SSUH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.27564230
2fusion of sperm to egg plasma membrane (GO:0007342)7.30940036
3acrosome reaction (GO:0007340)7.29964388
4axonemal dynein complex assembly (GO:0070286)6.28667252
5cilium or flagellum-dependent cell motility (GO:0001539)5.90864667
6spermatid development (GO:0007286)5.52189268
7phosphatidylethanolamine biosynthetic process (GO:0006646)5.50759241
8plasma membrane fusion (GO:0045026)5.47369163
9protein polyglutamylation (GO:0018095)5.34464207
10sperm capacitation (GO:0048240)5.17390932
11sperm-egg recognition (GO:0035036)5.09012665
12response to pheromone (GO:0019236)5.08316949
13phosphatidylethanolamine metabolic process (GO:0046337)5.04086765
14multicellular organism reproduction (GO:0032504)5.03305348
15intestinal cholesterol absorption (GO:0030299)5.03102861
16very-low-density lipoprotein particle assembly (GO:0034379)4.85403425
17epithelial cilium movement (GO:0003351)4.82116892
18motile cilium assembly (GO:0044458)4.81539972
19plasma lipoprotein particle assembly (GO:0034377)4.80907805
20binding of sperm to zona pellucida (GO:0007339)4.68477379
21low-density lipoprotein particle remodeling (GO:0034374)4.57444781
22reproduction (GO:0000003)4.47993629
23regulation of cilium movement (GO:0003352)4.45808948
24rRNA methylation (GO:0031167)4.37789016
25cilium movement (GO:0003341)4.35897662
26microtubule depolymerization (GO:0007019)4.28009994
27cell-cell recognition (GO:0009988)4.27135208
28indole-containing compound catabolic process (GO:0042436)4.25471294
29indolalkylamine catabolic process (GO:0046218)4.25471294
30tryptophan catabolic process (GO:0006569)4.25471294
31protein-lipid complex assembly (GO:0065005)4.05333101
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.99962812
33regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.97578948
34protein-lipid complex remodeling (GO:0034368)3.91725207
35macromolecular complex remodeling (GO:0034367)3.91725207
36plasma lipoprotein particle remodeling (GO:0034369)3.91725207
37spermatogenesis (GO:0007283)3.89831600
38establishment of protein localization to Golgi (GO:0072600)3.89747686
39male gamete generation (GO:0048232)3.88819106
40protein targeting to Golgi (GO:0000042)3.88601315
41high-density lipoprotein particle remodeling (GO:0034375)3.87930855
42peptidyl-glutamic acid modification (GO:0018200)3.87641587
43microtubule severing (GO:0051013)3.84211874
44spermatid nucleus differentiation (GO:0007289)3.81034713
45chromosome condensation (GO:0030261)3.79497718
46rRNA modification (GO:0000154)3.78581925
47seminiferous tubule development (GO:0072520)3.75751808
48organic cation transport (GO:0015695)3.74967441
49regulation of cholesterol esterification (GO:0010872)3.74563351
50microtubule polymerization or depolymerization (GO:0031109)3.70152216
51sexual reproduction (GO:0019953)3.69438132
52plasma lipoprotein particle organization (GO:0071827)3.68418019
53aromatic amino acid family catabolic process (GO:0009074)3.68128774
54reverse cholesterol transport (GO:0043691)3.67973299
55negative regulation of fibrinolysis (GO:0051918)3.65838164
56gamete generation (GO:0007276)3.62470492
57calcium ion-dependent exocytosis (GO:0017156)3.62295572
58cholesterol efflux (GO:0033344)3.61643317
59DNA packaging (GO:0006323)3.59992226
60single fertilization (GO:0007338)3.58551170
61cellular ketone body metabolic process (GO:0046950)3.58235505
62indolalkylamine metabolic process (GO:0006586)3.57049099
63retrograde transport, vesicle recycling within Golgi (GO:0000301)3.50828105
64diacylglycerol metabolic process (GO:0046339)3.50375584
65nephron epithelium morphogenesis (GO:0072088)3.46445915
66nephron tubule morphogenesis (GO:0072078)3.46445915
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.44587547
68intestinal absorption (GO:0050892)3.42917626
69NAD biosynthetic process (GO:0009435)3.42771233
70cell wall macromolecule catabolic process (GO:0016998)3.40331823
71amine catabolic process (GO:0009310)3.40198588
72cellular biogenic amine catabolic process (GO:0042402)3.40198588
73regulation of protein activation cascade (GO:2000257)3.38620221
74peptidyl-glutamic acid carboxylation (GO:0017187)3.36827656
75protein carboxylation (GO:0018214)3.36827656
76regulation of complement activation (GO:0030449)3.35047023
77axoneme assembly (GO:0035082)3.34020794
78protein-lipid complex subunit organization (GO:0071825)3.34013016
79centriole assembly (GO:0098534)3.32995682
80coenzyme catabolic process (GO:0009109)3.30347143
81cellular zinc ion homeostasis (GO:0006882)3.30133738
82cell wall macromolecule metabolic process (GO:0044036)3.28605404
83amine biosynthetic process (GO:0009309)3.27817530
84fertilization (GO:0009566)3.27331773
85centriole replication (GO:0007099)3.25004332
86negative regulation of sodium ion transport (GO:0010766)3.21676931
87tryptophan metabolic process (GO:0006568)3.21032921
88germ cell development (GO:0007281)3.20382504
89protein localization to Golgi apparatus (GO:0034067)3.16308573
90polyamine biosynthetic process (GO:0006596)3.15741460
91plasma lipoprotein particle clearance (GO:0034381)3.15549297
92single strand break repair (GO:0000012)3.12692624
93transepithelial transport (GO:0070633)3.09087880
94cellular biogenic amine biosynthetic process (GO:0042401)3.07800492
95ketone body metabolic process (GO:1902224)3.06915828
96C4-dicarboxylate transport (GO:0015740)3.04509843
97kynurenine metabolic process (GO:0070189)3.04336446
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.03618438
99L-phenylalanine catabolic process (GO:0006559)3.03618438
100male meiosis (GO:0007140)3.01973059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.41933876
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14930508
3IGF1R_20145208_ChIP-Seq_DFB_Human2.39457097
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39059072
5VDR_22108803_ChIP-Seq_LS180_Human2.36267989
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29389499
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17000570
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.09568172
9CBP_20019798_ChIP-Seq_JUKART_Human2.07302116
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.07302116
11ER_23166858_ChIP-Seq_MCF-7_Human2.02568003
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02530786
13FUS_26573619_Chip-Seq_HEK293_Human1.91144631
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90327746
15POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.90327746
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90050763
17GBX2_23144817_ChIP-Seq_PC3_Human1.86050561
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82829174
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82813799
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.80346006
21AR_21572438_ChIP-Seq_LNCaP_Human1.73808241
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73397642
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72395619
24MYC_19829295_ChIP-Seq_ESCs_Human1.71116807
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70961473
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.70814047
27KLF5_20875108_ChIP-Seq_MESCs_Mouse1.70601552
28RAC3_21632823_ChIP-Seq_H3396_Human1.69978223
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68690864
30P300_19829295_ChIP-Seq_ESCs_Human1.67653328
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66101770
32ERA_21632823_ChIP-Seq_H3396_Human1.62116065
33NANOG_20526341_ChIP-Seq_ESCs_Human1.61777986
34EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.61309400
35EZH2_22144423_ChIP-Seq_EOC_Human1.57799526
36SOX2_19829295_ChIP-Seq_ESCs_Human1.57332508
37NANOG_19829295_ChIP-Seq_ESCs_Human1.57332508
38OCT4_20526341_ChIP-Seq_ESCs_Human1.54267611
39CEBPB_22108803_ChIP-Seq_LS180_Human1.51151932
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49799822
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.47055844
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.47029239
43HNF4A_19822575_ChIP-Seq_HepG2_Human1.47010669
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.46154478
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45414735
46TAF15_26573619_Chip-Seq_HEK293_Human1.43684005
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.40448512
48STAT3_23295773_ChIP-Seq_U87_Human1.39130377
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36844240
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36561529
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35732724
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.35297465
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.33964815
54AR_25329375_ChIP-Seq_VCAP_Human1.33806199
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.33588014
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30339833
57RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.29703457
58HOXB7_26014856_ChIP-Seq_BT474_Human1.28180320
59TAF2_19829295_ChIP-Seq_ESCs_Human1.27999019
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.27689540
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27550877
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.27550877
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.25399612
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.25356387
65CBX2_22325352_ChIP-Seq_293T-Rex_Human1.25167042
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.24456061
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24317031
68ETV1_20927104_ChIP-Seq_GIST48_Human1.22826560
69RUNX2_22187159_ChIP-Seq_PCA_Human1.21685944
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20186917
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20131886
72NCOR_22424771_ChIP-Seq_293T_Human1.19800023
73CDX2_22108803_ChIP-Seq_LS180_Human1.19443287
74GATA4_25053715_ChIP-Seq_YYC3_Human1.19436836
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18139918
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.15549843
77RBPJ_21746931_ChIP-Seq_IB4_Human1.15145505
78SMAD4_21799915_ChIP-Seq_A2780_Human1.13709869
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13450463
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12837257
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11358900
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11035907
83TCF4_22108803_ChIP-Seq_LS180_Human1.10719761
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09399516
85TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09013270
86FOXH1_21741376_ChIP-Seq_EPCs_Human1.08095828
87IRF1_19129219_ChIP-ChIP_H3396_Human1.07307878
88SMAD4_21741376_ChIP-Seq_HESCs_Human1.06461035
89HNFA_21074721_ChIP-Seq_CACO-2_Human1.06103981
90ERG_20517297_ChIP-Seq_VCAP_Human1.05866103
91AR_20517297_ChIP-Seq_VCAP_Human1.05442929
92TCF4_23295773_ChIP-Seq_U87_Human1.05129597
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04993461
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.04729544
95PHF8_20622854_ChIP-Seq_HELA_Human1.04428990
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04204242
97FOXH1_21741376_ChIP-Seq_ESCs_Human1.02971192
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02793852
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01971350
100PHF8_20622853_ChIP-Seq_HELA_Human1.01310083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.43478712
2MP0005360_urolithiasis4.70195169
3MP0008875_abnormal_xenobiotic_pharmacok3.39041437
4MP0003195_calcinosis3.32130989
5MP0002139_abnormal_hepatobiliary_system3.25980578
6MP0003122_maternal_imprinting3.25101680
7MP0005365_abnormal_bile_salt3.22138742
8MP0003698_abnormal_male_reproductive2.94945455
9MP0005670_abnormal_white_adipose2.77905289
10MP0005377_hearing/vestibular/ear_phenot2.65090596
11MP0003878_abnormal_ear_physiology2.65090596
12MP0010329_abnormal_lipoprotein_level2.62578341
13MP0001666_abnormal_nutrient_absorption2.57068116
14MP0001929_abnormal_gametogenesis2.56542839
15MP0005085_abnormal_gallbladder_physiolo2.56526840
16MP0002132_abnormal_respiratory_system2.54793077
17MP0005451_abnormal_body_composition2.23785204
18MP0005167_abnormal_blood-brain_barrier2.21264258
19MP0003718_maternal_effect2.20877417
20MP0005551_abnormal_eye_electrophysiolog1.76117182
21MP0002161_abnormal_fertility/fecundity1.65779758
22MP0003252_abnormal_bile_duct1.61468853
23MP0008004_abnormal_stomach_pH1.57289548
24MP0002160_abnormal_reproductive_system1.49296789
25MP0009697_abnormal_copulation1.47996597
26MP0005636_abnormal_mineral_homeostasis1.41954650
27MP0001529_abnormal_vocalization1.41579372
28MP0001764_abnormal_homeostasis1.38555344
29MP0000566_synostosis1.35018808
30MP0005332_abnormal_amino_acid1.34027931
31MP0000653_abnormal_sex_gland1.28171524
32MP0000678_abnormal_parathyroid_gland1.27341395
33MP0002102_abnormal_ear_morphology1.27308121
34MP0002138_abnormal_hepatobiliary_system1.26568282
35MP0001984_abnormal_olfaction1.25670590
36MP0003315_abnormal_perineum_morphology1.25600409
37MP0003646_muscle_fatigue1.22686808
38MP0002210_abnormal_sex_determination1.21355487
39MP0005253_abnormal_eye_physiology1.18458177
40MP0001145_abnormal_male_reproductive1.17531414
41MP0002118_abnormal_lipid_homeostasis1.15976710
42MP0005084_abnormal_gallbladder_morpholo1.13315630
43MP0005379_endocrine/exocrine_gland_phen1.12389660
44MP0005408_hypopigmentation1.12349440
45MP0006054_spinal_hemorrhage1.12343422
46MP0002938_white_spotting1.10002390
47MP0005646_abnormal_pituitary_gland1.07955577
48MP0003011_delayed_dark_adaptation1.07927944
49MP0004043_abnormal_pH_regulation1.06496459
50MP0005647_abnormal_sex_gland1.04259578
51MP0005395_other_phenotype0.98304483
52MP0001968_abnormal_touch/_nociception0.97774783
53MP0005389_reproductive_system_phenotype0.95806208
54MP0003950_abnormal_plasma_membrane0.94547277
55MP0002282_abnormal_trachea_morphology0.93270799
56MP0009780_abnormal_chondrocyte_physiolo0.92715301
57MP0003172_abnormal_lysosome_physiology0.92282274
58MP0009046_muscle_twitch0.90310775
59MP0001765_abnormal_ion_homeostasis0.89490250
60MP0000609_abnormal_liver_physiology0.88435787
61MP0006292_abnormal_olfactory_placode0.83953125
62MP0003656_abnormal_erythrocyte_physiolo0.83657636
63MP0001486_abnormal_startle_reflex0.82332200
64MP0005394_taste/olfaction_phenotype0.81964297
65MP0005499_abnormal_olfactory_system0.81964297
66MP0001485_abnormal_pinna_reflex0.81110459
67MP0010368_abnormal_lymphatic_system0.80681551
68MP0008789_abnormal_olfactory_epithelium0.79569471
69MP0003121_genomic_imprinting0.78862641
70MP0002229_neurodegeneration0.78328679
71MP0008872_abnormal_physiological_respon0.77342129
72MP0001270_distended_abdomen0.77168999
73MP0000639_abnormal_adrenal_gland0.76655436
74MP0003868_abnormal_feces_composition0.75159328
75MP0004019_abnormal_vitamin_homeostasis0.74939002
76MP0005464_abnormal_platelet_physiology0.74560746
77MP0004742_abnormal_vestibular_system0.74384090
78MP0009643_abnormal_urine_homeostasis0.73073485
79MP0001501_abnormal_sleep_pattern0.73066919
80MP0008877_abnormal_DNA_methylation0.71510974
81MP0003633_abnormal_nervous_system0.71070107
82MP0003136_yellow_coat_color0.70319041
83MP0003879_abnormal_hair_cell0.69346641
84MP0005058_abnormal_lysosome_morphology0.69086070
85MP0002557_abnormal_social/conspecific_i0.69018707
86MP0001963_abnormal_hearing_physiology0.66968651
87MP0005391_vision/eye_phenotype0.62561996
88MP0005319_abnormal_enzyme/_coenzyme0.61498634
89MP0001324_abnormal_eye_pigmentation0.60475529
90MP0001664_abnormal_digestion0.60459303
91MP0003183_abnormal_peptide_metabolism0.59972672
92MP0009642_abnormal_blood_homeostasis0.59790549
93MP0005310_abnormal_salivary_gland0.59772976
94MP0005448_abnormal_energy_balance0.59684520
95MP0009115_abnormal_fat_cell0.59647707
96MP0003631_nervous_system_phenotype0.59640349
97MP0001905_abnormal_dopamine_level0.56259991
98MP0006072_abnormal_retinal_apoptosis0.55974475
99MP0000230_abnormal_systemic_arterial0.55946659
100MP0008995_early_reproductive_senescence0.55907767

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.42796957
2Absent/shortened dynein arms (HP:0200106)5.42796957
3Deep venous thrombosis (HP:0002625)4.82242468
4Abnormal ciliary motility (HP:0012262)4.49695814
5Abnormal respiratory motile cilium physiology (HP:0012261)4.47824614
6Abnormal respiratory motile cilium morphology (HP:0005938)4.45047201
7Abnormal respiratory epithelium morphology (HP:0012253)4.45047201
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.43396580
9Severe visual impairment (HP:0001141)3.68320660
10Prolonged partial thromboplastin time (HP:0003645)3.65576449
11Hypobetalipoproteinemia (HP:0003563)3.52403326
12Chronic hepatic failure (HP:0100626)3.43386454
13Facial shape deformation (HP:0011334)3.28991045
14Potter facies (HP:0002009)3.28991045
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.22920560
16Attenuation of retinal blood vessels (HP:0007843)3.20741439
17Spontaneous abortion (HP:0005268)3.11439349
18Acanthocytosis (HP:0001927)3.08754724
19Hypophosphatemic rickets (HP:0004912)3.07837855
20Joint hemorrhage (HP:0005261)3.04538366
21Tubulointerstitial nephritis (HP:0001970)3.03154769
22Rhinitis (HP:0012384)2.85550228
23Broad alveolar ridges (HP:0000187)2.83219518
24True hermaphroditism (HP:0010459)2.80948671
25Hypolipoproteinemia (HP:0010981)2.73131163
26Widely patent fontanelles and sutures (HP:0004492)2.72707200
27Pancreatic cysts (HP:0001737)2.69025655
28Infertility (HP:0000789)2.68035917
29Generalized aminoaciduria (HP:0002909)2.66263765
30Small epiphyses (HP:0010585)2.64430886
31Abnormality of macular pigmentation (HP:0008002)2.63285600
32Pancreatic fibrosis (HP:0100732)2.60896933
33Epiphyseal dysplasia (HP:0002656)2.60639911
34Supernumerary spleens (HP:0009799)2.57478111
35Nephronophthisis (HP:0000090)2.56256461
36Absent epiphyses (HP:0010577)2.54408505
37Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.54408505
38Occipital encephalocele (HP:0002085)2.49389275
39Bony spicule pigmentary retinopathy (HP:0007737)2.45787751
40Pancreatic islet-cell hyperplasia (HP:0004510)2.41858076
41Recurrent corneal erosions (HP:0000495)2.41558262
42Abnormal rod and cone electroretinograms (HP:0008323)2.39366680
43Hypercholesterolemia (HP:0003124)2.35109317
44Azoospermia (HP:0000027)2.34294908
45Cystic liver disease (HP:0006706)2.33256296
46Pigmentary retinal degeneration (HP:0001146)2.32854827
47Xanthomatosis (HP:0000991)2.30110311
48Chronic bronchitis (HP:0004469)2.29857142
49Abnormality of the nasal septum (HP:0000419)2.26701049
50Complement deficiency (HP:0004431)2.26053871
51Hypothermia (HP:0002045)2.24646635
52Abnormal urine output (HP:0012590)2.23364662
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22157650
54Gonadal dysgenesis (HP:0000133)2.21026111
55Abnormality of the pubic bones (HP:0003172)2.18888080
56Hypoalphalipoproteinemia (HP:0003233)2.15175022
57Menorrhagia (HP:0000132)2.12760797
58Male pseudohermaphroditism (HP:0000037)2.11797264
59Enlarged kidneys (HP:0000105)2.10697751
60Abnormal spermatogenesis (HP:0008669)2.09975277
61Portal hypertension (HP:0001409)2.09556066
62Hyperkalemia (HP:0002153)2.08569212
63Bronchiectasis (HP:0002110)2.08502106
64Enlarged epiphyses (HP:0010580)2.07809515
65Poikilocytosis (HP:0004447)2.06667184
66Type II lissencephaly (HP:0007260)2.05140505
67Abnormality of the renal medulla (HP:0100957)2.04359772
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03481608
69Abnormality of the hepatic vasculature (HP:0006707)2.01882468
70Abnormality of the costochondral junction (HP:0000919)1.99613121
71Male infertility (HP:0003251)1.99528661
72Abnormality of urine glucose concentration (HP:0011016)1.97859848
73Glycosuria (HP:0003076)1.97859848
74Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97271726
75Glomerulonephritis (HP:0000099)1.95911177
76Abnormality of the common coagulation pathway (HP:0010990)1.95680894
77Tubulointerstitial abnormality (HP:0001969)1.94173472
78Intrahepatic cholestasis (HP:0001406)1.93794477
79Decreased central vision (HP:0007663)1.91889733
80Rickets (HP:0002748)1.89420379
81Hyperglycinuria (HP:0003108)1.88694937
82Hyperglycinemia (HP:0002154)1.86850717
83Nasal polyposis (HP:0100582)1.82313667
84Hemorrhage of the eye (HP:0011885)1.81599392
85Metaphyseal irregularity (HP:0003025)1.79213187
86Abnormality of endocrine pancreas physiology (HP:0012093)1.78782693
87Abnormality of the pancreatic islet cells (HP:0006476)1.78782693
88Epidermoid cyst (HP:0200040)1.77966137
89Abnormality of renal excretion (HP:0011036)1.77932004
90Abnormality of dental color (HP:0011073)1.77519153
91Irregular epiphyses (HP:0010582)1.77214664
92Sclerocornea (HP:0000647)1.77106618
93Abnormality of the vitreous humor (HP:0004327)1.76838613
94Osteomalacia (HP:0002749)1.76128197
95Fat malabsorption (HP:0002630)1.75993073
96Abnormality of serine family amino acid metabolism (HP:0010894)1.75965829
97Abnormality of glycine metabolism (HP:0010895)1.75965829
98Polydipsia (HP:0001959)1.74776004
99Abnormal drinking behavior (HP:0030082)1.74776004
100Pendular nystagmus (HP:0012043)1.74459638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.73533323
2INSRR4.14380250
3FRK4.05459733
4PINK13.62011484
5DDR23.35817111
6MAP4K23.23670733
7WNK42.99121957
8FGFR32.25209386
9BMPR1B2.20356539
10PLK22.19623629
11ACVR1B2.10276497
12FGFR41.91993453
13BRD41.83836307
14STK38L1.72900016
15ZAK1.72761290
16LATS11.72707846
17ADRBK21.68224129
18TYRO31.54846760
19AKT31.54839912
20GRK11.49988080
21MAPK151.46784556
22STK381.31965023
23FGFR21.31907207
24MAP3K41.27313055
25WNK11.24136047
26PDK11.23265255
27MAP2K71.21751608
28CSNK1A1L1.20088619
29NEK21.19156982
30PDPK11.16300161
31DYRK1B1.15042325
32STK391.14004166
33BCKDK1.13764618
34PTK2B1.10804895
35MUSK1.08967334
36CSNK1G31.06320322
37PRKAA21.02422651
38MARK31.02316584
39PIK3CG0.99055338
40WNK30.95141940
41NUAK10.92797046
42TESK10.92646246
43PIK3CA0.88747366
44EPHA40.88206434
45CSNK1G10.86091666
46TLK10.84394105
47MAPKAPK30.81518840
48MATK0.79107114
49PNCK0.75583016
50CDK70.75122413
51CSNK1G20.73863604
52PRKG20.72655195
53TRIM280.71087657
54BCR0.69245978
55PIM20.67088923
56MST1R0.66929644
57PRKG10.64378637
58MAPK130.64178779
59MAPK110.60440286
60RPS6KA50.59912635
61EIF2AK10.58945242
62SGK2230.56916909
63SGK4940.56916909
64CDK120.56584165
65FER0.54380268
66PRKD30.54344886
67PRKAA10.54204913
68FGFR10.50330767
69MAPKAPK50.49778271
70FGR0.48781388
71TIE10.45209621
72RPS6KB10.44850548
73CAMK1G0.43388406
74PRKCQ0.43033611
75MYLK0.41836659
76FLT30.41640343
77PRKCG0.39739109
78CCNB10.38269034
79ERBB20.38067569
80PKN10.38029206
81MET0.37121441
82DYRK20.37032426
83SIK20.34222958
84CDK80.33495188
85CSNK1A10.33463025
86OXSR10.32479616
87RPS6KA10.32249537
88OBSCN0.31880920
89BRSK20.31405399
90PRKCE0.31167600
91LMTK20.30826033
92ICK0.30266347
93SYK0.29763509
94DYRK30.29526096
95NME10.29080562
96NTRK30.28680675
97MAPK10.28661119
98TAOK30.28123174
99CDK30.28066663
100CSNK1E0.28002244

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.66693538
2Caffeine metabolism_Homo sapiens_hsa002323.29329245
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.24590186
4Complement and coagulation cascades_Homo sapiens_hsa046102.86612609
5Butanoate metabolism_Homo sapiens_hsa006502.79074668
6Fat digestion and absorption_Homo sapiens_hsa049752.77023900
7Fatty acid degradation_Homo sapiens_hsa000712.38757900
8Fatty acid metabolism_Homo sapiens_hsa012122.15207702
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.09988217
10Vitamin digestion and absorption_Homo sapiens_hsa049772.03762088
11Chemical carcinogenesis_Homo sapiens_hsa052042.01508695
12Nitrogen metabolism_Homo sapiens_hsa009101.99377790
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91718753
14PPAR signaling pathway_Homo sapiens_hsa033201.91703171
15Propanoate metabolism_Homo sapiens_hsa006401.91011550
16Tryptophan metabolism_Homo sapiens_hsa003801.89494581
17Steroid biosynthesis_Homo sapiens_hsa001001.86579186
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.86082710
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81324632
20Histidine metabolism_Homo sapiens_hsa003401.81221631
21Olfactory transduction_Homo sapiens_hsa047401.79674019
22ABC transporters_Homo sapiens_hsa020101.79555662
23Phenylalanine metabolism_Homo sapiens_hsa003601.75540502
24Arginine biosynthesis_Homo sapiens_hsa002201.74342947
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64746417
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61580435
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.60960455
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.57614916
29Retinol metabolism_Homo sapiens_hsa008301.56109215
30Arginine and proline metabolism_Homo sapiens_hsa003301.53503070
31Peroxisome_Homo sapiens_hsa041461.50807163
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49173864
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45537336
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44208175
35Starch and sucrose metabolism_Homo sapiens_hsa005001.40623432
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38815250
37Glycerolipid metabolism_Homo sapiens_hsa005611.27913425
38Tyrosine metabolism_Homo sapiens_hsa003501.23185102
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20297973
40Renin-angiotensin system_Homo sapiens_hsa046141.17170320
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16857682
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15309559
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.14845363
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14741685
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.12778789
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.10738358
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09619959
48Phototransduction_Homo sapiens_hsa047441.08873367
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08528295
50beta-Alanine metabolism_Homo sapiens_hsa004101.07264548
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.05042703
52Linoleic acid metabolism_Homo sapiens_hsa005911.01437272
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97198844
54Taste transduction_Homo sapiens_hsa047420.95105436
55Staphylococcus aureus infection_Homo sapiens_hsa051500.93220131
56Glutathione metabolism_Homo sapiens_hsa004800.91017450
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76929726
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76485508
59Bile secretion_Homo sapiens_hsa049760.75547888
60Fatty acid elongation_Homo sapiens_hsa000620.73524187
61Metabolic pathways_Homo sapiens_hsa011000.72329891
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.71504396
63N-Glycan biosynthesis_Homo sapiens_hsa005100.70536731
64Sphingolipid metabolism_Homo sapiens_hsa006000.70195076
65Pyruvate metabolism_Homo sapiens_hsa006200.69371114
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64795538
67Ether lipid metabolism_Homo sapiens_hsa005650.64723538
68Mineral absorption_Homo sapiens_hsa049780.63489739
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57742064
70Arachidonic acid metabolism_Homo sapiens_hsa005900.54311475
71Sulfur relay system_Homo sapiens_hsa041220.54058513
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53150977
73Fanconi anemia pathway_Homo sapiens_hsa034600.48815825
74Asthma_Homo sapiens_hsa053100.46487538
75Selenocompound metabolism_Homo sapiens_hsa004500.45915035
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44739592
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40968130
78Allograft rejection_Homo sapiens_hsa053300.40904043
79Systemic lupus erythematosus_Homo sapiens_hsa053220.40813552
80Purine metabolism_Homo sapiens_hsa002300.40002433
81Type I diabetes mellitus_Homo sapiens_hsa049400.38514813
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38019653
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34787937
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.31991639
85Other glycan degradation_Homo sapiens_hsa005110.30761236
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.30163543
87Nicotine addiction_Homo sapiens_hsa050330.29622211
88Protein digestion and absorption_Homo sapiens_hsa049740.29423125
89Basal transcription factors_Homo sapiens_hsa030220.26535808
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26264558
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24901240
92Autoimmune thyroid disease_Homo sapiens_hsa053200.24641418
93Biosynthesis of amino acids_Homo sapiens_hsa012300.23036785
94RNA transport_Homo sapiens_hsa030130.22530895
95Salivary secretion_Homo sapiens_hsa049700.21201446
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.20948341
97Fructose and mannose metabolism_Homo sapiens_hsa000510.18925254
98Dorso-ventral axis formation_Homo sapiens_hsa043200.18175751
99Thyroid hormone synthesis_Homo sapiens_hsa049180.11949781
100Calcium signaling pathway_Homo sapiens_hsa040200.10667294

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