ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	8.51296582
2	multicellular organism reproduction (GO:0032504)	7.56405431
3	histone lysine demethylation (GO:0070076)	7.18609751
4	synaptonemal complex organization (GO:0070193)	6.99901711
5	histone demethylation (GO:0016577)	6.79781811
6	regulation of RIG-I signaling pathway (GO:0039535)	6.78703435
7	synaptonemal complex assembly (GO:0007130)	6.75835882
8	regulation of acrosome reaction (GO:0060046)	6.70400463
9	regulation of exit from mitosis (GO:0007096)	6.67296133
10	positive regulation of meiosis (GO:0045836)	6.27117520
11	protein dealkylation (GO:0008214)	6.12636155
12	protein demethylation (GO:0006482)	6.12636155
13	positive regulation of catecholamine secretion (GO:0033605)	6.08089346
14	positive regulation of meiotic cell cycle (GO:0051446)	6.05124444
15	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	5.94482653
16	gonadal mesoderm development (GO:0007506)	5.90246523
17	negative regulation of Ras GTPase activity (GO:0034261)	5.78261818
18	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	5.54623504
19	N-terminal protein amino acid acetylation (GO:0006474)	5.53943764
20	positive regulation of uterine smooth muscle contraction (GO:0070474)	5.49437288
21	male meiosis (GO:0007140)	5.27741956
22	single fertilization (GO:0007338)	5.20522115
23	male meiosis I (GO:0007141)	5.12441377
24	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.10955898
25	acrosome reaction (GO:0007340)	5.08551992
26	reproduction (GO:0000003)	5.04169372
27	regulation of female receptivity (GO:0045924)	4.97841271
28	binding of sperm to zona pellucida (GO:0007339)	4.74832185
29	chromosome organization involved in meiosis (GO:0070192)	4.45495678
30	female mating behavior (GO:0060180)	4.25486679
31	protein K48-linked deubiquitination (GO:0071108)	4.18434707
32	regulation of uterine smooth muscle contraction (GO:0070472)	4.17238735
33	meiosis I (GO:0007127)	4.08105951
34	protein kinase C signaling (GO:0070528)	4.05568506
35	fertilization (GO:0009566)	3.98374030
36	response to UV-C (GO:0010225)	3.89173443
37	protein K6-linked ubiquitination (GO:0085020)	3.86385485
38	piRNA metabolic process (GO:0034587)	3.81993484
39	centriole replication (GO:0007099)	3.80855607
40	aggressive behavior (GO:0002118)	3.80593667
41	regulation of meiosis (GO:0040020)	3.76797527
42	drinking behavior (GO:0042756)	3.71601544
43	sperm-egg recognition (GO:0035036)	3.69590720
44	regulation of penile erection (GO:0060405)	3.67443783
45	epithelial cilium movement (GO:0003351)	3.66554441
46	positive regulation of digestive system process (GO:0060456)	3.63859146
47	negative regulation of reproductive process (GO:2000242)	3.57314503
48	regulation of female gonad development (GO:2000194)	3.57226671
49	positive regulation of humoral immune response (GO:0002922)	3.51214659
50	cilium movement (GO:0003341)	3.45086692
51	intestinal epithelial cell development (GO:0060576)	3.42576586
52	calcium ion-dependent exocytosis (GO:0017156)	3.42127086
53	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.40273445
54	meiotic cell cycle (GO:0051321)	3.38510320
55	regulation of ruffle assembly (GO:1900027)	3.36714838
56	regulation of mRNA splicing, via spliceosome (GO:0048024)	3.32731516
57	meiotic cell cycle process (GO:1903046)	3.32327254
58	sleep (GO:0030431)	3.32269460
59	positive regulation of prostaglandin secretion (GO:0032308)	3.31958495
60	negative regulation of digestive system process (GO:0060457)	3.29511115
61	regulation of helicase activity (GO:0051095)	3.29132690
62	spermatid development (GO:0007286)	3.27390663
63	positive regulation of histone H3-K4 methylation (GO:0051571)	3.26273465
64	protein K63-linked deubiquitination (GO:0070536)	3.25237249
65	demethylation (GO:0070988)	3.22263030
66	retinal cone cell development (GO:0046549)	3.22139398
67	poly(A)+ mRNA export from nucleus (GO:0016973)	3.21661349
68	citrulline biosynthetic process (GO:0019240)	3.19788517
69	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.17205979
70	regulation of defense response to virus by host (GO:0050691)	3.15785719
71	regulation of meiotic cell cycle (GO:0051445)	3.10779380
72	positive regulation of reproductive process (GO:2000243)	3.09974296
73	hyperosmotic salinity response (GO:0042538)	3.09391994
74	cell-cell recognition (GO:0009988)	3.00859614
75	striated muscle atrophy (GO:0014891)	3.00314439
76	regulation of receptor binding (GO:1900120)	2.90937400
77	ventricular system development (GO:0021591)	2.88058579
78	regulation of mRNA processing (GO:0050684)	2.85106753
79	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.84358798
80	maturation of SSU-rRNA (GO:0030490)	2.84059832
81	regulation of DNA endoreduplication (GO:0032875)	2.83687548
82	regulation of histone H3-K9 methylation (GO:0051570)	2.83503128
83	trivalent inorganic anion homeostasis (GO:0072506)	2.81594662
84	phosphate ion homeostasis (GO:0055062)	2.81594662
85	exocrine pancreas development (GO:0031017)	2.81195912
86	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.80435730
87	meiotic nuclear division (GO:0007126)	2.80282565
88	RNA localization (GO:0006403)	2.78336472
89	centrosome duplication (GO:0051298)	2.76218211
90	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	2.73469420
91	maternal behavior (GO:0042711)	2.73444216
92	N-terminal protein amino acid modification (GO:0031365)	2.71855764
93	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.71563729
94	postsynaptic membrane organization (GO:0001941)	2.69234068
95	germ cell development (GO:0007281)	2.68450481
96	transcription from mitochondrial promoter (GO:0006390)	2.67317505
97	microtubule severing (GO:0051013)	2.67145609
98	histone H3-K9 demethylation (GO:0033169)	18.2613966
99	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	13.8831819
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	11.6198053

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	8.40799448
2	EZH2_22144423_ChIP-Seq_EOC_Human	5.84062864
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.68988131
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.79679804
5	VDR_22108803_ChIP-Seq_LS180_Human	3.73910568
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.43592644
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.94119059
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.89370130
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81478823
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74512459
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.40712877
12	AUTS2_25519132_ChIP-Seq_293T-REX_Human	2.19971993
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19254107
14	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.12027042
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.05950425
16	TOP2B_26459242_ChIP-Seq_MCF-7_Human	2.03312461
17	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.98919287
18	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.98244325
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.87499275
20	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.87276941
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84093317
22	TCF4_23295773_ChIP-Seq_U87_Human	1.81309208
23	AR_21909140_ChIP-Seq_LNCAP_Human	1.77819174
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.77143103
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.74856463
26	RXR_22108803_ChIP-Seq_LS180_Human	1.71614588
27	STAT3_23295773_ChIP-Seq_U87_Human	1.63820394
28	CBP_21632823_ChIP-Seq_H3396_Human	1.61653388
29	P300_19829295_ChIP-Seq_ESCs_Human	1.61073463
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.60636122
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.58810846
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.58401671
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56093811
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52756823
35	AR_25329375_ChIP-Seq_VCAP_Human	1.52015646
36	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.49056177
37	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.48115465
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.47538567
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46175407
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43663317
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.42493147
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.42454350
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41172166
44	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.40308760
45	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.39460652
46	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.38965974
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38733697
48	NCOR_22424771_ChIP-Seq_293T_Human	1.38657700
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.36655424
50	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.35196014
51	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.34321786
52	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.34301652
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.34161293
54	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.32212295
55	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.32088659
56	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.31466892
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31383878
58	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.30855407
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30486363
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27942932
61	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.27561015
62	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.26871765
63	ZNF274_21170338_ChIP-Seq_K562_Hela	1.25020766
64	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.24324028
65	GF1_26923725_Chip-Seq_HPCs_Mouse	1.23290990
66	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22899166
67	GATA3_26560356_Chip-Seq_TH1_Human	1.21243822
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.18896003
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16838065
70	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15278613
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13793397
72	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.11806015
73	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.11806015
74	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.11806015
75	SMRT_27268052_Chip-Seq_Bcells_Human	1.11704414
76	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.09917471
77	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08351208
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07721735
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.05177282
80	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.05064598
81	TP63_23658742_ChIP-Seq_EP156T_Human	1.04139458
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03874905
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.03637173
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.03002269
85	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.02355342
86	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01201779
87	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.01065130
88	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.97274010
89	RAC3_21632823_ChIP-Seq_H3396_Human	0.96245009
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.93084641
91	TP53_22573176_ChIP-Seq_HFKS_Human	0.92734692
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.92584513
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92584513
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.91645900
95	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.91266248
96	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.91012075
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.90759433
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89285980
99	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.88199752
100	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.88149511

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.01789195
2	MP0003283_abnormal_digestive_organ	4.86048291
3	MP0003950_abnormal_plasma_membrane	4.28272889
4	MP0009379_abnormal_foot_pigmentation	3.64876271
5	MP0005410_abnormal_fertilization	3.60725702
6	MP0002160_abnormal_reproductive_system	3.60433739
7	MP0003136_yellow_coat_color	3.60314745
8	MP0000678_abnormal_parathyroid_gland	3.54432434
9	MP0003693_abnormal_embryo_hatching	3.10147879
10	MP0009840_abnormal_foam_cell	2.92892921
11	MP0005360_urolithiasis	2.87639472
12	MP0000427_abnormal_hair_cycle	2.79989150
13	MP0001502_abnormal_circadian_rhythm	2.74519395
14	MP0001929_abnormal_gametogenesis	2.67638634
15	MP0006276_abnormal_autonomic_nervous	2.61052714
16	MP0008058_abnormal_DNA_repair	2.43655231
17	MP0002210_abnormal_sex_determination	2.28743385
18	MP0001664_abnormal_digestion	2.10815359
19	MP0003718_maternal_effect	1.98257858
20	MP0003699_abnormal_female_reproductive	1.97373213
21	MP0005220_abnormal_exocrine_pancreas	1.87443119
22	MP0003183_abnormal_peptide_metabolism	1.84016144
23	MP0005647_abnormal_sex_gland	1.82679587
24	MP0003119_abnormal_digestive_system	1.82350963
25	MP0005389_reproductive_system_phenotype	1.79465740
26	MP0003868_abnormal_feces_composition	1.77377611
27	MP0002751_abnormal_autonomic_nervous	1.75532597
28	MP0001666_abnormal_nutrient_absorption	1.74085300
29	MP0000653_abnormal_sex_gland	1.64358027
30	MP0008877_abnormal_DNA_methylation	1.62666016
31	MP0000049_abnormal_middle_ear	1.62030298
32	MP0003866_abnormal_defecation	1.61921099
33	MP0003698_abnormal_male_reproductive	1.59722183
34	MP0010094_abnormal_chromosome_stability	1.51134774
35	MP0005646_abnormal_pituitary_gland	1.42934401
36	MP0003890_abnormal_embryonic-extraembry	1.38667655
37	MP0002161_abnormal_fertility/fecundity	1.37315668
38	MP0006072_abnormal_retinal_apoptosis	1.35476459
39	MP0001119_abnormal_female_reproductive	1.30812387
40	MP0001145_abnormal_male_reproductive	1.30669040
41	MP0010307_abnormal_tumor_latency	1.20947656
42	MP0002277_abnormal_respiratory_mucosa	1.20168216
43	MP0003077_abnormal_cell_cycle	1.17375600
44	MP0004043_abnormal_pH_regulation	1.17145644
45	MP0003936_abnormal_reproductive_system	1.12546788
46	MP0003938_abnormal_ear_development	1.12434484
47	MP0002090_abnormal_vision	1.11713689
48	MP0002102_abnormal_ear_morphology	1.10397049
49	MP0004233_abnormal_muscle_weight	1.03615231
50	MP0000372_irregular_coat_pigmentation	1.02407842
51	MP0000470_abnormal_stomach_morphology	1.00783126
52	MP0004742_abnormal_vestibular_system	0.96918599
53	MP0000230_abnormal_systemic_arterial	0.96316092
54	MP0000631_abnormal_neuroendocrine_gland	0.94699476
55	MP0005551_abnormal_eye_electrophysiolog	0.94491476
56	MP0002272_abnormal_nervous_system	0.91909738
57	MP0001440_abnormal_grooming_behavior	0.90629288
58	MP0001501_abnormal_sleep_pattern	0.88940174
59	MP0002127_abnormal_cardiovascular_syste	0.88166760
60	MP0005394_taste/olfaction_phenotype	0.87594541
61	MP0005499_abnormal_olfactory_system	0.87594541
62	MP0005076_abnormal_cell_differentiation	0.86599878
63	MP0002229_neurodegeneration	0.85207805
64	MP0005253_abnormal_eye_physiology	0.84710477
65	MP0001730_embryonic_growth_arrest	0.82998684
66	MP0003879_abnormal_hair_cell	0.82530583
67	MP0002184_abnormal_innervation	0.80814017
68	MP0000534_abnormal_ureter_morphology	0.80618756
69	MP0005171_absent_coat_pigmentation	0.80517594
70	MP0001286_abnormal_eye_development	0.80109600
71	MP0000778_abnormal_nervous_system	0.79853460
72	MP0002396_abnormal_hematopoietic_system	0.77218562
73	MP0000462_abnormal_digestive_system	0.77004172
74	MP0002163_abnormal_gland_morphology	0.73370878
75	MP0000428_abnormal_craniofacial_morphol	0.69215923
76	MP0004381_abnormal_hair_follicle	0.68878425
77	MP0010368_abnormal_lymphatic_system	0.66683234
78	MP0000647_abnormal_sebaceous_gland	0.66089245
79	MP0000350_abnormal_cell_proliferation	0.65512043
80	MP0001881_abnormal_mammary_gland	0.64104745
81	MP0005334_abnormal_fat_pad	0.61340180
82	MP0005423_abnormal_somatic_nervous	0.61299585
83	MP0005197_abnormal_uvea_morphology	0.61251779
84	MP0002095_abnormal_skin_pigmentation	0.60855107
85	MP0003111_abnormal_nucleus_morphology	0.60024956
86	MP0003121_genomic_imprinting	0.58900741
87	MP0002249_abnormal_larynx_morphology	0.58750326
88	MP0003880_abnormal_central_pattern	0.57353809
89	MP0001963_abnormal_hearing_physiology	0.57188151
90	MP0009745_abnormal_behavioral_response	0.57098771
91	MP0008789_abnormal_olfactory_epithelium	0.55137377
92	MP0005623_abnormal_meninges_morphology	0.55030120
93	MP0004270_analgesia	0.54812230
94	MP0002693_abnormal_pancreas_physiology	0.54763533
95	MP0009765_abnormal_xenobiotic_induced	0.54751989
96	MP0002234_abnormal_pharynx_morphology	0.54193392
97	MP0001944_abnormal_pancreas_morphology	0.53885391
98	MP0001986_abnormal_taste_sensitivity	0.51969761
99	MP0002067_abnormal_sensory_capabilities	0.51409478
100	MP0004859_abnormal_synaptic_plasticity	0.50480809

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	8.08430169
2	Median cleft lip (HP:0000161)	5.46062011
3	Short tibia (HP:0005736)	4.89835444
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.76716202
5	Microglossia (HP:0000171)	4.71960526
6	Atonic seizures (HP:0010819)	4.44228213
7	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.03869415
8	Oligodactyly (hands) (HP:0001180)	4.00129702
9	Abnormal number of incisors (HP:0011064)	3.90544155
10	Abnormal auditory evoked potentials (HP:0006958)	3.85946542
11	Facial cleft (HP:0002006)	3.76694377
12	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.70715493
13	Congenital sensorineural hearing impairment (HP:0008527)	3.69349565
14	Hyperphosphatemia (HP:0002905)	3.47456947
15	Abnormality of the nasal septum (HP:0000419)	3.47298911
16	Metaphyseal dysplasia (HP:0100255)	3.44320855
17	Male infertility (HP:0003251)	3.41525600
18	Tetany (HP:0001281)	3.40481434
19	Tetraparesis (HP:0002273)	3.32933884
20	Adrenal hypoplasia (HP:0000835)	3.18189186
21	Impulsivity (HP:0100710)	3.16473152
22	Amelogenesis imperfecta (HP:0000705)	3.11503918
23	Neurofibrillary tangles (HP:0002185)	3.07001099
24	Abnormality of calcium-phosphate metabolism (HP:0100530)	3.06591351
25	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.90964383
26	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.90964383
27	Abnormal ciliary motility (HP:0012262)	2.82551645
28	Short chin (HP:0000331)	2.81127470
29	Pancreatic fibrosis (HP:0100732)	2.75118176
30	Maternal diabetes (HP:0009800)	2.73979756
31	Abdominal situs inversus (HP:0003363)	2.73919011
32	Abnormality of abdominal situs (HP:0011620)	2.73919011
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.68520447
34	Submucous cleft hard palate (HP:0000176)	2.64010379
35	Loss of speech (HP:0002371)	2.62829003
36	Rhinitis (HP:0012384)	2.59994879
37	Abnormality of lateral ventricle (HP:0030047)	2.58530804
38	Abnormal respiratory motile cilium physiology (HP:0012261)	2.56452009
39	Abnormality of the corticospinal tract (HP:0002492)	2.56377777
40	Autoimmune thrombocytopenia (HP:0001973)	2.56372027
41	Anterior segment dysgenesis (HP:0007700)	2.55132452
42	Oligodactyly (HP:0012165)	2.54567583
43	Abnormality of chromosome stability (HP:0003220)	2.46142881
44	Abnormality of dental color (HP:0011073)	2.42451005
45	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.39816143
46	Absent/shortened dynein arms (HP:0200106)	2.39816143
47	Microretrognathia (HP:0000308)	2.37441461
48	Type I diabetes mellitus (HP:0100651)	2.34909355
49	Glossoptosis (HP:0000162)	2.33505214
50	Ectopic kidney (HP:0000086)	2.30973001
51	Anhidrosis (HP:0000970)	2.29481896
52	Absent phalangeal crease (HP:0006109)	2.28967915
53	Abnormality of the incisor (HP:0000676)	2.22085080
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.20576856
55	Myokymia (HP:0002411)	2.18896898
56	Abnormality of the labia minora (HP:0012880)	2.17147634
57	Chromsome breakage (HP:0040012)	2.14170820
58	Abnormal pancreas size (HP:0012094)	2.13920106
59	Exertional dyspnea (HP:0002875)	2.11842617
60	Pili torti (HP:0003777)	2.04117746
61	Hypoplasia of the iris (HP:0007676)	2.04013899
62	Bony spicule pigmentary retinopathy (HP:0007737)	2.03519684
63	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.00301204
64	Facial hemangioma (HP:0000329)	2.00030610
65	Fair hair (HP:0002286)	1.99445626
66	Genital tract atresia (HP:0001827)	1.98217473
67	Infertility (HP:0000789)	1.98063263
68	Prostate neoplasm (HP:0100787)	1.97785037
69	Azoospermia (HP:0000027)	1.97679502
70	Hypophosphatemic rickets (HP:0004912)	1.97163618
71	Sensory axonal neuropathy (HP:0003390)	1.95833630
72	Optic nerve hypoplasia (HP:0000609)	1.94793947
73	Reticulocytopenia (HP:0001896)	1.93995765
74	Increased hepatocellular lipid droplets (HP:0006565)	1.92202476
75	Renal Fanconi syndrome (HP:0001994)	1.91984334
76	Disproportionate short-trunk short stature (HP:0003521)	1.90848071
77	Hypoplasia of the radius (HP:0002984)	1.90566515
78	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88849211
79	Supernumerary spleens (HP:0009799)	1.87705641
80	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.85504233
81	Papillary thyroid carcinoma (HP:0002895)	1.85193999
82	Multiple enchondromatosis (HP:0005701)	1.84434984
83	Autoimmune hemolytic anemia (HP:0001890)	1.83812087
84	Spinal muscular atrophy (HP:0007269)	1.81388542
85	Abnormality of the frontal sinuses (HP:0002687)	1.81105593
86	Partial agenesis of the corpus callosum (HP:0001338)	1.79933810
87	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.78253606
88	Hypoplasia of the fovea (HP:0007750)	1.78253606
89	Meckel diverticulum (HP:0002245)	1.78236140
90	Abnormality of the ileum (HP:0001549)	1.77627313
91	Abnormal finger flexion creases (HP:0006143)	1.76719299
92	Short middle phalanx of the 5th finger (HP:0004220)	1.76382819
93	Absent thumb (HP:0009777)	1.76088658
94	Apathy (HP:0000741)	1.73066774
95	Chronic bronchitis (HP:0004469)	1.72316575
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72056762
97	Osteomalacia (HP:0002749)	1.70757241
98	Abnormality of the preputium (HP:0100587)	1.69687527
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.68540071
100	Short thumb (HP:0009778)	1.68457191

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.83371072
2	CDK12	4.09445888
3	TNIK	3.84116340
4	PLK4	3.29911142
5	TAOK3	2.95933287
6	CDK19	2.90060631
7	AURKA	2.78675400
8	ZAK	2.70866177
9	TLK1	2.60229978
10	VRK1	2.47769479
11	LATS2	2.36791018
12	STK39	2.31926159
13	CDC7	1.93662385
14	ICK	1.81183172
15	SRPK1	1.75990885
16	TESK2	1.63097986
17	ACVR1B	1.59452466
18	NLK	1.59190850
19	TTK	1.54395248
20	TEC	1.52413321
21	BMPR1B	1.52235648
22	EPHA4	1.39850897
23	STK38L	1.38696779
24	MAP2K3	1.38493550
25	LATS1	1.38156559
26	PKN1	1.37123273
27	ARAF	1.36540509
28	WNK1	1.28886485
29	MAP3K3	1.28404425
30	STK24	1.27155808
31	AURKB	1.23097307
32	CHEK2	1.21587690
33	NUAK1	1.16215208
34	PBK	1.08250728
35	PLK1	1.08005597
36	PIM2	1.05745669
37	OXSR1	1.02179848
38	PLK2	1.00433624
39	BRAF	0.95007482
40	SGK2	0.94142631
41	MELK	0.90776941
42	PIK3CA	0.87923245
43	MARK2	0.87770913
44	TRIM28	0.85743736
45	PINK1	0.85264152
46	GRK7	0.80406619
47	STK3	0.78663924
48	MARK3	0.78148566
49	MAPK13	0.72533906
50	VRK2	0.71657302
51	MOS	0.70446081
52	CHEK1	0.66004568
53	RPS6KA5	0.64778361
54	NEK6	0.64482805
55	RAF1	0.60306340
56	WNK4	0.59385492
57	CSNK1E	0.55549893
58	CAMK4	0.55501348
59	GRK1	0.55346055
60	CDK7	0.55137377
61	MAPKAPK2	0.53962394
62	PIK3CG	0.52174346
63	GRK5	0.51595917
64	SGK223	0.49449642
65	SGK494	0.49449642
66	PIM1	0.49079040
67	JAK3	0.47855593
68	PDK2	0.46944890
69	BUB1	0.44761925
70	CDK2	0.42462993
71	CAMK1	0.42029807
72	CSNK1D	0.41966255
73	PRKACA	0.41436933
74	PAK1	0.39943352
75	ATM	0.38387111
76	PRKD1	0.37289375
77	ILK	0.36410151
78	PLK3	0.36245818
79	FRK	0.35108699
80	CDK5	0.35037824
81	MAP3K5	0.33755737
82	STK4	0.33493374
83	MAP3K9	0.33235962
84	NTRK2	0.33036671
85	PRKACB	0.32945765
86	CDK1	0.32925862
87	SGK3	0.30645761
88	MAPK12	0.30333172
89	CDK9	0.30162473
90	MTOR	0.29730001
91	IRAK1	0.29683103
92	TNK2	0.28080223
93	EIF2AK3	0.26930391
94	PRKG1	0.26298727
95	CSNK1G1	0.25651637
96	PDK1	0.25504147
97	AKT2	0.25393995
98	CSNK2A2	0.25296166
99	CSNK2A1	0.24810251
100	TBK1	0.24697055

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	7.23309906
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.48471182
3	Basal transcription factors_Homo sapiens_hsa03022	3.02238210
4	Ribosome_Homo sapiens_hsa03010	2.93240071
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.88048517
6	Mismatch repair_Homo sapiens_hsa03430	2.80445313
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.63799090
8	Bile secretion_Homo sapiens_hsa04976	2.56313506
9	Homologous recombination_Homo sapiens_hsa03440	2.26163845
10	Sulfur metabolism_Homo sapiens_hsa00920	2.14729308
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.98206757
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.91191321
13	Oocyte meiosis_Homo sapiens_hsa04114	1.82971454
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.80573325
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.79177344
16	Olfactory transduction_Homo sapiens_hsa04740	1.77087981
17	mRNA surveillance pathway_Homo sapiens_hsa03015	1.74891630
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.68440883
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.61930198
20	RNA transport_Homo sapiens_hsa03013	1.60595986
21	RNA polymerase_Homo sapiens_hsa03020	1.60451177
22	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.59992415
23	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.52858924
24	Retinol metabolism_Homo sapiens_hsa00830	1.51303819
25	Phototransduction_Homo sapiens_hsa04744	1.47421015
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35676873
27	Alcoholism_Homo sapiens_hsa05034	1.28273751
28	RNA degradation_Homo sapiens_hsa03018	1.27804002
29	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.25544580
30	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.23687802
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15695254
32	Insulin secretion_Homo sapiens_hsa04911	1.14228072
33	Circadian rhythm_Homo sapiens_hsa04710	1.04231338
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98294837
35	Cell cycle_Homo sapiens_hsa04110	0.94945202
36	Serotonergic synapse_Homo sapiens_hsa04726	0.94938682
37	Lysine degradation_Homo sapiens_hsa00310	0.89119004
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87572635
39	Taste transduction_Homo sapiens_hsa04742	0.84015005
40	DNA replication_Homo sapiens_hsa03030	0.82344303
41	GABAergic synapse_Homo sapiens_hsa04727	0.80636257
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80073750
43	Gap junction_Homo sapiens_hsa04540	0.75181897
44	Spliceosome_Homo sapiens_hsa03040	0.74079321
45	p53 signaling pathway_Homo sapiens_hsa04115	0.73704882
46	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.72203044
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.72140695
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70094734
49	Purine metabolism_Homo sapiens_hsa00230	0.69224263
50	Nicotine addiction_Homo sapiens_hsa05033	0.67575350
51	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.66692942
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.65981160
53	cAMP signaling pathway_Homo sapiens_hsa04024	0.65769250
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64992860
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64442722
56	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.63186961
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.62563942
58	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.62303959
59	Cholinergic synapse_Homo sapiens_hsa04725	0.61448369
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58636556
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.53486470
62	Herpes simplex infection_Homo sapiens_hsa05168	0.52782241
63	Cocaine addiction_Homo sapiens_hsa05030	0.52073715
64	ABC transporters_Homo sapiens_hsa02010	0.51792074
65	Regulation of autophagy_Homo sapiens_hsa04140	0.51647181
66	Morphine addiction_Homo sapiens_hsa05032	0.50924400
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48038021
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.46245565
69	Huntingtons disease_Homo sapiens_hsa05016	0.44241584
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.43156998
71	Tight junction_Homo sapiens_hsa04530	0.37656578
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.37228393
73	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.36967806
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36578178
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35116450
76	Dopaminergic synapse_Homo sapiens_hsa04728	0.34726464
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.34278215
78	Apoptosis_Homo sapiens_hsa04210	0.33459459
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32486896
80	Histidine metabolism_Homo sapiens_hsa00340	0.32424041
81	Colorectal cancer_Homo sapiens_hsa05210	0.32365271
82	Folate biosynthesis_Homo sapiens_hsa00790	0.32163255
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.31535276
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28980758
85	Viral carcinogenesis_Homo sapiens_hsa05203	0.28462007
86	PPAR signaling pathway_Homo sapiens_hsa03320	0.28408459
87	Circadian entrainment_Homo sapiens_hsa04713	0.28280235
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.27883257
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.27546967
90	Pancreatic secretion_Homo sapiens_hsa04972	0.27163563
91	Protein digestion and absorption_Homo sapiens_hsa04974	0.26515319
92	Salivary secretion_Homo sapiens_hsa04970	0.26282809
93	One carbon pool by folate_Homo sapiens_hsa00670	0.26218249
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.24644486
95	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.24093292
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.24052394
97	Legionellosis_Homo sapiens_hsa05134	0.23734402
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.22583535
99	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.21229226
100	Amphetamine addiction_Homo sapiens_hsa05031	0.20947200

SSU72P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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