SSX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.86088090
2nuclear pore organization (GO:0006999)6.16126961
3pore complex assembly (GO:0046931)5.37132787
4DNA replication checkpoint (GO:0000076)5.32313907
5regulation of histone H3-K4 methylation (GO:0051569)5.03476229
6diterpenoid biosynthetic process (GO:0016102)5.00989283
7synapsis (GO:0007129)4.95776815
8regulation of histone H3-K27 methylation (GO:0061085)4.82740172
9regulation of translational fidelity (GO:0006450)4.57703538
10DNA topological change (GO:0006265)4.52512177
11mitotic sister chromatid segregation (GO:0000070)4.44930517
12terpenoid biosynthetic process (GO:0016114)4.43710449
13intra-S DNA damage checkpoint (GO:0031573)4.43044430
14sister chromatid segregation (GO:0000819)4.38385372
15meiotic chromosome segregation (GO:0045132)4.34901962
16positive regulation of histone H3-K4 methylation (GO:0051571)4.25034927
17protoporphyrinogen IX metabolic process (GO:0046501)4.24900576
18DNA unwinding involved in DNA replication (GO:0006268)4.18599505
19resolution of meiotic recombination intermediates (GO:0000712)4.13221908
20negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.13150440
21DNA methylation involved in gamete generation (GO:0043046)4.03654102
22DNA replication initiation (GO:0006270)4.02514205
23purine nucleobase biosynthetic process (GO:0009113)4.01908892
24homocysteine metabolic process (GO:0050667)4.00840896
25mitotic nuclear envelope disassembly (GO:0007077)3.86419560
26folic acid-containing compound biosynthetic process (GO:0009396)3.85832413
27gas transport (GO:0015669)3.73286898
28Peyers patch development (GO:0048541)3.72615578
29mucosal-associated lymphoid tissue development (GO:0048537)3.72615578
30nucleobase biosynthetic process (GO:0046112)3.71872488
31oxidative phosphorylation (GO:0006119)3.70615164
32vitamin A metabolic process (GO:0006776)3.64582577
33regulation of histone methylation (GO:0031060)3.63606186
34tetrahydrofolate metabolic process (GO:0046653)3.63131919
35regulation of RNA export from nucleus (GO:0046831)3.60530305
36regulation of retinoic acid receptor signaling pathway (GO:0048385)3.56253137
37detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.54400371
38microtubule depolymerization (GO:0007019)3.54364950
39tRNA aminoacylation for protein translation (GO:0006418)3.53284064
40membrane disassembly (GO:0030397)3.51493050
41nuclear envelope disassembly (GO:0051081)3.51493050
42oxygen transport (GO:0015671)3.50458982
43sensory perception of smell (GO:0007608)3.50403821
44regulation of gene expression by genetic imprinting (GO:0006349)3.50079594
45IMP biosynthetic process (GO:0006188)3.49909639
46positive regulation of histone methylation (GO:0031062)3.46159452
47protoporphyrinogen IX biosynthetic process (GO:0006782)3.43685515
48amino acid activation (GO:0043038)3.43439282
49tRNA aminoacylation (GO:0043039)3.43439282
50protein-cofactor linkage (GO:0018065)3.39711268
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38865586
52DNA strand elongation involved in DNA replication (GO:0006271)3.35890509
53kinetochore organization (GO:0051383)3.33634888
54formation of translation preinitiation complex (GO:0001731)3.33476075
55definitive hemopoiesis (GO:0060216)3.33191482
56DNA strand elongation (GO:0022616)3.25448391
57chromosome segregation (GO:0007059)3.16693051
58mitotic recombination (GO:0006312)3.14290173
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13009122
60erythrocyte maturation (GO:0043249)3.09741884
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.07510590
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07510590
63regulation of translational elongation (GO:0006448)3.06353791
64regulation of centriole replication (GO:0046599)3.06328606
65DNA catabolic process, exonucleolytic (GO:0000738)3.02496316
66iron ion import (GO:0097286)3.02422895
67telomere maintenance via semi-conservative replication (GO:0032201)3.01731052
68ribosome biogenesis (GO:0042254)2.99007969
69kinetochore assembly (GO:0051382)2.96000340
70telomere maintenance via recombination (GO:0000722)2.95764146
71mismatch repair (GO:0006298)2.94582063
72phosphorelay signal transduction system (GO:0000160)2.93172742
73chromosome organization involved in meiosis (GO:0070192)2.89266872
74microtubule polymerization or depolymerization (GO:0031109)2.89237466
75IMP metabolic process (GO:0046040)2.87944917
76creatine metabolic process (GO:0006600)2.87924188
77pseudouridine synthesis (GO:0001522)2.87842862
78response to vitamin A (GO:0033189)2.83378116
79double-strand break repair via homologous recombination (GO:0000724)2.83036062
80male meiosis I (GO:0007141)2.82193325
81maturation of 5.8S rRNA (GO:0000460)2.81895320
82ribosomal large subunit biogenesis (GO:0042273)2.79892358
83succinate metabolic process (GO:0006105)2.77265881
84recombinational repair (GO:0000725)2.77092305
85oxaloacetate metabolic process (GO:0006107)2.74329526
86telomere maintenance via telomere lengthening (GO:0010833)2.69909640
87regulation of histone H3-K9 methylation (GO:0051570)2.69846758
88isoprenoid biosynthetic process (GO:0008299)2.68734825
89regulation of mitotic spindle organization (GO:0060236)2.66789047
90reciprocal DNA recombination (GO:0035825)2.66424306
91reciprocal meiotic recombination (GO:0007131)2.66424306
92regulation of centrosome cycle (GO:0046605)2.65929942
93valine metabolic process (GO:0006573)2.65699868
94regulation of nucleobase-containing compound transport (GO:0032239)2.65669889
95nucleotide-excision repair, DNA gap filling (GO:0006297)2.64391054
96sulfur amino acid biosynthetic process (GO:0000097)2.63803568
97one-carbon compound transport (GO:0019755)2.62761156
98folic acid-containing compound metabolic process (GO:0006760)2.60928430
99gene silencing by RNA (GO:0031047)2.59718196
100aspartate family amino acid biosynthetic process (GO:0009067)2.58092905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.18638915
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84415273
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74314072
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42264779
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.14955198
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.89695088
7VDR_22108803_ChIP-Seq_LS180_Human2.77870704
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.73948893
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.67376780
10EZH2_22144423_ChIP-Seq_EOC_Human2.63472723
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.48399840
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.46867188
13GATA1_22025678_ChIP-Seq_K562_Human2.45311056
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42761136
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.42658407
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39472615
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.36171504
18GATA1_19941826_ChIP-Seq_K562_Human2.36063571
19NCOR1_26117541_ChIP-Seq_K562_Human2.30078825
20ELK1_19687146_ChIP-ChIP_HELA_Human2.17613142
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17609304
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16731813
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15871355
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08902413
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02010338
26VDR_23849224_ChIP-Seq_CD4+_Human1.92930523
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.85585839
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82023823
29GATA2_19941826_ChIP-Seq_K562_Human1.78512537
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77137221
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74653453
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74561667
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.71847909
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71006975
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71000096
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.69190139
37TTF2_22483619_ChIP-Seq_HELA_Human1.65019646
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64082350
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62426374
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62128014
41FOXP3_21729870_ChIP-Seq_TREG_Human1.60571745
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60251367
43KDM5A_27292631_Chip-Seq_BREAST_Human1.58217440
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58147263
45XRN2_22483619_ChIP-Seq_HELA_Human1.58123334
46ZNF274_21170338_ChIP-Seq_K562_Hela1.56010877
47CIITA_25753668_ChIP-Seq_RAJI_Human1.54900797
48PHF8_20622853_ChIP-Seq_HELA_Human1.50704532
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49551599
50DCP1A_22483619_ChIP-Seq_HELA_Human1.46711827
51EWS_26573619_Chip-Seq_HEK293_Human1.45192460
52GATA6_21074721_ChIP-Seq_CACO-2_Human1.40864338
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37211494
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.35134917
55GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.34968798
56MYC_18940864_ChIP-ChIP_HL60_Human1.32021825
57SCL_19346495_ChIP-Seq_HPC-7_Human1.31195256
58RBPJ_21746931_ChIP-Seq_IB4_Human1.29911991
59NFYB_21822215_ChIP-Seq_K562_Human1.29256933
60ETV1_20927104_ChIP-Seq_GIST48_Human1.29122436
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29032512
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27044719
63ER_23166858_ChIP-Seq_MCF-7_Human1.26099914
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22569501
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.21849897
66GABP_19822575_ChIP-Seq_HepG2_Human1.19205712
67IGF1R_20145208_ChIP-Seq_DFB_Human1.19076596
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18806730
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18738388
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18318593
71NFYA_21822215_ChIP-Seq_K562_Human1.17144915
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16865463
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16512577
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15380129
75SPI1_23127762_ChIP-Seq_K562_Human1.12435332
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.11981279
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02141241
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01908207
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01353019
80E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98415200
81TP53_22573176_ChIP-Seq_HFKS_Human0.96951927
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94030710
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92698209
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92565996
85TBL1_22424771_ChIP-Seq_293T_Human0.92287476
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91142527
87AR_21909140_ChIP-Seq_LNCAP_Human0.88424596
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86049377
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82899271
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81167333
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79435709
92SALL4_22934838_ChIP-ChIP_CD34+_Human0.79184316
93FUS_26573619_Chip-Seq_HEK293_Human0.78012929
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77975618
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77325419
96JUN_21703547_ChIP-Seq_K562_Human0.74484302
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.73546682
98TFEB_21752829_ChIP-Seq_HELA_Human0.71253318
99TAF15_26573619_Chip-Seq_HEK293_Human0.68329156
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67316160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.40391384
2MP0008995_early_reproductive_senescence3.71074237
3MP0010094_abnormal_chromosome_stability3.66008953
4MP0008058_abnormal_DNA_repair3.59234139
5MP0008057_abnormal_DNA_replication3.56306992
6MP0003656_abnormal_erythrocyte_physiolo3.36592702
7MP0009697_abnormal_copulation3.36020347
8MP0005451_abnormal_body_composition3.21377973
9MP0003693_abnormal_embryo_hatching3.01122056
10MP0004957_abnormal_blastocyst_morpholog2.95073894
11MP0003111_abnormal_nucleus_morphology2.82624398
12MP0005083_abnormal_biliary_tract2.55090089
13MP0003786_premature_aging2.54220965
14MP0000678_abnormal_parathyroid_gland2.48539610
15MP0004145_abnormal_muscle_electrophysio2.31205717
16MP0003718_maternal_effect2.03944131
17MP0008932_abnormal_embryonic_tissue1.94974332
18MP0008007_abnormal_cellular_replicative1.91878313
19MP0003077_abnormal_cell_cycle1.81851653
20MP0000372_irregular_coat_pigmentation1.78800280
21MP0002102_abnormal_ear_morphology1.72076224
22MP0008877_abnormal_DNA_methylation1.70707714
23MP0005645_abnormal_hypothalamus_physiol1.70672514
24MP0001929_abnormal_gametogenesis1.64438162
25MP0001545_abnormal_hematopoietic_system1.60649659
26MP0005397_hematopoietic_system_phenotyp1.60649659
27MP0003186_abnormal_redox_activity1.55999985
28MP0006036_abnormal_mitochondrial_physio1.53107935
29MP0002396_abnormal_hematopoietic_system1.52631905
30MP0002210_abnormal_sex_determination1.52315955
31MP0005410_abnormal_fertilization1.48788059
32MP0002009_preneoplasia1.40589602
33MP0003646_muscle_fatigue1.36634668
34MP0005636_abnormal_mineral_homeostasis1.33863659
35MP0010307_abnormal_tumor_latency1.33412003
36MP0003698_abnormal_male_reproductive1.32985855
37MP0003950_abnormal_plasma_membrane1.26387217
38MP0006035_abnormal_mitochondrial_morpho1.24331902
39MP0000631_abnormal_neuroendocrine_gland1.22262630
40MP0001697_abnormal_embryo_size1.20881549
41MP0001730_embryonic_growth_arrest1.16811589
42MP0001661_extended_life_span1.16436858
43MP0000653_abnormal_sex_gland1.14216871
44MP0006292_abnormal_olfactory_placode1.14006968
45MP0000313_abnormal_cell_death1.08450058
46MP0001145_abnormal_male_reproductive1.07132251
47MP0003221_abnormal_cardiomyocyte_apopto1.06217964
48MP0001764_abnormal_homeostasis1.05999132
49MP0000350_abnormal_cell_proliferation1.05585501
50MP0004134_abnormal_chest_morphology1.00099554
51MP0001529_abnormal_vocalization0.99704502
52MP0001672_abnormal_embryogenesis/_devel0.98354359
53MP0005380_embryogenesis_phenotype0.98354359
54MP0008872_abnormal_physiological_respon0.97024043
55MP0004233_abnormal_muscle_weight0.96998551
56MP0008775_abnormal_heart_ventricle0.95780746
57MP0002095_abnormal_skin_pigmentation0.95616613
58MP0006276_abnormal_autonomic_nervous0.93105731
59MP0002132_abnormal_respiratory_system0.92118290
60MP0005551_abnormal_eye_electrophysiolog0.90572434
61MP0005408_hypopigmentation0.89869254
62MP0002080_prenatal_lethality0.89692393
63MP0000647_abnormal_sebaceous_gland0.89262440
64MP0002139_abnormal_hepatobiliary_system0.87486394
65MP0000703_abnormal_thymus_morphology0.86397803
66MP0003984_embryonic_growth_retardation0.84322284
67MP0002088_abnormal_embryonic_growth/wei0.83666738
68MP0002877_abnormal_melanocyte_morpholog0.83606395
69MP0009046_muscle_twitch0.83343707
70MP0005253_abnormal_eye_physiology0.83024159
71MP0002019_abnormal_tumor_incidence0.82761170
72MP0002161_abnormal_fertility/fecundity0.82086547
73MP0003385_abnormal_body_wall0.79661246
74MP0005535_abnormal_body_temperature0.77491506
75MP0008770_decreased_survivor_rate0.77374928
76MP0003699_abnormal_female_reproductive0.75989391
77MP0005646_abnormal_pituitary_gland0.75820833
78MP0001119_abnormal_female_reproductive0.75206905
79MP0003890_abnormal_embryonic-extraembry0.74605721
80MP0002086_abnormal_extraembryonic_tissu0.73695253
81MP0005389_reproductive_system_phenotype0.73158670
82MP0004043_abnormal_pH_regulation0.72732509
83MP0000609_abnormal_liver_physiology0.70667329
84MP0002160_abnormal_reproductive_system0.70302637
85MP0002398_abnormal_bone_marrow0.70222166
86MP0004808_abnormal_hematopoietic_stem0.69908726
87MP0001873_stomach_inflammation0.69801576
88MP0002084_abnormal_developmental_patter0.69668285
89MP0004019_abnormal_vitamin_homeostasis0.69274380
90MP0003959_abnormal_lean_body0.69213394
91MP0002234_abnormal_pharynx_morphology0.68916165
92MP0004085_abnormal_heartbeat0.68876023
93MP0005332_abnormal_amino_acid0.68107862
94MP0002269_muscular_atrophy0.66961599
95MP0009115_abnormal_fat_cell0.65131422
96MP0002722_abnormal_immune_system0.64645329
97MP0004084_abnormal_cardiac_muscle0.64638846
98MP0003937_abnormal_limbs/digits/tail_de0.63979238
99MP0005266_abnormal_metabolism0.63481760
100MP0005171_absent_coat_pigmentation0.62120356

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)6.64237988
2Abnormal gallbladder physiology (HP:0012438)6.64237988
3Truncus arteriosus (HP:0001660)5.92664965
4Birth length less than 3rd percentile (HP:0003561)4.76164243
5Reticulocytosis (HP:0001923)4.39303740
6Hyperthyroidism (HP:0000836)4.39151160
7Ankyloglossia (HP:0010296)3.97989695
8Polycythemia (HP:0001901)3.65296596
9Abnormality of reticulocytes (HP:0004312)3.62040523
10Homocystinuria (HP:0002156)3.61491961
11Abnormality of homocysteine metabolism (HP:0010919)3.61491961
12Bowel incontinence (HP:0002607)3.58795809
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.54771415
14Abnormal hemoglobin (HP:0011902)3.44364483
15Poikilocytosis (HP:0004447)3.43466223
16Abnormal large intestine physiology (HP:0012700)3.41990553
17Chromsome breakage (HP:0040012)3.33730159
18Ileus (HP:0002595)3.31807268
19Tinnitus (HP:0000360)3.26478319
20Upper limb muscle weakness (HP:0003484)3.21126442
21Hypertensive crisis (HP:0100735)3.08267559
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02318858
23Abnormality of glycolysis (HP:0004366)2.99392945
24Acute myeloid leukemia (HP:0004808)2.93725454
25Increased serum pyruvate (HP:0003542)2.84531239
26Seborrheic dermatitis (HP:0001051)2.83331830
27Cholelithiasis (HP:0001081)2.82782430
28Nonimmune hydrops fetalis (HP:0001790)2.72293352
29Hypoparathyroidism (HP:0000829)2.71619318
30Abnormality of cochlea (HP:0000375)2.66315724
31Abnormality of oral frenula (HP:0000190)2.63905192
32Abnormal gallbladder morphology (HP:0012437)2.62322990
33Acanthocytosis (HP:0001927)2.50149762
34Abnormality of the pons (HP:0007361)2.48846500
35Pallor (HP:0000980)2.46647287
36Hypoplasia of the pons (HP:0012110)2.43990558
37Aplasia/Hypoplasia of the earlobes (HP:0009906)2.40503661
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.30357830
39Hyperbilirubinemia (HP:0002904)2.27218362
40Cortical dysplasia (HP:0002539)2.27020838
41Retinal dysplasia (HP:0007973)2.25274052
42Myelodysplasia (HP:0002863)2.23258697
43Flat cornea (HP:0007720)2.22270158
44Abnormality of chromosome stability (HP:0003220)2.22192821
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.19866232
46Type II lissencephaly (HP:0007260)2.15533265
47Sandal gap (HP:0001852)2.12789734
48Duplicated collecting system (HP:0000081)2.11817750
49Abnormality of the gallbladder (HP:0005264)2.11073742
50Abnormality of the preputium (HP:0100587)2.10193838
51Pheochromocytoma (HP:0002666)2.10026449
52Abnormality of the tricuspid valve (HP:0001702)2.05036570
53Abnormality of DNA repair (HP:0003254)2.04624545
54Gaze-evoked nystagmus (HP:0000640)2.03211297
55Poikiloderma (HP:0001029)2.02711615
56Reticulocytopenia (HP:0001896)1.98929288
57Abnormality of the renal collecting system (HP:0004742)1.98369409
58Small hand (HP:0200055)1.97990316
59Abnormally folded helix (HP:0008544)1.97518593
60Aplasia/Hypoplasia of the thymus (HP:0010515)1.96518287
61Abnormality of the renal cortex (HP:0011035)1.95188679
62Morphological abnormality of the inner ear (HP:0011390)1.95017994
63Long clavicles (HP:0000890)1.94958021
64Concave nail (HP:0001598)1.94400016
65Atelectasis (HP:0100750)1.93830997
66Neuroendocrine neoplasm (HP:0100634)1.92022107
67Duodenal stenosis (HP:0100867)1.86656163
68Small intestinal stenosis (HP:0012848)1.86656163
69Cutaneous melanoma (HP:0012056)1.86103893
70Combined immunodeficiency (HP:0005387)1.82858335
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81375747
72Dysmetric saccades (HP:0000641)1.80399159
73Oculomotor apraxia (HP:0000657)1.79942980
74Attention deficit hyperactivity disorder (HP:0007018)1.79575868
75Cheekbone underdevelopment (HP:0010669)1.74675234
76Abnormal number of erythroid precursors (HP:0012131)1.74581533
77Breast hypoplasia (HP:0003187)1.74361838
78Severe combined immunodeficiency (HP:0004430)1.73410100
79Abnormality of the labia minora (HP:0012880)1.71936525
80Breech presentation (HP:0001623)1.71572378
81Sloping forehead (HP:0000340)1.71388198
82Meckel diverticulum (HP:0002245)1.70780123
83Renal cortical cysts (HP:0000803)1.70428967
84Orthostatic hypotension (HP:0001278)1.65565440
85Pancreatic fibrosis (HP:0100732)1.65211557
86Abnormality of the ileum (HP:0001549)1.65003740
87Abnormality of cells of the erythroid lineage (HP:0012130)1.63492879
88Obsessive-compulsive behavior (HP:0000722)1.62992681
89Premature ovarian failure (HP:0008209)1.62287320
90Angiofibromas (HP:0010615)1.61505262
91Adenoma sebaceum (HP:0009720)1.61505262
92Pancreatic islet-cell hyperplasia (HP:0004510)1.61043863
93Abnormality of the carotid arteries (HP:0005344)1.60946090
94Pancreatic cysts (HP:0001737)1.60784066
95Abnormality of the labia majora (HP:0012881)1.60326279
96Ventricular fibrillation (HP:0001663)1.60193600
97Overlapping toe (HP:0001845)1.60059162
98Prolonged QT interval (HP:0001657)1.59247457
99Metaphyseal dysplasia (HP:0100255)1.58414100
100Overfolded helix (HP:0000396)1.57193199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.68194619
2NTRK33.86161296
3EIF2AK13.79327633
4KSR23.56941404
5BMPR23.16301723
6TTK2.94034964
7MAP3K22.89915899
8RAF12.85453758
9CLK12.67608663
10MAP3K42.35874638
11PLK42.33384321
12KSR12.22491122
13BRSK22.19529658
14CDC72.03615748
15FRK2.02794037
16EEF2K1.89569199
17CCNB11.88764941
18WEE11.75461561
19NEK11.60171124
20SRPK11.54611910
21NEK21.52841758
22EIF2AK31.49363839
23NME11.47891801
24MAP3K61.47316126
25WNK41.38646097
26CHEK21.34912570
27MAP3K81.34050691
28BUB11.28437354
29PDK21.18122350
30STK31.14301550
31PBK1.14032736
32BMX1.11569697
33DYRK31.10968568
34TEC1.08338835
35ATR1.05091588
36MST41.03254046
37RPS6KB21.02439667
38PLK31.02253915
39MAP2K71.01842576
40MAP2K10.95946466
41ZAK0.95301180
42SCYL20.91159960
43TRPM70.90347584
44MKNK10.87201631
45ATM0.87114038
46PLK10.85524467
47MAP4K20.84844467
48PIK3CG0.84460313
49MARK30.83625175
50INSRR0.82142819
51TSSK60.79324014
52AKT30.79297435
53RPS6KA40.78351056
54TNIK0.77628926
55TAOK30.77236789
56CDK10.72103782
57STK160.71354403
58CHEK10.71349744
59BRAF0.71121361
60RET0.69353701
61BRSK10.69199765
62MKNK20.69146450
63JAK20.68990592
64MAPKAPK50.68982483
65PIM10.66581824
66ALK0.64842155
67PLK20.59688611
68ADRBK20.57827119
69CDK20.56825313
70MAPK130.54802331
71PASK0.54408154
72STK40.48202805
73CDK120.48168690
74BTK0.48122647
75NUAK10.45865967
76PINK10.44843910
77CSNK2A20.43685142
78BCR0.43152393
79PTK2B0.40338116
80CSNK2A10.39943498
81AURKB0.38546661
82CSNK1E0.38467086
83BMPR1B0.37190604
84MAPKAPK30.37001048
85ERBB30.36210682
86WNK30.34867452
87EIF2AK20.34382972
88WNK10.33034915
89NEK60.32860333
90ICK0.32667403
91GSK3B0.32382507
92MATK0.32057140
93PRKAA10.31844405
94MAP3K10.31705419
95PRKCB0.31222958
96MAP3K70.29727907
97MAP2K60.29696209
98PAK10.29350894
99SGK10.28915350
100CDK30.27638878

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.33877547
2One carbon pool by folate_Homo sapiens_hsa006704.29573974
3Homologous recombination_Homo sapiens_hsa034403.63659107
4Mismatch repair_Homo sapiens_hsa034303.46840900
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.17528254
6Fanconi anemia pathway_Homo sapiens_hsa034602.75591623
7DNA replication_Homo sapiens_hsa030302.73447343
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58010145
9RNA transport_Homo sapiens_hsa030132.41830756
10Basal transcription factors_Homo sapiens_hsa030222.31654053
11Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.10306649
12Olfactory transduction_Homo sapiens_hsa047402.09610022
13Nucleotide excision repair_Homo sapiens_hsa034202.02975889
14Pyruvate metabolism_Homo sapiens_hsa006201.83715561
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80882825
16Spliceosome_Homo sapiens_hsa030401.79790628
17Steroid biosynthesis_Homo sapiens_hsa001001.79461117
18Cell cycle_Homo sapiens_hsa041101.68767252
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65980850
20Butanoate metabolism_Homo sapiens_hsa006501.61404472
21RNA degradation_Homo sapiens_hsa030181.58698193
22Non-homologous end-joining_Homo sapiens_hsa034501.57640653
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.47996938
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.44986815
25RNA polymerase_Homo sapiens_hsa030201.43075485
26Propanoate metabolism_Homo sapiens_hsa006401.40361017
27Ribosome_Homo sapiens_hsa030101.39294468
28mRNA surveillance pathway_Homo sapiens_hsa030151.36144886
29Selenocompound metabolism_Homo sapiens_hsa004501.33699575
30Carbon metabolism_Homo sapiens_hsa012001.29201722
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28205610
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26060802
33Nicotine addiction_Homo sapiens_hsa050331.16531900
34Biosynthesis of amino acids_Homo sapiens_hsa012301.12107870
35Nitrogen metabolism_Homo sapiens_hsa009101.09367184
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06384771
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04216367
38Base excision repair_Homo sapiens_hsa034101.03705374
39Linoleic acid metabolism_Homo sapiens_hsa005911.01859733
40Oocyte meiosis_Homo sapiens_hsa041140.97721744
41Cyanoamino acid metabolism_Homo sapiens_hsa004600.96686580
42Protein export_Homo sapiens_hsa030600.94398870
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92094851
44Purine metabolism_Homo sapiens_hsa002300.92070810
45Type II diabetes mellitus_Homo sapiens_hsa049300.91333313
46Pyrimidine metabolism_Homo sapiens_hsa002400.87288111
47Oxidative phosphorylation_Homo sapiens_hsa001900.84043731
48Parkinsons disease_Homo sapiens_hsa050120.82011982
49Proteasome_Homo sapiens_hsa030500.81920241
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80469577
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78772208
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78141815
53Fatty acid metabolism_Homo sapiens_hsa012120.74554302
54Huntingtons disease_Homo sapiens_hsa050160.74136912
55Ether lipid metabolism_Homo sapiens_hsa005650.72798743
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72017254
57Acute myeloid leukemia_Homo sapiens_hsa052210.67861711
58Arginine biosynthesis_Homo sapiens_hsa002200.65769426
59Pentose phosphate pathway_Homo sapiens_hsa000300.63150325
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58918193
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57115540
62Metabolic pathways_Homo sapiens_hsa011000.56992664
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56607855
64Retinol metabolism_Homo sapiens_hsa008300.56046429
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54836762
66Fatty acid elongation_Homo sapiens_hsa000620.54176348
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52558151
68Phototransduction_Homo sapiens_hsa047440.50600208
69Fatty acid biosynthesis_Homo sapiens_hsa000610.48443274
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47894415
71mTOR signaling pathway_Homo sapiens_hsa041500.46941901
72Taste transduction_Homo sapiens_hsa047420.46751110
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46147310
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45769674
75Glutathione metabolism_Homo sapiens_hsa004800.45320805
76VEGF signaling pathway_Homo sapiens_hsa043700.44087338
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.41862030
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41778129
79N-Glycan biosynthesis_Homo sapiens_hsa005100.41318449
80Fructose and mannose metabolism_Homo sapiens_hsa000510.39199481
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36810593
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34471771
83Peroxisome_Homo sapiens_hsa041460.34079669
84ABC transporters_Homo sapiens_hsa020100.32913893
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32717351
86Viral carcinogenesis_Homo sapiens_hsa052030.31626592
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31539735
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31240341
89Chronic myeloid leukemia_Homo sapiens_hsa052200.26442784
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23132088
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22838293
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21902354
93Thyroid cancer_Homo sapiens_hsa052160.20524737
94Alzheimers disease_Homo sapiens_hsa050100.20161055
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19909525
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.19590467
97HIF-1 signaling pathway_Homo sapiens_hsa040660.19561637
98ErbB signaling pathway_Homo sapiens_hsa040120.17971479
99Primary immunodeficiency_Homo sapiens_hsa053400.16199016
100Lysine degradation_Homo sapiens_hsa003100.16152778

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