SSX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of protein glycosylation (GO:0060049)8.54322731
2negative regulation of cytosolic calcium ion concentration (GO:0051481)8.31363650
3negative regulation of glycoprotein biosynthetic process (GO:0010561)7.64448844
4piRNA metabolic process (GO:0034587)7.56380802
5DNA methylation involved in gamete generation (GO:0043046)7.47442973
6regulation of translational termination (GO:0006449)7.40625872
7lipopolysaccharide biosynthetic process (GO:0009103)6.75750983
8negative regulation of cAMP-mediated signaling (GO:0043951)6.72884414
9notochord development (GO:0030903)6.58873373
10protein-chromophore linkage (GO:0018298)6.44907737
11opioid receptor signaling pathway (GO:0038003)6.43856669
12regulation of odontogenesis of dentin-containing tooth (GO:0042487)6.37398224
13regulation of meiosis I (GO:0060631)6.25171845
14lipopolysaccharide metabolic process (GO:0008653)5.82047132
15behavioral response to ethanol (GO:0048149)5.81562613
16negative regulation of glycoprotein metabolic process (GO:1903019)5.53392921
17ether lipid metabolic process (GO:0046485)5.45836687
18negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.34932813
19adult feeding behavior (GO:0008343)5.26653123
20negative regulation of calcium ion-dependent exocytosis (GO:0045955)5.25437165
21sulfate transmembrane transport (GO:1902358)5.11496448
22ribonucleoprotein complex disassembly (GO:0032988)4.89879010
23regulation of pigment cell differentiation (GO:0050932)4.78404947
24positive regulation of developmental pigmentation (GO:0048087)4.72386828
25positive regulation of cAMP-mediated signaling (GO:0043950)4.69835370
26negative regulation of cell cycle G2/M phase transition (GO:1902750)4.64349402
27sulfate transport (GO:0008272)4.62571784
28meiotic chromosome segregation (GO:0045132)4.52418531
29regulation of acrosome reaction (GO:0060046)4.42611318
30adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.42042859
31negative regulation of cell-matrix adhesion (GO:0001953)4.25368810
32regulation of odontogenesis (GO:0042481)4.19489783
33regulation of rhodopsin mediated signaling pathway (GO:0022400)4.16865678
34heme transport (GO:0015886)4.07827436
35paraxial mesoderm development (GO:0048339)4.06384837
36rhodopsin mediated signaling pathway (GO:0016056)3.82198389
37serotonin receptor signaling pathway (GO:0007210)3.75276286
38centriole replication (GO:0007099)3.73171803
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72968321
40tyrosine metabolic process (GO:0006570)3.67959783
41thrombin receptor signaling pathway (GO:0070493)3.65782866
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.61649843
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61596567
44L-phenylalanine catabolic process (GO:0006559)3.61596567
45nodal signaling pathway (GO:0038092)3.60461033
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.51060942
47regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.50072826
48tachykinin receptor signaling pathway (GO:0007217)3.49311018
49gene silencing by RNA (GO:0031047)3.43520006
50DNA damage induced protein phosphorylation (GO:0006975)3.42032416
51polyol biosynthetic process (GO:0046173)3.36791627
52indolalkylamine metabolic process (GO:0006586)3.34202806
53negative regulation of nitric oxide biosynthetic process (GO:0045019)3.29875811
54regulation of glutamate receptor signaling pathway (GO:1900449)3.20616460
55positive regulation of meiosis (GO:0045836)3.20146738
56urate metabolic process (GO:0046415)3.19624122
57SMAD protein complex assembly (GO:0007183)3.14829172
58meiotic cell cycle (GO:0051321)3.13858193
59L-phenylalanine metabolic process (GO:0006558)3.09528395
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.09528395
61dicarboxylic acid catabolic process (GO:0043649)3.07662180
62DNA replication-dependent nucleosome assembly (GO:0006335)3.07325454
63DNA replication-dependent nucleosome organization (GO:0034723)3.07325454
64aromatic amino acid family catabolic process (GO:0009074)3.03346430
65DNA alkylation (GO:0006305)2.99575927
66DNA methylation (GO:0006306)2.99575927
67flavonoid metabolic process (GO:0009812)2.98362460
68organelle disassembly (GO:1903008)2.97663557
69positive regulation of meiotic cell cycle (GO:0051446)2.95854604
70aspartate family amino acid catabolic process (GO:0009068)2.93816155
71cellular response to ammonium ion (GO:0071242)2.85296283
72cellular response to alkaloid (GO:0071312)2.81410419
73glycerol ether metabolic process (GO:0006662)2.81278626
74sphingolipid biosynthetic process (GO:0030148)2.79280783
75aromatic amino acid family metabolic process (GO:0009072)2.78647085
76iron coordination entity transport (GO:1901678)2.77164660
77glycerol metabolic process (GO:0006071)2.76989242
78sulfur compound transport (GO:0072348)2.76511609
79regulation of cAMP-mediated signaling (GO:0043949)2.76173646
80regulation of translational elongation (GO:0006448)2.75998786
81vitamin transmembrane transport (GO:0035461)2.74851199
82germinal center formation (GO:0002467)2.74193743
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.73976206
84thyroid hormone metabolic process (GO:0042403)2.71063301
85negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.67042812
86membrane lipid biosynthetic process (GO:0046467)2.65634397
87inner cell mass cell proliferation (GO:0001833)2.62963356
88spermatid development (GO:0007286)2.62744712
89thyroid hormone generation (GO:0006590)2.60508446
90adaptation of signaling pathway (GO:0023058)2.60193958
91regulation of glycoprotein biosynthetic process (GO:0010559)2.59853155
92tetrahydrofolate metabolic process (GO:0046653)2.59751495
93left/right axis specification (GO:0070986)2.59598146
94biotin metabolic process (GO:0006768)2.59427005
95detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.58304106
96ether metabolic process (GO:0018904)2.56184174
97reciprocal DNA recombination (GO:0035825)2.55321682
98sphingosine metabolic process (GO:0006670)15.2420126
99diol metabolic process (GO:0034311)13.7303322
100sphingoid metabolic process (GO:0046519)12.8011273

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.64693213
2IGF1R_20145208_ChIP-Seq_DFB_Human4.01566181
3AR_21572438_ChIP-Seq_LNCaP_Human3.96384564
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.41607030
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.34684422
6VDR_22108803_ChIP-Seq_LS180_Human3.33844014
7E2F7_22180533_ChIP-Seq_HELA_Human2.62808750
8GBX2_23144817_ChIP-Seq_PC3_Human2.62499931
9EGR1_19032775_ChIP-ChIP_M12_Human2.57633316
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41833684
11ZNF274_21170338_ChIP-Seq_K562_Hela2.32978958
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31134933
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.31134933
14NANOG_19829295_ChIP-Seq_ESCs_Human2.11419400
15SOX2_19829295_ChIP-Seq_ESCs_Human2.11419400
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.06073222
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.99512418
18ER_23166858_ChIP-Seq_MCF-7_Human1.88250941
19TCF4_23295773_ChIP-Seq_U87_Human1.85653561
20STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.84306920
21EZH2_22144423_ChIP-Seq_EOC_Human1.82656793
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.81048478
23SCL_19346495_ChIP-Seq_HPC-7_Human1.80318242
24STAT3_23295773_ChIP-Seq_U87_Human1.77361029
25TAF15_26573619_Chip-Seq_HEK293_Human1.76421638
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75289118
27P300_19829295_ChIP-Seq_ESCs_Human1.69483550
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.67192232
29GATA3_21878914_ChIP-Seq_MCF-7_Human1.65628727
30STAT1_20625510_ChIP-Seq_HELA_Human1.64788938
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63826106
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58770376
33HOXB7_26014856_ChIP-Seq_BT474_Human1.55299603
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49806372
35RXR_22108803_ChIP-Seq_LS180_Human1.49088887
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.47987395
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45020467
38FOXH1_21741376_ChIP-Seq_ESCs_Human1.44957503
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39463323
40CBP_20019798_ChIP-Seq_JUKART_Human1.38382412
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38382412
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37905714
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36399179
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33077362
45OCT4_20526341_ChIP-Seq_ESCs_Human1.32680733
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32461496
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32396488
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32011435
49CEBPB_22108803_ChIP-Seq_LS180_Human1.31440350
50NANOG_20526341_ChIP-Seq_ESCs_Human1.30708302
51OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28278406
52CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28275206
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27528244
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.26753032
55FLI1_21867929_ChIP-Seq_TH2_Mouse1.24737123
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23708997
57CRX_20693478_ChIP-Seq_RETINA_Mouse1.23621177
58OCT1_27270436_Chip-Seq_PROSTATE_Human1.22948243
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21964927
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21824493
61RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21485860
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20978244
63CDX2_22108803_ChIP-Seq_LS180_Human1.20580124
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.18328598
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16908056
66LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16083918
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15327103
68NCOR_22424771_ChIP-Seq_293T_Human1.15130980
69AR_25329375_ChIP-Seq_VCAP_Human1.14366297
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13943275
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13400026
72TP53_16413492_ChIP-PET_HCT116_Human1.12491572
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.11329469
74GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.11315640
75SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10918412
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10461991
77P53_21459846_ChIP-Seq_SAOS-2_Human1.10071408
78TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09364500
79SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08513637
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08042428
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07367067
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04520379
83SMAD4_21799915_ChIP-Seq_A2780_Human1.04484104
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.03891125
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03051848
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02085289
87GATA1_19941826_ChIP-Seq_K562_Human1.01811062
88TP53_22573176_ChIP-Seq_HFKS_Human1.00758453
89STAT3_18555785_ChIP-Seq_MESCs_Mouse1.00279836
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99698639
91AR_19668381_ChIP-Seq_PC3_Human0.97724607
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.96228487
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95924547
94FOXA1_25329375_ChIP-Seq_VCAP_Human0.95924547
95GATA3_26560356_Chip-Seq_TH1_Human0.93133953
96TCF4_22108803_ChIP-Seq_LS180_Human0.92772563
97GATA3_21867929_ChIP-Seq_TH1_Mouse0.92430721
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.92365138
99TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92115680
100BCAT_22108803_ChIP-Seq_LS180_Human0.91531168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.32983420
2MP0003136_yellow_coat_color6.50783501
3MP0005171_absent_coat_pigmentation6.03150534
4MP0003045_fibrosis4.71309252
5MP0002653_abnormal_ependyma_morphology4.65194324
6MP0003646_muscle_fatigue4.14008361
7MP0003890_abnormal_embryonic-extraembry3.83413204
8MP0003879_abnormal_hair_cell3.48369529
9MP0009278_abnormal_bone_marrow3.05379612
10MP0004147_increased_porphyrin_level2.87074253
11MP0002876_abnormal_thyroid_physiology2.71671477
12MP0000569_abnormal_digit_pigmentation2.69996656
13MP0005670_abnormal_white_adipose2.39590736
14MP0004381_abnormal_hair_follicle2.10311147
15MP0002138_abnormal_hepatobiliary_system2.03299670
16MP0003195_calcinosis2.00045599
17MP0005085_abnormal_gallbladder_physiolo1.91277498
18MP0000749_muscle_degeneration1.90984818
19MP0005360_urolithiasis1.90653907
20MP0002168_other_aberrant_phenotype1.84870945
21MP0003950_abnormal_plasma_membrane1.79967569
22MP0009780_abnormal_chondrocyte_physiolo1.69586643
23MP0008057_abnormal_DNA_replication1.68297596
24MP0000678_abnormal_parathyroid_gland1.65623618
25MP0001501_abnormal_sleep_pattern1.63863753
26MP0001968_abnormal_touch/_nociception1.63677055
27MP0004233_abnormal_muscle_weight1.53017922
28MP0005503_abnormal_tendon_morphology1.47622290
29MP0009764_decreased_sensitivity_to1.33291648
30MP0002938_white_spotting1.33097701
31MP0002095_abnormal_skin_pigmentation1.31561657
32MP0005395_other_phenotype1.23835125
33MP0000015_abnormal_ear_pigmentation1.20868927
34MP0003705_abnormal_hypodermis_morpholog1.15659998
35MP0003183_abnormal_peptide_metabolism1.15568736
36MP0005551_abnormal_eye_electrophysiolog1.15515322
37MP0005075_abnormal_melanosome_morpholog1.14519803
38MP0004043_abnormal_pH_regulation1.14152461
39MP0001545_abnormal_hematopoietic_system1.14136484
40MP0005397_hematopoietic_system_phenotyp1.14136484
41MP0005646_abnormal_pituitary_gland1.10286490
42MP0003941_abnormal_skin_development1.10038986
43MP0006035_abnormal_mitochondrial_morpho1.09900162
44MP0003959_abnormal_lean_body1.09761139
45MP0000681_abnormal_thyroid_gland1.06623682
46MP0010352_gastrointestinal_tract_polyps1.02667374
47MP0002971_abnormal_brown_adipose0.98598281
48MP0005365_abnormal_bile_salt0.95888137
49MP0001664_abnormal_digestion0.92725841
50MP0002160_abnormal_reproductive_system0.90576566
51MP0009046_muscle_twitch0.85585717
52MP0002269_muscular_atrophy0.78826901
53MP0002075_abnormal_coat/hair_pigmentati0.77724421
54MP0001486_abnormal_startle_reflex0.77034094
55MP0002733_abnormal_thermal_nociception0.76026521
56MP0009745_abnormal_behavioral_response0.73067993
57MP0005174_abnormal_tail_pigmentation0.72584743
58MP0002272_abnormal_nervous_system0.72142336
59MP0004130_abnormal_muscle_cell0.71455281
60MP0003937_abnormal_limbs/digits/tail_de0.69873408
61MP0005377_hearing/vestibular/ear_phenot0.66186171
62MP0003878_abnormal_ear_physiology0.66186171
63MP0006054_spinal_hemorrhage0.64592318
64MP0008872_abnormal_physiological_respon0.64286919
65MP0001661_extended_life_span0.62430802
66MP0000427_abnormal_hair_cycle0.62339125
67MP0001970_abnormal_pain_threshold0.61822141
68MP0003718_maternal_effect0.61304858
69MP0010094_abnormal_chromosome_stability0.60202874
70MP0005389_reproductive_system_phenotype0.59511234
71MP0003137_abnormal_impulse_conducting0.59286225
72MP0005330_cardiomyopathy0.58823605
73MP0008770_decreased_survivor_rate0.58038790
74MP0003252_abnormal_bile_duct0.57978995
75MP0001324_abnormal_eye_pigmentation0.57517995
76MP0000230_abnormal_systemic_arterial0.56317130
77MP0002735_abnormal_chemical_nociception0.55592242
78MP0002229_neurodegeneration0.54825029
79MP0002102_abnormal_ear_morphology0.54771186
80MP0009333_abnormal_splenocyte_physiolog0.53877730
81MP0004957_abnormal_blastocyst_morpholog0.53430319
82MP0005410_abnormal_fertilization0.53214205
83MP0008874_decreased_physiological_sensi0.51670670
84MP0003698_abnormal_male_reproductive0.50726027
85MP0001929_abnormal_gametogenesis0.49965982
86MP0003638_abnormal_response/metabolism_0.49962056
87MP0002210_abnormal_sex_determination0.49024531
88MP0005319_abnormal_enzyme/_coenzyme0.47343607
89MP0002396_abnormal_hematopoietic_system0.46974378
90MP0010307_abnormal_tumor_latency0.45738362
91MP0003633_abnormal_nervous_system0.45179702
92MP0001986_abnormal_taste_sensitivity0.44793507
93MP0008058_abnormal_DNA_repair0.40847549
94MP0002254_reproductive_system_inflammat0.40639337
95MP0000358_abnormal_cell_content/0.40407713
96MP0006276_abnormal_autonomic_nervous0.40330566
97MP0001186_pigmentation_phenotype0.40260645
98MP0006036_abnormal_mitochondrial_physio0.37603260
99MP0001881_abnormal_mammary_gland0.36869768
100MP0005266_abnormal_metabolism0.36646382

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.18654848
2Thyroid-stimulating hormone excess (HP:0002925)8.03235518
3Amelogenesis imperfecta (HP:0000705)7.86744228
4Acanthocytosis (HP:0001927)5.56901478
5Congenital ichthyosiform erythroderma (HP:0007431)5.03891277
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.71475506
7Parakeratosis (HP:0001036)4.65677787
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.60485556
9Dialeptic seizures (HP:0011146)4.48607149
10Aplastic anemia (HP:0001915)4.39752037
11Chromsome breakage (HP:0040012)4.25345594
12Volvulus (HP:0002580)4.22266737
13Pancreatic islet-cell hyperplasia (HP:0004510)4.17778329
14Aplasia/Hypoplasia of the uvula (HP:0010293)4.06431432
15Ileus (HP:0002595)3.66430539
16Focal seizures (HP:0007359)3.56591986
17Intestinal atresia (HP:0011100)3.53107968
18Large for gestational age (HP:0001520)3.50570500
19Cerebellar dysplasia (HP:0007033)3.22127148
20Poikilocytosis (HP:0004447)3.21048111
21Poor head control (HP:0002421)3.13827732
22Difficulty walking (HP:0002355)3.09828489
23Pancreatic cysts (HP:0001737)3.09086698
24Abnormality of the aortic arch (HP:0012303)3.04843807
25Abnormality of endocrine pancreas physiology (HP:0012093)3.04744880
26Abnormality of the pancreatic islet cells (HP:0006476)3.04744880
27Gaze-evoked nystagmus (HP:0000640)3.01919176
28Progressive inability to walk (HP:0002505)3.01471869
29Hyperthyroidism (HP:0000836)3.00588132
30Tubular atrophy (HP:0000092)2.94664337
31Pendular nystagmus (HP:0012043)2.89072713
32Abnormality of the ileum (HP:0001549)2.88878624
33Overlapping toe (HP:0001845)2.71423338
34Proximal amyotrophy (HP:0007126)2.70681291
35Spontaneous hematomas (HP:0007420)2.70133490
36Autoimmune hemolytic anemia (HP:0001890)2.66720032
37Type II lissencephaly (HP:0007260)2.60102295
38Broad alveolar ridges (HP:0000187)2.58524591
39Rectal prolapse (HP:0002035)2.54414074
40Severe visual impairment (HP:0001141)2.51413725
41Oligodontia (HP:0000677)2.51000224
42Decreased circulating renin level (HP:0003351)2.48582369
43Abnormality of the renal cortex (HP:0011035)2.39965837
44Abnormality of aromatic amino acid family metabolism (HP:0004338)2.37308285
45Abnormality of macular pigmentation (HP:0008002)2.32246137
46Colon cancer (HP:0003003)2.31431232
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30970258
48Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.28894267
49Central scotoma (HP:0000603)2.28661890
50Potter facies (HP:0002009)2.28577029
51Facial shape deformation (HP:0011334)2.28577029
52Hypoplastic iliac wings (HP:0002866)2.27177002
53Lack of skin elasticity (HP:0100679)2.26324284
54Broad ribs (HP:0000885)2.22287023
55Erythroderma (HP:0001019)2.21952482
56Enlarged kidneys (HP:0000105)2.21298346
57Mesangial abnormality (HP:0001966)2.19089984
58Gangrene (HP:0100758)2.18901153
59Nephroblastoma (Wilms tumor) (HP:0002667)2.16086720
60Birth length less than 3rd percentile (HP:0003561)2.15786285
61Attenuation of retinal blood vessels (HP:0007843)2.14502767
62Vertebral arch anomaly (HP:0008438)2.10612701
63Hypoplasia of the pons (HP:0012110)2.08453300
64Embryonal renal neoplasm (HP:0011794)2.07659242
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.07403645
66Congenital stationary night blindness (HP:0007642)2.07162545
67Duplicated collecting system (HP:0000081)2.05185408
68Thickened helices (HP:0000391)2.03789821
69Scapular winging (HP:0003691)1.98123628
70Agitation (HP:0000713)1.95379874
71Esophageal varix (HP:0002040)1.93987365
72Synostosis of carpal bones (HP:0005048)1.91774958
73Dehydration (HP:0001944)1.89481392
74Abnormality of the pons (HP:0007361)1.89325715
75Scotoma (HP:0000575)1.87878042
76Hematochezia (HP:0002573)1.87723682
77Inability to walk (HP:0002540)1.84924667
78Nonprogressive disorder (HP:0003680)1.83157246
79Abnormality of the renal collecting system (HP:0004742)1.82515774
80Hydroxyprolinuria (HP:0003080)1.79388233
81Abnormality of proline metabolism (HP:0010907)1.79388233
82Gastrointestinal atresia (HP:0002589)1.76995277
83Conjunctival telangiectasia (HP:0000524)1.75881223
84Ulnar claw (HP:0001178)1.71638508
85Retinitis pigmentosa (HP:0000510)1.71621019
86Neonatal respiratory distress (HP:0002643)1.71138752
87Abnormality of the vocal cords (HP:0008777)1.70457948
88Cystic liver disease (HP:0006706)1.70285280
89Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69859848
90Abnormality of the renal medulla (HP:0100957)1.67824874
91Bony spicule pigmentary retinopathy (HP:0007737)1.66595133
92Non-midline cleft lip (HP:0100335)1.64602471
93Bilateral sensorineural hearing impairment (HP:0008619)1.64378584
94Poikiloderma (HP:0001029)1.63284939
95Dysmetric saccades (HP:0000641)1.61468335
96Ectropion (HP:0000656)1.61163430
97Tarsal synostosis (HP:0008368)1.60192226
98Horizontal nystagmus (HP:0000666)1.59946140
99Pancytopenia (HP:0001876)1.59738210
100Photophobia (HP:0000613)1.58293170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS19.37378100
2STK38L5.90305122
3LATS25.52375179
4FRK4.58714358
5ADRBK24.28100868
6ACVR1B2.87871293
7ZAK2.64642942
8STK32.48206202
9STK382.34152590
10PRKD32.11628810
11IRAK32.07320837
12PINK11.94835211
13MAP2K21.90659717
14MELK1.72072845
15NLK1.62936599
16BMPR1B1.62303571
17NEK21.52081122
18ERN11.39844884
19ADRBK11.36688957
20KSR21.35760944
21MAP3K21.32575903
22PIK3CG1.22685327
23TGFBR11.21938277
24TTK1.19923090
25EIF2AK31.18754928
26PRKAA20.90704882
27NME10.85935078
28PDPK10.84107044
29TAOK30.69944428
30GRK70.67214136
31EEF2K0.67074700
32MAP2K10.65225786
33CLK10.63655943
34RIPK40.61855423
35NEK90.60494093
36NTRK30.59292414
37PRKCG0.57589182
38IRAK10.55914309
39CHEK20.52024639
40TEC0.49877806
41PRKCE0.44201511
42NEK10.40096054
43MAPK110.39382983
44WNK40.39085837
45CSNK1A1L0.36058163
46STK100.35629760
47MAP3K80.35568772
48DAPK20.34812667
49PRKD10.34330407
50MAPKAPK50.34076204
51PRKCI0.33070144
52EIF2AK20.32982259
53MKNK10.32509962
54PIM10.32126483
55GRK50.30935814
56PBK0.30739389
57INSRR0.30571286
58TYRO30.30541070
59MOS0.30499375
60GRK10.29325872
61ATR0.25962205
62TAF10.25311591
63MAPK30.24931716
64MAP3K70.24572090
65PLK10.24385790
66PLK40.23658819
67BMX0.22290060
68PLK20.22262269
69MAPK10.22246708
70CAMK2A0.21696216
71TXK0.20798448
72CDC70.19709358
73TRPM70.18909127
74DYRK30.18870844
75TGFBR20.18235041
76PDK20.17882755
77BMPR20.17773693
78EIF2AK10.17383613
79WEE10.16887858
80PRKCB0.15729730
81JAK20.15017269
82PRKG20.13550670
83AKT10.12576125
84MKNK20.12224575
85ATM0.11546169
86BRSK20.11431161
87CDK10.11103667
88ABL10.10806393
89GSK3B0.10315085
90CDK20.09518697
91CSNK1D0.09198867
92PTK2B0.09162064
93NUAK10.09011232
94WNK30.08605750
95MAPKAPK30.07713417
96TNK20.07403109
97PNCK0.07371685
98PLK30.06933206
99RPS6KA30.06692256
100PRKACA0.06549150

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.14643937
2Phototransduction_Homo sapiens_hsa047444.18071752
3Sphingolipid metabolism_Homo sapiens_hsa006004.03356207
4Dorso-ventral axis formation_Homo sapiens_hsa043203.72492379
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.50368051
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.74586506
7Nicotine addiction_Homo sapiens_hsa050332.28917579
8Taste transduction_Homo sapiens_hsa047422.20519438
9Morphine addiction_Homo sapiens_hsa050322.16743382
10Olfactory transduction_Homo sapiens_hsa047402.05100604
11One carbon pool by folate_Homo sapiens_hsa006702.04346287
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.02650255
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.01375507
14ABC transporters_Homo sapiens_hsa020101.98416302
15Butanoate metabolism_Homo sapiens_hsa006501.78605524
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76936475
17Tryptophan metabolism_Homo sapiens_hsa003801.62570556
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60707956
19N-Glycan biosynthesis_Homo sapiens_hsa005101.58060350
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55672396
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.52751461
22Fanconi anemia pathway_Homo sapiens_hsa034601.51252073
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.47892708
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46376038
25Homologous recombination_Homo sapiens_hsa034401.46354323
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41086896
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.33766205
28Basal transcription factors_Homo sapiens_hsa030221.30933339
29Ovarian steroidogenesis_Homo sapiens_hsa049131.25266939
30Glycerolipid metabolism_Homo sapiens_hsa005611.23068045
31Calcium signaling pathway_Homo sapiens_hsa040201.21195160
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09032635
33Nitrogen metabolism_Homo sapiens_hsa009101.06994763
34Histidine metabolism_Homo sapiens_hsa003401.04918357
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00245372
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99806568
37Phenylalanine metabolism_Homo sapiens_hsa003600.94451951
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92026573
39GABAergic synapse_Homo sapiens_hsa047270.90444687
40Sphingolipid signaling pathway_Homo sapiens_hsa040710.90052969
41Glycosaminoglycan degradation_Homo sapiens_hsa005310.88898218
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87059639
43Linoleic acid metabolism_Homo sapiens_hsa005910.83831416
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80741314
45Serotonergic synapse_Homo sapiens_hsa047260.79374186
46Pyruvate metabolism_Homo sapiens_hsa006200.76540911
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76468814
48Fatty acid degradation_Homo sapiens_hsa000710.75491725
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73870722
50Sulfur relay system_Homo sapiens_hsa041220.71315958
51VEGF signaling pathway_Homo sapiens_hsa043700.69759490
52Retinol metabolism_Homo sapiens_hsa008300.67528887
53Selenocompound metabolism_Homo sapiens_hsa004500.64407322
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63363166
55Arachidonic acid metabolism_Homo sapiens_hsa005900.62699964
56Glutamatergic synapse_Homo sapiens_hsa047240.62500411
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62002042
58Vitamin digestion and absorption_Homo sapiens_hsa049770.61811970
59Salivary secretion_Homo sapiens_hsa049700.59049644
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58952461
61Cell cycle_Homo sapiens_hsa041100.58926904
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55988334
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54517704
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49947281
65Glutathione metabolism_Homo sapiens_hsa004800.49506746
66Starch and sucrose metabolism_Homo sapiens_hsa005000.47754942
67Estrogen signaling pathway_Homo sapiens_hsa049150.43809432
68Metabolic pathways_Homo sapiens_hsa011000.41653689
69beta-Alanine metabolism_Homo sapiens_hsa004100.38904874
70Pentose phosphate pathway_Homo sapiens_hsa000300.38857292
71Lysine degradation_Homo sapiens_hsa003100.38837240
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36787477
73Bile secretion_Homo sapiens_hsa049760.36715794
74Propanoate metabolism_Homo sapiens_hsa006400.36538723
75ECM-receptor interaction_Homo sapiens_hsa045120.34840699
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32473317
77Tyrosine metabolism_Homo sapiens_hsa003500.31818112
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.31137124
79Fatty acid biosynthesis_Homo sapiens_hsa000610.30312850
80Arginine and proline metabolism_Homo sapiens_hsa003300.30209535
81Purine metabolism_Homo sapiens_hsa002300.29476989
82Circadian entrainment_Homo sapiens_hsa047130.28475470
83Chemical carcinogenesis_Homo sapiens_hsa052040.28366333
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27016086
85Biosynthesis of amino acids_Homo sapiens_hsa012300.26436092
86cAMP signaling pathway_Homo sapiens_hsa040240.25805782
87Dilated cardiomyopathy_Homo sapiens_hsa054140.25093948
88Ether lipid metabolism_Homo sapiens_hsa005650.24316097
89MicroRNAs in cancer_Homo sapiens_hsa052060.24195156
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22472331
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21734567
92Thyroid cancer_Homo sapiens_hsa052160.21684463
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20625826
94African trypanosomiasis_Homo sapiens_hsa051430.20436197
95Long-term depression_Homo sapiens_hsa047300.19207915
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.19111667
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18652357
98TGF-beta signaling pathway_Homo sapiens_hsa043500.18039081
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17021845
100Complement and coagulation cascades_Homo sapiens_hsa046100.15451700

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