ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of protein glycosylation (GO:0060049)	8.54322731
2	negative regulation of cytosolic calcium ion concentration (GO:0051481)	8.31363650
3	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.64448844
4	piRNA metabolic process (GO:0034587)	7.56380802
5	DNA methylation involved in gamete generation (GO:0043046)	7.47442973
6	regulation of translational termination (GO:0006449)	7.40625872
7	lipopolysaccharide biosynthetic process (GO:0009103)	6.75750983
8	negative regulation of cAMP-mediated signaling (GO:0043951)	6.72884414
9	notochord development (GO:0030903)	6.58873373
10	protein-chromophore linkage (GO:0018298)	6.44907737
11	opioid receptor signaling pathway (GO:0038003)	6.43856669
12	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	6.37398224
13	regulation of meiosis I (GO:0060631)	6.25171845
14	lipopolysaccharide metabolic process (GO:0008653)	5.82047132
15	behavioral response to ethanol (GO:0048149)	5.81562613
16	negative regulation of glycoprotein metabolic process (GO:1903019)	5.53392921
17	ether lipid metabolic process (GO:0046485)	5.45836687
18	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	5.34932813
19	adult feeding behavior (GO:0008343)	5.26653123
20	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	5.25437165
21	sulfate transmembrane transport (GO:1902358)	5.11496448
22	ribonucleoprotein complex disassembly (GO:0032988)	4.89879010
23	regulation of pigment cell differentiation (GO:0050932)	4.78404947
24	positive regulation of developmental pigmentation (GO:0048087)	4.72386828
25	positive regulation of cAMP-mediated signaling (GO:0043950)	4.69835370
26	negative regulation of cell cycle G2/M phase transition (GO:1902750)	4.64349402
27	sulfate transport (GO:0008272)	4.62571784
28	meiotic chromosome segregation (GO:0045132)	4.52418531
29	regulation of acrosome reaction (GO:0060046)	4.42611318
30	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	4.42042859
31	negative regulation of cell-matrix adhesion (GO:0001953)	4.25368810
32	regulation of odontogenesis (GO:0042481)	4.19489783
33	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.16865678
34	heme transport (GO:0015886)	4.07827436
35	paraxial mesoderm development (GO:0048339)	4.06384837
36	rhodopsin mediated signaling pathway (GO:0016056)	3.82198389
37	serotonin receptor signaling pathway (GO:0007210)	3.75276286
38	centriole replication (GO:0007099)	3.73171803
39	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.72968321
40	tyrosine metabolic process (GO:0006570)	3.67959783
41	thrombin receptor signaling pathway (GO:0070493)	3.65782866
42	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.61649843
43	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.61596567
44	L-phenylalanine catabolic process (GO:0006559)	3.61596567
45	nodal signaling pathway (GO:0038092)	3.60461033
46	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.51060942
47	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	3.50072826
48	tachykinin receptor signaling pathway (GO:0007217)	3.49311018
49	gene silencing by RNA (GO:0031047)	3.43520006
50	DNA damage induced protein phosphorylation (GO:0006975)	3.42032416
51	polyol biosynthetic process (GO:0046173)	3.36791627
52	indolalkylamine metabolic process (GO:0006586)	3.34202806
53	negative regulation of nitric oxide biosynthetic process (GO:0045019)	3.29875811
54	regulation of glutamate receptor signaling pathway (GO:1900449)	3.20616460
55	positive regulation of meiosis (GO:0045836)	3.20146738
56	urate metabolic process (GO:0046415)	3.19624122
57	SMAD protein complex assembly (GO:0007183)	3.14829172
58	meiotic cell cycle (GO:0051321)	3.13858193
59	L-phenylalanine metabolic process (GO:0006558)	3.09528395
60	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.09528395
61	dicarboxylic acid catabolic process (GO:0043649)	3.07662180
62	DNA replication-dependent nucleosome assembly (GO:0006335)	3.07325454
63	DNA replication-dependent nucleosome organization (GO:0034723)	3.07325454
64	aromatic amino acid family catabolic process (GO:0009074)	3.03346430
65	DNA alkylation (GO:0006305)	2.99575927
66	DNA methylation (GO:0006306)	2.99575927
67	flavonoid metabolic process (GO:0009812)	2.98362460
68	organelle disassembly (GO:1903008)	2.97663557
69	positive regulation of meiotic cell cycle (GO:0051446)	2.95854604
70	aspartate family amino acid catabolic process (GO:0009068)	2.93816155
71	cellular response to ammonium ion (GO:0071242)	2.85296283
72	cellular response to alkaloid (GO:0071312)	2.81410419
73	glycerol ether metabolic process (GO:0006662)	2.81278626
74	sphingolipid biosynthetic process (GO:0030148)	2.79280783
75	aromatic amino acid family metabolic process (GO:0009072)	2.78647085
76	iron coordination entity transport (GO:1901678)	2.77164660
77	glycerol metabolic process (GO:0006071)	2.76989242
78	sulfur compound transport (GO:0072348)	2.76511609
79	regulation of cAMP-mediated signaling (GO:0043949)	2.76173646
80	regulation of translational elongation (GO:0006448)	2.75998786
81	vitamin transmembrane transport (GO:0035461)	2.74851199
82	germinal center formation (GO:0002467)	2.74193743
83	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.73976206
84	thyroid hormone metabolic process (GO:0042403)	2.71063301
85	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.67042812
86	membrane lipid biosynthetic process (GO:0046467)	2.65634397
87	inner cell mass cell proliferation (GO:0001833)	2.62963356
88	spermatid development (GO:0007286)	2.62744712
89	thyroid hormone generation (GO:0006590)	2.60508446
90	adaptation of signaling pathway (GO:0023058)	2.60193958
91	regulation of glycoprotein biosynthetic process (GO:0010559)	2.59853155
92	tetrahydrofolate metabolic process (GO:0046653)	2.59751495
93	left/right axis specification (GO:0070986)	2.59598146
94	biotin metabolic process (GO:0006768)	2.59427005
95	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.58304106
96	ether metabolic process (GO:0018904)	2.56184174
97	reciprocal DNA recombination (GO:0035825)	2.55321682
98	sphingosine metabolic process (GO:0006670)	15.2420126
99	diol metabolic process (GO:0034311)	13.7303322
100	sphingoid metabolic process (GO:0046519)	12.8011273

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	4.64693213
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.01566181
3	AR_21572438_ChIP-Seq_LNCaP_Human	3.96384564
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.41607030
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.34684422
6	VDR_22108803_ChIP-Seq_LS180_Human	3.33844014
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.62808750
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.62499931
9	EGR1_19032775_ChIP-ChIP_M12_Human	2.57633316
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.41833684
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32978958
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31134933
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.31134933
14	NANOG_19829295_ChIP-Seq_ESCs_Human	2.11419400
15	SOX2_19829295_ChIP-Seq_ESCs_Human	2.11419400
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.06073222
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.99512418
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.88250941
19	TCF4_23295773_ChIP-Seq_U87_Human	1.85653561
20	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.84306920
21	EZH2_22144423_ChIP-Seq_EOC_Human	1.82656793
22	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.81048478
23	SCL_19346495_ChIP-Seq_HPC-7_Human	1.80318242
24	STAT3_23295773_ChIP-Seq_U87_Human	1.77361029
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.76421638
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75289118
27	P300_19829295_ChIP-Seq_ESCs_Human	1.69483550
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.67192232
29	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.65628727
30	STAT1_20625510_ChIP-Seq_HELA_Human	1.64788938
31	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.63826106
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58770376
33	HOXB7_26014856_ChIP-Seq_BT474_Human	1.55299603
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49806372
35	RXR_22108803_ChIP-Seq_LS180_Human	1.49088887
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.47987395
37	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.45020467
38	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.44957503
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39463323
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.38382412
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38382412
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.37905714
43	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.36399179
44	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.33077362
45	OCT4_20526341_ChIP-Seq_ESCs_Human	1.32680733
46	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.32461496
47	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.32396488
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32011435
49	CEBPB_22108803_ChIP-Seq_LS180_Human	1.31440350
50	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30708302
51	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.28278406
52	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.28275206
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.27528244
54	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26753032
55	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.24737123
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.23708997
57	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23621177
58	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.22948243
59	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.21964927
60	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21824493
61	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.21485860
62	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.20978244
63	CDX2_22108803_ChIP-Seq_LS180_Human	1.20580124
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18328598
65	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.16908056
66	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16083918
67	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15327103
68	NCOR_22424771_ChIP-Seq_293T_Human	1.15130980
69	AR_25329375_ChIP-Seq_VCAP_Human	1.14366297
70	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.13943275
71	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13400026
72	TP53_16413492_ChIP-PET_HCT116_Human	1.12491572
73	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11329469
74	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11315640
75	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10918412
76	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.10461991
77	P53_21459846_ChIP-Seq_SAOS-2_Human	1.10071408
78	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09364500
79	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.08513637
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08042428
81	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.07367067
82	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04520379
83	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04484104
84	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.03891125
85	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.03051848
86	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02085289
87	GATA1_19941826_ChIP-Seq_K562_Human	1.01811062
88	TP53_22573176_ChIP-Seq_HFKS_Human	1.00758453
89	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.00279836
90	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99698639
91	AR_19668381_ChIP-Seq_PC3_Human	0.97724607
92	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96228487
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.95924547
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.95924547
95	GATA3_26560356_Chip-Seq_TH1_Human	0.93133953
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.92772563
97	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.92430721
98	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.92365138
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.92115680
100	BCAT_22108803_ChIP-Seq_LS180_Human	0.91531168

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	7.32983420
2	MP0003136_yellow_coat_color	6.50783501
3	MP0005171_absent_coat_pigmentation	6.03150534
4	MP0003045_fibrosis	4.71309252
5	MP0002653_abnormal_ependyma_morphology	4.65194324
6	MP0003646_muscle_fatigue	4.14008361
7	MP0003890_abnormal_embryonic-extraembry	3.83413204
8	MP0003879_abnormal_hair_cell	3.48369529
9	MP0009278_abnormal_bone_marrow	3.05379612
10	MP0004147_increased_porphyrin_level	2.87074253
11	MP0002876_abnormal_thyroid_physiology	2.71671477
12	MP0000569_abnormal_digit_pigmentation	2.69996656
13	MP0005670_abnormal_white_adipose	2.39590736
14	MP0004381_abnormal_hair_follicle	2.10311147
15	MP0002138_abnormal_hepatobiliary_system	2.03299670
16	MP0003195_calcinosis	2.00045599
17	MP0005085_abnormal_gallbladder_physiolo	1.91277498
18	MP0000749_muscle_degeneration	1.90984818
19	MP0005360_urolithiasis	1.90653907
20	MP0002168_other_aberrant_phenotype	1.84870945
21	MP0003950_abnormal_plasma_membrane	1.79967569
22	MP0009780_abnormal_chondrocyte_physiolo	1.69586643
23	MP0008057_abnormal_DNA_replication	1.68297596
24	MP0000678_abnormal_parathyroid_gland	1.65623618
25	MP0001501_abnormal_sleep_pattern	1.63863753
26	MP0001968_abnormal_touch/_nociception	1.63677055
27	MP0004233_abnormal_muscle_weight	1.53017922
28	MP0005503_abnormal_tendon_morphology	1.47622290
29	MP0009764_decreased_sensitivity_to	1.33291648
30	MP0002938_white_spotting	1.33097701
31	MP0002095_abnormal_skin_pigmentation	1.31561657
32	MP0005395_other_phenotype	1.23835125
33	MP0000015_abnormal_ear_pigmentation	1.20868927
34	MP0003705_abnormal_hypodermis_morpholog	1.15659998
35	MP0003183_abnormal_peptide_metabolism	1.15568736
36	MP0005551_abnormal_eye_electrophysiolog	1.15515322
37	MP0005075_abnormal_melanosome_morpholog	1.14519803
38	MP0004043_abnormal_pH_regulation	1.14152461
39	MP0001545_abnormal_hematopoietic_system	1.14136484
40	MP0005397_hematopoietic_system_phenotyp	1.14136484
41	MP0005646_abnormal_pituitary_gland	1.10286490
42	MP0003941_abnormal_skin_development	1.10038986
43	MP0006035_abnormal_mitochondrial_morpho	1.09900162
44	MP0003959_abnormal_lean_body	1.09761139
45	MP0000681_abnormal_thyroid_gland	1.06623682
46	MP0010352_gastrointestinal_tract_polyps	1.02667374
47	MP0002971_abnormal_brown_adipose	0.98598281
48	MP0005365_abnormal_bile_salt	0.95888137
49	MP0001664_abnormal_digestion	0.92725841
50	MP0002160_abnormal_reproductive_system	0.90576566
51	MP0009046_muscle_twitch	0.85585717
52	MP0002269_muscular_atrophy	0.78826901
53	MP0002075_abnormal_coat/hair_pigmentati	0.77724421
54	MP0001486_abnormal_startle_reflex	0.77034094
55	MP0002733_abnormal_thermal_nociception	0.76026521
56	MP0009745_abnormal_behavioral_response	0.73067993
57	MP0005174_abnormal_tail_pigmentation	0.72584743
58	MP0002272_abnormal_nervous_system	0.72142336
59	MP0004130_abnormal_muscle_cell	0.71455281
60	MP0003937_abnormal_limbs/digits/tail_de	0.69873408
61	MP0005377_hearing/vestibular/ear_phenot	0.66186171
62	MP0003878_abnormal_ear_physiology	0.66186171
63	MP0006054_spinal_hemorrhage	0.64592318
64	MP0008872_abnormal_physiological_respon	0.64286919
65	MP0001661_extended_life_span	0.62430802
66	MP0000427_abnormal_hair_cycle	0.62339125
67	MP0001970_abnormal_pain_threshold	0.61822141
68	MP0003718_maternal_effect	0.61304858
69	MP0010094_abnormal_chromosome_stability	0.60202874
70	MP0005389_reproductive_system_phenotype	0.59511234
71	MP0003137_abnormal_impulse_conducting	0.59286225
72	MP0005330_cardiomyopathy	0.58823605
73	MP0008770_decreased_survivor_rate	0.58038790
74	MP0003252_abnormal_bile_duct	0.57978995
75	MP0001324_abnormal_eye_pigmentation	0.57517995
76	MP0000230_abnormal_systemic_arterial	0.56317130
77	MP0002735_abnormal_chemical_nociception	0.55592242
78	MP0002229_neurodegeneration	0.54825029
79	MP0002102_abnormal_ear_morphology	0.54771186
80	MP0009333_abnormal_splenocyte_physiolog	0.53877730
81	MP0004957_abnormal_blastocyst_morpholog	0.53430319
82	MP0005410_abnormal_fertilization	0.53214205
83	MP0008874_decreased_physiological_sensi	0.51670670
84	MP0003698_abnormal_male_reproductive	0.50726027
85	MP0001929_abnormal_gametogenesis	0.49965982
86	MP0003638_abnormal_response/metabolism_	0.49962056
87	MP0002210_abnormal_sex_determination	0.49024531
88	MP0005319_abnormal_enzyme/_coenzyme	0.47343607
89	MP0002396_abnormal_hematopoietic_system	0.46974378
90	MP0010307_abnormal_tumor_latency	0.45738362
91	MP0003633_abnormal_nervous_system	0.45179702
92	MP0001986_abnormal_taste_sensitivity	0.44793507
93	MP0008058_abnormal_DNA_repair	0.40847549
94	MP0002254_reproductive_system_inflammat	0.40639337
95	MP0000358_abnormal_cell_content/	0.40407713
96	MP0006276_abnormal_autonomic_nervous	0.40330566
97	MP0001186_pigmentation_phenotype	0.40260645
98	MP0006036_abnormal_mitochondrial_physio	0.37603260
99	MP0001881_abnormal_mammary_gland	0.36869768
100	MP0005266_abnormal_metabolism	0.36646382

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	8.18654848
2	Thyroid-stimulating hormone excess (HP:0002925)	8.03235518
3	Amelogenesis imperfecta (HP:0000705)	7.86744228
4	Acanthocytosis (HP:0001927)	5.56901478
5	Congenital ichthyosiform erythroderma (HP:0007431)	5.03891277
6	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.71475506
7	Parakeratosis (HP:0001036)	4.65677787
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.60485556
9	Dialeptic seizures (HP:0011146)	4.48607149
10	Aplastic anemia (HP:0001915)	4.39752037
11	Chromsome breakage (HP:0040012)	4.25345594
12	Volvulus (HP:0002580)	4.22266737
13	Pancreatic islet-cell hyperplasia (HP:0004510)	4.17778329
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.06431432
15	Ileus (HP:0002595)	3.66430539
16	Focal seizures (HP:0007359)	3.56591986
17	Intestinal atresia (HP:0011100)	3.53107968
18	Large for gestational age (HP:0001520)	3.50570500
19	Cerebellar dysplasia (HP:0007033)	3.22127148
20	Poikilocytosis (HP:0004447)	3.21048111
21	Poor head control (HP:0002421)	3.13827732
22	Difficulty walking (HP:0002355)	3.09828489
23	Pancreatic cysts (HP:0001737)	3.09086698
24	Abnormality of the aortic arch (HP:0012303)	3.04843807
25	Abnormality of endocrine pancreas physiology (HP:0012093)	3.04744880
26	Abnormality of the pancreatic islet cells (HP:0006476)	3.04744880
27	Gaze-evoked nystagmus (HP:0000640)	3.01919176
28	Progressive inability to walk (HP:0002505)	3.01471869
29	Hyperthyroidism (HP:0000836)	3.00588132
30	Tubular atrophy (HP:0000092)	2.94664337
31	Pendular nystagmus (HP:0012043)	2.89072713
32	Abnormality of the ileum (HP:0001549)	2.88878624
33	Overlapping toe (HP:0001845)	2.71423338
34	Proximal amyotrophy (HP:0007126)	2.70681291
35	Spontaneous hematomas (HP:0007420)	2.70133490
36	Autoimmune hemolytic anemia (HP:0001890)	2.66720032
37	Type II lissencephaly (HP:0007260)	2.60102295
38	Broad alveolar ridges (HP:0000187)	2.58524591
39	Rectal prolapse (HP:0002035)	2.54414074
40	Severe visual impairment (HP:0001141)	2.51413725
41	Oligodontia (HP:0000677)	2.51000224
42	Decreased circulating renin level (HP:0003351)	2.48582369
43	Abnormality of the renal cortex (HP:0011035)	2.39965837
44	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.37308285
45	Abnormality of macular pigmentation (HP:0008002)	2.32246137
46	Colon cancer (HP:0003003)	2.31431232
47	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.30970258
48	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.28894267
49	Central scotoma (HP:0000603)	2.28661890
50	Potter facies (HP:0002009)	2.28577029
51	Facial shape deformation (HP:0011334)	2.28577029
52	Hypoplastic iliac wings (HP:0002866)	2.27177002
53	Lack of skin elasticity (HP:0100679)	2.26324284
54	Broad ribs (HP:0000885)	2.22287023
55	Erythroderma (HP:0001019)	2.21952482
56	Enlarged kidneys (HP:0000105)	2.21298346
57	Mesangial abnormality (HP:0001966)	2.19089984
58	Gangrene (HP:0100758)	2.18901153
59	Nephroblastoma (Wilms tumor) (HP:0002667)	2.16086720
60	Birth length less than 3rd percentile (HP:0003561)	2.15786285
61	Attenuation of retinal blood vessels (HP:0007843)	2.14502767
62	Vertebral arch anomaly (HP:0008438)	2.10612701
63	Hypoplasia of the pons (HP:0012110)	2.08453300
64	Embryonal renal neoplasm (HP:0011794)	2.07659242
65	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.07403645
66	Congenital stationary night blindness (HP:0007642)	2.07162545
67	Duplicated collecting system (HP:0000081)	2.05185408
68	Thickened helices (HP:0000391)	2.03789821
69	Scapular winging (HP:0003691)	1.98123628
70	Agitation (HP:0000713)	1.95379874
71	Esophageal varix (HP:0002040)	1.93987365
72	Synostosis of carpal bones (HP:0005048)	1.91774958
73	Dehydration (HP:0001944)	1.89481392
74	Abnormality of the pons (HP:0007361)	1.89325715
75	Scotoma (HP:0000575)	1.87878042
76	Hematochezia (HP:0002573)	1.87723682
77	Inability to walk (HP:0002540)	1.84924667
78	Nonprogressive disorder (HP:0003680)	1.83157246
79	Abnormality of the renal collecting system (HP:0004742)	1.82515774
80	Hydroxyprolinuria (HP:0003080)	1.79388233
81	Abnormality of proline metabolism (HP:0010907)	1.79388233
82	Gastrointestinal atresia (HP:0002589)	1.76995277
83	Conjunctival telangiectasia (HP:0000524)	1.75881223
84	Ulnar claw (HP:0001178)	1.71638508
85	Retinitis pigmentosa (HP:0000510)	1.71621019
86	Neonatal respiratory distress (HP:0002643)	1.71138752
87	Abnormality of the vocal cords (HP:0008777)	1.70457948
88	Cystic liver disease (HP:0006706)	1.70285280
89	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.69859848
90	Abnormality of the renal medulla (HP:0100957)	1.67824874
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.66595133
92	Non-midline cleft lip (HP:0100335)	1.64602471
93	Bilateral sensorineural hearing impairment (HP:0008619)	1.64378584
94	Poikiloderma (HP:0001029)	1.63284939
95	Dysmetric saccades (HP:0000641)	1.61468335
96	Ectropion (HP:0000656)	1.61163430
97	Tarsal synostosis (HP:0008368)	1.60192226
98	Horizontal nystagmus (HP:0000666)	1.59946140
99	Pancytopenia (HP:0001876)	1.59738210
100	Photophobia (HP:0000613)	1.58293170

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	9.37378100
2	STK38L	5.90305122
3	LATS2	5.52375179
4	FRK	4.58714358
5	ADRBK2	4.28100868
6	ACVR1B	2.87871293
7	ZAK	2.64642942
8	STK3	2.48206202
9	STK38	2.34152590
10	PRKD3	2.11628810
11	IRAK3	2.07320837
12	PINK1	1.94835211
13	MAP2K2	1.90659717
14	MELK	1.72072845
15	NLK	1.62936599
16	BMPR1B	1.62303571
17	NEK2	1.52081122
18	ERN1	1.39844884
19	ADRBK1	1.36688957
20	KSR2	1.35760944
21	MAP3K2	1.32575903
22	PIK3CG	1.22685327
23	TGFBR1	1.21938277
24	TTK	1.19923090
25	EIF2AK3	1.18754928
26	PRKAA2	0.90704882
27	NME1	0.85935078
28	PDPK1	0.84107044
29	TAOK3	0.69944428
30	GRK7	0.67214136
31	EEF2K	0.67074700
32	MAP2K1	0.65225786
33	CLK1	0.63655943
34	RIPK4	0.61855423
35	NEK9	0.60494093
36	NTRK3	0.59292414
37	PRKCG	0.57589182
38	IRAK1	0.55914309
39	CHEK2	0.52024639
40	TEC	0.49877806
41	PRKCE	0.44201511
42	NEK1	0.40096054
43	MAPK11	0.39382983
44	WNK4	0.39085837
45	CSNK1A1L	0.36058163
46	STK10	0.35629760
47	MAP3K8	0.35568772
48	DAPK2	0.34812667
49	PRKD1	0.34330407
50	MAPKAPK5	0.34076204
51	PRKCI	0.33070144
52	EIF2AK2	0.32982259
53	MKNK1	0.32509962
54	PIM1	0.32126483
55	GRK5	0.30935814
56	PBK	0.30739389
57	INSRR	0.30571286
58	TYRO3	0.30541070
59	MOS	0.30499375
60	GRK1	0.29325872
61	ATR	0.25962205
62	TAF1	0.25311591
63	MAPK3	0.24931716
64	MAP3K7	0.24572090
65	PLK1	0.24385790
66	PLK4	0.23658819
67	BMX	0.22290060
68	PLK2	0.22262269
69	MAPK1	0.22246708
70	CAMK2A	0.21696216
71	TXK	0.20798448
72	CDC7	0.19709358
73	TRPM7	0.18909127
74	DYRK3	0.18870844
75	TGFBR2	0.18235041
76	PDK2	0.17882755
77	BMPR2	0.17773693
78	EIF2AK1	0.17383613
79	WEE1	0.16887858
80	PRKCB	0.15729730
81	JAK2	0.15017269
82	PRKG2	0.13550670
83	AKT1	0.12576125
84	MKNK2	0.12224575
85	ATM	0.11546169
86	BRSK2	0.11431161
87	CDK1	0.11103667
88	ABL1	0.10806393
89	GSK3B	0.10315085
90	CDK2	0.09518697
91	CSNK1D	0.09198867
92	PTK2B	0.09162064
93	NUAK1	0.09011232
94	WNK3	0.08605750
95	MAPKAPK3	0.07713417
96	TNK2	0.07403109
97	PNCK	0.07371685
98	PLK3	0.06933206
99	RPS6KA3	0.06692256
100	PRKACA	0.06549150

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	6.14643937
2	Phototransduction_Homo sapiens_hsa04744	4.18071752
3	Sphingolipid metabolism_Homo sapiens_hsa00600	4.03356207
4	Dorso-ventral axis formation_Homo sapiens_hsa04320	3.72492379
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.50368051
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.74586506
7	Nicotine addiction_Homo sapiens_hsa05033	2.28917579
8	Taste transduction_Homo sapiens_hsa04742	2.20519438
9	Morphine addiction_Homo sapiens_hsa05032	2.16743382
10	Olfactory transduction_Homo sapiens_hsa04740	2.05100604
11	One carbon pool by folate_Homo sapiens_hsa00670	2.04346287
12	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.02650255
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.01375507
14	ABC transporters_Homo sapiens_hsa02010	1.98416302
15	Butanoate metabolism_Homo sapiens_hsa00650	1.78605524
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76936475
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.62570556
18	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.60707956
19	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.58060350
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55672396
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.52751461
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51252073
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.47892708
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.46376038
25	Homologous recombination_Homo sapiens_hsa03440	1.46354323
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.41086896
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.33766205
28	Basal transcription factors_Homo sapiens_hsa03022	1.30933339
29	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.25266939
30	Glycerolipid metabolism_Homo sapiens_hsa00561	1.23068045
31	Calcium signaling pathway_Homo sapiens_hsa04020	1.21195160
32	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.09032635
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.06994763
34	Histidine metabolism_Homo sapiens_hsa00340	1.04918357
35	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.00245372
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99806568
37	Phenylalanine metabolism_Homo sapiens_hsa00360	0.94451951
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.92026573
39	GABAergic synapse_Homo sapiens_hsa04727	0.90444687
40	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.90052969
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.88898218
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87059639
43	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83831416
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80741314
45	Serotonergic synapse_Homo sapiens_hsa04726	0.79374186
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.76540911
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.76468814
48	Fatty acid degradation_Homo sapiens_hsa00071	0.75491725
49	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73870722
50	Sulfur relay system_Homo sapiens_hsa04122	0.71315958
51	VEGF signaling pathway_Homo sapiens_hsa04370	0.69759490
52	Retinol metabolism_Homo sapiens_hsa00830	0.67528887
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.64407322
54	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.63363166
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62699964
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.62500411
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.62002042
58	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61811970
59	Salivary secretion_Homo sapiens_hsa04970	0.59049644
60	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.58952461
61	Cell cycle_Homo sapiens_hsa04110	0.58926904
62	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.55988334
63	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.54517704
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49947281
65	Glutathione metabolism_Homo sapiens_hsa00480	0.49506746
66	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47754942
67	Estrogen signaling pathway_Homo sapiens_hsa04915	0.43809432
68	Metabolic pathways_Homo sapiens_hsa01100	0.41653689
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38904874
70	Pentose phosphate pathway_Homo sapiens_hsa00030	0.38857292
71	Lysine degradation_Homo sapiens_hsa00310	0.38837240
72	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36787477
73	Bile secretion_Homo sapiens_hsa04976	0.36715794
74	Propanoate metabolism_Homo sapiens_hsa00640	0.36538723
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.34840699
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32473317
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.31818112
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31137124
79	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.30312850
80	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30209535
81	Purine metabolism_Homo sapiens_hsa00230	0.29476989
82	Circadian entrainment_Homo sapiens_hsa04713	0.28475470
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28366333
84	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.27016086
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.26436092
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.25805782
87	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.25093948
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.24316097
89	MicroRNAs in cancer_Homo sapiens_hsa05206	0.24195156
90	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.22472331
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21734567
92	Thyroid cancer_Homo sapiens_hsa05216	0.21684463
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.20625826
94	African trypanosomiasis_Homo sapiens_hsa05143	0.20436197
95	Long-term depression_Homo sapiens_hsa04730	0.19207915
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19111667
97	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.18652357
98	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.18039081
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.17021845
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.15451700

SSX6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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