiological_respon | 1.50485121 |
| 42 | MP0003123_paternal_imprinting | 1.50280429 |
| 43 | MP0001853_heart_inflammation | 1.49334634 |
| 44 | MP0002277_abnormal_respiratory_mucosa | 1.45398420 |
| 45 | MP0001542_abnormal_bone_strength | 1.44388195 |
| 46 | MP0002723_abnormal_immune_serum | 1.43026067 |
| 47 | MP0000490_abnormal_crypts_of | 1.41829308 |
| 48 | MP0005636_abnormal_mineral_homeostasis | 1.38572335 |
| 49 | MP0005451_abnormal_body_composition | 1.37955729 |
| 50 | MP0002396_abnormal_hematopoietic_system | 1.37523558 |
| 51 | MP0002420_abnormal_adaptive_immunity | 1.35688877 |
| 52 | MP0009278_abnormal_bone_marrow | 1.35587673 |
| 53 | MP0001819_abnormal_immune_cell | 1.35524285 |
| 54 | MP0002452_abnormal_antigen_presenting | 1.34362644 |
| 55 | MP0003763_abnormal_thymus_physiology | 1.34136201 |
| 56 | MP0008877_abnormal_DNA_methylation | 1.31863346 |
| 57 | MP0002419_abnormal_innate_immunity | 1.30757625 |
| 58 | MP0001984_abnormal_olfaction | 1.30647532 |
| 59 | MP0005084_abnormal_gallbladder_morpholo | 1.30222520 |
| 60 | MP0001727_abnormal_embryo_implantation | 1.28952335 |
| 61 | MP0001800_abnormal_humoral_immune | 1.28559139 |
| 62 | MP0000685_abnormal_immune_system | 1.28448503 |
| 63 | MP0002102_abnormal_ear_morphology | 1.27440810 |
| 64 | MP0006082_CNS_inflammation | 1.27316582 |
| 65 | MP0005075_abnormal_melanosome_morpholog | 1.26395555 |
| 66 | MP0005646_abnormal_pituitary_gland | 1.25982865 |
| 67 | MP0001764_abnormal_homeostasis | 1.25049455 |
| 68 | MP0002693_abnormal_pancreas_physiology | 1.21467454 |
| 69 | MP0003724_increased_susceptibility_to | 1.21445037 |
| 70 | MP0002405_respiratory_system_inflammati | 1.21392030 |
| 71 | MP0002938_white_spotting | 1.19899721 |
| 72 | MP0006292_abnormal_olfactory_placode | 1.19228270 |
| 73 | MP0002736_abnormal_nociception_after | 1.19084685 |
| 74 | MP0000358_abnormal_cell_content/ | 1.18741005 |
| 75 | MP0005171_absent_coat_pigmentation | 1.18678032 |
| 76 | MP0008007_abnormal_cellular_replicative | 1.17085437 |
| 77 | MP0005408_hypopigmentation | 1.16609269 |
| 78 | MP0006276_abnormal_autonomic_nervous | 1.15364329 |
| 79 | MP0004145_abnormal_muscle_electrophysio | 1.12548476 |
| 80 | MP0002398_abnormal_bone_marrow | 1.12143123 |
| 81 | MP0001790_abnormal_immune_system | 1.10069680 |
| 82 | MP0005387_immune_system_phenotype | 1.10069680 |
| 83 | MP0009697_abnormal_copulation | 1.08830628 |
| 84 | MP0003136_yellow_coat_color | 1.08791657 |
| 85 | MP0008789_abnormal_olfactory_epithelium | 1.08383335 |
| 86 | MP0000716_abnormal_immune_system | 1.08041010 |
| 87 | MP0005058_abnormal_lysosome_morphology | 1.07998759 |
| 88 | MP0000689_abnormal_spleen_morphology | 1.05872101 |
| 89 | MP0001944_abnormal_pancreas_morphology | 1.05491816 |
| 90 | MP0010386_abnormal_urinary_bladder | 1.03701112 |
| 91 | MP0002095_abnormal_skin_pigmentation | 1.02950619 |
| 92 | MP0000343_altered_response_to | 1.02244140 |
| 93 | MP0001545_abnormal_hematopoietic_system | 1.01955062 |
| 94 | MP0005397_hematopoietic_system_phenotyp | 1.01955062 |
| 95 | MP0005379_endocrine/exocrine_gland_phen | 1.01407255 |
| 96 | MP0002722_abnormal_immune_system | 1.00686215 |
| 97 | MP0002429_abnormal_blood_cell | 1.00588673 |
| 98 | MP0000313_abnormal_cell_death | 0.99993943 |
| 99 | MP0002138_abnormal_hepatobiliary_system | 0.99817040 |
| 100 | MP0005332_abnormal_amino_acid | 0.99307005 |
| 101 | MP0001188_hyperpigmentation | 0.95925348 |
| 102 | MP0003315_abnormal_perineum_morphology | 0.95325727 |
| 103 | MP0002735_abnormal_chemical_nociception | 0.92724135 |
| 104 | MP0001845_abnormal_inflammatory_respons | 0.92251827 |
| 105 | MP0003075_altered_response_to | 0.91472335 |
| 106 | MP0005310_abnormal_salivary_gland | 0.90412564 |
| 107 | MP0000703_abnormal_thymus_morphology | 0.88847477 |
| 108 | MP0000015_abnormal_ear_pigmentation | 0.88378026 |
| 109 | MP0001730_embryonic_growth_arrest | 0.87666689 |
| 110 | MP0008469_abnormal_protein_level | 0.86719452 |
| 111 | MP0004381_abnormal_hair_follicle | 0.86520018 |
| 112 | MP0005174_abnormal_tail_pigmentation | 0.85701166 |
| 113 | MP0002876_abnormal_thyroid_physiology | 0.85508467 |
| 114 | MP0000858_altered_metastatic_potential | 0.83495578 |
| 115 | MP0002822_catalepsy | 0.83400712 |
| 116 | MP0003866_abnormal_defecation | 0.83120937 |
| 117 | MP0002234_abnormal_pharynx_morphology | 0.83071275 |
| 118 | MP0003011_delayed_dark_adaptation | 0.82934374 |
| 119 | MP0002019_abnormal_tumor_incidence | 0.82402950 |
| 120 | MP0002909_abnormal_adrenal_gland | 0.82260388 |
| 121 | MP0004782_abnormal_surfactant_physiolog | 0.82219538 |
| 122 | MP0005464_abnormal_platelet_physiology | 0.80409879 |
| 123 | MP0000371_diluted_coat_color | 0.79824758 |
| 124 | MP0002653_abnormal_ependyma_morphology | 0.79595423 |
| 125 | MP0000350_abnormal_cell_proliferation | 0.79410176 |
| 126 | MP0003646_muscle_fatigue | 0.79169145 |
| 127 | MP0004142_abnormal_muscle_tone | 0.78796977 |
| 128 | MP0001663_abnormal_digestive_system | 0.78659961 |
| 129 | MP0002160_abnormal_reproductive_system | 0.77752354 |
| 130 | MP0005220_abnormal_exocrine_pancreas | 0.77357497 |
| 131 | MP0009672_abnormal_birth_weight | 0.76200217 |
| 132 | MP0004043_abnormal_pH_regulation | 0.74852410 |
| 133 | MP0001919_abnormal_reproductive_system | 0.74476129 |
| 134 | MP0002751_abnormal_autonomic_nervous | 0.73897279 |
| 135 | MP0005330_cardiomyopathy | 0.73710156 |
| 136 | MP0001661_extended_life_span | 0.73631295 |
| 137 | MP0010030_abnormal_orbit_morphology | 0.73153900 |
| 138 | MP0000613_abnormal_salivary_gland | 0.73062192 |
| 139 | MP0005389_reproductive_system_phenotype | 0.72621576 |
| 140 | MP0008873_increased_physiological_sensi | 0.72474402 |
| 141 | MP0002210_abnormal_sex_determination | 0.71057076 |
| 142 | MP0001485_abnormal_pinna_reflex | 0.70127643 |
| 143 | MP0000681_abnormal_thyroid_gland | 0.69754024 |
| 144 | MP0004808_abnormal_hematopoietic_stem | 0.69595405 |
| 145 | MP0005253_abnormal_eye_physiology | 0.69056650 |
| 146 | MP0003137_abnormal_impulse_conducting | 0.66594375 |
| 147 | MP0001968_abnormal_touch/_nociception | 0.65150201 |
| 148 | MP0006072_abnormal_retinal_apoptosis | 0.64371554 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.39296242 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.83762774 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.82229809 |
| 4 | Hepatocellular necrosis (HP:0001404) | 4.24059399 |
| 5 | Acute encephalopathy (HP:0006846) | 4.23514731 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.21310396 |
| 7 | Increased CSF lactate (HP:0002490) | 4.15674862 |
| 8 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.01761127 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.88938791 |
| 10 | Birth length less than 3rd percentile (HP:0003561) | 3.65428928 |
| 11 | Increased serum pyruvate (HP:0003542) | 3.60598272 |
| 12 | Abnormality of glycolysis (HP:0004366) | 3.60598272 |
| 13 | Abnormal number of erythroid precursors (HP:0012131) | 3.57638042 |
| 14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.57342064 |
| 15 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.57342064 |
| 16 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.55243075 |
| 17 | Hepatic necrosis (HP:0002605) | 3.51959652 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 3.51780976 |
| 19 | Renal Fanconi syndrome (HP:0001994) | 3.47998008 |
| 20 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.45074126 |
| 21 | Methylmalonic aciduria (HP:0012120) | 3.43879449 |
| 22 | Lipid accumulation in hepatocytes (HP:0006561) | 3.30633839 |
| 23 | Exertional dyspnea (HP:0002875) | 3.21229615 |
| 24 | Increased serum lactate (HP:0002151) | 3.18057296 |
| 25 | Cerebral hypomyelination (HP:0006808) | 3.11868504 |
| 26 | Reticulocytopenia (HP:0001896) | 3.11576615 |
| 27 | Exercise intolerance (HP:0003546) | 2.97185789 |
| 28 | Testicular atrophy (HP:0000029) | 2.95524360 |
| 29 | Lactic acidosis (HP:0003128) | 2.91505841 |
| 30 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.87923201 |
| 31 | Type I transferrin isoform profile (HP:0003642) | 2.86431844 |
| 32 | Respiratory failure (HP:0002878) | 2.85047897 |
| 33 | Microvesicular hepatic steatosis (HP:0001414) | 2.83953129 |
| 34 | Hypoplasia of the fovea (HP:0007750) | 2.83254439 |
| 35 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 2.83254439 |
| 36 | Breast hypoplasia (HP:0003187) | 2.82667265 |
| 37 | Petechiae (HP:0000967) | 2.80462001 |
| 38 | Aplastic anemia (HP:0001915) | 2.79241779 |
| 39 | Opisthotonus (HP:0002179) | 2.76927113 |
| 40 | Methylmalonic acidemia (HP:0002912) | 2.76846002 |
| 41 | Increased intramyocellular lipid droplets (HP:0012240) | 2.71424068 |
| 42 | Macrocytic anemia (HP:0001972) | 2.70847211 |
| 43 | Optic disc pallor (HP:0000543) | 2.70400485 |
| 44 | Respiratory difficulties (HP:0002880) | 2.67110940 |
| 45 | Spastic paraparesis (HP:0002313) | 2.67073355 |
| 46 | Cerebral edema (HP:0002181) | 2.66282050 |
| 47 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.63406991 |
| 48 | Dicarboxylic aciduria (HP:0003215) | 2.63406991 |
| 49 | Leukodystrophy (HP:0002415) | 2.61916698 |
| 50 | Pallor (HP:0000980) | 2.57352032 |
| 51 | Oral leukoplakia (HP:0002745) | 2.54949498 |
| 52 | Hypokinesia (HP:0002375) | 2.54420820 |
| 53 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.50802548 |
| 54 | Abnormality of alanine metabolism (HP:0010916) | 2.47392919 |
| 55 | Hyperalaninemia (HP:0003348) | 2.47392919 |
| 56 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.47392919 |
| 57 | Rough bone trabeculation (HP:0100670) | 2.43866429 |
| 58 | Poor head control (HP:0002421) | 2.42988451 |
| 59 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.42659530 |
| 60 | Abnormality of the labia minora (HP:0012880) | 2.41637592 |
| 61 | Abnormality of the anterior horn cell (HP:0006802) | 2.41623657 |
| 62 | Degeneration of anterior horn cells (HP:0002398) | 2.41623657 |
| 63 | Carpal bone hypoplasia (HP:0001498) | 2.29231123 |
| 64 | Abnormality of renal resorption (HP:0011038) | 2.28869601 |
| 65 | Abnormality of the fovea (HP:0000493) | 2.22362462 |
| 66 | Cleft eyelid (HP:0000625) | 2.21929064 |
| 67 | Lethargy (HP:0001254) | 2.20774943 |
| 68 | Tongue fasciculations (HP:0001308) | 2.17274782 |
| 69 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.16895644 |
| 70 | Ketoacidosis (HP:0001993) | 2.16108396 |
| 71 | Recurrent abscess formation (HP:0002722) | 2.15012968 |
| 72 | Progressive muscle weakness (HP:0003323) | 2.14793187 |
| 73 | Medial flaring of the eyebrow (HP:0010747) | 2.14675807 |
| 74 | Ragged-red muscle fibers (HP:0003200) | 2.13497969 |
| 75 | Reduced antithrombin III activity (HP:0001976) | 2.12044867 |
| 76 | Increased muscle lipid content (HP:0009058) | 2.10821333 |
| 77 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.10105864 |
| 78 | Pancreatic cysts (HP:0001737) | 2.09475907 |
| 79 | Irregular epiphyses (HP:0010582) | 2.09473021 |
| 80 | Abnormal hair whorl (HP:0010721) | 2.08737069 |
| 81 | Hyperthyroidism (HP:0000836) | 2.08269999 |
| 82 | Pancreatic fibrosis (HP:0100732) | 2.07913300 |
| 83 | Progressive microcephaly (HP:0000253) | 2.07861141 |
| 84 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.07803056 |
| 85 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.07803056 |
| 86 | Abnormal protein glycosylation (HP:0012346) | 2.07803056 |
| 87 | Abnormal glycosylation (HP:0012345) | 2.07803056 |
| 88 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.04436150 |
| 89 | Death in infancy (HP:0001522) | 2.00992790 |
| 90 | Amniotic constriction ring (HP:0009775) | 2.00341041 |
| 91 | Abnormality of placental membranes (HP:0011409) | 2.00341041 |
| 92 | Emotional lability (HP:0000712) | 1.99627081 |
| 93 | Microretrognathia (HP:0000308) | 1.97320906 |
| 94 | True hermaphroditism (HP:0010459) | 1.96369317 |
| 95 | CNS hypomyelination (HP:0003429) | 1.95112116 |
| 96 | Abnormal pupillary function (HP:0007686) | 1.94897241 |
| 97 | CNS demyelination (HP:0007305) | 1.94766338 |
| 98 | Cerebral palsy (HP:0100021) | 1.94323741 |
| 99 | Increased IgM level (HP:0003496) | 1.94072512 |
| 100 | Ketosis (HP:0001946) | 1.93018873 |
| 101 | Increased serum ferritin (HP:0003281) | 1.93007548 |
| 102 | Prolonged neonatal jaundice (HP:0006579) | 1.92252268 |
| 103 | Abnormal trabecular bone morphology (HP:0100671) | 1.90713928 |
| 104 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 1.90626143 |
| 105 | Pancytopenia (HP:0001876) | 1.90419627 |
| 106 | Type 2 muscle fiber atrophy (HP:0003554) | 1.90195173 |
| 107 | Truncus arteriosus (HP:0001660) | 1.89375630 |
| 108 | Nephrogenic diabetes insipidus (HP:0009806) | 1.89126716 |
| 109 | Poor suck (HP:0002033) | 1.88900693 |
| 110 | Abnormality of macrophages (HP:0004311) | 1.88075536 |
| 111 | Congenital primary aphakia (HP:0007707) | 1.87751287 |
| 112 | Myopathic facies (HP:0002058) | 1.87500496 |
| 113 | Postnatal microcephaly (HP:0005484) | 1.87203226 |
| 114 | Muscle fibrillation (HP:0010546) | 1.86026437 |
| 115 | Prostate neoplasm (HP:0100787) | 1.85726721 |
| 116 | Stenosis of the external auditory canal (HP:0000402) | 1.83314558 |
| 117 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.82723543 |
| 118 | Recurrent bacterial skin infections (HP:0005406) | 1.81588950 |
| 119 | Muscle fiber atrophy (HP:0100295) | 1.80700221 |
| 120 | Delusions (HP:0000746) | 1.79822948 |
| 121 | Congenital stationary night blindness (HP:0007642) | 1.78026518 |
| 122 | Hypothermia (HP:0002045) | 1.77292210 |
| 123 | Hypoplasia of the pons (HP:0012110) | 1.76808141 |
| 124 | Multiple enchondromatosis (HP:0005701) | 1.76722803 |
| 125 | Redundant skin (HP:0001582) | 1.75731325 |
| 126 | IgM deficiency (HP:0002850) | 1.75676520 |
| 127 | Paraparesis (HP:0002385) | 1.74751383 |
| 128 | Cellular immunodeficiency (HP:0005374) | 1.74100443 |
| 129 | Gait imbalance (HP:0002141) | 1.73819383 |
| 130 | Dysphonia (HP:0001618) | 1.72799437 |
| 131 | Trismus (HP:0000211) | 1.72278047 |
| 132 | Abnormality of iron homeostasis (HP:0011031) | 1.72159029 |
| 133 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.72096161 |
| 134 | Severe visual impairment (HP:0001141) | 1.71975770 |
| 135 | 11 pairs of ribs (HP:0000878) | 1.69780252 |
| 136 | Stomatitis (HP:0010280) | 1.69758171 |
| 137 | Patellar aplasia (HP:0006443) | 1.69313744 |
| 138 | Sensory axonal neuropathy (HP:0003390) | 1.68753122 |
| 139 | Metaphyseal dysplasia (HP:0100255) | 1.67741339 |
| 140 | Abnormality of magnesium homeostasis (HP:0004921) | 1.67722486 |
| 141 | Premature graying of hair (HP:0002216) | 1.67289925 |
| 142 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 1.67052962 |
| 143 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.66495545 |
| 144 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.65636988 |
| 145 | Secondary amenorrhea (HP:0000869) | 1.65489924 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.42886667 |
| 2 | BUB1 | 4.26221567 |
| 3 | NME2 | 3.31714329 |
| 4 | MAP3K12 | 3.28297367 |
| 5 | ARAF | 3.27682647 |
| 6 | STK16 | 3.13594315 |
| 7 | EIF2AK1 | 3.06651767 |
| 8 | WEE1 | 2.77654064 |
| 9 | EIF2AK3 | 2.70813001 |
| 10 | PIM2 | 2.60138621 |
| 11 | PBK | 2.36245887 |
| 12 | MST4 | 2.36100265 |
| 13 | PLK4 | 2.28182116 |
| 14 | TESK2 | 2.13543566 |
| 15 | NME1 | 1.96773408 |
| 16 | VRK1 | 1.95047663 |
| 17 | BRAF | 1.93015823 |
| 18 | ACVR1B | 1.86954499 |
| 19 | BRSK2 | 1.72739783 |
| 20 | SMG1 | 1.62125202 |
| 21 | SRPK1 | 1.58765860 |
| 22 | TLK1 | 1.48009967 |
| 23 | TSSK6 | 1.45073153 |
| 24 | IRAK4 | 1.42192937 |
| 25 | BCR | 1.38881141 |
| 26 | TNK2 | 1.37430561 |
| 27 | LIMK1 | 1.30948118 |
| 28 | CDC7 | 1.29523937 |
| 29 | NUAK1 | 1.21153879 |
| 30 | PRKD3 | 1.19842356 |
| 31 | MAP3K11 | 1.18817377 |
| 32 | STK4 | 1.17278629 |
| 33 | KDR | 1.15503322 |
| 34 | TXK | 1.12523159 |
| 35 | MYLK | 1.12514478 |
| 36 | PHKG2 | 1.11886208 |
| 37 | PHKG1 | 1.11886208 |
| 38 | BMPR1B | 1.11524527 |
| 39 | STK10 | 1.09721937 |
| 40 | SIK3 | 1.09536744 |
| 41 | BMPR2 | 1.08860389 |
| 42 | TESK1 | 1.05995690 |
| 43 | ABL2 | 1.04465125 |
| 44 | CDK19 | 1.03711238 |
| 45 | DYRK2 | 0.99460590 |
| 46 | MAP4K2 | 0.96470968 |
| 47 | PLK1 | 0.95981248 |
| 48 | AURKA | 0.95394878 |
| 49 | DYRK3 | 0.90889323 |
| 50 | MAP2K7 | 0.89576534 |
| 51 | MAPKAPK3 | 0.88799538 |
| 52 | CASK | 0.87026753 |
| 53 | ADRBK2 | 0.86650385 |
| 54 | EPHA2 | 0.84337645 |
| 55 | PLK3 | 0.84090722 |
| 56 | BRSK1 | 0.83793795 |
| 57 | ERN1 | 0.83411995 |
| 58 | RAF1 | 0.82039243 |
| 59 | LRRK2 | 0.80496862 |
| 60 | ZAK | 0.79918626 |
| 61 | PDK2 | 0.79163994 |
| 62 | EIF2AK2 | 0.79093379 |
| 63 | IRAK3 | 0.78992518 |
| 64 | CDK8 | 0.77233938 |
| 65 | IKBKB | 0.76236902 |
| 66 | RPS6KA4 | 0.76226175 |
| 67 | DAPK2 | 0.76042710 |
| 68 | RIPK4 | 0.75396471 |
| 69 | DAPK1 | 0.75371581 |
| 70 | TAOK2 | 0.73419171 |
| 71 | CSNK1G3 | 0.73398379 |
| 72 | MAPKAPK5 | 0.73075341 |
| 73 | TYK2 | 0.72848306 |
| 74 | CCNB1 | 0.71683026 |
| 75 | MAP3K14 | 0.70525399 |
| 76 | MAP2K3 | 0.70248450 |
| 77 | PLK2 | 0.69270215 |
| 78 | TBK1 | 0.69197321 |
| 79 | ALK | 0.69132568 |
| 80 | AKT3 | 0.68807916 |
| 81 | FES | 0.68704864 |
| 82 | BLK | 0.68389783 |
| 83 | MAP3K3 | 0.67967628 |
| 84 | RPS6KB2 | 0.67879719 |
| 85 | AURKB | 0.63660749 |
| 86 | CSNK2A1 | 0.62811043 |
| 87 | AKT2 | 0.61688848 |
| 88 | CSNK1G1 | 0.61152261 |
| 89 | MKNK1 | 0.61039977 |
| 90 | PAK1 | 0.60387392 |
| 91 | STK24 | 0.59958524 |
| 92 | RPS6KA5 | 0.59131548 |
| 93 | PASK | 0.58152583 |
| 94 | TAOK1 | 0.57450280 |
| 95 | TEC | 0.56271727 |
| 96 | GRK1 | 0.56214946 |
| 97 | MAP4K1 | 0.55187365 |
| 98 | MAP3K8 | 0.54978194 |
| 99 | SCYL2 | 0.54635177 |
| 100 | IKBKE | 0.54301749 |
| 101 | MAP2K2 | 0.53434189 |
| 102 | CDK9 | 0.53238180 |
| 103 | PAK6 | 0.52637366 |
| 104 | PIM1 | 0.52065296 |
| 105 | GRK7 | 0.50885616 |
| 106 | CAMKK2 | 0.50080549 |
| 107 | SYK | 0.49619453 |
| 108 | MARK3 | 0.49349072 |
| 109 | ZAP70 | 0.48841673 |
| 110 | PAK4 | 0.48000782 |
| 111 | CSNK1G2 | 0.47990503 |
| 112 | GRK5 | 0.47509751 |
| 113 | BCKDK | 0.45785080 |
| 114 | ILK | 0.45043969 |
| 115 | YES1 | 0.44977923 |
| 116 | MUSK | 0.44446783 |
| 117 | CSNK2A2 | 0.44430992 |
| 118 | LYN | 0.44292577 |
| 119 | CDK7 | 0.44170229 |
| 120 | OXSR1 | 0.43695352 |
| 121 | MKNK2 | 0.40635738 |
| 122 | LMTK2 | 0.40050361 |
| 123 | CHEK2 | 0.39538108 |
| 124 | TTK | 0.38924477 |
| 125 | PRKCD | 0.38021500 |
| 126 | HIPK2 | 0.37647889 |
| 127 | JAK3 | 0.36528627 |
| 128 | GRK6 | 0.35291411 |
| 129 | PRKCI | 0.34665859 |
| 130 | ADRBK1 | 0.33736055 |
| 131 | CLK1 | 0.33727510 |
| 132 | DAPK3 | 0.31821807 |
| 133 | MOS | 0.31633367 |
| 134 | MAP2K6 | 0.31201554 |
| 135 | ATR | 0.31157650 |
| 136 | KIT | 0.30859875 |
| 137 | PTK2 | 0.30048446 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.30456381 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 4.44652740 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 4.02781040 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.72087328 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.18400063 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.89583613 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.72342003 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.55583579 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.53178749 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.51982273 |
| 11 | Huntingtons disease_Homo sapiens_hsa05016 | 2.45826857 |
| 12 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.24668611 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 2.17368149 |
| 14 | Homologous recombination_Homo sapiens_hsa03440 | 2.13516022 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 2.06636191 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.03113625 |
| 17 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.88707159 |
| 18 | Base excision repair_Homo sapiens_hsa03410 | 1.83341875 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.81193039 |
| 20 | RNA transport_Homo sapiens_hsa03013 | 1.69292092 |
| 21 | Purine metabolism_Homo sapiens_hsa00230 | 1.47670803 |
| 22 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.39828951 |
| 23 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.36761794 |
| 24 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.36321698 |
| 25 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.28003981 |
| 26 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.25028234 |
| 27 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.24740801 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 1.22219859 |
| 29 | Cell cycle_Homo sapiens_hsa04110 | 1.18507222 |
| 30 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.18437009 |
| 31 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.17094272 |
| 32 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.14598910 |
| 33 | Phototransduction_Homo sapiens_hsa04744 | 1.13613250 |
| 34 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.13502781 |
| 35 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.10557449 |
| 36 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.10176237 |
| 37 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.07734126 |
| 38 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.06040761 |
| 39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.05474118 |
| 40 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.05417757 |
| 41 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.03977351 |
| 42 | Allograft rejection_Homo sapiens_hsa05330 | 1.02982968 |
| 43 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.01818093 |
| 44 | Carbon metabolism_Homo sapiens_hsa01200 | 1.01329220 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.99812897 |
| 46 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.98849345 |
| 47 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.95918829 |
| 48 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.93030541 |
| 49 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.86876844 |
| 50 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.83441441 |
| 51 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.80604864 |
| 52 | Legionellosis_Homo sapiens_hsa05134 | 0.79658887 |
| 53 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.78477404 |
| 54 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.74942472 |
| 55 | Peroxisome_Homo sapiens_hsa04146 | 0.72433390 |
| 56 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.72127228 |
| 57 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.71698824 |
| 58 | Phagosome_Homo sapiens_hsa04145 | 0.68866183 |
| 59 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.67597590 |
| 60 | Asthma_Homo sapiens_hsa05310 | 0.67445187 |
| 61 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.67042862 |
| 62 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.66008993 |
| 63 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.65164616 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.64955430 |
| 65 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59533331 |
| 66 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.59212788 |
| 67 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.58800182 |
| 68 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.57715601 |
| 69 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.57620230 |
| 70 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.57104144 |
| 71 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.57022283 |
| 72 | Shigellosis_Homo sapiens_hsa05131 | 0.56669914 |
| 73 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.55063973 |
| 74 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.54736491 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.53719617 |
| 76 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.53603993 |
| 77 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.51913969 |
| 78 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.51667035 |
| 79 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.51501067 |
| 80 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.50470724 |
| 81 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.50433532 |
| 82 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.50300720 |
| 83 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.50211678 |
| 84 | Sulfur relay system_Homo sapiens_hsa04122 | 0.47701324 |
| 85 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.47180493 |
| 86 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.45612871 |
| 87 | Measles_Homo sapiens_hsa05162 | 0.44250941 |
| 88 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.43989497 |
| 89 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.43689605 |
| 90 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.42720115 |
| 91 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.40864568 |
| 92 | Leishmaniasis_Homo sapiens_hsa05140 | 0.40001253 |
| 93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.39428625 |
| 94 | Other glycan degradation_Homo sapiens_hsa00511 | 0.38344881 |
| 95 | Pertussis_Homo sapiens_hsa05133 | 0.35648730 |
| 96 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.35591166 |
| 97 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.35400092 |
| 98 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.35222256 |
| 99 | Salmonella infection_Homo sapiens_hsa05132 | 0.35138722 |
| 100 | Galactose metabolism_Homo sapiens_hsa00052 | 0.33947624 |
| 101 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.33892375 |
| 102 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.33026278 |
| 103 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.31572715 |
| 104 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.31465114 |
| 105 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.30930875 |
| 106 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.30869668 |
| 107 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.29763121 |
| 108 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.29323802 |
| 109 | * mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.28891077 |
| 110 | Apoptosis_Homo sapiens_hsa04210 | 0.28847983 |
| 111 | Influenza A_Homo sapiens_hsa05164 | 0.28817937 |
| 112 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.28295650 |
| 113 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.26235344 |
| 114 | Tuberculosis_Homo sapiens_hsa05152 | 0.26097230 |
| 115 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.25682933 |
| 116 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.25423716 |
| 117 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.24025257 |
| 118 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.23649783 |
| 119 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.23421033 |
| 120 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.20981059 |
| 121 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.20506069 |
| 122 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.20342931 |
| 123 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.20229903 |
| 124 | Mineral absorption_Homo sapiens_hsa04978 | 0.19717545 |
| 125 | Malaria_Homo sapiens_hsa05144 | 0.19711499 |
| 126 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.19221343 |
| 127 | Lysosome_Homo sapiens_hsa04142 | 0.18007097 |
| 128 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.17426133 |
| 129 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.15734828 |
| 130 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.13730892 |
| 131 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.13034923 |
| 132 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.12199093 |
| 133 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.09016361 |
| 134 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.08524082 |
| 135 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.05628310 |
| 136 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.04905925 |

