SSXP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1forebrain neuron differentiation (GO:0021879)6.54582860
2C21-steroid hormone biosynthetic process (GO:0006700)6.40809479
3regulation of timing of cell differentiation (GO:0048505)6.27275845
4regulation of development, heterochronic (GO:0040034)6.24358020
5neuronal stem cell maintenance (GO:0097150)6.01159888
6auditory receptor cell differentiation (GO:0042491)5.81758976
7Notch signaling involved in heart development (GO:0061314)5.71098425
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.49154815
9cilium or flagellum-dependent cell motility (GO:0001539)5.32151006
10axonemal dynein complex assembly (GO:0070286)5.26918029
11positive regulation of Notch signaling pathway (GO:0045747)5.20794045
12myoblast differentiation (GO:0045445)5.20574632
13spinal cord association neuron differentiation (GO:0021527)5.05607005
14progesterone metabolic process (GO:0042448)4.82214836
15hair cell differentiation (GO:0035315)4.80361371
16ganglion development (GO:0061548)4.71969365
17cilium movement (GO:0003341)4.53236465
18epithelial cilium movement (GO:0003351)4.44251409
19olfactory bulb development (GO:0021772)4.27674028
20phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.09792787
21cell fate commitment involved in formation of primary germ layer (GO:0060795)4.01064976
22interkinetic nuclear migration (GO:0022027)3.99471971
23glial cell proliferation (GO:0014009)3.99402967
24cerebral cortex neuron differentiation (GO:0021895)3.99070293
25regulation of sister chromatid cohesion (GO:0007063)3.91112672
26embryonic foregut morphogenesis (GO:0048617)3.81815919
27cell surface receptor signaling pathway involved in heart development (GO:0061311)3.72296174
28nonmotile primary cilium assembly (GO:0035058)3.69761157
29cardiac cell development (GO:0055006)3.65007644
30histone H3-K36 demethylation (GO:0070544)3.58653408
31motile cilium assembly (GO:0044458)3.57048591
32lung secretory cell differentiation (GO:0061140)3.50883120
33negative regulation of oligodendrocyte differentiation (GO:0048715)3.46987201
34regulation of cardioblast differentiation (GO:0051890)3.44146612
35cardiac right ventricle morphogenesis (GO:0003215)3.41734297
36axoneme assembly (GO:0035082)3.40420003
37response to folic acid (GO:0051593)3.32052298
38regulation of secondary heart field cardioblast proliferation (GO:0003266)3.25404631
39regulation of cardioblast proliferation (GO:0003264)3.25404631
40microtubule anchoring (GO:0034453)3.25346216
41C21-steroid hormone metabolic process (GO:0008207)3.22973437
42oocyte development (GO:0048599)3.18441545
43nucleus localization (GO:0051647)3.18400786
44musculoskeletal movement (GO:0050881)3.16088427
45multicellular organismal movement (GO:0050879)3.16088427
46neuron fate commitment (GO:0048663)3.15971572
47regulation of oligodendrocyte differentiation (GO:0048713)3.12978531
48histone H2B ubiquitination (GO:0033523)3.08710575
49N-terminal protein amino acid acetylation (GO:0006474)3.07462575
50positive regulation of endothelial cell differentiation (GO:0045603)3.07035190
51nuclear pore complex assembly (GO:0051292)3.06936936
52forebrain morphogenesis (GO:0048853)3.06894705
53centrosome localization (GO:0051642)3.06195647
54nephron tubule development (GO:0072080)3.05842078
55microtubule depolymerization (GO:0007019)3.05051748
56morphogenesis of an epithelial sheet (GO:0002011)3.01800266
57tongue development (GO:0043586)3.01510586
58positive regulation of oligodendrocyte differentiation (GO:0048714)3.01354963
59positive regulation of neural precursor cell proliferation (GO:2000179)3.00576277
60regulation of pigment cell differentiation (GO:0050932)2.99639257
61phospholipid homeostasis (GO:0055091)2.99620367
62positive regulation of granulocyte differentiation (GO:0030854)2.99600943
63morphogenesis of an endothelium (GO:0003159)2.99583564
64endothelial tube morphogenesis (GO:0061154)2.99583564
65protein destabilization (GO:0031648)2.98616378
66adult heart development (GO:0007512)2.96278866
67renal tubule development (GO:0061326)2.94523835
68neural tube formation (GO:0001841)2.93845910
69potassium ion export (GO:0071435)2.91935269
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.91580360
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91580360
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91580360
73epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89549135
74DNA integration (GO:0015074)2.88244129
75regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.88148596
76pyrimidine dimer repair (GO:0006290)2.86160191
77dentate gyrus development (GO:0021542)2.84347123
78establishment of nucleus localization (GO:0040023)2.83987022
79dosage compensation (GO:0007549)2.81639936
80response to lipoprotein particle (GO:0055094)2.81432855
81pre-miRNA processing (GO:0031054)2.81383197
82histone-serine phosphorylation (GO:0035404)2.81331770
83layer formation in cerebral cortex (GO:0021819)2.81119668
84myofibril assembly (GO:0030239)2.80440130
85regulation of relaxation of muscle (GO:1901077)2.76619524
86genitalia morphogenesis (GO:0035112)2.74640928
87negative regulation of myotube differentiation (GO:0010832)2.74047401
88left/right axis specification (GO:0070986)2.70640225
89embryonic heart tube development (GO:0035050)2.70116236
90mRNA splice site selection (GO:0006376)2.69887017
91fibroblast migration (GO:0010761)2.69254317
92cellular response to ethanol (GO:0071361)2.68830914
93left/right pattern formation (GO:0060972)2.68453422
94histone mRNA catabolic process (GO:0071044)2.66899201
95cilium morphogenesis (GO:0060271)2.65401737
96response to muramyl dipeptide (GO:0032495)2.62962185
97neuroblast proliferation (GO:0007405)2.62957872
98cell fate determination (GO:0001709)2.62819149
99neurogenesis (GO:0022008)2.62117514
100cardiac muscle cell development (GO:0055013)2.61283696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.05386919
2GATA1_22025678_ChIP-Seq_K562_Human3.97326481
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.22523100
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.07503288
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.85528407
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80088295
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.59879561
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47194370
9TP53_16413492_ChIP-PET_HCT116_Human2.45342792
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.41292202
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29782970
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23006814
13SCL_19346495_ChIP-Seq_HPC-7_Human2.20310702
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11860417
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.04253195
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.98275435
17MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76212635
18SMAD4_21799915_ChIP-Seq_A2780_Human1.71810843
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.70650474
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.69166291
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68443794
22SMAD3_21741376_ChIP-Seq_EPCs_Human1.67300848
23TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.67172490
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62666722
25IGF1R_20145208_ChIP-Seq_DFB_Human1.61478479
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61454010
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.57835387
28TP53_18474530_ChIP-ChIP_U2OS_Human1.56865503
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54557894
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54142750
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54142750
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.52899926
33AHR_22903824_ChIP-Seq_MCF-7_Human1.52796500
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50695171
35FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48848682
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48181430
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47168713
38P300_19829295_ChIP-Seq_ESCs_Human1.46390942
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45884377
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.45761086
41FLI1_21867929_ChIP-Seq_TH2_Mouse1.42842783
42AR_21572438_ChIP-Seq_LNCaP_Human1.42815759
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42617890
44EZH2_22144423_ChIP-Seq_EOC_Human1.42508036
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.42337883
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40933247
47STAT3_23295773_ChIP-Seq_U87_Human1.40719811
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.37021645
49RUNX_20019798_ChIP-Seq_JUKART_Human1.36879117
50CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36328330
51CBP_20019798_ChIP-Seq_JUKART_Human1.35850526
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35850526
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.35826065
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33691082
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31406062
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31173787
57TAF15_26573619_Chip-Seq_HEK293_Human1.29621639
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28738140
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28250752
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25422035
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.23631480
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23379018
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21472914
64ER_23166858_ChIP-Seq_MCF-7_Human1.20322603
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17939959
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.17902528
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17849091
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17825914
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17818843
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17818843
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17572006
72TCF4_23295773_ChIP-Seq_U87_Human1.17246085
73TP63_19390658_ChIP-ChIP_HaCaT_Human1.15765278
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15051779
75RUNX2_22187159_ChIP-Seq_PCA_Human1.15010605
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14360040
77TCF4_22108803_ChIP-Seq_LS180_Human1.13739911
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.12755145
79BCAT_22108803_ChIP-Seq_LS180_Human1.10719326
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09898940
81E2F1_18555785_Chip-Seq_ESCs_Mouse1.09576540
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08841178
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08090472
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.07884366
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06345180
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04965918
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03527692
88P53_22387025_ChIP-Seq_ESCs_Mouse1.02657623
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02272604
90WDR5_24793694_ChIP-Seq_LNCAP_Human1.02226548
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02115611
92KDM2B_26808549_Chip-Seq_REH_Human1.01935294
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.01799090
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01764720
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01618736
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00822436
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00709659
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00511826
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99652013
100TP63_23658742_ChIP-Seq_EP156T_Human0.99615996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.05943671
2MP0006054_spinal_hemorrhage3.66651367
3MP0000569_abnormal_digit_pigmentation3.51316608
4MP0006072_abnormal_retinal_apoptosis3.48627151
5MP0008789_abnormal_olfactory_epithelium3.37364685
6MP0005248_abnormal_Harderian_gland2.84172326
7MP0005394_taste/olfaction_phenotype2.82404168
8MP0005499_abnormal_olfactory_system2.82404168
9MP0002009_preneoplasia2.62140886
10MP0001915_intracranial_hemorrhage2.49221981
11MP0005253_abnormal_eye_physiology2.48240846
12MP0008057_abnormal_DNA_replication2.43626178
13MP0003787_abnormal_imprinting2.41042239
14MP0005187_abnormal_penis_morphology2.35595973
15MP0010234_abnormal_vibrissa_follicle2.25561074
16MP0004084_abnormal_cardiac_muscle2.21176892
17MP0005085_abnormal_gallbladder_physiolo2.12577237
18MP0000537_abnormal_urethra_morphology2.04640007
19MP0003646_muscle_fatigue2.02380396
20MP0004036_abnormal_muscle_relaxation1.99110959
21MP0004233_abnormal_muscle_weight1.94146846
22MP0002653_abnormal_ependyma_morphology1.94003518
23MP0000751_myopathy1.93602405
24MP0005647_abnormal_sex_gland1.90516485
25MP0002928_abnormal_bile_duct1.86756179
26MP0003252_abnormal_bile_duct1.81889480
27MP0010368_abnormal_lymphatic_system1.75803142
28MP0003221_abnormal_cardiomyocyte_apopto1.64852655
29MP0000465_gastrointestinal_hemorrhage1.64745519
30MP0005409_darkened_coat_color1.59440538
31MP0005391_vision/eye_phenotype1.59002246
32MP0005167_abnormal_blood-brain_barrier1.57515510
33MP0008877_abnormal_DNA_methylation1.52771765
34MP0000733_abnormal_muscle_development1.48831305
35MP0002127_abnormal_cardiovascular_syste1.37493798
36MP0002092_abnormal_eye_morphology1.37090920
37MP0008004_abnormal_stomach_pH1.36439377
38MP0003984_embryonic_growth_retardation1.33712759
39MP0003121_genomic_imprinting1.28862756
40MP0004484_altered_response_of1.27616761
41MP0004197_abnormal_fetal_growth/weight/1.26533718
42MP0000428_abnormal_craniofacial_morphol1.25810346
43MP0003890_abnormal_embryonic-extraembry1.25797717
44MP0001879_abnormal_lymphatic_vessel1.23997677
45MP0002088_abnormal_embryonic_growth/wei1.21453506
46MP0004215_abnormal_myocardial_fiber1.19320860
47MP0003300_gastrointestinal_ulcer1.17645381
48MP0003943_abnormal_hepatobiliary_system1.17370595
49MP0009703_decreased_birth_body1.16031532
50MP0004808_abnormal_hematopoietic_stem1.08120605
51MP0001672_abnormal_embryogenesis/_devel1.07732692
52MP0005380_embryogenesis_phenotype1.07732692
53MP0002396_abnormal_hematopoietic_system1.07398762
54MP0000013_abnormal_adipose_tissue1.05124825
55MP0002106_abnormal_muscle_physiology1.03964467
56MP0004264_abnormal_extraembryonic_tissu0.99599657
57MP0010630_abnormal_cardiac_muscle0.99209223
58MP0000778_abnormal_nervous_system0.95775904
59MP0004134_abnormal_chest_morphology0.94874320
60MP0001727_abnormal_embryo_implantation0.94601619
61MP0005451_abnormal_body_composition0.93819535
62MP0002269_muscular_atrophy0.93424170
63MP0004085_abnormal_heartbeat0.92869300
64MP0003115_abnormal_respiratory_system0.92699399
65MP0009697_abnormal_copulation0.92655711
66MP0001849_ear_inflammation0.90977064
67MP0010307_abnormal_tumor_latency0.90049051
68MP0003656_abnormal_erythrocyte_physiolo0.89668898
69MP0002332_abnormal_exercise_endurance0.88444435
70MP0003567_abnormal_fetal_cardiomyocyte0.87733279
71MP0010678_abnormal_skin_adnexa0.86593301
72MP0003632_abnormal_nervous_system0.85228701
73MP0000566_synostosis0.84071471
74MP0008961_abnormal_basal_metabolism0.82326876
75MP0005369_muscle_phenotype0.81180729
76MP0002925_abnormal_cardiovascular_devel0.80895109
77MP0003937_abnormal_limbs/digits/tail_de0.80619300
78MP0001286_abnormal_eye_development0.80593764
79MP0000266_abnormal_heart_morphology0.80507304
80MP0004130_abnormal_muscle_cell0.79501573
81MP0002086_abnormal_extraembryonic_tissu0.78744968
82MP0003279_aneurysm0.75833487
83MP0003763_abnormal_thymus_physiology0.75262631
84MP0002751_abnormal_autonomic_nervous0.73912168
85MP0000003_abnormal_adipose_tissue0.72502355
86MP0001984_abnormal_olfaction0.72051241
87MP0001958_emphysema0.71664639
88MP0002084_abnormal_developmental_patter0.71256822
89MP0000767_abnormal_smooth_muscle0.71089554
90MP0005195_abnormal_posterior_eye0.71072725
91MP0002095_abnormal_skin_pigmentation0.70758264
92MP0005620_abnormal_muscle_contractility0.70754668
93MP0002972_abnormal_cardiac_muscle0.69831006
94MP0002282_abnormal_trachea_morphology0.68923951
95MP0000462_abnormal_digestive_system0.66502602
96MP0001784_abnormal_fluid_regulation0.66257417
97MP0004087_abnormal_muscle_fiber0.66122733
98MP0002166_altered_tumor_susceptibility0.64999558
99MP0003077_abnormal_cell_cycle0.64577286
100MP0004883_abnormal_blood_vessel0.64452555

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)6.56666185
2Male infertility (HP:0003251)5.26348383
3Vertebral arch anomaly (HP:0008438)5.05189043
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.04023410
5Absent/shortened dynein arms (HP:0200106)5.04023410
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77668090
7Abnormal respiratory epithelium morphology (HP:0012253)4.33031109
8Abnormal respiratory motile cilium morphology (HP:0005938)4.33031109
9Abnormal ciliary motility (HP:0012262)4.20992769
10Pulmonary artery stenosis (HP:0004415)4.06440475
11Abnormal respiratory motile cilium physiology (HP:0012261)3.88591040
12Thyroid carcinoma (HP:0002890)3.76275900
13Rhinitis (HP:0012384)3.66540211
14Vitreoretinal degeneration (HP:0000655)3.30521421
15Genetic anticipation (HP:0003743)3.15556372
16Subacute progressive viral hepatitis (HP:0006572)3.15205360
17Poor coordination (HP:0002370)3.14196272
18Viral hepatitis (HP:0006562)3.12165611
19Congenital primary aphakia (HP:0007707)3.09955802
20Gait imbalance (HP:0002141)2.98555462
21Chorioretinal atrophy (HP:0000533)2.98046996
22Long nose (HP:0003189)2.88146033
23Anterior segment dysgenesis (HP:0007700)2.77837777
24Medial flaring of the eyebrow (HP:0010747)2.77180998
25Infertility (HP:0000789)2.74005697
26Abnormality of the musculature of the pelvis (HP:0001469)2.68132369
27Abnormality of the hip-girdle musculature (HP:0001445)2.68132369
28Pelvic girdle muscle weakness (HP:0003749)2.64024678
29Nephrogenic diabetes insipidus (HP:0009806)2.57209624
30Bronchiectasis (HP:0002110)2.55387562
31Hepatocellular carcinoma (HP:0001402)2.46406361
32Curly hair (HP:0002212)2.44772497
33Abnormality of the parathyroid morphology (HP:0011766)2.41772547
34Truncal obesity (HP:0001956)2.31544648
35Occipital encephalocele (HP:0002085)2.31354378
36Exercise-induced myalgia (HP:0003738)2.30688378
37Subaortic stenosis (HP:0001682)2.28771578
38Abnormality of the left ventricular outflow tract (HP:0011103)2.28771578
39Long clavicles (HP:0000890)2.28161329
40Absent frontal sinuses (HP:0002688)2.26520061
41Vaginal atresia (HP:0000148)2.24982518
42Facial diplegia (HP:0001349)2.24601887
43Abnormality of the renal medulla (HP:0100957)2.23175847
44Hepatoblastoma (HP:0002884)2.21367513
45Chronic bronchitis (HP:0004469)2.18073345
46Genital tract atresia (HP:0001827)2.17195228
47Hypoplastic ischia (HP:0003175)2.13916069
48Abnormality of the ischium (HP:0003174)2.10507241
49Large earlobe (HP:0009748)2.04261353
50Recurrent sinusitis (HP:0011108)2.03264300
51Chronic hepatic failure (HP:0100626)2.02343552
52Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.01761198
53Transitional cell carcinoma of the bladder (HP:0006740)1.97895487
54Decreased testicular size (HP:0008734)1.96707084
55Bladder neoplasm (HP:0009725)1.93813957
56Bladder carcinoma (HP:0002862)1.93813957
57Left ventricular hypertrophy (HP:0001712)1.89856474
58Broad foot (HP:0001769)1.89514167
59Male pseudohermaphroditism (HP:0000037)1.89480526
60Cystic hygroma (HP:0000476)1.88893887
61Specific learning disability (HP:0001328)1.87728112
62Rimmed vacuoles (HP:0003805)1.87206792
63Centrally nucleated skeletal muscle fibers (HP:0003687)1.86422681
64Postural instability (HP:0002172)1.86304904
65Neoplasm of the liver (HP:0002896)1.85316629
66Renal dysplasia (HP:0000110)1.83446010
67Hemiplegia (HP:0002301)1.82019016
68Abnormality of the columella (HP:0009929)1.80731506
69Progressive cerebellar ataxia (HP:0002073)1.80533177
70High anterior hairline (HP:0009890)1.80066853
71Nephroblastoma (Wilms tumor) (HP:0002667)1.79595751
72Nasal polyposis (HP:0100582)1.79170775
73Pancreatic fibrosis (HP:0100732)1.79143396
74Abnormality of the fingertips (HP:0001211)1.76008612
75Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.72155212
76Limb-girdle muscle atrophy (HP:0003797)1.71423571
77True hermaphroditism (HP:0010459)1.71014266
78Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.70522477
79Hypoplastic pelvis (HP:0008839)1.69406536
80Colitis (HP:0002583)1.68284401
81Abnormality of the nasal mucosa (HP:0000433)1.67442919
82Periauricular skin pits (HP:0100277)1.66903991
83Preauricular pit (HP:0004467)1.66903991
84Impulsivity (HP:0100710)1.66897609
85Neoplasm of the thyroid gland (HP:0100031)1.65386589
86Abnormality of the epiphyses of the hand (HP:0005924)1.64710432
87Hypoplasia of the iris (HP:0007676)1.64199376
88Embryonal renal neoplasm (HP:0011794)1.61044024
89T lymphocytopenia (HP:0005403)1.60653887
90Short foot (HP:0001773)1.60084740
91Abnormality of the calf musculature (HP:0001430)1.59403719
92Neoplasm of the heart (HP:0100544)1.59122709
93Prominent nose (HP:0000448)1.58363675
94Bronchitis (HP:0012387)1.57619636
95Micropenis (HP:0000054)1.57067387
96Decreased lacrimation (HP:0000633)1.56926596
97Hypercholesterolemia (HP:0003124)1.56621516
98Thyroid-stimulating hormone excess (HP:0002925)1.56486087
99Chronic mucocutaneous candidiasis (HP:0002728)1.56385957
100Recurrent cutaneous fungal infections (HP:0011370)1.56385957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK15.38226806
2CDK63.29435468
3NEK92.76733786
4OBSCN2.57737677
5MAPK152.45309629
6AKT32.30674010
7CSNK1A1L2.26503273
8EPHB12.25650868
9DYRK1B1.86567239
10ERBB21.80666460
11CSNK1G31.78151050
12MAP3K41.67107538
13FER1.60481106
14CSNK1G11.59597290
15PTK2B1.59386553
16BCR1.56308545
17FGFR21.55908958
18NLK1.55787753
19STK101.50928083
20FRK1.38112080
21PAK31.37101273
22SGK21.33584117
23MAP3K101.31001011
24IRAK11.29341658
25YES11.28684735
26CSNK1G21.27996375
27TGFBR21.20228390
28MARK21.13164442
29CDC42BPA1.13043056
30MAP3K71.11136336
31BRSK21.09992467
32MAP3K61.01467501
33CDK31.01197689
34CDK120.99790821
35BLK0.98146591
36PTK60.97258044
37TIE10.96133539
38JAK10.95325854
39TXK0.94238716
40IKBKE0.93001713
41CSK0.91838585
42WNK30.90945578
43PAK40.90645332
44PIK3CG0.89441848
45MAP3K50.87104456
46FGFR30.87080944
47TTN0.86074146
48CHEK20.85905025
49WNK10.85298585
50TNIK0.84569964
51BTK0.83103439
52CAMK40.82578002
53IRAK20.82491007
54MKNK10.79900027
55CHUK0.78891399
56STK38L0.76689410
57SGK2230.76222375
58SGK4940.76222375
59FGFR40.75316236
60TYRO30.74786546
61SGK30.74683385
62TTK0.73395396
63EGFR0.73198843
64AKT20.72158077
65FGR0.71308061
66STK40.70563322
67MST40.69583796
68UHMK10.66599202
69PDGFRB0.63995681
70CDK40.62832745
71PLK40.60144066
72CAMK1G0.59646555
73CCNB10.59219948
74SYK0.58352691
75PAK60.57535281
76MAP2K70.57526878
77IRAK40.56763742
78STK240.56585124
79PINK10.55330813
80DYRK1A0.55111143
81MAPK100.54672886
82MELK0.54631991
83PRKAA10.53871869
84ICK0.52339061
85PDGFRA0.51428151
86CAMK1D0.51383939
87HCK0.49816162
88TEC0.49669586
89MAPK110.48801601
90MAP2K40.47273763
91EIF2AK20.47025531
92GRK70.46431723
93PLK20.46226606
94ATM0.45853938
95SGK10.41601246
96PIM10.40672925
97JAK30.39657271
98RET0.39538887
99CHEK10.39269192
100AURKB0.38851075

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.64479867
2Adherens junction_Homo sapiens_hsa045202.31420023
3Prolactin signaling pathway_Homo sapiens_hsa049172.28760529
4Endometrial cancer_Homo sapiens_hsa052132.16118012
5Thyroid cancer_Homo sapiens_hsa052162.09934884
6Circadian rhythm_Homo sapiens_hsa047102.08151672
7Prostate cancer_Homo sapiens_hsa052152.01940667
8Thyroid hormone signaling pathway_Homo sapiens_hsa049191.94884817
9Non-small cell lung cancer_Homo sapiens_hsa052231.93724787
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75518942
11FoxO signaling pathway_Homo sapiens_hsa040681.69715761
12Chronic myeloid leukemia_Homo sapiens_hsa052201.66873162
13Ovarian steroidogenesis_Homo sapiens_hsa049131.66854775
14Colorectal cancer_Homo sapiens_hsa052101.63109242
15Glioma_Homo sapiens_hsa052141.62440900
16Lysine degradation_Homo sapiens_hsa003101.54932924
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51181082
18MicroRNAs in cancer_Homo sapiens_hsa052061.50437407
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.47814092
20p53 signaling pathway_Homo sapiens_hsa041151.44999246
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44042318
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38552351
23Basal cell carcinoma_Homo sapiens_hsa052171.32392563
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.31818091
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28799990
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26250922
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24375473
28Choline metabolism in cancer_Homo sapiens_hsa052311.21638906
29GnRH signaling pathway_Homo sapiens_hsa049121.20131014
30Cell cycle_Homo sapiens_hsa041101.18622012
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17536079
32mRNA surveillance pathway_Homo sapiens_hsa030151.17524210
33Tight junction_Homo sapiens_hsa045301.17473854
34Small cell lung cancer_Homo sapiens_hsa052221.17326117
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.15636980
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14514968
37Viral carcinogenesis_Homo sapiens_hsa052031.03941492
38Dilated cardiomyopathy_Homo sapiens_hsa054141.02073673
39Pancreatic cancer_Homo sapiens_hsa052121.01972551
40Inositol phosphate metabolism_Homo sapiens_hsa005621.01137522
41ErbB signaling pathway_Homo sapiens_hsa040121.01061097
42Alcoholism_Homo sapiens_hsa050340.97104955
43AMPK signaling pathway_Homo sapiens_hsa041520.94941447
44Focal adhesion_Homo sapiens_hsa045100.94217047
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.94035546
46Hedgehog signaling pathway_Homo sapiens_hsa043400.91479839
47Measles_Homo sapiens_hsa051620.88280350
48mTOR signaling pathway_Homo sapiens_hsa041500.87809111
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87051349
50Systemic lupus erythematosus_Homo sapiens_hsa053220.85489883
51Linoleic acid metabolism_Homo sapiens_hsa005910.84802791
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84720368
53Steroid biosynthesis_Homo sapiens_hsa001000.84701124
54Fanconi anemia pathway_Homo sapiens_hsa034600.84532793
55Wnt signaling pathway_Homo sapiens_hsa043100.84361579
56Acute myeloid leukemia_Homo sapiens_hsa052210.83384822
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82848061
58Hepatitis B_Homo sapiens_hsa051610.81394330
59ABC transporters_Homo sapiens_hsa020100.77008169
60Melanoma_Homo sapiens_hsa052180.75254438
61Hippo signaling pathway_Homo sapiens_hsa043900.73971215
62Rap1 signaling pathway_Homo sapiens_hsa040150.73433144
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72559660
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.72105969
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71576420
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71243395
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71158726
68Renal cell carcinoma_Homo sapiens_hsa052110.68622036
69Melanogenesis_Homo sapiens_hsa049160.68126612
70Pathways in cancer_Homo sapiens_hsa052000.67478602
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66742192
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66676304
73Fatty acid biosynthesis_Homo sapiens_hsa000610.63205256
74Proteoglycans in cancer_Homo sapiens_hsa052050.63077588
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62975900
76Insulin resistance_Homo sapiens_hsa049310.61538103
77Insulin signaling pathway_Homo sapiens_hsa049100.61228257
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61109561
79Primary immunodeficiency_Homo sapiens_hsa053400.60992922
80Butanoate metabolism_Homo sapiens_hsa006500.60782163
81Histidine metabolism_Homo sapiens_hsa003400.60597763
82Bladder cancer_Homo sapiens_hsa052190.60156253
83Oocyte meiosis_Homo sapiens_hsa041140.59658029
84Platelet activation_Homo sapiens_hsa046110.59036680
85Taste transduction_Homo sapiens_hsa047420.58767906
86T cell receptor signaling pathway_Homo sapiens_hsa046600.58256348
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.57806863
88PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56502337
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.54067343
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52918446
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50593142
92Estrogen signaling pathway_Homo sapiens_hsa049150.50014164
93PPAR signaling pathway_Homo sapiens_hsa033200.48075787
94Spliceosome_Homo sapiens_hsa030400.47627498
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47599166
96Propanoate metabolism_Homo sapiens_hsa006400.46858467
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46612863
98HIF-1 signaling pathway_Homo sapiens_hsa040660.43969240
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.42047979
100Renin secretion_Homo sapiens_hsa049240.41657459

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